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ADAMTS5 Gene

protein-coding   GIFtS: 67
GCID: GC21M028290

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 51 2     ADAM-TS 52 3
ADAMTS112 3 5     Disintegrin-Like And Metalloprotease With Thrombospondin Type 1 Motif, 511
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 5 (Aggrecanase-2)1 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 52
aggrecanase-21 2     ADMP23
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 112 3     Aggrecanase-23
ADAM-TS52 3     EC 3.4.24.-3
ADAMTS-112 3     EC 3.4.248
ADAMTS-52 3     EC 3.4.24.148
ADMP-22 3     EC 3.4.24.828
ADAM-TS 112 3     

External Ids:    HGNC: 2211   Entrez Gene: 110962   Ensembl: ENSG000001547367   OMIM: 6050075   UniProtKB: Q9UNA03   

Export aliases for ADAMTS5 gene to outside databases

Previous GC identifers: GC21M024872 GC21M027200 GC21M027215 GC21M013695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS5 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme
encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major
proteoglycan of cartilage. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS5 Gene:
ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important
role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly
during the peri-implantation period

Gene Wiki entry for ADAMTS5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS5 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   AP-1   ATF-2   E2F-2   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS5 promoter sequence

   Search Chromatin IP Primers for ADAMTS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q21.3
ADAMTS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS5 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M028290:   GeneLoc Nature:405,311-319
Start:
28,290,231 bp from pter       13,871,628 bp from centromere
End:
28,339,439 bp from pter 13,916,697 bp from centromere
Size:
49,209 bases 45,070 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: NM_007038
genomic clones: KB45E1 KB1346F10


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor  
Size: 930 amino acids; 101718 Da
Cofactor: Binds 1 zinc ion per subunit
6 PDB 3D structures from and Proteopedia for ADAMTS5:
2RJQ (3D)        3B8Z (3D)        3HY7 (3D)        3HY9 (3D)        3HYG (3D)        3LJT (3D)    
Secondary accessions: Q52LV4 Q9UKP2

Explore the universe of human proteins at neXtProt for ADAMTS5: NX_Q9UNA0

Explore proteomics data for ADAMTS5 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of
    ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the
    consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Thr36, Ser208, Ser214, Thr215, Asn498, Trp570, Trp573, Ser582, Asn728, Asn802,
                                 Asn807
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAMTS5 (Q9UNA0) (see all 6)
     RYSFFVP  VCGGDNS  VIEDDGL  CSRSCGGG 


    See ADAMTS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008969.2  
    ENSEMBL proteins: 
     ENSP00000284987  
    Reactome Protein details: Q9UNA0

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    antibodies-online proteins for ADAMTS5 (8 products) 

     
    antibodies-online peptides for ADAMTS5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS5
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR013276 Pept_M12B_ADAM-TS5
     IPR024079 MetalloPept_cat_dom
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry Q9UNA0

    ProtoNet protein and cluster: Q9UNA0

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 2 TSP type-1 domains


    Find genes that share domains with ADAMTS5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS5_HUMAN, Q9UNA0
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important
    role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly
    during the peri-implantation period
    Catalytic activity: Cleaves aggrecan at the 392-Glu- -Ala-393 site

         Genatlas biochemistry entry for ADAMTS5:
    a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin type 1 motif
    5,highly expressed in the peri-implantation period in mouse embryo and trophoblast and in adult
    tissues,extracellular matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS10438522
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity TAS10438522
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADAMTS5:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Adamts5):
     behavior/neurological  cellular  immune system  integument  limbs/digits/tail 
     normal  reproductive system  skeleton 

    Find genes that share phenotypes with ADAMTS5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADAMTS5: Adamts5tm1.1Lex Adamts5tm1.1Eam

       genOway: Develop your customized and physiologically relevant rodent model for ADAMTS5

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    hsa-mir-98-5p (MIRT027846)

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    hsa-miR-411* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS5_HUMAN, Q9UNA0: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    nucleus4
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with ADAMTS5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAMTS5 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    3Notch Signaling Pathway (sino)
    Notch Signaling Pathway
    4Endochondral Ossification
    Endochondral Ossification


    Find genes that share SuperPaths with ADAMTS5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADAMTS5
        Endochondral Ossification

    1 Sino Biological Pathway for ADAMTS5
        Notch Signaling Pathway

    2 Reactome Pathways for ADAMTS5
        O-glycosylation of TSR domain-containing proteins
    Degradation of the extracellular matrix


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS5
    Interactions:

        GeneGlobe Interaction Network for ADAMTS5

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ADAMTS5 (Q9UNA01, 3 ENSP000002849874) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP13P454523, ENSP000002603024I2D: score=1 STRING: ENSP00000260302
    TIMP3ENSP000002660854STRING: ENSP00000266085
    UBCENSP000003448184STRING: ENSP00000344818
    ACANP136081EBI-2808663,EBI-6259246
    --E7EX883I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10438522
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with ADAMTS5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADAMTS5
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS5 (ATS5)

    3 DrugBank Compounds for ADAMTS5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide-- --target--10592235
    Batimastat-- 130370-60-4target--10592235
    N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide-- --target--10592235

    4 Novoseek inferred chemical compound relationships for ADAMTS5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 61 6 16507336 (2), 11817583 (1), 17763444 (1)
    retinoic acid 21.3 1 11231277 (1)
    heparin 11.4 3 16507336 (2), 11231277 (1)
    zinc 9.64 3 10464288 (2), 18799682 (1)



    Find genes that share compounds with ADAMTS5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMTS5 gene: 
    NM_007038.3  

    Unigene Cluster for ADAMTS5:

