Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAMTS3 Gene

Aliases for ADAMTS3 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 3 2 3
  • Procollagen II Amino Propeptide-Processing Enzyme 3 4
  • Procollagen II N-Proteinase 3 4
  • ADAM-TS 3 3 4
  • ADAMTS-3 3 4
  • PC II-NP 3 4
  • ADAM-TS3 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 3 3
  • Zinc Metalloendopeptidase 3
  • EC 3.4.24.14 61
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • ADAMTS-4 3
  • KIAA0366 4

External Ids for ADAMTS3 Gene

Previous GeneCards Identifiers for ADAMTS3 Gene

  • GC04M073136
  • GC04M073386
  • GC04M073547
  • GC04M073612
  • GC04M073511
  • GC04M068951

Summaries for ADAMTS3 Gene

Entrez Gene Summary for ADAMTS3 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS3 Gene

ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and HIV Life Cycle. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS2.

UniProtKB/Swiss-Prot for ADAMTS3 Gene

  • Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Gene Wiki entry for ADAMTS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS3 Gene

Genomics for ADAMTS3 Gene

Regulatory Elements for ADAMTS3 Gene

Enhancers for ADAMTS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F072566 1.1 ENCODE 7 +0.8 798 3.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 CBX5 KLF13 ZNF263 ADAMTS3 ENSG00000250877
GH04F073245 1.2 Ensembl ENCODE 5.1 -676.5 -676453 1.5 SMARCE1 ZNF680 CBX3 ARNT MTA2 TAL1 DPF2 ARID1B NCOR1 SMARCA4 ADAMTS3 LOC102724832 GC04P073141
GH04F072896 0.5 ENCODE 5 -327.3 -327338 1.4 ESRRA HLF CEBPB CEBPG PPARG NR2F2 JUND ATF3 IKZF1 CEBPA ADAMTS3 GC04M072932 PIR44130 GC04P072808
GH04F072846 1 Ensembl ENCODE 4.8 -277.3 -277287 0.5 HDAC1 LEF1 PKNOX1 CBX3 TAL1 TEAD4 BACH1 FOXK2 NCOR1 PRDM10 ADAMTS3 GC04P072808 GC04M072932 PIR44130
GH04F072899 0.4 ENCODE 4.3 -330.9 -330868 2.2 SOX13 SOX5 TEAD1 CEBPB CEBPG TEAD3 GATA3 SMARCA4 POLR2A IKZF1 ADAMTS3 PIR44130 GC04M072932 GC04P072808
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAMTS3 on UCSC Golden Path with GeneCards custom track

Promoters for ADAMTS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001242660 786 2401 PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 CBX5 ZNF263 SP3 REST

Genomic Location for ADAMTS3 Gene

Chromosome:
4
Start:
72,280,969 bp from pter
End:
72,569,386 bp from pter
Size:
288,418 bases
Orientation:
Minus strand

Genomic View for ADAMTS3 Gene

Genes around ADAMTS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS3 Gene

Proteins for ADAMTS3 Gene

  • Protein details for ADAMTS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15072-ATS3_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 3
    Protein Accession:
    O15072
    Secondary Accessions:
    • A1L3U9
    • Q9BXZ8

    Protein attributes for ADAMTS3 Gene

    Size:
    1205 amino acids
    Molecular mass:
    135603 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS3 Gene

Post-translational modifications for ADAMTS3 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 83, Asn 119, Asn 242, Asn 345, Asn 475, Asn 814, Asn 942, Ser 1088, Thr 1146, and Ser 1149
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ADAMTS3

Domains & Families for ADAMTS3 Gene

Gene Families for ADAMTS3 Gene

Suggested Antigen Peptide Sequences for ADAMTS3 Gene

Graphical View of Domain Structure for InterPro Entry

O15072

UniProtKB/Swiss-Prot:

ATS3_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 4 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS3: view

