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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS6 Gene

protein-coding   GIFtS: 52
GCID: GC05M064526

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 61 2     ADAMTS-62 3
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 61 2
     ADAM-TS 62 3
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 61 2     EC 3.4.24.-3
ADAM-TS62 3     EC 3.4.24.828

External Ids:    HGNC: 2221   Entrez Gene: 111742   Ensembl: ENSG000000491927   OMIM: 6050085   UniProtKB: Q9UKP53   

Export aliases for ADAMTS6 gene to outside databases

Previous GC identifers: GC05M064657 GC05M066048 GC05M064480 GC05M064545 GC05M061399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS6 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS6 Gene: 
ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif, 6) is a protein-coding gene. Diseases associated with ADAMTS6 include retinitis. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS6 gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   E47   IRF-2   IRF-7A   Sox9   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAMTS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q13

ADAMTS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064526:  view genomic region     (about GC identifiers)

Start:
64,444,563 bp from pter      End:
64,777,747 bp from pter
Size:
333,185 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor  
Size: 1117 amino acids; 125273 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q59EX6 Q5IR87 Q5IR88 Q5IR89 Q68DL1
Alternative splicing: 4 isoforms:  Q9UKP5-1   Q9UKP5-2   Q9UKP5-3   Q9UKP5-4   (Contains critical point mutations in the region encoding the catalytic domain as well as 2 point mutations compared with genomic sequence. May either be a rare polymorphism or may have arisen through a combination of aberrant RNA editing and point mutation/sequencing error)

Explore the universe of human proteins at neXtProt for ADAMTS6: NX_Q9UKP5

Explore proteomics data for ADAMTS6 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKP5

  • 2 DME Specific Peptides for ADAMTS6 (Q9UKP5)
     VETLVVAD  CSRTCGGGV 

    ADAMTS6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS6 Protein Expression
    REFSEQ proteins: NP_922932.2  
    ENSEMBL proteins: 
     ENSP00000370443   ENSP00000424377   ENSP00000423551   ENSP00000440995  

    Human Recombinant Protein Products for ADAMTS6: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTS6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS6 
    ADAMTS family

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UKP5

    ProtoNet protein and cluster: Q9UKP5

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 5 TSP type-1 domains


    ADAMTS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS6_HUMAN, Q9UKP5
    Induction: Isoform 1 and isoform 2 expressions are up-regulated by TNF in retinal pigment epithelial cells

         Genatlas biochemistry entry for ADAMTS6:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 6,expressed in
    the periimplantation period in mouse embryo and adult tissues,extracellular matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity TAS10464288
    GO:0008270zinc ion binding IEA--
         
    ADAMTS6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTS6:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS6 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS6 
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    SwitchGear 3'UTR luciferase reporter plasmidADAMTS6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS6

    1 Interacting protein for ADAMTS6 (Q9UKP53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    ADAMTS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS6 (ATS6)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS6 / ATS6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS6 gene: 
    NM_197941.2  

    Unigene Cluster for ADAMTS6:

    ADAM metallopeptidase with thrombospondin type 1 motif, 6
    Hs.482291  [show with all ESTs]
    Unigene Representative Sequence: NM_197941
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381055(uc003jtp.3 uc003jtq.3) ENST00000381052(uc003jto.3 uc003jtr.1)
    ENST00000314351 ENST00000417396 ENST00000470597 ENST00000464680 ENST00000504282
    ENST00000502886 ENST00000536360
    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS6 (see all 51):
    hsa-miR-124* hsa-miR-4317 hsa-miR-140-5p hsa-miR-3152-3p hsa-miR-513a-5p hsa-miR-1258 hsa-miR-29a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF140674.1 AK131039.1 AY692422.1 AY692423.1 AY692424.1 AY692426.1 BC010563.1 BC071654.1 
    CR749356.1 

    6 DOTS entries:

    DT.40265233  DT.97833556  DT.120805096  DT.120805079  DT.120805089  DT.91731890 

    24/183 AceView cDNA sequences (see all 183):

    CR596611 AI080760 AA552978 AV714932 CR749356 AI089562 AA832416 BQ686292 
    AL597701 CR593673 AW663364 AW263644 AA854015 AI608865 AI312843 NM_197941 
    BM970571 AW302499 AW131227 BC071654 BX459174 AI697838 BX484449 BC010563 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS6 expression in normal human tissues (normalized intensities)      ADAMTS6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCTAACA
    ADAMTS6 Expression
    About this image


    ADAMTS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Endothelium (Cardiovascular System)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...

