ADAMTS5 Gene
protein-coding GIFtS : 63
GCID: GC21 M028290
ADAM metallopeptidase with thrombospondin type 1 motif,... (Previous names: a disintegrin-like and metalloprotease (reprolysin type)... )
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Aliasesfor ADAMTS5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb , and/or 11 Nature :405,311-319 and CroW21)About This Section Aliases ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 5 1 2 Disintegrin-Like And Metalloprotease With Thrombospondin Type 1 Motif, 511 ADAMTS111 2 3 5 A Disintegrin And Metalloproteinase With Thrombospondin Motifs 52 ADMP-21 2 3 Aggrecanase-23 A Disintegrin-Like And Metalloprotease (Reprolysin Type) With ThrombospondinType 1 Motif, 5 (Aggrecanase-2)1 2 ADMP23 A Disintegrin And Metalloproteinase With Thrombospondin Motifs 112 3 Aggrecanase-23 ADAM-TS52 3 EC 3.4.24.-3 ADAMTS-112 3 EC 3.4.248 ADAMTS-52 3 EC 3.4.24.148 ADAM-TS 112 3 EC 3.4.24.828 ADAM-TS 52 3
Export aliases for ADAMTS5 gene to outside databases Previous GC identifers: GC21M024872 GC21M027200 GC21M027215 GC21M013695
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Summariesfor ADAMTS5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ADAMTS5 : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 Function : Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important rolein the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period Gene Wiki entry for ADAMTS5
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Genomic Viewsfor ADAMTS5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
GC21M028290:
GeneLoc
Nature :405,311-319
Start:
28,290,231 bp from pter
13,871,628 bp from centromere
End:
28,339,439 bp from pter
13,916,697 bp from centromere
Size:
49,209 bases
45,070 bases
Orientation:
minus strand
minus strand
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Proteinsfor ADAMTS5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 (See
protein sequence )Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor Size : 930 amino acids; 101718 Da
Cofactor : Binds 1 zinc ion per subunit (By similarity)
Subcellular location : Secreted, extracellular space, extracellular matrix (By similarity)
6 PDB 3D structures from and Proteopedia for ADAMTS5 :2RJQ (3D)
  3B8Z (3D)
  3HY7 (3D)
  3HY9 (3D)
  3HYG (3D)
  3LJT (3D)
 
Secondary accessions : Q52LV4 Q9UKP2Explore the universe of human proteins at neXtProt for ADAMTS5: NX_Q9UNA0 Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UNA0 4/6 DME Specific Peptides for ADAMTS5 (Q9UNA0 ) (see all 6 )ADAMTS5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_008969.2 ENSEMBL proteins: ENSP00000284987 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ADAMTS5 for ontologies About GeneDecksing ADAMTS5 Antibody Products: Assay Products for ADAMTS5:
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Protein
Domains / Familiesfor ADAMTS5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ADAMTS5 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9UNA0 ProtoNet protein and cluster: Q9UNA0
5 Blocks protein families : IPB000884 Thrombospondin IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB008085 Thrombospondin type 1 repeat signature IPB010294 ADAM-TS Spacer 1 UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 Domain : The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellularmatrix Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 peptidase M12B domainSimilarity : Contains 2 TSP type-1 domains
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Functionfor ADAMTS5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 Function : Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important rolein the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period Catalytic activity : Cleaves aggrecan at the 392-Glu- -Ala-393 site
Genatlas biochemistry entry for ADAMTS5 : a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin type 1 motif 5,highly expressed in the peri-implantation period in mouse embryo and trophoblast and in adult tissues,extracellular matrix protein Enzyme Numbers (IUBMB): EC 3.4.24.- 1 EC 3.4.24.14 2 EC 3.4.24.82 2 EC 3.4.24 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAMTS5 (NM_007038 ) Sino Biological Human cDNA Clone for ADAMTS5 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAMTS5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS5
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
ADAMTS5 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for ADAMTS5 :Animal Models: Mouse knock-outs for ADAMTS5: Adamts5 tm1.1Lex Adamts5 tm1.1Eam 8 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Adamts5) :
ADAMTS5 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ADAMTS5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Endochondral Ossification 2 Cell adhesion_ECM remodeling
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for ADAMTS5 1 BioSystems Pathway for ADAMTS5
ADAMTS5 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS5 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/6 Interacting proteins for ADAMTS5 (Q9UNA0 1 , 3 ENSP00000284987 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006508 proteolysis
IEA --
ADAMTS5 for ontologies About GeneDecksing
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Drugs & Compoundsfor ADAMTS5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ADAMTS5 for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for ADAMTS5
Browse Tocris compounds for ADAMTS5 3 DrugBank Compounds for ADAMTS5 About this table 4 Novoseek chemical compound relationships for ADAMTS5 gene About this table
Search CenterWatch for drugs/clinical trials and news about ADAMTS5 / ATS5
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Transcriptsfor ADAMTS5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ADAMTS5 gene: NM_007038.3 Unigene Cluster for ADAMTS5:
ADAM metallopeptidase with thrombospondin type 1 motif, 5 Hs.58324 [show with all ESTs ] Unigene Representative Sequence: NM_007038 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000284987 (uc002ymg.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAMTS5 (NM_007038 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAMTS5
Additional cDNA sequence: AF086299.1 AF086358.1 AF141293.1 AF142099.1 AK094057.1 AK095905.1 BC093775.1 BC093777.1
4 DOTS entries : DT.205954 DT.102571
DT.121130367 DT.100675235 24/81 AceView cDNA sequences (see all 81 ):
BQ184915 BX498507 BM932138 CD515844 H89140 BM127085 AW612318 AA425042 AI269148 AI273671 BE856159 H88919 AW662679 AA495969 BV204252 AK094057 AL552429 BX105193 AI889340 BX503148 AA410337 CK818817 BX507026 AI084504 GeneLoc Exon Structure
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Expression for ADAMTS5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ADAMTS5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTTTTAAGTA
About this image ADAMTS5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ADAMTS5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ADAMTS5 SOURCE GeneReport for Unigene cluster: Hs.58324 UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 Tissue specificity : Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus,bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient SABiosciences Custom PCR Arrays for ADAMTS5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ADAMTS5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ADAMTS5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ADAMTS5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ADAMTS5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS5
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Orthologsfor ADAMTS5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ADAMTS5 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ADAMTS51
ADAM metallopeptidase with thrombospondin type 1 motif, more
79.31(n) 86.45(a)
 
