Aliases for ADAMTS10 Gene
External Ids for ADAMTS10 Gene
Previous GeneCards Identifiers for ADAMTS10 Gene
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS10 Gene
ADAMTS10 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10) is a Protein Coding gene. Diseases associated with ADAMTS10 include weill-marchesani syndrome 1, recessive and weill-marchesani syndrome. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.
UniProtKB/Swiss-Prot for ADAMTS10 Gene
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.