Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS8 Gene

protein-coding   GIFtS: 50
GCID: GC11M130308

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 4 diseases affiliated with
ADAMTS8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS8    

Aliases
for ADAMTS8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 81 2     ADAM-TS 82 3
METH21 2 3 5     FLJ417121
ADAM-TS81 2 3     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 82
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 81 2
     EC 3.4.24.-3
ADAMTS-82 3     EC 3.4.248
METH-22 3     EC 3.4.24.148
METH-82 3     EC 3.4.24.828

External Ids:    HGNC: 2241   Entrez Gene: 110952   Ensembl: ENSG000001349177   OMIM: 6051755   UniProtKB: Q9UP793   

Export aliases for ADAMTS8 gene to outside databases

Previous GC identifers: GC11M132275 GC11M131787 GC11M129812 GC11M129780 GC11M126229


Summaries
for ADAMTS8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS8:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded
by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been
mapped in the vicinity of this gene, most notably lung neoplasms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
Function: Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8


Genomic Views
for ADAMTS8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS8 gene promoter:
         C/EBPbeta   AML1a   ATF-2   FOXO1a   CUTL1   Hlf   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M130308:  view genomic region     (about GC identifiers)

Start:
 130,274,818 bp from pter      End:
 130,298,888 bp from pter
Size:
 24,071 bases      Orientation:
 minus strand

Proteins
for ADAMTS8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor  
Size: 889 amino acids; 96460 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q9NZS0

Explore the universe of human proteins at neXtProt for ADAMTS8: NX_Q9UP79

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UP79

    • 4 DME Specific Peptides for ADAMTS8 (Q9UP79)
     SCSVIED  DKCGVCGG  CSRTCGGGV  GQCVKAGCD 

    ADAMTS8 Protein expression data from MOPED and PaxDb:    About this image 
    ADAMTS8 Protein Expression
    REFSEQ proteins: NP_008968.4  
    ENSEMBL proteins: 
     ENSP00000257359  

    Human Recombinant Protein Products for ADAMTS8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ADAMTS8
    OriGene Protein Over-expression Lysate: ADAMTS8
    OriGene Custom Protein Services for ADAMTS8 
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS8
    Novus Biologicals ADAMTS8 Protein
    Novus Biologicals ADAMTS8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAMTS8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    ADAMTS8 for ontologies           About GeneDecksing



    ADAMTS8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ADAMTS8
    OriGene Antibodies (see all 2): ADAMTS8
    OriGene Custom Antibody Services for ADAMTS8 
    GenScript Custom Superior Antibodies Services for ADAMTS8
    Novus Biologicals ADAMTS8 Antibody
    Abcam antibodies for ADAMTS8 
    Uscn Antibodies for ADAMTS8
    Search ThermoFisher Antibodies for ADAMTS8

    Assay Products for ADAMTS8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTS8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAMTS8

    Protein Domains /
    Families
    for ADAMTS8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS8 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR013277 Pept_M12B_ADAM-TS8

    Graphical View of Domain Structure for InterPro Entry Q9UP79

    ProtoNet protein and cluster: Q9UP79

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 2 TSP type-1 domains


    Function
    for ADAMTS8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS8_HUMAN, Q9UP79
    Function: Has anti-angiogenic properties

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS10438512
    GO:0008201heparin binding IEA--
    GO:0008237metallopeptidase activity TAS10438512
    GO:0008270zinc ion binding IEA--
         
    ADAMTS8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS8 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ADAMTS8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS8
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS8 (see all 18):
    hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS8 (see all 7)
    OriGene shRNA RFP: ADAMTS8
    OriGene siRNA: ADAMTS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS8
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTS8 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADAMTS8
    Sirion Biotech Customized adenovirus for overexpression of ADAMTS8 
    Sirion Biotech Customized adenovirus for potent knockdown of ADAMTS8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTS8 (NM_007037)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS8
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ADAMTS8
    Search LifeMap BioReagents cell lines for ADAMTS8
    Sirion Biotech Customized stable knockdown cell line services for ADAMTS8 
    Sirion Biotech Customized inducible knockdown cell line services for ADAMTS8
    Sirion Biotech Customized stable overexpressing cell line services for ADAMTS8
    Sirion Biotech Customized inducible overexpressing cell line services for ADAMTS8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS8


