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ADAMTS5 Gene

protein-coding GIFtS: 59

GC21M027215

ADAM metallopeptidase with thrombospondin type 1 motif, 5
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
ADAM-TS5 ^³
ADAMTS-11 ^³
ADAMTS-5 ^³
ADAMTS11 ^¹, ², ³, ⁵
ADMP-2 ^¹, ², ³
ADMP2 ^³
Aggrecanase-2 ^³
EC 3.4.24.- ^³
FLJ36738 ^²
aggrecanase-2 ^²

Descriptions
A disintegrin and metalloproteinase with thrombospondin motifs 11 ^³
ADAM metallopeptidase with thrombospondin type 1 motif, 5 ^²
ADAM-TS 11 ^³
ADAM-TS 5 ^³
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) ^¹, ²
disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5 ⁹

External Ids
HGNC: 221¹
Entrez Gene: 11096²
UniProtKB: Q9UNA0³
Ensembl: ENSG00000154736⁷

Search outside databases for aliases for ADAMTS5 gene

Previous GC identifers: GC21M024872 GC21M027200

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAMTS5:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin

motifs) protein family. Members of the family share several distinct protein modules, including a

propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin

type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,

and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal

TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play

an important role in the destruction of aggrecan in arthritic diseases. May play a role in

proteolytic processing mostly during the peri-implantation period

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band: 21q21.3

ADAMTS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M027215:	GeneLoc	Nature:405,311-319
Start:	27,212,112 bp from pter	13,871,628 bp from centromere
End:	27,260,703 bp from pter	13,916,697 bp from centromere
Size:	48,592 bases	45,070 bases
Orientation:	minus strand	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	NM_007038
genomic clones:	KB45E1 KB1346F10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor

Size: 930 amino acids; 101716 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

PDB structure from and Proteopedia :

2RJQ (3D)

3B8Z (3D)

Secondary accessions: Q52LV4 Q9UKP2

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

REFSEQ proteins: NP_008969.2

ENSEMBL proteins:

ENSP00000284987

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADAMTS5 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAMTS5
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAMTS5)
	Human Recombinant Proteins from Abnova (ADAMTS5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	TAS	10438522
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348

About this table

Antibodies for ADAMTS5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS5
	Sigma-Aldrich Antibodies for ADAMTS5
	R&D Systems Antibodies for ADAMTS5
	Antibodies from Abcam (ADAMTS5), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ADAMTS5

Assays for ADAMTS5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UNA0

ProtoNet protein and cluster: Q9UNA0

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the

extracellular matrix

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 2 TSP type-1 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAMTS5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAMTS5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007038

Applied Biosystems Silencer® siRNAs for ADAMTS5

Sigma-Aldrich siRNA and siRNA Panels for ADAMTS5

Sigma-Aldrich shRNA Panels and shRNA for ADAMTS5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007038
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007038
untagged cDNA clone in CMV expression vector: NM_007038

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007038

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play

an important role in the destruction of aggrecan in arthritic diseases. May play a role in

proteolytic processing mostly during the peri-implantation period

Catalytic activity: Cleaves aggrecan at the 392-Glu- -Ala-393 site

Enzyme Number (IUBMB): EC 3.4.24.-

Genatlas biochemistry entry for ADAMTS5:

a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin

type 1 motif 5,highly expressed in the peri-implantation period in mouse embryo and trophoblast

and in adult tissues,extracellular matrix protein

4 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Adamts5):

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	TAS	10438522
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ADAMTS5

5/15 Interacting proteins for ADAMTS5 (ENSP00000284987³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACAN	ENSP00000268134³	STRING (score=.939)
MMP13	ENSP00000339672³	STRING (score=.917)
FURIN	ENSP00000268171³	STRING (score=.859)
LGALS3	ENSP00000254301³	STRING (score=.854)
IL18	ENSP00000280357³	STRING (score=.845)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	10438522

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAMTS5

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAMTS5
2 Novoseek chemical compound relationships for ADAMTS5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	62.88	6	16507336 (2), 11817583 (1), 17763444 (1)
zinc	12.41	3	10464288 (2), 18799682 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAMTS5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAMTS5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007038

Sigma-Aldrich siRNA and siRNA Panels for ADAMTS5

Sigma-Aldrich shRNA Panels and shRNA for ADAMTS5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007038

REFSEQ mRNAs for ADAMTS5 gene:

NM_007038.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007038

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007038
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007038
                                 untagged cDNA clone in CMV expression vector: NM_007038

Additional cDNA sequence:

AF086299.1 AF086358.1 AF141293.1 AF142099.1 AK094057.1 AK095905.1 BC093775.1 BC093777.1

4 DOTS entries:

DT.205954 DT.102571 DT.121130367 DT.100675235

24/81 AceView cDNA sequences (see all 81 ):