Function for ADAMTS3 Gene

Molecular function for ADAMTS3 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 3,extracellular matrix protein
UniProtKB/Swiss-Prot Function:
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Enzyme Numbers (IUBMB) for ADAMTS3 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 24552833
GO:0004222 metalloendopeptidase activity IEA,TAS --
GO:0005515 protein binding IPI 24552833
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS3: view
genes like me logo Genes that share phenotypes with ADAMTS3: view

Animal Models for ADAMTS3 Gene

MGI Knock Outs for ADAMTS3:

Animal Model Products

miRNA for ADAMTS3 Gene

miRTarBase miRNAs that target ADAMTS3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAMTS3 Gene

Localization for ADAMTS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS3 Gene COMPARTMENTS Subcellular localization image for ADAMTS3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix NAS 11812023
GO:0005615 extracellular space IDA 24552833
GO:0031012 colocalizes_with extracellular matrix TAS 22261194
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with ADAMTS3: view

Pathways & Interactions for ADAMTS3 Gene

genes like me logo Genes that share pathways with ADAMTS3: view

Interacting Proteins for ADAMTS3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286657%0d%0a9606.ENSP00000295992%0d%0a9606.ENSP00000223061%0d%0a9606.ENSP00000305714%0d%0a9606.ENSP00000061240%0d%0a
Selected Interacting proteins: O15072-ATS3_HUMAN ENSP00000286657 for ADAMTS3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADAMTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010573 vascular endothelial growth factor production IDA 24552833
GO:0016485 protein processing IDA 11408482
GO:0030199 collagen fibril organization IC,NAS 11812023
GO:0030574 collagen catabolic process NAS 11408482
genes like me logo Genes that share ontologies with ADAMTS3: view

No data available for SIGNOR curated interactions for ADAMTS3 Gene

Transcripts for ADAMTS3 Gene

Unigene Clusters for ADAMTS3 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS3 Gene

No ASD Table

Relevant External Links for ADAMTS3 Gene

GeneLoc Exon Structure for
ADAMTS3
ECgene alternative splicing isoforms for
ADAMTS3

Expression for ADAMTS3 Gene

mRNA expression in normal human tissues for ADAMTS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS3 Gene

This gene is overexpressed in Fallopian Tube (x4.2).

Protein differential expression in normal tissues from HIPED for ADAMTS3 Gene

This gene is overexpressed in Spinal cord (38.0) and CD4 Tcells (28.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADAMTS3 Gene:

ADAMTS3

SOURCE GeneReport for Unigene cluster for ADAMTS3 Gene:

Hs.590919

mRNA Expression by UniProt/SwissProt for ADAMTS3 Gene:

O15072-ATS3_HUMAN
Tissue specificity: Found in cartilage and skin.
genes like me logo Genes that share expression patterns with ADAMTS3: view

Primer Products

No data available for Protein tissue co-expression partners for ADAMTS3 Gene

Orthologs for ADAMTS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS3 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ADAMTS3 34 35
  • 91.65 (n)
dog
(Canis familiaris)
Mammalia ADAMTS3 34
  • 89.59 (n)
rat
(Rattus norvegicus)
Mammalia Adamts3 34
  • 87.96 (n)
mouse
(Mus musculus)
Mammalia Adamts3 34 16 35
  • 85.05 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS3 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS3 34 35
  • 77.3 (n)
lizard
(Anolis carolinensis)
Reptilia ADAMTS3 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts3 34
  • 73.57 (n)
zebrafish
(Danio rerio)
Actinopterygii adamts3 35
  • 77 (a)
OneToOne
LOC568788 34
  • 71.97 (n)
worm
(Caenorhabditis elegans)
Secernentea C37C3.6a 36
  • 34 (a)
C37C3.6b 36
  • 34 (a)
T19D2.1 36
  • 26 (a)
F08C6.1 36
  • 24 (a)
Species where no ortholog for ADAMTS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS3 Gene

ENSEMBL:
Gene Tree for ADAMTS3 (if available)
TreeFam:
Gene Tree for ADAMTS3 (if available)

