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Aliases for ADAMTS7 Gene

Aliases for ADAMTS7 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 7 2 3
  • COMPase 2 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 7 2 3
  • A Disintegrin And Metalloprotease With Thrombospondin Motifs-7 Preproprotein 2 3
  • ADAM-TS 7 3 4
  • ADAM-TS7 3 4
  • ADAMTS-7 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 3
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS7 Gene

Previous GeneCards Identifiers for ADAMTS7 Gene

  • GC15P074116
  • GC15M072142
  • GC15M076627
  • GC15M076767
  • GC15M076839
  • GC15M079051
  • GC15M055809

Summaries for ADAMTS7 Gene

Entrez Gene Summary for ADAMTS7 Gene

  • The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS7 Gene

ADAMTS7 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 7) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTSL1.

UniProtKB/Swiss-Prot for ADAMTS7 Gene

  • Metalloprotease that may play a role in the degradation of COMP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS7 Gene

Genomics for ADAMTS7 Gene

Regulatory Elements for ADAMTS7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS7 Gene

78,759,203 bp from pter
78,811,463 bp from pter
52,261 bases
Minus strand

Genomic View for ADAMTS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS7 Gene

Proteins for ADAMTS7 Gene

  • Protein details for ADAMTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 7
    Protein Accession:
    Secondary Accessions:
    • Q14F51
    • Q6P7J9

    Protein attributes for ADAMTS7 Gene

    1686 amino acids
    Molecular mass:
    184095 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with COMP.
    • Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ADAMTS7 Gene

Proteomics data for ADAMTS7 Gene at MOPED

Selected DME Specific Peptides for ADAMTS7 Gene

Post-translational modifications for ADAMTS7 Gene

  • May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.
  • N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.
  • Glycosylation at Asn94, Asn693, Asn778, Ser1129, Ser1131, Ser1135, and Thr1214
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADAMTS7 Gene

Gene Families for ADAMTS7 Gene

  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif

Suggested Antigen Peptide Sequences for ADAMTS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UKP4
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 8 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS7: view

Function for ADAMTS7 Gene

Molecular function for ADAMTS7 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular matrix protein
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is between 7.5 and 9.5. {ECO:0000269 PubMed:16585064};
UniProtKB/Swiss-Prot Function:
Metalloprotease that may play a role in the degradation of COMP.
UniProtKB/Swiss-Prot Induction:
Up-regulated in articular cartilage and synovium from arthritis patients.

Enzyme Numbers (IUBMB) for ADAMTS7 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 18485748
GO:0005515 protein binding IPI 18485748
GO:0008233 peptidase activity --
GO:0008237 metallopeptidase activity TAS 10464288
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS7

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS7 Gene

Localization for ADAMTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS7 Gene

Secreted, extracellular space, extracellular matrix. Note=Also found associated with the external cell surface. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ADAMTS7 Gene COMPARTMENTS Subcellular localization image for ADAMTS7 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0009986 cell surface IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS7: view

Pathways for ADAMTS7 Gene

SuperPathways for ADAMTS7 Gene

No Data Available

Interacting Proteins for ADAMTS7 Gene

Gene Ontology (GO) - Biological Process for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0006508 proteolysis --
GO:0032331 negative regulation of chondrocyte differentiation IDA 22247065
GO:0036066 protein O-linked fucosylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ADAMTS7: view

No data available for Pathways by source for ADAMTS7 Gene

Transcripts for ADAMTS7 Gene

Unigene Clusters for ADAMTS7 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS7 Gene

No ASD Table

Relevant External Links for ADAMTS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS7 Gene

mRNA expression in normal human tissues for ADAMTS7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS7 Gene

This gene is overexpressed in Heart - Atrial Appendage (8.7).

Protein differential expression in normal tissues for ADAMTS7 Gene

This gene is overexpressed in Gallbladder (42.6) and Platelet (21.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAMTS7 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS7 Gene Hs.16441

mRNA Expression by UniProt/SwissProt for ADAMTS7 Gene

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
genes like me logo Genes that share expressions with ADAMTS7: view

Expression partners for ADAMTS7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAMTS7 Gene

Orthologs for ADAMTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS7 35
  • 82.43 (n)
  • 79.01 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ADAMTS7 35
  • 83.85 (n)
  • 82.17 (a)
  • 81 (a)
(Mus musculus)
Mammalia Adamts7 35
  • 78.08 (n)
  • 74.07 (a)
Adamts7 16
Adamts7 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Adamts7 35
  • 78.56 (n)
  • 74.17 (a)
(Monodelphis domestica)
Mammalia ADAMTS7 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS7 36
  • 81 (a)
(Pan troglodytes)
Mammalia ADAMTS7 36
  • 98 (a)
(Gallus gallus)
Aves ADAMTS7 35
  • 64.23 (n)
  • 61.56 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia ADAMTS7 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts7 35
  • 62.63 (n)
  • 64.08 (a)
(Danio rerio)
Actinopterygii LOC560364 35
  • 61.59 (n)
  • 60.23 (a)
CT030048.2 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3622 37
  • 25 (a)
CG4096 37
  • 38 (a)
CG4096 35
  • 52.89 (n)
  • 41.21 (a)
CG4096 36
  • 36 (a)
stl 36
  • 21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001113 35
  • 51.82 (n)
  • 41.75 (a)
(Caenorhabditis elegans)
Secernentea T19D2.1 37
  • 27 (a)
adt-2 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ADAMTS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS7 Gene

Gene Tree for ADAMTS7 (if available)
Gene Tree for ADAMTS7 (if available)

Paralogs for ADAMTS7 Gene

Selected SIMAP similar genes for ADAMTS7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS7: view

Variants for ADAMTS7 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12286 -- 78,759,417(+) CTGGC(A/G)CAGTC utr-variant-3-prime, downstream-variant-500B
rs922693 -- 78,807,196(-) GCTCC(C/T)CCAGT intron-variant
rs1021069 -- 78,781,414(-) CCAAG(C/G)TCCTT intron-variant
rs1045121 -- 78,759,538(-) GAGAC(A/G)CTGCG synonymous-codon, reference, utr-variant-3-prime
rs1045126 -- 78,759,433(-) CGGGT(C/T)GCCCG synonymous-codon, reference, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS7 Gene

Variant ID Type Subtype PubMed ID
nsv904431 CNV Loss 21882294
esv33573 CNV Gain+Loss 17666407
nsv904432 CNV Loss 21882294
esv1505425 CNV Insertion 17803354
nsv94789 CNV Insertion 16902084
dgv345e201 CNV Deletion 23290073
esv2665394 CNV Deletion 23128226
esv994389 CNV Deletion 20482838
esv2749916 CNV Deletion 23290073
esv988480 CNV Insertion 20482838

Relevant External Links for ADAMTS7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS7 Gene

Disorders for ADAMTS7 Gene

Relevant External Links for ADAMTS7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAMTS7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAMTS7 Gene

Publications for ADAMTS7 Gene

  1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PMID: 10464288) Hurskainen T.L. … Apte S.S. (J. Biol. Chem. 1999) 2 3 4 23
  2. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. (PMID: 16585064) Liu C.-J. … Di Cesare P.E. (FASEB J. 2006) 3 4
  3. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PMID: 19098927) Liu C.J. (Nat Clin Pract Rheumatol 2009) 3 23
  4. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PMID: 18485748) Luan Y. … Liu C.-J. (Osteoarthritis Cartilage 2008) 3 23
  5. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H. … Samani N.J. (Nat. Genet. 2011) 3 48

Products for ADAMTS7 Gene

Sources for ADAMTS7 Gene

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