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Aliases for ADAMTS8 Gene

Aliases for ADAMTS8 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 8 2 3
  • ADAM-TS8 3 4
  • ADAMTS-8 3 4
  • METH-2 3 4
  • METH-8 3 4
  • METH2 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8 3
  • EC 61
  • EC 61
  • EC 3.4.24.- 4
  • ADAM-TS 8 4
  • EC 3.4.24 61

External Ids for ADAMTS8 Gene

Previous GeneCards Identifiers for ADAMTS8 Gene

  • GC11M132275
  • GC11M131787
  • GC11M129812
  • GC11M129780
  • GC11M126229

Summaries for ADAMTS8 Gene

Entrez Gene Summary for ADAMTS8 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS8 Gene

ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS1.

UniProtKB/Swiss-Prot for ADAMTS8 Gene

  • Has anti-angiogenic properties.

Gene Wiki entry for ADAMTS8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS8 Gene

Genomics for ADAMTS8 Gene

Regulatory Elements for ADAMTS8 Gene

Enhancers for ADAMTS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G130896 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -468.8 -468796 3.2 PKNOX1 BMI1 YY1 GATA2 ETV6 FOS RELB CREM IKZF2 ZNF680 SNX19 ADAMTS8 LOC103611081 LOC100507431 ADAMTS15 GC11P130904 GC11M130881
GH11G130165 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +261.9 261932 3.8 TBP ELF3 PKNOX1 ARID4B RAD21 RARA FOS MIXL1 REST TBX21 ST14 ADAMTS8 LOC103611081 LOC100507431 PRDM10 GC11P130253
GH11G130827 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -401.3 -401320 6.1 CTCF KLF1 SIN3A BMI1 RAD21 RELA FOSL1 ZFHX2 SMC3 FOS LOC103611081 SNX19 ADAMTS8 LOC100507431 GC11P130847 GC11P130806
GH11G130633 1.5 FANTOM5 Ensembl ENCODE 10.3 -206.6 -206589 4.7 PKNOX1 FOXA2 SIN3A FEZF1 BRCA1 FOS ZNF263 JUNB TSHZ1 SMARCA4 C11orf44 ADAMTS8 GC11M130638 GC11M130509
GH11G130388 1.3 Ensembl ENCODE dbSUPER 11 +39.3 39265 2.7 CTCF FOXA2 RAD21 RARA ZNF7 TEAD3 SMC3 FOS GATAD2A MTA2 ADAMTS8 ADAMTS15 LOC646383 GC11P130399 GC11P130370 PIR51323
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAMTS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS8 Gene

130,404,923 bp from pter
130,428,993 bp from pter
24,071 bases
Minus strand

Genomic View for ADAMTS8 Gene

Genes around ADAMTS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS8 Gene

Proteins for ADAMTS8 Gene

  • Protein details for ADAMTS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 8
    Protein Accession:
    Secondary Accessions:
    • Q9NZS0

    Protein attributes for ADAMTS8 Gene

    889 amino acids
    Molecular mass:
    96460 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS8 Gene

Selected DME Specific Peptides for ADAMTS8 Gene


Post-translational modifications for ADAMTS8 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=344344, posLast=400400, posLast=465465, posLast=490490, and posLast=599599
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ADAMTS8
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADAMTS8

Domains & Families for ADAMTS8 Gene

Gene Families for ADAMTS8 Gene

Suggested Antigen Peptide Sequences for ADAMTS8 Gene

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
genes like me logo Genes that share domains with ADAMTS8: view

Function for ADAMTS8 Gene

Molecular function for ADAMTS8 Gene

UniProtKB/Swiss-Prot Function:
Has anti-angiogenic properties.

