Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAMTS3 Gene

protein-coding GIFtS: 61
GCID: GC04M073136

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)

Explore 3 diseases affiliated with
ADAMTS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 3¹ ²		ADAM-TS 3² ³
ADAMTS-4¹ ²		PC II-NP² ³
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 3¹ ²		A Disintegrin And Metalloproteinase With Thrombospondin Motifs 3²
KIAA0366¹ ³		Zinc Metalloendopeptidase²
Procollagen II Amino Propeptide-Processing Enzyme² ³		EC 3.4.24.-³
Procollagen II N-Proteinase² ³		EC 3.4.24⁸
ADAM-TS3² ³		EC 3.4.24.14⁸
ADAMTS-3² ³

External Ids:	HGNC: 219¹	Entrez Gene: 9508²	Ensembl: ENSG00000156140⁷	OMIM: 605011⁵	UniProtKB: O15072³

Export aliases for ADAMTS3 gene to outside databases

Previous GC identifers: GC04M073386 GC04M073547 GC04M073612 GC04M073511 GC04M068951

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS3:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein

family. Members of the family share several distinct protein modules, including a propeptide region, a

metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of

this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded

by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for

dermatosparaxis, a genetic defect of connective tissues. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072

Function: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III

collagens

Gene Wiki entry for ADAMTS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAMTS3 gene promoter:
HFH-3 FOXF2 HTF Arnt FOXI1 FOXJ2 (long isoform) FOXO1a FOXJ2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS3 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAMTS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q21

ADAMTS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS3 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M073136: view genomic region (about GC identifiers)

Start:	73,146,686 bp from pter	End:	73,434,516 bp from pter
Size:	287,831 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor

Size: 1205 amino acids; 135603 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Caution: Has sometimes been referred to as ADAMTS4

Secondary accessions: A1L3U9 Q9BXZ8

Explore the universe of human proteins at neXtProt for ADAMTS3: NX_O15072

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence

C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the

repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose

residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.

Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence

W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15072

4/16 DME Specific Peptides for ADAMTS3 (O15072) (see all 16)

VCGGDNS

TKYGCRR

SNCDGLAG

EQCRFDFG

ADAMTS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055058.2

ENSEMBL proteins:

ENSP00000286657

Reactome Protein details: O15072
Human Recombinant Protein Products for ADAMTS3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ADAMTS3 OriGene Protein Over-expression Lysate: ADAMTS3 OriGene Custom Protein Services for ADAMTS3
	GenScript Custom Purified and Recombinant Proteins Services for ADAMTS3
	Novus Biologicals ADAMTS3 Protein Novus Biologicals ADAMTS3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADAMTS3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	NAS	11812023
GO:0031012	colocalizes with extracellular matrix	TAS	--

ADAMTS3 for ontologies About GeneDecksing

ADAMTS3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for ADAMTS3
	OriGene Antibodies: ADAMTS3 OriGene Custom Antibody Services for ADAMTS3
	GenScript Custom Superior Antibodies Services for ADAMTS3
	Novus Biologicals ADAMTS3 Antibodies
	Abcam antibodies for ADAMTS3
	Uscn Antibodies for ADAMTS3
	ThermoFisher Antibodies for ADAMTS3

Assay Products for ADAMTS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAMTS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADAMTS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAMTS3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000884 Thrombospondin_1_rpt

IPR024079 MetalloPept_cat_dom

IPR010294 ADAM_spacer1

IPR010909 PLAC

IPR001590 Peptidase_M12B

Graphical View of Domain Structure for InterPro Entry O15072

ProtoNet protein and cluster: O15072

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular

matrix

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 1 PLAC domain

Similarity: Contains 4 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATS3_HUMAN, O15072

Function: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III

collagens

Genatlas biochemistry entry for ADAMTS3:

a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 3,extracellular matrix

protein

Enzyme Numbers (IUBMB): EC 3.4.24.-¹ EC 3.4.24.14² EC 3.4.24²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	NAS	11812023
GO:0008201	heparin binding	IEA	--
GO:0008233	peptidase activity	--	--
GO:0008270	zinc ion binding	NAS	11408482

