Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADAMTS1 Gene

protein-coding   GIFtS: 70
GCID: GC21M028208

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
  See ADAMTS1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 11 2     C3-C52
METH12 3 5     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 11 2
     EC 3.4.24.-3
Human Metalloproteinase With Thrombospondin Type 1 Motifs2 11     KIAA13463
ADAM-TS12 3     EC 3.4.248
ADAMTS-12 3     EC 3.4.24.148
METH-12 3     EC 3.4.24.828
ADAM-TS 12 3     

External Ids:    HGNC: 2171   Entrez Gene: 95102   Ensembl: ENSG000001547347   OMIM: 6051745   UniProtKB: Q9UHI83   

Export aliases for ADAMTS1 gene to outside databases

Previous GC identifers: GC21M024787 GC21M027130 GC21M013613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADAMTS1 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic
activity. The expression of this gene may be associated with various inflammatory processes as well as
development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ
morphology and function. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS1 Gene:
ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) is a protein-coding gene. Diseases associated with ADAMTS1 include type 2a von willebrand disease. GO annotations related to this gene include metallopeptidase activity and heparin binding. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory
processes as well as development of cancer cachexia. May play a critical role in follicular rupture

Gene Wiki entry for ADAMTS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTS1 gene promoter:
         Sp1   ATF-2   POU6F1 (c2)   Nkx2-5   HNF-3beta   RORalpha2   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS1 promoter sequence

   Search Chromatin IP Primers for ADAMTS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q21.3
ADAMTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M028208:   GeneLoc Nature:405,311-319
Start:
28,208,066 bp from pter       13,786,471 bp from centromere
End:
28,217,728 bp from pter 13,795,380 bp from centromere
Size:
9,663 bases 8,910 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF170084
genomic clones: KB2043D3 KB126A3


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor  
Size: 967 amino acids; 105358 Da
Cofactor: Binds 1 zinc ion per subunit
Sequence caution: Sequence=AAD48080.1; Type=Erroneous initiation; Sequence=BAA92584.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for ADAMTS1:
2JIH (3D)        2V4B (3D)        3Q2G (3D)        3Q2H (3D)    
Secondary accessions: D3DSD5 Q9NSJ8 Q9P2K0 Q9UH83 Q9UP80

Explore the universe of human proteins at neXtProt for ADAMTS1: NX_Q9UHI8

Explore proteomics data for ADAMTS1 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)1
  • Ubiquitination2 at Lys735
  • Glycosylation2 at Thr170, Thr197, Thr208, Asn547, Asn720, Asn764
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAMTS1 (Q9UHI8) (see all 14)
     SCSVIED  PWGDCSR  KHPSIRN  VIEDDGL 


    See ADAMTS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008919.3  
    ENSEMBL proteins: 
     ENSP00000284984   ENSP00000429557   ENSP00000403404   ENSP00000431065  
    Reactome Protein details: Q9UHI8

    ADAMTS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADAMTS1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAMTS1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAMTS1
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS1
    Novus Biologicals ADAMTS1 Proteins
    Novus Biologicals ADAMTS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMTS1

     
    Search eBioscience for Proteins for ADAMTS1 

    ADAMTS1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS1
    R&D Systems Antibodies for ADAMTS1
    Cell Signaling Technology (CST) Antibodies for ADAMTS1 
    OriGene Antibodies for ADAMTS1
    OriGene Custom Antibody Services for ADAMTS1
    Novus Biologicals ADAMTS1 Antibodies
    Abcam antibodies for ADAMTS1
    Cloud-Clone Corp. Antibodies for ADAMTS1
    ThermoFisher Antibodies for ADAMTS1
    LSBio Antibodies in human, mouse, rat for ADAMTS1

    ADAMTS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAMTS1
    R&D Systems ELISAs for ADAMTS1         (see all)
    GenScript Custom Assay Services for ADAMTS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAMTS1
    Cloud-Clone Corp. CLIAs for ADAMTS1
    Search eBioscience for ELISAs for ADAMTS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS1
    ADAMTS family

