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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS1 Gene

protein-coding   GIFtS: 68
GCID: GC21M028208

ADAM Metallopeptidase With Thrombospondin Type 1 Motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 11 2     C3-C52
METH12 3 5     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With
Thrombospondin Type 1 Motif, 11 2
     EC 3.4.24.-3
Human Metalloproteinase With Thrombospondin Type 1 Motifs2 11     KIAA13463
ADAM-TS12 3     EC 3.4.248
ADAMTS-12 3     EC 3.4.24.148
METH-12 3     EC 3.4.24.828
ADAM-TS 12 3     

External Ids:    HGNC: 2171   Entrez Gene: 95102   Ensembl: ENSG000001547347   OMIM: 6051745   UniProtKB: Q9UHI83   

Export aliases for ADAMTS1 gene to outside databases

Previous GC identifers: GC21M024787 GC21M027130 GC21M013613


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS1 Gene:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members
of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein
encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic
activity. The expression of this gene may be associated with various inflammatory processes as well as
development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ
morphology and function. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTS1 Gene: 
ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) is a protein-coding gene. Diseases associated with ADAMTS1 include type 2a von willebrand disease, and hypertrophic scars, and among its related super-pathways are Cell adhesion ECM remodeling. GO annotations related to this gene include metallopeptidase activity and heparin binding. An important paralog of this gene is ADAMTS17.

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory
processes as well as development of cancer cachexia. May play a critical role in follicular rupture

Gene Wiki entry for ADAMTS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS1 gene promoter:
         Sp1   ATF-2   POU6F1 (c2)   Nkx2-5   HNF-3beta   RORalpha2   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTS1 promoter sequence

   Search SABiosciences Chromatin IP Primers for ADAMTS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q21.3
ADAMTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M028208:   GeneLoc Nature:405,311-319
Start:
28,208,606 bp from pter       13,786,471 bp from centromere
End:
28,217,728 bp from pter 13,795,380 bp from centromere
Size:
9,123 bases 8,910 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF170084
genomic clones: KB2043D3 KB126A3


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor  
Size: 967 amino acids; 105358 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=AAD48080.1; Type=Erroneous initiation; Sequence=BAA92584.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for ADAMTS1:
2JIH (3D)        2V4B (3D)        3Q2G (3D)        3Q2H (3D)    
Secondary accessions: D3DSD5 Q9NSJ8 Q9P2K0 Q9UH83 Q9UP80

Explore the universe of human proteins at neXtProt for ADAMTS1: NX_Q9UHI8

Explore proteomics data for ADAMTS1 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within
    the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHI8

  • 4/14 DME Specific Peptides for ADAMTS1 (Q9UHI8) (see all 14)
     SCSVIED  PWGDCSR  KHPSIRN  VIEDDGL 

    ADAMTS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMTS1 Protein Expression
    REFSEQ proteins: NP_008919.3  
    ENSEMBL proteins: 
     ENSP00000284984   ENSP00000429557   ENSP00000403404   ENSP00000431065  

    Human Recombinant Protein Products for ADAMTS1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMTS1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----
    GO:0031410cytoplasmic vesicle IEA--

    ADAMTS1 for ontologies           About GeneDecksing



    ADAMTS1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ADAMTS1 

    Assay Products for ADAMTS1: 
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    Cloud-Clone Corp. ELISAs for ADAMTS1 
    Cloud-Clone Corp. CLIAs for ADAMTS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAMTS: ADAM metallopeptidases with thrombospondin type 1 motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAMTS1 
    ADAMTS family

    5/8 InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR006586 ADAM_Cys-rich
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UHI8

    ProtoNet protein and cluster: Q9UHI8

    5 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains


    ADAMTS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATS1_HUMAN, Q9UHI8
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
    angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory
    processes as well as development of cancer cachexia. May play a critical role in follicular rupture
    Catalytic activity: Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment
    domain

         Genatlas biochemistry entry for ADAMTS1:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular
    matrix protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth
    factor induced angiogenesis

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
    GO:0008237metallopeptidase activity TAS10438512
    GO:0008270zinc ion binding IEA--
         
    ADAMTS1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADAMTS1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adamts1):
     adipose tissue  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  renal/urinary system  reproductive system 

    ADAMTS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADAMTS1: Adamts1tm1Mapr Adamts1tm1Hku Adamts1tm1Mlia

