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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS12 Gene

protein-coding   GIFtS: 50
GCID: GC05M033495

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 5 diseases affiliated with
ADAMTS12 via
MalaCards
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 Human Malady Compendium 
Biological research products
for ADAMTS12    

Aliases
for ADAMTS12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 121 2     PRO43892
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 121 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 122
ADAM-TS122 3     EC 3.4.24.-3
ADAMTS-122 3     EC 3.4.248
ADAM-TS 122 3     EC 3.4.24.828

External Ids:    HGNC: 146051   Entrez Gene: 817922   Ensembl: ENSG000001513887   OMIM: 6061845   UniProtKB: P583973   

Export aliases for ADAMTS12 gene to outside databases

Previous GC identifers: GC05M033471 GC05M033973 GC05M033572 GC05M033563


Summaries
for ADAMTS12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS12:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of
this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme
encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in
tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
Function: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and
aggregan. Has anti-tumorigenic properties

Gene Wiki entry for ADAMTS12


Genomic Views
for ADAMTS12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS12 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   Pax-5   MyoD   E2F-2   Roaz   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS12 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTS12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5q35

ADAMTS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS12 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M033495:  view genomic region     (about GC identifiers)

Start:
 33,523,640 bp from pter      End:
 33,892,297 bp from pter
Size:
 368,658 bases      Orientation:
 minus strand

Proteins
for ADAMTS12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor  
Size: 1594 amino acids; 177676 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with COMP
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: A2RRN9 A5D6V6 Q6UWL3
Alternative splicing: 3 isoforms:  P58397-1   P58397-2   P58397-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMTS12: NX_P58397

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase1
  • Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the
    • metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing
    the spacer 2 and four TSP type-1 domains1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P58397

    • 4/7 DME Specific Peptides for ADAMTS12 (P58397) (see all 7)
     LRPFHCQ  CHLRPCA  EDRCGVC  VWIQLLFQ 

    ADAMTS12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112217.2  
    ENSEMBL proteins: 
     ENSP00000422554   ENSP00000344847   ENSP00000421638  

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    Uscn Proteins for ADAMTS12

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--


    ADAMTS12 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAMTS12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS12 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry P58397

    ProtoNet protein and cluster: P58397

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 8 TSP type-1 domains


    Function
    for ADAMTS12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
    Function: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and
    aggregan. Has anti-tumorigenic properties
    Enzyme regulation: Inhibited by alpha-2 macroglobulin
    Biophysicochemical properties: pH dependence: Optimum pH is between 7.5 and 9.5 with COMP for substrate;
    Induction: By IFN-alpha and by IL1B/interleukin-1 beta. Up-regulated in articular cartilage and synovium from arthritis
    patients. Up-regulared in chondrocytes

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822 EC 3.4.242

    miRNA
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    Gene Editing
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--


    ADAMTS12 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Adamts12tm1Agno for ADAMTS12
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adamts12):
     cardiovascular system  tumorigenesis 

    ADAMTS12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAMTS12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS12

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    ADAMTS12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS12
    Search CenterWatch for drugs/clinical trials and news about ADAMTS12 / ATS12 

    Transcripts
    for ADAMTS12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS12 gene: 
    NM_030955.2  

    Unigene Cluster for ADAMTS12:

    ADAM metallopeptidase with thrombospondin type 1 motif, 12
    Hs.12680  [show with all ESTs]
    Unigene Representative Sequence: AJ250725
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504830(uc003jia.1 uc010iuq.1) ENST00000352040 ENST00000504582
    ENST00000506952 ENST00000515401(uc003jib.1) ENST00000509762

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    Clone
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    Additional cDNA sequence: 

    AJ250725.1 AK001058.1 AY358745.1 BC058841.1 BC131733.1 BC139900.1 

    5 DOTS entries:

    DT.413612  DT.92049058  DT.305178  DT.101980127  DT.120883771 

    24/36 AceView cDNA sequences (see all 36):

    AI675486 CA432475 BP372103 NM_030955 BI829756 BX280655 AW629511 BG108002 
    AW268575 AY358745 AL698043 AJ250725 BU934875 CD632932 AW271345 BG192901 
    BQ774480 BC058841 AI818415 BF510897 N93301 BG209298 AW938686 BF329257 

    GeneLoc Exon Structure


    Expression
    for ADAMTS12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGTAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTS12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Cartilage-like cells (Differentiation of s...)Cartilage

    See ADAMTS12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS12

    SOURCE GeneReport for Unigene cluster: Hs.12680

    UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
    Tissue specificity: Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely
    expressed in gastric carcinomas and in cancer cells of diverse origin

