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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS14 Gene

protein-coding   GIFtS: 53
GCID: GC10P072432

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 4 diseases affiliated with
ADAMTS14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS14    

Aliases
for ADAMTS14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 141 2     Metalloprotease-Disintegrin Protease2
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 141 2
     EC 3.4.24.-3
ADAM-TS142 3     EC 3.4.248
ADAMTS-142 3     EC 3.4.24.148
ADAM-TS 142 3     EC 3.4.24.828
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 142     

External Ids:    HGNC: 148991   Entrez Gene: 1407662   Ensembl: ENSG000001383167   OMIM: 6075065   UniProtKB: Q8WXS83   

Export aliases for ADAMTS14 gene to outside databases

Previous GC identifers: GC10P071167 GC10P071519 GC10P072324 GC10P071777 GC10P072102 GC10P066426


Summaries
for ADAMTS14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS14:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly
similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares
the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript
variants of this gene have been identified. They result from the use of two different promoters and transcription
initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been
defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
Function: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized
as a latent enzyme that requires activation to display aminoprocollagen peptidase activity




Genomic Views
for ADAMTS14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS14 gene promoter:
         STAT1   AML1a   FOXF2   Bach2   FOXD1   AP-2gamma   CREB   HEN1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS14 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

ADAMTS14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS14 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072432:  view genomic region     (about GC identifiers)

Start:
 72,432,559 bp from pter      End:
 72,522,197 bp from pter
Size:
 89,639 bases      Orientation:
 plus strand

Proteins
for ADAMTS14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor  
Size: 1223 amino acids; 133888 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q5T4G0 Q5T4G1 Q8TE55 Q8TEY8
Alternative promoter usage, Alternative splicing: 4 isoforms:  Q8WXS8-1   Q8WXS8-2   Q8WXS8-3   Q8WXS8-4   (Produced by alternative splicing of isoform A)

Explore the universe of human proteins at neXtProt for ADAMTS14: NX_Q8WXS8

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXS8

    • 4/16 DME Specific Peptides for ADAMTS14 (Q8WXS8) (see all 16)
     VCGGDNS  TKYGCRR  SNCDGLAG  EQCRFDFG 

    ADAMTS14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_542453.2  NP_631894.2  

    ENSEMBL proteins: 
     ENSP00000362304   ENSP00000362303  
    Reactome Protein details: Q8WXS8
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    Uscn Proteins for ADAMTS14

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--


    ADAMTS14 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAMTS14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS14 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q8WXS8

    ProtoNet protein and cluster: Q8WXS8

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 4 TSP type-1 domains


    Function
    for ADAMTS14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
    Function: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized
    as a latent enzyme that requires activation to display aminoprocollagen peptidase activity

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

    miRNA
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    hsa-miR-30c hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g hsa-miR-124
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--


    ADAMTS14 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ADAMTS14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Collagen biosynthesis and modifying enzymes0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ADAMTS14
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    ADAMTS14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ADAMTS14 (ENSP000003623044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1ENSP000003057144STRING: ENSP00000305714
    TLL1ENSP000000612404STRING: ENSP00000061240
    PCOLCEENSP000002230614STRING: ENSP00000223061
    PCOLCE2ENSP000002959924STRING: ENSP00000295992
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--
    GO:0030574collagen catabolic process IEA--


    ADAMTS14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS14
    Search CenterWatch for drugs/clinical trials and news about ADAMTS14 / ATS14 

    Transcripts
    for ADAMTS14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS14 gene (2 alternative transcripts): 
    NM_080722.3  NM_139155.2  

    Unigene Cluster for ADAMTS14:

    ADAM metallopeptidase with thrombospondin type 1 motif, 14
    Hs.352156  [show with all ESTs]
    Unigene Representative Sequence: NM_139155
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373208(uc001jrg.3) ENST00000373207(uc001jrh.3 uc001jri.1)


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    hsa-miR-30c hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g hsa-miR-124
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF358666.1 AF366351.1 AJ345098.1 AK128469.1 

    2 DOTS entries:

    DT.92040591  DT.101955372 

    10 AceView cDNA sequences:

    NM_139155 BX382380 NM_080722 AF366351 AF358666 AJ345098 AJ403134 AK128469 
    AW172882 BF823025 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
    SP1:              -                             -                       -                                               -     -                                 
    SP2:              -                                                     -                                               -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -                           

    ExUns: 22 ^ 23 ^ 24a · 24b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ADAMTS14

    Expression
    for ADAMTS14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTAGTGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ADAMTS14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS14

    SOURCE GeneReport for Unigene cluster: Hs.352156

    UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
    Tissue specificity: Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues

