Aliases for ADAMTS7 Gene
External Ids for ADAMTS7 Gene
Previous GeneCards Identifiers for ADAMTS7 Gene
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS7 Gene
ADAMTS7 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7) is a Protein Coding gene. Diseases associated with ADAMTS7 include Artery Disease and Coronary Artery Disease. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS12.
UniProtKB/Swiss-Prot for ADAMTS7 Gene
Metalloprotease that may play a role in the degradation of COMP.