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Aliases for ADAMTS15 Gene

Aliases for ADAMTS15 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15 2 3 5
  • ADAM-TS 15 3 4
  • ADAM-TS15 3 4
  • ADAMTS-15 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 15, Preproprotein 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 15 2
  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 15 3
  • Metalloprotease Disintegrin 15 With Thrombospondin Domains 3
  • EC 3.4.24.82 63
  • EC 3.4.24.14 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS15 Gene

Previous GeneCards Identifiers for ADAMTS15 Gene

  • GC11P132319
  • GC11P131831
  • GC11P130352
  • GC11P129856
  • GC11P129824
  • GC11P126273
  • GC11P130318

Summaries for ADAMTS15 Gene

Entrez Gene Summary for ADAMTS15 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS15 Gene

ADAMTS15 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino) and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS15 Gene

Genomics for ADAMTS15 Gene

Regulatory Elements for ADAMTS15 Gene

Enhancers for ADAMTS15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS15 on UCSC Golden Path with GeneCards custom track

Promoters for ADAMTS15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTS15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS15 Gene

Chromosome:
11
Start:
130,448,974 bp from pter
End:
130,476,645 bp from pter
Size:
27,672 bases
Orientation:
Plus strand

Genomic View for ADAMTS15 Gene

Genes around ADAMTS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS15 Gene

Proteins for ADAMTS15 Gene

  • Protein details for ADAMTS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE58-ATS15_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 15
    Protein Accession:
    Q8TE58
    Secondary Accessions:
    • Q32MI6

    Protein attributes for ADAMTS15 Gene

    Size:
    950 amino acids
    Molecular mass:
    103287 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS15 Gene

Proteomics data for ADAMTS15 Gene at MOPED

Post-translational modifications for ADAMTS15 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 141, Asn 591, Asn 623, and Asn 679
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAMTS15 Gene

Gene Families for ADAMTS15 Gene

Suggested Antigen Peptide Sequences for ADAMTS15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE58

UniProtKB/Swiss-Prot:

ATS15_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 3 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS15: view

Function for ADAMTS15 Gene

Enzyme Numbers (IUBMB) for ADAMTS15 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with ADAMTS15: view

Phenotypes for ADAMTS15 Gene

genes like me logo Genes that share phenotypes with ADAMTS15: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS15 Gene

Localization for ADAMTS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS15 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS15 Gene COMPARTMENTS Subcellular localization image for ADAMTS15 gene
Compartment Confidence
extracellular 4
cytosol 3
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with ADAMTS15: view

Pathways & Interactions for ADAMTS15 Gene

genes like me logo Genes that share pathways with ADAMTS15: view

Pathways by source for ADAMTS15 Gene

Interacting Proteins for ADAMTS15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299164%0d%0a9606.ENSP00000361125%0d%0a
Selected Interacting proteins: ENSP00000299164 for ADAMTS15 Gene via STRING

Symbol External ID(s) Details
VEGFA

Gene Ontology (GO) - Biological Process for ADAMTS15 Gene

None

No data available for SIGNOR curated interactions for ADAMTS15 Gene

Drugs & Compounds for ADAMTS15 Gene

No Compound Related Data Available

Transcripts for ADAMTS15 Gene

mRNA/cDNA for ADAMTS15 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS15 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS15 Gene

No ASD Table

Relevant External Links for ADAMTS15 Gene

GeneLoc Exon Structure for
ADAMTS15
ECgene alternative splicing isoforms for
ADAMTS15

Expression for ADAMTS15 Gene

mRNA expression in normal human tissues for ADAMTS15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for ADAMTS15 Gene

This gene is overexpressed in Heart (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS15 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS15 Gene Hs.534221

mRNA Expression by UniProt/SwissProt for ADAMTS15 Gene

Q8TE58-ATS15_HUMAN
Tissue specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
genes like me logo Genes that share expression patterns with ADAMTS15: view

Protein tissue co-expression partners for ADAMTS15 Gene

- Elite partner

Primer Products

Orthologs for ADAMTS15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS15 35
  • 89.26 (n)
  • 93 (a)
ADAMTS15 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS15 35
  • 86.19 (n)
  • 86.34 (a)
ADAMTS15 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts15 35
  • 87.89 (n)
  • 93.05 (a)
Adamts15 16
Adamts15 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS15 35
  • 99.16 (n)
  • 99.47 (a)
ADAMTS15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts15 35
  • 88.6 (n)
  • 93.16 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS15 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS15 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS15 35
  • 76.17 (n)
  • 77.75 (a)
ADAMTS15 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS15 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts15 35
  • 65.68 (n)
  • 72.02 (a)
Str.13514 35
zebrafish
(Danio rerio)
Actinopterygii adamts15a 36
  • 62 (a)
OneToMany
adamts15b 36
  • 63 (a)
OneToMany
Species with no ortholog for ADAMTS15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS15 Gene

ENSEMBL:
Gene Tree for ADAMTS15 (if available)
TreeFam:
Gene Tree for ADAMTS15 (if available)

Paralogs for ADAMTS15 Gene

(9) SIMAP similar genes for ADAMTS15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS15: view

Variants for ADAMTS15 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036150 A colorectal cancer sample
VAR_036151 A colorectal cancer sample
rs11222114 - 130,471,067(+) AGCCA(A/G)TGGCA reference, missense
rs731446 -- 130,469,417(+) TGCAA(C/G/T)CTGGA reference, synonymous-codon
rs1270640 -- 130,458,972(+) TGTTT(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS15 Gene

Variant ID Type Subtype PubMed ID
dgv446e1 CNV Complex 17122850
nsv508660 CNV Loss 20534489
nsv550 CNV Insertion 18451855
nsv8877 CNV Gain 18304495

Variation tolerance for ADAMTS15 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS15 Gene

HapMap Linkage Disequilibrium report
ADAMTS15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS15 Gene

Disorders for ADAMTS15 Gene

Relevant External Links for ADAMTS15

Genetic Association Database (GAD)
ADAMTS15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS15

No disorders were found for ADAMTS15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS15 Gene

Publications for ADAMTS15 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S. … Lopez-Otin C. (Gene 2002) 2 3 4 67
  2. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. (PMID: 19458070) Viloria C.G. … LA^pez-OtA-n C. (Cancer Res. 2009) 3 23
  3. Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. (PMID: 25099234) Kelwick R. … Edwards D.R. (Int. J. Cancer 2015) 3
  4. Genetic study of intracranial aneurysms. (PMID: 25649796) Yan J. … Koizumi A. (Stroke 2015) 3
  5. Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. (PMID: 23233679) Stupka N. … McCulloch D.R. (J. Biol. Chem. 2013) 3

Products for ADAMTS15 Gene

Sources for ADAMTS15 Gene

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