Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS2 Gene

protein-coding   GIFtS: 59
GCID: GC05M178537

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 21 2     EC 3.4.24.143 8
Procollagen I N-Proteinase1 2 3     NPI2 5
Procollagen N-Endopeptidase1 2 3     ADAMTS-32
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 21 2
     PCI-NP2
Procollagen I/II Amino Propeptide-Processing Enzyme2 3     PNPI2
ADAM-TS22 3     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 22
ADAMTS-22 3     ADAM-TS 23
PCINP2 3     pNPI3
PCPNI2 3     EC 3.4.248
PC I-NP2 3     

External Ids:    HGNC: 2181   Entrez Gene: 95092   Ensembl: ENSG000000871167   OMIM: 6045395   UniProtKB: O954503   

Export aliases for ADAMTS2 gene to outside databases

Previous GC identifers: GC05M178625 GC05M179449 GC05M178654 GC05M178473 GC05M173265


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS2 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme
encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene
cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2010)

GeneCards Summary for ADAMTS2 Gene: 
ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif, 2) is a protein-coding gene. Diseases associated with ADAMTS2 include ehlers-danlos syndrome dermatosparaxis type, and anosognosia, and among its related super-pathways are Collagen formation. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS2_HUMAN, O95450
Function: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III
collagen. May also play a role in development that is independent of its role in collagen biosynthesis

Gene Wiki entry for ADAMTS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS2 gene promoter:
         USF1   USF2   USF-1:USF-2   E47   S8   E2F   E2F-1   USF-1   SEF-1 (1)   Hand1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADAMTS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5qter   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q23-q24

ADAMTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M178537:  view genomic region     (about GC identifiers)

Start:
178,537,852 bp from pter      End:
178,772,431 bp from pter
Size:
234,580 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS2_HUMAN, O95450 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor  
Size: 1211 amino acids; 134755 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: May belong to a multimeric complex. Binds specifically to collagen type XIV (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Caution: Has sometimes been referred to as ADAMTS3
Alternative splicing: 2 isoforms:  O95450-1   O95450-2   (Has no significant N-procollagen peptidase activity)

Explore the universe of human proteins at neXtProt for ADAMTS2: NX_O95450

Explore proteomics data for ADAMTS2 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95450

  • 4/20 DME Specific Peptides for ADAMTS2 (O95450) (see all 20)
     VCGGDNS  TKYGCRR  SNCDGLAG  EQCRFDFG 

    ADAMTS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055059.2  NP_067610.1  

    ENSEMBL proteins: 
     ENSP00000251582   ENSP00000274609  
    Reactome Protein details: O95450
    Human Recombinant Protein Products for ADAMTS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADAMTS2
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS2
    Novus Biologicals ADAMTS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMTS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTS2 for ontologies           About GeneDecksing



    ADAMTS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADAMTS2
    OriGene Custom Antibody Services for ADAMTS2
    GenScript Custom Superior Antibodies Services for ADAMTS2
    Novus Biologicals ADAMTS2 Antibodies
    Abcam antibodies for ADAMTS2
    Cloud-Clone Corp. Antibodies for ADAMTS2 
    ThermoFisher Antibodies for ADAMTS2
    LSBio Antibodies in human, mouse, rat for ADAMTS2 

    Assay Products for ADAMTS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAMTS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAMTS2 
    Cloud-Clone Corp. CLIAs for ADAMTS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS2 
    ADAMTS family

    5/8 InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry O95450

    ProtoNet protein and cluster: O95450

    5/6 Blocks protein domains (see all 6):
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS2_HUMAN, O95450
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 4 TSP type-1 domains


    ADAMTS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS2_HUMAN, O95450
    Function: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III
    collagen. May also play a role in development that is independent of its role in collagen biosynthesis
    Catalytic activity: Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro- -Gln and of alpha-1(II) and
    alpha-2(I) at Ala- -Gln

         Genatlas biochemistry entry for ADAMTS2:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 2,extracellular
    matrix protein

         Enzyme Numbers (IUBMB): EC 3.4.24.141 2 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity TAS10417273
    GO:0008270zinc ion binding IEA--
         
    ADAMTS2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adamts2):
     craniofacial  integument  normal  reproductive system  respiratory system 
     skeleton 

    ADAMTS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adamts2tm1Prc for ADAMTS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAMTS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS2 (see all 26):
    hsa-miR-4291 hsa-miR-1178 hsa-miR-330-5p hsa-miR-2110 hsa-miR-767-5p hsa-miR-29a hsa-miR-29c hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAMTS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAMTS2
    Sirion Biotech Customized adenovirus for overexpression of ADAMTS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADAMTS2 (see all 7)
    OriGene ORF clones in mouse, rat for ADAMTS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAMTS2 (NM_014244)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS2
    Sirion Biotech Customized lentivirus for stable overexpression of ADAMTS2 
                         Customized lentivirus expression plasmids for stable overexpression of ADAMTS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAMTS2
    Search LifeMap BioReagents cell lines for ADAMTS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAMTS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Extracellular matrix organization0.39
    Collagen formation0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ADAMTS2
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    ADAMTS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ADAMTS2 (O954503 ENSP000002515824) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    PIK3R5Q8WYR13, ENSP000002693004I2D: score=1 STRING: ENSP00000269300
    BMP1ENSP000003057144STRING: ENSP00000305714
    PCOLCEENSP000002230614STRING: ENSP00000223061
    TLL1ENSP000000612404STRING: ENSP00000061240
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007283spermatogenesis IEA--
    GO:0016485protein processing IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--