ADAMTS3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS3

miRNA Products:		OriGene 3'-UTR Clone: ADAMTS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS3
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS3 (see all 29):
		hsa-miR-142-3p hsa-miR-30c hsa-miR-495 hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-767-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS3 (see all 7) OriGene shRNA RFP: ADAMTS3 OriGene siRNA: ADAMTS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTS3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADAMTS3
			Sirion Biotech Customized adenovirus for overexpression of ADAMTS3 Sirion Biotech Customized adenovirus for potent knockdown of ADAMTS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADAMTS3 (NM_014243)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADAMTS3
		Search LifeMap BioReagents cell lines for ADAMTS3
		Sirion Biotech Customized stable knockdown cell line services for ADAMTS3 Sirion Biotech Customized inducible knockdown cell line services for ADAMTS3 Sirion Biotech Customized stable overexpressing cell line services for ADAMTS3 Sirion Biotech Customized inducible overexpressing cell line services for ADAMTS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Collagen biosynthesis and modifying enzymes	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ADAMTS3

	Extracellular matrix organization
	Collagen biosynthesis and modifying enzymes
	Collagen formation

ADAMTS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADAMTS3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for ADAMTS3 (ENSP00000286657⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP1	ENSP00000305714⁴	STRING: ENSP00000305714
TLL1	ENSP00000061240⁴	STRING: ENSP00000061240
PCOLCE	ENSP00000223061⁴	STRING: ENSP00000223061
PCOLCE2	ENSP00000295992⁴	STRING: ENSP00000295992

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0016485	protein processing	IEA	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030199	collagen fibril organization	NAS	11812023
GO:0030574	collagen catabolic process	NAS	11408482

ADAMTS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAMTS3
Search CenterWatch for drugs/clinical trials and news about ADAMTS3 / ATS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAMTS3 gene:

NM_014243.2

Unigene Cluster for ADAMTS3:

ADAM metallopeptidase with thrombospondin type 1 motif, 3

Hs.590919 [show with all ESTs]

Unigene Representative Sequence: NM_014243

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000286657(uc003hgk.2) ENST00000511274(uc003hgl.3) ENST00000505193

miRNA Products:		OriGene 3'-UTR Clone: ADAMTS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS3
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS3 (see all 29):
		hsa-miR-142-3p hsa-miR-30c hsa-miR-495 hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-767-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS3 (see all 7) OriGene shRNA RFP: ADAMTS3 OriGene siRNA: ADAMTS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADAMTS3 (NM_014243)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAMTS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS3

Additional cDNA sequence:

AB002364.1 AF247668.1 AK295131.1 BC016451.1 BC019707.1 BC130287.1 BC132735.1

4 DOTS entries:

DT.411496 DT.91976875 DT.95293436 DT.99971693

24/29 AceView cDNA sequences (see all 29):

BC016451 F04104 Z45214 BU689593 Z40931 AB002364 AA398492 BI858020

NM_014243 CB161006 N34819 AA329896 BG575152 BX108558 AI382295 BC019707

AF247668 F07832 AA402760 BI827085 BX279756 AU135747 AL699522 BF969826

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAMTS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGGAGATA

About this image

ADAMTS3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Bone, Cartilage

Photoreceptors, Retina

Kidney

Afferent Arteriole

Juxtaglomerular Cells

Kidney, Smooth Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See ADAMTS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAMTS3

SOURCE GeneReport for Unigene cluster: Hs.590919

UniProtKB/Swiss-Prot: ATS3_HUMAN, O15072

Tissue specificity: Found in cartilage and skin

SABiosciences Custom PCR Arrays for ADAMTS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAMTS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS3 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADAMTS3¹	ADAM metallopeptidase with thrombospondin type 1 motif, more	77.33(n) 81.66(a)		428760 XM_426316.3 XP_426316.3
lizard (Anolis carolinensis)	Reptilia	ADAMTS3⁶ --	--	76(a) 23(a)	1 ↔ 1 possible ortholog	5(147967526-148090243) 2(10454625-10471737)
zebrafish (Danio rerio)	Actinopterygii	LOC568788¹	novel protein similar to vertebrate ADAM metallopeptidase more	69.76(n) 74.16(a)		568788 XM_692142.5 XP_697234.5
honey bee (Apis mellifera)	Insecta	--	--	24(a)	1 → many	Group16.4(41440-51250)

ENSEMBL Gene Tree for ADAMTS3 (if available)
TreeFam Gene Tree for ADAMTS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAMTS3 gene

