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ADAMTS12 Gene

protein-coding   GIFtS: 56
GCID: GC05M033495

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 121 2     PRO43892
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 121 2
     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 122
ADAM-TS122 3     EC 3.4.24.-3
ADAMTS-122 3     EC 3.4.248
ADAM-TS 122 3     EC 3.4.24.828

External Ids:    HGNC: 146051   Entrez Gene: 817922   Ensembl: ENSG000001513887   OMIM: 6061845   UniProtKB: P583973   

Export aliases for ADAMTS12 gene to outside databases

Previous GC identifers: GC05M033471 GC05M033973 GC05M033572 GC05M033563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTS12 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members
of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The
enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal
development or in tumor processes through its proteolytic activity or as a molecule potentially involved in
regulation of cell adhesion. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS12 Gene:
ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif, 12) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTSL4.

UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
Function: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and
aggregan. Has anti-tumorigenic properties

Gene Wiki entry for ADAMTS12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  NT_187551.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS12 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   Pax-5   MyoD   E2F-2   Roaz   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS12 promoter sequence
   Search Chromatin IP Primers for ADAMTS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5q35

ADAMTS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS12 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M033495:  view genomic region     (about GC identifiers)

Start:
33,523,640 bp from pter      End:
33,892,297 bp from pter
Size:
368,658 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor  
Size: 1594 amino acids; 177676 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with COMP
Secondary accessions: A2RRN9 A5D6V6 Q6UWL3
Alternative splicing: 3 isoforms:  P58397-1   P58397-2   P58397-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMTS12: NX_P58397

Explore proteomics data for ADAMTS12 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase1
  • Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the
    metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment
    containing the spacer 2 and four TSP type-1 domains1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Glycosylation2 at Asn105, Asn125, Asn215, Asn485, Asn685, Asn790, Asn952, Asn1105, Asn1276, Asn1301,
                                 Asn1321, Asn1372, Asn1379, Asn1504
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAMTS12 (P58397) (see all 7)
     LRPFHCQ  CHLRPCA  EDRCGVC  VWIQLLFQ 


    See ADAMTS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112217.2  
    ENSEMBL proteins: 
     ENSP00000422554   ENSP00000344847   ENSP00000421638  
    Reactome Protein details: P58397

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS12
    ADAMTS family

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010909 PLAC
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry P58397

    ProtoNet protein and cluster: P58397

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix (By similarity)
    Domain: The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 8 TSP type-1 domains


    Find genes that share domains with ADAMTS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS12_HUMAN, P58397
    Function: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and
    aggregan. Has anti-tumorigenic properties
    Enzyme regulation: Inhibited by alpha-2 macroglobulin
    Biophysicochemical properties: pH dependence: Optimum pH is between 7.5 and 9.5 with COMP for substrate;
    Induction: By IFN-alpha and by IL1B/interleukin-1 beta. Up-regulated in articular cartilage and synovium from
    arthritis patients. Up-regulared in chondrocytes

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IDA16611630
    GO:0005515protein binding IPI16611630
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS12           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adamts12):
     cardiovascular system  tumorigenesis 

    Find genes that share phenotypes with ADAMTS12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adamts12tm1Agno for ADAMTS12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS12
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATS12_HUMAN, P58397: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix IDA11279086

    Find genes that share ontologies with ADAMTS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with ADAMTS12           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAMTS12
        O-glycosylation of TSR domain-containing proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTS12
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTS12

    2 Interacting proteins for ADAMTS12 (P583971) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMPP497471EBI-9028051,EBI-2531022
    CompQ9R0G61EBI-9028051,EBI-9028018
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007160cell-matrix adhesion IMP--
    GO:0016477cell migration IMP--
    GO:0030167proteoglycan catabolic process IDA17895370
    GO:0032331negative regulation of chondrocyte differentiation IDA--

    Find genes that share ontologies with ADAMTS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTS12 (ATS12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMTS12 gene: 
    NM_030955.2  

    Unigene Cluster for ADAMTS12:

    ADAM metallopeptidase with thrombospondin type 1 motif, 12
    Hs.12680  [show with all ESTs]
    Unigene Representative Sequence: AJ250725
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504830(uc003jia.1 uc010iuq.1) ENST00000352040 ENST00000504582
    ENST00000506952 ENST00000515401(uc003jib.1) ENST00000509762
    miRNA
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    Additional mRNA sequence: 

    AJ250725.1 AK001058.1 AY358745.1 BC058841.1 BC131733.1 BC139900.1 

    5 DOTS entries:

    DT.413612  DT.92049058  DT.305178  DT.101980127  DT.120883771 

    Selected AceView cDNA sequences (see all 36):

    CA432475 BP372103 BI829756 AI675486 NM_030955 BX280655 BG192901 AW271345 
    BF510897 BQ774480 BC058841 AI818415 AW268575 AL698043 BG108002 CD632932 
    BU934875 N93301 AJ250725 AW629511 AY358745 W25153 AI039653 BE273010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTAAAG
    ADAMTS12 Expression
    About this image


