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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS7 Gene

protein-coding   GIFtS: 49
GCID: GC15M079051

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 71 2     ADAM-TS 72 3
COMPase1 2 3     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 72
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 71 2
     EC 3.4.24.-3
A Disintegrin And Metalloprotease With Thrombospondin Motifs-7
Preproprotein1 2
     EC 3.4.248
ADAM-TS72 3     EC 3.4.24.828
ADAMTS-72 3     

External Ids:    HGNC: 2231   Entrez Gene: 111732   Ensembl: ENSG000001363787   OMIM: 6050095   UniProtKB: Q9UKP43   

Export aliases for ADAMTS7 gene to outside databases

Previous GC identifers: GC15P074116 GC15M072142 GC15M076627 GC15M076767 GC15M076839 GC15M055809


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS7 Gene:
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with
thrombospondin motifs) family. Members of this family share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal
domains. The protein encoded by this gene contains two C-terminal TS motifs. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS7 Gene: 
ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7) is a protein-coding gene. Diseases associated with ADAMTS7 include gigantism, and myocardial infarction. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTSL4.

UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
Function: Metalloprotease that may play a role in the degradation of COMP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS7 gene promoter:
         AhR   Sox5   NF-1   NF-1/L   Elk-1   Sp1   MAZR   Cdc5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ADAMTS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M079051:  view genomic region     (about GC identifiers)

Start:
79,051,545 bp from pter      End:
79,103,773 bp from pter
Size:
52,229 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor  
Size: 1686 amino acids; 184095 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with COMP
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found
associated with the external cell surface (By similarity)
Sequence caution: Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q14F51 Q6P7J9

Explore the universe of human proteins at neXtProt for ADAMTS7: NX_Q9UKP4

Explore proteomics data for ADAMTS7 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated
    proteoglycan. Contains chondroitin sulfate
  • UniProtKB: May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKP4

  • 4/9 DME Specific Peptides for ADAMTS7 (Q9UKP4) (see all 9)
     LRPFHCQ  EEEAPEL  EDRCGVC  LTSPGPT 

    ADAMTS7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS7 Protein Expression
    REFSEQ proteins: NP_055087.2  
    ENSEMBL proteins: 
     ENSP00000373472  

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    Cloud-Clone Corp. Proteins for ADAMTS7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0009986cell surface IEA--
    GO:0031012extracellular matrix ----

    ADAMTS7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS7 
    ADAMTS family

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UKP4

    ProtoNet protein and cluster: Q9UKP4

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 8 TSP type-1 domains


    ADAMTS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS7_HUMAN, Q9UKP4
    Function: Metalloprotease that may play a role in the degradation of COMP
    Biophysicochemical properties: pH dependence: Optimum pH is between 7.5 and 9.5;
    Induction: Up-regulated in articular cartilage and synovium from arthritis patients

         Genatlas biochemistry entry for ADAMTS7:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular
    matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity TAS10464288
    GO:0008270zinc ion binding IEA--
         
    ADAMTS7 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidADAMTS7 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    ADAMTS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS7 (ATS7)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS7 / ATS7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS7 gene: 
    NM_014272.3  

    Unigene Cluster for ADAMTS7:

    ADAM metallopeptidase with thrombospondin type 1 motif, 7
    Hs.16441  [show with all ESTs]
    Unigene Representative Sequence: NM_014272
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388820(uc002bej.4 uc010und.1) ENST00000569934 ENST00000566303
    ENST00000565793(uc002bek.1) ENST00000568712
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    Additional mRNA sequence: 

    AK299844.1 AL110226.1 AL359934.1 AY327122.1 BC061631.1 

    6 DOTS entries:

    DT.447174  DT.40251220  DT.121068689  DT.121068704  DT.102843791  DT.40194653 

    24/57 AceView cDNA sequences (see all 57):

    CD625447 NM_014272 BM717519 AF140675 BM836328 AI867096 BM757906 BX451979 
    AA554881 AI001010 BF338200 BV201447 BI964683 CK903381 AA744377 AL359934 
    BX451978 AL110226 CD625449 BV201408 BM972917 BV183759 BM748960 BM718322 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGCCTG
    ADAMTS7 Expression
    About this image


    See ADAMTS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS7

    SOURCE GeneReport for Unigene cluster: Hs.16441

    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts71 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 78.38(n)1
    74.19(a)1
      9 (47.46 cM)5
    1081531  NM_001003911.21  NP_001003911.21 
     901630695 
    chicken
    (Gallus gallus)
    Aves ADAMTS71 ADAM metallopeptidase with thrombospondin type 1 motif, more 64.16(n)
    61.44(a)
      415570  XM_003641830.1  XP_003641878.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS76
    Uncharacterized protein
    59(a)
    1 ↔ 1
    GL343642.1(201400-265178)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5603641 A disintegrin and metalloproteinase with thrombospondin more 55.67(n)
    51.07(a)
      560364  XM_002662933.2  XP_002662979.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40963 metalloendopeptidase 38(a)
    (best of 2)
      5B1   --


