ADAMTS1 Gene
protein-coding GIFtS : 65
GCID: GC21 M028208
ADAM metallopeptidase with thrombospondin type 1 motif,... (Previous names: a disintegrin-like and metalloprotease (reprolysin type)... )
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Aliasesfor ADAMTS1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb , and/or 11 Nature :405,311-319 and CroW21)About This Section Aliases ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 1 1 2 METH-12 3 METH11 2 3 5 ADAM-TS 12 3 C3-C51 2 A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12 A Disintegrin-Like And Metalloprotease (Reprolysin Type) With ThrombospondinType 1 Motif, 11 2 EC 3.4.24.-3 KIAA13461 3 EC 3.4.248 Human Metalloproteinase With Thrombospondin Type 1 Motifs2 11 EC 3.4.24.148 ADAM-TS12 3 EC 3.4.24.828 ADAMTS-12 3
Export aliases for ADAMTS1 gene to outside databases Previous GC identifers: GC21M024787 GC21M027130 GC21M013613
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Summariesfor ADAMTS1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ADAMTS1 : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 Function : Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Hasangiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture Gene Wiki entry for ADAMTS1
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Genomic Viewsfor ADAMTS1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
GC21M028208:
GeneLoc
Nature :405,311-319
Start:
28,208,606 bp from pter
13,786,471 bp from centromere
End:
28,217,728 bp from pter
13,795,380 bp from centromere
Size:
9,123 bases
8,910 bases
Orientation:
minus strand
minus strand
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Proteinsfor ADAMTS1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 (See
protein sequence )Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor Size : 967 amino acids; 105358 Da
Cofactor : Binds 1 zinc ion per subunit (By similarity)
Subcellular location : Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution : Sequence=AAD48080.1; Type=Erroneous initiation; Sequence=BAA92584.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for ADAMTS1 :2JIH (3D)
  2V4B (3D)
  3Q2G (3D)
  3Q2H (3D)
 
Secondary accessions : D3DSD5 Q9NSJ8 Q9P2K0 Q9UH83 Q9UP80Explore the universe of human proteins at neXtProt for ADAMTS1: NX_Q9UHI8 Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UHI8 4/14 DME Specific Peptides for ADAMTS1 (Q9UHI8 ) (see all 14 )ADAMTS1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_008919.3 ENSEMBL proteins: ENSP00000284984 ENSP00000429557 ENSP00000403404 ENSP00000431065 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
ADAMTS1 for ontologies About GeneDecksing ADAMTS1 Antibody Products: Assay Products for ADAMTS1:
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Protein
Domains / Familiesfor ADAMTS1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ADAMTS1 for domains About GeneDecksing 5/8 InterPro domains/families (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q9UHI8 ProtoNet protein and cluster: Q9UHI8
5 Blocks protein families : IPB000884 Thrombospondin IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB008085 Thrombospondin type 1 repeat signature IPB010294 ADAM-TS Spacer 1 UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 Domain : The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellularmatrix Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 peptidase M12B domainSimilarity : Contains 3 TSP type-1 domains
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Functionfor ADAMTS1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 Function : Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Hasangiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture Catalytic activity : Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment domain
Genatlas biochemistry entry for ADAMTS1 : a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular matrix protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth factor induced angiogenesis Enzyme Numbers (IUBMB): EC 3.4.24.- 1 EC 3.4.24.14 2 EC 3.4.24.82 2 EC 3.4.24 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988 ) Sino Biological Human cDNA Clone for ADAMTS1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAMTS1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
ADAMTS1 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for ADAMTS1 :Animal Models: Mouse knock-outs for ADAMTS1: Adamts1 tm1Mapr Adamts1 tm1Hku Adamts1 tm1Mlia 8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Adamts1) :
ADAMTS1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ADAMTS1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Endochondral Ossification 2 Cell adhesion_ECM remodeling
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for ADAMTS1 1 BioSystems Pathway for ADAMTS1
ADAMTS1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAMTS1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/19 Interacting proteins for ADAMTS1 (Q9UHI8 3 ENSP00000284984 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 19 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
ADAMTS1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ADAMTS1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ADAMTS1 for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for ADAMTS1
Browse Tocris compounds for ADAMTS1 2 HMDB Compounds for ADAMTS1 About this table 6 Novoseek chemical compound relationships for ADAMTS1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1
41.3
3
15599946 (3)
forskolin
11.6
1
11108265 (1)
thymidine
0
1
16936124 (1)
progesterone
0
3
14664708 (2)
serine
0
1
15972109 (1)
heparin
0
2
9593739 (1)
Search CenterWatch for drugs/clinical trials and news about ADAMTS1 / ATS1
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Transcriptsfor ADAMTS1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ADAMTS1 gene: NM_006988.3 Unigene Cluster for ADAMTS1:
ADAM metallopeptidase with thrombospondin type 1 motif, 1 Hs.643357 [show with all ESTs ] Unigene Representative Sequence: NM_006988 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000464589 ENST00000284984 (uc002ymf.3 ) ENST00000492656 ENST00000517777 ENST00000451462 ENST00000517452 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ADAMTS1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAMTS1 (NM_006988 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAMTS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAMTS1
Additional cDNA sequence: AB037767.1 AF060152.1 AF170084.1 AF207664.1 AK129873.1 AK314475.1 AL162080.1 AL355723.1 AL355724.1 BC036515.2 BX647388.1 DQ108407.1
8 DOTS entries : DT.318280 DT.101981770
DT.95189320 DT.100791687 DT.97846508 DT.100791688 DT.121133409 DT.80100485 24/343 AceView cDNA sequences (see all 343 ):
AW470024 BQ029234 AI199506 BU737811 AI040586 CA448387 AW474740 BQ771738 AI128171 AI985641 BQ018495 AL162080 AW050517 AI089584 BU740006 BQ893675 BM930186 BQ000980 NM_006988 CA448974 CA447318 AL553171 Z41664 CA415507 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 SP1 :       -               SP2 :                    
ECgene alternative splicing isoforms for ADAMTS1
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Expression for ADAMTS1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ADAMTS1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACTTTATAA
About this image ADAMTS1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ADAMTS1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ADAMTS1 SOURCE GeneReport for Unigene cluster: Hs.643357 SABiosciences Expression via Pathway-Focused PCR Arrays including ADAMTS1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ADAMTS1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ADAMTS1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ADAMTS1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ADAMTS1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTS1
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Orthologsfor ADAMTS1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ADAMTS1 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ADAMTS11
ADAM metallopeptidase with thrombospondin type 1 motif, more
74.31(n) 78.19(a)
 
