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Aliases for ADAMTS20 Gene

Aliases for ADAMTS20 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 20 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 20 2 3
  • ADAM-TS20 3 4
  • ADAMTS-20 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 20 3
  • EC 3.4.24.14 61
  • EC 3.4.24.82 61
  • EC 3.4.24.- 4
  • ADAM-TS 20 4
  • GON-1 3

External Ids for ADAMTS20 Gene

Previous GeneCards Identifiers for ADAMTS20 Gene

  • GC12M043715
  • GC12M043464
  • GC12M042034
  • GC12M040776

Summaries for ADAMTS20 Gene

Entrez Gene Summary for ADAMTS20 Gene

  • The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]

GeneCards Summary for ADAMTS20 Gene

ADAMTS20 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 20) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Diseases of glycosylation. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS9.

UniProtKB/Swiss-Prot for ADAMTS20 Gene

  • May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS20 Gene

Genomics for ADAMTS20 Gene

Regulatory Elements for ADAMTS20 Gene

Enhancers for ADAMTS20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G043111 0.8 FANTOM5 ENCODE 1.4 +439.2 439221 2.4 CTCF HLF RAD21 ADAMTS20 LINC02461 MRPS36P5
GH12G043551 1.1 Ensembl ENCODE 0.7 -0.1 -84 1.2 ZSCAN4 ZNF76 GLI4 ZNF2 GLIS2 ZNF366 ZNF263 SP3 ZNF426 REST PRICKLE1 ADAMTS20 RPL21P101
GH12G043552 0.5 ENCODE 0.7 +0.8 788 0.1 ZNF34 ZBTB48 SUZ12 ZNF426 EZH2 ADAMTS20 GC12M043220
GH12G043338 1.1 Ensembl ENCODE 0.1 +212.9 212919 1.2 PKNOX1 THRB RAD21 GATA2 FOS IKZF2 ZNF654 JUNB TBX21 NR2F2 PRICKLE1 GC12M043220 ADAMTS20
GH12G043370 0.7 ENCODE 0.1 +181.3 181348 0.2 PKNOX1 JUN ZNF366 ZNF169 ZNF350 RCOR1 FOS KLF8 SP3 HLF GC12M043220 ADAMTS20
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAMTS20 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS20 Gene

Chromosome:
12
Start:
43,352,843 bp from pter
End:
43,551,940 bp from pter
Size:
199,098 bases
Orientation:
Minus strand

Genomic View for ADAMTS20 Gene

Genes around ADAMTS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS20 Gene

Proteins for ADAMTS20 Gene

  • Protein details for ADAMTS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59510-ATS20_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 20
    Protein Accession:
    P59510
    Secondary Accessions:
    • A6NNC9
    • J3QT00

    Protein attributes for ADAMTS20 Gene

    Size:
    1910 amino acids
    Molecular mass:
    214721 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS20 Gene

Selected DME Specific Peptides for ADAMTS20 Gene

P59510:
  • VCGGDNS
  • CSRSCGGG
  • DKCGVCGG

Post-translational modifications for ADAMTS20 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=9292, posLast=191191, Asn445, posLast=702702, posLast=717717, Asn728, Asn809, Asn870, posLast=10611061, posLast=14561456, Asn1542, Asn1572, posLast=17631763, posLast=17811781, and Asn1852
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS20 Gene

Domains & Families for ADAMTS20 Gene

Gene Families for ADAMTS20 Gene

Suggested Antigen Peptide Sequences for ADAMTS20 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAMTS20: view

No data available for UniProtKB/Swiss-Prot for ADAMTS20 Gene

Function for ADAMTS20 Gene

Molecular function for ADAMTS20 Gene

UniProtKB/Swiss-Prot Function:
May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Enzyme Numbers (IUBMB) for ADAMTS20 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS20: view
genes like me logo Genes that share phenotypes with ADAMTS20: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS20 Gene

Localization for ADAMTS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS20 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS20 gene
Compartment Confidence
extracellular 4
cytoskeleton 3
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0031012 colocalizes_with extracellular matrix IEA,TAS 22261194
genes like me logo Genes that share ontologies with ADAMTS20: view

