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Aliases for ADAMTS19 Gene

Aliases for ADAMTS19 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 19 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 19 2 3
  • ADAM-TS 19 3 4
  • ADAM-TS19 3 4
  • ADAMTS-19 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 19 3
  • EC 3.4.24.- 4

External Ids for ADAMTS19 Gene

Previous GeneCards Identifiers for ADAMTS19 Gene

  • GC05P128337
  • GC05P129231
  • GC05P128826
  • GC05P128872
  • GC05P128824
  • GC05P123989

Summaries for ADAMTS19 Gene

Entrez Gene Summary for ADAMTS19 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS19 Gene

ADAMTS19 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 19) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS16.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS19 Gene

Genomics for ADAMTS19 Gene

Regulatory Elements for ADAMTS19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS19 Gene

Start:
129,460,265 bp from pter
End:
129,738,683 bp from pter
Size:
278,419 bases
Orientation:
Plus strand

Genomic View for ADAMTS19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS19 Gene

Proteins for ADAMTS19 Gene

  • Protein details for ADAMTS19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE59-ATS19_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 19
    Protein Accession:
    Q8TE59
    Secondary Accessions:

    Protein attributes for ADAMTS19 Gene

    Size:
    1207 amino acids
    Molecular mass:
    134048 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS19 Gene

Proteomics data for ADAMTS19 Gene at MOPED

Post-translational modifications for ADAMTS19 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn260, Asn797, Asn907, Asn949, and Asn1009
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTS19 Gene

Domains for ADAMTS19 Gene

Gene Families for ADAMTS19 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

Suggested Antigen Peptide Sequences for ADAMTS19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE59

UniProtKB/Swiss-Prot:

ATS19_HUMAN :
  • Q8TE59
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 5 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS19: view

Function for ADAMTS19 Gene

Enzyme Numbers (IUBMB) for ADAMTS19 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS19: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS19

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS19 Gene

Localization for ADAMTS19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS19 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS19 Gene COMPARTMENTS Subcellular localization image for ADAMTS19 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS19: view

Pathways for ADAMTS19 Gene

SuperPathways for ADAMTS19 Gene

No Data Available

Interacting Proteins for ADAMTS19 Gene

Gene Ontology (GO) - Biological Process for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS19: view

No data available for Pathways by source for ADAMTS19 Gene

Transcripts for ADAMTS19 Gene

mRNA/cDNA for ADAMTS19 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS19 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS19

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAMTS19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS19 Gene

No ASD Table

Relevant External Links for ADAMTS19 Gene

GeneLoc Exon Structure for
ADAMTS19
ECgene alternative splicing isoforms for
ADAMTS19

Expression for ADAMTS19 Gene

mRNA expression in normal human tissues for ADAMTS19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS19 Gene

This gene is overexpressed in Uterus (8.7) and Cervix - Ectocervix (5.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS19 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS19 Gene Hs.23751

mRNA Expression by UniProt/SwissProt for ADAMTS19 Gene

Q8TE59-ATS19_HUMAN
Tissue specificity: Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library
genes like me logo Genes that share expressions with ADAMTS19: view

In Situ Assay Products

Orthologs for ADAMTS19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS19 35
  • 99.59 (n)
  • 99.59 (a)
ADAMTS19 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS19 35
  • 92.12 (n)
  • 94 (a)
ADAMTS19 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS19 35
  • 91.78 (n)
  • 93.48 (a)
ADAMTS19 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts19 35
  • 86.64 (n)
  • 87.8 (a)
Adamts19 16
Adamts19 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS19 35
  • 77.95 (n)
  • 81.42 (a)
ADAMTS19 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS19 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts19 35
  • 69.99 (n)
  • 72.9 (a)
Species with no ortholog for ADAMTS19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAMTS19 Gene

ENSEMBL:
Gene Tree for ADAMTS19 (if available)
TreeFam:
Gene Tree for ADAMTS19 (if available)

Paralogs for ADAMTS19 Gene

Selected SIMAP similar genes for ADAMTS19 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS19: view

Variants for ADAMTS19 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25801 -- 129,697,755(+) CCAGG(A/G)TCCTT intron-variant
rs25802 -- 129,696,088(+) CAGAC(A/G)AATGG intron-variant
rs25803 -- 129,692,920(+) TCTTG(C/T)CTATA intron-variant
rs25804 -- 129,691,611(+) ATGAG(A/T)TTTTT intron-variant
rs25805 -- 129,665,259(+) TTTTT(G/T)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS19 Gene

Variant ID Type Subtype PubMed ID
nsv882852 CNV Gain 21882294
dgv1849e1 CNV Complex 17122850
esv2752060 CNV Gain 17911159
nsv882857 CNV Loss 21882294
nsv830486 CNV Gain 17160897
nsv830487 CNV Loss 17160897
esv2664922 CNV Deletion 23128226
esv2671546 CNV Deletion 23128226
esv25215 CNV Loss 19812545
dgv1002e201 CNV Deletion 23290073
esv2730769 CNV Deletion 23290073
esv2730770 CNV Deletion 23290073
esv2730771 CNV Deletion 23290073
esv2663219 CNV Deletion 23128226
esv2675613 CNV Deletion 23128226
nsv823221 CNV Gain 20364138
nsv882858 CNV Loss 21882294
nsv5000 CNV Insertion 18451855
nsv882859 CNV Loss 21882294

Relevant External Links for ADAMTS19 Gene

HapMap Linkage Disequilibrium report
ADAMTS19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS19 Gene

Disorders for ADAMTS19 Gene

(1) University of Copenhagen DISEASES for ADAMTS19 Gene

Relevant External Links for ADAMTS19

Genetic Association Database (GAD)
ADAMTS19
Human Genome Epidemiology (HuGE) Navigator
ADAMTS19
genes like me logo Genes that share disorders with ADAMTS19: view

No data available for UniProtKB/Swiss-Prot for ADAMTS19 Gene

Publications for ADAMTS19 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S. … Lopez-Otin C. (Gene 2002) 2 3 4
  2. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. (PMID: 19508998) Knauff E.A. … Fauser B.C. (Hum. Reprod. 2009) 3 48
  3. Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression. (PMID: 22445761) Kurose K. … Saito Y. (Psychiatry Res 2012) 3 48
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3

Products for ADAMTS19 Gene

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Sources for ADAMTS19 Gene

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