    See ADAMTS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS6

    SOURCE GeneReport for Unigene cluster: Hs.482291

    UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5
    Tissue specificity: Expressed at low levels in placenta and barely detectable in a number of other tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS6 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts61 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 92.84(n)1
    95.97(a)1
      13 (56.42 cM)5
    1081541  NM_001081020.11  NP_001074489.11 
     1042878735 
    chicken
    (Gallus gallus)
    Aves ADAMTS61 ADAM metallopeptidase with thrombospondin type 1 motif, more 87.44(n)
    92.66(a)
      427160  XM_424749.3  XP_424749.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    90(a)
    85(a)
    1 ↔ many
    1 ↔ many
    2(10454625-10484852)
    2(10517409-10628193)
    zebrafish
    (Danio rerio)
    Actinopterygii adamts61 ADAM metallopeptidase with thrombospondin type 1 motif, more 75.27(n)
    83.27(a)
      569099  XM_001923169.1  XP_001923204.1 


    ENSEMBL Gene Tree for ADAMTS6 (if available)
    TreeFam Gene Tree for ADAMTS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS6 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS142  ADAMTS22  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    14 SIMAP similar genes for ADAMTS6 using alignment to 3 protein entries:     ATS6_HUMAN (see all proteins):
    ADAMTS10    ADAMTS7    ADAMTS18    ADAMTS4    ADAMTS16    ADAMTS20
    ADAMTS9    ADAMTS1    ADAMTSL5    DKFZp686E01144    ADAMTS8    ADAMTS12
    ADAMTS15    ADAMTS5

    ADAMTS6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5965 SNPs in ADAMTS6 are shown (see all 5965)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679424321,2
    C--64377707(-) TGCAA-/GTGT  
     
    /GTGTGT
    GTGTG
    2 -- int1 cds12NA 4
    rs47000761,2
    C,A,H--64444070(+) TTAGCC/TGGGCG 1 -- ds50015Minor allele frequency- T:0.10NA WA 10
    rs615247591,2
    C--64444232(+) AAAAA-/AA/AAA
            
    GGAAA
    2 -- ds5001 cds12NA 4
    rs763903041,2
    C--64444362(+) TACCTC/GACACT 1 -- ds50010--------
    rs786525031,2
    C--64444363(+) ACCTGA/TCACTC 1 -- ds50010--------
    rs168934341,2
    C,F--64444427(+) GTAATA/CAGGAT 1 -- ds50014Minor allele frequency- C:0.06NA WA 260
    rs1433971481,2
    --64444509(+) TCATTA/CCTGGT 1 -- ds50010--------
    rs1386163781,2
    C--64444832(+) ATTTCA/G/TTTCTG 2 -- ut310--------
    rs168934351,2
    C,F,H--64444922(+) TCTCAC/TGGGGT 1 -- ut31 ese321Minor allele frequency- T:0.06NA NS EA 2118
    rs1164267861,2
    --64445022(+) CCTGGA/GGTTCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAMTS6 (64444563 - 64694563 bp, first 250kb of ADAMTS6)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADAMTS6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730275CNV Deletion23290073
    esv2730276CNV Deletion23290073
    esv2672410CNV Deletion23128226
    nsv4863CNV Insertion18451855
    nsv512852CNV Insertion21212237
    esv26770CNV Loss19812545
    dgv6083n71CNV Gain21882294
    esv8314CNV Gain19470904
    dgv6084n71CNV Gain21882294
    nsv830325CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605008    OMIM disorders: --

    2 diseases for ADAMTS6:    About MalaCards
    retinitis    


    ADAMTS6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS6
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS6 (1 document)

    Export disorders for ADAMTS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS6 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ADAMTS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 3, 9 Hurskainen T.L.... Apte S.S. (1999)
    2. Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control. (PubMed id 16129570)1, 2, 9 Bevitt D.J.... McKie N. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. (PubMed id 12697333)2, 9 Bevitt D.J....McKie N. (2003)
    5. Genome-wide association analyses identify multiple loc i associated with central corneal thickness and keratoconus. (PubMed id 23291589)1 Lu Y....Wong T.Y. (2013)
    6. Genome-wide association study of clinical dimensions o f schizophrenia: polygenic effect on disorganized symptoms. (PubMed id 23212062)1 Fanous A.H....Levinson D.F. (2012)
    7. A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)1 Wang K.S....Aragam N. (2010)
    8. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. (PubMed id 18579725)1 Sakai N....Sakurada K. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PubMed id 15123239)1 Boisguerin P....Volkmer-Engert R. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11174 HGNC: 222 AceView: ADAMTS6andFKSG14andLOC345667 Ensembl:ENSG00000049192 euGenes: HUgn11174
    ECgene: ADAMTS6 H-InvDB: ADAMTS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS6 gene:
    Search GeneIP for patents involving ADAMTS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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