    ADAMTS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAMTS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS2 (ATS2)

    1 HMDB Compound for ADAMTS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for ADAMTS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    procollagen 74.7 6 18542833 (2), 18084737 (1), 15389701 (1), 12646579 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS2 / ATS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS2 gene (2 alternative transcripts): 
    NM_014244.4  NM_021599.2  

    Unigene Cluster for ADAMTS2:

    ADAM metallopeptidase with thrombospondin type 1 motif, 2
    Hs.23871  [show with all ESTs]
    Unigene Representative Sequence: NM_014244
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251582(uc003mjw.3) ENST00000522937 ENST00000523450 ENST00000518335
    ENST00000274609(uc011dgm.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS2 (see all 26):
    hsa-miR-4291 hsa-miR-1178 hsa-miR-330-5p hsa-miR-2110 hsa-miR-767-5p hsa-miR-29a hsa-miR-29c hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAMTS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS2
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS2 (see all 7)
    OriGene ORF clones in mouse, rat for ADAMTS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAMTS2 (NM_014244)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS2
    Sirion Biotech Customized lentivirus for stable overexpression of ADAMTS2 
                         Customized lentivirus expression plasmids for stable overexpression of ADAMTS2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS2
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS2

    Additional mRNA sequence: 

    AJ003125.1 AK308213.1 BC098581.1 BX537606.1 

    4 DOTS entries:

    DT.202953  DT.97825427  DT.91828867  DT.95150484 

    24/175 AceView cDNA sequences (see all 175):

    CB216501 AA994052 CK902585 CA411745 BQ017847 AI128928 BX479109 T47635 
    BQ019905 AI240132 AA664436 AI097350 BQ574410 AI147135 AI753961 AW583281 
    CA441693 NM_021599 AI393865 BF058422 CK725208 AA150145 AA732806 AL046910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS2 expression in normal human tissues (normalized intensities)      ADAMTS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAMTS2 Expression
    About this image


    ADAMTS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Wharton's jelly-derived stem cells
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Fibroblast
             Detroit 551
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Breast (Uncategorized)
             breast stroma   

    See ADAMTS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS2

    SOURCE GeneReport for Unigene cluster: Hs.23871

    UniProtKB/Swiss-Prot: ATS2_HUMAN, O95450
    Tissue specificity: Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain

        SABiosciences Custom PCR Arrays for ADAMTS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS2
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts21 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 86.83(n)1
    88.84(a)1
      11 (30.78 cM)5
    2167251  NM_175643.21  NP_783574.11 
     506020845 
    chicken
    (Gallus gallus)
    Aves ADAMTS21 ADAM metallopeptidase with thrombospondin type 1 motif, more 71.82(n)
    76.32(a)
      416291  XM_414611.3  XP_414611.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS26
    Uncharacterized protein
    73(a)
    1 ↔ 1
    2(140656003-140956700)
    zebrafish
    (Danio rerio)
    Actinopterygii adamts31 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.07(n)
    64.17(a)
      571682  XM_695292.2  XP_700384.2 


    ENSEMBL Gene Tree for ADAMTS2 (if available)
    TreeFam Gene Tree for ADAMTS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS2 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    7 SIMAP similar genes for ADAMTS2 using alignment to 1 protein entry:     ATS2_HUMAN:
    ADAMTS14    ADAMTS3    ADAMTS13    ADAMTS20    ADAMTS1    ADAMTS4
    DKFZp686E01144

    ADAMTS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6256 SNPs in ADAMTS2 are shown (see all 6256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011967111,2
    --173270234(+) AGGGA-/GGGAGA 1 -- int10--------
    rs37768081,2
    C--173270236(+) GGAGGA/GAGAAA 1 -- int10--------
    rs37768091,2
    C--173270237(+) GAGGGA/GGAAAG 1 -- int10--------
    rs557351291,2
    C--173276863(+) CAGGC-/ACCCCCCA
    CTCACACAGGC
    GTCCC
    1 -- int10--------
    rs77021351,2
    C,A,H--173276864(+) CAGGCG/ATCCCC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs77267351,2
    C,A,H--173276865(+) AGGCGC/TCCCCC 1 -- int10--------
    rs2022019551,2
    --173289284(+) CTCCA-/TGCTCC 1 -- int10--------
    rs12986511,2
    C--173289304(-) gggggA/Ctggag 1 -- int10--------
    rs1893163311,2
    --173289305(+) TCCATA/CCCCCA 1 -- int10--------
    rs1808106151,2
    --173289326(+) CCAGCC/TCCCAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ADAMTS2 (178537852 - 178772431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/57 variations for ADAMTS2 (see all 57):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1695463CNV Deletion17803354
    esv2731286CNV Deletion23290073
    esv2659777CNV Deletion23128226
    esv991289CNV Deletion20482838
    esv2731289CNV Deletion23290073
    esv2731275CNV Deletion23290073
    esv2664480CNV Deletion23128226
    esv988467CNV Deletion20482838
    esv1300070CNV Deletion17803354
    esv2731278CNV Deletion23290073


