Aliases for ADAMTS3 Gene
External Ids for ADAMTS3 Gene
Previous GeneCards Identifiers for ADAMTS3 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS3 Gene
ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) is a Protein Coding gene. Diseases associated with ADAMTS3 include bone deterioration disease and degenerative disc disease. Among its related pathways are Collagen biosynthesis and modifying enzymes and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.
UniProtKB/Swiss-Prot for ADAMTS3 Gene
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.