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ADAMTS8 Gene

protein-coding GIFtS: 54

GC11M129780

ADAM metallopeptidase with thrombospondin type 1 motif, 8
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADAM-TS8 ^¹, ², ³
ADAMTS-8 ^³
EC 3.4.24.- ^³
FLJ41712 ^¹, ²
METH-2 ^³
METH-8 ^³
METH2 ^¹, ², ³, ⁵

Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 8 ^²
ADAM-TS 8 ^³
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 ^¹, ²

External Ids
HGNC: 224¹
Entrez Gene: 11095²
UniProtKB: Q9UP79³
Ensembl: ENSG00000134917⁷

Search outside databases for aliases for ADAMTS8 gene

Previous GC identifers: GC11M132275 GC11M131787 GC11M130308 GC11M129812

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAMTS8:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin

motifs) protein family. Members of the family share several distinct protein modules, including a

propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin

type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,

and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal

TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the

vicinity of this gene, most notably lung neoplasms. [provided by RefSeq]

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Function: Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAMTS8 gene

Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q25

ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M129780: (about GC identifiers)

Start:	129,780,028 bp from pter
End:	129,803,749 bp from pter
Size:	23,722 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor

Size: 890 amino acids; 96672 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: Q9NZS0

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

REFSEQ proteins: NP_008968.4

ENSEMBL proteins:

ENSP00000257359

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAMTS8)
	Human Recombinant Proteins from Abnova (ADAMTS8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--

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Antibodies for ADAMTS8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADAMTS8
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADAMTS8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAMTS8)
	Novus Biologicals Antibody for ADAMTS8

Assays for ADAMTS8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UP79

ProtoNet protein and cluster: Q9UP79

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the

extracellular matrix

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 2 TSP type-1 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAMTS8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAMTS8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007037

Applied Biosystems Silencer® siRNAs for ADAMTS8

Sigma-Aldrich siRNA and siRNA Panels for ADAMTS8

Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007037
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007037
untagged cDNA clone in CMV expression vector: NM_007037

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007037

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Function: Has anti-angiogenic properties

Enzyme Number (IUBMB): EC 3.4.24.-

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	TAS	10438512
GO:0008201	heparin binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	10438512

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAMTS8

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAMTS8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAMTS8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAMTS8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007037

Sigma-Aldrich siRNA and siRNA Panels for ADAMTS8

Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007037

REFSEQ mRNAs for ADAMTS8 gene:

NM_007037.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007037

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007037
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007037
                                 untagged cDNA clone in CMV expression vector: NM_007037

Additional cDNA sequence:

AB209717.1 AF060153.1 AF175283.1 AK123706.1 BC089435.1 BC113874.1 BC114624.1

8 DOTS entries:

DT.120727753 DT.102826821 DT.91753837 DT.101980577 DT.106087 DT.120727736 DT.106086 DT.100845050

24/68 AceView cDNA sequences (see all 68 ):

CO248849 CA440574 BM988619 AI811557 AA693573 BF221873 CO393893 AI138443

CO398765 CF125500 AA350802 AK123706 CF126031 BM726460 BQ013052 CO246413

AI969885 CO401291 AA917316 BM972024 CO246592 CF125909 AI378857 AI587074

highest scoring ESTs for ADAMTS8:

AF060153 AI400905 AA350802 AA635657 AF175283 AI378857 AI674956 AI969885 AW137467 BF033017

Unigene Cluster for ADAMTS8:

ADAM metallopeptidase with thrombospondin type 1 motif, 8

Hs.271605 [show with all ESTs]

Unigene Representative Sequence: AF060153

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10
SP1:													-		-								-
SP2:									-		-		-		-		-		-		-		-		-
SP3:																							-
SP4:

About this scheme

ECgene alternative splicing isoforms for ADAMTS8

1 Ensembl transcript including schematic representation:

ENST00000257359

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADAMTS8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS8

¹ / ² / ³

8 probe-sets matching ADAMTS8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88879_at²^{, 3}	U95-E	1	1.00	1.00	0.85	1.14	AI378857	0.60	1.00	0.82	1
85346_at²^{, 3}	U95-E	1	0.81	1.00	0.34	0.87	AI400905	0.80	1.00	0.91	1
235649_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW207389	0.40	1.00	0.76	1
220676_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007037	0.60	1.00	0.82	1
220677_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007037	0.60	1.00	0.82	1
235649_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220676_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220677_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADAMTS8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCTCAGGCT

SOURCE GeneReport for Unigene cluster: Hs.271605
UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta,
heart, stomach and fetal brain and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAMTS8 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	99.06(n) 98.87(a)	466852 XM_522252.2 XP_522252.2
cow (Bos taurus)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	82.9(n) 76.9(a)	512544 XM_590083.3 XP_590083.3
rat (Rattus norvegicus)	Adamts8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	82.24(n) 78.92(a)	300475 XM_235977.4 XP_235977.4
mouse (Mus musculus)	Adamts8^{1, 5}	9 (9.00 cM)⁵	a disintegrin-like and metallopeptidase (reprolysin more^{1, 5}	83.61(n)¹ 81.55(a)¹	30806¹ NM_013906.2¹ NP_038934.2¹ AA855532⁵ AF175282⁵ (see all 8)
chicken (Gallus gallus)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	76.5(n) 76.74(a)	769222 XM_001232456.1 XP_001232457.1

