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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS15 Gene

protein-coding   GIFtS: 47
GCID: GC11P130318

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 6 diseases affiliated with
ADAMTS15 via our new
 Human Malady Compendium 
Biological research products
for ADAMTS15
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 151 2     A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 15, Preproprotein2
ADAM-TS152 3     Metalloprotease Disintegrin 15 With Thrombospondin Domains2
ADAMTS-152 3     EC 3.4.24.-3
ADAM-TS 152 3     EC 3.4.248
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 151
     EC 3.4.24.148
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 152     EC 3.4.24.828

External Ids:    HGNC: 163051   Entrez Gene: 1706892   Ensembl: ENSG000001661067   OMIM: 6075095   UniProtKB: Q8TE583   

Export aliases for ADAMTS15 gene to outside databases

Previous GC identifers: GC11P132319 GC11P131831 GC11P130352 GC11P129856 GC11P129824 GC11P126273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS15:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. ADAMTS family members share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded
by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. (provided by RefSeq, Jul
2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS15 gene promoter:
         ER-alpha   STAT1   STAT1beta   FOXO3   Lmo2   STAT1alpha   FOXO3b   FOXL1   FOXO3a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS15 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P130318:  view genomic region     (about GC identifiers)

Start:
130,318,869 bp from pter      End:
130,346,539 bp from pter
Size:
27,671 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor  
Size: 950 amino acids; 103287 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q32MI6

Explore the universe of human proteins at neXtProt for ADAMTS15: NX_Q8TE58

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
  • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TE58

  • 4/10 DME Specific Peptides for ADAMTS15 (Q8TE58) (see all 10)
     SCSVIED  GTMCDPK  VIEDDGL  VETLVVAD 

    ADAMTS15 Protein expression data from MOPED and PaxDb:    About this image 
    ADAMTS15 Protein Expression
    REFSEQ proteins: NP_620686.1  
    ENSEMBL proteins: 
     ENSP00000299164  

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    Uscn Proteins for ADAMTS15

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    ADAMTS15 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADAMTS15 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR013277 Pept_M12B_ADAM-TS8

    Graphical View of Domain Structure for InterPro Entry Q8TE58

    ProtoNet protein and cluster: Q8TE58

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ADAMTS15 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS15

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    ADAMTS15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTS15
    Search CenterWatch for drugs/clinical trials and news about ADAMTS15 / ATS15 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS15 gene: 
    NM_139055.2  

    Unigene Cluster for ADAMTS15:

    ADAM metallopeptidase with thrombospondin type 1 motif, 15
    Hs.534221  [show with all ESTs]
    Unigene Representative Sequence: NM_139055
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000299164(uc010scd.2)

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    Additional cDNA sequence: 

    AJ315733.1 AK123049.1 AK130067.1 BC109114.1 

    4 DOTS entries:

    DT.412703  DT.101975133  DT.97822376  DT.99999236 

    3 AceView cDNA sequences:

    NM_139055 AJ315733 CF994242 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    ADAMTS15 Expression
    About this image

    ADAMTS15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See ADAMTS15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS15

    SOURCE GeneReport for Unigene cluster: Hs.534221

    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Tissue specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues examined

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS15 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ADAMTS151 ADAM metallopeptidase with thrombospondin type 1 motif, more 76.21(n)
    77.98(a)
      419733  XM_417874.3  XP_417874.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS156
    --
    73(a)
    1 ↔ 1
    GL343197.1(433549-467281)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.135142 Transcribed sequence with weak similarity to protein more 75.22(n)    BX734088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000020591 A disintegrin and metalloproteinase with thrombospondin more 65.07(n)
    66.78(a)
      100002059  XM_001341899.1  XP_001341935.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG148696
    --
    16(a)
    1 → many
    3R(11267965-11301915)
    worm
    (Caenorhabditis elegans)
    Secernentea gon-16
    mig-176
    ADAM family mig-17
    16(a)
    15(a)
    1 ↔ many
    possible ortholog
    IV(9935046-9945754)
    V(11446634-11449228)


