ADAMTS10 Gene
protein-coding GIFtS: 55
GCID: GC19M008645
|
|
ADAM metallopeptidase with thrombospondin type 1 motif,...(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
| |
Aliases
for ADAMTS10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 101 2 | | WMS12 | | ADAM-TS101 2 3 | | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 102 | | A Disintegrin-Like And Metalloprotease (Reprolysin Type) With ThrombospondinType 1 Motif, 101 2 | | Zinc Metalloendopeptidase2 | | ADAMTS-102 3 | | EC 3.4.24.-3 | | ADAM-TS 102 3 | | EC 3.4.24.828 | | WMS2 5 | | |
Export aliases for ADAMTS10 gene to outside databasesPrevious GC identifers: GC19M008673 GC19M008859 GC19M008540 GC19M008551 GC19M008300 |
Summaries
for ADAMTS10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAMTS10:
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) familyof zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain ofthe reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least onethrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization,coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role ingrowth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesanisyndrome. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ATS10_HUMAN, Q9H324Function: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix componentsoccurring independently or along with elastin in the formation of elastic tissues
Gene Wiki entry for ADAMTS10
|
Genomic Views
for ADAMTS10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAMTS10 gene promoter:
SREBP-1c ATF-2 Bach2 Olf-1 SREBP-1b YY1 CRE-BP1 MEF-2A SREBP-1a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAMTS10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3ADAMTS10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M008645: view genomic region
(about GC identifiers)
Start:
|
8,645,126 bp from pter |
End:
|
8,675,588 bp from pter |
Size:
|
30,463 bases |
Orientation:
|
minus strand |
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Proteins
for ADAMTS10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATS10_HUMAN, Q9H324 (See
protein sequence)Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor Size: 1103 amino acids; 120874 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with FBN1; this interaction promotes microfibrils assembly
Subcellular location: Secreted, extracellular space, extracellular matrixExplore the universe of human proteins at neXtProt for ADAMTS10: NX_Q9H324
Post-translational modifications:
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequenceC1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of therepeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucoseresidue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequenceW-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H324
3 DME Specific Peptides for ADAMTS10 (Q9H324)
ADAMTS10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112219.2
ENSEMBL proteins: ENSP00000270328
Human Recombinant Protein Products for ADAMTS10:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ADAMTS10 for ontologies About GeneDecksing
ADAMTS10 Antibody Products:
Assay Products for ADAMTS10: |
Protein
Domains /
Families
for ADAMTS10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAMTS10 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9H324ProtoNet protein and cluster: Q9H324 5 Blocks protein families: IPB000884 Thrombospondin IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB008085 Thrombospondin type 1 repeat signature IPB010294 ADAM-TS Spacer 1
UniProtKB/Swiss-Prot: ATS10_HUMAN, Q9H324Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellularmatrix (By similarity)Similarity: Contains 1 disintegrin domainSimilarity: Contains 1 peptidase M12B domainSimilarity: Contains 1 PLAC domainSimilarity: Contains 5 TSP type-1 domains |
Function
for ADAMTS10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ATS10_HUMAN, Q9H324Function: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix componentsoccurring independently or along with elastin in the formation of elastic tissues Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.822
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ADAMTS10 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ADAMTS10:
1 MGI phenotypic allele  for Adamts10 (no phenotypes)
ADAMTS10 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADAMTS10 (NM_030957) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS10 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS10 |
|
Pathways & Interactions
for ADAMTS10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS10
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/8 Interacting proteins for ADAMTS10 (Q9H3242, 3 ENSP000002703284) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ADAMTS10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAMTS10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAMTS10
Search CenterWatch for drugs/clinical trials and news about ADAMTS10 / ATS10
|
Transcripts
for ADAMTS10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAMTS10 gene: NM_030957.2 Unigene Cluster for ADAMTS10: ADAM metallopeptidase with thrombospondin type 1 motif, 10 Hs.657508 [show with all ESTs]Unigene Representative Sequence: NM_0309571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000270328(uc002mki.1 uc002mkj.1 uc002mkk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAMTS10 (NM_030957) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS10 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS10 |
Additional cDNA sequence: AB209515.1 AF163762.1 AK131414.1 BC029308.1 10 DOTS entries: DT.442314 DT.97791858 DT.121410706 DT.100743381 DT.436881 DT.75155302 DT.100738095 DT.40130375 DT.100698017 DT.91907731 24/133 AceView cDNA sequences (see all 133): AI871149 BU727601 AI673039 CD632939 BM671015 BM709180 CD632961 AI271540 AI131032 BC029308 AW183873 CA396141 CD632954 AI741177 CD632967 NM_030957 BF515795 W20333 CD632963 CD632962 AA583837 Z45375 AI934923 BX336652
