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ADAMTS1 Gene

protein-coding   GIFtS: 66

GC21M027130
ADAM metallopeptidase with thrombospondin type 1 motif, 1
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for ADAMTS1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases
ADAM-TS1 3
ADAMTS-1 3
C3-C5 1, 2
EC 3.4.24.- 3
KIAA1346 1, 2, 3
METH-1 3
METH1 1, 2, 3, 5
Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 1 2
ADAM-TS 1 3
a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 1 1, 2
human metalloproteinase with thrombospondin type 1 motifs 2, 9
External Ids
HGNC: 2171
Entrez Gene: 95102
UniProtKB: Q9UHI83
Ensembl: ENSG000001547347
Search outside databases for aliases for ADAMTS1 gene

Previous GC identifer: GC21M024787

Summaries
for ADAMTS1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ADAMTS1:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin
motif) protein family. Members of the family share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin
type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs,
and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin
loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene
may be associated with various inflammatory processes as well as development of cancer cachexia.
This gene is likely to be necessary for normal growth, fertility, and organ morphology and
function. [provided by RefSeq]

UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By
similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated
with various inflammatory processes as well as development of cancer cachexia. May play a critical
role in follicular rupture

Gene Wiki entry for ADAMTS1

Genomic Location
for ADAMTS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q21.3
ADAMTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M027130:   GeneLoc Nature:405,311-319
Start:
 27,130,477 bp from pter       13,786,471 bp from centromere
End:
 27,139,599 bp from pter 13,795,380 bp from centromere
Size:
 9,123 bases 8,910 bases
Orientation:
 minus strand minus strand
RefSeq DNA sequence:
NC_000021.7  NT_011512.10  

Whole chromosome sequencing:
cDNA sequence: AF170084
genomic clones: KB2043D3 KB126A3

Proteins
for ADAMTS1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor  
Size: 967 amino acids; 105358 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
PDB structure from and Proteopedia :
2JIH (3D)    2V4B (3D)    
Secondary accessions: Q9NSJ8 Q9P2K0 Q9UH83 Q9UP80

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_008919.3  

    ENSEMBL proteins: 
    ENSP00000372337 ENSP00000284984 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ADAMTS1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ADAMTS1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADAMTS1)
    Human Recombinant Proteins from Abnova (ADAMTS1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005604 basement membrane IEA--
    GO:0031410 cytoplasmic vesicle IEA--
    About this table

    Antibodies for ADAMTS1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ADAMTS1
    R&D Systems Antibodies for ADAMTS1
    Antibodies from Abcam (ADAMTS1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for ADAMTS1

    Assays for ADAMTS1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ADAMTS1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro domains/families (see all 9 ):
     IPR000884 Thrombospondin_1_rpt
     IPR018358 Disintegrin_CS
     IPR006586 ADAM_Cys-rich
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B


       GeneDecks  ADAMTS1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UHI8

    ProtoNet protein and cluster: Q9UHI8

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the
    extracellular matrix
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,
    thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the
    activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 3 TSP type-1 domains

    Gene Function
    for ADAMTS1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADAMTS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006988

                  Applied Biosystems Silencer® siRNAs for ADAMTS1

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS1  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ADAMTS1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006988
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006988
                                     untagged cDNA clone in CMV expression vector: NM_006988 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006988

    UniProtKB/Swiss-Prot: ATS1_HUMAN, Q9UHI8
    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By
    similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated
    with various inflammatory processes as well as development of cancer cachexia. May play a critical
    role in follicular rupture
    Catalytic activity: Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin
    sulfate attachment domain
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Genatlas biochemistry entry for ADAMTS1:
    a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif
    1,extracellular matrix protein,inflammation-induced gene inhibiting endothelial cell
    proliferation,vascular endothelial growth factor induced angiogenesis

    8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adamts1):

    adipose tissueendocrine/exocrine glandgrowth/sizehomeostasis/metabolismlethality-postnatal
    lethality-prenatal/perinatalrenal/urinary systemreproductive system

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0005515 protein binding IEA--
    GO:0008201 heparin binding IEA--
    GO:0008233 peptidase activity IEA--
    GO:0008270 zinc ion binding IEA--
    About this table

    Pathways & Interactions
    for ADAMTS1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for ADAMTS1
     Metalloproteases in connective tissue degradation

