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ADAMTS4 Gene

protein-coding   GIFtS: 62

GC01M159426
ADAM metallopeptidase with thrombospondin type 1 motif, 4
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for ADAMTS4

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ADAM-TS4 3
ADAMTS-2 1, 2
ADAMTS-4 2, 3
ADMP-1 1, 2, 3
Aggrecanase-1 3
EC 3.4.24.82 3
KIAA0688 1, 2, 3
OTTHUMP00000032249 2
aggrecanase-1 2
Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 4 2
ADAM-TS 4 3
a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 4 1, 2
External Ids
HGNC: 2201
Entrez Gene: 95072
UniProtKB: O751733
Ensembl: ENSG000001588597
Search outside databases for aliases for ADAMTS4 gene

Previous GC identifers: GC01M158870 GC01M156891 GC01M157937 GC01M158376 GC01M157972

Summaries
for ADAMTS4

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ADAMTS4:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin
motifs) protein family. Members of the family share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin
type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,
and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS
motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and
brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican
suggests key roles of this enzyme in arthritic disease and in the central nervous system,
potentially, in the progression of glioma. [provided by RefSeq]

UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play
an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical
factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the
'392-Glu- -Ala-393' site

Gene Wiki entry for ADAMTS4

Genomic Location
for ADAMTS4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADAMTS4 gene  

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q31-q32

ADAMTS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159426:     (about GC identifiers)

Start:
 159,426,162 bp from pter
End:
 159,435,469 bp from pter
Size:
 9,308 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  

Proteins
for ADAMTS4

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 4 precursor  
Size: 837 amino acids; 90225 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Caution: Has sometimes been referred to as ADAMTS2
PDB structure from and Proteopedia :
2RJP (3D)    3B2Z (3D)    
Secondary accessions: Q5VTW2 Q6P4Q8 Q6UWA8 Q9UN83

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase1


    • REFSEQ proteins: NP_005090.3  

    ENSEMBL proteins: 
    ENSP00000356975 ENSP00000356974 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ADAMTS4 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ADAMTS4
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADAMTS4)
    Human Recombinant Proteins from Abnova (ADAMTS4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    GO:0005615 extracellular space IDA14744861
    About this table

    Antibodies for ADAMTS4: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS4
    Sigma-Aldrich Antibodies for ADAMTS4
    R&D Systems Antibodies for ADAMTS4
    Antibodies from Abcam (ADAMTS4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ADAMTS4)
    Novus Biologicals Antibodies for ADAMTS4

    Assays for ADAMTS4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ADAMTS4

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro domains/families (see all 7 ):
     IPR000884 Thrombospondin_1_rpt
     IPR018358 Disintegrin_CS
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR006025 Pept_M_Zn_BS


       GeneDecks  ADAMTS4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O75173

    ProtoNet protein and cluster: O75173

    4 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the
    extracellular matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,
    thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the
    activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 TSP type-1 domain

    Gene Function
    for ADAMTS4

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADAMTS4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005099

                  Applied Biosystems Silencer® siRNAs for ADAMTS4

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS4  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ADAMTS4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005099
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005099
                                     untagged cDNA clone in CMV expression vector: NM_005099 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005099

    UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play
    an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical
    factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the
    '392-Glu- -Ala-393' site
    Catalytic activity: Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-
    -Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan
    Induction: By interleukin-1
    Enzyme Number (IUBMB): EC 3.4.24.82 

    Genatlas biochemistry entry for ADAMTS4:
    a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 1,with thrombospondin
    type 1 motif 4,potentially degrading aggrecan in arthritis disease,extracellular matrix protein

    6 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Adamts4):

    behavior/neurologicalhomeostasis/metabolismnervous systemno phenotypic analysisnormal
    skeleton

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020 protease binding IPI14744861
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0008233 peptidase activity TAS10751421
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ADAMTS4

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for ADAMTS4
     Metalloproteases in connective tissue degradation

       GeneDecks  ADAMTS4 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  ADAMTS4  (Your Favorite Gene powered by Ingenuity) 
     Lysine Degradation