Paralogs for ADAMTS3 Gene

(7) SIMAP similar genes for ADAMTS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAMTS3: view

Variants for ADAMTS3 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs193921131 Uncertain significance 72,568,699(-) CTGAT(G/T)GACAA upstream-variant-2KB, reference, stop-gained
rs10001463 -- 72,417,688(+) CATTT(G/T)GGGAC intron-variant
rs10002579 -- 72,462,785(+) CAATG(C/T)GTTTG intron-variant
rs10008122 -- 72,389,903(+) ACTTA(C/T)ATTTT intron-variant
rs10009097 -- 72,384,896(+) gggtg(C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS3 Gene

Variant ID Type Subtype PubMed ID
dgv2825n106 CNV insertion 24896259
dgv2826n106 CNV deletion 24896259
esv1024654 CNV insertion 17803354
esv1255200 CNV deletion 17803354
esv1266268 CNV insertion 17803354
esv1789836 CNV insertion 17803354
esv1992065 CNV deletion 18987734
esv2079277 CNV deletion 18987734
esv22832 CNV gain+loss 19812545
esv2663516 CNV deletion 23128226
esv2667909 CNV deletion 23128226
esv2727811 CNV deletion 23290073
esv2727812 CNV deletion 23290073
esv2727813 CNV deletion 23290073
esv2727814 CNV deletion 23290073
esv2727815 CNV deletion 23290073
esv2727816 CNV deletion 23290073
esv2727817 CNV deletion 23290073
esv2727819 CNV deletion 23290073
esv2727820 CNV deletion 23290073
esv2727821 CNV deletion 23290073
esv2759260 CNV loss 17122850
esv2760818 CNV loss 21179565
esv3052821 CNV deletion 24192839
esv3416833 CNV insertion 20981092
esv3600969 CNV loss 21293372
esv3600971 CNV loss 21293372
esv4638 CNV loss 18987735
esv996163 CNV deletion 20482838
nsv1011153 CNV loss 25217958
nsv1073344 CNV deletion 25765185
nsv1073773 CNV deletion 25765185
nsv1076862 CNV insertion 25765185
nsv1129248 CNV insertion 24896259
nsv1132934 CNV insertion 24896259
nsv1142399 CNV tandem duplication 24896259
nsv1145858 CNV insertion 26484159
nsv1147304 CNV deletion 26484159
nsv1150252 CNV insertion 26484159
nsv289840 CNV deletion 16902084
nsv291650 CNV insertion 16902084
nsv4385 CNV deletion 18451855
nsv441889 CNV loss 18776908
nsv476267 CNV novel sequence insertion 20440878
nsv477796 CNV novel sequence insertion 20440878
nsv514226 CNV loss 21397061
nsv594656 CNV gain 21841781
nsv819500 CNV loss 19587683
nsv819816 CNV gain 19587683
nsv829968 CNV gain 17160897
nsv829969 CNV gain 17160897
nsv955686 CNV deletion 24416366
nsv964341 CNV deletion 23825009

Variation tolerance for ADAMTS3 Gene

Residual Variation Intolerance Score: 3.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS3 Gene

Human Gene Mutation Database (HGMD)
ADAMTS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAMTS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS3 Gene

Disorders for ADAMTS3 Gene

Relevant External Links for ADAMTS3

Genetic Association Database (GAD)
ADAMTS3
Human Genome Epidemiology (HuGE) Navigator
ADAMTS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS3

No disorders were found for ADAMTS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS3 Gene

Publications for ADAMTS3 Gene

  1. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. (PMID: 11408482) Fernandes R.J. … Apte S.S. (J. Biol. Chem. 2001) 3 4 22 64
  2. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PMID: 22286219) Kettunen J. … Ripatti S. (Nat. Genet. 2012) 3 46 64
  3. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 46 64
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  5. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PMID: 15708897) Kawahara C. … Loughlin J. (Ann. Rheum. Dis. 2005) 3 46 64

Products for ADAMTS3 Gene

Sources for ADAMTS3 Gene

Content
Loading form....