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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS7 Gene

protein-coding   GIFtS: 49
GCID: GC15M079051

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 5 diseases affiliated with
ADAMTS7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS7    

Aliases
for ADAMTS7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 71 2     DKFZp434H2041
ADAM-TS71 2 3     A Disintegrin And Metalloprotease With Thrombospondin Motifs-7 Preproprotein2
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 71 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 72
ADAMTS-72 3     EC 3.4.24.-3
COMPase2 3     EC 3.4.248
ADAM-TS 72 3     EC 3.4.24.828

External Ids:    HGNC: 2231   Entrez Gene: 111732   Ensembl: ENSG000001363787   OMIM: 6050095   UniProtKB: Q9UKP43   

Export aliases for ADAMTS7 gene to outside databases

Previous GC identifers: GC15P074116 GC15M072142 GC15M076627 GC15M076767 GC15M076839 GC15M055809


Summaries
for ADAMTS7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS7:
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin
motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded
by this gene contains two C-terminal TS motifs. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
Function: Metalloprotease that may play a role in the degradation of COMP




Genomic Views
for ADAMTS7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS7 gene promoter:
         AhR   Sox5   NF-1   NF-1/L   Elk-1   Sp1   MAZR   Cdc5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ADAMTS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M079051:  view genomic region     (about GC identifiers)

Start:
 79,051,545 bp from pter      End:
 79,103,773 bp from pter
Size:
 52,229 bases      Orientation:
 minus strand

Proteins
for ADAMTS7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor  
Size: 1686 amino acids; 184095 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with COMP
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found associated
with the external cell surface (By similarity)
Sequence caution: Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q14F51 Q6P7J9

Explore the universe of human proteins at neXtProt for ADAMTS7: NX_Q9UKP4

Post-translational modifications:

  • N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains
    chondroitin sulfate1
  • May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKP4

    • 4/9 DME Specific Peptides for ADAMTS7 (Q9UKP4) (see all 9)
     LRPFHCQ  EEEAPEL  EDRCGVC  LTSPGPT 

    ADAMTS7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055087.2  
    ENSEMBL proteins: 
     ENSP00000373472  

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    Uscn Proteins for ADAMTS7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0009986cell surface IEA--


    ADAMTS7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAMTS7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS7 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UKP4

    ProtoNet protein and cluster: Q9UKP4

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 8 TSP type-1 domains


    Function
    for ADAMTS7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Function: Metalloprotease that may play a role in the degradation of COMP
    Biophysicochemical properties: pH dependence: Optimum pH is between 7.5 and 9.5;
    Induction: Up-regulated in articular cartilage and synovium from arthritis patients

         Genatlas biochemistry entry for ADAMTS7:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular matrix
    protein

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822 EC 3.4.242

    miRNA
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    hsa-miR-596 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-3924 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity TAS10464288
    GO:0008270zinc ion binding IEA--


    ADAMTS7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ADAMTS7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    ADAMTS7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS7
    Search CenterWatch for drugs/clinical trials and news about ADAMTS7 / ATS7 

    Transcripts
    for ADAMTS7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS7 gene: 
    NM_014272.3  

    Unigene Cluster for ADAMTS7:

    ADAM metallopeptidase with thrombospondin type 1 motif, 7
    Hs.16441  [show with all ESTs]
    Unigene Representative Sequence: NM_014272
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388820(uc002bej.4 uc010und.1) ENST00000569934 ENST00000566303
    ENST00000565793(uc002bek.1) ENST00000568712

    miRNA
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    hsa-miR-596 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-3924 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS7 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK299844.1 AL110226.1 AL359934.1 AY327122.1 BC061631.1 

    6 DOTS entries:

    DT.447174  DT.40251220  DT.121068689  DT.121068704  DT.102843791  DT.40194653 

    24/57 AceView cDNA sequences (see all 57):

    BM717519 AF140675 NM_014272 CD625447 BC061631 AL359934 AI001010 CA433692 
    BM757906 AL110226 AA554881 BV201408 BV201447 CD625449 BX451979 BM972917 
    AI867096 BM718322 BM836328 BM748960 BV201459 CK903381 BX451978 BV183759 

    GeneLoc Exon Structure


    Expression
    for ADAMTS7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGAGCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTS7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADAMTS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS7

    SOURCE GeneReport for Unigene cluster: Hs.16441

    UniProtKB/Swiss-Prot: ATS7_HUMAN, Q9UKP4
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in
    meniscus, bone, tendon, cartilage, synovium, fat and ligaments

