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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAMTS4 Gene

protein-coding GIFtS: 64
GCID: GC01M161159

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)

Explore 19 diseases affiliated with
ADAMTS4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 4¹ ²		ADAM-TS 4² ³
ADMP-1¹ ² ³		EC 3.4.24.82³ ⁸
ADAMTS-2¹ ²		A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4²
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 4¹ ²		Aggrecanase-1³
KIAA0688¹ ³		Aggrecanase-1³
ADAM-TS4² ³		EC 3.4.24⁸
ADAMTS-4² ³

External Ids:	HGNC: 220¹	Entrez Gene: 9507²	Ensembl: ENSG00000158859⁷	OMIM: 603876⁵	UniProtKB: O75173³

Export aliases for ADAMTS4 gene to outside databases

Previous GC identifers: GC01M158870 GC01M156891 GC01M157937 GC01M158376 GC01M157972 GC01M159426 GC01M132516

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS4:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein

family. Members of the family share several distinct protein modules, including a propeptide region, a

metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of

this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded

by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of

cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests

key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of

glioma. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role

in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of

neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu- -Ala-393' site

Gene Wiki entry for ADAMTS4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAMTS4 gene promoter:
E2F-4 E2F-3a E2F-5 MyoD CUTL1 E2F-2 PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS4 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAMTS4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q31-q32

ADAMTS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M161159: view genomic region (about GC identifiers)

Start:	161,159,538 bp from pter	End:	161,168,846 bp from pter
Size:	9,309 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 4 precursor

Size: 837 amino acids; 90197 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Interacts with SRPX2

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Caution: Has sometimes been referred to as ADAMTS2

Sequence caution: Sequence=BAA31663.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for ADAMTS4:

2RJP (3D)

3B2Z (3D)

Secondary accessions: Q5VTW2 Q6P4Q8 Q6UWA8 Q9UN83

Explore the universe of human proteins at neXtProt for ADAMTS4: NX_O75173

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase¹

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence

C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the

repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose

residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.

Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence

W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75173

4/22 DME Specific Peptides for ADAMTS4 (O75173) (see all 22)

MLHDNSK

DYDADRQ

RYSFFVP

PWGDCSR

ADAMTS4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005090.3

ENSEMBL proteins:

ENSP00000356975 ENSP00000356974

Human Recombinant Protein Products for ADAMTS4:

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	Novus Biologicals ADAMTS4 Proteins Novus Biologicals ADAMTS4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADAMTS4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	14744861

ADAMTS4 for ontologies About GeneDecksing

ADAMTS4 Antibody Products:

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	Uscn Antibodies for ADAMTS4
	ThermoFisher Antibody for ADAMTS4

Assay Products for ADAMTS4:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAMTS4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADAMTS4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAMTS4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000884 Thrombospondin_1_rpt

IPR024079 MetalloPept_cat_dom

IPR010294 ADAM_spacer1

IPR001590 Peptidase_M12B

IPR002870 Peptidase_M12B_N

Graphical View of Domain Structure for InterPro Entry O75173

ProtoNet protein and cluster: O75173

4 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular

matrix

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 1 TSP type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATS4_HUMAN, O75173

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role

in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of

neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu- -Ala-393' site

Catalytic activity: Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu- -Ala-Arg-Gly-Ser-377 in the

interglobular domain of mammalian aggrecan

Induction: By IL1/interleukin-1

Genatlas biochemistry entry for ADAMTS4:

a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 1,with thrombospondin type 1 motif

4,potentially degrading aggrecan in arthritis disease,extracellular matrix protein

Enzyme Numbers (IUBMB): EC 3.4.24.82¹ ² EC 3.4.24²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	14744861
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	18718938
GO:0008233	peptidase activity	TAS	10751421
GO:0008237	metallopeptidase activity	TAS	10356395

ADAMTS4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADAMTS4:

Proliferating cells

7 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Adamts4):

behavior/neurological	mortality/aging	nervous system	no phenotypic analysis	normal
renal/urinary system	skeleton

ADAMTS4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ADAMTS4: Adamts4^tm1Dqp Adamts4^tm1.1Boer Adamts4^tm1.1Lex Adamts4^tm1.1Eam

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS4

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		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS4 (see all 41):
		hsa-miR-345 hsa-miR-596 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-3146 hsa-miR-1914* hsa-miR-485-3p hsa-miR-486-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS4 (see all 4) OriGene shRNA RFP: ADAMTS4 OriGene siRNA: ADAMTS4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTS4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADAMTS4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endochondral Ossification