H88919 AI269148 BQ184915 BX498507 BM127085 H89140 BE856159 AA425042

BM932138 CD515844 AW612318 AI273671 AL598390 BF060767 AF141293 AI375941

BV188458 AI889340 AI123555 AA039479 BE677919 AF142099 BM716635 AI338748

highest scoring ESTs for ADAMTS5:

AF142099 AI084504 AI123555 F37480 AA046217 AA233151 AA233227 AA334544 AA362889 AA425042

Unigene Cluster for ADAMTS5:

ADAM metallopeptidase with thrombospondin type 1 motif, 5

Hs.58324 [show with all ESTs]

Unigene Representative Sequence: NM_007038

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000284987

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADAMTS5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS5

¹ / ² / ³

12 probe-sets matching ADAMTS5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54593_at²^{, 3}	U95-B	1	1.00	1.00	0.84	0.83	AI123555	0.80	1.00	0.91	1
80160_at²^{, 3}	U95-E	1	1.00	1.00	0.43	0.61	F37480	0.80	1.00	0.91	1
50533_at²^{, 3}	U95-B	1	1.00	1.00	0.73	1.30	AI084504	0.80	1.00	0.91	1
47321_at²^{, 3}	U95-B	1	1.00	1.00	0.67	1.03	W73846	0.60	1.00	0.82	1
50177_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.30	AA545730	0.40	1.00	0.76	1
219935_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007038	0.60	1.00	0.82	1
235368_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI123555	0.80	1.00	0.91	1
229357_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF060767	0.40	1.00	0.76	1
1558636_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219935_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235368_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229357_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADAMTS5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTTAAGTA

SOURCE GeneReport for Unigene cluster: Hs.58324
UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0
Tissue specificity: Expressed at low level in placenta primarily but also detected in heart and
brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a
joint capsule from an arthritic patient

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAMTS5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAMTS5¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	89.43(n) 95.02(a)	487713 XM_846025.1 XP_851118.1
chimpanzee (Pan troglodytes)	ADAMTS5¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	99.64(n) 99.68(a)	473935 XM_531407.2 XP_531407.2
cow (Bos taurus)	ADAMTS5¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	87.56(n) 92.04(a)	286805 XM_589193.2 XP_589193.2
rat (Rattus norvegicus)	Adamts5¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	85.97(n) 91.65(a)	304135 NM_198761.1 NP_942056.1
mouse (Mus musculus)	Adamts5^{1, 5}	16 (62.00 cM)⁵	a disintegrin-like and metallopeptidase (reprolysin more^{1, 5}	86.04(n)¹ 90.91(a)¹	23794¹ NM_011782.2¹ NP_035912.2¹ AA288689⁵ AF140673⁵ (see all 23)

About this table Species with no ortholog for ADAMTS5

ENSEMBL Gene Tree for ADAMTS5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAMTS5 gene

ADAMTS4² ADAMTS1² ADAMTS8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/321 NCBI SNPs in ADAMTS5 are shown (see all 321 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 216)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs151065^1,2	A,C,F,H,O	27218195(+)	`GCATCA/GGTGCT`	1	--	ut3¹		17	MN EU EA WA NA	2927
	rs226794^1,2	A,C,F,H,O	27224226(+)	`TGTACG/AGCCTA`	1	P/L	mis¹		19	MN EU EA WA NA	1665
	rs229070^1,2	C,F,H,O	27212808(+)	`AAATAC/GCATCC`	1	--	ut3¹ ese³		14	NS MN EU EA WA NA	916
	rs11700721^1,2	A,C,F,H	27215795(+)	`CAATTC/TGTGGT`	1	--	ut3¹ ese³		7	NA EU EA WA	552
	rs229077^1,2	A,C,F,O	27217210(+)	`ACAAAT/CGCATT`	1	--	ut3¹ ese³		9	MN NA EA	702
	rs229071^1,2	A,C,F,O	27212867(+)	`ACAGTA/GTGTTC`	1	--	ut3¹		2	MN NA	194
	rs229072^1,2	A,C,F,H	27214966(+)	`AAAAAA/TTAGTG`	1	--	ut3¹		20	EU EA WA NA	1773
	rs229078^1,2	A,C,F,H	27218006(+)	`TGTAAG/TCCCAG`	1	--	ut3¹ ese³		10	MN NA EU EA WA	912
	rs1444269^1,2	A,C,F,H	27213326(+)	`GAAAGA/GTGTTA`	1	--	ut3¹ ese³		12	EU EA WA NA	1198
	rs229073^1,2	A,C,F,H	27214988(+)	`TAAAAA/GACCTA`	1	--	ut3¹		13	EU EA WA NA	1066

