Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADAMTS16 Gene

protein-coding   GIFtS: 55
GCID: GC05P005140

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 161 2     ADAMTS16s2
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 161 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 162
ADAM-TS162 3     EC 3.4.24.-3
ADAMTS-162 3     KIAA20293
ADAM-TS 162 3     

External Ids:    HGNC: 171081   Entrez Gene: 1706902   Ensembl: ENSG000001455367   OMIM: 6075105   UniProtKB: Q8TE573   

Export aliases for ADAMTS16 gene to outside databases

Previous GC identifers: GC05P005281 GC05P005173 GC05P005193 GC05P005113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADAMTS16 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. ADAMTS family members share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS16 Gene:
ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif, 16) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS16 gene promoter:
         AML1a   NCX/Ncx   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   Nkx5-1   E47   RORalpha1   Pax-3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS16 promoter sequence
   Search Chromatin IP Primers for ADAMTS16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15   Ensembl cytogenetic band:  5p15.32   HGNC cytogenetic band: 5p15

ADAMTS16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS16 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P005140:  view genomic region     (about GC identifiers)

Start:
5,140,443 bp from pter      End:
5,320,417 bp from pter
Size:
179,975 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATS16_HUMAN, Q8TE57 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 16 precursor  
Size: 1224 amino acids; 136203 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: C6G490 Q8IVE2
Alternative splicing: 2 isoforms:  Q8TE57-1   Q8TE57-2   

Explore the universe of human proteins at neXtProt for ADAMTS16: NX_Q8TE57

Explore proteomics data for ADAMTS16 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn156, Asn310, Asn741, Asn780, Asn835, Asn905, Asn935
  • Modification sites at PhosphoSitePlus

  • See ADAMTS16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620687.2  
    ENSEMBL proteins: 
     ENSP00000421631   ENSP00000274181  
    Reactome Protein details: Q8TE57

    ADAMTS16 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAMTS16
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAMTS16
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS16
    Novus Biologicals ADAMTS16 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMTS16

     
    Search eBioscience for Proteins for ADAMTS16 

    ADAMTS16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADAMTS16
    OriGene Custom Antibody Services for ADAMTS16
    Abcam antibodies for ADAMTS16
    Cloud-Clone Corp. Antibodies for ADAMTS16
    Search ThermoFisher Antibodies for ADAMTS16
    Search LSBio for Antibodies for ADAMTS16

    ADAMTS16 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAMTS16
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTS16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAMTS16
    Cloud-Clone Corp. CLIAs for ADAMTS16
    Search eBioscience for ELISAs for ADAMTS16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS16
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010909 PLAC
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry Q8TE57

    ProtoNet protein and cluster: Q8TE57

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS16_HUMAN, Q8TE57
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 6 TSP type-1 domains


    Find genes that share domains with ADAMTS16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAMTS16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS16

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADAMTS16:
    hsa-mir-335-5p (MIRT018023)

    Block miRNA regulation of human, mouse, rat ADAMTS16 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ADAMTS16:
    hsa-miR-3163 hsa-miR-548a-3p hsa-miR-4291 hsa-miR-548e hsa-miR-545 hsa-miR-340 hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAMTS16
    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS16

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAMTS16

    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS16 (see all 7)
    OriGene ORF clones in mouse, rat for ADAMTS16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAMTS16 (NM_139056)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS16

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAMTS16
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAMTS16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATS16_HUMAN, Q8TE57: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with ADAMTS16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADAMTS16 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with ADAMTS16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ADAMTS16
        O-glycosylation of TSR domain-containing proteins
    Degradation of the extracellular matrix


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS16
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ADAMTS16 (Q8TE573 ENSP000002741814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAEAQ7L5Y93I2D: score=4 
    PDIA4ENSP000002860914STRING: ENSP00000286091
    --ENSP000002787524STRING: ENSP00000278752
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with ADAMTS16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS16 (ATS16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADAMTS16 gene: 
    NM_139056.2  

    Unigene Cluster for ADAMTS16:

