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ADAMTS7 Gene

protein-coding   GIFtS: 50
GCID: GC15M079051

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 71 2     ADAM-TS 72 3
COMPase1 2 3     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 72
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 71 2
     EC 3.4.24.-3
A Disintegrin And Metalloprotease With Thrombospondin Motifs-7
Preproprotein1 2
     EC 3.4.248
ADAM-TS72 3     EC 3.4.24.828
ADAMTS-72 3     

External Ids:    HGNC: 2231   Entrez Gene: 111732   Ensembl: ENSG000001363787   OMIM: 6050095   UniProtKB: Q9UKP43   

Export aliases for ADAMTS7 gene to outside databases

Previous GC identifers: GC15P074116 GC15M072142 GC15M076627 GC15M076767 GC15M076839 GC15M055809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS7 Gene:
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with
thrombospondin motifs) family. Members of this family share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal
domains. The protein encoded by this gene contains two C-terminal TS motifs. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS7 Gene:
ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7) is a protein-coding gene. Diseases associated with ADAMTS7 include gigantism, and coronary artery disease. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTSL4.

UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
Function: Metalloprotease that may play a role in the degradation of COMP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS7 gene promoter:
         AhR   Sox5   NF-1   NF-1/L   Elk-1   Sp1   MAZR   Cdc5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS7 promoter sequence
   Search Chromatin IP Primers for ADAMTS7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ADAMTS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M079051:  view genomic region     (about GC identifiers)

Start:
79,051,545 bp from pter      End:
79,103,773 bp from pter
Size:
52,229 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor  
Size: 1686 amino acids; 184095 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with COMP
Sequence caution: Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q14F51 Q6P7J9

Explore the universe of human proteins at neXtProt for ADAMTS7: NX_Q9UKP4

Explore proteomics data for ADAMTS7 at MOPED

Post-translational modifications: 

  • N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated
    proteoglycan. Contains chondroitin sulfate1
  • May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed1
  • Glycosylation2 at Asn94, Asn693, Asn778, Ser1129, Ser1131, Ser1135, Thr1214
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAMTS7 (Q9UKP4) (see all 9)
     LRPFHCQ  EEEAPEL  EDRCGVC  LTSPGPT 


    See ADAMTS7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055087.2  
    ENSEMBL proteins: 
     ENSP00000373472  
    Reactome Protein details: Q9UKP4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS7
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010909 PLAC
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry Q9UKP4

    ProtoNet protein and cluster: Q9UKP4

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 8 TSP type-1 domains


    ADAMTS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS7_HUMAN, Q9UKP4
    Function: Metalloprotease that may play a role in the degradation of COMP
    Biophysicochemical properties: pH dependence: Optimum pH is between 7.5 and 9.5;
    Induction: Up-regulated in articular cartilage and synovium from arthritis patients

         Genatlas biochemistry entry for ADAMTS7:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular
    matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IDA18485748
    GO:0005515protein binding IPI18485748
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity TAS10464288
    GO:0008270zinc ion binding IEA--
         
    ADAMTS7 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-596 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-3924 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS7 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS7_HUMAN, Q9UKP4: Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found
    associated with the external cell surface (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    endoplasmic reticulum1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0009986cell surface IEA--
    GO:0031012extracellular matrix ----

    ADAMTS7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAMTS7
        O-glycosylation of TSR domain-containing proteins



    ADAMTS7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS7
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS7

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0032331negative regulation of chondrocyte differentiation IDA--
    GO:0051603proteolysis involved in cellular protein catabolic process IMP18485748
    GO:0071347cellular response to interleukin-1 IMP18485748
    GO:0071356cellular response to tumor necrosis factor IMP18485748

    ADAMTS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS7 (ATS7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAMTS7 gene: 
    NM_014272.3  

    Unigene Cluster for ADAMTS7:

    ADAM metallopeptidase with thrombospondin type 1 motif, 7
    Hs.16441  [show with all ESTs]
    Unigene Representative Sequence: NM_014272
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388820(uc002bej.4 uc010und.1) ENST00000569934 ENST00000566303
    ENST00000565793(uc002bek.1) ENST00000568712
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ADAMTS7:
    hsa-miR-596 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-3924 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS7 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ADAMTS7

    Additional mRNA sequence: 

    AK299844.1 AL110226.1 AL359934.1 AY327122.1 BC061631.1 

    6 DOTS entries:

    DT.447174  DT.40251220  DT.121068689  DT.121068704  DT.102843791  DT.40194653 

    Selected AceView cDNA sequences (see all 57):

    BM717519 AF140675 CD625447 NM_014272 AL110226 BX451978 BV183759 CA433692 
    AA554881 BF338200 BM757906 AI001010 AL359934 AA744377 BI964683 CK903381 
    BM836328 BV201459 BC061631 BM748960 BM718322 AI867096 BM972917 BV201408 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGCCTG
    ADAMTS7 Expression
    About this image