ADAMTS17² ADAMTS7² ADAMTS1² ADAMTS18² ADAMTS6² ADAMTS19² ADAMTS12² ADAMTS14²

ADAMTS2² ADAMTS20² ADAMTS5² ADAMTS4² ADAMTS15² ADAMTS16² ADAMTS9² ADAMTS8²

ADAMTS10²

11 SIMAP similar genes for ADAMTS3 using alignment to 2 protein entries: ATS3_HUMAN (see all proteins):

ADAMTS14 ADAMTS2 ADAMTS4 ADAMTSL1 ADAMTS1 ADAMTS5

DKFZp686E01144 ADAMTS13 ADAMTS18 ADAMTS6 ADAMTS8

ADAMTS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9994557^1,2	C,F,A,H	--	73146274(+)	`CCTCCA/GCAGAC`	1	--	int¹		22		NS EA NA WA CSA	2338
rs145050308^1,2		--	73146309(+)	`CCGCCA/TATTCT`	1	--	int¹		0	--	--	--	--
rs138911834^1,2		--	73146330(+)	`AGGTAC/TAAAAT`	1	--	int¹		0	--	--	--	--
rs149504368^1,2		--	73146401(+)	`ACCATC/TTCCTT`	1	--	int¹		0	--	--	--	--
rs113410960^1,2	C	--	73146450(+)	`TCTTCG/ATAGTT`	1	--	int¹		1		NA	2
rs144509011^1,2	C	--	73146514(+)	`TTTTT-/AAAAAA`	1	--	int¹		0	--	--	--	--
rs76785942^1,2	F	--	73146586(+)	`TACAAG/ATAGCA`	1	--	int¹		1		WA	118
rs185835004^1,2		--	73146616(+)	`TACTGC/TGTAGG`	1	--	int¹		0	--	--	--	--
rs116449768^1,2	C	--	73146649(+)	`CCCATC/GATGAA`	1	--	int¹		0	--	--	--	--
rs75974810^1,2	F	--	73146684(+)	`CCAGAT/AGTATA`	1	--	spd¹		1		WA	118

HapMap Linkage Disequilibrium report for ADAMTS3 (73146686 - 73396686 bp, first 250kb of ADAMTS3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ADAMTS3
6 CNVs: 59212 36296 63859 92196 38567 2530
3 Indels: 46687 59211 41337

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS3

DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAMTS3 for disorders           About GeneDecksing

OMIM gene information: 605011    OMIM disorders: --

3 diseases for ADAMTS3:    About MalaCards

degenerative disc disease osteoarthritis schizophrenia

1 disease from the University of Copenhagen DISEASES database for ADAMTS3:

Osteoarthritis

Genetic Association Database (GAD): ADAMTS3
Human Genome Epidemiology (HuGE) Navigator: ADAMTS3 (1 document)

Export disorders for ADAMTS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAMTS3 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with ADAMTS3)

Utopia: connect your pdf to the dynamic
world of online information

Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. (PubMed id 11408482)^{1, 2, 9} Fernandes R.J.... Apte S.S. (2001)
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)^{1, 4} Kawahara C....Loughlin J. (2005)
ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. (PubMed id 10094461)^{1, 3} Tang B.L. and Hong W. (1999)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)^{1, 9} Hurskainen T.L.... Apte S.S. (1999)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)¹ Kettunen J....Ripatti S. (2012)
Expression of ADAMTS-2, -3, -13, and -14 in culprit co ronary lesions in patients with acute myocardial infarction or stable angina. (PubMed id 22205175)¹ Lee C.W....Park S.J. (2012)
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)¹ Murea M....Freedman B.I. (2011)
Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)¹ Xu B....Karayiorgou M. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9508	HGNC: 219	AceView: ADAMTS3	Ensembl:ENSG00000156140	euGenes: HUgn9508
ECgene: ADAMTS3	H-InvDB: ADAMTS3

(According to HUGE)
About This Section

HUGE: KIAA0366

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADAMTS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAMTS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADAMTS3 gene:
Search GeneIP for patents involving ADAMTS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for ADAMTS3 (ADAMTS3)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ADAMTS3		OriGene shRNA RFP for ADAMTS3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS3
	OriGene Protein Over-expression Lysate for ADAMTS3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ADAMTS3		OriGene 3'-UTR Clone for ADAMTS3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ADAMTS3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADAMTS3		OriGene Custom Protein Services for ADAMTS3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS3