       GeneDecks  ADAMTS1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  ADAMTS1 


    5/9 Interacting proteins for ADAMTS1 (ENSP000002849843) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACANENSP000002681343STRING (score=.901)
    VCANENSP000002650773STRING (score=.897)
    TGFB1ENSP000002219303STRING (score=.894)
    FURINENSP000002681713STRING (score=.89)
    HDAC9ENSP000002620693STRING (score=.845)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542 ovulation from ovarian follicle IEA--
    GO:0001822 kidney development IEA--
    GO:0006508 proteolysis IEA--
    GO:0007229 integrin-mediated signaling pathway TAS8995297
    GO:0008285 negative regulation of cell proliferation TAS10438512
    About this table

    Drugs & Compounds
    for ADAMTS1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADAMTS1
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADAMTS1
    4 Novoseek chemical compound relationships for ADAMTS1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 43.05 3 15599946 (3)
    forskolin 12.75 1 11108265 (1)
    thymidine 0.29 1 16936124 (1)
    progesterone 0.00 3 14664708 (2)
    About this table


    Transcripts
    for ADAMTS1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADAMTS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADAMTS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006988

                  Sigma-Aldrich siRNA and siRNA Panels for ADAMTS1  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAMTS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006988  

    REFSEQ mRNAs for ADAMTS1 gene: 

    NM_006988.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006988  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006988
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006988
                                     untagged cDNA clone in CMV expression vector: NM_006988 

    Additional cDNA sequence: 

    AB037767.1 AF060152.1 AF170084.1 AF207664.1 AK129873.1 AK314475.1 AL162080.1 AL355723.1 
    AL355724.1 BC036515.2 BX647388.1 CR599440.1 CR600774.1 DQ108407.1 

    8 DOTS entries:

    DT.318280  DT.101981770  DT.95189320  DT.100791687  DT.100791688  DT.97846508  DT.121133409  DT.80100485 

    24/343 AceView cDNA sequences (see all 343 ):

    BQ002720 AA846139 CD623532 BQ021551 AK129873 BG118486 CA415507 BX504519 
    BM994458 AA781059 BM668580 AI654583 AL553171 N40523 AA129732 BM930186 
    BQ771664 CB159467 T40309 AA373718 BM068721 Z41664 AW163724 NM_006988 

    highest scoring ESTs for ADAMTS1:

    AB037767 AF060152 AF170084 AF207664 AI148739 AW163724 BC036515 BI459665 BQ723552 BU145609 

    Unigene Cluster for ADAMTS1:

    ADAM metallopeptidase with thrombospondin type 1 motif, 1
    Hs.643357  [show with all ESTs]
    Unigene Representative Sequence: NM_006988


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                       
    SP2:                                                            

    About this scheme

    ECgene alternative splicing isoforms for ADAMTS1

    2 Ensembl transcripts including schematic representations:
    ENST00000382884  ENST00000284984  

    Expression
    for ADAMTS1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADAMTS1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTS1

    1 / 2 / 3

    6 probe-sets matching ADAMTS1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		46308_at2, 3 U95-B 1 1.00 1.00 0.95 1.33 AI810627 0.40 1.00 0.76 1
    88843_at2, 3 U95-D 1 1.00 1.00 0.99 0.68 AI148739 0.80 1.00 0.91 1

    		222162_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK023795 0.40 1.00 0.76 1

    		222486_s_at2, 3 U133-B 2 1.00 0.95 -- -- AF060152 0.80 1.00 0.91 1

    		222162_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		222486_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  ADAMTS1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TACTTTATAA

    SOURCE GeneReport for Unigene cluster: Hs.643357

    Orthologs
    for ADAMTS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ADAMTS1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 ADAMTS11   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 99.69(n)
    99.9(a)    		 473934  XM_531406.2  XP_531406.2 
    cow
    (Bos taurus)    		 ADAMTS11   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 84.03(n)
    84.34(a)    		 512171  XM_589626.3  XP_589626.2 
    rat
    (Rattus norvegicus)    		 Adamts11   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 82.29(n)
    83.12(a)    		 79252  NM_024400.1  NP_077376.1 
    mouse
    (Mus musculus)    		 Adamts11, 5 16 (53.40 cM)5
    		 a disintegrin-like and metallopeptidase (reprolysin more1, 5 81.77(n)1
    83.12(a)1    		 115041  NM_009621.31  NP_033751.21 
     AA4753565  AB0017355  (see all 19)
    chicken
    (Gallus gallus)    		 ADAMTS11   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 73.45(n)
    76.55(a)    		 418479  XM_416687.2  XP_416687.2 
    About this table        Species with no ortholog for ADAMTS1

