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Aliases for ADAMTS3 Gene

Aliases for ADAMTS3 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 3 2 3
  • Procollagen II Amino Propeptide-Processing Enzyme 3 4
  • Procollagen II N-Proteinase 3 4
  • ADAM-TS 3 3 4
  • ADAMTS-3 3 4
  • PC II-NP 3 4
  • ADAM-TS3 3 4
  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 3 3
  • Zinc Metalloendopeptidase 3
  • EC 3.4.24.14 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • ADAMTS-4 3
  • KIAA0366 4

External Ids for ADAMTS3 Gene

Previous GeneCards Identifiers for ADAMTS3 Gene

  • GC04M073136
  • GC04M073386
  • GC04M073547
  • GC04M073612
  • GC04M073511
  • GC04M068951

Summaries for ADAMTS3 Gene

Entrez Gene Summary for ADAMTS3 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS3 Gene

ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) is a Protein Coding gene. Diseases associated with ADAMTS3 include bone deterioration disease and degenerative disc disease. Among its related pathways are Degradation of the extracellular matrix and O-linked glycosylation. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.

UniProtKB/Swiss-Prot for ADAMTS3 Gene

  • Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Gene Wiki entry for ADAMTS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS3 Gene

Genomics for ADAMTS3 Gene

Regulatory Elements for ADAMTS3 Gene

Promoters for ADAMTS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS3 Gene

Chromosome:
4
Start:
72,280,969 bp from pter
End:
72,568,799 bp from pter
Size:
287,831 bases
Orientation:
Minus strand

Genomic View for ADAMTS3 Gene

Genes around ADAMTS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS3 Gene

Proteins for ADAMTS3 Gene

  • Protein details for ADAMTS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15072-ATS3_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 3
    Protein Accession:
    O15072
    Secondary Accessions:
    • A1L3U9
    • Q9BXZ8

    Protein attributes for ADAMTS3 Gene

    Size:
    1205 amino acids
    Molecular mass:
    135603 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS3 Gene

Proteomics data for ADAMTS3 Gene at MOPED

Post-translational modifications for ADAMTS3 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 83, Asn 119, Asn 242, Asn 345, Asn 475, Asn 814, Asn 942, Ser 1088, Thr 1146, and Ser 1149
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAMTS3 Gene

Gene Families for ADAMTS3 Gene

Suggested Antigen Peptide Sequences for ADAMTS3 Gene

Graphical View of Domain Structure for InterPro Entry

O15072

UniProtKB/Swiss-Prot:

ATS3_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 4 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS3: view

Function for ADAMTS3 Gene

Molecular function for ADAMTS3 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 3,extracellular matrix protein
UniProtKB/Swiss-Prot Function:
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Enzyme Numbers (IUBMB) for ADAMTS3 Gene

genes like me logo Genes that share phenotypes with ADAMTS3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS3

miRNA for ADAMTS3 Gene

miRTarBase miRNAs that target ADAMTS3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS3 Gene

Localization for ADAMTS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS3 Gene COMPARTMENTS Subcellular localization image for ADAMTS3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031012 colocalizes_with extracellular matrix IEA,TAS 22261194
genes like me logo Genes that share ontologies with ADAMTS3: view

Pathways & Interactions for ADAMTS3 Gene

genes like me logo Genes that share pathways with ADAMTS3: view

Interacting Proteins for ADAMTS3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286657%0d%0a9606.ENSP00000061240%0d%0a9606.ENSP00000223061%0d%0a9606.ENSP00000295992%0d%0a9606.ENSP00000305714%0d%0a
Selected Interacting proteins: ENSP00000286657 for ADAMTS3 Gene via STRING

Gene Ontology (GO) - Biological Process for ADAMTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010573 vascular endothelial growth factor production IDA 24552833
GO:0030198 extracellular matrix organization TAS --
GO:0030199 collagen fibril organization NAS 11812023
GO:0032964 collagen biosynthetic process IDA 11408482
GO:0043206 extracellular fibril organization IC 11408482
genes like me logo Genes that share ontologies with ADAMTS3: view

No data available for SIGNOR curated interactions for ADAMTS3 Gene

Drugs & Compounds for ADAMTS3 Gene

No Compound Related Data Available

Transcripts for ADAMTS3 Gene

Unigene Clusters for ADAMTS3 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS3 Gene

No ASD Table

Relevant External Links for ADAMTS3 Gene

GeneLoc Exon Structure for
ADAMTS3
ECgene alternative splicing isoforms for
ADAMTS3

Expression for ADAMTS3 Gene

mRNA expression in normal human tissues for ADAMTS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS3 Gene

This gene is overexpressed in Fallopian Tube (x4.2).