       GeneDecks  ADAMTS4 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  ADAMTS4 


    5/24 Interacting proteins for ADAMTS4 (ENSP000003569753) via UniProtKB, MINT, and/or STRING (see all 24 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINENSP000002681713STRING (score=.978)
    MMP17ENSP000003537673STRING (score=.951)
    ACANENSP000002681343STRING (score=.939)
    POLD3ENSP000002636813STRING (score=.935)
    BCANENSP000003312103STRING (score=.901)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501 skeletal system development TAS10356395
    GO:0006508 proteolysis TAS10751421
    About this table

    Drugs & Compounds
    for ADAMTS4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADAMTS4
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADAMTS4
    4 Novoseek chemical compound relationships for ADAMTS4 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 68.94 11 16507336 (1), 11817583 (1), 17208315 (1), 17763444 (1) (see all 6)
    chondroitin sulfate 52.00 18 16945513 (7), 10751421 (1), 10998358 (1), 14701864 (1)
    tgf beta1 33.34 2 15599946 (1), 15883123 (1)
    nitric oxide 0.08 3 16806998 (1), 15922185 (1), 17605605 (1)
    About this table


    Transcripts
    for ADAMTS4

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADAMTS4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005099

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS4  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005099  

    REFSEQ mRNAs for ADAMTS4 gene: 

    NM_005099.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005099  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005099
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005099
                                     untagged cDNA clone in CMV expression vector: NM_005099 

    Additional cDNA sequence: 

    AB014588.1 AF148213.1 AK291573.1 AY358886.1 BC063293.1 DQ364570.1 

    5 DOTS entries:

    DT.40295660  DT.403409  DT.97766329  DT.100707470  DT.92419173 

    24/33 AceView cDNA sequences (see all 33 ):

    AI682879 AB014588 AY358886 AA603151 NM_005099 AL712592 AI678879 BF771897 
    BC030812 BP349742 AL603427 BC063293 BQ694677 CD619814 BP342809 BX503840 
    BG704864 AF148213 BM069747 BI602707 D45652 BM069515 CD619811 CD619809 

    highest scoring ESTs for ADAMTS4:

    AB014588 AF148213 AL603427 AL712592 AY358886 BC063293 BG540485 BI602707 BM069747 BX503840 

    Unigene Cluster for ADAMTS4:

    ADAM metallopeptidase with thrombospondin type 1 motif, 4
    Hs.211604  [show with all ESTs]
    Unigene Representative Sequence: NM_005099


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS4

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                      -           -                     
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for ADAMTS4

    2 Ensembl transcripts including schematic representations:
    ENST00000367996  ENST00000367995  

    Expression
    for ADAMTS4

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADAMTS4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS4

    1 / 2 / 3

    2 probe-sets matching ADAMTS4 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		63906_f_at2, 3 U95-C 3341 0.75 0.00 1.00 1.00 R98835 0.20 0.02 0.14 1

    		1555380_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCTCTGAGCA

    SOURCE GeneReport for Unigene cluster: Hs.211604

    UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173
    Tissue specificity: Expressed in brain, lung and heart. Expressed at very low level in placenta and
    skeletal muscles

    Orthologs
    for ADAMTS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ADAMTS4 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ADAMTS41   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 87.77(n)
    92.35(a)    		 488651  XM_545768.2  XP_545768.2 
    chimpanzee
    (Pan troglodytes)    		 ADAMTS41   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 99.72(n)
    99.64(a)    		 457453  XM_513940.2  XP_513940.2 
    cow
    (Bos taurus)    		 ADAMTS41   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 89.7(n)
    92.34(a)    		 286806  NM_181667.1  NP_858053.1 
    rat
    (Rattus norvegicus)    		 Adamts41   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 85(n)
    86.49(a)    		 66015  XM_341154.3  XP_341155.3 
    mouse
    (Mus musculus)    		 Adamts41, 5 1 (92.30 cM)5
    		 a disintegrin-like and metallopeptidase (reprolysin more1, 5 87.3(n)1
    90.99(a)1    		 2409131  NM_172845.21  NP_766433.11 
     AA0419735  AA5473255  (see all 17)
    About this table        Species with no ortholog for ADAMTS4

