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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAMTS5 Gene

protein-coding GIFtS: 63
GCID: GC21M028290

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)

Explore 13 diseases affiliated with
ADAMTS5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 5¹ ²		Disintegrin-Like And Metalloprotease With Thrombospondin Type 1 Motif, 511
ADAMTS11¹ ² ³ ⁵		A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5²
ADMP-2¹ ² ³		Aggrecanase-2³
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2)¹ ²		ADMP2³
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11² ³		Aggrecanase-2³
ADAM-TS5² ³		EC 3.4.24.-³
ADAMTS-11² ³		EC 3.4.24⁸
ADAMTS-5² ³		EC 3.4.24.14⁸
ADAM-TS 11² ³		EC 3.4.24.82⁸
ADAM-TS 5² ³

External Ids:	HGNC: 221¹	Entrez Gene: 11096²	Ensembl: ENSG00000154736⁷	OMIM: 605007⁵	UniProtKB: Q9UNA0³

Export aliases for ADAMTS5 gene to outside databases

Previous GC identifers: GC21M024872 GC21M027200 GC21M027215 GC21M013695

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS5:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein

family. Members of the family share several distinct protein modules, including a propeptide region, a

metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of

this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded

by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan

of cartilage. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role

in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the

peri-implantation period

Gene Wiki entry for ADAMTS5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAMTS5 gene promoter:
E2F-4 E2F-3a E2F-5 Sp1 AP-1 ATF-2 E2F-2 E2F-1 E2F c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS5 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAMTS5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band: 21q21.3

ADAMTS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS5 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M028290:	GeneLoc	Nature:405,311-319
Start:	28,290,231 bp from pter	13,871,628 bp from centromere
End:	28,339,439 bp from pter	13,916,697 bp from centromere
Size:	49,209 bases	45,070 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	NM_007038
genomic clones:	KB45E1 KB1346F10

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor

Size: 930 amino acids; 101718 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

6 PDB 3D structures from and Proteopedia for ADAMTS5:

2RJQ (3D)

3B8Z (3D)

3HY7 (3D)

3HY9 (3D)

3HYG (3D)

3LJT (3D)

Secondary accessions: Q52LV4 Q9UKP2

Explore the universe of human proteins at neXtProt for ADAMTS5: NX_Q9UNA0

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence

C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the

repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose

residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family

members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence

W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)¹

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence

C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the

repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose

residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.

Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence

W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UNA0

4/6 DME Specific Peptides for ADAMTS5 (Q9UNA0) (see all 6)

RYSFFVP

VCGGDNS

VIEDDGL

CSRSCGGG

ADAMTS5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_008969.2

ENSEMBL proteins:

ENSP00000284987

Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for ADAMTS5
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADAMTS5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

ADAMTS5 for ontologies About GeneDecksing

ADAMTS5 Antibody Products:

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	Abcam antibodies for ADAMTS5
	Uscn Antibodies for ADAMTS5
	ThermoFisher Antibody for ADAMTS5

Assay Products for ADAMTS5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAMTS5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADAMTS5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAMTS5 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000884 Thrombospondin_1_rpt

IPR013276 Pept_M12B_ADAM-TS5

IPR024079 MetalloPept_cat_dom

IPR010294 ADAM_spacer1

IPR001590 Peptidase_M12B

Graphical View of Domain Structure for InterPro Entry Q9UNA0

ProtoNet protein and cluster: Q9UNA0

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular

matrix

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 2 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role

in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the

peri-implantation period

Catalytic activity: Cleaves aggrecan at the 392-Glu- -Ala-393 site

Genatlas biochemistry entry for ADAMTS5:

a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 2,with thrombospondin type 1 motif 5,highly

expressed in the peri-implantation period in mouse embryo and trophoblast and in adult tissues,extracellular matrix

protein

Enzyme Numbers (IUBMB): EC 3.4.24.-¹ EC 3.4.24.14² EC 3.4.24.82² EC 3.4.24²

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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	TAS	10438522
GO:0005515	protein binding	IPI	--
GO:0008237	metallopeptidase activity	TAS	10438522
GO:0008270	zinc ion binding	IEA	--

ADAMTS5 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ADAMTS5:

Decreased Salmonella enterica

Decreased Salmonella-containin

Animal Models:
Mouse knock-outs for ADAMTS5: Adamts5^tm1.1Lex Adamts5^tm1.1Eam
8 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Adamts5):

behavior/neurological	cellular	immune system	integument	limbs/digits/tail
normal	reproductive system	skeleton

ADAMTS5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endochondral Ossification

