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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAMTS18 Gene

protein-coding GIFtS: 53
GCID: GC16M077316

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
(Previous symbol: ADAMTS21)

Explore 18 diseases affiliated with
ADAMTS18 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 18¹ ²		Disintegrin And Metalloprotease-Like Protein²
ADAMTS21¹ ² ³		ADAM-TS18³
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 18¹ ²		ADAMTS-18³
KNO2²		EC 3.4.24.-³
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 18²		ADAM-TS 18³
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 21²		EC 3.4.24.82⁸

External Ids:	HGNC: 17110¹	Entrez Gene: 170692²	Ensembl: ENSG00000140873⁷	OMIM: 607512⁵	UniProtKB: Q8TE60³

Export aliases for ADAMTS18 gene to outside databases

Previous GC identifers: GC16M068256 GC16M078287 GC16M077065 GC16M077106 GC16M077095 GC16M075873 GC16M063072

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS18:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein

family. ADAMTS family members share several distinct protein modules, including a propeptide region, a

metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of

this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded

by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is

thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their

biological validity has not been determined. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAMTS18 gene promoter:
Pax-5 RREB-1 HNF-1A C/EBPalpha CHOP-10 MEF-2A MZF-1 Nkx6-1 HNF-1 aMEF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ADAMTS18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q23

ADAMTS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS18 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M077316: view genomic region (about GC identifiers)

Start:	77,281,710 bp from pter	End:	77,469,011 bp from pter
Size:	187,302 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATS18_HUMAN, Q8TE60 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor

Size: 1221 amino acids; 135167 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Sequence caution: Sequence=BAC85503.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAC83612.1; Type=Miscellaneous discrepancy; Note=Probable intron retention; Sequence=CAC83612.1;

Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q6P4R5 Q6ZWJ9

Alternative splicing: 2 isoforms: Q8TE60-1 Q8TE60-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMTS18: NX_Q8TE60

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence

C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the

repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose

residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.

Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence

W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TE60

2 DME Specific Peptides for ADAMTS18 (Q8TE60)

VETLVVAD

CSRTCGGGV

ADAMTS18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_955387.1

ENSEMBL proteins:

ENSP00000454368 ENSP00000282849 ENSP00000392540 ENSP00000457395

Human Recombinant Protein Products for ADAMTS18:

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	Uscn Proteins for ADAMTS18

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--

ADAMTS18 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAMTS18 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000884 Thrombospondin_1_rpt

IPR024079 MetalloPept_cat_dom

IPR010294 ADAM_spacer1

IPR010909 PLAC

IPR001590 Peptidase_M12B

Graphical View of Domain Structure for InterPro Entry Q8TE60

ProtoNet protein and cluster: Q8TE60

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS18_HUMAN, Q8TE60

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 1 PLAC domain

Similarity: Contains 5 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Numbers (IUBMB): EC 3.4.24.-¹ EC 3.4.24.82²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

ADAMTS18 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ADAMTS18:

Large cells

Synthetic lethal with Ras

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adamts18):

reproductive system

ADAMTS18 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTS18

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		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS18 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS18

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAMTS18

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ADAMTS18 (ENSP00000282849⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VEGFA	ENSP00000361125⁴	STRING: ENSP00000361125

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007229	integrin-mediated signaling pathway	--	--

ADAMTS18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAMTS18
Search CenterWatch for drugs/clinical trials and news about ADAMTS18 / ATS18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAMTS18 gene (2 alternative transcripts):

NM_199355.2 NM_139054.2

Unigene Cluster for ADAMTS18:

ADAM metallopeptidase with thrombospondin type 1 motif, 18

Hs.188746 [show with all ESTs]

Unigene Representative Sequence: NM_199355

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562332 ENST00000282849(uc010chc.1 uc002ffe.1 uc002ffc.4 uc010vni.1)

ENST00000568393 ENST00000449265 ENST00000562345 ENST00000567914 ENST00000567121

ENST00000564369 ENST00000569309

miRNA Products:		OriGene 3'-UTR Clone: ADAMTS18 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS18
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS18 (see all 61):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS18 3' UTR sequence

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Additional cDNA sequence:

AF086229.1 AJ311903.1 AK122677.1 AK131403.1 AK293831.1 AY172951.1 BC063283.1

6 DOTS entries:

DT.100654716 DT.102821110 DT.86855978 DT.440443 DT.100739731 DT.40315579

24/52 AceView cDNA sequences (see all 52):

AF086229 BE467873 Z41124 BM684970 Z45412 BC063283 BE551244 AA902183

BM931923 NM_199355 AA369130 BE467894 BE219281 NM_139054 AW444896 AK122677

W56603 CD636665 CD636667 AI890308 BX434008 AK131403 AI733120 AA632012

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS18 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^
SP1:					-				-		-								-
SP2:					-				-		-								-
SP3:									-		-								-
SP4:
SP5:											-								-

ExUns:	17a	·	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	^	24	^	25
SP1:									-										-
SP2:									-
SP3:									-				-		-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for ADAMTS18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAMTS18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTATAGAG

About this image

ADAMTS18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

Definitive endoderm-like cells (Generation and expan...)

Primitive gut tube-like cells (A scalable, suspensi...)

Cartilage-like cells (Differentiation of s...)

