Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTS1 Gene

protein-coding   GIFtS: 65
GCID: GC21M028208

ADAM metallopeptidase with thrombospondin type 1 motif,...

(Previous names: a disintegrin-like and metalloprotease (reprolysin type)...)
 Explore 30 diseases affiliated with
ADAMTS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMTS1    

Aliases
for ADAMTS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 11 2     METH-12 3
METH11 2 3 5     ADAM-TS 12 3
C3-C51 2     A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin
Type 1 Motif, 11 2
     EC 3.4.24.-3
KIAA13461 3     EC 3.4.248
Human Metalloproteinase With Thrombospondin Type 1 Motifs2 11     EC 3.4.24.148
ADAM-TS12 3     EC 3.4.24.828
ADAMTS-12 3     

External Ids:    HGNC: 2171   Entrez Gene: 95102   Ensembl: ENSG000001547347   OMIM: 6051745   UniProtKB: Q9UHI83   

Export aliases for ADAMTS1 gene to outside databases

Previous GC identifers: GC21M024787 GC21M027130 GC21M013613


Summaries
for ADAMTS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTS1:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded
by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The
expression of this gene may be associated with various inflammatory processes as well as development of cancer
cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as
well as development of cancer cachexia. May play a critical role in follicular rupture

Gene Wiki entry for ADAMTS1


Genomic Views
for ADAMTS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS1 gene promoter:
         Sp1   ATF-2   POU6F1 (c2)   Nkx2-5   HNF-3beta   RORalpha2   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTS1 promoter sequence

   Search SABiosciences Chromatin IP Primers for ADAMTS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q21.3
ADAMTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M028208:   GeneLoc Nature:405,311-319
Start:
 28,208,606 bp from pter       13,786,471 bp from centromere
End:
 28,217,728 bp from pter 13,795,380 bp from centromere
Size:
 9,123 bases 8,910 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF170084
genomic clones: KB2043D3 KB126A3


Proteins
for ADAMTS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor  
Size: 967 amino acids; 105358 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=AAD48080.1; Type=Erroneous initiation; Sequence=BAA92584.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for ADAMTS1:
2JIH (3D)        2V4B (3D)        3Q2G (3D)        3Q2H (3D)    
Secondary accessions: D3DSD5 Q9NSJ8 Q9P2K0 Q9UH83 Q9UP80

Explore the universe of human proteins at neXtProt for ADAMTS1: NX_Q9UHI8

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence
    • C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the
    repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose
    residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members.
    Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence
    W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHI8

    • 4/14 DME Specific Peptides for ADAMTS1 (Q9UHI8) (see all 14)
     SCSVIED  PWGDCSR  KHPSIRN  VIEDDGL 

    ADAMTS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008919.3  
    ENSEMBL proteins: 
     ENSP00000284984   ENSP00000429557   ENSP00000403404   ENSP00000431065  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADAMTS1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ADAMTS1
    OriGene Custom Protein Services for ADAMTS1 
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS1
    Novus Biologicals ADAMTS1 Proteins
    Novus Biologicals ADAMTS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAMTS1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----
    GO:0031410cytoplasmic vesicle IEA--


    ADAMTS1 for ontologies           About GeneDecksing



    ADAMTS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS1
    R&D Systems Antibodies for ADAMTS1
    OriGene Antibodies: ADAMTS1
    OriGene Custom Antibody Services for ADAMTS1 
    GenScript Custom Superior Antibodies Services for ADAMTS1
    Novus Biologicals ADAMTS1 Antibodies
    Search for Antibodies for ADAMTS1 at Abcam  
    Uscn Antibodies for ADAMTS1
    ThermoFisher Antibodies for ADAMTS1

    Assay Products for ADAMTS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for ADAMTS1         (see all)
    GenScript Custom Assay Services for ADAMTS1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAMTS1

    Protein Domains /
    Families
    for ADAMTS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTS1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR024079 MetalloPept_cat_dom
     IPR010294 ADAM_spacer1
     IPR006586 ADAM_Cys-rich
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UHI8

