V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

ADAMTS15 Gene

protein-coding   GIFtS: 47

GC11P129824
ADAM metallopeptidase with thrombospondin type 1 motif, 15
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ADAM-TS15 3
ADAMTS-15 3
EC 3.4.24.- 3
MGC126403 2
Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 15 2
ADAM-TS 15 3
a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 1, 2
a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15, preproprotein 2
metalloprotease disintegrin 15 with thrombospondin domains 2
External Ids
HGNC: 163051
Entrez Gene: 1706892
UniProtKB: Q8TE583
Ensembl: ENSG000001661067
Search outside databases for aliases for ADAMTS15 gene

Previous GC identifers: GC11P132319 GC11P131831 GC11P130352 GC11P129856

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAMTS15:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin
motifs) protein family. ADAMTS family members share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin
type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,
and some have unique C-terminal domains. The protein encoded by this gene has a high sequence
similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADAMTS15 gene  

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P129824:     (about GC identifiers)

Start:
129,824,079 bp from pter
End:
129,848,926 bp from pter
Size:
24,848 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor  
Size: 950 amino acids; 103287 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q32MI6

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1


  • REFSEQ proteins: NP_620686.1  

    ENSEMBL proteins: 
    ENSP00000299164 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ADAMTS15
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADAMTS15)
    Human Recombinant Proteins from Abnova (ADAMTS15)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    About this table

    Antibodies for ADAMTS15: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ADAMTS15), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ADAMTS15)
    Novus Biologicals Antibodies for ADAMTS15

    Assays for ADAMTS15: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/9 InterPro domains/families (see all 9 ):
     IPR000884 Thrombospondin_1_rpt
     IPR018358 Disintegrin_CS
     IPR001818 Pept_M10A_M12B
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B


       GeneDecks  ADAMTS15 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8TE58

    ProtoNet protein and cluster: Q8TE58

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the
    extracellular matrix (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,
    thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the
    activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAMTS15)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS15)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139055

                  Applied Biosystems Silencer® siRNAs for ADAMTS15

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS15  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS15  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_139055
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_139055
                                     untagged cDNA clone in CMV expression vector: NM_139055 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_139055

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0008233 peptidase activity IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADAMTS15
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADAMTS15

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAMTS15)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS15)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139055

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS15  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS15  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_139055  

    REFSEQ mRNAs for ADAMTS15 gene: 

    NM_139055.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_139055  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_139055
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_139055
                                     untagged cDNA clone in CMV expression vector: NM_139055 

    Additional cDNA sequence: 

    AJ315733.1 AK123049.1 BC109114.1 

    2 DOTS entries:

    DT.101975133  DT.97822376 

    3 AceView cDNA sequences:

    NM_139055 AJ315733 CF994242 

    highest scoring ESTs for ADAMTS15:

    AJ315733 CN285485 NM_139055 BC109114 CN348315 CN348316 AA249879 AA298709 AA463893 AA740671 

    Unigene Cluster for ADAMTS15:

    ADAM metallopeptidase with thrombospondin type 1 motif, 15
    Hs.681791  [show with all ESTs]
    Unigene Representative Sequence: BC109114


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000299164  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADAMTS15 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS15

    1 / 2 / 3

    1 probe-set matching ADAMTS15 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1553427_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.681791

    UniProtKB/Swiss-Prot: ATS15_HUMAN, Q8TE58
    Tissue specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues
    examined

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ADAMTS15 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ADAMTS151   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 82.04(n)
    82(a)
    489275  XM_546393.2  XP_546393.2 
    chimpanzee
    (Pan troglodytes)
    ADAMTS151   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 99.16(n)
    99.47(a)
    466853  XM_522253.2  XP_522253.2 
    cow
    (Bos taurus)
    ADAMTS151   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 89.21(n)
    92.76(a)
    514927  XM_592846.3  XP_592846.2 
    rat
    (Rattus norvegicus)
    Adamts151   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 88.6(n)
    93.16(a)
    300474  XM_235976.3  XP_235976.3 
    mouse
    (Mus musculus)
    Adamts151, 5 95
    a disintegrin-like and metallopeptidase (reprolysin more1, 5 87.89(n)1
    93.05(a)1
    2351301  NM_001024139.11  NP_001019310.11 
     AA1711465  AI4662785  (see all 9)
    About this table        Species with no ortholog for ADAMTS15

    ENSEMBL Gene Tree for ADAMTS15
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADAMTS15 gene
    ADAMTS92  ADAMTS202  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/172 NCBI SNPs in ADAMTS15 are shown (see all 172 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 73)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs15461091,2
    A,C,F,H129822079(-) AAAATG/CGGGCC 1 -- ng518Minor allele frequency- C:0.37EU EA WA NA 774
    --
    rs49375181,2
    A,C129822574(+) aacccA/Cgtctc 1 -- ng510--------
    rs112221141,2
    C,F129846172(+) AGCCAG/ATGGCA 1 S/N mis1 ese34Minor allele frequency- A:0.50EU EA WA 412
    --
    rs49375191,2
    C129822726(+) tcaccC/Tgaggt 1 -- ng51 tfbs30--------
    rs7314461,2
    A,C,F,H129844522(+) TGCAAC/TCTGGA 1 N/N syn111Minor allele frequency- T:0.29NA EA EU WA 994
    rs108942031,2
    A,C,F,H129833092(+) CTCTCG/ATTTGA 1 -- int18Minor allele frequency- A:0.50EU EA WA 832
    rs71126981,2
    A,C,F,H129835261(+) agcctA/Gttgtg 1 -- int14Minor allele frequency- G:0.38EU EA WA 420
    rs112221091,2
    A,C,F,H129841446(+) gacctA/Gcagac 1 -- int18Minor allele frequency- G:0.49EU EA WA 838
    rs108942021,2
    A,C,F,H129830853(+) AGACAG/AGGTGC 1 -- int18Minor allele frequency- A:0.49EU EA WA 836
    rs112221111,2
    A,C,F,H129843373(+) AGCACC/TGGAAA 1 -- int112Minor allele frequency- T:0.24EU EA WA 1248
    About this table

    HapMap Linkage Disequilibrium images for ADAMTS15 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 607509

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for ADAMTS15 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 170689 HGNC: 16305 AceView: ADAMTS15 Ensembl:ENSG00000166106 euGenes: HUgn170689
    ECgene: ADAMTS15 H-InvDB: ADAMTS15
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADAMTS15:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ADAMTS15-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ADAMTS15 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ADAMTS15 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (ADAMTS15)
     Antibodies (ADAMTS15)
     Chimera RNAi (ADAMTS15)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ADAMTS15)
     Antibodies (ADAMTS15)
     Search OriGene for ADAMTS15
     Search Tocris compounds for ADAMTS15




     Drugs for ADAMTS15
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ADAMTS15

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    ADAMTS15 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com