    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1

    Graphical View of Domain Structure for InterPro Entry Q9UHI8

    ProtoNet protein and cluster: Q9UHI8

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains


    Find genes that share domains with ADAMTS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS1_HUMAN, Q9UHI8
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
    angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory
    processes as well as development of cancer cachexia. May play a critical role in follicular rupture
    Catalytic activity: Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment
    domain

         Genatlas biochemistry entry for ADAMTS1:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular
    matrix protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth
    factor induced angiogenesis

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
    GO:0008237metallopeptidase activity TAS10438512
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTS1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADAMTS1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adamts1):
     adipose tissue  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging 
     renal/urinary system  reproductive system 

    Find genes that share phenotypes with ADAMTS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADAMTS1: Adamts1tm1Mapr Adamts1tm1Hku Adamts1tm1Mlia

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAMTS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADAMTS1:
    hsa-mir-124-3p (MIRT022469), hsa-mir-615-3p (MIRT040291), hsa-mir-26b-5p (MIRT029236), hsa-mir-92a-3p (MIRT049047), hsa-mir-877-3p (MIRT036972)

    Block miRNA regulation of human, mouse, rat ADAMTS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAMTS1 (see all 57):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-let-7d hsa-miR-548k hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAMTS1
    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAMTS1

    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS1 (see all 6)
    OriGene ORF clones in mouse, rat for ADAMTS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988)
    Sino Biological Human cDNA Clone for ADAMTS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAMTS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAMTS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATS1_HUMAN, Q9UHI8: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0031012extracellular matrix ----
    GO:0031410cytoplasmic vesicle IEA--

    Find genes that share ontologies with ADAMTS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADAMTS1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    3Notch Signaling Pathway (sino)
    Notch Signaling Pathway
    4Endochondral Ossification
    Endochondral Ossification
    5Angiogenesis (CST)
    Angiogenesis


    Find genes that share SuperPaths with ADAMTS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ADAMTS1
        Angiogenesis
    Adhesion

    1 BioSystems Pathway for ADAMTS1
        Endochondral Ossification

    1 Sino Biological Pathway for ADAMTS1
        Notch Signaling Pathway

    2 Reactome Pathways for ADAMTS1
        O-glycosylation of TSR domain-containing proteins
    Degradation of the extracellular matrix


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAMTS1: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADAMTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ADAMTS1 (Q9UHI83 ENSP000002849844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001822kidney development IEA--
    GO:0006508proteolysis ----
    GO:0007229integrin-mediated signaling pathway TAS8995297
    GO:0008285negative regulation of cell proliferation TAS10438512

    Find genes that share ontologies with ADAMTS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADAMTS1
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTS1 (ATS1)

    2 HMDB Compounds for ADAMTS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin sulfateChondritinsulfate (see all 12)9007-28-7--

    6 Novoseek inferred chemical compound relationships for ADAMTS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 41.3 3 15599946 (3)
    forskolin 11.6 1 11108265 (1)
    thymidine 0 1 16936124 (1)
    progesterone 0 3 14664708 (2)
    serine 0 1 15972109 (1)
    heparin 0 2 9593739 (1)

    1 PharmGKB related drug/compound annotation for ADAMTS1 gene    About this table
    Drug/compound PharmGKB Annotation
    pravastatinCA  



    Find genes that share compounds with ADAMTS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADAMTS1 gene: 
    NM_006988.3  

    Unigene Cluster for ADAMTS1:

    ADAM metallopeptidase with thrombospondin type 1 motif, 1
    Hs.643357  [show with all ESTs]
    Unigene Representative Sequence: NM_006988
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284984(uc002ymf.3) ENST00000464589 ENST00000492656 ENST00000517777
    ENST00000451462 ENST00000517452
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADAMTS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAMTS1 (see all 57):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-let-7d hsa-miR-548k hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADAMTS1
    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS1
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAMTS1 (see all 6)
    OriGene ORF clones in mouse, rat for ADAMTS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADAMTS1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1
      QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
      QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1

    Additional mRNA sequence: 

