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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS9 Gene

protein-coding   GIFtS: 54
GCID: GC03M064476

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 14 diseases affiliated with
ADAMTS9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS9    

Aliases
for ADAMTS9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 91 2     ADAM-TS 92 3
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 91 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 92
KIAA13121 3     EC 3.4.24.-3
ADAM-TS92 3     EC 3.4.24.148
ADAMTS-92 3     EC 3.4.24.828

External Ids:    HGNC: 132021   Entrez Gene: 569992   Ensembl: ENSG000001636387   OMIM: 6054215   UniProtKB: Q9P2N43   

Export aliases for ADAMTS9 gene to outside databases

Previous GC identifers: GC03M063400 GC03M063939 GC03M064356 GC03M064458


Summaries
for ADAMTS9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS9:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the
ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development,
and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in
hereditary renal tumors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
Function: Cleaves the large aggregating proteoglycans, aggrecan and versican

Gene Wiki entry for ADAMTS9


Genomic Views
for ADAMTS9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS9 gene promoter:
         c-Fos   AP-1   p53   NRSF form 1   STAT5A   NRSF form 2   AREB6   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.1

ADAMTS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M064476:  view genomic region     (about GC identifiers)

Start:
 64,501,330 bp from pter      End:
 64,673,676 bp from pter
Size:
 172,347 bases      Orientation:
 minus strand

Proteins
for ADAMTS9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor  
Size: 1935 amino acids; 216491 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: A1L4L0 B9ZVN0 Q9NR29
Alternative splicing: 3 isoforms:  Q9P2N4-3   Q9P2N4-1   Q9P2N4-2   (May result from the retention of an intron in the cDNA leading to a prematurate stop codon)

Explore the universe of human proteins at neXtProt for ADAMTS9: NX_Q9P2N4

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2N4

    • 3 DME Specific Peptides for ADAMTS9 (Q9P2N4)
     VCGGDNS  DKCGVCGG  AHELGHVF 

    ADAMTS9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_891550.1  
    ENSEMBL proteins: 
     ENSP00000295903   ENSP00000418735   ENSP00000417521   ENSP00000419217  

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    Uscn Proteins for ADAMTS9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IDA12514189
    GO:0005615extracellular space IEA--
    GO:0031012colocalizes with extracellular matrix ISS--


    ADAMTS9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADAMTS9

    Protein Domains /
    Families
    for ADAMTS9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS9 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry Q9P2N4

    ProtoNet protein and cluster: Q9P2N4

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for
    its versicanase and aggrecanase activities
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 GON domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 15 TSP type-1 domains


    Function
    for ADAMTS9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
    Function: Cleaves the large aggregating proteoglycans, aggrecan and versican
    Catalytic activity: Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822

    miRNA
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    hsa-mir-29a (MIRT005668)

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    hsa-miR-548j hsa-miR-4254 hsa-miR-607 hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-877* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS9 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: ADAMTS9
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    Gene Editing
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    Search LifeMap BioReagents cell lines for ADAMTS9

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity IDA12514189
    GO:0008270zinc ion binding IEA--


    ADAMTS9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADAMTS9:
     Decreased cilium length after  

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adamts9):
     embryogenesis  integument  limbs/digits/tail  mortality/aging  nervous system 
     pigmentation 

    ADAMTS9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAMTS9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS9

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA12514189
    GO:0006516glycoprotein catabolic process TAS10936055
    GO:0007275multicellular organismal development TAS10936055
    GO:0045636positive regulation of melanocyte differentiation IEA--
    GO:0048070regulation of developmental pigmentation ----


    ADAMTS9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS9
    Search CenterWatch for drugs/clinical trials and news about ADAMTS9 / ATS9 

    Transcripts
    for ADAMTS9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS9 gene: 
    NM_182920.1  

    Unigene Cluster for ADAMTS9:

    ADAM metallopeptidase with thrombospondin type 1 motif, 9
    Hs.656071  [show with all ESTs]
    Unigene Representative Sequence: NM_182920
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477180 ENST00000295903 ENST00000498707(uc003dmg.3 uc011bfo.2)
    ENST00000467257 ENST00000481060(uc011bfp.1) ENST00000482490(uc003dmh.1)
    ENST00000475557(uc003dmk.1) ENST00000459780 ENST00000467119 ENST00000494004


    miRNA
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    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS9 (see all 53):
    hsa-miR-548j hsa-miR-4254 hsa-miR-607 hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-877* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS9 (see all 7)
    OriGene shRNA RFP: ADAMTS9
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADAMTS9 (NM_182920)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS9

    Additional cDNA sequence: 

    AB037733.1 AF488803.1 AK124945.1 AK300357.1 AK303343.1 AK310571.1 BC026271.2 BC036770.1 
    BC130578.1 BC171764.1 

    6 DOTS entries:

    DT.100814942  DT.91904315  DT.100684795  DT.40207529  DT.95261455  DT.75158360 

    24/117 AceView cDNA sequences (see all 117):

    BM729081 AI479925 AI217325 BE465831 AW338283 CD514469 BX508930 BF476788 
    AB037733 AI333066 AI078611 BC036770 CR619556 NM_182921 CD686374 NM_182920 
    BM993252 AW020835 CA425143 NM_020249 AI280794 BF724218 CA419190 AI499485 

    GeneLoc Exon Structure


    Expression
    for ADAMTS9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGACACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTS9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Posterior foregut-like cells (A scalable, suspensi...)
    DKK1-induced cells (Derivation of cardio...)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)
    Mesoderm-like cells (Derivation of cardio...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