Endochondral Ossification

1.00

Cell adhesion_ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADAMTS4

Metalloproteases in connective tissue degradation

1 BioSystems Pathway for ADAMTS4

Endochondral Ossification

ADAMTS4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADAMTS4

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/14 Interacting proteins for ADAMTS4 (O75173³ ENSP00000356975⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FURIN	P09958³, ENSP00000268171⁴	I2D: score=2 STRING: ENSP00000268171
SERPINA1	P01009³, ENSP00000348068⁴	I2D: score=2 STRING: ENSP00000348068
FN1	P02751³, ENSP00000346839⁴	I2D: score=1 STRING: ENSP00000346839
MT2A	P02795³, ENSP00000245185⁴	I2D: score=1 STRING: ENSP00000245185
SRPX2	O60687³, ENSP00000362095⁴	I2D: score=1 STRING: ENSP00000362095

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	10356395
GO:0006508	proteolysis	IEA	--

ADAMTS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADAMTS4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ADAMTS4

Browse Tocris compounds for ADAMTS4
7 Novoseek chemical compound relationships for ADAMTS4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	67.3	11	16507336 (1), 11817583 (1), 17208315 (1), 17763444 (1) (see all 6)
chondroitin sulfate	50.3	18	16945513 (7), 10751421 (1), 10998358 (1), 14701864 (1)
glucosamine	36.2	2	16300972 (1)
pge2	32.2	4	19786147 (2), 20133709 (1), 18438860 (1)
tgf beta1	30.9	2	15599946 (1), 15883123 (1)
nitric oxide	8.02	3	16806998 (1), 15922185 (1), 17605605 (1)
heparin	0	1	18156631 (1)

Search CenterWatch for drugs/clinical trials and news about ADAMTS4 / ATS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAMTS4 gene:

NM_005099.4

Unigene Cluster for ADAMTS4:

ADAM metallopeptidase with thrombospondin type 1 motif, 4

Hs.211604 [show with all ESTs]

Unigene Representative Sequence: NM_005099

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367996(uc001fyt.4) ENST00000478394 ENST00000367995(uc001fyu.2)

miRNA Products:		OriGene 3'-UTR Clone: ADAMTS4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS4
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS4 (see all 41):
		hsa-miR-345 hsa-miR-596 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-3146 hsa-miR-1914* hsa-miR-485-3p hsa-miR-486-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS4 3' UTR sequence

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Additional cDNA sequence:

AB014588.1 AF148213.1 AK291573.1 AY358886.1 BC063293.1 DQ364570.1

5 DOTS entries:

DT.40295660 DT.403409 DT.97766329 DT.100707470 DT.92419173

24/33 AceView cDNA sequences (see all 33):

AI678879 AA603151 AL712592 BC030812 AB014588 AY358886 NM_005099 AI682879

BF771897 BM069747 BI602707 BC063293 CD619814 BX503840 BP349742 BQ694677

BG704864 AL603427 AF148213 BP342809 BM069515 AI889705 D45652 CD619811

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS4 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:													-				-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ADAMTS4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAMTS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTGAGCA

About this image

ADAMTS4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADAMTS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAMTS4

SOURCE GeneReport for Unigene cluster: Hs.211604

UniProtKB/Swiss-Prot: ATS4_HUMAN, O75173

Tissue specificity: Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles

SABiosciences Custom PCR Arrays for ADAMTS4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS4 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ADAMTS4⁶	--	63(a)	1 ↔ 1	GL343781.1(132828-144569)
fruit fly (Drosophila melanogaster)	Insecta	CG14869⁶	--	14(a)	1 → many	3R(11267965-11301915)
worm (Caenorhabditis elegans)	Secernentea	mig-17⁶ gon-1⁶	ADAM family mig-17 A disintegrin and metalloproteinase with thrombosp...	14(a) 13(a)	possible ortholog 1 ↔ many	V(11446634-11449228) IV(9935046-9945754)

ENSEMBL Gene Tree for ADAMTS4 (if available)
TreeFam Gene Tree for ADAMTS4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAMTS4 gene

