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Aliases for ADAMTS20 Gene

Aliases for ADAMTS20 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 20 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 20 2 3
  • ADAM-TS20 3 4
  • ADAMTS-20 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 20 3
  • EC 63
  • EC 63
  • EC 3.4.24.- 4
  • ADAM-TS 20 4
  • GON-1 3

External Ids for ADAMTS20 Gene

Previous GeneCards Identifiers for ADAMTS20 Gene

  • GC12M043715
  • GC12M043464
  • GC12M042034
  • GC12M040776

Summaries for ADAMTS20 Gene

Entrez Gene Summary for ADAMTS20 Gene

  • The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]

GeneCards Summary for ADAMTS20 Gene

ADAMTS20 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 20) is a Protein Coding gene. Diseases associated with ADAMTS20 include weill-marchesani syndrome. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS20 Gene

  • May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS20 Gene

Genomics for ADAMTS20 Gene

Regulatory Elements for ADAMTS20 Gene

Genomic Location for ADAMTS20 Gene

43,353,866 bp from pter
43,551,921 bp from pter
198,056 bases
Minus strand

Genomic View for ADAMTS20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS20 Gene

Proteins for ADAMTS20 Gene

  • Protein details for ADAMTS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 20
    Protein Accession:
    Secondary Accessions:
    • A6NNC9
    • J3QT00

    Protein attributes for ADAMTS20 Gene

    1910 amino acids
    Molecular mass:
    214721 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS20 Gene


neXtProt entry for ADAMTS20 Gene

Proteomics data for ADAMTS20 Gene at MOPED

Selected DME Specific Peptides for ADAMTS20 Gene

Post-translational modifications for ADAMTS20 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn92, Asn191, Asn445, Asn702, Asn717, Asn728, Asn809, Asn870, Asn1061, Asn1456, Asn1542, Asn1572, Asn1763, Asn1781, and Asn1852
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS20 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADAMTS20 Gene

Gene Families for ADAMTS20 Gene

  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif

Suggested Antigen Peptide Sequences for ADAMTS20 Gene

Graphical View of Domain Structure for InterPro Entry



  • P59510
  • Contains 1 disintegrin domain.
  • Contains 1 GON domain.
  • Contains 1 peptidase M12B domain.
  • Contains 15 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS20: view

Function for ADAMTS20 Gene

Molecular function for ADAMTS20 Gene

UniProtKB/Swiss-Prot Function: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain

Enzyme Numbers (IUBMB) for ADAMTS20 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS20: view
genes like me logo Genes that share phenotypes with ADAMTS20: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS20 Gene

Localization for ADAMTS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS20 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTS20 Gene COMPARTMENTS Subcellular localization image for ADAMTS20 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0031012 colocalizes_with extracellular matrix TAS 22261194
genes like me logo Genes that share ontologies with ADAMTS20: view

Pathways for ADAMTS20 Gene

SuperPathways for ADAMTS20 Gene

No Data Available

Interacting Proteins for ADAMTS20 Gene

Selected Interacting proteins: P59510-ATS20_HUMAN for ADAMTS20 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0030198 extracellular matrix organization IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045636 positive regulation of melanocyte differentiation IEA --
genes like me logo Genes that share ontologies with ADAMTS20: view

No data available for Pathways by source for ADAMTS20 Gene

Transcripts for ADAMTS20 Gene

mRNA/cDNA for ADAMTS20 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS20 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1: -

Relevant External Links for ADAMTS20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS20 Gene

mRNA expression in normal human tissues for ADAMTS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS20 Gene

This gene is overexpressed in Testis (11.3), Brain - Caudate (basal ganglia) (4.9), Brain - Hypothalamus (4.1), and Brain - Substantia nigra (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS20 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS20 Gene Hs.287554

mRNA Expression by UniProt/SwissProt for ADAMTS20 Gene

Tissue specificity: Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas
genes like me logo Genes that share expressions with ADAMTS20: view

Orthologs for ADAMTS20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS20 36
  • 99 (a)
(Bos Taurus)
Mammalia ADAMTS20 35
  • 84.38 (n)
  • 75.26 (a)
(Canis familiaris)
Mammalia ADAMTS20 35
  • 84.63 (n)
  • 75.76 (a)
  • 75 (a)
(Mus musculus)
Mammalia Adamts20 35
  • 77.28 (n)
  • 71 (a)
Adamts20 16
Adamts20 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS20 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Adamts20 35
  • 74.12 (n)
  • 68.15 (a)
(Gallus gallus)
Aves ADAMTS20 35
  • 70.85 (n)
  • 63.97 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia ADAMTS20 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts20 35
  • 64.29 (n)
  • 57.42 (a)
(Danio rerio)
Actinopterygii ADAMTS20 36
  • 59 (a)
Species with no ortholog for ADAMTS20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS20 Gene

Gene Tree for ADAMTS20 (if available)
Gene Tree for ADAMTS20 (if available)

Paralogs for ADAMTS20 Gene

genes like me logo Genes that share paralogs with ADAMTS20: view

Variants for ADAMTS20 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs166700 -- 43,542,992(-) TGGAC(C/T)TCAAT intron-variant
rs169327 -- 43,540,122(-) GAGGC(C/T)GAGGC intron-variant
rs175724 -- 43,545,509(-) AATGA(A/C)ATAAT intron-variant
rs185691 -- 43,542,831(+) TTTGA(C/T)GGAGT intron-variant
rs275370 -- 43,524,249(-) tatga(A/G)ttcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS20 Gene

Variant ID Type Subtype PubMed ID
nsv819620 CNV Loss 19587683
nsv513359 CNV Insertion 21212237
esv2645498 CNV Insertion 19546169
esv1641593 CNV Insertion 17803354

Relevant External Links for ADAMTS20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS20 Gene

Disorders for ADAMTS20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADAMTS20 Gene including...

Search for ADAMTS20 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADAMTS20 Gene

Relevant External Links for ADAMTS20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADAMTS20: view

No data available for UniProtKB/Swiss-Prot for ADAMTS20 Gene

Publications for ADAMTS20 Gene

  1. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 2 3 4 23
  2. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. (PMID: 12562771) Llamazares M. … Lopez-Otin C. (J. Biol. Chem. 2003) 2 3 4
  3. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PMID: 22379998) McCormack M. … Cavalleri G.L. (Pharmacogenomics 2012) 3 48
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert J.C. … Amouyel P. (Nat. Genet. 2013) 3

Products for ADAMTS20 Gene

Sources for ADAMTS20 Gene

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