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    In Situ
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    Orthologs
    for ADAMTS7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS7 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS71 ADAM metallopeptidase with thrombospondin type 1 motif, more 64.16(n)
    61.44(a)    		   415570  XM_003641830.1  XP_003641878.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAMTS76
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL343642.1(201400-260464)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5603641 A disintegrin and metalloproteinase with thrombospondin more 55.67(n)
    51.07(a)    		   560364  XM_002662933.2  XP_002662979.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG40963 metalloendopeptidase 38(a)
    (best of 2)    		   5B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T19D2.13   -- 27(a)   X(3968145-3972893)   --


    ENSEMBL Gene Tree for ADAMTS7 (if available)
    TreeFam Gene Tree for ADAMTS7 (if available) 

    Paralogs
    for ADAMTS7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS7 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS122  ADAMTS142  ADAMTS22  
    ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS152  ADAMTS162  ADAMTS82  ADAMTS92  ADAMTS32  
    ADAMTS102  
    9 SIMAP similar genes for ADAMTS7 using alignment to 1 protein entry:     ATS7_HUMAN:
    DKFZp434H204    FLJ00317    ADAMTS12    ADAMTS6    ADAMTS10    ADAMTS16
    ADAMTS1    ADAMTS8    ADAMTS4

    ADAMTS7 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ADAMTS7
    PGOHUM00000246914 PGOHUM00000247191 PGOHUM00000247202 PGOHUM00000258987 PGOHUM00000246347


    Genomic Variants
    for ADAMTS7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1320 NCBI SNPs in ADAMTS7 are shown (see all 1320)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1421806571,2
    		C,Fother55826039(+) TCACCG/ATCATT 2 /D syn11Minor allele frequency- A:0.00NA 4530
    rs1123912361,2
    		--55809474(+) GAAGAG/ATCAAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs74971621,2
    		C--55809556(+) GCAAGT/CGACAT 1 -- int12Minor allele frequency- C:0.00NA 4
    rs10451401,2
    		--55810041(-) GGGGAC/GCTCCT 1 -- ut31 ese3 trp31Minor allele frequency- G:0.00NA 2
    rs10451391,2
    		--55810054(-) CCAGCG/AGCAGG 1 -- ut31 ese33Minor allele frequency- A:0.15MN NA 188
    rs1127250951,2
    		C,--55810063(+) GGGTAG/ATGAGA 1 -- ut312Minor allele frequency- A:0.21CSA WA 120
    rs10451351,2
    		--55810091(-) CCCCTA/GCGCCC 1 -- ut31 ese32Minor allele frequency- G:0.28MN NA 186
    rs1122386471,2
    		C,--55810107(+) AGCTCC/TGCCAC 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs10451271,2
    		--55810176(-) GGGTTG/ACCCGC 2 /T /A mis1 ese31Minor allele frequency- A:0.00NA 2
    rs10451261,2
    		--55810177(-) CGGGTT/CGCCCG 2 /V syn11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for ADAMTS7 (79051545 - 79103773 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ADAMTS7
         1 CNV: 7073

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    Disorders / Diseases
    for ADAMTS7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS7 for disorders           About GeneDecksing

    OMIM gene information: 605009    OMIM disorders: --

    5 diseases for ADAMTS7:    About MalaCards
    myocardial infarction    gigantism    atherosclerosis    retinitis
    arthritis

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS7 (4 documents)

    Export disorders for ADAMTS7 gene to outside databases

    Publications
    for ADAMTS7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS7 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ADAMTS7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 3, 9 Hurskainen T.L.... Apte S.S. (1999)
    2. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. (PubMed id 16585064)1, 2 Liu C.J....Di Cesare P.E. (2006)
    3. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PubMed id 19098927)1, 9 Liu C.J. (2009)
    4. Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation. (PubMed id 22247065)1 Zhang Q....Wang Y. (2012)
    5. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1 Schunkert H....Samani N.J. (2011)
    6. Identification of ADAMTS7 as a novel locus for corona ry atherosclerosis and association of ABO with myocardial infarction in the pre sence of coronary atherosclerosis: two genome-wide association studies. (PubMed id 21239051)1 Reilly M.P....Rader D.J. (2011)
    7. A genome-wide association study in Europeans and Sout h Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1 (2011)
    8. Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS. (PubMed id 20718794)1 Kumar J....Sengupta S. (2010)
    9. ADAMTS-7, a direct target of PTHrP, adversely regulat es endochondral bone growth by associating with and inactivating GEP growth fac tor. (PubMed id 19487464)1 Bai X.H....Liu C.J. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for ADAMTS7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ADAMTS7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11173 HGNC: 223 AceView: ADAMTS7 Ensembl:ENSG00000136378 euGenes: HUgn11173
    ECgene: ADAMTS7 H-InvDB: ADAMTS7

    Other Databases showing ADAMTS7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMTS7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAMTS7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS7 gene:
    Search GeneIP for patents involving ADAMTS7

    GeneCards and IP:
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