	GenScript Custom Purified and Recombinant Proteins Services for ADAMTS3		GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS3
	GenScript Custom Assay Services for ADAMTS3		GenScript Custom Superior Antibodies Services for ADAMTS3
	GenScript Custom overexpressing Cell Line Services for ADAMTS3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ADAMTS3 promoter
	Search Chromatin IP Primers for ADAMTS3
	RT² qPCR Primer Assay in human, mouse, rat ADAMTS3
	GNC Network for ADAMTS3
	SABiosciences Custom PCR Arrays for ADAMTS3

Search Tocris compounds for ADAMTS3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADAMTS3 antibodies
	ADAMTS3 proteins
	ADAMTS3 lysates

	Antibodies for ADAMTS3
	See all of Abcam's Antibodies, Kits and Proteins for ADAMTS3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ADAMTS3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ADAMTS3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS3

	SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS3
	SwitchGear Promoter luciferase reporter plasmids for ADAMTS3

ThermoFisher Antibodies for ADAMTS3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS3

Sirion Biotech Customized:

	stable knockdown cell line services for ADAMTS3
	inducible knockdown cell line services for ADAMTS3
	design and validation of potent shRNA sequences against ADAMTS3
	adenovirus for potent knockdown of ADAMTS3
	adenovirus for overexpression of ADAMTS3
	stable overexpressing cell line services for ADAMTS3
	inducible overexpressing cell line services for ADAMTS3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADAMTS3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ADAMTS3 Gene

ADAM metallopeptidase with thrombospondin type 1 motif,...

Aliases
for ADAMTS3 gene

Summaries
for ADAMTS3 gene

Genomic Views
for ADAMTS3 gene

Proteins
for ADAMTS3 gene

Protein Domains /
Families
for ADAMTS3 gene

Function
for ADAMTS3 gene

Pathways & Interactions
for ADAMTS3 gene

Drugs & Compounds
for ADAMTS3 gene

Transcripts
for ADAMTS3 gene

Expression
for ADAMTS3 gene

Orthologs
for ADAMTS3 gene

Paralogs
for ADAMTS3 gene

Genomic Variants
for ADAMTS3 gene

Disorders / Diseases
for ADAMTS3 gene

Publications
for ADAMTS3 gene

External Searches for ADAMTS3 gene

Genome Databases showing ADAMTS3 gene

Other Databases showing ADAMTS3 gene

Specialized Databases showing ADAMTS3 gene

Intellectual Property
for ADAMTS3 gene

Products
for ADAMTS3 gene

View Random Gene

Advanced Search

Export list of displayed genes

ADAMTS3 Gene

ADAM metallopeptidase with thrombospondin type 1 motif,...

Aliasesfor ADAMTS3 gene

Summariesfor ADAMTS3 gene

Genomic Viewsfor ADAMTS3 gene

Proteinsfor ADAMTS3 gene

Protein Domains /Familiesfor ADAMTS3 gene

Functionfor ADAMTS3 gene

Pathways & Interactionsfor ADAMTS3 gene

Drugs & Compoundsfor ADAMTS3 gene

Transcriptsfor ADAMTS3 gene

Expression for ADAMTS3 gene

Orthologsfor ADAMTS3 gene

Paralogsfor ADAMTS3 gene

Genomic Variantsfor ADAMTS3 gene

Disorders / Diseasesfor ADAMTS3 gene

Publicationsfor ADAMTS3 gene

External Searches for ADAMTS3 gene

Genome Databases showing ADAMTS3 gene

Other Databases showing ADAMTS3 gene

Specialized Databases showing ADAMTS3 gene

Intellectual Propertyfor ADAMTS3 gene

Productsfor ADAMTS3 gene

View Random Gene

Aliases
for ADAMTS3 gene

Summaries
for ADAMTS3 gene

Genomic Views
for ADAMTS3 gene

Proteins
for ADAMTS3 gene

Protein Domains /
Families
for ADAMTS3 gene

Function
for ADAMTS3 gene

Pathways & Interactions
for ADAMTS3 gene

Drugs & Compounds
for ADAMTS3 gene

Transcripts
for ADAMTS3 gene

Expression
for ADAMTS3 gene

Orthologs
for ADAMTS3 gene

Paralogs
for ADAMTS3 gene

Genomic Variants
for ADAMTS3 gene

Disorders / Diseases
for ADAMTS3 gene

Publications
for ADAMTS3 gene

Intellectual Property
for ADAMTS3 gene

Products
for ADAMTS3 gene