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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS3 Gene

protein-coding   GIFtS: 62
GCID: GC04M073136

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 31 2     ADAMTS-42
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 31 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 32
Procollagen II Amino Propeptide-Processing Enzyme2 3     Zinc Metalloendopeptidase2
Procollagen II N-Proteinase2 3     EC 3.4.24.-3
ADAM-TS32 3     KIAA03663
ADAMTS-32 3     EC 3.4.248
ADAM-TS 32 3     EC 3.4.24.148
PC II-NP2 3     

External Ids:    HGNC: 2191   Entrez Gene: 95082   Ensembl: ENSG000001561407   OMIM: 6050115   UniProtKB: O150723   

Export aliases for ADAMTS3 gene to outside databases

Previous GC identifers: GC04M073386 GC04M073547 GC04M073612 GC04M073511 GC04M068951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS3 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible
for dermatosparaxis, a genetic defect of connective tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS3 Gene: 
ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif, 3) is a protein-coding gene. Diseases associated with ADAMTS3 include degenerative disc disease, and acute myocardial infarction, and among its related super-pathways are Collagen formation. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072
Function: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III
collagens

Gene Wiki entry for ADAMTS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS3 gene promoter:
         HFH-3   FOXF2   HTF   Arnt   FOXI1   FOXJ2 (long isoform)   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21

ADAMTS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M073136:  view genomic region     (about GC identifiers)

Start:
73,146,686 bp from pter      End:
73,434,516 bp from pter
Size:
287,831 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor  
Size: 1205 amino acids; 135603 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Caution: Has sometimes been referred to as ADAMTS4
Secondary accessions: A1L3U9 Q9BXZ8

Explore the universe of human proteins at neXtProt for ADAMTS3: NX_O15072

Explore proteomics data for ADAMTS3 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15072

  • 4/16 DME Specific Peptides for ADAMTS3 (O15072) (see all 16)
     VCGGDNS  TKYGCRR  SNCDGLAG  EQCRFDFG 

    ADAMTS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS3 Protein Expression
    REFSEQ proteins: NP_055058.2  
    ENSEMBL proteins: 
     ENSP00000286657  
    Reactome Protein details: O15072
    Human Recombinant Protein Products for ADAMTS3: 
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    Cloud-Clone Corp. Proteins for ADAMTS3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS11812023
    GO:0031012colocalizes with extracellular matrix TAS--

    ADAMTS3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS3 
    ADAMTS family

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry O15072

    ProtoNet protein and cluster: O15072

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 4 TSP type-1 domains


    ADAMTS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS3_HUMAN, O15072
    Function: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III
    collagens

         Genatlas biochemistry entry for ADAMTS3:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 3,extracellular
    matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS11812023
    GO:0008201heparin binding IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding NAS11408482
         
    ADAMTS3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAMTS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Extracellular matrix organization0.39
    Collagen formation0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ADAMTS3
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    ADAMTS3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ADAMTS3 (ENSP000002866574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1ENSP000003057144STRING: ENSP00000305714
    TLL1ENSP000000612404STRING: ENSP00000061240
    PCOLCEENSP000002230614STRING: ENSP00000223061
    PCOLCE2ENSP000002959924STRING: ENSP00000295992
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0016485protein processing IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization NAS11812023
    GO:0030574collagen catabolic process NAS11408482

    ADAMTS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTS3 (ATS3)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS3 / ATS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS3 gene: 
    NM_014243.2  

    Unigene Cluster for ADAMTS3:

    ADAM metallopeptidase with thrombospondin type 1 motif, 3
    Hs.590919  [show with all ESTs]
    Unigene Representative Sequence: NM_014243
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286657(uc003hgk.2) ENST00000511274(uc003hgl.3) ENST00000505193

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    Additional mRNA sequence: 

    AB002364.1 AF247668.1 AK295131.1 BC016451.1 BC019707.1 BC130287.1 BC132735.1 

    4 DOTS entries:

    DT.411496  DT.91976875  DT.95293436  DT.99971693 

    24/29 AceView cDNA sequences (see all 29):

    BC016451 NM_014243 BI858020 Z40931 AA398492 AB002364 Z45214 F04104 
    BU689593 BG575152 AF247668 AA402760 AI382295 BI827085 AA329896 N34819 
    F07832 BX108558 BX279756 AL699522 CB161006 BC019707 AU135747 BI092940 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS3 expression in normal human tissues (normalized intensities)      ADAMTS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGAGATA
    ADAMTS3 Expression
    About this image


