ADAMTS15 Gene
protein-coding GIFtS : 47
GC11P129824
ADAM metallopeptidase with thrombospondin type 1 motif, 15 (Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for ADAMTS15
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ADAM-TS15 3 ADAMTS-15 3 EC 3.4.24.- 3 MGC126403 2
Descriptions ADAM metallopeptidase with thrombospondin type 1 motif, 15 2 ADAM-TS 15 3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 1 , 2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein 2 metalloprotease disintegrin 15 with thrombospondin domains 2
Search outside databases for aliases for ADAMTS15 genePrevious GC identifers: GC11P132319 GC11P131831 GC11P130352 GC11P129856
Summaries for ADAMTS15 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ADAMTS15 : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondinmotifs) protein family. ADAMTS family members share several distinct protein modules, including apropeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondintype 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,and some have unique C-terminal domains. The protein encoded by this gene has a high sequencesimilarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq]
Genomic Location for ADAMTS15
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ADAMTS15 gene Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q25 ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P129824:
(about GC identifiers )
Start:
129,824,079 bp from pter
End:
129,848,926 bp from pter
Size:
24,848 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000011.8 NT_033899.7 Proteins for ADAMTS15
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 (See
protein sequence )Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor Size : 950 amino acids; 103287 Da
Cofactor : Binds 1 zinc ion per subunit (By similarity)
Subcellular location : Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions : Q32MI6
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
REFSEQ proteins: NP_620686.1 ENSEMBL proteins: ENSP00000299164 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0005578 proteinaceous extracellular matrix
IEA --
About this table Antibodies for ADAMTS15: Assays for ADAMTS15:
Protein
Domains/ Families for ADAMTS15(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8TE58 ProtoNet protein and cluster: Q8TE58
5 Blocks protein families : IPB000884 Thrombospondin IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB008085 Thrombospondin type 1 repeat signature IPB010294 ADAM-TS Spacer 1 UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 Domain : The spacer domain and the TSP type-1 domains are important for a tight interaction with theextracellular matrix (By similarity) Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon theactivation-peptide release activates the enzyme Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 peptidase M12B domainSimilarity : Contains 3 TSP type-1 domains
Gene Function for ADAMTS15
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139055 Applied Biosystems Silencer ® siRNAs for ADAMTS15 Sigma-Aldrich siRNA and siRNA Panels for ADAMTS15 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS15 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_139055                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_139055                                  untagged cDNA clone in CMV expression vector: NM_139055  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_139055 4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for ADAMTS15
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006508 proteolysis
IEA --
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Drugs & Compounds for ADAMTS15 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for ADAMTS15
Browse Tocris compounds for ADAMTS15
Transcripts for ADAMTS15(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139055 Sigma-Aldrich siRNA and siRNA Panels for ADAMTS15 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS15 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_139055
REFSEQ mRNAs for ADAMTS15 gene: NM_139055.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_139055
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_139055                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_139055                                  untagged cDNA clone in CMV expression vector: NM_139055  
Additional cDNA sequence: AJ315733.1 AK123049.1 BC109114.1
2 DOTS entries : DT.101975133 DT.97822376
3 AceView cDNA sequences :NM_139055 AJ315733 CF994242
highest scoring ESTs for ADAMTS15 :AJ315733 CN285485 NM_139055 BC109114 CN348315 CN348316 AA249879 AA298709 AA463893 AA740671
Unigene Cluster for ADAMTS15: ADAM metallopeptidase with thrombospondin type 1 motif, 15 Hs.681791 [show with all ESTs ] Unigene Representative Sequence: BC109114 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000299164
Expression for ADAMTS15
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ADAMTS15 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS15 1 / 2 / 3
1 probe-set matching ADAMTS15 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.681791 UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 Tissue specificity : Expressed in fetal liver and kidney, but not in any of the adult tissuesexamined
Orthologs for ADAMTS15
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ADAMTS15 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ADAMTS15 ENSEMBL Gene Tree for ADAMTS15 Paralogs for ADAMTS15 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ADAMTS15 gene ADAMTS9 2 ADAMTS20 2
SNPs/Variants for ADAMTS15 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ADAMTS15 (up to first 250kb)
Disorders & Mutations for ADAMTS15
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607509
Medical News for ADAMTS15 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ADAMTS15 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for ADAMTS15 gene : Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212) 2, 3, 4 Cal S....Lopez-Otin C. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618) 3 Porter S....Edwards D.R. (2006) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 4 Sjoeblom T.... Velculescu V.E. (2006) The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. (PubMed id 15599946) 3 Cross N.A....Eaton C.L. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Expression of ADAMs and their inhibitors in sputum from patients with asthma. (PubMed id 17088949) 1 Paulissen G....Cataldo D.D. (2006) ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. (PubMed id 15880812) 1 Demircan K....Ninomiya Y. (2005) ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936) 1 Collins-Racie L.A....LaVallie E.R. (2004)
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Genome Databases showing ADAMTS15
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ADAMTS15
(According to HUGE )
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Specialized Databases showing ADAMTS15 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ADAMTS15 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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