    ProtoNet protein and cluster: Q9UHI8

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains


    Function
    for ADAMTS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has
    angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as
    well as development of cancer cachexia. May play a critical role in follicular rupture
    Catalytic activity: Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment domain

         Genatlas biochemistry entry for ADAMTS1:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular matrix
    protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth factor induced
    angiogenesis

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.142 EC 3.4.24.822 EC 3.4.242

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ADAMTS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS1
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS1 (see all 57):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-let-7d hsa-miR-548k hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS1 (see all 7)
    OriGene shRNA RFP: ADAMTS1
    OriGene siRNA: ADAMTS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADAMTS1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988)
    Sino Biological Human cDNA Clone for ADAMTS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ADAMTS1
    Search LifeMap BioReagents cell lines for ADAMTS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
    GO:0008237metallopeptidase activity TAS10438512
    GO:0008270zinc ion binding IEA--


    ADAMTS1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ADAMTS1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for ADAMTS1: Adamts1tm1Mapr Adamts1tm1Hku Adamts1tm1Mlia
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adamts1):
     adipose tissue  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  renal/urinary system  reproductive system 

    ADAMTS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAMTS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endochondral Ossification
    		Endochondral Ossification1.00
    2Cell adhesion_ECM remodeling
    		Metalloproteases in connective tissue degradation0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADAMTS1
        Metalloproteases in connective tissue degradation


    1 BioSystems Pathway for ADAMTS1 
        Endochondral Ossification



    ADAMTS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/19 Interacting proteins for ADAMTS1 (Q9UHI83 ENSP000002849844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001822kidney development IEA--
    GO:0006508proteolysis IEA--
    GO:0007229integrin-mediated signaling pathway TAS8995297
    GO:0008285negative regulation of cell proliferation TAS10438512


    ADAMTS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAMTS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ADAMTS1

    Browse Tocris compounds for ADAMTS1

    2 HMDB Compounds for ADAMTS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin sulfateChondritinsulfate (see all 12)9007-28-7--
    6 Novoseek chemical compound relationships for ADAMTS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 41.3 3 15599946 (3)
    forskolin 11.6 1 11108265 (1)
    thymidine 0 1 16936124 (1)
    progesterone 0 3 14664708 (2)
    serine 0 1 15972109 (1)
    heparin 0 2 9593739 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAMTS1 / ATS1 

    Transcripts
    for ADAMTS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTS1 gene: 
    NM_006988.3  

    Unigene Cluster for ADAMTS1:

    ADAM metallopeptidase with thrombospondin type 1 motif, 1
    Hs.643357  [show with all ESTs]
    Unigene Representative Sequence: NM_006988
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464589 ENST00000284984(uc002ymf.3) ENST00000492656 ENST00000517777
    ENST00000451462 ENST00000517452

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ADAMTS1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTS1
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTS1 (see all 57):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-let-7d hsa-miR-548k hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTS1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS1 (see all 7)
    OriGene shRNA RFP: ADAMTS1
    OriGene siRNA: ADAMTS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1

    Additional cDNA sequence: 

    AB037767.1 AF060152.1 AF170084.1 AF207664.1 AK129873.1 AK314475.1 AL162080.1 AL355723.1 
    AL355724.1 BC036515.2 BX647388.1 DQ108407.1 

    8 DOTS entries:

    DT.318280  DT.101981770  DT.95189320  DT.100791687  DT.97846508  DT.100791688  DT.121133409  DT.80100485 

    24/343 AceView cDNA sequences (see all 343):

    AW470024 BQ029234 AI199506 BU737811 AI040586 CA448387 AW474740 BQ771738 
    AI128171 AI985641 BQ018495 AL162080 AW050517 AI089584 BU740006 BQ893675 
    BM930186 BQ000980 NM_006988 CA448974 CA447318 AL553171 Z41664 CA415507 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                       
    SP2:                                                            


    ECgene alternative splicing isoforms for ADAMTS1

    Expression
    for ADAMTS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTTTATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMural Granulosa CellsOvary
    LungRespiratory BronchiolesBasal CellsLung
    BoneThoracic RibBone
    LimbLimb BudLimb
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See ADAMTS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTS1

