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ADAMTS20 Gene

protein-coding   GIFtS: 53
GCID: GC12M043715

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See ADAMTS20-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 201 2     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 202
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 201 2
     EC 3.4.24.-3
ADAM-TS202 3     ADAM-TS 203
ADAMTS-202 3     EC 3.4.24.148
GON-12     EC 3.4.24.828

External Ids:    HGNC: 171781   Entrez Gene: 800702   Ensembl: ENSG000001731577   OMIM: 6116815   UniProtKB: P595103   

Export aliases for ADAMTS20 gene to outside databases

Previous GC identifers: GC12M043464 GC12M042034 GC12M040776


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS20 Gene:
The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein
has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the
extracellular matrix. This protein may be involved in tissue remodeling. (provided by RefSeq, Sep 2011)

GeneCards Summary for ADAMTS20 Gene:
ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif, 20) is a protein-coding gene. Diseases associated with ADAMTS20 include weill-marchesani syndrome. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS20_HUMAN, P59510
Function: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May
have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of
secretory cargos, mediated by the GON domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS20 gene promoter:
         Nkx3-1   GR   SREBP-1c   FOXD3   SREBP-1b   FOXL1   Evi-1   SREBP-1a   FOXJ2 (long isoform)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS20 promoter sequence
   Search Chromatin IP Primers for ADAMTS20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

ADAMTS20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS20 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M043715:  view genomic region     (about GC identifiers)

Start:
43,747,669 bp from pter      End:
43,945,724 bp from pter
Size:
198,056 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATS20_HUMAN, P59510 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 20 precursor  
Size: 1910 amino acids; 214721 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: A6NNC9 J3QT00
Alternative splicing: 3 isoforms:  P59510-1   P59510-2   P59510-3   

Explore the universe of human proteins at neXtProt for ADAMTS20: NX_P59510

Explore proteomics data for ADAMTS20 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn92, Asn191, Asn445, Asn702, Asn717, Asn728, Asn809, Asn870, Asn1061, Asn1456,
                                 Asn1542, Asn1572, Asn1763, Asn1781, Asn1852
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ADAMTS20 (P59510)
     VCGGDNS  CSRSCGGG  DKCGVCGG 


    See ADAMTS20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079279.3  
    ENSEMBL proteins: 
     ENSP00000374071   ENSP00000447427   ENSP00000448341   ENSP00000378911  
    Reactome Protein details: P59510

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS20
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR012314 Pept_M12B_GON-ADAMTSs
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry P59510

    ProtoNet protein and cluster: P59510

    4 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS20_HUMAN, P59510
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 GON domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 15 TSP type-1 domains


    Find genes that share domains with ADAMTS20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS20_HUMAN, P59510
    Function: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May
    have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of
    secretory cargos, mediated by the GON domain

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS20           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTS20:
     Decreased viability of wild-ty 

         7 MGI mutant phenotypes (inferred from 14 alleles(MGI details for Adamts20):
     cellular  embryogenesis  integument  limbs/digits/tail  mortality/aging 
     nervous system  pigmentation 

    Find genes that share phenotypes with ADAMTS20           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS20
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS20_HUMAN, P59510: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytoskeleton1
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0031012colocalizes with extracellular matrix TAS--

    Find genes that share ontologies with ADAMTS20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with ADAMTS20           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAMTS20
        O-glycosylation of TSR domain-containing proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS20
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS20

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ADAMTS20 (P595103 ENSP000003740714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    UNC119ENSP000003370404STRING: ENSP00000337040
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0009967positive regulation of signal transduction IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0045636positive regulation of melanocyte differentiation IEA--

    Find genes that share ontologies with ADAMTS20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS20 (ATS20)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMTS20 gene (2 alternative transcripts): 
    NM_025003.3  NM_175851.1  

    Unigene Cluster for ADAMTS20:

    ADAM metallopeptidase with thrombospondin type 1 motif, 20
    Hs.287554  [show with all ESTs]
    Unigene Representative Sequence: AF488804
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389420(uc010skx.2) ENST00000549670 ENST00000553158(uc001rnp.1)
    ENST00000395541(uc001rno.1)
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    Additional mRNA sequence: 

    AF488804.1 AJ515153.3 AJ515154.2 AK023228.1 

    4 DOTS entries:

    DT.100740815  DT.92066875  DT.91742187  DT.97773791 

    8 AceView cDNA sequences:

    AJ515153 NM_025003 AK023228 NM_175851 AU132053 AF488804 AJ515154 AU153670 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS20    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                  -         

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
    SP1:                    -                                                                     
    SP2:                                                                                          