Enzyme Numbers (IUBMB) for ADAMTS8 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 10438512
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10438512
genes like me logo Genes that share ontologies with ADAMTS8: view
genes like me logo Genes that share phenotypes with ADAMTS8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS8

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS8 Gene

Localization for ADAMTS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS8 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS8 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 colocalizes_with extracellular matrix ISS,IEA 22261194
genes like me logo Genes that share ontologies with ADAMTS8: view

Pathways & Interactions for ADAMTS8 Gene

genes like me logo Genes that share pathways with ADAMTS8: view

Gene Ontology (GO) - Biological Process for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008285 negative regulation of cell proliferation TAS 10438512
GO:0035435 phosphate ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ADAMTS8: view

No data available for SIGNOR curated interactions for ADAMTS8 Gene

Drugs & Compounds for ADAMTS8 Gene

No Compound Related Data Available

Transcripts for ADAMTS8 Gene

mRNA/cDNA for ADAMTS8 Gene

Unigene Clusters for ADAMTS8 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - - - - - - - -
SP3: -

Relevant External Links for ADAMTS8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS8 Gene

This gene is overexpressed in Lung (x8.5) and Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for ADAMTS8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS8 Gene

Protein tissue co-expression partners for ADAMTS8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS8 Gene:


SOURCE GeneReport for Unigene cluster for ADAMTS8 Gene:


mRNA Expression by UniProt/SwissProt for ADAMTS8 Gene:

Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney.

Evidence on tissue expression from TISSUES for ADAMTS8 Gene

  • Lung(4.5)
genes like me logo Genes that share expression patterns with ADAMTS8: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS8 Gene

Orthologs for ADAMTS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS8 34 35
  • 99.1 (n)
(Canis familiaris)
Mammalia ADAMTS8 34 35
  • 88.15 (n)
(Mus musculus)
Mammalia Adamts8 34 16 35
  • 83.72 (n)
(Rattus norvegicus)
Mammalia Adamts8 34
  • 82.94 (n)
(Bos Taurus)
Mammalia ADAMTS8 34 35
  • 82.92 (n)
(Ornithorhynchus anatinus)
Mammalia ADAMTS8 35
  • 81 (a)
(Monodelphis domestica)
Mammalia ADAMTS8 35
  • 79 (a)
(Gallus gallus)
Aves ADAMTS8 34 35
  • 76.94 (n)
(Anolis carolinensis)
Reptilia ADAMTS8 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts8 34
  • 58.75 (n)
(Danio rerio)
Actinopterygii adamts8a 34 35
  • 61.77 (n)
adamts15b 35
  • 50 (a)
Species where no ortholog for ADAMTS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS8 Gene

Gene Tree for ADAMTS8 (if available)
Gene Tree for ADAMTS8 (if available)

Paralogs for ADAMTS8 Gene

(12) SIMAP similar genes for ADAMTS8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS8: view

Variants for ADAMTS8 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs199760382 Uncertain significance 130,406,119(+) TCATT(G/T)TAGCC intron-variant, reference, stop-gained
rs1000073917 -- 130,425,887(+) TGAGC(C/T)ACCGT intron-variant
rs1000090539 -- 130,420,850(+) ATCAC(A/G)TCATT intron-variant
rs1000135900 -- 130,429,381(+) CTTCT(C/G)TTCTG intron-variant, upstream-variant-2KB
rs1000211417 -- 130,428,989(+) GCGAC(C/G)CTGTT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS8 Gene

Variant ID Type Subtype PubMed ID
esv2759871 CNV loss 17122850
nsv508660 CNV deletion 20534489
nsv550 CNV insertion 18451855

Variation tolerance for ADAMTS8 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.82; 94.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS8 Gene

Disorders for ADAMTS8 Gene

Relevant External Links for ADAMTS8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADAMTS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS8 Gene

Publications for ADAMTS8 Gene

  1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vazquez F. … Iruela-Arispe M.L. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PMID: 10610729) Georgiadis K.E. … Apte S.S. (Genomics 1999) 3 4 22 64
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
  4. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PMID: 15296936) Collins-Racie L.A. … LaVallie E.R. (Matrix Biol. 2004) 3 22 64
  5. METH-2 silencing and promoter hypermethylation in NSCLC. (PMID: 15328519) Dunn J.R. … Liloglou T. (Br. J. Cancer 2004) 3 22 64

Products for ADAMTS8 Gene

Sources for ADAMTS8 Gene

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