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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS9 Gene

protein-coding   GIFtS: 55
GCID: GC03M064501

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 91 2     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 92
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 91 2
     EC 3.4.24.-3
ADAM-TS92 3     KIAA13123
ADAMTS-92 3     EC 3.4.24.148
ADAM-TS 92 3     EC 3.4.24.828

External Ids:    HGNC: 132021   Entrez Gene: 569992   Ensembl: ENSG000001636387   OMIM: 6054215   UniProtKB: Q9P2N43   

Export aliases for ADAMTS9 gene to outside databases

Previous GC identifers: GC03M063400 GC03M063939 GC03M064356 GC03M064458 GC03M064476


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS9 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of
the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during
development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known
to be lost in hereditary renal tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS9 Gene: 
ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif, 9) is a protein-coding gene. Diseases associated with ADAMTS9 include chondrosarcoma, and nasopharyngitis. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
Function: Cleaves the large aggregating proteoglycans, aggrecan and versican

Gene Wiki entry for ADAMTS9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS9 gene promoter:
         c-Fos   AP-1   p53   NRSF form 1   STAT5A   NRSF form 2   AREB6   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.1

ADAMTS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M064501:  view genomic region     (about GC identifiers)

Start:
64,501,330 bp from pter      End:
64,673,676 bp from pter
Size:
172,347 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor  
Size: 1935 amino acids; 216491 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: A1L4L0 B9ZVN0 Q9NR29
Alternative splicing: 3 isoforms:  Q9P2N4-3   Q9P2N4-1   Q9P2N4-2   (May result from the retention of an intron in the cDNA leading to a prematurate stop codon)

Explore the universe of human proteins at neXtProt for ADAMTS9: NX_Q9P2N4

Explore proteomics data for ADAMTS9 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2N4

  • 3 DME Specific Peptides for ADAMTS9 (Q9P2N4)
     VCGGDNS  DKCGVCGG  AHELGHVF 

    ADAMTS9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS9 Protein Expression
    REFSEQ proteins: NP_891550.1  
    ENSEMBL proteins: 
     ENSP00000295903   ENSP00000418735   ENSP00000417521   ENSP00000419217  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IDA12514189
    GO:0005615extracellular space IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    ADAMTS9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS9 
    ADAMTS family

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry Q9P2N4

    ProtoNet protein and cluster: Q9P2N4

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The ancillary domains, including the TSRs domain, are required for specific extracellular localization and
    for its versicanase and aggrecanase activities
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 GON domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 15 TSP type-1 domains


    ADAMTS9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS9_HUMAN, Q9P2N4
    Function: Cleaves the large aggregating proteoglycans, aggrecan and versican
    Catalytic activity: Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity IDA12514189
    GO:0008270zinc ion binding IEA--
         
    ADAMTS9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTS9:
     Decreased cilium length after  

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adamts9):
     embryogenesis  integument  limbs/digits/tail  mortality/aging  nervous system 
     pigmentation 

    ADAMTS9 for phenotypes           About GeneDecksing

    Animal Models:
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    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS9 (see all 53):
    hsa-miR-548j hsa-miR-4254 hsa-miR-607 hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-877* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS9 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS9

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA12514189
    GO:0006516glycoprotein catabolic process TAS10936055
    GO:0007275multicellular organismal development TAS10936055
    GO:0045636positive regulation of melanocyte differentiation IEA--
    GO:0048070regulation of developmental pigmentation ----

    ADAMTS9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS9 (ATS9)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS9 / ATS9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS9 gene: 
    NM_182920.1  

    Unigene Cluster for ADAMTS9:

    ADAM metallopeptidase with thrombospondin type 1 motif, 9
    Hs.656071  [show with all ESTs]
    Unigene Representative Sequence: NM_182920
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477180 ENST00000295903 ENST00000498707(uc003dmg.3 uc011bfo.2)
    ENST00000467257 ENST00000481060(uc011bfp.1) ENST00000482490(uc003dmh.1)
    ENST00000475557(uc003dmk.1) ENST00000459780 ENST00000467119 ENST00000494004

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    SwitchGear 3'UTR luciferase reporter plasmidADAMTS9 3' UTR sequence
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    Additional mRNA sequence: 

    AB037733.1 AF488803.1 AK124945.1 AK300357.1 AK303343.1 AK310571.1 BC026271.2 BC036770.1 
    BC130578.1 BC171764.1 

    6 DOTS entries:

    DT.100814942  DT.91904315  DT.100684795  DT.40207529  DT.95261455  DT.75158360 

    24/117 AceView cDNA sequences (see all 117):

    CB043880 AW020835 NM_020249 AI890599 AW170735 AI499485 AI632702 BM682012 
    CB215591 AI479925 BX508930 CA425143 AA382928 AI333066 AI280794 BF724218 
    N91696 BM729081 AA705567 NM_182920 BC036770 AW015503 CD686374 NM_182921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS9 expression in normal human tissues (normalized intensities)      ADAMTS9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGACACTT
    ADAMTS9 Expression
    About this image


    ADAMTS9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
             cd31+ cells   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Juxtaglomerular Cells Afferent Arteriole
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             cd31+ cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Paraxial Mesoderm Cells Head Mesenchyme
             skeleton/pectoral girdle and thoracic body wall/sternum   