    ENSEMBL Gene Tree for ADAMTS1

    Paralogs
    for ADAMTS1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADAMTS1 gene
    ADAMTS42  ADAMTS82  ADAMTS52  

    SNPs/Variants
    for ADAMTS1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/81 NCBI SNPs in ADAMTS1 are shown (see all 81 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs3909551,2
    		A,C,F,H,O27140328(-) TCTGGT/GGAAGA 1 -- ng3111Minor allele frequency- G:0.34EU EA WA NA 978
    rs4207421,2
    		A,C,F,H,O27139978(-) TCCAAT/CCGAAC 1 -- ng3113Minor allele frequency- C:0.48MN NA EA WA 2478
    rs2290411,2
    		A,C,F,H,O27130339(+) CAGCCG/CTCTTG 1 -- ng516Minor allele frequency- C:0.41MN EU EA WA NA 617
    rs4169051,2
    		A,C,F,H,O27139317(+) ACTAAG/AAGGAG 1 -- ut5112Minor allele frequency- A:0.34NA EU EA WA 917
    rs136151,2
    		C,F,H,O27131538(+) ATGCTA/GTATCA 1 -- ut3113Minor allele frequency- G:0.22NA MN EU EA WA 1177
    rs16635011,2
    		C,F,H,O27141178(-) GTTACC/TAAGCC 1 -- ng3123Minor allele frequency- T:0.50MN EA NA NS EU WA 1771
    rs3928401,2
    		A,C,F,H27140252(+) ACTTCT/CTACGA 1 -- ng3119Minor allele frequency- C:0.46NS MN NA EA EU WA 2492
    rs96367861,2
    		A,C,F,H27131365(+) CTCACT/CTTTCT 1 -- ut31 trp33Minor allele frequency- C:0.14EU EA 272
    rs4287851,2
    		A,C,F,H27138466(+) CTGAGG/CCCCTT 1 P/A mis1 ese38Minor allele frequency- C:0.33MN NA EU EA WA 736
    rs89921,2
    		C,F,H27130825(+) ACAAGA/GCAAGT 1 -- ut31 ese39Minor allele frequency- G:0.06MN EU EA WA 1020
    About this table

    HapMap Linkage Disequilibrium images for ADAMTS1 (up to first 250kb)

    Disorders & Mutations
    for ADAMTS1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 605174

    10/11 Novoseek disease relationships for ADAMTS1 gene (see all 11 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    arthritis 33.85 1 12755694 (1)
    chondrosarcoma 33.68 7 16949904 (7)
    osteosarcoma 15.65 1 11108265 (1)
    neurodegeneration 12.65 1 15661359 (1)
    prostate cancer 12.00 1 15599946 (1)
    cancer 2.66 4 16949904 (1), 16495931 (1), 17355265 (1), 15972109 (1)
    necrosis 1.54 8 14996435 (2), 19404339 (1), 15880812 (1)
    inflammation 0.00 3 16328961 (1), 17088949 (1)
    tumors 0.00 16 16314835 (4), 18076023 (3), 14996435 (2), 15967414 (1) (see all 7)
    metastasis 0.00 12 16314835 (4)
    About this table

    Human Genome Epidemiology Navigator: ADAMTS1 (3 documents)

    Medical News
    for ADAMTS1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ADAMTS1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/84 PubMed articles for ADAMTS1 gene (see all 84 ):

    Search for ADAMTS1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAMTS1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9510 HGNC: 217 AceView: ADAMTS1 Ensembl:ENSG00000154734 euGenes: HUgn9510
    ECgene: ADAMTS1 H-InvDB: ADAMTS1

    Other Databases showing ADAMTS1

    (According to HUGE)
    About This Section
    HUGE: KIAA1346

    Specialized Databases showing ADAMTS1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ADAMTS1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for ADAMTS1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ADAMTS1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADAMTS1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ADAMTS1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ADAMTS1 Antibodies for ADAMTS1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ADAMTS1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (ADAMTS1)
     Search for Antibodies
     Chimera RNAi (ADAMTS1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ADAMTS1)
     Antibodies (ADAMTS1)
     Search OriGene for ADAMTS1
     Search Tocris compounds for ADAMTS1




     Drugs for ADAMTS1
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ADAMTS1

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

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