418479 XM_416687.3 XP_416687.3
lizard (Anolis carolinensis)
Reptilia
ADAMTS16
--
71(a)
1 ↔ 1
3(147713966-147729931)
zebrafish (Danio rerio)
Actinopterygii
adamts11
ADAM metallopeptidase with thrombospondin type 1 motif, more
61.58(n) 60.83(a)
 
565145 XM_688443.5 XP_693535.5
fruit fly (Drosophila melanogaster)
Insecta
CG148696
--
16(a)
1 → many
3R(11267965-11301915)
worm (Caenorhabditis elegans)
Secernentea
mig-176 gon-16
ADAM family mig-17A disintegrin and metalloproteinase with thrombosp...
17(a) 15(a)
possible ortholog1 ↔ many
V(11446634-11449228) IV(9935046-9945754)
ENSEMBL Gene Tree for ADAMTS1 (if available)TreeFam Gene Tree for ADAMTS1 (if available)
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Paralogsfor ADAMTS1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ADAMTS1 gene ADAMTS17 2 ADAMTS18 2 ADAMTS6 2 ADAMTS12 2 ADAMTS20 2 ADAMTS5 2 ADAMTS4 2 ADAMTS9 2 ADAMTS16 2 ADAMTS10 2 ADAMTS7 2 ADAMTS19 2 ADAMTS14 2 ADAMTS2 2 ADAMTS15 2 ADAMTS8 2 ADAMTS3 2 17 SIMAP similar genes for ADAMTS1 using alignment to 5 protein entries: ATS1_HUMAN (see all proteins ):DKFZp686E01144 TSHZ2 ADAMTS8 ADAMTS15 ADAMTS9 ADAMTS5 ADAMTS4 ADAMTS20 ADAMTS13 ADAMTS18 ADAMTS6 ADAMTS12 ADAMTS16 ADAMTS10 ADAMTS2 ADAMTS3 ADAMTS7
ADAMTS1 for paralogs About GeneDecksing
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Genomic Variantsfor ADAMTS1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ADAMTS1 (28208606 - 28217728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ADAMTS1 1 CNV : 35959
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ADAMTS1
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Disorders
/ Diseasesfor ADAMTS1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ADAMTS1 for disorders About GeneDecksing
OMIM gene information: 605174
OMIM disorders : --20/30 diseases for ADAMTS1 (see all 30 ): About MalaCards non-small cell lung carcinoma thoracic aortic aneurysm aortic aneurysm cerebral artery occlusion ureteral obstruction myocardial infarction acute myocardial infarction coronary heart disease pick's disease chondrosarcoma renal cell carcinoma neurodegeneration down syndrome multiple sclerosis lung carcinoma osteosarcoma prostate cancer fibrosarcoma atherosclerosis cerebritis 10/11 Novoseek disease relationships for ADAMTS1 gene (see all 11 ) About this table
Human Genome Epidemiology (HuGE) Navigator: ADAMTS1 (6 documents) Export disorders for ADAMTS1 gene to outside databases
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Publicationsfor ADAMTS1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ADAMTS1 gene, integrated from 9 sources (see all 106 ): (articles sorted by number of sources associating them with ADAMTS1) Utopia : connect your pdf to the dynamic world of online information
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512) 1 , 2 , 3, 9 Vazquez F.... Iruela-Arispe M.L. (1999) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198) 1 , 2 Nagase T.... Ohara O. (2000) Differential gene expression by endothelial cells in distinct angiogenic states. (PubMed id 10785405) 1 , 2 Glienke J.... Thierauch K.H. (2000) The DNA sequence of human chromosome 21. (PubMed id 10830953) 1 , 2 Hattori M....Yaspo M.L. (2000) ADAMTS1 is a unique hypoxic early response gene expre ssed by endothelial cells. (PubMed id 19349275) 1 , 9 Hatipoglu O.F....Ninomiya Y. (2009) Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. (PubMed id 16314835) 1 , 9 Liu Y.J....Yu Q. (2006) ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta. (PubMed id 14760803) 1 , 9 Wachsmuth L....Aigner T. (2004) ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix. (PubMed id 10373500) 1 , 9 Kuno K....Matsushima K. (1999) Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities. (PubMed id 16328961) 1 , 9 Lind T....McKie N. (2006) ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing. (PubMed id 17560840) 1 , 9 Rehn A.P....Lind T. (2007)
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About This Section Patent Information for ADAMTS1 gene: Search GeneIP for patents involving ADAMTS1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ADAMTS1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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