ADAMTS9 Gene
protein-coding GIFtS : 56
GC03M064476
ADAM metallopeptidase with thrombospondin type 1 motif, 9 (Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for ADAMTS9
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ADAM-TS9 3 ADAMTS-9 3 EC 3.4.24.- 3 FLJ42955 2 KIAA1312 1 , 2 , 3
Descriptions ADAM metallopeptidase with thrombospondin type 1 motif, 9 2 ADAM-TS 9 3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 1 , 2
Search outside databases for aliases for ADAMTS9 genePrevious GC identifers: GC03M063400 GC03M063939 GC03M064356 GC03M064458
Summaries for ADAMTS9 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ADAMTS9 : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondinmotifs) protein family. Members of the family share several distinct protein modules, including apropeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondintype 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in thecleavage of proteoglycans, the control of organ shape during development, and the inhibition ofangiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost inhereditary renal tumors. [provided by RefSeq] UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 Function : Cleaves the large aggregating proteoglycans, aggrecan and versican
Gene Wiki entry for ADAMTS9
Genomic Location for ADAMTS9
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ADAMTS9 gene Entrez Gene cytogenetic band: 3p14.3-p14.2 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p14.1 ADAMTS9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M064476:
(about GC identifiers )
Start:
64,476,370 bp from pter
End:
64,648,405 bp from pter
Size:
172,036 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for ADAMTS9
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 (See
protein sequence )Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor Size : 1935 amino acids; 216491 Da
Cofactor : Binds 1 zinc ion per subunit (By similarity)
Subcellular location : Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions : A1L4L0 Q9NR29Alternative splicing : 3 isoforms : Q9P2N4-3 Q9P2N4-1 Q9P2N4-2
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
REFSEQ proteins: NP_891550.1 ENSEMBL proteins: ENSP00000295903 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ADAMTS9: Assays for ADAMTS9:
Protein
Domains/ Families for ADAMTS9(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9P2N4 ProtoNet protein and cluster: Q9P2N4
5 Blocks protein families : IPB000884 Thrombospondin IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB008085 Thrombospondin type 1 repeat signature IPB010294 ADAM-TS Spacer 1 UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 Domain : The spacer domain and the TSP type-1 domains are important for a tight interaction with theextracellular matrix (By similarity) Domain : The ancillary domains, including the TSRs domain, are required for specific extracellularlocalization and for its versicanase and aggrecanase activities Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon theactivation-peptide release activates the enzyme Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 GON domainSimilarity : Contains 1 peptidase M12B domainSimilarity : Contains 15 TSP type-1 domains
Gene Function for ADAMTS9
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_020249 Applied Biosystems Silencer ® siRNAs for ADAMTS9 Sigma-Aldrich siRNA and siRNA Panels for ADAMTS9 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS9 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_182920                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_182920                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_020249  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_182920 UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 Function : Cleaves the large aggregating proteoglycans, aggrecan and versicanCatalytic activity : Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu--Ala-1429 site Enzyme Number (IUBMB): EC 3.4.24.-
4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for ADAMTS9
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS9 --3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for ADAMTS9 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for ADAMTS9
Browse Tocris compounds for ADAMTS9
Transcripts for ADAMTS9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_020249 Sigma-Aldrich siRNA and siRNA Panels for ADAMTS9 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS9 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_182920
REFSEQ mRNAs for ADAMTS9 gene: NM_182920.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_182920