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    In Situ
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    Orthologs
    for ADAMTS14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS14 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS141 ADAM metallopeptidase with thrombospondin type 1 motif, more 72.24(n)
    69.94(a)    		   423712  XM_003641474.1  XP_003641522.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAMTS146
    --
    		 --
    		 71(a)
    21(a)
    		 1 ↔ 1
    possible ortholog
    		 3(50500971-50604209)
    2(10454625-10471737)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01072659.16
    		 --
    		 67(a)
    		 1 ↔ 1
    		 12(49222792-49275286)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 23(a)
    		 1 → many
    		 Group16.4(41440-51250)


    ENSEMBL Gene Tree for ADAMTS14 (if available)
    TreeFam Gene Tree for ADAMTS14 (if available) 

    Paralogs
    for ADAMTS14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS14 gene
    ADAMTS172  ADAMTS72  ADAMTS12  ADAMTS182  ADAMTS62  ADAMTS192  ADAMTS122  ADAMTS22  
    ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS152  ADAMTS162  ADAMTS82  ADAMTS92  ADAMTS32  
    ADAMTS102  
    5 SIMAP similar genes for ADAMTS14 using alignment to 1 protein entry:     ATS14_HUMAN:
    ADAMTS3    ADAMTS2    ADAMTS15    ADAMTS18    ADAMTS4

    ADAMTS14 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1943 NCBI SNPs in ADAMTS14 are shown (see all 1943)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1410326591,2
    		--72430565(+) TTTTCC/TAGGGG 2 -- us2k10--------
    rs1465936891,2
    		C,--72430636(+) TTCTG-/TCCC  
     GCAGGGT    TCCCA     		2 -- us2k10--------
    rs1394919141,2
    		--72430774(+) AGCCT-/TCTCTCT 2 -- us2k10--------
    rs105403331,2
    		C,--72430821(+) tctct-/TTCctatc 2 -- us2k10--------
    rs16416801,2
    		C--72430864(-) gtgtgA/Tgagag 2 -- us2k10--------
    rs94150171,2
    		C,H--72430866(+) CTCTCT/ACACAC 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1479432321,2
    		--72430946(+) AATCCC/TGTCTG 2 -- us2k10--------
    rs732761421,2
    		C,--72430947(+) ATCCTG/ATCTGG 2 -- us2k13Minor allele frequency- A:0.32WA 122
    rs1145513511,2
    		F,--72431009(+) TGTCAC/TCCAGG 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1896229031,2
    		--72431120(+) AGGCGC/TGAGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAMTS14 (72432559 - 72522197 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for ADAMTS14
         6 CNVs: 48621 6879 65720 48623 58466 58465
         3 Indels: 48622 71036 48624

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    Disorders / Diseases
    for ADAMTS14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS14 for disorders           About GeneDecksing

    OMIM gene information: 607506    OMIM disorders: --

    4 diseases for ADAMTS14:    About MalaCards
    ehlers-danlos syndrome    multiple sclerosis    alzheimer's disease    osteoarthritis

    Genetic Association Database (GAD): ADAMTS14
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS14 (5 documents)

    Export disorders for ADAMTS14 gene to outside databases

    Publications
    for ADAMTS14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS14 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ADAMTS14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family. (PubMed id 11779638)1, 2, 3, 9 Bolz H.... Kubisch C. (2001)
    2. Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis. (PubMed id 15913795)1, 4, 9 Goertsches R....Montalban X. (2005)
    3. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. (PubMed id 11741898)1, 2 Colige A.... Nusgens B.V. (2002)
    4. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2 Cal S....Lopez-Otin C. (2002)
    5. Expression of ADAMTS-2, -3, -13, and -14 in culprit co ronary lesions in patients with acute myocardial infarction or stable angina. (PubMed id 22205175)1 Lee C.W....Park S.J. (2012)
    6. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)1 Jiang Y. and Zhang H. (2011)
    7. Linkage and genome-wide association analysis of obesi ty-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)1 Johansson A....Gyllensten U. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Analysis of multiple candidate genes in association w ith phenotypes of multiple sclerosis. (PubMed id 20378664)1 Sombekke M.H....Uitdehaag B.M. (2010)
    10. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. (PubMed id 18790654)1 Rodriguez-Lopez J....Gonzalez A. (2009)

    External Searches for ADAMTS14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ADAMTS14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140766 HGNC: 14899 AceView: ADAMTS14 Ensembl:ENSG00000138316 euGenes: HUgn140766
    ECgene: ADAMTS14 H-InvDB: ADAMTS14

    Other Databases showing ADAMTS14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMTS14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAMTS14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS14 gene:
    Search GeneIP for patents involving ADAMTS14

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