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    Orthologs
    for ADAMTS12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS12 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS121 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.38(n)
    62.92(a)    		   427428  XM_003642975.1  XP_003643023.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000039371 A disintegrin and metalloproteinase with thrombospondin more 60.86(n)
    56.77(a)    		   100003937  XM_001343335.3  XP_001343371.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG40961 , 3 metalloendopeptidase3
    CG40961    		 39(a)
    (best of 2)3
    49.9(n)1
    40.38(a)1    		   5B13
    314901  NM_132019.31  NP_572247.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea C37C3.6a3 protease inhibitor 35(a)
    (best of 3)    		   V(7829899-7835944)   --


    ENSEMBL Gene Tree for ADAMTS12 (if available)
    TreeFam Gene Tree for ADAMTS12 (if available) 

    Paralogs
    for ADAMTS12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS12 gene
    ADAMTS72  ADAMTS172  ADAMTS12  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  
    ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS152  ADAMTS162  ADAMTS92  ADAMTS82  ADAMTS32  
    ADAMTS102  
    12 SIMAP similar genes for ADAMTS12 using alignment to 2 protein entries:     ATS12_HUMAN (see all proteins):
    ADAMTS13    ADAMTS7    ADAMTS10    ADAMTS18    ADAMTS16    ADAMTS1
    ADAMTS17    ADAMTS8    DKFZp686E01144    ADAMTS4    ADAMTS6    ADAMTS15

    ADAMTS12 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6877 NCBI SNPs in ADAMTS12 are shown (see all 6877)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1910183661,2
    		--33526786(+) TCTGCC/GTGGAT 1 -- ds50010--------
    rs1410349751,2
    		--33526807(+) AATGTC/TCCTAA 1 -- ds50010--------
    rs1823654601,2
    		--33526818(+) AGCTCC/TGCTGT 1 -- ds50010--------
    rs1861267371,2
    		--33526864(+) CAAGAA/GAAAAA 1 -- ds50010--------
    rs168912801,2
    		C,F,H,--33526991(+) GGAGAA/GCAAAA 1 -- ds500116Minor allele frequency- G:0.04NA NS EA WA 1774
    rs1910403321,2
    		--33527142(+) GGTGGC/TTAGAG 1 -- ds50010--------
    rs1157739001,2
    		F,--33527155(+) ACACAA/GTGGAT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1827498591,2
    		--33527215(+) CTCAAC/TGAAGC 1 -- ds50010--------
    rs1471230801,2
    		C,--33527291(+) TTTGGG/ACTTAG 1 -- ut311Minor allele frequency- A:0.00NA 4552
    rs168912811,2
    		C,F,H,--33527307(+) TTTTGA/GCTTTT 2 P S mis1 ese326Minor allele frequency- G:0.09NA NS EA CSA WA EU 8346

    HapMap Linkage Disequilibrium report for ADAMTS12 (33523640 - 33773640 bp, first 250kb of ADAMTS12)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for ADAMTS12
         4 CNVs: 36402 2576 10109 23763
         4 Indels: 11252 69046 11253 69047

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    Disorders / Diseases
    for ADAMTS12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS12 for disorders           About GeneDecksing

    OMIM gene information: 606184    OMIM disorders: --

    5 diseases for ADAMTS12:    About MalaCards
    asthma    colon cancer    colorectal cancer    arthritis
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS12 (2 documents)

    Export disorders for ADAMTS12 gene to outside databases

    Publications
    for ADAMTS12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS12 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ADAMTS12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. (PubMed id 11279086)1, 2, 3 Cal S.... Lopez-Otin C. (2001)
    2. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. (PubMed id 17895370)1, 2 Llamazares M.... Cal S. (2007)
    3. ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. (PubMed id 16611630)1, 2 Liu C.J....Di Cesare P.E. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PubMed id 18485748)2, 9 Luan Y.... Liu C.-J. (2008)
    7. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PubMed id 19098927)1, 9 Liu C.J. (2009)
    8. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. (PubMed id 19151918)1, 9 Bai X.H....Liu C.J. (2009)
    9. Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation. (PubMed id 22247065)1 Zhang Q....Wang Y. (2012)
    10. Genetic variations in the ADAMTS12 gene are associated with schizophrenia in Puerto Rican patients of Spanish descent. (PubMed id 22322903)1 Bespalova I.N....Silverman J.M. (2012)

    External Searches for ADAMTS12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ADAMTS12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81792 HGNC: 14605 AceView: ADAMTS12 Ensembl:ENSG00000151388 euGenes: HUgn81792
    ECgene: ADAMTS12 H-InvDB: ADAMTS12

    Other Databases showing ADAMTS12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMTS12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAMTS12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS12 gene:
    Search GeneIP for patents involving ADAMTS12

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