    ENSEMBL Gene Tree for ADAMTS15 (if available)
    TreeFam Gene Tree for ADAMTS15 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS15 gene
    ADAMTS172  ADAMTS182  ADAMTS62  ADAMTS122  ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS92  
    ADAMTS162  ADAMTS102  ADAMTS72  ADAMTS12  ADAMTS192  ADAMTS142  ADAMTS22  ADAMTS82  
    ADAMTS32  
    12 SIMAP similar genes for ADAMTS15 using alignment to 1 protein entry:     ATS15_HUMAN:
    TSHZ2    ADAMTS8    ADAMTS1    DKFZp686E01144    ADAMTS4    ADAMTS5
    ADAMTS20    ADAMTS9    ADAMTS6    ADAMTS12    ADAMTS14    ADAMTS2

    ADAMTS15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/607 NCBI SNPs in ADAMTS15 are shown (see all 607    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15461091,2
    C,F,A,H--130316869(-) AAAATG/CGGGCC 1 -- us2k120Minor allele frequency- C:0.37NS EA NA WA CSA 1152
    rs1437540501,2
    --130316885(+) TGTTTC/GCTGGA 1 -- us2k10--------
    rs1463966841,2
    --130316936(+) ATCTCC/TACATC 1 -- us2k10--------
    rs1145297091,2
    F--130316968(+) TACAAG/CGGCTC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs762420031,2
    C--130317033(+) TTCTAC/TCAGGA 1 -- us2k13Minor allele frequency- T:0.12WA NA 240
    rs1485957791,2
    --130317134(+) ACTCTC/TTTCTG 1 -- us2k10--------
    rs751493661,2
    F--130317298(+) CGGGAG/TGCCGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs49375181,2
    C,A,H--130317364(+) AACCCC/AGTCTC 1 -- us2k14Minor allele frequency- A:0.29NA EA 244
    rs619139121,2
    C--130317460(+) GTGGTC/TGCAGT 1 -- us2k13Minor allele frequency- T:0.08NA WA 240
    rs730448501,2
    C--130317490(+) GGAGGT/CAGGAA 1 -- us2k12Minor allele frequency- C:0.07NA 122

    HapMap Linkage Disequilibrium report for ADAMTS15 (130318869 - 130346539 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAMTS15
         2 CNVs: 3869 30569

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADAMTS15 for disorders           About GeneDecksing

    OMIM gene information: 607509    OMIM disorders: --

    6 diseases for ADAMTS15:    About MalaCards
    chondrosarcoma    breast carcinoma    colorectal cancer    asthma
    carcinoma    prostatitis


    Export disorders for ADAMTS15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS15 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ADAMTS15)
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    1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2, 3 Cal S....Lopez-Otin C. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genetic inactivation of ADAMTS15 metalloprotease in h uman colorectal cancer. (PubMed id 19458070)1, 9 Viloria C.G....LA^pez-OtA-n C. (2009)
    4. Androgen regulates ADAMTS15 gene expression in prosta te cancer cells. (PubMed id 20590445)1 Molokwu C.N....Buttle D.J. (2010)
    5. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)1 Porter S....Edwards D.R. (2006)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. (PubMed id 15599946)1 Cross N.A....Eaton C.L. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Expression profiles and clinical correlations of degr adome components in the tumor microenvironment of head and neck squamous cell c arcinoma. (PubMed id 20305301)9 Stokes A....KAohAori V.M. (2010)
    10. Expression of ADAMs and their inhibitors in sputum from patients with asthma. (PubMed id 17088949)9 Paulissen G....Cataldo D.D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170689 HGNC: 16305 AceView: ADAMTS15 Ensembl:ENSG00000166106 euGenes: HUgn170689
    ECgene: ADAMTS15 H-InvDB: ADAMTS15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS15 gene:
    Search GeneIP for patents involving ADAMTS15

    GeneCards and IP:
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