    SOURCE GeneReport for Unigene cluster: Hs.643357
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADAMTS1: 
              Notch Signaling Targets in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1

    Orthologs
    for ADAMTS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTS1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTS11 ADAM metallopeptidase with thrombospondin type 1 motif, more 74.31(n)
    78.19(a)    		   418479  XM_416687.3  XP_416687.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAMTS16
    		 --
    		 71(a)
    		 1 ↔ 1
    		 3(147713966-147729931)
    zebrafish
    (Danio rerio)    		 Actinopterygii adamts11 ADAM metallopeptidase with thrombospondin type 1 motif, more 61.58(n)
    60.83(a)    		   565145  XM_688443.5  XP_693535.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG148696
    		 --
    		 16(a)
    		 1 → many
    		 3R(11267965-11301915)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-176
    gon-16
    		 ADAM family mig-17
    A disintegrin and metalloproteinase with thrombosp...
    		 17(a)
    15(a)
    		 possible ortholog
    1 ↔ many
    		 V(11446634-11449228)
    IV(9935046-9945754)


    ENSEMBL Gene Tree for ADAMTS1 (if available)
    TreeFam Gene Tree for ADAMTS1 (if available) 

    Paralogs
    for ADAMTS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTS1 gene
    ADAMTS172  ADAMTS182  ADAMTS62  ADAMTS122  ADAMTS202  ADAMTS52  ADAMTS42  ADAMTS92  
    ADAMTS162  ADAMTS102  ADAMTS72  ADAMTS192  ADAMTS142  ADAMTS22  ADAMTS152  ADAMTS82  
    ADAMTS32  
    17 SIMAP similar genes for ADAMTS1 using alignment to 5 protein entries:     ATS1_HUMAN (see all proteins):
    DKFZp686E01144    TSHZ2    ADAMTS8    ADAMTS15    ADAMTS9    ADAMTS5
    ADAMTS4    ADAMTS20    ADAMTS13    ADAMTS18    ADAMTS6    ADAMTS12
    ADAMTS16    ADAMTS10    ADAMTS2    ADAMTS3    ADAMTS7

    ADAMTS1 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/283 NCBI SNPs in ADAMTS1 are shown (see all 283)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2013164511,2
    		--28208109(+) ATACC-/AGGGTT 1 -- ds50010--------
    rs347241991,2
    		C,--28208110(+) TACCAG/-GGTTG 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1437463191,2
    		--28208192(+) TGTCCA/TTTCAC 1 -- ds50010--------
    rs1481463231,2
    		--28208203(+) TTACTC/TATTCT 1 -- ds50010--------
    rs1420007111,2
    		--28208213(+) TTTATG/TGCTAG 1 -- ds50010--------
    rs1461651341,2
    		--28208271(+) TGACAA/GGATAG 1 -- ds50010--------
    rs1874775441,2
    		--28208301(+) AGTTGA/CAAATA 1 -- ds50010--------
    rs13734661,2
    		C,H--28208405(+) TTTTAG/ACAATC 1 -- ds50017Minor allele frequency- A:0.00MN NS EA NA 600
    rs731858461,2
    		--28208425(+) AAGGAC/TATAAG 1 -- ds50010--------
    rs2290411,2
    		C,F,O,A,H,--28208468(+) CAGCCA/C/GTCTTG 1 -- ds500124MN NS EA NA WA CSA 2539

    HapMap Linkage Disequilibrium report for ADAMTS1 (28208606 - 28217728 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ADAMTS1
         1 CNV: 35959

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTS1

    Disorders / Diseases
    for ADAMTS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTS1 for disorders           About GeneDecksing

    OMIM gene information: 605174    OMIM disorders: --

    20/30 diseases for ADAMTS1 (see all 30):    About MalaCards
    non-small cell lung carcinoma    thoracic aortic aneurysm    aortic aneurysm    cerebral artery occlusion
    ureteral obstruction    myocardial infarction    acute myocardial infarction    coronary heart disease
    pick's disease    chondrosarcoma    renal cell carcinoma    neurodegeneration
    down syndrome    multiple sclerosis    lung carcinoma    osteosarcoma
    prostate cancer    fibrosarcoma    atherosclerosis    cerebritis