    Human Gene Mutation Database (HGMD): ADAMTS2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS2
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604539   
    OMIM disorders: 225410  
    UniProtKB/Swiss-Prot: ATS2_HUMAN, O95450
  • Ehlers-Danlos syndrome 7C (EDS7C) [MIM:225410]: A connective tissue disorder characterized by
    hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Marked by extremely
    fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis
    laxa syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 19 diseases for ADAMTS2:    About MalaCards
    ehlers-danlos syndrome dermatosparaxis type    anosognosia    exhibitionism    ehlers-danlos syndrome
    lewy body dementia    cutis laxa    osteogenesis imperfecta    dementia
    connective tissue disease    vascular dementia    frontotemporal dementia    attention deficit hyperactivity disorder
    brain disease    acute myocardial infarction    myocardial infarction    renal cell carcinoma
    parkinson's disease    retinitis    endotheliitis

    4 diseases from the University of Copenhagen DISEASES database for ADAMTS2:
    Alzheimer's disease     Brain disease     Ehlers-Danlos syndrome     Anosognosia

    ADAMTS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for ADAMTS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatosparaxis 97.8 12 10417273 (3), 1642226 (1), 11408482 (1), 15389701 (1) (see all 7)
    ehlers-danlos syndrome 88.9 7 10417273 (1), 15373769 (1), 11408482 (1), 15389701 (1) (see all 6)
    connective tissue diseases 45.5 1 15389701 (1)
    cancer 0 1 15538223 (1)

    Genetic Association Database (GAD): ADAMTS2

    Export disorders for ADAMTS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with ADAMTS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. (PubMed id 10417273)1, 2, 9 Colige A.... Nusgens B.V. (1999)
    2. Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene. (PubMed id 15373769)1, 3, 9 Colige A....Nusgens B.V. (2004)
    3. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (2008)
    4. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. (PubMed id 10094461)1, 3 Tang B.L. and Hong W. (1999)
    5. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. (PubMed id 10464288)1, 9 Hurskainen T.L.... Apte S.S. (1999)
    6. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. (PubMed id 11741898)1, 9 Colige A.... Nusgens B.V. (2002)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. A genome-wide association study identifies a gene netw ork of ADAMTS genes in the predisposition to pediatric stroke. (PubMed id 22990015)1 Arning A....Nowak-Gottl U. (2012)
    9. Expression of ADAMTS-2, -3, -13, and -14 in culprit co ronary lesions in patients with acute myocardial infarction or stable angina. (PubMed id 22205175)1 Lee C.W....Park S.J. (2012)
    10. ADAMTS-2 functions as anti-angiogenic and anti-tumora l molecule independently of its catalytic activity. (PubMed id 20574651)1 Dubail J....Colige A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9509 HGNC: 218 AceView: ADAMTS2 Ensembl:ENSG00000087116 euGenes: HUgn9509
    ECgene: ADAMTS2 H-InvDB: ADAMTS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS2 gene:
    Search GeneIP for patents involving ADAMTS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADAMTS2   OriGene RNAi products in human, mouse, rat for ADAMTS2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAMTS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAMTS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS2   OriGene Custom Protein Services for ADAMTS2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS2
     QIAGEN SeqTarget long-range PCR primers for resequencing ADAMTS2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS2
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS2
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS2 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS2
     GenScript Custom Assay Services for ADAMTS2 GenScript Custom Superior Antibodies Services for ADAMTS2
     GenScript Custom overexpressing Cell Line Services for ADAMTS2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAMTS2 promoter
     Search Chromatin IP Primers for ADAMTS2
     RT2 qPCR Primer Assay in human, mouse, rat ADAMTS2
     Search GNC Networks for ADAMTS2
     SABiosciences Custom PCR Arrays for ADAMTS2
     Search Tocris compounds for ADAMTS2 (ATS2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAMTS2 antibodies
     ADAMTS2 proteins
     Antibodies for ADAMTS2
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADAMTS2
     Antibodies for ADAMTS2
     ELISAs for ADAMTS2
     CLIAs for ADAMTS2
     Search LifeMap BioReagents cell lines for ADAMTS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS2
     Browse SwitchGear Promoter luciferase reporter plasmids for ADAMTS2
     ThermoFisher Antibodies for ADAMTS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAMTS2
    Customized:
     lentivirus for stable overexpression of ADAMTS2
     lentivirus expression plasmids for stable overexpression of ADAMTS2
     adenovirus for overexpression of ADAMTS2
     LSBio Antibodies in human, mouse, rat for ADAMTS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAMTS2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4