Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS14 Gene

protein-coding   GIFtS: 55
GCID: GC10P072432

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 141 2     Metalloprotease-Disintegrin Protease2
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 141 2
     EC 3.4.24.-3
ADAM-TS142 3     EC 3.4.248
ADAMTS-142 3     EC 3.4.24.148
ADAM-TS 142 3     EC 3.4.24.828
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 142     

External Ids:    HGNC: 148991   Entrez Gene: 1407662   Ensembl: ENSG000001383167   OMIM: 6075065   UniProtKB: Q8WXS83   

Export aliases for ADAMTS14 gene to outside databases

Previous GC identifers: GC10P071167 GC10P071519 GC10P072324 GC10P071777 GC10P072102 GC10P066426


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS14 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene
is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded
protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3.
Various transcript variants of this gene have been identified. They result from the use of two different
promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of
some transcripts has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS14 Gene: 
ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif, 14) is a protein-coding gene. Diseases associated with ADAMTS14 include ehlers-danlos syndrome, and acute myocardial infarction, and among its related super-pathways are Collagen formation. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
Function: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be
synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS14 gene promoter:
         STAT1   AML1a   FOXF2   Bach2   FOXD1   AP-2gamma   CREB   HEN1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS14 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

ADAMTS14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS14 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072432:  view genomic region     (about GC identifiers)

Start:
72,432,559 bp from pter      End:
72,522,197 bp from pter
Size:
89,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor  
Size: 1223 amino acids; 133888 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q5T4G0 Q5T4G1 Q8TE55 Q8TEY8
Alternative promoter usage, Alternative splicing: 4 isoforms:  Q8WXS8-1   Q8WXS8-2   Q8WXS8-3   Q8WXS8-4   (Produced by alternative splicing of isoform A)

Explore the universe of human proteins at neXtProt for ADAMTS14: NX_Q8WXS8

Explore proteomics data for ADAMTS14 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WXS8

  • 4/16 DME Specific Peptides for ADAMTS14 (Q8WXS8) (see all 16)
     VCGGDNS  TKYGCRR  SNCDGLAG  EQCRFDFG 

    ADAMTS14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS14 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_542453.2  NP_631894.2  

    ENSEMBL proteins: 
     ENSP00000362304   ENSP00000362303  
    Reactome Protein details: Q8WXS8
    Human Recombinant Protein Products for ADAMTS14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAMTS14
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADAMTS14
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS14
    Novus Biologicals ADAMTS14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMTS14 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTS14 for ontologies           About GeneDecksing



    ADAMTS14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADAMTS14
    GenScript Custom Superior Antibodies Services for ADAMTS14
    Novus Biologicals ADAMTS14 Antibody
    Abcam antibodies for ADAMTS14
    Cloud-Clone Corp. Antibodies for ADAMTS14 
    Search ThermoFisher Antibodies for ADAMTS14
    LSBio Antibodies in human, mouse, rat for ADAMTS14 

    Assay Products for ADAMTS14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAMTS14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTS14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAMTS14 
    Cloud-Clone Corp. CLIAs for ADAMTS14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS14 
    ADAMTS family

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q8WXS8

    ProtoNet protein and cluster: Q8WXS8

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 4 TSP type-1 domains


    ADAMTS14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS14_HUMAN, Q8WXS8
    Function: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be
    synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    ADAMTS14 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAMTS14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS14
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS14 (see all 25):
    hsa-miR-30c hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAMTS14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAMTS14
    Sirion Biotech Customized adenovirus for overexpression of ADAMTS14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADAMTS14 (see all 9)
    OriGene ORF clones in mouse, rat for ADAMTS14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAMTS14 (NM_139155)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS14
    Sirion Biotech Customized lentivirus for stable overexpression of ADAMTS14 
                         Customized lentivirus expression plasmids for stable overexpression of ADAMTS14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAMTS14
    Search LifeMap BioReagents cell lines for ADAMTS14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAMTS14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Extracellular matrix organization0.39
    Collagen formation0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ADAMTS14
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    ADAMTS14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ADAMTS14 (ENSP000003623044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1ENSP000003057144STRING: ENSP00000305714
    TLL1ENSP000000612404STRING: ENSP00000061240
    PCOLCEENSP000002230614STRING: ENSP00000223061
    PCOLCE2ENSP000002959924STRING: ENSP00000295992
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--
    GO:0030574collagen catabolic process IEA--

