Aliases for ADAMTS4 Gene
External Ids for ADAMTS4 Gene
Previous GeneCards Identifiers for ADAMTS4 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS4 Gene
ADAMTS4 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 4) is a Protein Coding gene. Diseases associated with ADAMTS4 include osteoarthritis and chondrosarcoma. Among its related pathways are Endochondral Ossification and Degradation of the extracellular matrix. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS16.
UniProtKB/Swiss-Prot for ADAMTS4 Gene
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site