    ADAMTS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer

    See ADAMTS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS3

    SOURCE GeneReport for Unigene cluster: Hs.590919

    UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072
    Tissue specificity: Found in cartilage and skin

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts31 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 86.25(n)1
    88.52(a)1
      5 (44.32 cM)5
    3301191  NM_001081401.21  NP_001074870.11 
     896738415 
    chicken
    (Gallus gallus)
    Aves ADAMTS31 ADAM metallopeptidase with thrombospondin type 1 motif, more 77.33(n)
    81.66(a)
      428760  XM_426316.3  XP_426316.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS36
    Uncharacterized protein
    76(a)
    1 ↔ 1
    5(147964477-148090243)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5687881 novel protein similar to vertebrate ADAM metallopeptidase more 69.76(n)
    74.16(a)
      568788  XM_692142.5  XP_697234.5 


    ENSEMBL Gene Tree for ADAMTS3 (if available)
    TreeFam Gene Tree for ADAMTS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS3 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS52  ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS102  
    7 SIMAP similar genes for ADAMTS3 using alignment to 2 protein entries:     ATS3_HUMAN (see all proteins):
    ADAMTS14    ADAMTS2    ADAMTS4    ADAMTSL1    ADAMTS1    ADAMTS5
    DKFZp686E01144

    ADAMTS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5757 SNPs in ADAMTS3 are shown (see all 5757)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99945571,2
    C,F,A,H--73146274(+) CCTCCA/GCAGAC 1 -- int122Minor allele frequency- G:0.39NS EA NA WA CSA 2338
    rs1450503081,2
    --73146309(+) CCGCCA/TATTCT 1 -- int10--------
    rs1389118341,2
    --73146330(+) AGGTAC/TAAAAT 1 -- int10--------
    rs1495043681,2
    --73146401(+) ACCATC/TTCCTT 1 -- int10--------
    rs1134109601,2
    C,F--73146450(+) TCTTCG/ATAGTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1445090111,2
    C--73146514(+) TTTTT-/AAAAAA 1 -- int10--------
    rs767859421,2
    F--73146586(+) TACAAG/ATAGCA 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1858350041,2
    --73146616(+) TACTGC/TGTAGG 1 -- int10--------
    rs1164497681,2
    C,F--73146649(+) CCCATC/GATGAA 1 -- int10--------
    rs759748101,2
    C,F--73146684(+) CCAGAT/AGTATA 1 -- spd11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for ADAMTS3 (73146686 - 73396686 bp, first 250kb of ADAMTS3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/37 variations for ADAMTS3 (see all 37):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663516CNV Deletion23128226
    esv2727813CNV Deletion23290073
    esv2727819CNV Deletion23290073
    esv2727817CNV Deletion23290073
    esv2727815CNV Deletion23290073
    esv2727820CNV Deletion23290073
    esv2727821CNV Deletion23290073
    esv1255200CNV Deletion17803354
    esv996163CNV Deletion20482838
    esv2727816CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605011    OMIM disorders: --

    6 diseases for ADAMTS3:    About MalaCards
    degenerative disc disease    acute myocardial infarction    osteoarthritis    myocardial infarction
    atherosclerosis    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for ADAMTS3:
    Osteoarthritis

    ADAMTS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS3
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS3 (1 document)

    Export disorders for ADAMTS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ADAMTS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. (PubMed id 11408482)1, 2, 9 Fernandes R.J.... Apte S.S. (2001)
    2. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (2012)
    3. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (2011)
    4. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    5. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4 Kawahara C....Loughlin J. (2005)
    6. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. (PubMed id 10094461)1, 3 Tang B.L. and Hong W. (1999)
    7. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    8. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 9 Hurskainen T.L.... Apte S.S. (1999)
    9. Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (2012)
    10. Genome-wide association scan of dental caries in the p ermanent dentition. (PubMed id 23259602)1 Wang X....Marazita M.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9508 HGNC: 219 AceView: ADAMTS3 Ensembl:ENSG00000156140 euGenes: HUgn9508
    ECgene: ADAMTS3 H-InvDB: ADAMTS3

    (According to HUGE)
    About This Section
    HUGE: KIAA0366

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS3 gene:
    Search GeneIP for patents involving ADAMTS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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