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Aliases for ADAMTS14 Gene

Aliases for ADAMTS14 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 14 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 14 2 3
  • ADAM-TS 14 3 4
  • ADAM-TS14 3 4
  • ADAMTS-14 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 14 3
  • Metalloprotease-Disintegrin Protease 3
  • EC 63
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ADAMTS14 Gene

Previous GeneCards Identifiers for ADAMTS14 Gene

  • GC10P071167
  • GC10P071519
  • GC10P072324
  • GC10P071777
  • GC10P072102
  • GC10P072432
  • GC10P066426

Summaries for ADAMTS14 Gene

Entrez Gene Summary for ADAMTS14 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS14 Gene

ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 14) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS14 Gene

  • Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS14 Gene

Genomics for ADAMTS14 Gene

Regulatory Elements for ADAMTS14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS14 Gene

70,672,803 bp from pter
70,762,441 bp from pter
89,639 bases
Plus strand

Genomic View for ADAMTS14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS14 Gene

Proteins for ADAMTS14 Gene

  • Protein details for ADAMTS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 14
    Protein Accession:
    Secondary Accessions:
    • Q5T4G0
    • Q5T4G1
    • Q8TE55
    • Q8TEY8

    Protein attributes for ADAMTS14 Gene

    1223 amino acids
    Molecular mass:
    133888 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS14 Gene


neXtProt entry for ADAMTS14 Gene

Proteomics data for ADAMTS14 Gene at MOPED

Post-translational modifications for ADAMTS14 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn109, Asn475, Asn941, Asn1027, and Ser1220
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADAMTS14 Gene

Gene Families for ADAMTS14 Gene

  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif

Graphical View of Domain Structure for InterPro Entry



  • Q8WXS8
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 4 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS14: view

Function for ADAMTS14 Gene

Molecular function for ADAMTS14 Gene

UniProtKB/Swiss-Prot Function:
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity

Enzyme Numbers (IUBMB) for ADAMTS14 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS14: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS14

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS14 Gene

Localization for ADAMTS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS14 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTS14 Gene COMPARTMENTS Subcellular localization image for ADAMTS14 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTS14: view

Pathways for ADAMTS14 Gene

genes like me logo Genes that share pathways with ADAMTS14: view

Pathways by source for ADAMTS14 Gene

Interacting Proteins for ADAMTS14 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362304 for ADAMTS14 Gene via STRING

Gene Ontology (GO) - Biological Process for ADAMTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0030199 collagen fibril organization IEA --
GO:0030574 collagen catabolic process IEA --
genes like me logo Genes that share ontologies with ADAMTS14: view

Transcripts for ADAMTS14 Gene

mRNA/cDNA for ADAMTS14 Gene

(4) Additional mRNA sequences :
(12) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS14 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1: - - - - -
SP2: - - - -
SP5: -

ExUns: 22 ^ 23 ^ 24a · 24b

Relevant External Links for ADAMTS14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS14 Gene

mRNA expression in normal human tissues for ADAMTS14 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS14 Gene

This gene is overexpressed in Nerve - Tibial (4.1).

Protein differential expression in normal tissues for ADAMTS14 Gene

This gene is overexpressed in Heart (57.1) and Amniocyte (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAMTS14 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS14 Gene Hs.352156

mRNA Expression by UniProt/SwissProt for ADAMTS14 Gene

Tissue specificity: Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues
genes like me logo Genes that share expressions with ADAMTS14: view

Expression partners for ADAMTS14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAMTS14 Gene

Orthologs for ADAMTS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS14 35
  • 87.27 (n)
  • 85.84 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ADAMTS14 35
  • 87.36 (n)
  • 87.6 (a)
  • 87 (a)
(Mus musculus)
Mammalia Adamts14 35
  • 82.25 (n)
  • 82.72 (a)
Adamts14 16
Adamts14 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADAMTS14 35
  • 99.26 (n)
  • 99.02 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Adamts14 35
  • 80.72 (n)
  • 80.66 (a)
(Monodelphis domestica)
Mammalia ADAMTS14 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS14 36
  • 81 (a)
(Gallus gallus)
Aves ADAMTS14 35
  • 73.2 (n)
  • 71.07 (a)
SGPL1 36
  • 68 (a)
(Anolis carolinensis)
Reptilia ADAMTS14 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts14 35
  • 66.79 (n)
  • 69.64 (a)
(Danio rerio)
Actinopterygii ADAMTS14 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea C37C3.6a 37
  • 31 (a)
C37C3.6b 37
  • 31 (a)
T19D2.1 37
  • 27 (a)
Species with no ortholog for ADAMTS14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS14 Gene

Gene Tree for ADAMTS14 (if available)
Gene Tree for ADAMTS14 (if available)

Paralogs for ADAMTS14 Gene

Selected SIMAP similar genes for ADAMTS14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS14: view

Variants for ADAMTS14 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11572 -- 70,762,332(+) ACACG(C/T)GGAGT utr-variant-3-prime
rs614201 -- 70,674,438(-) GGGCC(C/T)CTTAG intron-variant
rs736189 -- 70,715,720(-) CCAAT(A/G)GAAAG intron-variant
rs748164 -- 70,701,043(-) CTTCA(A/T)AAACA intron-variant
rs748165 -- 70,700,899(-) TCAAC(A/G)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS14 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831909 CNV Loss 17160897
dgv769n71 CNV Loss 21882294
dgv160n67 CNV Gain 20364138
nsv825452 CNV Gain 20364138
esv24062 CNV Loss 19812545
nsv819639 CNV Gain 19587683
dgv161n67 CNV Loss 20364138
nsv821367 CNV Deletion 20802225
nsv514572 CNV Complex 21397061
nsv825457 CNV Loss 20364138
dgv162n67 CNV Loss 20364138
dgv153e199 CNV Deletion 23128226
esv2738206 CNV Deletion 23290073
esv29646 CNV Gain+Loss 19812545
nsv514573 CNV Complex 21397061
nsv467368 CNV Loss 19166990
nsv467369 CNV Loss 19166990
nsv895704 CNV Loss 21882294
dgv770n71 CNV Loss 21882294
nsv895706 CNV Loss 21882294
nsv895708 CNV Loss 21882294
nsv819483 CNV Gain 19587683
nsv517130 CNV Gain+Loss 19592680
nsv895709 CNV Loss 21882294
nsv895710 CNV Loss 21882294
nsv524058 CNV Loss 19592680

Relevant External Links for ADAMTS14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS14 Gene

Disorders for ADAMTS14 Gene

Relevant External Links for ADAMTS14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAMTS14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAMTS14 Gene

Publications for ADAMTS14 Gene

  1. Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family. (PMID: 11779638) Bolz H. … Kubisch C. (Biochim. Biophys. Acta 2001) 2 3 4 23
  2. Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis. (PMID: 15913795) Goertsches R. … Montalban X. (J. Neuroimmunol. 2005) 3 23 48
  3. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. (PMID: 11741898) Colige A. … Nusgens B.V. (J. Biol. Chem. 2002) 3 4
  4. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S. … Lopez-Otin C. (Gene 2002) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for ADAMTS14 Gene

Sources for ADAMTS14 Gene

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