    ENSEMBL Gene Tree for ADAMTS7 (if available)
    TreeFam Gene Tree for ADAMTS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS7 gene
    ADAMTSL42  ADAMTS132  ADAMTS122  THSD42  ADAMTSL22  PAPLN2  ADAMTSL52  ADAMTSL12  
    ENSG000002156162  ADAMTSL32  
    8 SIMAP similar genes for ADAMTS7 using alignment to 1 protein entry:     ATS7_HUMAN:
    DKFZp434H204    FLJ00317    ADAMTS12    ADAMTS6    ADAMTS10    ADAMTS16
    ADAMTS1    ADAMTS8

    ADAMTS7 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ADAMTS7
    PGOHUM00000246914 PGOHUM00000247191 PGOHUM00000247202 PGOHUM00000258987 PGOHUM00000246347


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1687 SNPs in ADAMTS7 are shown (see all 1687)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421806571,2
    C,Funtested159106138(+) TCACCG/ATCATT 2 /D syn11Minor allele frequency- A:0.00NA 4530
    rs18094241,2
    C,F,A,H--55818104(+) GCCCCC/TTCCCA 1 -- int12Minor allele frequency- T:0.33NA 6
    rs1112766761,2
    C--55819496(+) TTGGCA/GGGGGA 1 -- int10--------
    rs772584671,2
    F--55833317(-) ATGCAG/ATGCTT 1 -- int11Minor allele frequency- A:0.33NA 6
    rs777288781,2
    F--55833322(-) AACGCG/ATGCAG 1 -- int12Minor allele frequency- A:0.50NA 10
    rs1457780271,2
    C--55835822(+) GAGGG-/GGGA  
            
    GGGAG
    1 -- int10--------
    rs1995837691,2
    C--55843694(+) AGGGG-/AA/GGG
            
    ATGGC
    2 -- int1 cds10--------
    rs714488301,2
    C--55851325(+) GGGGTG/AGCTTT 1 -- int13Minor allele frequency- A:0.12NA 8
    rs1383393401,2
    C--55859454(+) CTTAT-/AACCAACA 1 -- int10--------
    rs105829101,2
    C--55860398(+) TTGAC-/CTCA  
            
    CTCAG
    1 -- int12Minor allele frequency- CTCA:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for ADAMTS7 (79051545 - 79103773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADAMTS7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749916CNV Deletion23290073
    dgv345e201CNV Deletion23290073
    esv994389CNV Deletion20482838
    esv2665394CNV Deletion23128226
    esv1505425CNV Insertion17803354
    nsv94789CNV Insertion16902084
    esv988480CNV Insertion20482838
    nsv904431CNV Loss21882294
    nsv904432CNV Loss21882294
    esv33573CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605009    OMIM disorders: --

    5 diseases for ADAMTS7:    About MalaCards
    gigantism    myocardial infarction    atherosclerosis    retinitis
    arthritis


    ADAMTS7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS7
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS7 (4 documents)

    Export disorders for ADAMTS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS7 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ADAMTS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 3, 9 Hurskainen T.L.... Apte S.S. (1999)
    2. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (2011)
    3. A genome-wide association study in Europeans and Sout h Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (2011)
    4. Identification of ADAMTS7 as a novel locus for corona ry atherosclerosis and association of ABO with myocardial infarction in the pre sence of coronary atherosclerosis: two genome-wide association studies. (PubMed id 21239051)1, 4 Reilly M.P....Rader D.J. (2011)
    5. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. (PubMed id 16585064)1, 2 Liu C.J....Di Cesare P.E. (2006)
    6. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PubMed id 19098927)1, 9 Liu C.J. (2009)
    7. Genome-wide association study of coronary and aortic c alcification implicates risk loci for coronary artery disease and myocardial inf arction. (PubMed id 23561647)1 van Setten J....de Bakker P.I. (2013)
    8. ADAMTS7 cleavage and vascular smooth muscle cell migra tion is affected by a coronary-artery-disease-associated variant. (PubMed id 23415669)1 Pu X....Ye S. (2013)
    9. Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation. (PubMed id 22247065)1 Zhang Q....Wang Y. (2012)
    10. Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. (PubMed id 20718794)1 Kumar J....Sengupta S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11173 HGNC: 223 AceView: ADAMTS7 Ensembl:ENSG00000136378 euGenes: HUgn11173
    ECgene: ADAMTS7 H-InvDB: ADAMTS7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS7 gene:
    Search GeneIP for patents involving ADAMTS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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