427971 XM_425541.3 XP_425541.3
lizard (Anolis carolinensis)
Reptilia
ADAMTS56
--
84(a)
1 ↔ 1
3(147609151-147683920)
zebrafish (Danio rerio)
Actinopterygii
adamts51
ADAM metallopeptidase with thrombospondin type 1 motif, more
66.04(n) 69.35(a)
 
565053 XM_688362.5 XP_693454.5
fruit fly (Drosophila melanogaster)
Insecta
CG148696
--
14(a)
1 → many
3R(11267965-11301915)
worm (Caenorhabditis elegans)
Secernentea
mig-176 gon-16
ADAM family mig-17A disintegrin and metalloproteinase with thrombosp...
16(a) 12(a)
possible ortholog1 ↔ many
V(11446634-11449228) IV(9935046-9945754)
ENSEMBL Gene Tree for ADAMTS5 (if available)TreeFam Gene Tree for ADAMTS5 (if available)
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Paralogsfor ADAMTS5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ADAMTS5 gene ADAMTS17 2 ADAMTS18 2 ADAMTS6 2 ADAMTS12 2 ADAMTS20 2 ADAMTS4 2 ADAMTS16 2 ADAMTS9 2 ADAMTS10 2 ADAMTS7 2 ADAMTS1 2 ADAMTS19 2 ADAMTS14 2 ADAMTS2 2 ADAMTS15 2 ADAMTS8 2 ADAMTS3 2 10 SIMAP similar genes for ADAMTS5 using alignment to 1 protein entry: ATS5_HUMAN :ADAMTS4 ADAMTS1 DKFZp686E01144 ADAMTS15 ADAMTS8 ADAMTSL1 DKFZp434K1772 ADAMTS3 ADAMTS6 ADAMTS13
ADAMTS5 for paralogs About GeneDecksing
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Genomic Variantsfor ADAMTS5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ADAMTS5 (28290231 - 28339439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ADAMTS5: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ADAMTS5
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Disorders
/ Diseasesfor ADAMTS5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ADAMTS5 for disorders About GeneDecksing
OMIM gene information: 605007
OMIM disorders : --13 diseases for ADAMTS5 : About MalaCards myocardial infarction acute myocardial infarction chondroblastoma rheumatoid arthritis pick's disease down syndrome osteoarthritis arthritis chondrosarcoma glioblastoma fibrosis retinitis prostatitis 1 disease from the University of Copenhagen DISEASES database for ADAMTS5 :Osteoarthritis 6 Novoseek disease relationships for ADAMTS5 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis
79.2
18
18328163 (2), 15800624 (2), 18240210 (2), 11801682 (1) (see all 10 )
arthritis
51.5
7
18992360 (1), 12020478 (1), 18247274 (1)
necrosis
31.5
4
16806998 (1), 19217322 (1), 11520168 (1), 15880812 (1)
glioblastoma
12.7
9
16133547 (4), 16003758 (3)
rheumatoid arthritis
7.63
1
11801682 (1)
tumors
0
4
16003758 (1), 16806998 (1), 11520168 (1), 15880812 (1)
Human Genome Epidemiology (HuGE) Navigator: ADAMTS5 (3 documents) Export disorders for ADAMTS5 gene to outside databases
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Publicationsfor ADAMTS5 gene (in
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Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ADAMTS5 gene, integrated from 9 sources (see all 119 ): (articles sorted by number of sources associating them with ADAMTS5) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PubMed id 10438522) 1 , 2 , 3, 9 Abbaszade I.... Burn T.C. (1999) ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288) 1 , 2 , 9 Hurskainen T.L.... Apte S.S. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence of human chromosome 21. (PubMed id 10830953) 1 , 2 Hattori M....Yaspo M.L. (2000) Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). (PubMed id 12392761) 1 , 9 Tortorella M.D....Arner E. (2002) Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. (PubMed id 17430884) 1 , 9 Gendron C....Nagase H. (2007) Expression and activity of ADAMTS-5 in synovium. (PubMed id 11231277) 1 , 9 Vankemmelbeke M.N....Buttle D.J. (2001) Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. (PubMed id 18156631) 1 , 9 Fushimi K....Nagase H. (2008) Expression of ADAMTS-5 in deformed human temporomandibular joint discs. (PubMed id 18830934) 1 , 9 Matsumoto T....Fujita S. (2008) Human glioblastomas overexpress ADAMTS-5 that degrades brevican. (PubMed id 16133547) 1 , 9 Nakada M....Okada Y. (2005)
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Specialized Databases showing ADAMTS5 gene (According to PharmGKB ,
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PharmGKB entry for ADAMTS5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ADAMTS5 gene: Search GeneIP for patents involving ADAMTS5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ADAMTS5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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