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Aliases for ADAMTS6 Gene

Aliases for ADAMTS6 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 6 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 6 2 3
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6 2 3
  • ADAM-TS 6 3 4
  • ADAM-TS6 3 4
  • ADAMTS-6 3 4
  • EC 3.4.24.82 63
  • EC 3.4.24.- 4

External Ids for ADAMTS6 Gene

Summaries for ADAMTS6 Gene

Entrez Gene Summary for ADAMTS6 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS6 Gene

ADAMTS6 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 6) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS6 Gene

Genomics for ADAMTS6 Gene

Genomic Location for ADAMTS6 Gene

Start:
65,148,736 bp from pter
End:
65,481,920 bp from pter
Size:
333,185 bases
Orientation:
Minus strand

Genomic View for ADAMTS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS6 Gene

Regulatory Elements for ADAMTS6 Gene

Proteins for ADAMTS6 Gene

  • Protein details for ADAMTS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKP5-ATS6_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 6
    Protein Accession:
    Q9UKP5
    Secondary Accessions:
    • Q59EX6
    • Q5IR87
    • Q5IR88
    • Q5IR89
    • Q68DL1

    Protein attributes for ADAMTS6 Gene

    Size:
    1117 amino acids
    Molecular mass:
    125273 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS6 Gene

Proteomics data for ADAMTS6 Gene at MOPED

Selected DME Specific Peptides for ADAMTS6 Gene

Post-translational modifications for ADAMTS6 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn99, Asn172, Asn222, Asn234, Asn724, and Asn956

Other Protein References for ADAMTS6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADAMTS6 Gene

Gene Families for ADAMTS6 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

Suggested Antigen Peptide Sequences for ADAMTS6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKP5

UniProtKB/Swiss-Prot:

ATS6_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix:
    • Q9UKP5
  • Contains 1 disintegrin domain.:
    • Q9UKP5
  • Contains 1 peptidase M12B domain.:
    • Q9UKP5
  • Contains 1 PLAC domain.:
    • Q9UKP5
  • Contains 5 TSP type-1 domains.:
    • Q9UKP5
genes like me logo Genes that share domains with ADAMTS6: view

Function for ADAMTS6 Gene

Molecular function for ADAMTS6 Gene

GENATLAS Biochemistry: a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 6,expressed in the periimplantation period in mouse embryo and adult tissues,extracellular matrix protein
UniProtKB/Swiss-Prot Induction: Isoform 1 and isoform 2 expressions are up-regulated by TNF in retinal pigment epithelial cells.

Enzyme Numbers (IUBMB) for ADAMTS6 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008237 metallopeptidase activity TAS 10464288
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS6: view

Phenotypes for ADAMTS6 Gene

genes like me logo Genes that share phenotypes with ADAMTS6: view

miRNA for ADAMTS6 Gene

miRTarBase miRNAs that target ADAMTS6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAMTS6 Gene

Localization for ADAMTS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS6 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS6 Gene COMPARTMENTS Subcellular localization image for ADAMTS6 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS6: view

Pathways for ADAMTS6 Gene

SuperPathways for ADAMTS6 Gene

No Data Available

Interacting Proteins for ADAMTS6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370443%0d%0a9606.ENSP00000356480%0d%0a
Selected Interacting proteins: ENSP00000370443 Q9UKP5-ATS6_HUMAN for ADAMTS6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ADAMTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS6: view

No data available for Pathways by source for ADAMTS6 Gene

Transcripts for ADAMTS6 Gene

Unigene Clusters for ADAMTS6 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS6 Gene

No ASD Table

Relevant External Links for ADAMTS6 Gene

GeneLoc Exon Structure for
ADAMTS6
ECgene alternative splicing isoforms for
ADAMTS6

Expression for ADAMTS6 Gene

mRNA expression in normal human tissues for ADAMTS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS6 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS6 Gene Hs.482291

mRNA Expression by UniProt/SwissProt for ADAMTS6 Gene

Q9UKP5-ATS6_HUMAN
Tissue specificity: Expressed at low levels in placenta and barely detectable in a number of other tissues
genes like me logo Genes that share expressions with ADAMTS6: view

No data available for mRNA differential expression in normal tissues for ADAMTS6 Gene

Orthologs for ADAMTS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS6 35
  • 99.7 (n)
  • 99.91 (a)
ADAMTS6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS6 35
  • 95.88 (n)
  • 98.12 (a)
ADAMTS6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS6 35
  • 95.88 (n)
  • 98.48 (a)
ADAMTS6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts6 35
  • 92.84 (n)
  • 95.97 (a)
Adamts6 16
Adamts6 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS6 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS6 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts6 35
  • 92.18 (n)
  • 95.79 (a)
chicken
(Gallus gallus)
Aves ADAMTS6 35
  • 87.44 (n)
  • 92.66 (a)
ADAMTS6 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts6 35
  • 81.56 (n)
  • 89.62 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts6 35
  • 75.21 (n)
  • 83.27 (a)
adamts6 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14869 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gon-1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ADAMTS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS6 Gene

ENSEMBL:
Gene Tree for ADAMTS6 (if available)
TreeFam:
Gene Tree for ADAMTS6 (if available)

Paralogs for ADAMTS6 Gene

Selected SIMAP similar genes for ADAMTS6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS6: view

Variants for ADAMTS6 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs33392 -- 65,461,042(-) TGGGC(A/C)AGTCC intron-variant
rs33393 -- 65,480,984(-) TGTGT(A/G)TTTTA intron-variant
rs33394 -- 65,483,117(-) AAACT(C/T)TTAAA upstream-variant-2KB
rs33395 -- 65,483,186(-) GAAAT(C/T)GACTT upstream-variant-2KB
rs33396 -- 65,472,850(-) TATGT(A/G)TCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS6 Gene

Variant ID Type Subtype PubMed ID
dgv6083n71 CNV Gain 21882294
dgv6084n71 CNV Gain 21882294
nsv4863 CNV Insertion 18451855
nsv512852 CNV Insertion 21212237
nsv830325 CNV Gain 17160897
esv2730275 CNV Deletion 23290073
esv8314 CNV Gain 19470904
esv26770 CNV Loss 19812545
esv2672410 CNV Deletion 23128226
esv2730276 CNV Deletion 23290073

Relevant External Links for ADAMTS6 Gene

HapMap Linkage Disequilibrium report
ADAMTS6
Human Gene Mutation Database (HGMD)
ADAMTS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS6 Gene

Disorders for ADAMTS6 Gene

Relevant External Links for ADAMTS6

Genetic Association Database (GAD)
ADAMTS6
Human Genome Epidemiology (HuGE) Navigator
ADAMTS6
genes like me logo Genes that share disorders with ADAMTS6: view

No data available for UniProtKB/Swiss-Prot for ADAMTS6 Gene

Publications for ADAMTS6 Gene

  1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PMID: 10464288) Hurskainen T.L. … Apte S.S. (J. Biol. Chem. 1999) 2 3 4 23
  2. Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control. (PMID: 16129570) Bevitt D.J. … McKie N. (Gene 2005) 3 4 23
  3. Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. (PMID: 12697333) Bevitt D.J. … McKie N. (Biochim. Biophys. Acta 2003) 4 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3

Products for ADAMTS6 Gene

Sources for ADAMTS6 Gene

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