Aliases for ADAMTS9 Gene
External Ids for ADAMTS9 Gene
Previous GeneCards Identifiers for ADAMTS9 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS9 Gene
ADAMTS9 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 9) is a Protein Coding gene. Diseases associated with ADAMTS9 include macular degeneration, age-related, 1. Among its related pathways are Degradation of the extracellular matrix and Transport to the Golgi and subsequent modification. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS16.
UniProtKB/Swiss-Prot for ADAMTS9 Gene
Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.