    See ADAMTS9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS9

    SOURCE GeneReport for Unigene cluster: Hs.656071

    UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4
    Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest
    expression in heart, placenta and skeletal muscle

        SABiosciences Custom PCR Arrays for ADAMTS9
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    In Situ
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    Orthologs
    for ADAMTS9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS9 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS91 ADAM metallopeptidase with thrombospondin type 1 motif, more 73.7(n)
    77.08(a)    		   416080  XM_414417.2  XP_414417.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 74(a)
    73(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343210.1(1188949-1299105)
    GL343210.1(1329539-1368376)
    zebrafish
    (Danio rerio)    		 Actinopterygii adamts91 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.69(n)
    69.26(a)    		   100333407  XM_002663761.2  XP_002663807.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG61073 metallocarboxypeptidase D 34(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea gon-11 Protein GON-1 49.68(n)
    41.25(a)    		   177850  NM_069391.2  NP_501792.2 


    ENSEMBL Gene Tree for ADAMTS9 (if available)
    TreeFam Gene Tree for ADAMTS9 (if available) 

    Paralogs
    for ADAMTS9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS9 gene
    ADAMTS72  ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS62  ADAMTS192  ADAMTS122  ADAMTS142  
    ADAMTS22  ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS152  ADAMTS162  ADAMTS82  ADAMTS32  
    ADAMTS102  
    13 SIMAP similar genes for ADAMTS9 using alignment to 4 protein entries:     ATS9_HUMAN (see all proteins):
    ADAMTS4    ADAMTS20    ADAMTS1    ADAMTSL1    DKFZp686E01144    ADAMTS8
    ADAMTS15    ADAMTS13    ADAMTS6    ADAMTS16    ADAMTS18    C9orf8
    DKFZp434K1772

    ADAMTS9 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3595 NCBI SNPs in ADAMTS9 are shown (see all 3595)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1168316741,2
    		F,--64501119(+) GAGGGG/TTAAGT 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs786068551,2
    		F,--64501131(+) CCCAGT/CTTCCA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs599792301,2
    		--64501146(+) AACCAC/TTTTAA 1 -- ds50010--------
    rs738344801,2
    		C,--64501175(+) AGACAG/CATCTT 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs1853695481,2
    		--64501191(+) CAAGCC/GCCATC 1 -- ds50010--------
    rs746237311,2
    		--64501211(+) CTCTAG/CAATGG 1 -- ds50012Minor allele frequency- C:0.04CSA WA 119
    rs1386885881,2
    		--64501334(+) GTTTGA/GGTGTG 1 -- ut310--------
    rs802915671,2
    		C,--64501410(+) TACTGA/CATATA 1 -- ut312Minor allele frequency- C:0.04CSA WA 119
    rs1169586221,2
    		--64501580(+) AGACCA/GTGGCT 1 -- ut311Minor allele frequency- G:0.01EA 120
    rs1145421341,2
    		C,F,--64501618(+) ACAAAA/GAAGTG 1 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for ADAMTS9 (64501330 - 64673676 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAMTS9
         2 CNVs: 79784 63484

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    Disorders / Diseases
    for ADAMTS9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS9 for disorders           About GeneDecksing

    OMIM gene information: 605421    OMIM disorders: --

    14 diseases for ADAMTS9:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    diabetes mellitus    chondrosarcoma
    hermaphroditism    esophagitis    nasopharyngitis    pancreatic cancer
    prostate cancer    pancreatitis    obesity    carcinoma
    retinitis    prostatitis

    1 Novoseek disease relationship for ADAMTS9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.06 2 15880812 (2)

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS9 (38 documents)

    Export disorders for ADAMTS9 gene to outside databases

    Publications
    for ADAMTS9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS9 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with ADAMTS9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PubMed id 10936055)1, 2, 3 Clark M.E....Maki R.A. (2000)
    2. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PubMed id 12514189)1, 2, 9 Somerville R.P.... Apte S.S. (2003)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    4. High-resolution melting analysis of ADAMTS9 methylati on levels in gastric, colorectal, and pancreatic cancers. (PubMed id 19963134)1, 9 Zhang C....Wan J. (2010)
    5. ADAMTS9 is a cell-autonomously acting, anti-angiogeni c metalloprotease expressed by microvascular endothelial cells. (PubMed id 20093484)1, 9 Koo B.H....Apte S.S. (2010)
    6. ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. (PubMed id 19052845)1, 9 Yaykasli K.O....Ninomiya Y. (2009)
    7. Genome-wide association analysis of age-at-onset in Al zheimer's disease. (PubMed id 22005931)1 Kamboh M.I....Lopez O.L. (2012)
    8. Identification of a novel ADAMTS9/GON-1 function for p rotein transport from the ER to the Golgi. (PubMed id 22419820)1 Yoshina S....Mitani S. (2012)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    10. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchyma l stem cells. (PubMed id 22562232)1 Boeuf S....Richter W. (2012)

    External Searches for ADAMTS9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ADAMTS9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56999 HGNC: 13202 AceView: ADAMTS9 Ensembl:ENSG00000163638 euGenes: HUgn56999
    ECgene: ADAMTS9 H-InvDB: ADAMTS9

    Other Databases showing ADAMTS9 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1312

    Specialized Databases showing ADAMTS9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAMTS9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS9 gene:
    Search GeneIP for patents involving ADAMTS9

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