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182920                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_182920                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_020249  
Additional cDNA sequence: AB037733.1 AF488803.1 AK124945.1 AK300357.1 AK303343.1 AK310571.1 BC026271.2 BC036770.1 BC130578.1 BC171764.1 CR619556.1
6 DOTS entries : DT.100814942 DT.91904315 DT.100684795 DT.40207529 DT.95261455 DT.75158360
24/117 AceView cDNA sequences (see all 117
):NM_182921 NM_020249 BE465831 BM729081 N91696 AI217325 AI890599 BM993252 AA705567 NM_182920 BF476788 AB037733 BC036770 AI632702 CD686374 CA425143 AA382928 CB043880 CA419190 CB215591 AI479925 AW015503 AW338283 AI078611
highest scoring ESTs for ADAMTS9 :AF488803 BC036770 BM923892 AA205581 AA382928 AB037733 AF261918 AK124945 AL597900 AL698299
Unigene Cluster for ADAMTS9: ADAM metallopeptidase with thrombospondin type 1 motif, 9 Hs.656071 [show with all ESTs ] Unigene Representative Sequence: NM_182920 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000295903
Expression for ADAMTS9
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ADAMTS9 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS9 1 / 2 / 3
8 probe-sets matching ADAMTS9 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAAGACACTTSOURCE GeneReport for Unigene cluster: Hs.656071 UniProtKB/Swiss-Prot: ATS9_HUMAN, Q9P2N4 Tissue specificity : Highly expressed in all fetal tissues. Expressed in a number of adult tissueswith highest expression in heart, placenta and skeletal muscle
Orthologs for ADAMTS9
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ADAMTS9 gene from 5/9 species (see all 9
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
ADAMTS91
--
ADAM metallopeptidase with thrombospondin type 1 motif, more
90.65(n) 92.85(a)
606847 XM_843300.1 XP_848393.1
chimpanzee (Pan troglodytes)
ADAMTS91
--
ADAM metallopeptidase with thrombospondin type 1 motif, more
99.45(n) 99.64(a)
473333 XM_528704.2 XP_528704.2
cow (Bos taurus)
ADAMTS91
--
ADAM metallopeptidase with thrombospondin type 1 motif, more
90.21(n) 92.06(a)
537051 XM_617206.3 XP_617206.3
rat (Rattus norvegicus)
Adamts91
--
a disintegrin-like and metalloprotease (reprolysin more
86.42(n) 88.24(a)
312566 XM_232202.4 XP_232202.4
mouse (Mus musculus)
Adamts95
6
a disintegrin-like and metallopeptidase (reprolysin more
--
CN703716
About this table Species with no ortholog for ADAMTS9 ENSEMBL Gene Tree for ADAMTS9 Paralogs for ADAMTS9 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ADAMTS9 gene ADAMTS15 2 ADAMTS20 2
SNPs/Variants for ADAMTS9 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ADAMTS9 (up to first 250kb)
Disorders & Mutations for ADAMTS9
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605421 1 Novoseek disease relationship for ADAMTS9 gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis
12.68
2
15880812 (2)
About this table Human Genome Epidemiology Navigator: ADAMTS9 (9 documents)
Medical News for ADAMTS9 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ADAMTS9 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/26 PubMed articles for ADAMTS9 gene (see all 26
): ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PubMed id 10936055) 2, 3, 4 Clark M.E....Maki R.A. (2000) Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PubMed id 12514189) 1, 3, 4 Somerville R.P.... Apte S.S. (2003) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198) 3, 4 Nagase T....Ohara O. (2000) Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. (PubMed id 19324937) 3 Brito E.C....Franks P.W. (2009) Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PubMed id 19139842) 3 Lin X....Mooser V. (2009) Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. (PubMed id 19247373) 3 Sanghera D.K....Ralhan S. (2009) Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. (PubMed id 18714373) 3 Staiger H....Haring H.U. (2008) Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. (PubMed id 18591388) 3 Lango H....Weedon M.N. (2008) Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. (PubMed id 18449890) 3 Lung H.L....Lung M.L. (2008) Genotype score in addition to common risk factors for prediction of type 2 diabetes. (PubMed id 19020323) 3 Meigs J.B....Cupples L.A. (2008)
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Genome Databases showing ADAMTS9
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ADAMTS9
(According to HUGE )
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Specialized Databases showing ADAMTS9 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ADAMTS9 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ADAMTS9:
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