Endochondral Ossification

1.00

Cell adhesion_ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADAMTS5

Metalloproteases in connective tissue degradation

1 BioSystems Pathway for ADAMTS5

Endochondral Ossification

ADAMTS5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADAMTS5

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for ADAMTS5 (Q9UNA0^{1, 3} ENSP00000284987⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP13	P45452³, ENSP00000260302⁴	I2D: score=1 STRING: ENSP00000260302
TIMP3	ENSP00000266085⁴	STRING: ENSP00000266085
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ACAN	P13608¹	EBI-2808663,EBI-6259246
--	E7EX88³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

ADAMTS5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADAMTS5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ADAMTS5

Browse Tocris compounds for ADAMTS5

3 DrugBank Compounds for ADAMTS5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide	--	--	target	--	10592235
Batimastat	--	130370-60-4	target	--	10592235
N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide	--	--	target	--	10592235

4 Novoseek chemical compound relationships for ADAMTS5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	61	6	16507336 (2), 11817583 (1), 17763444 (1)
retinoic acid	21.3	1	11231277 (1)
heparin	11.4	3	16507336 (2), 11231277 (1)
zinc	9.64	3	10464288 (2), 18799682 (1)

Search CenterWatch for drugs/clinical trials and news about ADAMTS5 / ATS5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAMTS5 gene:

NM_007038.3

Unigene Cluster for ADAMTS5:

ADAM metallopeptidase with thrombospondin type 1 motif, 5

Hs.58324 [show with all ESTs]

Unigene Representative Sequence: NM_007038

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000284987(uc002ymg.3)

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		hsa-miR-411* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AF086299.1 AF086358.1 AF141293.1 AF142099.1 AK094057.1 AK095905.1 BC093775.1 BC093777.1

4 DOTS entries:

DT.205954 DT.102571 DT.121130367 DT.100675235

24/81 AceView cDNA sequences (see all 81):

BQ184915 BX498507 BM932138 CD515844 H89140 BM127085 AW612318 AA425042

AI269148 AI273671 BE856159 H88919 AW662679 AA495969 BV204252 AK094057

AL552429 BX105193 AI889340 BX503148 AA410337 CK818817 BX507026 AI084504

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAMTS5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTAAGTA

About this image

ADAMTS5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Reproductive System

Visceral White Adipose

Adipose

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Epiblast-like cells (Reconstitution of mo...)

See ADAMTS5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAMTS5

SOURCE GeneReport for Unigene cluster: Hs.58324

UniProtKB/Swiss-Prot: ATS5_HUMAN, Q9UNA0

Tissue specificity: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus,

bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient

SABiosciences Custom PCR Arrays for ADAMTS5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS5 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADAMTS5¹	ADAM metallopeptidase with thrombospondin type 1 motif, more	79.31(n) 86.45(a)		427971 XM_425541.3 XP_425541.3
lizard (Anolis carolinensis)	Reptilia	ADAMTS5⁶	--	84(a)	1 ↔ 1	3(147609151-147683920)
zebrafish (Danio rerio)	Actinopterygii	adamts5¹	ADAM metallopeptidase with thrombospondin type 1 motif, more	66.04(n) 69.35(a)		565053 XM_688362.5 XP_693454.5
fruit fly (Drosophila melanogaster)	Insecta	CG14869⁶	--	14(a)	1 → many	3R(11267965-11301915)
worm (Caenorhabditis elegans)	Secernentea	mig-17⁶ gon-1⁶	ADAM family mig-17 A disintegrin and metalloproteinase with thrombosp...	16(a) 12(a)	possible ortholog 1 ↔ many	V(11446634-11449228) IV(9935046-9945754)

ENSEMBL Gene Tree for ADAMTS5 (if available)
TreeFam Gene Tree for ADAMTS5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAMTS5 gene