    Pathways & Interactions
    for ADAMTS8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS8

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0008285negative regulation of cell proliferation TAS10438512

    ADAMTS8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS8
    Search CenterWatch for drugs/clinical trials and news about ADAMTS8 / ATS8 

    Transcripts
    for ADAMTS8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS8 gene: 
    NM_007037.4  

    Unigene Cluster for ADAMTS8:

    ADAM metallopeptidase with thrombospondin type 1 motif, 8
    Hs.271605  [show with all ESTs]
    Unigene Representative Sequence: AF060153
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531752(uc001qgf.3) ENST00000257359(uc001qgg.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ADAMTS8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS8
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS8 (see all 18):
    hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS8 (see all 7)
    OriGene shRNA RFP: ADAMTS8
    OriGene siRNA: ADAMTS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS8
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTS8 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTS8 (NM_007037)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS8
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS8

    Additional cDNA sequence: 

    AB209717.1 AF060153.1 AF175283.1 AK123706.1 BC089435.1 BC113874.1 BC114624.1 

    8 DOTS entries:

    DT.120727753  DT.102826821  DT.91753837  DT.101980577  DT.106087  DT.120727736  DT.106086  DT.100845050 

    24/68 AceView cDNA sequences (see all 68):

    CF126031 CO393893 AK123706 CA440574 CF125500 CO248849 BF221873 BQ013052 
    AA693573 CO246413 BM988619 BM726460 CO398765 AI811557 AA350802 AI138443 
    AI587074 BI819909 CO246592 BE019887 CO247237 AI400905 CN480499 AW137467 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                      -     -                       -               
    SP2:                          -     -     -     -     -     -     -     -     -         
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ADAMTS8

    Expression
    for ADAMTS8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTCAGGCT
    ADAMTS8 Expression
    About this image

    ADAMTS8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ADAMTS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS8

    SOURCE GeneReport for Unigene cluster: Hs.271605

    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and
    fetal brain and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including ADAMTS8: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS8

    Orthologs
    for ADAMTS8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS8 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS81 ADAM metallopeptidase with thrombospondin type 1 motif, more 76.56(n)
    77.58(a)    		   769222  XM_001232456.2  XP_001232457.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAMTS86
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343197.1(379625-402413)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5696181 novel protein similar to vertebrate ADAM metallopeptidase more 61.67(n)
    58.17(a)    		   569618  XM_693015.3  XP_698107.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG148696
    		 --
    		 15(a)
    		 1 → many
    		 3R(11267965-11301915)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-176
    gon-16
    		 ADAM family mig-17
    A disintegrin and metalloproteinase with thrombosp...
    		 16(a)
    14(a)
    		 possible ortholog
    1 ↔ many
    		 V(11446634-11449228)
    IV(9935046-9945754)


    ENSEMBL Gene Tree for ADAMTS8 (if available)
    TreeFam Gene Tree for ADAMTS8 (if available) 

    Paralogs
    for ADAMTS8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS8 gene
    ADAMTS172  ADAMTS182  ADAMTS62  ADAMTS122  ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS92  
    ADAMTS162  ADAMTS102  ADAMTS72  ADAMTS12  ADAMTS192  ADAMTS142  ADAMTS22  ADAMTS152  
    ADAMTS32  
    15 SIMAP similar genes for ADAMTS8 using alignment to 3 protein entries:     ATS8_HUMAN (see all proteins):
    TSHZ2    ADAMTS1    DKFZp686E01144    ADAMTS15    ADAMTS4    ADAMTS20
    ADAMTS5    ADAMTS9    ADAMTS13    ADAMTS12    ADAMTS6    ADAMTS7
    ADAMTS18    ADAMTS2    ADAMTS3

