Aliases for ADAMTS14 Gene
External Ids for ADAMTS14 Gene
Previous GeneCards Identifiers for ADAMTS14 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS14 Gene
ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14) is a Protein Coding gene. Among its related pathways are Collagen biosynthesis and modifying enzymes and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.
UniProtKB/Swiss-Prot for ADAMTS14 Gene
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.