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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS6 Gene

protein-coding   GIFtS: 50
GCID: GC05M064526

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 1 disease affiliated with
ADAMTS6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS6    

Aliases
for ADAMTS6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 61 2     ADAM-TS 62 3
ADAM-TS61 2 3     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 62
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 61 2
     EC 3.4.24.-3
ADAMTS-62 3     EC 3.4.24.828

External Ids:    HGNC: 2221   Entrez Gene: 111742   Ensembl: ENSG000000491927   OMIM: 6050085   UniProtKB: Q9UKP53   

Export aliases for ADAMTS6 gene to outside databases

Previous GC identifers: GC05M064657 GC05M066048 GC05M064480 GC05M064545 GC05M061399


Summaries
for ADAMTS6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS6:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. (provided by
RefSeq, Jul 2008)




Genomic Views
for ADAMTS6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS6 gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   E47   IRF-2   IRF-7A   Sox9   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAMTS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q13

ADAMTS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064526:  view genomic region     (about GC identifiers)

Start:
 64,444,563 bp from pter      End:
 64,777,747 bp from pter
Size:
 333,185 bases      Orientation:
 minus strand

Proteins
for ADAMTS6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor  
Size: 1117 amino acids; 125273 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q59EX6 Q5IR87 Q5IR88 Q5IR89 Q68DL1
Alternative splicing: 4 isoforms:  Q9UKP5-1   Q9UKP5-2   Q9UKP5-3   Q9UKP5-4   (Contains critical point mutations in the region encoding the catalytic domain as well as 2 point mutations compared with genomic sequence. May either be a rare polymorphism or may have arisen through a combination of aberrant RNA editing and point mutation/sequencing error)

Explore the universe of human proteins at neXtProt for ADAMTS6: NX_Q9UKP5

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKP5

    • 2 DME Specific Peptides for ADAMTS6 (Q9UKP5)
     VETLVVAD  CSRTCGGGV 

    ADAMTS6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_922932.2  
    ENSEMBL proteins: 
     ENSP00000370443   ENSP00000424377   ENSP00000423551   ENSP00000440995  

    Human Recombinant Protein Products: 
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    Novus Biologicals ADAMTS6 Protein
    Novus Biologicals ADAMTS6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAMTS6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--


    ADAMTS6 for ontologies           About GeneDecksing



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    Uscn Antibodies for ADAMTS6
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    Assay Products for ADAMTS6: 
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    Uscn ELISAs and CLIAs for ADAMTS6

    Protein Domains /
    Families
    for ADAMTS6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS6 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UKP5

    ProtoNet protein and cluster: Q9UKP5

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 5 TSP type-1 domains


    Function
    for ADAMTS6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5
    Induction: Isoform 1 and isoform 2 expressions are up-regulated by TNF in retinal pigment epithelial cells

         Genatlas biochemistry entry for ADAMTS6:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 6,expressed in the
    periimplantation period in mouse embryo and adult tissues,extracellular matrix protein

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS6
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS6 (see all 51):
    hsa-miR-124* hsa-miR-4317 hsa-miR-140-5p hsa-miR-3152-3p hsa-miR-513a-5p hsa-miR-1258 hsa-miR-29a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS6 (see all 7)
    OriGene shRNA RFP: ADAMTS6
    OriGene siRNA: ADAMTS6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADAMTS6

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS6 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADAMTS6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS6

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity TAS10464288
    GO:0008270zinc ion binding IEA--


    ADAMTS6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADAMTS6:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for ADAMTS6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS6

    1 Interacting protein for ADAMTS6 (Q9UKP53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    ADAMTS6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS6
    Search CenterWatch for drugs/clinical trials and news about ADAMTS6 / ATS6 

    Transcripts
    for ADAMTS6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS6 gene: 
    NM_197941.2  

    Unigene Cluster for ADAMTS6:

    ADAM metallopeptidase with thrombospondin type 1 motif, 6
    Hs.482291  [show with all ESTs]
    Unigene Representative Sequence: NM_197941
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381055(uc003jtp.3 uc003jtq.3) ENST00000381052(uc003jto.3 uc003jtr.1)
    ENST00000314351 ENST00000417396 ENST00000470597 ENST00000464680 ENST00000504282
    ENST00000502886 ENST00000536360

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ADAMTS6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS6
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS6 (see all 51):
    hsa-miR-124* hsa-miR-4317 hsa-miR-140-5p hsa-miR-3152-3p hsa-miR-513a-5p hsa-miR-1258 hsa-miR-29a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS6 (see all 7)
    OriGene shRNA RFP: ADAMTS6
    OriGene siRNA: ADAMTS6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS6
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS6
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    GenScript: all cDNA clones in your preferred vector: ADAMTS6 (NM_197941)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS6 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS6

    Additional cDNA sequence: 

    AF140674.1 AK131039.1 AY692422.1 AY692423.1 AY692424.1 AY692426.1 BC010563.1 BC071654.1 
    CR749356.1 

    6 DOTS entries:

    DT.40265233  DT.97833556  DT.120805096  DT.120805079  DT.120805089  DT.91731890 

    24/183 AceView cDNA sequences (see all 183):