    ADAMTS7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16441

    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts71 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 78.08(n)1
    74.07(a)1
      9 (47.46 cM)5
    1081531  NM_001003911.21  NP_001003911.21 
     901630695 
    chicken
    (Gallus gallus)
    Aves ADAMTS71 ADAM metallopeptidase with thrombospondin type 1 motif, more 64.23(n)
    61.56(a)
      415570  XM_003641830.2  XP_003641878.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS76
    ADAM metallopeptidase with thrombospondin type 1 m...
    59(a)
    1 ↔ 1
    GL343642.1(201400-265178)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts71 ADAM metallopeptidase with thrombospondin type 1 motif, more 62.63(n)
    64.08(a)
      100491770  XM_002932960.2  XP_002933006.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5603641 A disintegrin and metalloproteinase with thrombospondin more 61.59(n)
    60.23(a)
      560364  XM_002662933.3  XP_002662979.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40961 , 3 metalloendopeptidase3
    CG40961
    38(a)
    (best of 2)3
    52.89(n)1
    41.21(a)1
      5B13
    314901  NM_132019.31  NP_572247.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T19D2.13   -- 27(a)   X(3968145-3972893)   --


    ENSEMBL Gene Tree for ADAMTS7 (if available)
    TreeFam Gene Tree for ADAMTS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS7 gene
    ADAMTSL42  ADAMTS132  ADAMTS122  THSD42  ADAMTSL22  PAPLN2  ADAMTSL52  ADAMTSL12  
    ENSG000002156162  ADAMTSL32  
    8 SIMAP similar genes for ADAMTS7 using alignment to 1 protein entry:     ATS7_HUMAN:
    DKFZp434H204    FLJ00317    ADAMTS12    ADAMTS6    ADAMTS10    ADAMTS16
    ADAMTS1    ADAMTS8

    ADAMTS7 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ADAMTS7
    PGOHUM00000246914 PGOHUM00000247191 PGOHUM00000247202 PGOHUM00000258987 PGOHUM00000246347


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS7 (see all 1687)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421806571,2
    C,Funtested159106138(+) TCACCG/ATCATT 2 /D syn11Minor allele frequency- A:0.00NA 4530
    rs18094241,2
    C,F,A,H--55818104(+) GCCCCC/TTCCCA 1 -- int12Minor allele frequency- T:0.33NA 6
    rs1112766761,2
    C--55819496(+) TTGGCA/GGGGGA 1 -- int10--------
    rs772584671,2
    F--55833317(-) ATGCAG/ATGCTT 1 -- int11Minor allele frequency- A:0.33NA 6
    rs777288781,2
    F--55833322(-) AACGCG/ATGCAG 1 -- int12Minor allele frequency- A:0.50NA 10
    rs1457780271,2
    C--55835822(+) GAGGG-/GGGA  
            
    GGGAG
    1 -- int10--------
    rs1995837691,2
    C--55843694(+) AGGGG-/AA/GGG
            
    ATGGC
    2 -- int1 cds10--------
    rs714488301,2
    C--55851325(+) GGGGTG/AGCTTT 1 -- int13Minor allele frequency- A:0.12NA 8
    rs1383393401,2
    C--55859454(+) CTTAT-/AACCAACA 1 -- int10--------
    rs105829101,2
    C--55860398(+) TTGAC-/CTCA  
            
    CTCAG
    1 -- int12Minor allele frequency- CTCA:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for ADAMTS7 (79051545 - 79103773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADAMTS7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749916CNV Deletion23290073
    dgv345e201CNV Deletion23290073
    esv994389CNV Deletion20482838
    esv2665394CNV Deletion23128226
    esv1505425CNV Insertion17803354
    nsv94789CNV Insertion16902084
    esv988480CNV Insertion20482838
    nsv904431CNV Loss21882294
    nsv904432CNV Loss21882294
    esv33573CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605009    OMIM disorders: --

    6 diseases for ADAMTS7:    
    About MalaCards
    gigantism    coronary artery disease    myocardial infarction    atherosclerosis
    retinitis    arthritis


    ADAMTS7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS7
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS7 (4 documents)

    Export disorders for ADAMTS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS7 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ADAMTS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 3, 9 Hurskainen T.L.... Apte S.S. (J. Biol. Chem. 1999)
    2. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    3. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (Nat. Genet. 2011)
    4. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. (PubMed id 21239051)1, 4 Reilly M.P....Rader D.J. (Lancet 2011)
    5. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. (PubMed id 16585064)1, 2 Liu C.-J.... Di Cesare P.E. (FASEB J. 2006)
    6. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PubMed id 18485748)1, 9 Luan Y.... Liu C.-J. (Osteoarthritis Cartilage 2008)
    7. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PubMed id 19098927)1, 9 Liu C.J. (Nat Clin Pract Rheumatol 2009)
    8. Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. (PubMed id 23561647)1 van Setten J....de Bakker P.I. (Atherosclerosis 2013)
    9. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. (PubMed id 23415669)1 Pu X....Ye S. (Am. J. Hum. Genet. 2013)
    10. Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation. (PubMed id 22247065)1 Zhang Q....Wang Y. (J. Orthop. Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11173 HGNC: 223 AceView: ADAMTS7 Ensembl:ENSG00000136378 euGenes: HUgn11173
    ECgene: ADAMTS7 H-InvDB: ADAMTS7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADAMTS7 gene:
    Search GeneIP for patents involving ADAMTS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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