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ADAMTS8 Gene

protein-coding   GIFtS: 54
GCID: GC11M130308

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 81 2     ADAM-TS 82 3
METH22 3 5     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 82
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 81 2
     EC 3.4.24.-3
ADAM-TS82 3     EC 3.4.248
ADAMTS-82 3     EC 3.4.24.148
METH-22 3     EC 3.4.24.828
METH-82 3     

External Ids:    HGNC: 2241   Entrez Gene: 110952   Ensembl: ENSG000001349177   OMIM: 6051755   UniProtKB: Q9UP793   

Export aliases for ADAMTS8 gene to outside databases

Previous GC identifers: GC11M132275 GC11M131787 GC11M129812 GC11M129780 GC11M126229


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS8 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme
encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders
have been mapped in the vicinity of this gene, most notably lung neoplasms. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS8 Gene:
ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif, 8) is a protein-coding gene. GO annotations related to this gene include integrin binding and heparin binding. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
Function: Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS8 gene promoter:
         C/EBPbeta   AML1a   ATF-2   FOXO1a   CUTL1   Hlf   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS8 promoter sequence
   Search Chromatin IP Primers for ADAMTS8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M130308:  view genomic region     (about GC identifiers)

Start:
130,274,818 bp from pter      End:
130,298,888 bp from pter
Size:
24,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor  
Size: 889 amino acids; 96460 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q9NZS0

Explore the universe of human proteins at neXtProt for ADAMTS8: NX_Q9UP79

Explore proteomics data for ADAMTS8 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn344, Asn400, Asn465, Asn490, Asn599
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ADAMTS8 (Q9UP79)
     SCSVIED  DKCGVCGG  CSRTCGGGV  GQCVKAGCD 


    See ADAMTS8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008968.4  
    ENSEMBL proteins: 
     ENSP00000257359  
    Reactome Protein details: Q9UP79

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS8
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UP79

    ProtoNet protein and cluster: Q9UP79

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 2 TSP type-1 domains


    Find genes that share domains with ADAMTS8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS8_HUMAN, Q9UP79
    Function: Has anti-angiogenic properties

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS10438512
    GO:0008201heparin binding IEA--
    GO:0008237metallopeptidase activity TAS10438512
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADAMTS8

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    hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS8 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS8_HUMAN, Q9UP79: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    Find genes that share ontologies with ADAMTS8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAMTS8 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with ADAMTS8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ADAMTS8
        O-glycosylation of TSR domain-containing proteins
    Degradation of the extracellular matrix


        Pathway & Disease-focused RT2 Profiler PCR Array including ADAMTS8: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS8

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008285negative regulation of cell proliferation TAS10438512
    GO:0035435phosphate ion transmembrane transport TAS10610729

    Find genes that share ontologies with ADAMTS8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTS8 (ATS8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMTS8 gene: 
    NM_007037.4  

    Unigene Cluster for ADAMTS8:

    ADAM metallopeptidase with thrombospondin type 1 motif, 8
    Hs.271605  [show with all ESTs]
    Unigene Representative Sequence: AF060153
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531752(uc001qgf.3) ENST00000257359(uc001qgg.4)
    miRNA
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    hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS8 3' UTR sequence
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    Additional mRNA sequence: 

    AB209717.1 AF060153.1 AF175283.1 AK123706.1 BC089435.1 BC113874.1 BC114624.1 

    8 DOTS entries:

    DT.120727753  DT.102826821  DT.91753837  DT.101980577  DT.106087  DT.120727736  DT.106086  DT.100845050 

    Selected AceView cDNA sequences (see all 68):

    BM726460 CO246413 CA440574 CO248849 AI811557 CO393893 CO398765 AK123706 
    BM988619 CF125500 AA693573 BF221873 BQ013052 AA350802 CF126031 AI138443 
    AI587074 CF125370 AW137467 BM972024 BE019887 BX105229 CO247237 CO247416 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                      -     -                       -               
    SP2:                          -     -     -     -     -     -     -     -     -         
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ADAMTS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCAGGCT
    ADAMTS8 Expression
    About this image


    ADAMTS8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Lung (Respiratory System)
    ADAMTS8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271605