    ADAM metallopeptidase with thrombospondin type 1 motif, 16
    Hs.661915  [show with all ESTs]
    Unigene Representative Sequence: NM_139056
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511368(uc003jdj.1) ENST00000274181(uc003jdk.1 uc003jdl.3)
    ENST00000433402(uc010itk.1) ENST00000513709
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADAMTS16 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ADAMTS16:
    hsa-miR-3163 hsa-miR-548a-3p hsa-miR-4291 hsa-miR-548e hsa-miR-545 hsa-miR-340 hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADAMTS16
    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS16
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS16 (see all 7)
    OriGene ORF clones in mouse, rat for ADAMTS16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAMTS16 (NM_139056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS16
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS16
      QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS16
      QuantiFast Probe-based Assays in human, mouse, rat ADAMTS16

    Additional mRNA sequence: 

    AB095949.1 AK122980.1 AK127746.1 AM983533.1 DQ266047.1 

    4 DOTS entries:

    DT.435993  DT.97836751  DT.70102829  DT.101977476 

    Selected AceView cDNA sequences (see all 32):

    AW236577 AB095949 BM845044 BX112729 NM_139056 BM850160 AI969349 BM845406 
    BM808410 CD636683 CD636673 BM844919 BE645050 AA341442 AI740544 AK122980 
    AJ315734 AK127746 CD636681 AA716087 BM906555 AI823432 CD636677 CD636675 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADAMTS16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAMTS16 Expression
    About this image


    ADAMTS16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    ADAMTS16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661915

    UniProtKB/Swiss-Prot: ATS16_HUMAN, Q8TE57
    Tissue specificity: Expressed in fetal lung and kidney and in adult prostate and ovary

        Custom PCR Arrays for ADAMTS16
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS16
    QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS16
    QuantiFast Probe-based Assays in human, mouse, rat ADAMTS16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS16 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts161 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 80.62(n)1
    82.32(a)1
      13 (35.97 cM)5
    2711271  NM_172053.21  NP_742050.21 
     707278025 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS166
    ADAM metallopeptidase with thrombospondin type 1 m...
    70(a)
    1 ↔ 1
    GL343211.1(2837912-2956975)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts161 ADAM metallopeptidase with thrombospondin type 1 motif, more 69.45(n)
    70.3(a)
      100498052  XM_002935133.2  XP_002935179.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adamts161 ADAM metallopeptidase with thrombospondin type 1 motif, more 65.32(n)
    64.5(a)
      568792  XM_001922411.4  XP_001922446.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36223 metalloendopeptidase 28(a)   59B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C37C3.6a3 protease inhibitor 32(a)
    (best of 3)
      V(7829899-7835944)   --


    ENSEMBL Gene Tree for ADAMTS16 (if available)
    TreeFam Gene Tree for ADAMTS16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADAMTS16 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS52  ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS32  ADAMTS102  
    14 SIMAP similar genes for ADAMTS16 using alignment to 4 protein entries:     ATS16_HUMAN (see all proteins):
    ADAMTS18    PAPLN    ADAMTSL4    ADAMTSL1    ADAMTS12    ADAMTS6
    ADAMTS7    ADAMTS9    ADAMTS10    DKFZp434K1772    ADAMTS1    DKFZp686E01144
    ADAMTS20    ADAMTS4

    Find genes that share paralogs with ADAMTS16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADAMTS16 (see all 4496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877429041,2
    C--5138466(+) CAATCA/C/GATACT 1 -- us2k10--------
    rs1926057931,2
    --5138468(+) ATCGAC/TACTCT 1 -- us2k10--------
    rs1835699061,2
    --5138542(+) ATCTGA/GTGGGG 1 -- us2k10--------
    rs2702141,2
    C,A,H--5138580(-) tttacA/Catccc 1 -- us2k12Minor allele frequency- C:0.38NA NS 190
    rs111340931,2
    C,F,A,H--5138741(+) ttttgC/Tttttt 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs709659241,2
    C--5138773(+) TTTTT-/T/TTTT
            