    ADAM metallopeptidase with thrombospondin type 1 motif, 5
    Hs.58324  [show with all ESTs]
    Unigene Representative Sequence: NM_007038
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000284987(uc002ymg.3)
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    Additional mRNA sequence: 

    AF086299.1 AF086358.1 AF141293.1 AF142099.1 AK094057.1 AK095905.1 BC093775.1 BC093777.1 

    4 DOTS entries:

    DT.205954  DT.102571  DT.121130367  DT.100675235 

    Selected AceView cDNA sequences (see all 81):

    CD515844 H89140 AI273671 AW612318 H88919 BM932138 AA425042 AI269148 
    BQ184915 BX498507 BM127085 BE856159 AF142099 AA495969 AI375941 BU738180 
    AI889340 BF589952 AF141293 AA233227 BM716635 BQ186712 BX105193 AL598390 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTAAGTA
    ADAMTS5 Expression
    About this image


    ADAMTS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
    ADAMTS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58324

    UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0
    Tissue specificity: Expressed at low level in placenta primarily but also detected in heart and brain, cervix,
    uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic
    patient

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts51 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 85.86(n)1
    90.8(a)1
      16 (48.34 cM)5
    237941  NM_011782.21  NP_035912.21 
     858581705 
    chicken
    (Gallus gallus)
    Aves ADAMTS51 ADAM metallopeptidase with thrombospondin type 1 motif, more 78.85(n)
    85.52(a)
      427971  XM_425541.4  XP_425541.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS56
    ADAM metallopeptidase with thrombospondin type 1 m...
    83(a)
    1 ↔ 1
    3(147609082-147683920)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts51 ADAM metallopeptidase with thrombospondin type 1 motif, more 71.49(n)
    76.46(a)
      100488158  XM_002935694.2  XP_002935740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adamts51 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.83(n)
    70.62(a)
      565053  XM_688362.6  XP_693454.6 


    ENSEMBL Gene Tree for ADAMTS5 (if available)
    TreeFam Gene Tree for ADAMTS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS5 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    9 SIMAP similar genes for ADAMTS5 using alignment to 1 protein entry:     ATS5_HUMAN:
    ADAMTS4    ADAMTS1    DKFZp686E01144    ADAMTS15    ADAMTS8    ADAMTSL1
    DKFZp434K1772    ADAMTS3    ADAMTS6

    Find genes that share paralogs with ADAMTS5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS5 (see all 1069)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402522471,2
    C--28289755(+) TGTACA/GCTAAA 1 -- ds50010--------
    rs670466061,2
    C--28289857(+) TTTTT-/TAAAAT 1 -- ds50012Minor allele frequency- T:0.25NA 4
    rs49973361,2
    C--28289867(+) TTTTTT/ATTAAT 1 -- ds50012Minor allele frequency- A:0.25NA 4
    rs24091941,2
    --28289868(+) TTTTTT/ATAATT 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs2290671,2
    C,A,H--28289869(+) TTTTTA/TAATTT 1 -- ds50016Minor allele frequency- T:0.22NA WA EA 366
    rs1503531941,2
    C--28289978(+) TTCTAA/CTTTAA 1 -- ds50010--------
    rs2290681,2
    C,F,A,H--28290149(+) ACCCAC/GCTTGG 1 -- ds500115Minor allele frequency- G:0.44NA EA WA CSA 628
    rs1380704331,2
    C--28290239(+) TTTAAC/GCTAGT 1 -- ut310--------
    rs772928691,2
    C,F--28290289(+) GCAGTG/TTTTAA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1904006351,2
    C--28290311(+) AAAGTA/CACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAMTS5 (28290231 - 28339439 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADAMTS5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659668CNV Deletion23128226
    nsv834068CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605007    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ADAMTS5:
    Osteoarthritis

    Find genes that share disorders with ADAMTS5           About GenesLikeMe

    6 Novoseek inferred disease relationships for ADAMTS5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 79.2 18 18328163 (2), 15800624 (2), 18240210 (2), 11801682 (1) (see all 10)
    arthritis 51.5 7 18992360 (1), 12020478 (1), 18247274 (1)
    necrosis 31.5 4 16806998 (1), 19217322 (1), 11520168 (1), 15880812 (1)
    glioblastoma 12.7 9 16133547 (4), 16003758 (3)
    rheumatoid arthritis 7.63 1 11801682 (1)
    tumors 0 4 16003758 (1), 16806998 (1), 11520168 (1), 15880812 (1)

    Genetic Association Database (GAD): ADAMTS5
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS5 (3 documents)

    Export disorders for ADAMTS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS5 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with ADAMTS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PubMed id 10438522)1, 2, 3, 9 Abbaszade I.... Burn T.C. (J. Biol. Chem. 1999)
    2. Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. (PubMed id 18240210)1, 4, 9 Rodriguez-Lopez J....Gonzalez A. (Arthritis Rheum. 2008)
    3. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 2, 9 Hurskainen T.L.... Apte S.S. (J. Biol. Chem. 1999)
    4. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1, 4 Zintzaras E....Karachalios T. (Am. J. Epidemiol. 2010)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. (PubMed id 18042673)1, 2 Mosyak L....Somers W. (Protein Sci. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    9. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). (PubMed id 12392761)1, 9 Tortorella M.D....Arner E. (Matrix Biol. 2002)
    10. Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. (PubMed id 17430884)1, 9 Gendron C....Nagase H. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11096 HGNC: 221 AceView: ADAMTS5 Ensembl:ENSG00000154736 euGenes: HUgn11096
    ECgene: ADAMTS5 H-InvDB: ADAMTS5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS5 gene:
    Search GeneIP for patents involving ADAMTS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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