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Aliases for ADAMTS20 Gene

Aliases for ADAMTS20 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 20 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 20 2 3
  • ADAM-TS20 3 4
  • ADAMTS-20 3 4
  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 20 3
  • EC 3.4.24.14 63
  • EC 3.4.24.82 63
  • EC 3.4.24.- 4
  • ADAM-TS 20 4
  • GON-1 3

External Ids for ADAMTS20 Gene

Previous GeneCards Identifiers for ADAMTS20 Gene

  • GC12M043715
  • GC12M043464
  • GC12M042034
  • GC12M040776

Summaries for ADAMTS20 Gene

Entrez Gene Summary for ADAMTS20 Gene

  • The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]

GeneCards Summary for ADAMTS20 Gene

ADAMTS20 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 20) is a Protein Coding gene. Among its related pathways are Infectious disease and Diseases associated with O-glycosylation of proteins. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot for ADAMTS20 Gene

  • May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS20 Gene

Genomics for ADAMTS20 Gene

Regulatory Elements for ADAMTS20 Gene

Enhancers for ADAMTS20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS20 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS20 Gene

Chromosome:
12
Start:
43,352,843 bp from pter
End:
43,551,940 bp from pter
Size:
199,098 bases
Orientation:
Minus strand

Genomic View for ADAMTS20 Gene

Genes around ADAMTS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS20 Gene

Proteins for ADAMTS20 Gene

  • Protein details for ADAMTS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59510-ATS20_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 20
    Protein Accession:
    P59510
    Secondary Accessions:
    • A6NNC9
    • J3QT00

    Protein attributes for ADAMTS20 Gene

    Size:
    1910 amino acids
    Molecular mass:
    214721 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS20 Gene

Proteomics data for ADAMTS20 Gene at MOPED

Selected DME Specific Peptides for ADAMTS20 Gene

Post-translational modifications for ADAMTS20 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 92, Asn 191, Asn 445, Asn 702, Asn 717, Asn 728, Asn 809, Asn 870, Asn 1061, Asn 1456, Asn 1542, Asn 1572, Asn 1763, Asn 1781, and Asn 1852
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS20 Gene

Domains & Families for ADAMTS20 Gene

Gene Families for ADAMTS20 Gene

Suggested Antigen Peptide Sequences for ADAMTS20 Gene

Graphical View of Domain Structure for InterPro Entry

P59510

UniProtKB/Swiss-Prot:

ATS20_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 GON domain.
  • Contains 1 peptidase M12B domain.
  • Contains 15 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS20: view

Function for ADAMTS20 Gene

Molecular function for ADAMTS20 Gene

UniProtKB/Swiss-Prot Function:
May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Enzyme Numbers (IUBMB) for ADAMTS20 Gene

genes like me logo Genes that share phenotypes with ADAMTS20: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS20 Gene

Localization for ADAMTS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS20 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS20 Gene COMPARTMENTS Subcellular localization image for ADAMTS20 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 2
golgi apparatus 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031012 colocalizes_with extracellular matrix IEA,TAS 22261194
genes like me logo Genes that share ontologies with ADAMTS20: view

Pathways & Interactions for ADAMTS20 Gene

genes like me logo Genes that share pathways with ADAMTS20: view

Interacting Proteins for ADAMTS20 Gene

Selected Interacting proteins: P59510-ATS20_HUMAN for ADAMTS20 Gene via I2D

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0048070 regulation of developmental pigmentation IEA --
genes like me logo Genes that share ontologies with ADAMTS20: view

No data available for SIGNOR curated interactions for ADAMTS20 Gene

Drugs & Compounds for ADAMTS20 Gene

No Compound Related Data Available

Transcripts for ADAMTS20 Gene

mRNA/cDNA for ADAMTS20 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS20 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1: -
SP2:

Relevant External Links for ADAMTS20 Gene

GeneLoc Exon Structure for
ADAMTS20
ECgene alternative splicing isoforms for
ADAMTS20

Expression for ADAMTS20 Gene

mRNA expression in normal human tissues for ADAMTS20 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS20 Gene

This gene is overexpressed in Testis (x11.3), Brain - Caudate (basal ganglia) (x4.9), Brain - Hypothalamus (x4.1), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for ADAMTS20 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS20 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS20 Gene Hs.287554

mRNA Expression by UniProt/SwissProt for ADAMTS20 Gene

P59510-ATS20_HUMAN
Tissue specificity: Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.
genes like me logo Genes that share expression patterns with ADAMTS20: view

Protein tissue co-expression partners for ADAMTS20 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAMTS20 Gene

Orthologs for ADAMTS20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS20 35
  • 84.38 (n)
  • 75.26 (a)
dog
(Canis familiaris)
Mammalia ADAMTS20 35
  • 84.63 (n)
  • 75.76 (a)
ADAMTS20 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts20 35
  • 77.28 (n)
  • 71 (a)
Adamts20 16
Adamts20 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts20 35
  • 74.12 (n)
  • 68.15 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS20 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS20 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS20 35
  • 70.85 (n)
  • 63.97 (a)
ADAMTS20 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS20 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts20 35
  • 64.29 (n)
  • 57.42 (a)
zebrafish
(Danio rerio)
Actinopterygii ADAMTS20 36
  • 59 (a)
OneToOne
Species with no ortholog for ADAMTS20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS20 Gene

ENSEMBL:
Gene Tree for ADAMTS20 (if available)
TreeFam:
Gene Tree for ADAMTS20 (if available)

Paralogs for ADAMTS20 Gene

genes like me logo Genes that share paralogs with ADAMTS20: view

Variants for ADAMTS20 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7302446 - 43,434,338(+) CACTC(A/T)TATGT reference, missense
rs7297737 - 43,432,401(+) CAAGA(C/T)GATGG reference, missense
rs7310011 - 43,428,368(+) CAGGG(A/G)AACTA reference, missense
rs1949083 -- 43,477,426(+) TTGTA(A/G/T)GGAGG intron-variant
rs1949084 -- 43,411,361(+) TTGTT(C/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS20 Gene

Variant ID Type Subtype PubMed ID
nsv819620 CNV Loss 19587683
nsv513359 CNV Insertion 21212237
esv2645498 CNV Insertion 19546169
esv1641593 CNV Insertion 17803354

Variation tolerance for ADAMTS20 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADAMTS20 Gene

Disorders for ADAMTS20 Gene

Relevant External Links for ADAMTS20

Genetic Association Database (GAD)
ADAMTS20
Human Genome Epidemiology (HuGE) Navigator
ADAMTS20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS20

No disorders were found for ADAMTS20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS20 Gene

Publications for ADAMTS20 Gene

  1. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. (PMID: 12562771) Llamazares M. … Lopez-Otin C. (J. Biol. Chem. 2003) 2 3
  3. Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. (PMID: 25798845) Wolf Z.T. … Bannasch D.L. (PLoS Genet. 2015) 3
  4. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert J.C. … Amouyel P. (Nat. Genet. 2013) 3
  5. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3

Products for ADAMTS20 Gene

Sources for ADAMTS20 Gene

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