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Aliases for ADAMTS4 Gene

Aliases for ADAMTS4 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 4 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 4 2 3
  • Aggrecanase-1 3 4
  • EC 3.4.24.82 4 63
  • ADAM-TS 4 3 4
  • ADAM-TS4 3 4
  • ADAMTS-4 3 4
  • ADMP-1 3 4
  • EC 3.4.24 63
  • ADAMTS-2 3
  • KIAA0688 4

External Ids for ADAMTS4 Gene

Previous GeneCards Identifiers for ADAMTS4 Gene

  • GC01M158870
  • GC01M156891
  • GC01M157937
  • GC01M158376
  • GC01M157972
  • GC01M159426
  • GC01M132516

Summaries for ADAMTS4 Gene

Entrez Gene Summary for ADAMTS4 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS4 Gene

ADAMTS4 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 4) is a Protein Coding gene. Diseases associated with ADAMTS4 include osteoarthritis and chondrosarcoma. Among its related pathways are Endochondral Ossification and Degradation of the extracellular matrix. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS4 Gene

  • Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site

Gene Wiki entry for ADAMTS4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS4 Gene

Genomics for ADAMTS4 Gene

Regulatory Elements for ADAMTS4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS4 Gene

Chromosome:
1
Start:
161,184,308 bp from pter
End:
161,199,056 bp from pter
Size:
14,749 bases
Orientation:
Minus strand

Genomic View for ADAMTS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ADAMTS4 Gene

Proteins for ADAMTS4 Gene

  • Protein details for ADAMTS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75173-ATS4_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 4
    Protein Accession:
    O75173
    Secondary Accessions:
    • Q2HYD0
    • Q5VTW2
    • Q6P4Q8
    • Q6UWA8
    • Q9UN83

    Protein attributes for ADAMTS4 Gene

    Size:
    837 amino acids
    Molecular mass:
    90197 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with SRPX2.
    SequenceCaution:
    • Sequence=BAA31663.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAMTS4 Gene

    Alternative splice isoforms for ADAMTS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS4 Gene

Proteomics data for ADAMTS4 Gene at MOPED

Post-translational modifications for ADAMTS4 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase
  • Glycosylation at Asn 68
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAMTS4 Gene

Gene Families for ADAMTS4 Gene

Suggested Antigen Peptide Sequences for ADAMTS4 Gene

Graphical View of Domain Structure for InterPro Entry

O75173

UniProtKB/Swiss-Prot:

ATS4_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with ADAMTS4: view

Function for ADAMTS4 Gene

Molecular function for ADAMTS4 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type),aggrecanase 1,with thrombospondin type 1 motif 4,potentially degrading aggrecan in arthritis disease,extracellular matrix protein
UniProtKB/Swiss-Prot CatalyticActivity:
Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu- -Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan
UniProtKB/Swiss-Prot Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site
UniProtKB/Swiss-Prot Induction:
By IL1/interleukin-1

Enzyme Numbers (IUBMB) for ADAMTS4 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 14744861
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 18718938
GO:0008233 peptidase activity TAS 10751421
GO:0008237 metallopeptidase activity TAS 10356395
genes like me logo Genes that share ontologies with ADAMTS4: view
genes like me logo Genes that share phenotypes with ADAMTS4: view

Animal Models for ADAMTS4 Gene

MGI Knock Outs for ADAMTS4:

Animal Model Products

miRNA for ADAMTS4 Gene

miRTarBase miRNAs that target ADAMTS4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAMTS4 Gene

Localization for ADAMTS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS4 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS4 Gene COMPARTMENTS Subcellular localization image for ADAMTS4 gene
Compartment Confidence
extracellular 4
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADAMTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 14744861
GO:0031012 extracellular matrix IDA 23658023
genes like me logo Genes that share ontologies with ADAMTS4: view

Pathways & Interactions for ADAMTS4 Gene

genes like me logo Genes that share pathways with ADAMTS4: view

Pathways by source for ADAMTS4 Gene

Gene Ontology (GO) - Biological Process for ADAMTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10356395
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with ADAMTS4: view