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HapMap Linkage Disequilibrium images for ADAMTS5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605007

6 Novoseek disease relationships for ADAMTS5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	78.88	16	18328163 (2), 15800624 (2), 18240210 (2), 11801682 (1) (see all 8)
arthritis	53.79	7	18992360 (1), 12020478 (1), 18247274 (1)
necrosis	31.91	3	16806998 (1), 11520168 (1), 15880812 (1)
glioblastoma	16.06	9	16133547 (4), 16003758 (3)
rheumatoid arthritis	10.65	1	11801682 (1)
tumors	1.66	4	16003758 (1), 16806998 (1), 11520168 (1), 15880812 (1)

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Human Genome Epidemiology Navigator: ADAMTS5 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/90 PubMed articles for ADAMTS5 gene (see all 90 ):

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PubMed id 10438522)^{1, 2, 3, 4} Abbaszade I.... Burn T.C. (1999)
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)^{1, 3, 4} Hurskainen T.L.... Apte S.S. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). (PubMed id 12392761)^{1, 3} Tortorella M.D....Arner E. (2002)
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. (PubMed id 17430884)^{1, 3} Gendron C....Nagase H. (2007)
Expression and activity of ADAMTS-5 in synovium. (PubMed id 11231277)^{1, 3} Vankemmelbeke M.N....Buttle D.J. (2001)
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. (PubMed id 18156631)^{1, 3} Fushimi K....Nagase H. (2008)
Expression of ADAMTS-5 in deformed human temporomandibular joint discs. (PubMed id 18830934)^{1, 3} Matsumoto T....Fujita S. (2008)
Human glioblastomas overexpress ADAMTS-5 that degrades brevican. (PubMed id 16133547)^{1, 3} Nakada M....Okada Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 11096	HGNC: 221	AceView: ADAMTS5	Ensembl:ENSG00000154736	euGenes: HUgn11096
ECgene: ADAMTS5	H-InvDB: ADAMTS5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ADAMTS5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADAMTS5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAMTS5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAMTS5		Antibodies for ADAMTS5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAMTS5		Browse small molecules at Sigma-Aldrich
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Antibodies for ADAMTS5

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADAMTS5 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ADAMTS5

Summaries
for ADAMTS5

Genomic Location
for ADAMTS5

Proteins
for ADAMTS5

Protein Domains/
Families
for ADAMTS5

Gene Function
for ADAMTS5

Pathways & Interactions
for ADAMTS5

Drugs & Compounds
for ADAMTS5

Transcripts
for ADAMTS5

Expression
for ADAMTS5

Orthologs
for ADAMTS5

Paralogs
for ADAMTS5

SNPs/Variants
for ADAMTS5

Disorders & Mutations
for ADAMTS5

Medical News
for ADAMTS5

Publications
for ADAMTS5

Search for ADAMTS5

Genome Databases showing ADAMTS5

Other Databases showing ADAMTS5

Specialized Databases showing ADAMTS5

Licensable Technologies
for ADAMTS5

Services
for ADAMTS5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAMTS5 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ADAMTS5

Summariesfor ADAMTS5

Genomic Locationfor ADAMTS5

Proteinsfor ADAMTS5

Protein Domains/Familiesfor ADAMTS5

Gene Functionfor ADAMTS5

Pathways & Interactionsfor ADAMTS5

Drugs & Compoundsfor ADAMTS5

Transcriptsfor ADAMTS5

Expression for ADAMTS5

Orthologsfor ADAMTS5

Paralogsfor ADAMTS5

SNPs/Variantsfor ADAMTS5

Disorders & Mutationsfor ADAMTS5

Medical Newsfor ADAMTS5

Publicationsfor ADAMTS5

Search for ADAMTS5

Genome Databases showing ADAMTS5

Other Databases showing ADAMTS5

Specialized Databases showing ADAMTS5

Licensable Technologiesfor ADAMTS5

Servicesfor ADAMTS5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAMTS5

Summaries
for ADAMTS5

Genomic Location
for ADAMTS5

Proteins
for ADAMTS5

Protein Domains/
Families
for ADAMTS5

Gene Function
for ADAMTS5

Pathways & Interactions
for ADAMTS5

Drugs & Compounds
for ADAMTS5

Transcripts
for ADAMTS5

Expression
for ADAMTS5

Orthologs
for ADAMTS5

Paralogs
for ADAMTS5

SNPs/Variants
for ADAMTS5

Disorders & Mutations
for ADAMTS5

Medical News
for ADAMTS5

Publications
for ADAMTS5

Licensable Technologies
for ADAMTS5

Services
for ADAMTS5