ADAMTS17² ADAMTS18² ADAMTS6² ADAMTS12² ADAMTS20² ADAMTS5² ADAMTS9² ADAMTS16²

ADAMTS10² ADAMTS7² ADAMTS1² ADAMTS19² ADAMTS14² ADAMTS2² ADAMTS15² ADAMTS8²

ADAMTS3²

14 SIMAP similar genes for ADAMTS4 using alignment to 3 protein entries: ATS4_HUMAN (see all proteins):

ADAMTS5 ADAMTS9 ADAMTS15 ADAMTS20 ADAMTS8 ADAMTS1

ADAMTS3 DKFZp686E01144 ADAMTS6 ADAMTS12 ADAMTS16 ADAMTS2

ADAMTS14 ADAMTS7

ADAMTS4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193238424^1,2		--	161159050(+)	`GAGCAA/TTCTAA`	1	--	ds500¹		0	--	--	--	--
rs76868918^1,2	F	--	161159127(+)	`AGACCC/TGCTGG`	1	--	ds500¹		1		WA	118
rs4233366^1,2	C,F,A,H	--	161159147(+)	`CAGTGC/TTCTTT`	1	--	ds500¹		24		NS EA NA CSA WA	2920
rs11583589^1,2	C,A,H	--	161159158(+)	`CTACTG/TTTGTG`	1	--	ds500¹		2		NA	122
rs147638828^1,2		--	161159274(+)	`CAATTC/GTATTT`	1	--	ds500¹		0	--	--	--	--
rs142313268^1,2		--	161159288(+)	`GCCACA/GTGCTT`	1	--	ds500¹		0	--	--	--	--
rs144519251^1,2	C	--	161159411(+)	`CCTGAA/GGATAA`	1	--	ds500¹		0	--	--	--	--
rs36123104^1,2	C,F,H	--	161159435(+)	`GGTTGT/CGGATC`	1	--	ds500¹		18		NS EA NA WA	2342
rs185423435^1,2		--	161159504(+)	`GTAACA/GGCAGC`	1	--	ds500¹		0	--	--	--	--
rs145543139^1,2		--	161159652(+)	`AGGATA/GCAACC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADAMTS4 (161159538 - 161168846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADAMTS4
1 CNV: 6790

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAMTS4 for disorders           About GeneDecksing

OMIM gene information: 603876    OMIM disorders: --

19 diseases for ADAMTS4:    About MalaCards

ehlers-danlos syndrome cerebral artery occlusion myocardial infarction acute myocardial infarction

rheumatoid arthritis chondrosarcoma osteoarthritis multiple sclerosis

arthritis glioblastoma alzheimer's disease cerebritis

neurodegeneration sarcoma cholesterol hypoxia

schizophrenia prostatitis lumbar disc herniation

2 diseases from the University of Copenhagen DISEASES database for ADAMTS4:

Osteoarthritis Ehlers-Danlos syndrome

10/11 Novoseek disease relationships for ADAMTS4 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	77.5	20	18328163 (3), 11801682 (1), 16099106 (1), 17470431 (1) (see all 11)
arthritis	53.6	8	11311239 (1), 17487981 (1), 18247274 (1), 10827174 (1) (see all 6)
chondrosarcoma	41.4	3	11796708 (1), 14701864 (1)
necrosis	33.1	4	17968946 (1), 16806998 (1), 11520168 (1), 15880812 (1)
rheumatoid arthritis	29.7	6	11801682 (1), 16099106 (1), 15161923 (1), 14534304 (1)
glioblastoma	27.2	4	16003758 (3)
glioma	13.5	2	11217446 (1)
pathological processes	7.42	1	15334469 (1)
cancer	3.32	2	19260128 (1), 17355265 (1)
leukemia	0	2	15641077 (1), 16806998 (1)

Human Genome Epidemiology (HuGE) Navigator: ADAMTS4 (2 documents)

Export disorders for ADAMTS4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADAMTS4 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with ADAMTS4)

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world of online information

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. (PubMed id 10827174)^{1, 2, 9} Tortorella M.D.... Arner E.C. (2000)
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. (PubMed id 10356395)^{1, 2, 9} Tortorella M.D.... Arner E.C. (1999)
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. (PubMed id 18718938)^{1, 2} Royer-Zemmour B....Szepetowski P. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. (PubMed id 10094461)^{1, 3} Tang B.L. and Hong W. (1999)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. (PubMed id 15161923)^{1, 9} Hashimoto G....Okada Y. (2004)
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. (PubMed id 19944557)^{1, 9} Zha Y....Cui L. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9507	HGNC: 220	AceView: ADAMTS4	Ensembl:ENSG00000158859	euGenes: HUgn9507
ECgene: ADAMTS4	H-InvDB: ADAMTS4

(According to HUGE)
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HUGE: KIAA0688

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADAMTS4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAMTS4 gene
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Patent Information for ADAMTS4 gene:
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