    10/11 Novoseek disease relationships for ADAMTS1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 32 7 16949904 (7)
    arthritis 32 1 12755694 (1)
    osteosarcoma 13.8 1 11108265 (1)
    neurodegeneration 9.92 1 15661359 (1)
    prostate cancer 9.68 1 15599946 (1)
    cancer 4.05 4 16949904 (1), 16495931 (1), 17355265 (1), 15972109 (1)
    necrosis 0 8 14996435 (2), 19404339 (1), 15880812 (1)
    inflammation 0 3 16328961 (1), 17088949 (1)
    metastasis 0 12 16314835 (4)
    atherosclerosis 0 1 15539621 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS1 (6 documents)

    Export disorders for ADAMTS1 gene to outside databases

    Publications
    for ADAMTS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTS1 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with ADAMTS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 9 Vazquez F.... Iruela-Arispe M.L. (1999)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    3. Differential gene expression by endothelial cells in distinct angiogenic states. (PubMed id 10785405)1, 2 Glienke J.... Thierauch K.H. (2000)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    5. ADAMTS1 is a unique hypoxic early response gene expre ssed by endothelial cells. (PubMed id 19349275)1, 9 Hatipoglu O.F....Ninomiya Y. (2009)
    6. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. (PubMed id 16314835)1, 9 Liu Y.J....Yu Q. (2006)
    7. ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta. (PubMed id 14760803)1, 9 Wachsmuth L....Aigner T. (2004)
    8. ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix. (PubMed id 10373500)1, 9 Kuno K....Matsushima K. (1999)
    9. Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities. (PubMed id 16328961)1, 9 Lind T....McKie N. (2006)
    10. ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing. (PubMed id 17560840)1, 9 Rehn A.P....Lind T. (2007)

    External Searches for ADAMTS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAMTS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9510 HGNC: 217 AceView: ADAMTS1 Ensembl:ENSG00000154734 euGenes: HUgn9510
    ECgene: ADAMTS1 H-InvDB: ADAMTS1

    Other Databases showing ADAMTS1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1346

    Specialized Databases showing ADAMTS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAMTS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAMTS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTS1 gene:
    Search GeneIP for patents involving ADAMTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ADAMTS1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAMTS1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ADAMTS1 (ADAMTS1)   Browse Cell Culture Products  
     ELISAs for ADAMTS1 (ADAMTS1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for ADAMTS1 (ADAMTS1)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for ADAMTS1 (ADAMTS1)  
     OriGene Antibodies for ADAMTS1   OriGene shRNA RFP for ADAMTS1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTS1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTS1  
     OriGene Protein Over-expression Lysate for ADAMTS1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ADAMTS1   OriGene 3'-UTR Clone for ADAMTS1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTS1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTS1   OriGene Custom Protein Services for ADAMTS1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTS1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTS1
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTS1 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTS1
     GenScript Custom Assay Services for ADAMTS1 GenScript Custom Superior Antibodies Services for ADAMTS1
     GenScript Custom overexpressing Cell Line Services for ADAMTS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAMTS1 promoter
     Search Chromatin IP Primers for ADAMTS1
     RT2 qPCR Primer Assay in human, mouse, rat ADAMTS1
     GNC Network for ADAMTS1
     SABiosciences PCR Arrays including human, mouse, rat ADAMTS1
     Search Tocris compounds for ADAMTS1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for ADAMTS1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for ADAMTS1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAMTS1 antibodies
     ADAMTS1 proteins
     ADAMTS1 lysates
     Search for Antibodies for ADAMTS1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ADAMTS1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ADAMTS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTS1
     SwitchGear Promoter luciferase reporter plasmids for ADAMTS1
     ThermoFisher Antibodies for ADAMTS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTS1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ADAMTS1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4