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ADAMTS15 Gene

protein-coding   GIFtS: 51
GCID: GC11P130318

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 151 2     A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 15, Preproprotein2
ADAM-TS152 3     Metalloprotease Disintegrin 15 With Thrombospondin Domains2
ADAMTS-152 3     EC 3.4.24.-3
ADAM-TS 152 3     EC 3.4.248
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 151
     EC 3.4.24.148
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 152     EC 3.4.24.828

External Ids:    HGNC: 163051   Entrez Gene: 1706892   Ensembl: ENSG000001661067   OMIM: 6075095   UniProtKB: Q8TE583   

Export aliases for ADAMTS15 gene to outside databases

Previous GC identifers: GC11P132319 GC11P131831 GC11P130352 GC11P129856 GC11P129824 GC11P126273


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS15 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. ADAMTS family members share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ADAMTS15 Gene:
ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif, 15) is a protein-coding gene. Diseases associated with ADAMTS15 include chondrosarcoma, and breast and colorectal cancer. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS15 gene promoter:
         ER-alpha   STAT1   STAT1beta   FOXO3   Lmo2   STAT1alpha   FOXO3b   FOXL1   FOXO3a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS15 promoter sequence
   Search Chromatin IP Primers for ADAMTS15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P130318:  view genomic region     (about GC identifiers)

Start:
130,318,869 bp from pter      End:
130,346,539 bp from pter
Size:
27,671 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor  
Size: 950 amino acids; 103287 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q32MI6

Explore the universe of human proteins at neXtProt for ADAMTS15: NX_Q8TE58

Explore proteomics data for ADAMTS15 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn141, Asn591, Asn623, Asn679
  • Selected DME Specific Peptides for ADAMTS15 (Q8TE58) (see all 10)
     SCSVIED  GTMCDPK  VIEDDGL  VETLVVAD 


    See ADAMTS15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620686.1  
    ENSEMBL proteins: 
     ENSP00000299164  
    Reactome Protein details: Q8TE58

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS15
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q8TE58

    ProtoNet protein and cluster: Q8TE58

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains


    ADAMTS15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ADAMTS15 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS15_HUMAN, Q8TE58: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTS15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAMTS15 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch Signaling Pathway (sino)
    Notch Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ADAMTS15
        Notch Signaling Pathway

    1 Reactome Pathway for ADAMTS15
        O-glycosylation of TSR domain-containing proteins



    ADAMTS15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS15
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS15

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    ADAMTS15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTS15 (ATS15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAMTS15 gene: 
    NM_139055.2  

    Unigene Cluster for ADAMTS15:

    ADAM metallopeptidase with thrombospondin type 1 motif, 15
    Hs.534221  [show with all ESTs]
    Unigene Representative Sequence: NM_139055
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000299164(uc010scd.2)
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    Additional mRNA sequence: 

    AJ315733.1 AK123049.1 AK130067.1 BC109114.1 

    4 DOTS entries:

    DT.412703  DT.101975133  DT.97822376  DT.99999236 

    3 AceView cDNA sequences:

    AJ315733 NM_139055 CF994242 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAMTS15 Expression
    About this image


    ADAMTS15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Cartilage (Muscoskeletal System)
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
     
     Heart (Cardiovascular System)
     
     Ovary (Reproductive System)
    ADAMTS15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534221

    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Tissue specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues examined

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS15 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts151 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 87.89(n)1
    93.05(a)1
      9 (16.45 cM)5
    2351301  NM_001024139.11  NP_001019310.11 
     308991555 
    chicken
    (Gallus gallus)
    Aves ADAMTS151 ADAM metallopeptidase with thrombospondin type 1 motif, more 76.17(n)
    77.75(a)
      419733  XM_417874.4  XP_417874.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS156
    ADAM metallopeptidase with thrombospondin type 1 m...
    74(a)
    1 ↔ 1
    GL343197.1(433549-467281)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.135142 Transcribed sequence with weak similarity to protein more 75.22(n)    BX734088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adamts15b6
    adamts15a6
    ADAM metallopeptidase with thrombospondin type 1 m...
    ADAM metallopeptidase with thrombospondin type 1 m...
    63(a)
    62(a)
    1 ↔ many
    1 ↔ many
    15(16622503-16637815) ENSDARG00000033544
    5(31818027-31848085) ENSDARG00000029124


    ENSEMBL Gene Tree for ADAMTS15 (if available)
    TreeFam Gene Tree for ADAMTS15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS15 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  
    ADAMTS52  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    9 SIMAP similar genes for ADAMTS15 using alignment to 1 protein entry:     ATS15_HUMAN:
    TSHZ2    ADAMTS8    ADAMTS1    DKFZp686E01144    ADAMTS4    ADAMTS5
    ADAMTS20    ADAMTS9    ADAMTS6

    ADAMTS15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS15 (see all 777)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361504
    A colorectal cancer sample4--see VAR_0361502 Q R mis40--------
    VAR_0361514
    A colorectal cancer sample4--see VAR_0361512 C G mis40--------
    rs15461091,2
    C,F,A,H--130316869(-) AAAATG/CGGGCC 1 -- us2k120Minor allele frequency- C:0.37NS EA NA WA CSA 1152
    rs1437540501,2
    C--130316885(+) TGTTTC/GCTGGA 1 -- us2k10--------
    rs1463966841,2
    --130316936(+) ATCTCC/TACATC 1 -- us2k10--------
    rs1145297091,2
    C,F--130316968(+) TACAAC/G/TGGCTC 1 -- us2k11WA 118
    rs762420031,2
    C--130317033(+) TTCTAC/TCAGGA 1 -- us2k13Minor allele frequency- T:0.12WA NA 240
    rs1485957791,2
    --130317134(+) ACTCTC/TTTCTG 1 -- us2k10--------
    rs1131324951,2
    C--130317173(+) TCTGGC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs751493661,2
    F--130317298(+) CGGGAG/TGCCGA 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for ADAMTS15 (130318869 - 130346539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAMTS15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv550CNV Insertion18451855
    nsv508660CNV Loss20534489
    nsv8877CNV Gain18304495
    dgv446e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607509    OMIM disorders: --

    8 diseases for ADAMTS15:    
    About MalaCards
    chondrosarcoma    breast and colorectal cancer    asthma    colorectal cancer
    cervicitis    squamous cell carcinoma    prostate cancer    prostatitis


    ADAMTS15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTS15

    Export disorders for ADAMTS15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS15 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ADAMTS15)
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    1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2, 3 Cal S....Lopez-Otin C. (Gene 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. (PubMed id 19458070)1, 9 Viloria C.G....LA^pez-OtA-n C. (Cancer Res. 2009)
    4. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    5. Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. (PubMed id 23233679)1 Stupka N....McCulloch D.R. (J. Biol. Chem. 2013)
    6. Androgen regulates ADAMTS15 gene expression in prostate cancer cells. (PubMed id 20590445)1 Molokwu C.N....Buttle D.J. (Cancer Invest. 2010)
    7. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)1 Porter S....Edwards D.R. (Int. J. Cancer 2006)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    9. The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. (PubMed id 15599946)1 Cross N.A....Eaton C.L. (Prostate 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170689 HGNC: 16305 AceView: ADAMTS15 Ensembl:ENSG00000166106 euGenes: HUgn170689
    ECgene: ADAMTS15 H-InvDB: ADAMTS15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS15 gene:
    Search GeneIP for patents involving ADAMTS15

    GeneCards and IP:
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