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Aliases for ADAMTS7 Gene

Aliases for ADAMTS7 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7 2 3 5
  • COMPase 2 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 7 2 3
  • A Disintegrin And Metalloprotease With Thrombospondin Motifs-7 Preproprotein 2 3
  • ADAM-TS 7 3 4
  • ADAM-TS7 3 4
  • ADAMTS-7 3 4
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS7 Gene

Previous GeneCards Identifiers for ADAMTS7 Gene

  • GC15P074116
  • GC15M072142
  • GC15M076627
  • GC15M076767
  • GC15M076839
  • GC15M079051
  • GC15M055809

Summaries for ADAMTS7 Gene

Entrez Gene Summary for ADAMTS7 Gene

  • The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS7 Gene

ADAMTS7 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7) is a Protein Coding gene. Diseases associated with ADAMTS7 include Artery Disease. Among its related pathways are Infectious disease and Diseases associated with O-glycosylation of proteins. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS20.

UniProtKB/Swiss-Prot for ADAMTS7 Gene

  • Metalloprotease that may play a role in the degradation of COMP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS7 Gene

Genomics for ADAMTS7 Gene

Regulatory Elements for ADAMTS7 Gene

Enhancers for ADAMTS7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS7 on UCSC Golden Path with GeneCards custom track

Promoters for ADAMTS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS7 Gene

78,759,203 bp from pter
78,811,464 bp from pter
52,262 bases
Minus strand

Genomic View for ADAMTS7 Gene

Genes around ADAMTS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS7 Gene

Proteins for ADAMTS7 Gene

  • Protein details for ADAMTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 7
    Protein Accession:
    Secondary Accessions:
    • Q14F51
    • Q6P7J9

    Protein attributes for ADAMTS7 Gene

    1686 amino acids
    Molecular mass:
    184095 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with COMP.
    • Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ADAMTS7 Gene

Proteomics data for ADAMTS7 Gene at MOPED

Selected DME Specific Peptides for ADAMTS7 Gene

Post-translational modifications for ADAMTS7 Gene

  • May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.
  • N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.
  • Glycosylation at Asn 94, Asn 693, Asn 778, Ser 1129, and Thr 1214
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADAMTS7 Gene

Gene Families for ADAMTS7 Gene

Suggested Antigen Peptide Sequences for ADAMTS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 8 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS7: view

Function for ADAMTS7 Gene

Molecular function for ADAMTS7 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular matrix protein
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is between 7.5 and 9.5. {ECO:0000269 PubMed:16585064};
UniProtKB/Swiss-Prot Function:
Metalloprotease that may play a role in the degradation of COMP.
UniProtKB/Swiss-Prot Induction:
Up-regulated in articular cartilage and synovium from arthritis patients.

Enzyme Numbers (IUBMB) for ADAMTS7 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 18485748
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS7: view
genes like me logo Genes that share phenotypes with ADAMTS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS7

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMTS7 Gene

Localization for ADAMTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS7 Gene

Secreted, extracellular space, extracellular matrix. Note=Also found associated with the external cell surface. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ADAMTS7 Gene COMPARTMENTS Subcellular localization image for ADAMTS7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ADAMTS7 Gene

Pathways & Interactions for ADAMTS7 Gene

genes like me logo Genes that share pathways with ADAMTS7: view

Interacting Proteins for ADAMTS7 Gene

Gene Ontology (GO) - Biological Process for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0006508 proteolysis IEA --
GO:0036066 protein O-linked fucosylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ADAMTS7: view

No data available for SIGNOR curated interactions for ADAMTS7 Gene

Drugs & Compounds for ADAMTS7 Gene

No Compound Related Data Available

Transcripts for ADAMTS7 Gene

Unigene Clusters for ADAMTS7 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS7 Gene

No ASD Table

Relevant External Links for ADAMTS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS7 Gene

mRNA expression in normal human tissues for ADAMTS7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS7 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.7).