    ADAMTS14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS14 (ATS14)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS14 / ATS14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS14 gene (2 alternative transcripts): 
    NM_080722.3  NM_139155.2  

    Unigene Cluster for ADAMTS14:

    ADAM metallopeptidase with thrombospondin type 1 motif, 14
    Hs.352156  [show with all ESTs]
    Unigene Representative Sequence: NM_139155
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373208(uc001jrg.3) ENST00000373207(uc001jrh.3 uc001jri.1)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS14
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS14 (see all 25):
    hsa-miR-30c hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAMTS14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS14
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS14 (see all 9)
    OriGene ORF clones in mouse, rat for ADAMTS14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAMTS14 (NM_139155)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS14
    Sirion Biotech Customized lentivirus for stable overexpression of ADAMTS14 
                         Customized lentivirus expression plasmids for stable overexpression of ADAMTS14 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS14

    Additional mRNA sequence: 

    AF358666.1 AF366351.1 AJ345098.1 AK128469.1 

    2 DOTS entries:

    DT.92040591  DT.101955372 

    10 AceView cDNA sequences:

    AF366351 NM_080722 NM_139155 BX382380 AJ403134 AK128469 AJ345098 AF358666 
    AW172882 BF823025 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
    SP1:              -                             -                       -                                               -     -                                 
    SP2:              -                                                     -                                               -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -                           

    ExUns: 22 ^ 23 ^ 24a · 24b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ADAMTS14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAGTGGGC
    ADAMTS14 Expression
    About this image


    See ADAMTS14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS14

    SOURCE GeneReport for Unigene cluster: Hs.352156

    UniProtKB/Swiss-Prot: ATS14_HUMAN, Q8WXS8
    Tissue specificity: Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal
    tissues

        SABiosciences Custom PCR Arrays for ADAMTS14
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS14 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts141 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 82.42(n)1
    82.97(a)1
      10 (32.16 cM)5
    2373601  NM_001081127.11  NP_001074596.11 
     611971125 
    chicken
    (Gallus gallus)
    Aves ADAMTS141 ADAM metallopeptidase with thrombospondin type 1 motif, more 72.24(n)
    69.94(a)
      423712  XM_003641474.1  XP_003641522.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS146
    Uncharacterized protein
    71(a)
    1 ↔ 1
    3(50500473-50604209)
    zebrafish
    (Danio rerio)
    Actinopterygii ADAMTS146
    ADAM metallopeptidase with thrombospondin type 1 m...
    67(a)
    1 ↔ 1
    12(49222792-49275286)


    ENSEMBL Gene Tree for ADAMTS14 (if available)
    TreeFam Gene Tree for ADAMTS14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS14 gene
    ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS22  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    2 SIMAP similar genes for ADAMTS14 using alignment to 1 protein entry:     ATS14_HUMAN:
    ADAMTS3    ADAMTS2