ADAMTS17² ADAMTS18² ADAMTS6² ADAMTS12² ADAMTS20² ADAMTS4² ADAMTS16² ADAMTS9²

ADAMTS10² ADAMTS7² ADAMTS1² ADAMTS19² ADAMTS14² ADAMTS2² ADAMTS15² ADAMTS8²

ADAMTS3²

10 SIMAP similar genes for ADAMTS5 using alignment to 1 protein entry: ATS5_HUMAN:

ADAMTS4 ADAMTS1 DKFZp686E01144 ADAMTS15 ADAMTS8 ADAMTSL1

DKFZp434K1772 ADAMTS3 ADAMTS6 ADAMTS13

ADAMTS5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140252247^1,2		--	28289755(+)	`TGTACA/GCTAAA`	1	--	ds500¹		0	--	--	--	--
rs67046606^1,2	C	--	28289857(+)	`TTTTT-/TAAAAT`	1	--	ds500¹		2		NA	4
rs2409194^1,2		--	28289868(+)	`TTTTTT/ATAATT`	1	--	ds500¹		1		NA	2
rs58215296^1,2	C,	--	28289869(+)	`TTTTTA/TAATTT`	1	--	ds500¹		6		NA WA EA	366
rs150353194^1,2		--	28289978(+)	`TTCTAA/CTTTAA`	1	--	ds500¹		0	--	--	--	--
rs229068^1,2	C,F,A,H,	--	28290149(+)	`ACCCAC/GCTTGG`	1	--	ds500¹		15		NA EA WA CSA	628
rs138070433^1,2		--	28290239(+)	`TTTAAC/GCTAGT`	1	--	ut3¹		0	--	--	--	--
rs77292869^1,2	F,	--	28290289(+)	`GCAGTG/TTTTAA`	1	--	ut3¹		1		WA	118
rs190400635^1,2		--	28290311(+)	`AAAGTA/CACACA`	1	--	ut3¹		0	--	--	--	--
rs182551620^1,2		--	28290592(+)	`AGCAGC/TGTACA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADAMTS5 (28290231 - 28339439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAMTS5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS5

DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAMTS5 for disorders           About GeneDecksing

OMIM gene information: 605007    OMIM disorders: --

13 diseases for ADAMTS5:    About MalaCards

myocardial infarction acute myocardial infarction chondroblastoma rheumatoid arthritis

pick's disease down syndrome osteoarthritis arthritis

chondrosarcoma glioblastoma fibrosis retinitis

prostatitis

1 disease from the University of Copenhagen DISEASES database for ADAMTS5:

Osteoarthritis

6 Novoseek disease relationships for ADAMTS5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	79.2	18	18328163 (2), 15800624 (2), 18240210 (2), 11801682 (1) (see all 10)
arthritis	51.5	7	18992360 (1), 12020478 (1), 18247274 (1)
necrosis	31.5	4	16806998 (1), 19217322 (1), 11520168 (1), 15880812 (1)
glioblastoma	12.7	9	16133547 (4), 16003758 (3)
rheumatoid arthritis	7.63	1	11801682 (1)
tumors	0	4	16003758 (1), 16806998 (1), 11520168 (1), 15880812 (1)

Human Genome Epidemiology (HuGE) Navigator: ADAMTS5 (3 documents)

Export disorders for ADAMTS5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADAMTS5 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with ADAMTS5)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. (PubMed id 10438522)^{1, 2, 3, 9} Abbaszade I.... Burn T.C. (1999)
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)^{1, 2, 9} Hurskainen T.L.... Apte S.S. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). (PubMed id 12392761)^{1, 9} Tortorella M.D....Arner E. (2002)
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. (PubMed id 17430884)^{1, 9} Gendron C....Nagase H. (2007)
Expression and activity of ADAMTS-5 in synovium. (PubMed id 11231277)^{1, 9} Vankemmelbeke M.N....Buttle D.J. (2001)
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. (PubMed id 18156631)^{1, 9} Fushimi K....Nagase H. (2008)
Expression of ADAMTS-5 in deformed human temporomandibular joint discs. (PubMed id 18830934)^{1, 9} Matsumoto T....Fujita S. (2008)
Human glioblastomas overexpress ADAMTS-5 that degrades brevican. (PubMed id 16133547)^{1, 9} Nakada M....Okada Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11096	HGNC: 221	AceView: ADAMTS5	Ensembl:ENSG00000154736	euGenes: HUgn11096
ECgene: ADAMTS5	H-InvDB: ADAMTS5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADAMTS5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAMTS5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADAMTS5 gene:
Search GeneIP for patents involving ADAMTS5

GeneCards and IP:
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ADAMTS5 Gene

ADAM metallopeptidase with thrombospondin type 1 motif,...

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ADAMTS5 (Gene Symbol)
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 5
ADAMTS11
ADMP-2
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2)
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11
ADAM-TS5
ADAMTS-11
ADAMTS-5
ADAM-TS 11
ADAM-TS 5
Disintegrin-Like And Metalloprotease With Thrombospondin Type 1 Motif, 5
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5
Aggrecanase-2
ADMP2
Aggrecanase-2
EC 3.4.24.-
EC 3.4.24
EC 3.4.24.14
EC 3.4.24.82

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ADAMTS5 Gene

ADAM metallopeptidase with thrombospondin type 1 motif,...

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