    GAGAC
    1 -- us2k12NA 4
    rs131748871,2
    C,F--5138866(+) agctcC/Tgcctc 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs1112387581,2
    C--5138881(+) GTTCAC/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1999776311,2
    C--5138926(+) CAGGCA/GCCCGC 1 -- us2k10--------
    rs2702131,2
    C--5138943(-) attagA/Ccgggc 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAMTS16 (5140443 - 5320417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAMTS16 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729674CNV Deletion23290073
    esv2729671CNV Deletion23290073
    esv2729670CNV Deletion23290073
    esv2729672CNV Deletion23290073
    nsv4691CNV Insertion18451855
    esv269786CNV Insertion20981092
    nsv526817CNV Loss19592680
    esv25455CNV Loss19812545
    esv5491CNV Loss19470904
    nsv830194CNV Gain17160897

    Human Gene Mutation Database (HGMD): ADAMTS16
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS16
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607510    OMIM disorders: --


    Find genes that share disorders with ADAMTS16           About GenesLikeMe

    Genetic Association Database (GAD): ADAMTS16
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS16 (1 document)

    Export disorders for ADAMTS16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADAMTS16 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ADAMTS16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2, 3 Cal S....Lopez-Otin C. (Gene 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Characterization and regulation of ADAMTS-16. (PubMed id 19635554)1, 9 Surridge A.K....Clark I.M. (Matrix Biol. 2009)
    4. Positional identification of variants of Adamts16 linked to inherited hypertension. (PubMed id 19423552)1, 9 Joe B....Bouchard C. (Hum. Mol. Genet. 2009)
    5. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PubMed id 24039173)1 McGrath L.M....Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    6. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. (PubMed id 22562232)1 Boeuf S....Richter W. (amp 2012)
    7. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    8. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PubMed id 18057069)4 Cronin S....Hardiman O. (Hum. Mol. Genet. 2008)
    9. FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles. (PubMed id 17519324)1 Gao S.... Zhang H. (Mol. Hum. Reprod. 2007)
    10. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. (PubMed id 16507336)1 Zeng W....Flannery C.R. (Biochim. Biophys. Acta 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 170690 HGNC: 17108 AceView: ADAMTS16 Ensembl:ENSG00000145536 euGenes: HUgn170690
    ECgene: ADAMTS16 H-InvDB: ADAMTS16

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA2029

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADAMTS16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAMTS16 gene:
    Search GeneIP for patents involving ADAMTS16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADAMTS16   OriGene RNAi products in human, mouse, rat for ADAMTS16  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ADAMTS16  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAMTS16  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS16   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAMTS16   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS16   OriGene Custom Protein Services for ADAMTS16  

     
     
     Block miRNA regulation of human, mouse, rat ADAMTS16 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAMTS16
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS16 Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS16
     QuantiFast Probe-based Assays in human, mouse, rat ADAMTS16 QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS16
     Custom PCR Arrays for ADAMTS16 Search Chromatin IP Primers for ADAMTS16
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS16  Search GeneGlobe Interaction Network for ADAMTS16
     Regulatory tfbs in ADAMTS16 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS16 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS16
     GenScript Custom Assay Services for ADAMTS16 GenScript Custom overexpressing Cell Line Services for ADAMTS16
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ADAMTS16 (ATS16)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADAMTS16 lysates
     Antibodies for ADAMTS16
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ADAMTS16
     Antibodies for ADAMTS16
     ELISAs for ADAMTS16
     CLIAs for ADAMTS16



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADAMTS16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS16
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS16
     SwitchGear Promoter luciferase reporter plasmids for ADAMTS16
     Search ThermoFisher Antibodies for ADAMTS16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS16
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS16
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAMTS16
     Search LSBio for Antibodies for ADAMTS16
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ADAMTS16
      Search eBioscience for proteins for ADAMTS16
      Search eBioscience for elisas for ADAMTS16
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAMTS16 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4