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Aliases for ADAMTS8 Gene

Aliases for ADAMTS8 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 8 2 3
  • METH2 3 4 6
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 8 2 3
  • ADAM-TS 8 3 4
  • ADAM-TS8 3 4
  • ADAMTS-8 3 4
  • METH-2 3 4
  • METH-8 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8 3
  • EC 63
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS8 Gene

Previous GeneCards Identifiers for ADAMTS8 Gene

  • GC11M132275
  • GC11M131787
  • GC11M129812
  • GC11M129780
  • GC11M126229

Summaries for ADAMTS8 Gene

Entrez Gene Summary for ADAMTS8 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS8 Gene

ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 8) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS8 Gene

  • Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS8 Gene

Genomics for ADAMTS8 Gene

Regulatory Elements for ADAMTS8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS8 Gene

130,404,923 bp from pter
130,428,993 bp from pter
24,071 bases
Minus strand

Genomic View for ADAMTS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS8 Gene

Proteins for ADAMTS8 Gene

  • Protein details for ADAMTS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 8
    Protein Accession:
    Secondary Accessions:
    • Q9NZS0

    Protein attributes for ADAMTS8 Gene

    889 amino acids
    Molecular mass:
    96460 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS8 Gene

Proteomics data for ADAMTS8 Gene at MOPED

Selected DME Specific Peptides for ADAMTS8 Gene

Post-translational modifications for ADAMTS8 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn344, Asn400, Asn465, Asn490, and Asn599
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADAMTS8 Gene

Gene Families for ADAMTS8 Gene

  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif

Suggested Antigen Peptide Sequences for ADAMTS8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UP79
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 2 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS8: view

Function for ADAMTS8 Gene

Molecular function for ADAMTS8 Gene

UniProtKB/Swiss-Prot Function:
Has anti-angiogenic properties

Enzyme Numbers (IUBMB) for ADAMTS8 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 10438512
GO:0008201 heparin binding IEA --
GO:0008237 metallopeptidase activity TAS 10438512
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS8: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS8 Gene

Localization for ADAMTS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS8 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTS8 Gene COMPARTMENTS Subcellular localization image for ADAMTS8 gene
Compartment Confidence
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with ADAMTS8: view

Pathways for ADAMTS8 Gene

genes like me logo Genes that share pathways with ADAMTS8: view

Pathways by source for ADAMTS8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ADAMTS8 Gene

Gene Ontology (GO) - Biological Process for ADAMTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008285 negative regulation of cell proliferation TAS 10438512
GO:0035435 phosphate ion transmembrane transport TAS 10610729
genes like me logo Genes that share ontologies with ADAMTS8: view

Transcripts for ADAMTS8 Gene

mRNA/cDNA for ADAMTS8 Gene

Unigene Clusters for ADAMTS8 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - - - - - - - -
SP3: -

Relevant External Links for ADAMTS8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS8 Gene

mRNA expression in normal human tissues for ADAMTS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS8 Gene

This gene is overexpressed in Lung (8.5) and Artery - Aorta (4.1).

Protein differential expression in normal tissues for ADAMTS8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS8 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS8 Gene Hs.271605

mRNA Expression by UniProt/SwissProt for ADAMTS8 Gene

Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney
genes like me logo Genes that share expressions with ADAMTS8: view

Expression partners for ADAMTS8 Gene

In Situ Assay Products

Orthologs for ADAMTS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS8 35
  • 82.92 (n)
  • 76.7 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ADAMTS8 35
  • 88.15 (n)
  • 90.12 (a)
  • 88 (a)
(Mus musculus)
Mammalia Adamts8 35
  • 83.72 (n)
  • 82.44 (a)
Adamts8 16
Adamts8 36
  • 80 (a)
(Pan troglodytes)
Mammalia ADAMTS8 35
  • 99.1 (n)
  • 98.83 (a)
  • 89 (a)
(Rattus norvegicus)
Mammalia Adamts8 35
  • 82.94 (n)
  • 82.55 (a)
(Monodelphis domestica)
Mammalia ADAMTS8 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS8 36
  • 81 (a)
(Gallus gallus)
Aves ADAMTS8 35
  • 76.94 (n)
  • 78.02 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia ADAMTS8 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts8 35
  • 58.75 (n)
  • 58.35 (a)
(Danio rerio)
Actinopterygii adamts8a 35
  • 61.77 (n)
  • 58.4 (a)
adamts15b 36
  • 50 (a)
adamts8a 36
  • 53 (a)
Species with no ortholog for ADAMTS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS8 Gene

Gene Tree for ADAMTS8 (if available)
Gene Tree for ADAMTS8 (if available)

Paralogs for ADAMTS8 Gene

Selected SIMAP similar genes for ADAMTS8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS8: view

Variants for ADAMTS8 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs765386 -- 130,419,713(+) TCTAC(C/T)GGACG intron-variant
rs765387 -- 130,419,340(+) TCTCA(A/G)GGCCC intron-variant
rs903024 -- 130,428,552(-) GGGCA(A/G)GGGCG utr-variant-5-prime
rs1021206 -- 130,406,915(+) TTGCT(C/T)TTCTT intron-variant
rs1552330 -- 130,423,999(+) TTGTC(A/G)CGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS8 Gene

Variant ID Type Subtype PubMed ID
dgv446e1 CNV Complex 17122850
nsv508660 CNV Loss 20534489
nsv550 CNV Insertion 18451855

Relevant External Links for ADAMTS8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS8 Gene

Disorders for ADAMTS8 Gene

Relevant External Links for ADAMTS8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAMTS8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAMTS8 Gene

Publications for ADAMTS8 Gene

  1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vazquez F. … Iruela-Arispe M.L. (J. Biol. Chem. 1999) 2 3 4 23
  2. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PMID: 10610729) Georgiadis K.E. … Apte S.S. (Genomics 1999) 3 4 23
  3. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PMID: 15296936) Collins-Racie L.A. … LaVallie E.R. (Matrix Biol. 2004) 3 23
  4. METH-2 silencing and promoter hypermethylation in NSCLC. (PMID: 15328519) Dunn J.R. … Liloglou T. (Br. J. Cancer 2004) 3 23
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 48

Products for ADAMTS8 Gene

Sources for ADAMTS8 Gene

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