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ADAMTS17 Gene

protein-coding   GIFtS: 53
GCID: GC15M100511

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 171 2     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 172
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 171 2
     EC 3.4.24.-3
ADAM-TS172 3     EC 3.4.248
ADAMTS-172 3     EC 3.4.24.808
ADAM-TS 172 3     EC 3.4.24.828

External Ids:    HGNC: 171091   Entrez Gene: 1706912   Ensembl: ENSG000001404707   OMIM: 6075115   UniProtKB: Q8TE563   

Export aliases for ADAMTS17 gene to outside databases

Previous GC identifers: GC15M097199 GC15M094354 GC15M098105 GC15M098249 GC15M098332 GC15M076635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS17 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. ADAMTS family members share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member.
The function of this protein has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS17 Gene:
ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif, 17) is a protein-coding gene. Diseases associated with ADAMTS17 include weill-marchesani-like syndrome, and weill-marchesani syndrome. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS17 gene promoter:
         AhR   Pax-5   MyoD   CUTL1   Arnt   GATA-1   Max   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS17 promoter sequence
   Search Chromatin IP Primers for ADAMTS17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q24

ADAMTS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS17 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M100511:  view genomic region     (about GC identifiers)

Start:
100,511,643 bp from pter      End:
100,882,210 bp from pter
Size:
370,568 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATS17_HUMAN, Q8TE56 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 17 precursor  
Size: 1095 amino acids; 121127 Da
Secondary accessions: Q2I7G4 Q6ZN75
Alternative splicing: 2 isoforms:  Q8TE56-1   Q8TE56-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMTS17: NX_Q8TE56

Explore proteomics data for ADAMTS17 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn167, Asn483, Asn785, Asn790, Asn832, Asn839, Asn894
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ADAMTS17 (Q8TE56)
     EDRCGVC  HELGHNLG  VETLVVAD  VLPVLLLL 


    See ADAMTS17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620688.2  
    ENSEMBL proteins: 
     ENSP00000268070   ENSP00000456161   ENSP00000453604   ENSP00000458005  
    Reactome Protein details: Q8TE56

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS17
    ADAMTS family

    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010909 PLAC
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry Q8TE56

    ProtoNet protein and cluster: Q8TE56

    4 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: ATS17_HUMAN, Q8TE56
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 5 TSP type-1 domains


    ADAMTS17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    ADAMTS17 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-7-5p (MIRT025745)

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    Selected qRT-PCR Assays for microRNAs that regulate ADAMTS17 (see all 48):
    hsa-miR-548j hsa-miR-3164 hsa-miR-607 hsa-miR-4272 hsa-miR-29a hsa-miR-134 hsa-miR-507 hsa-miR-105
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS17_HUMAN, Q8TE56: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTS17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAMTS17
        O-glycosylation of TSR domain-containing proteins



    ADAMTS17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS17
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS17

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    ADAMTS17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS17 (ATS17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAMTS17 gene: 
    NM_139057.2  

    Unigene Cluster for ADAMTS17:

    ADAM metallopeptidase with thrombospondin type 1 motif, 17
    Hs.513200  [show with all ESTs]
    Unigene Representative Sequence: NM_139057
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268070(uc002bvv.1) ENST00000557896(uc002bvw.1) ENST00000568565
    ENST00000378898(uc002bvx.1) ENST00000559976 ENST00000560486 ENST00000558960
    ENST00000561355 ENST00000558930
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAMTS17 (see all 48):
    hsa-miR-548j hsa-miR-3164 hsa-miR-607 hsa-miR-4272 hsa-miR-29a hsa-miR-134 hsa-miR-507 hsa-miR-105
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AJ315735.1 AK057331.1 AK057529.1 AK131344.1 

    5 DOTS entries:

    DT.97812320  DT.102836411  DT.75106238  DT.102836410  DT.75143484 

    Selected AceView cDNA sequences (see all 28):

    AK057331 AA022668 NM_139057 AA884550 BQ053458 AJ315735 BP357317 AK131344 
    AK057529 BM918902 BQ005455 CD636699 BI497386 CD636703 AI808729 CD636701 
    AW303283 AI701673 CD636697 CD636707 BF529318 AJ572237 CD710368 CD636705 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS17 expression in normal human tissues (normalized intensities)      ADAMTS17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAMTS17 Expression
    About this image


    ADAMTS17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    ADAMTS17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513200

