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Aliases for ADAMTS16 Gene

Aliases for ADAMTS16 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 16 2 3
  • ADAM-TS 16 3 4
  • ADAM-TS16 3 4
  • ADAMTS-16 3 4
  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 16 3
  • EC 3.4.24.- 4
  • ADAMTS16s 3
  • KIAA2029 4

External Ids for ADAMTS16 Gene

Previous GeneCards Identifiers for ADAMTS16 Gene

  • GC05P005281
  • GC05P005173
  • GC05P005193
  • GC05P005113

Summaries for ADAMTS16 Gene

Entrez Gene Summary for ADAMTS16 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS16 Gene

ADAMTS16 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16) is a Protein Coding gene. Among its related pathways are Infectious disease and Diseases associated with O-glycosylation of proteins. GO annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS16 Gene

Genomics for ADAMTS16 Gene

Regulatory Elements for ADAMTS16 Gene

Enhancers for ADAMTS16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS16 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS16 Gene

5,140,330 bp from pter
5,320,304 bp from pter
179,975 bases
Plus strand

Genomic View for ADAMTS16 Gene

Genes around ADAMTS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS16 Gene

Proteins for ADAMTS16 Gene

  • Protein details for ADAMTS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 16
    Protein Accession:
    Secondary Accessions:
    • C6G490
    • Q8IVE2

    Protein attributes for ADAMTS16 Gene

    1224 amino acids
    Molecular mass:
    136203 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS16 Gene


neXtProt entry for ADAMTS16 Gene

Proteomics data for ADAMTS16 Gene at MOPED

Post-translational modifications for ADAMTS16 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 156, Asn 310, Asn 741, Asn 780, Asn 835, Asn 905, and Asn 935
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTS16 Gene

Domains & Families for ADAMTS16 Gene

Gene Families for ADAMTS16 Gene

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 6 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS16: view

Function for ADAMTS16 Gene

Enzyme Numbers (IUBMB) for ADAMTS16 Gene

genes like me logo Genes that share phenotypes with ADAMTS16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS16

miRNA for ADAMTS16 Gene

miRTarBase miRNAs that target ADAMTS16

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS16 Gene

Localization for ADAMTS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTS16 Gene COMPARTMENTS Subcellular localization image for ADAMTS16 gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ADAMTS16 Gene

Pathways & Interactions for ADAMTS16 Gene

genes like me logo Genes that share pathways with ADAMTS16: view

Interacting Proteins for ADAMTS16 Gene

Selected Interacting proteins: Q8TE57-ATS16_HUMAN for ADAMTS16 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view

No data available for SIGNOR curated interactions for ADAMTS16 Gene

Drugs & Compounds for ADAMTS16 Gene

No Compound Related Data Available

Transcripts for ADAMTS16 Gene

Unigene Clusters for ADAMTS16 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS16 Gene

No ASD Table

Relevant External Links for ADAMTS16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS16 Gene

mRNA expression in normal human tissues for ADAMTS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS16 Gene

This gene is overexpressed in Ovary (x11.6), Brain - Cerebellum (x10.4), and Brain - Cerebellar Hemisphere (x9.6).

Protein differential expression in normal tissues from HIPED for ADAMTS16 Gene

This gene is overexpressed in Colon muscle (43.8), Bone (16.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS16 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS16 Gene Hs.661915

mRNA Expression by UniProt/SwissProt for ADAMTS16 Gene

Tissue specificity: Expressed in fetal lung and kidney and in adult prostate and ovary.
genes like me logo Genes that share expression patterns with ADAMTS16: view

Protein tissue co-expression partners for ADAMTS16 Gene

Primer Products

Orthologs for ADAMTS16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS16 35
  • 82.63 (n)
  • 83.47 (a)
  • 83 (a)
(Canis familiaris)
Mammalia ADAMTS16 35
  • 84.78 (n)
  • 85.49 (a)
  • 87 (a)
(Mus musculus)
Mammalia Adamts16 35
  • 80.62 (n)
  • 82.32 (a)
Adamts16 16
Adamts16 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADAMTS16 35
  • 99.19 (n)
  • 99.35 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Adamts16 35
  • 80.76 (n)
  • 81.25 (a)
(Monodelphis domestica)
Mammalia ADAMTS16 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS16 36
  • 77 (a)
(Anolis carolinensis)
Reptilia ADAMTS16 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts16 35
  • 69.45 (n)
  • 70.3 (a)
(Danio rerio)
Actinopterygii adamts16 35
  • 65.32 (n)
  • 64.5 (a)
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3622 37
  • 28 (a)
CG14869 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C37C3.6a 37
  • 32 (a)
C37C3.6b 37
  • 32 (a)
T19D2.1 37
  • 31 (a)
gon-1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for ADAMTS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS16 Gene

Gene Tree for ADAMTS16 (if available)
Gene Tree for ADAMTS16 (if available)

Paralogs for ADAMTS16 Gene

genes like me logo Genes that share paralogs with ADAMTS16: view

Variants for ADAMTS16 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1863968 - 5,146,282(-) ATCCA(C/T)GTGGA reference, missense
rs16875054 - 5,209,097(+) GCACC(A/G)CTCAA reference, missense
rs9313105 - 5,239,767(+) CTGTG(C/T)GCAAT reference, missense
rs16875122 - 5,242,105(+) GCCTC(A/G/T)CTTGG reference, missense
rs35394775 - 5,242,116(-) CTTCT(C/T)GGTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS16 Gene

Variant ID Type Subtype PubMed ID
dgv1748e1 CNV Complex 17122850
nsv830194 CNV Gain 17160897
nsv4691 CNV Insertion 18451855
esv25455 CNV Loss 19812545
nsv526817 CNV Loss 19592680
esv269786 CNV Insertion 20981092
esv2729670 CNV Deletion 23290073
esv2729671 CNV Deletion 23290073
esv5491 CNV Loss 19470904
esv2729672 CNV Deletion 23290073
esv2729674 CNV Deletion 23290073

Variation tolerance for ADAMTS16 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.35; 97.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS16 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS16 Gene

Disorders for ADAMTS16 Gene

Relevant External Links for ADAMTS16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADAMTS16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS16 Gene

Publications for ADAMTS16 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S. … Lopez-Otin C. (Gene 2002) 2 3 4 67
  2. Positional identification of variants of Adamts16 linked to inherited hypertension. (PMID: 19423552) Joe B. … Bouchard C. (Hum. Mol. Genet. 2009) 3 23
  3. Characterization and regulation of ADAMTS-16. (PMID: 19635554) Surridge A.K. … Clark I.M. (Matrix Biol. 2009) 3 23
  4. A genome-wide scan for breast cancer risk haplotypes among African American women. (PMID: 23468962) Song C. … Stram D.O. (PLoS ONE 2013) 3
  5. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PMID: 24039173) McGrath L.M. … Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3

Products for ADAMTS16 Gene

Sources for ADAMTS16 Gene