    See ADAMTS9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS9

    SOURCE GeneReport for Unigene cluster: Hs.656071

    UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
    Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest
    expression in heart, placenta and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS9 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts91 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 86.41(n)1
    89.99(a)1
      6 (41.41 cM)5
    1014011  NM_175314.31  NP_780523.21 
     927726995 
    chicken
    (Gallus gallus)
    Aves ADAMTS91 ADAM metallopeptidase with thrombospondin type 1 motif, more 73.7(n)
    77.08(a)
      416080  XM_414417.2  XP_414417.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    74(a)
    73(a)
    1 ↔ many
    1 ↔ many
    GL343210.1(1188949-1299105)
    GL343210.1(1329539-1368376)
    zebrafish
    (Danio rerio)
    Actinopterygii adamts91 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.69(n)
    69.26(a)
      100333407  XM_002663761.2  XP_002663807.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61073 metallocarboxypeptidase D 34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gon-11 Protein GON-1 49.68(n)
    41.25(a)
      177850  NM_069391.2  NP_501792.2 


    ENSEMBL Gene Tree for ADAMTS9 (if available)
    TreeFam Gene Tree for ADAMTS9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS9 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS52  ADAMTS152  ADAMTS42  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    13 SIMAP similar genes for ADAMTS9 using alignment to 4 protein entries:     ATS9_HUMAN (see all proteins):
    ADAMTS4    ADAMTS1    ADAMTS20    ADAMTSL1    DKFZp686E01144    ADAMTS8
    ADAMTS15    ADAMTS13    ADAMTS6    ADAMTS16    ADAMTS18    C9orf8
    DKFZp434K1772

    ADAMTS9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4189 SNPs in ADAMTS9 are shown (see all 4189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0515924
    ----see VAR_0515922 S T mis40--------
    VAR_0470814
    ----see VAR_0470812 S P mis40--------
    rs1168316741,2
    F--64501119(+) GAGGGG/TTAAGT 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs786068551,2
    C,F--64501131(+) CCCAGT/CTTCCA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs599792301,2
    F--64501146(+) AACCAC/TTTTAA 1 -- ds50010--------
    rs738344801,2
    C,F--64501175(+) AGACAG/CATCTT 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs1853695481,2
    --64501191(+) CAAGCC/GCCATC 1 -- ds50010--------
    rs746237311,2
    C,F--64501211(+) CTCTAG/CAATGG 1 -- ds50012Minor allele frequency- C:0.04CSA WA 119
    rs1386885881,2
    --64501334(+) GTTTGA/GGTGTG 1 -- ut310--------
    rs802915671,2
    C--64501410(+) TACTGA/CATATA 1 -- ut312Minor allele frequency- C:0.04CSA WA 119

    HapMap Linkage Disequilibrium report for ADAMTS9 (64501330 - 64673676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADAMTS9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272472CNV Insertion20981092
    nsv834718CNV Gain17160897
    dgv809n67CNV Gain20364138
    dgv289n21CNV Gain19592680
    esv28694CNV Gain19812545
    esv259423OTHER Complex20981092
    esv259785OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605421    OMIM disorders: --

    13 diseases for ADAMTS9:    About MalaCards
    chondrosarcoma    nasopharyngitis    esophageal squamous cell carcinoma    diabetes mellitus
    esophagitis    obesity    squamous cell carcinoma    pancreatic cancer
    retinitis    pancreatitis    prostate cancer    prostatitis
    endotheliitis


    ADAMTS9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ADAMTS9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.06 2 15880812 (2)

    Genetic Association Database (GAD): ADAMTS9
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS9 (38 documents)

    Export disorders for ADAMTS9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS9 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with ADAMTS9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PubMed id 10936055)1, 2, 3 Clark M.E....Maki R.A. (2000)
    2. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PubMed id 12514189)1, 2, 9 Somerville R.P.... Apte S.S. (2003)
    3. Genome-wide association analysis of age-at-onset in Al zheimer's disease. (PubMed id 22005931)1, 4 Kamboh M.I....Lopez O.L. (2012)
    4. Gene variants in the novel type 2 diabetes loci CDC12 3/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancre atic beta-cell function. (PubMed id 19833888)1, 4 Simonis-Bik A.M....'t Hart L.M. (2010)
    5. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and H HEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (2010)
    6. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1, 4 Wen J....Hu R. (2010)
    7. Genetic susceptibility to type 2 diabetes is associat ed with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (2010)
    8. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (2010)
    9. Lack of significant effects of the type 2 diabetes su sceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. (PubMed id 19670153)1, 4 Schleinitz D....Stumvoll M. (2010)
    10. Impact of single nucleotide polymorphisms and of clin ical risk factors on newa89onset diabetes mellitus in HIVa89infected individuals. (PubMed id 20879858)1, 4 Rotger M....Tarr P.E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56999 HGNC: 13202 AceView: ADAMTS9 Ensembl:ENSG00000163638 euGenes: HUgn56999
    ECgene: ADAMTS9 H-InvDB: ADAMTS9

    (According to HUGE)
    About This Section
    HUGE: KIAA1312

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS9 gene:
    Search GeneIP for patents involving ADAMTS9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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