Pathways & Interactions for ADAMTS20 Gene

genes like me logo Genes that share pathways with ADAMTS20: view

Gene Ontology (GO) - Biological Process for ADAMTS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0030198 extracellular matrix organization IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045636 positive regulation of melanocyte differentiation IEA --
genes like me logo Genes that share ontologies with ADAMTS20: view

No data available for SIGNOR curated interactions for ADAMTS20 Gene

Drugs & Compounds for ADAMTS20 Gene

No Compound Related Data Available

Transcripts for ADAMTS20 Gene

mRNA/cDNA for ADAMTS20 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS20 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1: -
SP2:

Relevant External Links for ADAMTS20 Gene

GeneLoc Exon Structure for
ADAMTS20
ECgene alternative splicing isoforms for
ADAMTS20

Expression for ADAMTS20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS20 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS20 Gene

This gene is overexpressed in Testis (x11.3), Brain - Caudate (basal ganglia) (x4.9), Brain - Hypothalamus (x4.1), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for ADAMTS20 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS20 Gene



Protein tissue co-expression partners for ADAMTS20 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS20 Gene:

ADAMTS20

SOURCE GeneReport for Unigene cluster for ADAMTS20 Gene:

Hs.287554

mRNA Expression by UniProt/SwissProt for ADAMTS20 Gene:

P59510-ATS20_HUMAN
Tissue specificity: Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.

Evidence on tissue expression from TISSUES for ADAMTS20 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ADAMTS20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS20 Gene

Orthologs for ADAMTS20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS20 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS20 34 35
  • 84.63 (n)
cow
(Bos Taurus)
Mammalia ADAMTS20 34
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Adamts20 34 16 35
  • 77.28 (n)
rat
(Rattus norvegicus)
Mammalia Adamts20 34
  • 74.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS20 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS20 34 35
  • 70.85 (n)
lizard
(Anolis carolinensis)
Reptilia ADAMTS20 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts20 34
  • 64.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ADAMTS20 35
  • 59 (a)
OneToOne
Species where no ortholog for ADAMTS20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS20 Gene

ENSEMBL:
Gene Tree for ADAMTS20 (if available)
TreeFam:
Gene Tree for ADAMTS20 (if available)

Paralogs for ADAMTS20 Gene

Variants for ADAMTS20 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000006846 -- 43,394,515(+) TTAAC(A/C)TGTAA intron-variant
rs1000016945 -- 43,358,655(+) AACAC(A/G)GTGAA intron-variant
rs1000034026 -- 43,477,837(+) TCAAG(A/G)TGCAT intron-variant
rs1000034831 -- 43,537,247(+) ATGGG(C/G/T)TTTCA intron-variant
rs1000041689 -- 43,446,544(+) AGACT(C/G)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS20 Gene

Variant ID Type Subtype PubMed ID
esv1641593 CNV insertion 17803354
esv2645498 CNV insertion 19546169
nsv1035821 CNV loss 25217958
nsv513359 CNV insertion 21212237
nsv819620 CNV loss 19587683

Variation tolerance for ADAMTS20 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAMTS20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS20 Gene

Disorders for ADAMTS20 Gene

Relevant External Links for ADAMTS20

Genetic Association Database (GAD)
ADAMTS20
Human Genome Epidemiology (HuGE) Navigator
ADAMTS20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS20

No disorders were found for ADAMTS20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS20 Gene

Publications for ADAMTS20 Gene

  1. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. (PMID: 12562771) Llamazares M. … Lopez-Otin C. (J. Biol. Chem. 2003) 2 3 4 64
  3. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PMID: 22379998) McCormack M. … Cavalleri G.L. (Pharmacogenomics 2012) 3 46 64
  4. Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. (PMID: 25798845) Wolf Z.T. … Bannasch D.L. (PLoS Genet. 2015) 3 64
  5. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert J.C. … Amouyel P. (Nat. Genet. 2013) 3 64

Products for ADAMTS20 Gene

Sources for ADAMTS20 Gene

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