    ADAMTS14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2337 SNPs in ADAMTS14 are shown (see all 2337)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673950451,2
    C--66426509(+) TGTGT-/CTGTGTG 2 -- int11Minor allele frequency- CT:0.00NA 2
    rs1410326591,2
    --72430565(+) TTTTCC/TAGGGG 2 -- us2k10--------
    rs1465936891,2
    C--72430636(+) TTCTG-/TCCC  
     GCAGGGT
    TCCCA
    2 -- us2k10--------
    rs1394919141,2
    C--72430774(+) AGCCT-/TCTCTCT 2 -- us2k10--------
    rs105403331,2
    C--72430821(+) tctct-/TTCctatc 2 -- us2k10--------
    rs16416801,2
    C--72430864(-) gtgtgA/Tgagag 2 -- us2k10--------
    rs94150171,2
    C,H--72430866(+) CTCTCT/ACACAC 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1479432321,2
    --72430946(+) AATCCC/TGTCTG 2 -- us2k10--------
    rs732761421,2
    C--72430947(+) ATCCTG/ATCTGG 2 -- us2k13Minor allele frequency- A:0.32WA 122
    rs1145513511,2
    F--72431009(+) TGTCAC/TCCAGG 2 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ADAMTS14 (72432559 - 72522197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for ADAMTS14 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821367CNV Deletion20802225
    esv2738206CNV Deletion23290073
    dgv153e199CNV Deletion23128226
    nsv467369CNV Loss19166990
    nsv895709CNV Loss21882294
    nsv895704CNV Loss21882294
    dgv162n67CNV Loss20364138
    nsv895710CNV Loss21882294
    nsv467368CNV Loss19166990
    dgv769n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS14
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607506    OMIM disorders: --

    7 diseases for ADAMTS14:    About MalaCards
    ehlers-danlos syndrome    acute myocardial infarction    osteoarthritis    bipolar disorder
    multiple sclerosis    myocardial infarction    alzheimer's disease


    ADAMTS14 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ADAMTS14
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS14 (5 documents)

    Export disorders for ADAMTS14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS14 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ADAMTS14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family. (PubMed id 11779638)1, 2, 3, 9 Bolz H.... Kubisch C. (2001)
    2. Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis. (PubMed id 15913795)1, 4, 9 Goertsches R....Montalban X. (2005)
    3. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (2011)
    4. Linkage and genome-wide association analysis of obesi ty-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)1, 4 Johansson A....Gyllensten U. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Analysis of multiple candidate genes in association w ith phenotypes of multiple sclerosis. (PubMed id 20378664)1, 4 Sombekke M.H....Uitdehaag B.M. (2010)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    8. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. (PubMed id 11741898)1, 2 Colige A.... Nusgens B.V. (2002)
    9. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PubMed id 11867212)1, 2 Cal S....Lopez-Otin C. (2002)
    10. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)4 Mead S....Collinge J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140766 HGNC: 14899 AceView: ADAMTS14 Ensembl:ENSG00000138316 euGenes: HUgn140766
    ECgene: ADAMTS14 H-InvDB: ADAMTS14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS14 gene:
    Search GeneIP for patents involving ADAMTS14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADAMTS14  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ADAMTS14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAMTS14  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAMTS14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS14   OriGene Custom Protein Services for ADAMTS14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS14
     QIAGEN SeqTarget long-range PCR primers for resequencing ADAMTS14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS14
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS14 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS14
     GenScript Custom Assay Services for ADAMTS14 GenScript Custom Superior Antibodies Services for ADAMTS14
     GenScript Custom overexpressing Cell Line Services for ADAMTS14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAMTS14 promoter
     Search Chromatin IP Primers for ADAMTS14
     RT2 qPCR Primer Assay in human, mouse, rat ADAMTS14
     Search GNC Networks for ADAMTS14
     SABiosciences Custom PCR Arrays for ADAMTS14
     Search Tocris compounds for ADAMTS14 (ATS14)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAMTS14 antibodies
     ADAMTS14 lysates
     Antibodies for ADAMTS14
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADAMTS14
     Antibodies for ADAMTS14
     ELISAs for ADAMTS14
     CLIAs for ADAMTS14
     Search LifeMap BioReagents cell lines for ADAMTS14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS14
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS14
     SwitchGear Promoter luciferase reporter plasmids for ADAMTS14
     Search ThermoFisher Antibodies for ADAMTS14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAMTS14
    Customized:
     lentivirus for stable overexpression of ADAMTS14
     lentivirus expression plasmids for stable overexpression of ADAMTS14
     adenovirus for overexpression of ADAMTS14
     LSBio Antibodies in human, mouse, rat for ADAMTS14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAMTS14 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4