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Aliases for ADAMTS16 Gene

Aliases for ADAMTS16 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 16 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 16 2 3
  • ADAM-TS 16 3 4
  • ADAM-TS16 3 4
  • ADAMTS-16 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 16 3
  • EC 3.4.24.- 4
  • ADAMTS16s 3
  • KIAA2029 4

External Ids for ADAMTS16 Gene

Summaries for ADAMTS16 Gene

Entrez Gene Summary for ADAMTS16 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS16 Gene

ADAMTS16 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 16) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS16 Gene

Genomics for ADAMTS16 Gene

Genomic Location for ADAMTS16 Gene

Start:
5,140,330 bp from pter
End:
5,320,304 bp from pter
Size:
179,975 bases
Orientation:
Plus strand

Genomic View for ADAMTS16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS16 Gene

Regulatory Elements for ADAMTS16 Gene

Proteins for ADAMTS16 Gene

  • Protein details for ADAMTS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE57-ATS16_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 16
    Protein Accession:
    Q8TE57
    Secondary Accessions:
    • C6G490
    • Q8IVE2

    Protein attributes for ADAMTS16 Gene

    Size:
    1224 amino acids
    Molecular mass:
    136203 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS16 Gene

Proteomics data for ADAMTS16 Gene at MOPED

Post-translational modifications for ADAMTS16 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn156, Asn310, Asn741, Asn780, Asn835, Asn905, and Asn935

Other Protein References for ADAMTS16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTS16 Gene

Domains for ADAMTS16 Gene

Gene Families for ADAMTS16 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

UniProtKB/Swiss-Prot:

ATS16_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.:
    • Q8TE57
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q8TE57
  • Contains 1 disintegrin domain.:
    • Q8TE57
  • Contains 1 peptidase M12B domain.:
    • Q8TE57
  • Contains 1 PLAC domain.:
    • Q8TE57
  • Contains 6 TSP type-1 domains.:
    • Q8TE57
genes like me logo Genes that share domains with ADAMTS16: view

Function for ADAMTS16 Gene

Enzyme Numbers (IUBMB) for ADAMTS16 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view

miRNA for ADAMTS16 Gene

miRTarBase miRNAs that target ADAMTS16

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAMTS16 Gene

Localization for ADAMTS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS16 Gene COMPARTMENTS Subcellular localization image for ADAMTS16 gene
Compartment Confidence
extracellular 3
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS16: view

Pathways for ADAMTS16 Gene

genes like me logo Genes that share pathways with ADAMTS16: view

Pathways by source for ADAMTS16 Gene

Interacting Proteins for ADAMTS16 Gene

Selected Interacting proteins: Q8TE57-ATS16_HUMAN for ADAMTS16 Gene via I2D

Symbol External ID(s) Details
MAEA

Gene Ontology (GO) - Biological Process for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view

Transcripts for ADAMTS16 Gene

Unigene Clusters for ADAMTS16 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS16 Gene

No ASD Table

Relevant External Links for ADAMTS16 Gene

GeneLoc Exon Structure for
ADAMTS16
ECgene alternative splicing isoforms for
ADAMTS16

Expression for ADAMTS16 Gene

mRNA expression in normal human tissues for ADAMTS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS16 Gene

This gene is overexpressed in Ovary (11.6), Brain - Cerebellum (10.4), and Brain - Cerebellar Hemisphere (9.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMTS16 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS16 Gene Hs.661915

mRNA Expression by UniProt/SwissProt for ADAMTS16 Gene

Q8TE57-ATS16_HUMAN
Tissue specificity: Expressed in fetal lung and kidney and in adult prostate and ovary
genes like me logo Genes that share expressions with ADAMTS16: view

Orthologs for ADAMTS16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS16 36
  • 99.19 (n)
  • 99.35 (a)
ADAMTS16 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS16 36
  • 82.63 (n)
  • 83.47 (a)
ADAMTS16 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS16 36
  • 84.78 (n)
  • 85.49 (a)
ADAMTS16 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts16 36
  • 80.62 (n)
  • 82.32 (a)
Adamts16 16
Adamts16 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS16 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS16 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts16 36
  • 80.76 (n)
  • 81.25 (a)
lizard
(Anolis carolinensis)
Reptilia ADAMTS16 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts16 36
  • 69.45 (n)
  • 70.3 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts16 36
  • 65.32 (n)
  • 64.5 (a)
ADAMTS16 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14869 37
  • 20 (a)
OneToMany
CG3622 38
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea gon-1 37
  • 18 (a)
OneToMany
T19D2.1 38
  • 31 (a)
C37C3.6a 38
  • 32 (a)
C37C3.6b 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for ADAMTS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS16 Gene

ENSEMBL:
Gene Tree for ADAMTS16 (if available)
TreeFam:
Gene Tree for ADAMTS16 (if available)

Paralogs for ADAMTS16 Gene

genes like me logo Genes that share paralogs with ADAMTS16: view

Variants for ADAMTS16 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs187939 -- 5,144,033(-) tcaac(C/T)tgcca intron-variant
rs270177 -- 5,166,887(-) GATGC(A/T)GTAAG intron-variant
rs270178 -- 5,165,302(-) ggggc(A/G)ccgct intron-variant
rs270179 -- 5,165,220(-) gaagc(C/T)ggagc intron-variant
rs270180 -- 5,164,700(-) gactc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS16 Gene

Variant ID Type Subtype PubMed ID
dgv1748e1 CNV Complex 17122850
nsv830194 CNV Gain 17160897
nsv4691 CNV Insertion 18451855
esv25455 CNV Loss 19812545
nsv526817 CNV Loss 19592680
esv269786 CNV Insertion 20981092
esv2729670 CNV Deletion 23290073
esv2729671 CNV Deletion 23290073
esv5491 CNV Loss 19470904
esv2729672 CNV Deletion 23290073
esv2729674 CNV Deletion 23290073

Relevant External Links for ADAMTS16 Gene

HapMap Linkage Disequilibrium report
ADAMTS16
Human Gene Mutation Database (HGMD)
ADAMTS16

Disorders for ADAMTS16 Gene

Relevant External Links for ADAMTS16

Genetic Association Database (GAD)
ADAMTS16
Human Genome Epidemiology (HuGE) Navigator
ADAMTS16
genes like me logo Genes that share disorders with ADAMTS16: view

No data available for UniProtKB/Swiss-Prot for ADAMTS16 Gene

Publications for ADAMTS16 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S. … Lopez-Otin C. (Gene 2002) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Positional identification of variants of Adamts16 linked to inherited hypertension. (PMID: 19423552) Joe B. … Bouchard C. (Hum. Mol. Genet. 2009) 3 23
  4. Characterization and regulation of ADAMTS-16. (PMID: 19635554) Surridge A.K. … Clark I.M. (Matrix Biol. 2009) 3 23
  5. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. (PMID: 22562232) Boeuf S. … Richter W. (Eur Cell Mater 2012) 3

Products for ADAMTS16 Gene

Sources for ADAMTS16 Gene

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