    AB037767.1 AF060152.1 AF170084.1 AF207664.1 AK129873.1 AK314475.1 AL162080.1 AL355723.1 
    AL355724.1 BC036515.2 BX647388.1 DQ108407.1 

    8 DOTS entries:

    DT.318280  DT.101981770  DT.95189320  DT.100791687  DT.100791688  DT.97846508  DT.121133409  DT.80100485 

    Selected AceView cDNA sequences (see all 343):

    BQ893675 T40492 H89565 AI689182 CA448387 BU619583 T41173 CA448974 
    AW474740 BQ029234 AI692832 BI789256 BQ021551 BI964112 CA447318 BU689133 
    W92831 BM994458 AA918632 NM_006988 AI089584 AA031474 BM068721 BQ009406 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                       
    SP2:                                                            


    ECgene alternative splicing isoforms for ADAMTS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADAMTS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTTATAA
    ADAMTS1 Expression
    About this image


    ADAMTS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Rib
             HyStem+BMP4-induced SK11 cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
     
     Ovary (Reproductive System)
             Mural Granulosa Cells Antral Follicle
    ADAMTS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643357
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAMTS1: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADAMTS1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1
    QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
    QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts11 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 81.04(n)1
    82.71(a)1
      16 (48.20 cM)5
    115041  NM_009621.41  NP_033751.31 
     857938275 
    chicken
    (Gallus gallus)
    Aves ADAMTS11 ADAM metallopeptidase with thrombospondin type 1 motif, more 74.53(n)
    78.09(a)
      418479  XM_416687.4  XP_416687.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS16
    ADAM metallopeptidase with thrombospondin type 1 m...
    73(a)
    1 ↔ 1
    3(147713996-147731364)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamts11 ADAM metallopeptidase with thrombospondin type 1 motif, more 71.35(n)
    75.84(a)
      100151734  NM_001127433.1  NP_001120905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adamts11 ADAM metallopeptidase with thrombospondin type 1 motif, more 62.3(n)
    62.1(a)
      565145  XM_688443.6  XP_693535.6 


    ENSEMBL Gene Tree for ADAMTS1 (if available)
    TreeFam Gene Tree for ADAMTS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADAMTS1 gene
    ADAMTS172  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    17 SIMAP similar genes for ADAMTS1 using alignment to 5 protein entries:     ATS1_HUMAN (see all proteins):
    DKFZp686E01144    TSHZ2    ADAMTS8    ADAMTS9    ADAMTS15    ADAMTS5
    ADAMTS4    ADAMTS20    ADAMTS13    ADAMTS18    ADAMTS6    ADAMTS12
    ADAMTS16    ADAMTS10    ADAMTS2    ADAMTS3    ADAMTS7

    Find genes that share paralogs with ADAMTS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADAMTS1 (see all 372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013164511,2
    --28208109(+) ATACC-/AGGGTT 1 -- ds50010--------
    rs347241991,2
    C--28208110(+) TACCAG/-GGTTG 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1437463191,2
    --28208192(+) TGTCCA/TTTCAC 1 -- ds50010--------
    rs1481463231,2
    --28208203(+) TTACTC/TATTCT 1 -- ds50010--------
    rs1420007111,2
    --28208213(+) TTTATG/TGCTAG 1 -- ds50010--------
    rs1461651341,2
    C--28208271(+) TGACAA/GGATAG 1 -- ds50010--------
    rs1874775441,2
    --28208301(+) AGTTGA/CAAATA 1 -- ds50010--------
    rs13734661,2
    C,H--28208405(+) TTTTAG/ACAATC 1 -- ds50017Minor allele frequency- A:0.00MN NS EA NA 600
    rs731858461,2
    --28208425(+) AAGGAC/TATAAG 1 -- ds50010--------
    rs2290411,2
    C,F,O,A,H--28208468(+) CAGCCA/C/GTCTTG 1 -- ds500124MN NS EA NA WA CSA 2539

    HapMap Linkage Disequilibrium report for ADAMTS1 (28208066 - 28217728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAMTS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470897CNV Loss18288195
    nsv834068CNV Loss17160897
    nsv3482CNV Loss18451855
    nsv528278CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTS1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605174    OMIM disorders: --