Cartilage

See ADAMTS18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAMTS18

SOURCE GeneReport for Unigene cluster: Hs.188746

UniProtKB/Swiss-Prot: ATS18_HUMAN, Q8TE60

Tissue specificity: Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and

endothelium

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS18 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	ADAMTS18¹	ADAM metallopeptidase with thrombospondin type 1 motif, more	74.11(n) 76.77(a)	100858277 XM_003641937.1 XP_003641985.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.13335²	Xenopus laevis transcribed sequence with weak similarity more	72.3(n)	BJ038710.1
zebrafish (Danio rerio)	Actinopterygii	adamts18¹	ADAM metallopeptidase with thrombospondin type 1 motif, more	65.89(n) 67.85(a)	100150128 XM_001919031.1 XP_001919066.1

ENSEMBL Gene Tree for ADAMTS18 (if available)
TreeFam Gene Tree for ADAMTS18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAMTS18 gene

ADAMTS7² ADAMTS17² ADAMTS1² ADAMTS19² ADAMTS6² ADAMTS12² ADAMTS14² ADAMTS2²

ADAMTS20² ADAMTS5² ADAMTS4² ADAMTS15² ADAMTS16² ADAMTS9² ADAMTS8² ADAMTS3²

ADAMTS10²

16 SIMAP similar genes for ADAMTS18 using alignment to 5 protein entries: ATS18_HUMAN (see all proteins):

ADAMTS16 ADAMTS12 ADAMTS6 ADAMTS1 DKFZp686E01144 ADAMTS10

ADAMTS20 ADAMTS19 ADAMTS9 ADAMTSL5 C9orf8 DKFZp434K1772

ADAMTS8 ADAMTS14 ADAMTS2 ADAMTS3

ADAMTS18 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56011164^1,2	C	--	63072797(+)	`AGCTGT/CCAAAG`	1	--	ut3¹		2		WA	120
rs115408000^1,2	C,F	--	63072939(+)	`AGAACA/CCATAA`	1	--	ut3¹		1		WA	118
rs74025765^1,2	C	--	63073098(+)	`CAAGCG/CAAGCA`	1	--	ut3¹		1		WA	2
rs73630433^1,2	C	--	63073805(+)	`ATTCCC/TAAAGA`	1	--	ut3¹		2		WA	120
rs3087939^1,2	H	--	63073816(-)	`CTACAG/ACCCGC`	1	--	ut3¹ ese³		5		MN NS EA	604
rs78203502^1,2	C,F	--	63074476(+)	`TACTGG/TCAACC`	1	--	ut3¹		1		WA	118
rs113598447^1,2	C	--	63075011(+)	`GGCCAG/AGCTGG`	1	--	int¹		1		WA	2
rs77529558^1,2		--	63075243(+)	`GGTAGA/GGGGGT`	1	--	int¹		0	--	--	--	--
rs16945442^1,2	C,F,H	--	63075278(+)	`CAAGAA/CAAGAC`	1	--	int¹		19		NA NS EA WA	1880
rs74413023^1,2	F	--	63075362(+)	`TCCCTA/GTGTAG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ADAMTS18 (77281710 - 77469011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADAMTS18
1 CNV: 9281
1 Indel: 25680
Human Gene Mutation Database (HGMD): ADAMTS18

1 SABiosciences Cancer Mutation PCR Assay for ADAMTS18:

Cosmic Id	AA Change
109444	p.P452S

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ADAMTS18 for disorders About GeneDecksing

OMIM gene information: 607512 OMIM disorders: --

UniProtKB/Swiss-Prot: ATS18_HUMAN, Q8TE60

Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2) [MIM:608454]. A developmental disorder

primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal

degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to

occult cutis aplasia

18 diseases for ADAMTS18: About MalaCards

carotid artery occlusion vitreoretinal degeneration encephalocele encephaloceles

knobloch syndrome retinal detachment myopia retinitis

nasopharyngitis pancreatic cancer breast cancer pancreatitis

cerebritis esophagitis cholesterol melanoma

prostatitis carcinoma

Human Genome Epidemiology (HuGE) Navigator: ADAMTS18 (5 documents)

Export disorders for ADAMTS18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAMTS18 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ADAMTS18)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)^{1, 2, 3} Cal S....Lopez-Otin C. (2002)
Identification of ADAMTS18 as a gene mutated in Knobloch syndrome. (PubMed id 21862674)^{1, 2} Aldahmesh M.A.... Alkuraya F.S. (2011)
Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas. (PubMed id 17546048)^{1, 3} Jin H....Tao Q. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. (PubMed id 19249006)^{1, 9} Xiong D.H....Deng H.W. (2009)
A genome-wide search for genetic influences and biolog ical pathways related to the brain's white matter integrity. (PubMed id 22425255)¹ Lopez L.M....Deary I.J. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Mutational and functional analysis reveals ADAMTS18 m etalloproteinase as a novel driver in melanoma. (PubMed id 21047771)¹ Wei X....Samuels Y. (2010)
Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)¹ Dastani Z....Genest J. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 170692	HGNC: 17110	AceView: ADAMTS18	Ensembl:ENSG00000140873	euGenes: HUgn170692
ECgene: ADAMTS18	H-InvDB: ADAMTS18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADAMTS18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAMTS18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADAMTS18 gene:
Search GeneIP for patents involving ADAMTS18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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