    ENSEMBL Gene Tree for ADAMTS4

    Paralogs
    for ADAMTS4

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADAMTS4 gene
    ADAMTS12  ADAMTS82  ADAMTS52  

    SNPs/Variants
    for ADAMTS4

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/47 NCBI SNPs in ADAMTS4 are shown (see all 47 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs42333671,2
    		A,C,F,H159429661(+) GTGCCC/TGGGCC 1 Q/R mis1 ese38Minor allele frequency- T:0.29EU EA WA 838
    rs42333661,2
    		A,C,F,H159425771(+) CAGTGC/TTCTTT 1 -- ng518Minor allele frequency- T:0.39EU EA WA 828
    --
    rs115835891,2
    		A,C159425782(+) ctactG/TTTGTG 1 -- ng510--------
    rs118073501,2
    		C,H159427559(+) ATTTCC/TTGCCC 1 R/K mis1 ese34Minor allele frequency- T:0.00EU EA WA 416
    --
    rs178558131,2
    		H159433018(+) CGAGTC/TCTCAG 1 D/N mis1 ese34Minor allele frequency- T:0.00EU EA WA 414
    --
    rs124049511,2
    		C159427191(+) CCCCAA/GGACCC 1 -- ut31 ese30--------
    rs31346671,2
    		C159428522(-) GGGACA/C/GGTTCT 2 G/S G/R mis1 ese30--------
    --
    rs178558121,2
    		H159432035(+) GAGCAT/CGTTGA 1 V/M mis14Minor allele frequency- C:0.00EU EA WA 416
    --
    rs178558161,2
    		H159430099(+) GCGGGT/CACGGC 1 A/T mis1 ese34Minor allele frequency- C:0.00EU EA WA 414
    rs75120121,2
    		A,C,F,H159428797(+) GTGCCA/GGCCAC 1 -- int18Minor allele frequency- G:0.26EU EA WA NA 778
    About this table

    HapMap Linkage Disequilibrium images for ADAMTS4 (up to first 250kb)

    Disorders & Mutations
    for ADAMTS4

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 603876

    10/11 Novoseek disease relationships for ADAMTS4 gene (see all 11 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 76.62 20 18328163 (3), 11801682 (1), 16099106 (1), 17470431 (1) (see all 11)
    arthritis 54.35 8 11311239 (1), 17487981 (1), 18247274 (1), 10827174 (1) (see all 6)
    chondrosarcoma 43.47 3 11796708 (1), 14701864 (1)
    necrosis 33.90 4 17968946 (1), 16806998 (1), 11520168 (1), 15880812 (1)
    rheumatoid arthritis 32.27 6 11801682 (1), 16099106 (1), 15161923 (1), 14534304 (1)
    glioblastoma 30.24 4 16003758 (3)
    glioma 16.32 2 11217446 (1)
    pathological processes 10.24 1 15334469 (1)
    cancer 3.96 2 19260128 (1), 17355265 (1)
    tumors 3.21 4 17968946 (1), 16806998 (1), 11520168 (1), 15880812 (1)
    About this table

    Human Genome Epidemiology Navigator: ADAMTS4 (2 documents)

    Medical News
    for ADAMTS4

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ADAMTS4

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/140 PubMed articles for ADAMTS4 gene (see all 140 ):

    Search for ADAMTS4

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAMTS4

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9507 HGNC: 220 AceView: ADAMTS4 Ensembl:ENSG00000158859 euGenes: HUgn9507
    ECgene: ADAMTS4 H-InvDB: ADAMTS4

    Other Databases showing ADAMTS4

    (According to HUGE)
    About This Section
    HUGE: KIAA0688

    Specialized Databases showing ADAMTS4

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ADAMTS4

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ADAMTS4

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADAMTS4:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ADAMTS4-related products

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