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Aliases for ADAMTS9 Gene

Aliases for ADAMTS9 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 9 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 9 2 3
  • ADAM-TS 9 3 4
  • ADAM-TS9 3 4
  • ADAMTS-9 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 9 3
  • EC 3.4.24.14 64
  • EC 3.4.24.82 64
  • EC 3.4.24.- 4
  • KIAA1312 4

External Ids for ADAMTS9 Gene

Summaries for ADAMTS9 Gene

Entrez Gene Summary for ADAMTS9 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS9 Gene

ADAMTS9 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 9) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS9 Gene

  • Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

Gene Wiki entry for ADAMTS9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS9 Gene

Genomics for ADAMTS9 Gene

Genomic Location for ADAMTS9 Gene

Start:
64,515,654 bp from pter
End:
64,688,000 bp from pter
Size:
172,347 bases
Orientation:
Minus strand

Genomic View for ADAMTS9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS9 Gene

Regulatory Elements for ADAMTS9 Gene

Proteins for ADAMTS9 Gene

  • Protein details for ADAMTS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N4-ATS9_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 9
    Protein Accession:
    Q9P2N4
    Secondary Accessions:
    • A1L4L0
    • B7ZVX9
    • B9ZVN0
    • Q9NR29

    Protein attributes for ADAMTS9 Gene

    Size:
    1935 amino acids
    Molecular mass:
    216491 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS9 Gene

Proteomics data for ADAMTS9 Gene at MOPED

Selected DME Specific Peptides for ADAMTS9 Gene

Post-translational modifications for ADAMTS9 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn112, Asn135, Asn271, Asn749, Asn840, Asn1213, Asn1267, Asn1788, and Asn1806

Other Protein References for ADAMTS9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADAMTS9 Gene

Gene Families for ADAMTS9 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

UniProtKB/Swiss-Prot:

ATS9_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.:
    • Q9P2N4
  • The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities:
    • Q9P2N4
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9P2N4
  • The GON domain mediates protease-independent function in ER to Golgi transport:
    • Q9P2N4
  • Contains 1 disintegrin domain.:
    • Q9P2N4
  • Contains 1 GON domain.:
    • Q9P2N4
  • Contains 1 peptidase M12B domain.:
    • Q9P2N4
  • Contains 15 TSP type-1 domains.:
    • Q9P2N4
genes like me logo Genes that share domains with ADAMTS9: view

Function for ADAMTS9 Gene

Molecular function for ADAMTS9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site
UniProtKB/Swiss-Prot Function: Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

Enzyme Numbers (IUBMB) for ADAMTS9 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity IDA 12514189
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS9: view
genes like me logo Genes that share phenotypes with ADAMTS9: view

miRNA for ADAMTS9 Gene

miRTarBase miRNAs that target ADAMTS9

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAMTS9 Gene

Localization for ADAMTS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS9 Gene

Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS9 Gene COMPARTMENTS Subcellular localization image for ADAMTS9 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IDA 12514189
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with ADAMTS9: view

Pathways for ADAMTS9 Gene

genes like me logo Genes that share pathways with ADAMTS9: view

Pathways by source for ADAMTS9 Gene

Interacting Proteins for ADAMTS9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418735%0d%0a9606.ENSP00000446121%0d%0a
Selected Interacting proteins: ENSP00000418735 for ADAMTS9 Gene via STRING

Symbol External ID(s) Details
LIMS1

Gene Ontology (GO) - Biological Process for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 12514189
GO:0006516 glycoprotein catabolic process TAS 10936055
GO:0007275 multicellular organismal development TAS 10936055
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ADAMTS9: view

Transcripts for ADAMTS9 Gene

Unigene Clusters for ADAMTS9 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS9 Gene

No ASD Table

Relevant External Links for ADAMTS9 Gene

GeneLoc Exon Structure for
ADAMTS9
ECgene alternative splicing isoforms for
ADAMTS9

Expression for ADAMTS9 Gene

mRNA expression in normal human tissues for ADAMTS9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS9 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS9 Gene Hs.656071

mRNA Expression by UniProt/SwissProt for ADAMTS9 Gene

Q9P2N4-ATS9_HUMAN
Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle
genes like me logo Genes that share expressions with ADAMTS9: view

Orthologs for ADAMTS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS9 36
  • 99.45 (n)
  • 99.64 (a)
ADAMTS9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS9 36
  • 90.23 (n)
  • 92.04 (a)
ADAMTS9 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS9 36
  • 90.67 (n)
  • 92.85 (a)
ADAMTS9 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts9 36
  • 86.41 (n)
  • 89.99 (a)
Adamts9 16
Adamts9 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS9 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS9 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts9 36
  • 86.27 (n)
  • 87.95 (a)
chicken
(Gallus gallus)
Aves ADAMTS9 36
  • 73.7 (n)
  • 76.87 (a)
ADAMTS9 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS9 37
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adamts9 36
  • 66.1 (n)
  • 68.45 (a)
adamts9 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6107 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea gon-1 36
  • 49.88 (n)
  • 41.21 (a)
Species with no ortholog for ADAMTS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAMTS9 Gene

ENSEMBL:
Gene Tree for ADAMTS9 (if available)
TreeFam:
Gene Tree for ADAMTS9 (if available)

Paralogs for ADAMTS9 Gene

Selected SIMAP similar genes for ADAMTS9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS9: view

Variants for ADAMTS9 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs768260 -- 64,537,022(+) AATCA(C/T)GCTTT intron-variant
rs894744 -- 64,550,551(+) CTACA(A/G)TATTT intron-variant
rs920779 -- 64,551,804(+) ggccc(C/T)tgtcc intron-variant
rs959672 -- 64,536,612(+) ACTGA(C/G)CGGCA intron-variant
rs1014640 -- 64,557,939(-) GGGGA(A/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS9 Gene

Variant ID Type Subtype PubMed ID
dgv289n21 CNV Gain 19592680
dgv809n67 CNV Gain 20364138
esv259785 OTHER Complex 20981092
esv259423 OTHER Complex 20981092
esv28694 CNV Gain 19812545
nsv834718 CNV Gain 17160897
esv272472 CNV Insertion 20981092

Relevant External Links for ADAMTS9 Gene

HapMap Linkage Disequilibrium report
ADAMTS9

Disorders for ADAMTS9 Gene

(1) Novoseek inferred disease relationships for ADAMTS9 Gene

Disease -log(P) Hits PubMed IDs
necrosis 9.06 2

Relevant External Links for ADAMTS9

Genetic Association Database (GAD)
ADAMTS9
Human Genome Epidemiology (HuGE) Navigator
ADAMTS9
genes like me logo Genes that share disorders with ADAMTS9: view

No data available for UniProtKB/Swiss-Prot for ADAMTS9 Gene

Publications for ADAMTS9 Gene

  1. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 3 4 23
  2. ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PMID: 10936055) Clark M.E. … Maki R.A. (Genomics 2000) 2 3 4
  3. ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. (PMID: 19052845) Yaykasli K.O. … Ninomiya Y. (Mol. Cell. Biochem. 2009) 3 23
  4. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. (PMID: 19963134) Zhang C. … Wan J. (Cancer Genet. Cytogenet. 2010) 3 23
  5. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. (PMID: 20093484) Koo B.H. … Apte S.S. (Am. J. Pathol. 2010) 3 23

Products for ADAMTS9 Gene

Sources for ADAMTS9 Gene

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