    ADAMTS8 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 NCBI SNPs in ADAMTS8 are shown (see all 498)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1492886151,2
    		--130274352(+) TGGCAC/TGAAAA 1 -- int10--------
    rs1165567781,2
    		F--130274461(+) ATTTCG/ATTTTT 1 -- int11Minor allele frequency- A:0.07WA 118
    rs1159367351,2
    		F--130274622(+) TCTACG/ATGATC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1846676081,2
    		--130274625(+) ACGTGA/GTCCTA 1 -- int10--------
    rs1899111941,2
    		--130274679(+) TTGCCC/TGAATG 1 -- int10--------
    rs1474362141,2
    		--130274680(+) TGCCCA/GAATGA 1 -- int10--------
    rs1397144251,2
    		--130274735(+) CAGCTA/GCTGAC 1 -- int10--------
    rs765803751,2
    		C--130274779(+) GCTGCC/TCTTTC 1 -- int14Minor allele frequency- T:0.07CSA WA NA EA 360
    rs777542291,2
    		C--130274853(+) CACATT/CTGCAT 1 -- ut312Minor allele frequency- C:0.03WA 120
    rs1160786961,2
    		--130274970(+) ACAGTC/TGTGGT 1 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ADAMTS8 (130274818 - 130298888 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ADAMTS8
         1 CNV: 3869

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS8
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS8

    Disorders / Diseases
    for ADAMTS8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS8 for disorders           About GeneDecksing

    OMIM gene information: 605175    OMIM disorders: --

    4 diseases for ADAMTS8:    About MalaCards
    lung neoplasm    chondrosarcoma    breast carcinoma    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS8 (1 document)

    Export disorders for ADAMTS8 gene to outside databases

    Publications
    for ADAMTS8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS8 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ADAMTS8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 9 Vazquez F.... Iruela-Arispe M.L. (1999)
    2. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PubMed id 10610729)1, 2, 9 Georgiadis K.E.... Apte S.S. (1999)
    3. METH-2 silencing and promoter hypermethylation in NSCLC. (PubMed id 15328519)1, 9 Dunn J.R....Liloglou T. (2004)
    4. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936)1, 9 Collins-Racie L.A....LaVallie E.R. (2004)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1 Joslyn G....White R.L. (2010)
    6. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. (PubMed id 17606262)1 Wagsater D....Eriksson P. (2008)
    7. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)1 Porter S....Edwards D.R. (2006)
    8. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. (PubMed id 16570050)1 Dunn J.R....Walker C. (2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for ADAMTS8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAMTS8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11095 HGNC: 224 AceView: ADAMTS8 Ensembl:ENSG00000134917 euGenes: HUgn11095
    ECgene: ADAMTS8 H-InvDB: ADAMTS8

    Other Databases showing ADAMTS8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMTS8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS8 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAMTS8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS8 gene:
    Search GeneIP for patents involving ADAMTS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ADAMTS8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ADAMTS8 (ADAMTS8)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ADAMTS8   OriGene shRNA RFP for ADAMTS8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS8  
     OriGene Protein Over-expression Lysate for ADAMTS8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ADAMTS8   OriGene 3'-UTR Clone for ADAMTS8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ADAMTS8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS8   OriGene Custom Protein Services for ADAMTS8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS8
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS8 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS8
     GenScript Custom Assay Services for ADAMTS8 GenScript Custom Superior Antibodies Services for ADAMTS8
     GenScript Custom overexpressing Cell Line Services for ADAMTS8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAMTS8 promoter
     Search Chromatin IP Primers for ADAMTS8
     RT2 qPCR Primer Assay in human, mouse, rat ADAMTS8
     Search GNC Networks for ADAMTS8
     SABiosciences PCR Arrays including human, mouse, rat ADAMTS8
     Search Tocris compounds for ADAMTS8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAMTS8 antibodies
     ADAMTS8 proteins
     ADAMTS8 lysates
     Antibodies for ADAMTS8
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ADAMTS8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ADAMTS8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS8
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS8
     SwitchGear Promoter luciferase reporter plasmids for ADAMTS8
     Search ThermoFisher Antibodies for ADAMTS8
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS8
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS8
    Sirion Biotech Customized:
     stable knockdown cell line services for ADAMTS8
     inducible knockdown cell line services for ADAMTS8
     design and validation of potent shRNA sequences against ADAMTS8
     adenovirus for potent knockdown of ADAMTS8
     adenovirus for overexpression of ADAMTS8
     stable overexpressing cell line services for ADAMTS8
     inducible overexpressing cell line services for ADAMTS8
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ADAMTS8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4