No data available for SIGNOR curated interactions for ADAMTS4 Gene

Drugs & Compounds for ADAMTS4 Gene

(4) Drugs for ADAMTS4 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tinzaparin Approved Pharma Enzyme, inhibitor 36
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540
Glucosamine Approved Nutra 51

(4) Additional Compounds for ADAMTS4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
9007-28-7
Glycosaminoglycan
pge2
TGF beta1
genes like me logo Genes that share compounds with ADAMTS4: view

Transcripts for ADAMTS4 Gene

mRNA/cDNA for ADAMTS4 Gene

Unigene Clusters for ADAMTS4 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ADAMTS4 Gene

GeneLoc Exon Structure for
ADAMTS4
ECgene alternative splicing isoforms for
ADAMTS4

Expression for ADAMTS4 Gene

mRNA expression in normal human tissues for ADAMTS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS4 Gene

This gene is overexpressed in Ovary (x5.7) and Adipose - Visceral (Omentum) (x5.6).

Protein differential expression in normal tissues from HIPED for ADAMTS4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.5), Pancreatic juice (24.4), and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS4 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS4 Gene Hs.211604

mRNA Expression by UniProt/SwissProt for ADAMTS4 Gene

O75173-ATS4_HUMAN
Tissue specificity: Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium.
genes like me logo Genes that share expression patterns with ADAMTS4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ADAMTS4 Gene

Orthologs for ADAMTS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS4 35
  • 89.25 (n)
  • 91.76 (a)
ADAMTS4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS4 35
  • 87.34 (n)
  • 91.76 (a)
ADAMTS4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts4 35
  • 86.82 (n)
  • 90.38 (a)
Adamts4 16
Adamts4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS4 35
  • 99.72 (n)
  • 99.64 (a)
ADAMTS4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts4 35
  • 86.14 (n)
  • 88.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts4 35
  • 66.32 (n)
  • 68.05 (a)
Species with no ortholog for ADAMTS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAMTS4 Gene

ENSEMBL:
Gene Tree for ADAMTS4 (if available)
TreeFam:
Gene Tree for ADAMTS4 (if available)

Paralogs for ADAMTS4 Gene

genes like me logo Genes that share paralogs with ADAMTS4: view

Variants for ADAMTS4 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3123545 -- 161,194,789(-) catag(G/T)tattt intron-variant
rs3123546 -- 161,194,321(-) TTTTT(A/C)TAGGC intron-variant
rs3134666 -- 161,194,295(-) GGAGC(A/C)TAAGC intron-variant
rs758291395 -- 161,193,275(+) CTGGT(C/T)CTGGG missense, reference
rs758489640 -- 161,191,571(+) TGTGT(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS4 Gene

Variant ID Type Subtype PubMed ID
esv32799 CNV Gain 17666407

Variation tolerance for ADAMTS4 Gene

Residual Variation Intolerance Score: 93.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS4 Gene

HapMap Linkage Disequilibrium report
ADAMTS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS4 Gene

Disorders for ADAMTS4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ADAMTS4 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
osteoarthritis
  • osteoarthrosis
chondrosarcoma
  • chondrosarcoma of bone
bone structure disease
arthritis
  • inflammatory disorder of joint
- elite association

Relevant External Links for ADAMTS4

Genetic Association Database (GAD)
ADAMTS4
Human Genome Epidemiology (HuGE) Navigator
ADAMTS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS4
genes like me logo Genes that share disorders with ADAMTS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS4 Gene

Publications for ADAMTS4 Gene

  1. ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. (PMID: 19944557) Zha Y. … Cui L. (Biomed. Pharmacother. 2010) 23 67
  2. Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis? (PMID: 19277895) Huang K. … Wu L.D. (Mol. Biol. Rep. 2010) 23 67
  3. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. (PMID: 20495569) Yang S. … Chun J.S. (Nat. Med. 2010) 23 67
  4. LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. (PMID: 20133709) Li N. … Yang Z. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  5. Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses. (PMID: 19813262) Fortier L.A. … Mayr K.G. (J. Orthop. Res. 2010) 23 67

Products for ADAMTS4 Gene

Sources for ADAMTS4 Gene

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