    CR596611 NM_197941 CF528606 AA905058 BQ013157 BC008504 BC010563 AW131227 
    AA832416 AI436670 AW297206 CR593673 BM671548 BM970571 AI080760 AL597701 
    AI312843 BX484449 AI608865 AA809982 AI819500 AA552978 AV714932 BX459174 

    GeneLoc Exon Structure


    Expression
    for ADAMTS6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCTAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTS6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See ADAMTS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS6

    SOURCE GeneReport for Unigene cluster: Hs.482291

    UniProtKB/Swiss-Prot: ATS6_HUMAN, Q9UKP5
    Tissue specificity: Expressed at low levels in placenta and barely detectable in a number of other tissues

        SABiosciences Custom PCR Arrays for ADAMTS6
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    In Situ
    Assay Products:     
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    Orthologs
    for ADAMTS6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS6 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS61 ADAM metallopeptidase with thrombospondin type 1 motif, more 87.44(n)
    92.66(a)    		   427160  XM_424749.3  XP_424749.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii adamts61 ADAM metallopeptidase with thrombospondin type 1 motif, more 75.27(n)
    83.27(a)    		   569099  XM_001923169.1  XP_001923204.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ppn6
    		 Papilin
    		 8(a)
    		 possible ortholog
    		 3R(24346387-24366053)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-66
    		 Papilin
    		 9(a)
    		 possible ortholog
    		 V(7827213-7842365)


    ENSEMBL Gene Tree for ADAMTS6 (if available)
    TreeFam Gene Tree for ADAMTS6 (if available) 

    Paralogs
    for ADAMTS6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS6 gene
    ADAMTS72  ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS122  ADAMTS142  ADAMTS22  
    ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS152  ADAMTS162  ADAMTS92  ADAMTS82  ADAMTS32  
    ADAMTS102  
    16 SIMAP similar genes for ADAMTS6 using alignment to 3 protein entries:     ATS6_HUMAN (see all proteins):
    ADAMTS10    ADAMTS7    ADAMTS18    ADAMTS4    ADAMTS16    ADAMTS20
    ADAMTS9    ADAMTS1    ADAMTSL5    DKFZp686E01144    ADAMTS8    ADAMTS12
    ADAMTS15    ADAMTS5    ADAMTS3    THSD4

    ADAMTS6 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5202 NCBI SNPs in ADAMTS6 are shown (see all 5202)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs100778341,2
    		C,--61571666(+) agggaA/Gggaag 1 -- int1 trp30--------
    rs47000761,2
    		C,A,H,--64444070(+) TTAGCC/TGGGCG 1 -- ds50015Minor allele frequency- T:0.10NA WA 10
    rs763903041,2
    		C--64444362(+) TACCTC/GACACT 1 -- ds50010--------
    rs786525031,2
    		C--64444363(+) ACCTGA/TCACTC 1 -- ds50010--------
    rs168934341,2
    		C,F,--64444427(+) GTAATA/CAGGAT 1 -- ds50014Minor allele frequency- C:0.06NA WA 260
    rs1433971481,2
    		--64444509(+) TCATTA/CCTGGT 1 -- ds50010--------
    rs1386163781,2
    		--64444832(+) ATTTCA/GTTCTG 1 -- ut310--------
    rs168934351,2
    		C,F,H,--64444922(+) TCTCAC/TGGGGT 1 -- ut31 ese321Minor allele frequency- T:0.06NA NS EA 2118
    rs1164267861,2
    		--64445022(+) CCTGGA/GGTTCC 1 -- ut310--------
    rs1894265061,2
    		--64445119(+) AATAGC/GGCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAMTS6 (64444563 - 64694563 bp, first 250kb of ADAMTS6)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ADAMTS6
         1 CNV: 39420
         2 Indels: 60534 64222

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    Disorders / Diseases
    for ADAMTS6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS6 for disorders           About GeneDecksing

    OMIM gene information: 605008    OMIM disorders: --

    1 disease for ADAMTS6:    About MalaCards
    retinitis

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS6 (1 document)

    Export disorders for ADAMTS6 gene to outside databases

    Publications
    for ADAMTS6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS6 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ADAMTS6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 3, 9 Hurskainen T.L.... Apte S.S. (1999)
    2. Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control. (PubMed id 16129570)1, 2, 9 Bevitt D.J.... McKie N. (2005)
    3. Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. (PubMed id 12697333)2, 9 Bevitt D.J....McKie N. (2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)1 Wang K.S....Aragam N. (2010)
    6. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. (PubMed id 18579725)1 Sakai N....Sakurada K. (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. ADAMTS: a novel family of extracellular matrix proteases. (PubMed id 11167130)1 Tang B.L. (2001)

    External Searches for ADAMTS6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ADAMTS6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11174 HGNC: 222 AceView: ADAMTS6andFKSG14andLOC345667 Ensembl:ENSG00000049192 euGenes: HUgn11174
    ECgene: ADAMTS6 H-InvDB: ADAMTS6

    Other Databases showing ADAMTS6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMTS6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAMTS6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS6 gene:
    Search GeneIP for patents involving ADAMTS6

    GeneCards and IP:
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