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAMTS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAMTS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAMTS1 

    miRNA
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    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-let-7d hsa-miR-548k hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidADAMTS1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAMTS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    2Endochondral Ossification
    Endochondral Ossification
    3Angiogenesis
    Angiogenesis
    4Adhesion
    Adhesion
    5Notch Signaling Pathway
    Notch Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADAMTS1
        Metalloproteases in connective tissue degradation


    2 Cell Signaling Technology (CST) Pathways for ADAMTS1
        Angiogenesis
    Adhesion

    1 BioSystems Pathway for ADAMTS1
        Endochondral Ossification

    1 Sino Biological Pathway for ADAMTS1 
        Notch Signaling Pathway



    ADAMTS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/19 Interacting proteins for ADAMTS1 (Q9UHI83 ENSP000002849844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001822kidney development IEA--
    GO:0006508proteolysis IEA--
    GO:0007229integrin-mediated signaling pathway TAS8995297
    GO:0008285negative regulation of cell proliferation TAS10438512

    ADAMTS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAMTS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ADAMTS1

    Browse Tocris compounds for ADAMTS1 (ATS1)

    2 HMDB Compounds for ADAMTS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin sulfateChondritinsulfate (see all 12)9007-28-7--

    6 Novoseek inferred chemical compound relationships for ADAMTS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 41.3 3 15599946 (3)
    forskolin 11.6 1 11108265 (1)
    thymidine 0 1 16936124 (1)
    progesterone 0 3 14664708 (2)
    serine 0 1 15972109 (1)
    heparin 0 2 9593739 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS1 / ATS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTS1 gene: 
    NM_006988.3  

    Unigene Cluster for ADAMTS1:

    ADAM metallopeptidase with thrombospondin type 1 motif, 1
    Hs.643357  [show with all ESTs]
    Unigene Representative Sequence: NM_006988
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464589 ENST00000284984(uc002ymf.3) ENST00000492656 ENST00000517777
    ENST00000451462 ENST00000517452

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    Additional mRNA sequence: 

    AB037767.1 AF060152.1 AF170084.1 AF207664.1 AK129873.1 AK314475.1 AL162080.1 AL355723.1 
    AL355724.1 BC036515.2 BX647388.1 DQ108407.1 

    8 DOTS entries:

    DT.318280  DT.101981770  DT.95189320  DT.100791687  DT.100791688  DT.97846508  DT.121133409  DT.80100485 

    24/343 AceView cDNA sequences (see all 343):

    AI144408 BU752212 BM700592 AA031616 AA345812 CA455043 BM994920 T40492 
    AI692832 AI689182 BQ879906 AK129873 AL553171 BF589805 AA918632 BI962765 
    BG569837 BX406349 CD623532 AI128171 BQ723043 BM668580 Z41664 BI789256 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                       
    SP2:                                                            


    ECgene alternative splicing isoforms for ADAMTS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS1 expression in normal human tissues (normalized intensities)      ADAMTS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTTATAA
    ADAMTS1 Expression
    About this image


    ADAMTS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             Human Bladder Smooth Muscle Cells (HBdSMC)   
             visceral organ   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Rib
             Human fetal bone marrow-derived mesenchymal stromal cells
             HyStem+BMP4-induced SK11 cells
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See ADAMTS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS1

    SOURCE GeneReport for Unigene cluster: Hs.643357
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADAMTS1: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMTS1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamts11 , 5 a disintegrin-like and metallopeptidase (reprolysin more1, 5 81.7(n)1
    83.02(a)1
      16 (48.20 cM)5
    115041  NM_009621.41  NP_033751.31 
     857938275 
    chicken
    (Gallus gallus)
    Aves ADAMTS11 ADAM metallopeptidase with thrombospondin type 1 motif, more 74.31(n)
    78.19(a)
      418479  XM_416687.3  XP_416687.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTS16
    ADAM metallopeptidase with thrombospondin type 1 m...
    73(a)
    1 ↔ 1
    3(147713996-147731364)
    zebrafish
    (Danio rerio)
    Actinopterygii adamts11 ADAM metallopeptidase with thrombospondin type 1 motif, more 61.58(n)
    60.83(a)
      565145  XM_688443.5  XP_693535.5 