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS10 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADAMTS10
|
Expression
for ADAMTS10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAMTS10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTACAGA
About this image
See ADAMTS10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAMTS10
SOURCE GeneReport for Unigene cluster: Hs.657508
UniProtKB/Swiss-Prot: ATS10_HUMAN, Q9H324Tissue specificity: Widely expressed in adult tissues
SABiosciences Custom PCR Arrays for ADAMTS10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS10 |
Orthologs
for ADAMTS10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADAMTS10 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADAMTS101 |
ADAM metallopeptidase with thrombospondin type 1 motif, more |
72.17(n)
74.32(a) |
|
769592 XM_001232249.2 XP_001232250.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ADAMTS106 |
-- |
71(a) |
1 ↔ 1 |
AAWZ02038110(435-10115) |
zebrafish
(Danio rerio) |
Actinopterygii |
adamts101 |
ADAM metallopeptidase with thrombospondin type 1 motif, more |
67.75(n)
68.1(a) |
|
564734 NM_001123274.1 NP_001116746.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ppn6 |
Papilin |
7(a) |
possible ortholog |
3R(24346387-24366053) |
worm
(Caenorhabditis elegans) |
Secernentea |
C37C3.6a3 |
protease inhibitor |
35(a)
(best of 2) |
|
V(7829899-7835944) -- |
ENSEMBL Gene Tree for ADAMTS10 (if available)
TreeFam Gene Tree for ADAMTS10 (if available) |
Paralogs
for ADAMTS10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAMTS10 gene
- ADAMTS72 ADAMTS172 ADAMTS12 ADAMTS182 ADAMTS192 ADAMTS62 ADAMTS122 ADAMTS142
- ADAMTS22 ADAMTS202 ADAMTS52 ADAMTS42 ADAMTS152 ADAMTS162 ADAMTS92 ADAMTS82
- ADAMTS32
8 SIMAP similar genes for ADAMTS10 using alignment to 5 protein entries: ATS10_HUMAN (see all proteins):ADAMTS6 ADAMTS12 ADAMTS7 ADAMTS16 ADAMTS18 ADAMTS1
DKFZp686E01144 ADAMTS20
ADAMTS10 for paralogs About GeneDecksing
|
Genomic Variants
for ADAMTS10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAMTS10 (8645126 - 8675588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAMTS10: --
Human Gene Mutation Database (HGMD): ADAMTS10
| 2 SABiosciences Cancer Mutation PCR Assays for ADAMTS10: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS10 |
|
Disorders
/ Diseases
for ADAMTS10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAMTS10 for disorders About GeneDecksing
OMIM gene information: 608990
OMIM disorders: 277600
UniProtKB/Swiss-Prot: ATS10_HUMAN, Q9H324
Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]. WMS1 is a rareconnective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalitiesincluding microspherophakia, ectopia lentis, severe myopia and glaucoma
9  diseases for ADAMTS10: About MalaCardsweill-marchesani syndrome weill-marchesani syndrome, recessive ectopia lentis tracheal stenosis
short stature arthritis brachydactyly glaucoma
myopia
1 disease from the University of Copenhagen DISEASES database for ADAMTS10:Weill-Marchesani syndrome GeneTests: ADAMTS10
Weill-Marchesani Syndrome
Export disorders for ADAMTS10 gene to outside databases
|
Publications
for ADAMTS10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAMTS10 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with ADAMTS10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. (PubMed id 15355968)1, 2, 9 Somerville R.P....Apte S.S. (2004)
- ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome. (PubMed id 15368195)1, 2, 9 Dagoneau N....Cormier-Daire V. (2004)
- ADAMTS10 protein interacts with fibrillin-1 and promo tes its deposition in extracellular matrix of cultured fibroblasts. (PubMed id 21402694)1, 2 Kutz W.E....Apte S.S. (2011)
- Functional analysis of an ADAMTS10 signal peptide mutation in Weill- Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme. (PubMed id 18567016)1, 2 Kutz W.E.... Apte S.S. (2008)
- Homozygous mutations in ADAMTS10 and ADAMTS17 cause l enticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. (PubMed id 19836009)1, 9 Morales J....Al Tassan N. (2009)
- Clinical and genetic investigation of isolated micros pherophakia in a consanguineous Tunisian family. (PubMed id 19696795)1, 9 Ben Yahia S....Khairallah M. (2009)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
- ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. (PubMed id 15358598)1 Charrier L....Merlin D. (2005)
|
External Searches for ADAMTS10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAMTS10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAMTS10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAMTS10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAMTS10 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ADAMTS10 |
|
| | |
About This Section
| Patent Information for ADAMTS10 gene:
Search GeneIP for patents involving ADAMTS10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADAMTS10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAMTS10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS10 | | | OriGene Protein Over-expression Lysate for ADAMTS10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAMTS10 | | OriGene 3'-UTR Clone for ADAMTS10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADAMTS10 | | OriGene Custom Protein Services for ADAMTS10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS10 |
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 | | | ADAMTS10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS10 |
|  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS10 |
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