    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach
    and fetal brain and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including ADAMTS8: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts81 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 83.72(n)1
    82.44(a)1
      9 (16.49 cM)5
    308061  NM_013906.21  NP_038934.21 
     309425625 
    chicken
    (Gallus gallus)
    Aves ADAMTS81 ADAM metallopeptidase with thrombospondin type 1 motif, more 76.94(n)
    78.02(a)
      769222  XM_001232456.3  XP_001232457.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS86
    ADAM metallopeptidase with thrombospondin type 1 m...
    61(a)
    1 ↔ 1
    GL343197.1(379625-403040)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts81 ADAM metallopeptidase with thrombospondin type 1 motif, more 58.75(n)
    58.35(a)
      100497759  XM_002940639.2  XP_002940685.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adamts8a1 ADAM metallopeptidase with thrombospondin type 1 motif, more 61.77(n)
    58.4(a)
      569618  XM_693015.4  XP_698107.4 


    ENSEMBL Gene Tree for ADAMTS8 (if available)
    TreeFam Gene Tree for ADAMTS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS8 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS52  ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS162  ADAMTS32  ADAMTS102  
    12 SIMAP similar genes for ADAMTS8 using alignment to 3 protein entries:     ATS8_HUMAN (see all proteins):
    TSHZ2    ADAMTS1    DKFZp686E01144    ADAMTS15    ADAMTS4    ADAMTS20
    ADAMTS5    ADAMTS9    ADAMTS13    ADAMTS12    ADAMTS6    ADAMTS7

    Find genes that share paralogs with ADAMTS8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS8 (see all 657)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105488721,2
    C--130167340(+) cagcg-/GCAgcagc 2 R P fra10--------
    rs1492886151,2
    C--130274352(+) TGGCAC/TGAAAA 1 -- int10--------
    rs1165567781,2
    C,F--130274461(+) ATTTCG/ATTTTT 1 -- int11Minor allele frequency- A:0.07WA 118
    rs1159367351,2
    C,F--130274622(+) TCTACG/ATGATC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1846676081,2
    --130274625(+) ACGTGA/GTCCTA 1 -- int10--------
    rs1899111941,2
    --130274679(+) TTGCCC/TGAATG 1 -- int10--------
    rs1474362141,2
    --130274680(+) TGCCCA/GAATGA 1 -- int10--------
    rs1397144251,2
    --130274735(+) CAGCTA/GCTGAC 1 -- int10--------
    rs765803751,2
    C--130274779(+) GCTGCC/TCTTTC 1 -- int14Minor allele frequency- T:0.07CSA WA NA EA 360
    rs777542291,2
    C--130274853(+) CACATT/CTGCAT 1 -- ut312Minor allele frequency- C:0.03WA 120

    HapMap Linkage Disequilibrium report for ADAMTS8 (130274818 - 130298888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADAMTS8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv550CNV Insertion18451855
    nsv508660CNV Loss20534489
    dgv446e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605175    OMIM disorders: --


    Find genes that share disorders with ADAMTS8           About GenesLikeMe

    Genetic Association Database (GAD): ADAMTS8
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS8 (1 document)

    Export disorders for ADAMTS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS8 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ADAMTS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 9 Vazquez F.... Iruela-Arispe M.L. (J. Biol. Chem. 1999)
    2. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PubMed id 10610729)1, 2, 9 Georgiadis K.E.... Apte S.S. (Genomics 1999)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. METH-2 silencing and promoter hypermethylation in NSCLC. (PubMed id 15328519)1, 9 Dunn J.R....Liloglou T. (Br. J. Cancer 2004)
    5. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936)1, 9 Collins-Racie L.A....LaVallie E.R. (Matrix Biol. 2004)
    6. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. (PubMed id 17606262)1 WAYgsAoter D....Eriksson P. (Atherosclerosis 2008)
    7. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)1 Porter S....Edwards D.R. (Int. J. Cancer 2006)
    8. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. (PubMed id 16570050)1 Dunn J.R....Walker C. (Br. J. Cancer 2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11095 HGNC: 224 AceView: ADAMTS8 Ensembl:ENSG00000134917 euGenes: HUgn11095
    ECgene: ADAMTS8 H-InvDB: ADAMTS8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS8 gene:
    Search GeneIP for patents involving ADAMTS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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