    ENSEMBL Gene Tree for ADAMTS1 (if available)
    TreeFam Gene Tree for ADAMTS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS1 gene
    ADAMTS172  ADAMTS182  ADAMTS192  ADAMTS62  ADAMTS142  ADAMTS22  ADAMTS202  ADAMTS52  
    ADAMTS152  ADAMTS42  ADAMTS92  ADAMTS82  ADAMTS162  ADAMTS32  ADAMTS102  
    17 SIMAP similar genes for ADAMTS1 using alignment to 5 protein entries:     ATS1_HUMAN (see all proteins):
    DKFZp686E01144    TSHZ2    ADAMTS8    ADAMTS15    ADAMTS9    ADAMTS5
    ADAMTS4    ADAMTS20    ADAMTS13    ADAMTS18    ADAMTS6    ADAMTS12
    ADAMTS16    ADAMTS10    ADAMTS2    ADAMTS3    ADAMTS7

    ADAMTS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 SNPs in ADAMTS1 are shown (see all 372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013164511,2
    --28208109(+) ATACC-/AGGGTT 1 -- ds50010--------
    rs347241991,2
    C--28208110(+) TACCAG/-GGTTG 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1437463191,2
    --28208192(+) TGTCCA/TTTCAC 1 -- ds50010--------
    rs1481463231,2
    --28208203(+) TTACTC/TATTCT 1 -- ds50010--------
    rs1420007111,2
    --28208213(+) TTTATG/TGCTAG 1 -- ds50010--------
    rs1461651341,2
    C--28208271(+) TGACAA/GGATAG 1 -- ds50010--------
    rs1874775441,2
    --28208301(+) AGTTGA/CAAATA 1 -- ds50010--------
    rs13734661,2
    C,H--28208405(+) TTTTAG/ACAATC 1 -- ds50017Minor allele frequency- A:0.00MN NS EA NA 600
    rs731858461,2
    --28208425(+) AAGGAC/TATAAG 1 -- ds50010--------
    rs2290411,2
    C,F,O,A,H--28208468(+) CAGCCA/C/GTCTTG 1 -- ds500124MN NS EA NA WA CSA 2539

    HapMap Linkage Disequilibrium report for ADAMTS1 (28208606 - 28217728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAMTS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470897CNV Loss18288195
    nsv834068CNV Loss17160897
    nsv3482CNV Loss18451855
    nsv528278CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605174    OMIM disorders: --

    20/28 diseases for ADAMTS1 (see all 28):    About MalaCards
    type 2a von willebrand disease    hypertrophic scars    cerebral artery occlusion    ureteral obstruction
    thoracic aortic aneurysm    non-small cell lung carcinoma    chondrosarcoma    von willebrand's disease
    pick's disease    aortic aneurysm    osteosarcoma    acute myocardial infarction
    atherosclerosis    coronary heart disease    fibrosarcoma    myocardial infarction
    down syndrome    hypoxia    renal cell carcinoma    cerebritis


    ADAMTS1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for ADAMTS1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 32 7 16949904 (7)
    arthritis 32 1 12755694 (1)
    osteosarcoma 13.8 1 11108265 (1)
    neurodegeneration 9.92 1 15661359 (1)
    prostate cancer 9.68 1 15599946 (1)
    cancer 4.05 4 16949904 (1), 16495931 (1), 17355265 (1), 15972109 (1)
    necrosis 0 8 14996435 (2), 19404339 (1), 15880812 (1)
    inflammation 0 3 16328961 (1), 17088949 (1)
    metastasis 0 12 16314835 (4)
    atherosclerosis 0 1 15539621 (1)

    Genetic Association Database (GAD): ADAMTS1
    Human Genome Epidemiology (HuGE) Navigator: ADAMTS1 (6 documents)

    Export disorders for ADAMTS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS1 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with ADAMTS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 9 Vazquez F.... Iruela-Arispe M.L. (1999)
    2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    3. Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy. (PubMed id 18174457)1, 4 Sabatine M.S....Braunwald E. (2008)
    4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. Differential gene expression by endothelial cells in distinct angiogenic states. (PubMed id 10785405)1, 2 Glienke J.... Thierauch K.H. (2000)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    8. ADAMTS1 is a unique hypoxic early response gene expre ssed by endothelial cells. (PubMed id 19349275)1, 9 Hatipoglu O.F....Ninomiya Y. (2009)
    9. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. (PubMed id 16314835)1, 9 Liu Y.J....Yu Q. (2006)
    10. ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta. (PubMed id 14760803)1, 9 Wachsmuth L....Aigner T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9510 HGNC: 217 AceView: ADAMTS1 Ensembl:ENSG00000154734 euGenes: HUgn9510
    ECgene: ADAMTS1 H-InvDB: ADAMTS1

    (According to HUGE)
    About This Section
    HUGE: KIAA1346

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTS1 gene:
    Search GeneIP for patents involving ADAMTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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