Protein differential expression in normal tissues from HIPED for ADAMTS3 Gene

This gene is overexpressed in Spinal cord (38.0) and CD4 Tcells (28.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS3 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS3 Gene Hs.590919

mRNA Expression by UniProt/SwissProt for ADAMTS3 Gene

O15072-ATS3_HUMAN
Tissue specificity: Found in cartilage and skin.
genes like me logo Genes that share expression patterns with ADAMTS3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ADAMTS3 Gene

Orthologs for ADAMTS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS3 35
  • 91.65 (n)
  • 93.59 (a)
ADAMTS3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS3 35
  • 89.59 (n)
  • 89.01 (a)
mouse
(Mus musculus)
Mammalia Adamts3 35
  • 85.05 (n)
  • 87.02 (a)
Adamts3 16
Adamts3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS3 35
  • 99.5 (n)
  • 99.5 (a)
ADAMTS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts3 35
  • 87.96 (n)
  • 92.84 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS3 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS3 35
  • 77.3 (n)
  • 81.56 (a)
ADAMTS3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts3 35
  • 73.57 (n)
  • 76.19 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568788 35
  • 71.97 (n)
  • 77.75 (a)
adamts3 36
  • 77 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C37C3.6a 37
  • 34 (a)
C37C3.6b 37
  • 34 (a)
F08C6.1 37
  • 24 (a)
T19D2.1 37
  • 26 (a)
Species with no ortholog for ADAMTS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS3 Gene

ENSEMBL:
Gene Tree for ADAMTS3 (if available)
TreeFam:
Gene Tree for ADAMTS3 (if available)

Paralogs for ADAMTS3 Gene

(7) SIMAP similar genes for ADAMTS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAMTS3: view

Variants for ADAMTS3 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs788908 - 72,548,569(-) CCGGA(A/G)AACAG reference, missense
rs35864003 - 72,283,534(+) GTTAG(A/C/G)GATGA reference, missense
rs2682 -- 72,281,012(+) TACAA(A/C)AAACA utr-variant-3-prime
rs919981 -- 72,415,085(+) TTTTC(C/T)TTCCA intron-variant
rs922739 -- 72,418,565(+) TGAGG(A/G)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS3 Gene

Variant ID Type Subtype PubMed ID
nsv829968 CNV Gain 17160897
nsv819500 CNV Loss 19587683
nsv879481 CNV Loss 21882294
esv2727811 CNV Deletion 23290073
esv2727812 CNV Deletion 23290073
dgv5633n71 CNV Loss 21882294
nsv879483 CNV Loss 21882294
esv2727813 CNV Deletion 23290073
esv2727814 CNV Deletion 23290073
esv2727815 CNV Deletion 23290073
esv2727816 CNV Deletion 23290073
esv2663516 CNV Deletion 23128226
esv1789836 CNV Insertion 17803354
esv1266268 CNV Insertion 17803354
dgv1643e1 CNV Complex 17122850
dgv1644e1 CNV Complex 17122850
esv1024654 CNV Insertion 17803354
nsv291650 CNV Insertion 16902084
nsv4385 CNV Loss 18451855
esv2727817 CNV Deletion 23290073
esv2079277 CNV Deletion 18987734
esv2727819 CNV Deletion 23290073
esv2727820 CNV Deletion 23290073
esv1992065 CNV Deletion 18987734
esv4638 CNV Deletion 18987735
esv996163 CNV Deletion 20482838
nsv289840 CNV Loss 16902084
esv1255200 CNV Deletion 17803354
esv2727821 CNV Deletion 23290073
esv22832 CNV Gain+Loss 19812545
esv2667909 CNV Deletion 23128226
nsv514226 CNV Loss 21397061
nsv441889 CNV CNV 18776908
dgv1645e1 CNV Complex 17122850
essv9286 CNV CNV 17122850
nsv829969 CNV Gain 17160897
nsv819816 CNV Gain 19587683

Variation tolerance for ADAMTS3 Gene

Residual Variation Intolerance Score: 3.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS3 Gene

HapMap Linkage Disequilibrium report
ADAMTS3
Human Gene Mutation Database (HGMD)
ADAMTS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS3 Gene

Disorders for ADAMTS3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ADAMTS3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone deterioration disease
degenerative disc disease
  • lumbar disc degeneration
bone structure disease
bone inflammation disease
  • bone inflammatory disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAMTS3

Genetic Association Database (GAD)
ADAMTS3
Human Genome Epidemiology (HuGE) Navigator
ADAMTS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS3
genes like me logo Genes that share disorders with ADAMTS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS3 Gene

Publications for ADAMTS3 Gene

  1. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. (PMID: 11408482) Fernandes R.J. … Apte S.S. (J. Biol. Chem. 2001) 3 4 23 67
  2. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. (PMID: 10094461) Tang B.L. … Hong W. (FEBS Lett. 1999) 2 3
  3. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PMID: 10464288) Hurskainen T.L. … Apte S.S. (J. Biol. Chem. 1999) 3 23
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. (PMID: 24552833) Jeltsch M. … Alitalo K. (Circulation 2014) 3

Products for ADAMTS3 Gene

Sources for ADAMTS3 Gene

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