About this table Species with no ortholog for ADAMTS8

ENSEMBL Gene Tree for ADAMTS8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAMTS8 gene

ADAMTS4² ADAMTS1² ADAMTS5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/158 NCBI SNPs in ADAMTS8 are shown (see all 158 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2131535^1,2	A,C,F,H	129786698(+)	`CATCTA/GCCACG`	1	A/V	mis¹ ese³		16		EA NA EU WA	2784
	rs3758822^1,2	C,F,H	129805195(-)	`TTGTCC/TTTCCT`	1	--	ng3¹ trp³		5		EA EU WA	1502
	rs2242312^1,2	C,F,H	129780556(+)	`GGGCCG/ATGCTG`	1	--	ut3¹ ese³		5		EA EU WA	1170
	rs11821301^1,2	C,F,H	129804878(+)	`GGGGAT/CGTTGA`	1	--	ng3¹		2		EU WA	238
	rs2291348^1,2	C,F,H	129794327(+)	`TCAGGT/CTGATG`	1	S/N	mis¹		10		EA EU WA NA	2362
	rs11222085^1,2	C,F,H	129780959(+)	`GACTGT/CCAGGA`	1	A/T	mis¹ ese³		9		EU EA WA NA	908
	rs903024^1,2	A,F	129803657(-)	`GGGCAA/GGGGCG`	1	--	ut5¹		1		MN	184
	rs35468629^1,2	F	129802958(+)	`GCTGAG/CCCAGG`	1	G/A	mis¹		1		NA	74
	rs7927048^1,2	A	129803158(+)	`TTGAAC/GTCGGG`	1	E/D	mis¹		0	--	--	--	--
	rs12289835^1,2	H	129802745(+)	`CCTCAG/AACACA`	1	F/S	mis¹ ese³		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for ADAMTS8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605175

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/11 PubMed articles for ADAMTS8 gene (see all 11 ):

METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)^{1, 2, 3, 4} Vazquez F.... Iruela-Arispe M.L. (1999)
ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PubMed id 10610729)^{1, 3, 4} Georgiadis K.E.... Apte S.S. (1999)
METH-2 silencing and promoter hypermethylation in NSCLC. (PubMed id 15328519)^{1, 3} Dunn J.R....Liloglou T. (2004)
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936)^{1, 3} Collins-Racie L.A....LaVallie E.R. (2004)
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. (PubMed id 17606262)³ Wagsater D....Eriksson P. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)³ Porter S....Edwards D.R. (2006)
Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. (PubMed id 16570050)³ Dunn J.R....Walker C. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 11095	HGNC: 224	AceView: ADAMTS8	Ensembl:ENSG00000134917	euGenes: HUgn11095
ECgene: ADAMTS8	H-InvDB: ADAMTS8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ADAMTS8	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ADAMTS8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADAMTS8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAMTS8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAMTS8		Antibodies for ADAMTS8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAMTS8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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ADAMTS8 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for ADAMTS8

Summaries
for ADAMTS8

Genomic Location
for ADAMTS8

Proteins
for ADAMTS8

Protein Domains/
Families
for ADAMTS8

Gene Function
for ADAMTS8

Pathways & Interactions
for ADAMTS8

Drugs & Compounds
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Transcripts
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Expression
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Orthologs
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Medical News
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Genome Databases showing ADAMTS8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAMTS8 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor ADAMTS8

Summariesfor ADAMTS8

Genomic Locationfor ADAMTS8

Proteinsfor ADAMTS8

Protein Domains/Familiesfor ADAMTS8

Gene Functionfor ADAMTS8

Pathways & Interactionsfor ADAMTS8

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Transcriptsfor ADAMTS8

Expression for ADAMTS8

Orthologsfor ADAMTS8

Paralogsfor ADAMTS8

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Disorders & Mutationsfor ADAMTS8

Medical Newsfor ADAMTS8

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Search for ADAMTS8

Genome Databases showing ADAMTS8

Other Databases showing ADAMTS8

Specialized Databases showing ADAMTS8

Licensable Technologiesfor ADAMTS8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAMTS8

Summaries
for ADAMTS8

Genomic Location
for ADAMTS8

Proteins
for ADAMTS8

Protein Domains/
Families
for ADAMTS8

Gene Function
for ADAMTS8

Pathways & Interactions
for ADAMTS8

Drugs & Compounds
for ADAMTS8

Transcripts
for ADAMTS8

Expression
for ADAMTS8

Orthologs
for ADAMTS8

Paralogs
for ADAMTS8

SNPs/Variants
for ADAMTS8

Disorders & Mutations
for ADAMTS8

Medical News
for ADAMTS8

Publications
for ADAMTS8

Licensable Technologies
for ADAMTS8

Services
for ADAMTS8