    ECgene alternative splicing isoforms for ADAMTS20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGTTTAT
    ADAMTS20 Expression
    About this image


    ADAMTS20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ADAMTS20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287554

    UniProtKB/Swiss-Prot: ATS20_HUMAN, P59510
    Tissue specificity: Very sparingly expressed, although is detected at low levels in testis, prostate, ovary,
    heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS20 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts201 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 77.28(n)1
    71(a)1
      15 (48.20 cM)5
    2238381  NM_177431.41  NP_803180.31 
     942701635 
    chicken
    (Gallus gallus)
    Aves ADAMTS201 ADAM metallopeptidase with thrombospondin type 1 motif, more 70.85(n)
    63.97(a)
      417794  XM_416037.4  XP_416037.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS206
    ADAM metallopeptidase with thrombospondin type 1 m...
    61(a)
    1 ↔ 1
    5(54682436-54798574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts201 ADAM metallopeptidase with thrombospondin type 1 motif, more 64.29(n)
    57.42(a)
      100489781  XM_002932822.2  XP_002932868.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ADAMTS206
    ADAM metallopeptidase with thrombospondin type 1 m...
    59(a)
    1 ↔ 1
    Zv9_NA761(266-42075) ENSDARG00000074281


    ENSEMBL Gene Tree for ADAMTS20 (if available)
    TreeFam Gene Tree for ADAMTS20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS20 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    13 SIMAP similar genes for ADAMTS20 using alignment to 5 protein entries:     ATS20_HUMAN (see all proteins):
    ADAMTS4    ADAMTS9    ADAMTS8    ADAMTS1    ADAMTS15    DKFZp686E01144
    ADAMTS13    ADAMTSL1    ADAMTS6    ADAMTS18    ADAMTS2    ADAMTS10
    ADAMTS16

    Find genes that share paralogs with ADAMTS20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS20 (see all 3874)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790651131,2
    C,Funtested143688398(+) ACAACA/G/TATCCT 2 R C mis11EA 120
    rs1442499631,2
    C--40776731(+) AATGA-/TTTTTA 1 -- int10--------
    rs1445382551,2
    C--40780961(+) GTGTG-/TTAA  
            
    TTAAT
    1 -- int10--------
    rs352482811,2
    C--40782095(+) CATAT-/AAAAAA 1 -- int10--------
    rs1122714051,2
    C--40801991(+) ATCACA/-AAAAA 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs1500983951,2
    C--40804834(+) TAGAT-/AAAAAA 1 -- int10--------
    rs2000188391,2
    --40823756(+) TTTTT-/TGTGCTC 1 -- int10--------
    rs740809071,2
    C,F--40843714(+) TTACAC/AAAAAA 1 -- int12Minor allele frequency- A:0.50WA NA 4
    rs348531421,2
    C--40857476(+) AGCAA-/CAGAGA 1 -- int10--------
    rs351128451,2
    C--40858069(+) TTTCT-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ADAMTS20 (43747669 - 43945724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAMTS20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2645498CNV Insertion19546169
    esv1641593CNV Insertion17803354
    nsv513359CNV Insertion21212237
    nsv819620CNV Loss19587683

    2 Site Specific Mutation Identification with PCR Assays for ADAMTS20:
    Cosmic IdAA Change
    142269p.G1870E
    142268p.G1870R
    SeqTarget long-range PCR primers for resequencing ADAMTS20
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611681    OMIM disorders: --

    1 disease for ADAMTS20:    
    About MalaCards
    weill-marchesani syndrome

    1 disease from the University of Copenhagen DISEASES database for ADAMTS20:
    Weill-Marchesani syndrome

    Find genes that share disorders with ADAMTS20           About GenesLikeMe

    Genetic Association Database (GAD): ADAMTS20
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS20 (1 document)

    Export disorders for ADAMTS20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS20 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ADAMTS20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PubMed id 12514189)1, 2, 3, 9 Somerville R.P.... Apte S.S. (J. Biol. Chem. 2003)
    2. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. (PubMed id 12562771)1, 2, 3 Llamazares M.... Lopez-Otin C. (J. Biol. Chem. 2003)
    3. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1, 4 McCormack M....Cavalleri G.L. (Pharmacogenomics 2012)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    5. Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation. (PubMed id 20221248)1 Edwards M....Parra E.J. (PLoS Genet. 2010)
    6. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    7. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80070 HGNC: 17178 AceView: ADAMTS20 Ensembl:ENSG00000173157 euGenes: HUgn80070
    ECgene: ADAMTS20 H-InvDB: ADAMTS20

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADAMTS20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS20 gene:
    Search GeneIP for patents involving ADAMTS20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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