Protein differential expression in normal tissues from HIPED for ADAMTS7 Gene

This gene is overexpressed in Gallbladder (42.6) and Platelet (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS7 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS7 Gene Hs.16441

mRNA Expression by UniProt/SwissProt for ADAMTS7 Gene

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
genes like me logo Genes that share expression patterns with ADAMTS7: view

Protein tissue co-expression partners for ADAMTS7 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAMTS7 Gene

Orthologs for ADAMTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS7 35
  • 82.43 (n)
  • 79.01 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ADAMTS7 35
  • 83.85 (n)
  • 82.17 (a)
  • 81 (a)
(Mus musculus)
Mammalia Adamts7 35
  • 78.08 (n)
  • 74.07 (a)
Adamts7 16
Adamts7 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Adamts7 35
  • 78.56 (n)
  • 74.17 (a)
(Monodelphis domestica)
Mammalia ADAMTS7 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS7 36
  • 81 (a)
(Pan troglodytes)
Mammalia ADAMTS7 36
  • 98 (a)
(Gallus gallus)
Aves ADAMTS7 35
  • 64.23 (n)
  • 61.56 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia ADAMTS7 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts7 35
  • 62.63 (n)
  • 64.08 (a)
(Danio rerio)
Actinopterygii LOC560364 35
  • 61.59 (n)
  • 60.23 (a)
CT030048.2 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3622 37
  • 25 (a)
CG4096 37
  • 38 (a)
CG4096 35
  • 52.89 (n)
  • 41.21 (a)
CG4096 36
  • 36 (a)
stl 36
  • 21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001113 35
  • 51.82 (n)
  • 41.75 (a)
(Caenorhabditis elegans)
Secernentea T19D2.1 37
  • 27 (a)
adt-2 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ADAMTS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS7 Gene

Gene Tree for ADAMTS7 (if available)
Gene Tree for ADAMTS7 (if available)

Paralogs for ADAMTS7 Gene

(8) SIMAP similar genes for ADAMTS7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS7: view

Variants for ADAMTS7 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3825807 - 78,796,769(-) TGGAG(C/T)CTCGA reference, missense
rs2127898 - 78,790,778(-) GATCA(C/T)GCACC reference, missense
rs11630236 - 78,765,956(+) TGGGG(C/T)TGGGA reference, missense
rs2929155 - 78,765,671(+) CCAGC(C/T)GGCGT reference, missense
rs7495616 - 78,762,558(+) AGGGG(A/C/G)CTGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS7 Gene

Variant ID Type Subtype PubMed ID
nsv904431 CNV Loss 21882294
esv33573 CNV Gain+Loss 17666407
nsv904432 CNV Loss 21882294
esv1505425 CNV Insertion 17803354
nsv94789 CNV Insertion 16902084
dgv345e201 CNV Deletion 23290073
esv2665394 CNV Deletion 23128226
esv994389 CNV Deletion 20482838
esv2749916 CNV Deletion 23290073
esv988480 CNV Insertion 20482838

Variation tolerance for ADAMTS7 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADAMTS7 Gene

Disorders for ADAMTS7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAMTS7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
artery disease
  • arteriopathic disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAMTS7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADAMTS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS7 Gene

Publications for ADAMTS7 Gene

  1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PMID: 10464288) Hurskainen T.L. … Apte S.S. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PMID: 19098927) Liu C.J. (Nat Clin Pract Rheumatol 2009) 3 23
  3. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PMID: 18485748) Luan Y. … Liu C.-J. (Osteoarthritis Cartilage 2008) 3 23
  4. ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- I+ and NF- I_ B P65. (PMID: 25653475) Li J.K. … Nie L. (Mediators Inflamm. 2015) 3
  5. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. (PMID: 25712206) Bauer R.C. … Reilly M.P. (Circulation 2015) 3

Products for ADAMTS7 Gene

Sources for ADAMTS7 Gene