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Aliases for ADAMTS10 Gene

Aliases for ADAMTS10 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 10 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 10 2 3
  • ADAM-TS 10 3 4
  • ADAM-TS10 3 4
  • ADAMTS-10 3 4
  • WMS1 3 6
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10 3
  • Zinc Metalloendopeptidase 3
  • EC 3.4.24.82 64
  • EC 3.4.24.- 4
  • WMS 3

External Ids for ADAMTS10 Gene

Summaries for ADAMTS10 Gene

Entrez Gene Summary for ADAMTS10 Gene

  • This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS10 Gene

ADAMTS10 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 10) is a Protein Coding gene. Diseases associated with ADAMTS10 include weill-marchesani syndrome and weill-marchesani syndrome 1, recessive. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS10 Gene

  • Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.

Gene Wiki entry for ADAMTS10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS10 Gene

Genomics for ADAMTS10 Gene

Genomic Location for ADAMTS10 Gene

Start:
8,580,240 bp from pter
End:
8,610,753 bp from pter
Size:
30,514 bases
Orientation:
Minus strand

Genomic View for ADAMTS10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS10 Gene

Regulatory Elements for ADAMTS10 Gene

Proteins for ADAMTS10 Gene

  • Protein details for ADAMTS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H324-ATS10_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 10
    Protein Accession:
    Q9H324
    Secondary Accessions:
    • M0QZE4

    Protein attributes for ADAMTS10 Gene

    Size:
    1103 amino acids
    Molecular mass:
    120874 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with FBN1; this interaction promotes microfibrils assembly.

    Alternative splice isoforms for ADAMTS10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS10 Gene

Proteomics data for ADAMTS10 Gene at MOPED

Selected DME Specific Peptides for ADAMTS10 Gene

Post-translational modifications for ADAMTS10 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn90, Asn222, Asn323, Asn740, Asn795, and Asn892

Other Protein References for ADAMTS10 Gene

Domains for ADAMTS10 Gene

Gene Families for ADAMTS10 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

UniProtKB/Swiss-Prot:

ATS10_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.:
    • Q9H324
  • Contains 1 disintegrin domain.:
    • Q9H324
  • Contains 1 peptidase M12B domain.:
    • Q9H324
  • Contains 1 PLAC domain.:
    • Q9H324
  • Contains 5 TSP type-1 domains.:
    • Q9H324
genes like me logo Genes that share domains with ADAMTS10: view

Function for ADAMTS10 Gene

Molecular function for ADAMTS10 Gene

UniProtKB/Swiss-Prot Function: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.

Enzyme Numbers (IUBMB) for ADAMTS10 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 21402694
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS10: view

Phenotypes for ADAMTS10 Gene

genes like me logo Genes that share phenotypes with ADAMTS10: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMTS10 Gene

Localization for ADAMTS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS10 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS10 Gene COMPARTMENTS Subcellular localization image for ADAMTS10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001527 microfibril IDA 21402694
GO:0031012 extracellular matrix IDA 21402694
genes like me logo Genes that share ontologies with ADAMTS10: view

Pathways for ADAMTS10 Gene

SuperPathways for ADAMTS10 Gene

Superpath Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAMTS10: view

Pathways by source for ADAMTS10 Gene

1 Sino Biological pathway for ADAMTS10 Gene

Gene Ontology (GO) - Biological Process for ADAMTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ADAMTS10: view

Transcripts for ADAMTS10 Gene

Unigene Clusters for ADAMTS10 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: - -
SP8:
SP9: - - -
SP10:
SP11: -
SP12:
SP13: -
SP14:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ADAMTS10 Gene

GeneLoc Exon Structure for
ADAMTS10
ECgene alternative splicing isoforms for
ADAMTS10

Expression for ADAMTS10 Gene

mRNA expression in normal human tissues for ADAMTS10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAMTS10 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS10 Gene Hs.657508

mRNA Expression by UniProt/SwissProt for ADAMTS10 Gene

Q9H324-ATS10_HUMAN
Tissue specificity: Widely expressed in adult tissues.
genes like me logo Genes that share expressions with ADAMTS10: view

Orthologs for ADAMTS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS10 36
  • 99.52 (n)
  • 99.64 (a)
ADAMTS10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS10 36
  • 90.02 (n)
  • 95.92 (a)
ADAMTS10 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS10 36
  • 90.44 (n)
  • 95.64 (a)
ADAMTS10 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts10 36
  • 87.14 (n)
  • 94.28 (a)
Adamts10 16
Adamts10 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS10 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts10 36
  • 87.66 (n)
  • 94.56 (a)
chicken
(Gallus gallus)
Aves ADAMTS10 36
  • 72.14 (n)
  • 74.23 (a)
ADAMTS10 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS10 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts10 36
  • 66.33 (n)
  • 69.24 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts10 36
  • 67.6 (n)
  • 67.82 (a)
adamts10 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14869 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gon-1 37
  • 16 (a)
OneToMany
C37C3.6a 38
  • 35 (a)
C37C3.6b 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for ADAMTS10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS10 Gene

ENSEMBL:
Gene Tree for ADAMTS10 (if available)
TreeFam:
Gene Tree for ADAMTS10 (if available)

Paralogs for ADAMTS10 Gene

Selected SIMAP similar genes for ADAMTS10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADAMTS10: view

Variants for ADAMTS10 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3814291 - 8,605,091(+) GGGGC(C/T)GGGCC missense, reference, utr-variant-5-prime, nc-transcript-variant
rs3923268 -- 8,590,032(-) TCCCC(C/T)CAAGC intron-variant
rs3924927 -- 8,597,975(-) TTAGG(C/T)GGGCA intron-variant, upstream-variant-2KB
rs3936234 -- 8,595,120(+) GAATC(A/G)AGGCA intron-variant
rs4147472 -- 8,609,101(+) TGTCA(G/T)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS10 Gene

Variant ID Type Subtype PubMed ID
nsv911018 CNV Loss 21882294
esv2677021 CNV Deletion 23128226
esv2667281 CNV Deletion 23128226

Relevant External Links for ADAMTS10 Gene

HapMap Linkage Disequilibrium report
ADAMTS10
Human Gene Mutation Database (HGMD)
ADAMTS10

Disorders for ADAMTS10 Gene

(1) OMIM Diseases for ADAMTS10 Gene (608990)

UniProtKB/Swiss-Prot

ATS10_HUMAN
  • Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]: A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. {ECO:0000269 PubMed:15368195, ECO:0000269 PubMed:18567016}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADAMTS10 Gene

Relevant External Links for ADAMTS10

GeneTests
ADAMTS10
GeneReviews
ADAMTS10
Genetic Association Database (GAD)
ADAMTS10
genes like me logo Genes that share disorders with ADAMTS10: view

Publications for ADAMTS10 Gene

  1. Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. (PMID: 15355968) Somerville R.P.T. … Apte S.S. (J. Biol. Chem. 2004) 3 4 23
  2. ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome. (PMID: 15368195) Dagoneau N. … Cormier-Daire V. (Am. J. Hum. Genet. 2004) 3 4 23
  3. Clinical and genetic investigation of isolated microspherophakia in a consanguineous Tunisian family. (PMID: 19696795) Ben Yahia S. … Khairallah M. (J. Hum. Genet. 2009) 3 23
  4. Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. (PMID: 19836009) Morales J. … Al Tassan N. (Am. J. Hum. Genet. 2009) 3 23
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 49

Products for ADAMTS10 Gene

Sources for ADAMTS10 Gene

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