    ADAMTS12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    ADAMTS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12680

    UniProtKB/Swiss-Prot: ATS12_HUMAN, P58397
    Tissue specificity: Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely
    expressed in gastric carcinomas and in cancer cells of diverse origin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts121 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 82.53(n)1
    81.07(a)1
      15 (5.43 cM)5
    2393371  NM_175501.21  NP_780710.21 
     110647905 
    chicken
    (Gallus gallus)
    Aves ADAMTS121 ADAM metallopeptidase with thrombospondin type 1 motif, more 66.42(n)
    62.68(a)
      427428  XM_003642975.2  XP_003643023.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    30(a)
    20(a)
    many ↔ many
    many ↔ many
    2(10454625-10484852)
    GL343210.1(1329539-1368376)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts121 ADAM metallopeptidase with thrombospondin type 1 motif, more 61.89(n)
    59.31(a)
      100380018  XM_002942444.2  XP_002942490.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000039371 A disintegrin and metalloproteinase with thrombospondin more 57.88(n)
    52.31(a)
      100003937  XM_001343335.4  XP_001343371.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40963 metalloendopeptidase 39(a)
    (best of 2)
      5B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C37C3.6a3 protease inhibitor 35(a)
    (best of 3)
      V(7829899-7835944)   --


    ENSEMBL Gene Tree for ADAMTS12 (if available)
    TreeFam Gene Tree for ADAMTS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTS12 gene
    ADAMTSL42  ADAMTS72  ADAMTS132  THSD42  ADAMTSL22  PAPLN2  ADAMTSL52  ADAMTSL12  
    ENSG000002156162  ADAMTSL32  
    11 SIMAP similar genes for ADAMTS12 using alignment to 2 protein entries:     ATS12_HUMAN (see all proteins):
    ADAMTS13    ADAMTS7    ADAMTS10    ADAMTS18    ADAMTS16    ADAMTS1
    ADAMTS17    ADAMTS8    DKFZp686E01144    ADAMTS4    ADAMTS6

    Find genes that share paralogs with ADAMTS12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTS12 (see all 7991)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168918621,2,,4
    C,F,Huntested133881385(+) TCCTTA/C/GATTGA 2 Q * stg111NA NS EA CSA WA 5230
    rs1910183661,2
    --33526786(+) TCTGCC/GTGGAT 1 -- ds50010--------
    rs1410349751,2
    --33526807(+) AATGTC/TCCTAA 1 -- ds50010--------
    rs1823654601,2
    C--33526818(+) AGCTCC/TGCTGT 1 -- ds50010--------
    rs1861267371,2
    --33526864(+) CAAGAA/GAAAAA 1 -- ds50010--------
    rs168912801,2
    C,F,H--33526991(+) GGAGAA/GCAAAA 1 -- ds500116Minor allele frequency- G:0.04NA NS EA WA 1774
    rs1124909691,2
    C--33527128(+) TGTGAG/AGGACA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1125750271,2
    C--33527137(+) CATTCG/AGTGGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1910403321,2
    --33527142(+) GGTGGC/TTAGAG 1 -- ds50010--------
    rs1157739001,2
    F--33527155(+) ACACAA/GTGGAT 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for ADAMTS12 (33523640 - 33773640 bp, first 250kb of ADAMTS12)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAMTS12 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730048CNV Deletion23290073
    esv2306417CNV Deletion18987734
    esv2730052CNV Deletion23290073
    esv2730049CNV Deletion23290073
    esv2623201CNV Deletion19546169
    esv2730050CNV Deletion23290073
    esv989506CNV Deletion20482838
    esv2659139CNV Deletion23128226
    nsv4782CNV Insertion18451855
    esv270198CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS12
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606184    OMIM disorders: --


    Find genes that share disorders with ADAMTS12           About GenesLikeMe

    Genetic Association Database (GAD): ADAMTS12
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS12 (2 documents)

    Export disorders for ADAMTS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTS12 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ADAMTS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. (PubMed id 11279086)1, 2, 3 Cal S.... Lopez-Otin C. (J. Biol. Chem. 2001)
    2. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PubMed id 18485748)1, 2, 9 Luan Y.... Liu C.-J. (Osteoarthritis Cartilage 2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. (PubMed id 20400778)1, 4 Morrison A.C....Smith N.L. (Circ Cardiovasc Genet 2010)
    5. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. (PubMed id 17895370)1, 2 Llamazares M.... Cal S. (J. Cell Sci. 2007)
    6. ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. (PubMed id 16611630)1, 2 Liu C.-J.... Di Cesare P.E. (J. Biol. Chem. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PubMed id 19098927)1, 9 Liu C.J. (Nat Clin Pract Rheumatol 2009)
    10. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. (PubMed id 19151918)1, 9 Bai X.H....Liu C.J. (Cell. Mol. Life Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81792 HGNC: 14605 AceView: ADAMTS12 Ensembl:ENSG00000151388 euGenes: HUgn81792
    ECgene: ADAMTS12 H-InvDB: ADAMTS12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTS12 gene:
    Search GeneIP for patents involving ADAMTS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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