Aliases for ADAMTS10 Gene
External Ids for ADAMTS10 Gene
Previous GeneCards Identifiers for ADAMTS10 Gene
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAMTS10 Gene
ADAMTS10 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10) is a Protein Coding gene. Diseases associated with ADAMTS10 include weill-marchesani syndrome 1, recessive and weill-marchesani syndrome. Among its related pathways are Notch Signaling Pathway (sino) and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS20.
UniProtKB/Swiss-Prot for ADAMTS10 Gene
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.