    UniProtKB/Swiss-Prot: ATS17_HUMAN, Q8TE56
    Tissue specificity: Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina.
    Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression
    in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal
    heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS17 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts171 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 86.23(n)1
    90.21(a)1
      7 (36.26 cM)5
    2333321  NM_001033877.41  NP_001029049.21 
     668397355 
    chicken
    (Gallus gallus)
    Aves ADAMTS171 ADAM metallopeptidase with thrombospondin type 1 motif, more 76.54(n)
    82.11(a)
      415515  XM_413886.4  XP_413886.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS176
    ADAM metallopeptidase with thrombospondin type 1 m...
    78(a)
    1 ↔ 1
    GL343383.1(521843-680205)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts171 ADAM metallopeptidase with thrombospondin type 1 motif, more 72.18(n)
    77.89(a)
      100380150  XM_004912664.1  XP_004912721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018841201 A disintegrin and metalloproteinase with thrombospondin more 69.37(n)
    72.38(a)
      101884120  XM_005170768.1  XP_005170825.1 


    ENSEMBL Gene Tree for ADAMTS17 (if available)
    TreeFam Gene Tree for ADAMTS17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS17 gene
    ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    3 SIMAP similar genes for ADAMTS17 using alignment to 4 protein entries:     ATS17_HUMAN (see all proteins):
    ADAMTS19    ADAMTS13    ADAMTS12

    ADAMTS17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS17 (see all 11543)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409249731,2
    --80236401(+) GTCTGC/TAGTGC 1 -- ds50010--------
    rs8726101,2
    C,F,A,H--80236425(-) AGTCCC/TGGCCC 1 -- ds500112Minor allele frequency- T:0.15NS EA NA WA 924
    rs1853437361,2
    --80236435(+) TTGCCA/GTCACA 1 -- ds50010--------
    rs1447969441,2
    --80236449(+) GCTGGC/TAGAGG 1 -- ds50010--------
    rs1479256541,2
    --80236532(+) CCAGCA/GTGGCC 1 -- ds50010--------
    rs1490663721,2
    --80236586(+) CTGCCA/CGTGAG 1 -- ds50010--------
    rs133295771,2
    C,F,H--80236614(+) GATGCG/ACAGGC 1 -- ds50015Minor allele frequency- A:0.01NS EA WA 528
    rs765308361,2
    F--80236740(+) CCCCCC/TGAACT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs104681821,2
    C,F,H--80237093(+) ATAGAT/CACATT 1 -- ut315Minor allele frequency- C:0.00NS EA WA 538
    rs1897023781,2
    --80237111(+) GAAACA/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAMTS17 (100511643 - 100761643 bp, first 250kb of ADAMTS17)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAMTS17 (see all 61):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750128CNV Deletion23290073
    esv2750132CNV Deletion23290073
    esv1039633CNV Deletion17803354
    esv2042603CNV Deletion18987734
    esv2664256CNV Deletion23128226
    esv2750133CNV Deletion23290073
    esv2659830CNV Deletion23128226
    esv2750127CNV Deletion23290073
    esv2656457CNV Deletion23128226
    esv2750126CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ADAMTS17
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS17
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607511   
    OMIM disorders: 613195  
    UniProtKB/Swiss-Prot: ATS17_HUMAN, Q8TE56
  • Weill-Marchesani-like syndrome (WMLS) [MIM:613195]: A disorder characterized by many of the key features
    of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short
    stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome
    are absent. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 10 diseases for ADAMTS17:    About MalaCards
    weill-marchesani-like syndrome    weill-marchesani syndrome    brachydactyly    myopia
    short stature    glaucoma    myocardial infarction    multiple myeloma
    myeloma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ADAMTS17:
    Weill-Marchesani syndrome

    ADAMTS17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS17
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS17 (4 documents)

    Export disorders for ADAMTS17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS17 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ADAMTS17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2, 3 Cal S....Lopez-Otin C. (Gene 2002)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    4. Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. (PubMed id 19836009)1, 2 Morales J....Al Tassan N. (Am. J. Hum. Genet. 2009)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    8. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. (PubMed id 23661674)1 Boulaftali Y....Bouton M.C. (Arterioscler. Thromb. Vasc. Biol. 2013)
    9. Genome-wide association study identifies two susceptibility loci for osteosarcoma. (PubMed id 23727862)1 Savage S.A....Chanock S.J. (Nat. Genet. 2013)
    10. Familial spherophakia with short stature caused by a novel homozygous ADAMTS17 mutation. (PubMed id 22486325)1 Khan A.O....Alkuraya F.S. (Ophthalmic Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170691 HGNC: 17109 AceView: ADAMTS17 Ensembl:ENSG00000140470 euGenes: HUgn170691
    ECgene: ADAMTS17 H-InvDB: ADAMTS17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS17 gene:
    Search GeneIP for patents involving ADAMTS17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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