    1 disease for ADAMTS1:    
    About MalaCards
    type 2a von willebrand disease


    Find genes that share disorders with ADAMTS1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADAMTS1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 32 7 16949904 (7)
    arthritis 32 1 12755694 (1)
    osteosarcoma 13.8 1 11108265 (1)
    neurodegeneration 9.92 1 15661359 (1)
    prostate cancer 9.68 1 15599946 (1)
    cancer 4.05 4 16949904 (1), 16495931 (1), 17355265 (1), 15972109 (1)
    necrosis 0 8 14996435 (2), 19404339 (1), 15880812 (1)
    inflammation 0 3 16328961 (1), 17088949 (1)
    metastasis 0 12 16314835 (4)
    atherosclerosis 0 1 15539621 (1)

    Genetic Association Database (GAD): ADAMTS1
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS1 (6 documents)

    Export disorders for ADAMTS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADAMTS1 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with ADAMTS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 9 Vazquez F.... Iruela-Arispe M.L. (J. Biol. Chem. 1999)
    2. Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. (PubMed id 17897672)1, 2, 9 Gerhardt S....Abbott W.M. (J. Mol. Biol. 2007)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    4. Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy. (PubMed id 18174457)1, 4 Sabatine M.S....Braunwald E. (Arterioscler. Thromb. Vasc. Biol. 2008)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Differential gene expression by endothelial cells in distinct angiogenic states. (PubMed id 10785405)1, 2 Glienke J.... Thierauch K.H. (Eur. J. Biochem. 2000)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    9. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. (PubMed id 19349275)1, 9 Hatipoglu O.F....Ninomiya Y. (J. Biol. Chem. 2009)
    10. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. (PubMed id 16314835)1, 9 Liu Y.J....Yu Q. (Oncogene 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9510 HGNC: 217 AceView: ADAMTS1 Ensembl:ENSG00000154734 euGenes: HUgn9510
    ECgene: ADAMTS1 H-InvDB: ADAMTS1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1346

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADAMTS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAMTS1 gene:
    Search GeneIP for patents involving ADAMTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS1
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ADAMTS1 (ADAMTS1)   Browse Cell Culture Products  
     ELISAs for ADAMTS1 (ADAMTS1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ADAMTS1 (ADAMTS1)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ADAMTS1 (ADAMTS1)  
     OriGene Antibodies for ADAMTS1   OriGene RNAi products in human, mouse, rat for ADAMTS1  
     OriGene qPCR primer pairs and template standards for ADAMTS1   OriGene Protein Over-expression Lysate for ADAMTS1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAMTS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAMTS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAMTS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS1   OriGene Custom Protein Services for ADAMTS1  

     
     
     Block miRNA regulation of human, mouse, rat ADAMTS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAMTS1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTS1 Predesigned siRNA for gene silencing in human, mouse, rat ADAMTS1
     QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1 QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
     PCR Arrays including human, mouse, rat ADAMTS1 Search Chromatin IP Primers for ADAMTS1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1  GeneGlobe Interaction Network for ADAMTS1
     Regulatory tfbs in ADAMTS1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS1 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS1
     GenScript Custom Assay Services for ADAMTS1 GenScript Custom overexpressing Cell Line Services for ADAMTS1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ADAMTS1 

     Search Tocris compounds for ADAMTS1 (ATS1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ADAMTS1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for ADAMTS1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADAMTS1 antibodies
     ADAMTS1 proteins
     ADAMTS1 lysates
     Antibodies for ADAMTS1
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ADAMTS1
     Antibodies for ADAMTS1
     ELISAs for ADAMTS1
     CLIAs for ADAMTS1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADAMTS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS1
     SwitchGear Promoter luciferase reporter plasmids for ADAMTS1
     ThermoFisher Antibodies for ADAMTS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTS1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAMTS1
     LSBio Antibodies in human, mouse, rat for ADAMTS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ADAMTS1
      Search eBioscience for proteins for ADAMTS1
      Search eBioscience for elisas for ADAMTS1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAMTS1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4