Aliases for ADAMTS3 Gene
External Ids for ADAMTS3 Gene
Previous GeneCards Identifiers for ADAMTS3 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS3 Gene
ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 3) is a Protein Coding gene. Diseases associated with ADAMTS3 include bone deterioration disease and bone structure disease. Among its related pathways are Degradation of the extracellular matrix and Transport to the Golgi and subsequent modification. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS16.
UniProtKB/Swiss-Prot for ADAMTS3 Gene
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens