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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMDEC1 Gene

protein-coding   GIFtS: 50
GCID: GC08P024297

ADAM-Like, Decysin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM-Like, Decysin 11 2     decysin2
A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-12 3     Disintegrin Protease2
ADAM-Like Protein Decysin-12 3     EC 3.4.24.-3
M12.2192     DECYSIN5
ADAM DEC12     

External Ids:    HGNC: 162991   Entrez Gene: 272992   Ensembl: ENSG000001340287   OMIM: 6063935   UniProtKB: O152043   

Export aliases for ADAMDEC1 gene to outside databases

Previous GC identifers: GC08P023974 GC08P024595 GC08P024263 GC08P022786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMDEC1 Gene:
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family.
Its expression is upregulated during dendritic cells maturation. This protein may play an important role in
dendritic cell function and their interactions with germinal center T cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMDEC1 Gene: 
ADAMDEC1 (ADAM-like, decysin 1) is a protein-coding gene. Diseases associated with ADAMDEC1 include pulmonary sarcoidosis, and venous thromboembolism. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is ADAM23.

UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
Function: May play an important role in the control of the immune response and during pregnancy (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMDEC1 gene promoter:
         TBP   Sox5   HSF1 (long)   E4BP4   FOXO3b   FOXO4   FOXO1a   HSF1short   RSRFC4   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMDEC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMDEC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMDEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p12

ADAMDEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMDEC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P024297:  view genomic region     (about GC identifiers)

Start:
24,241,798 bp from pter      End:
24,263,526 bp from pter
Size:
21,729 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204 (See protein sequence)
Recommended Name: ADAM DEC1 precursor  
Size: 470 amino acids; 52775 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: B7ZAK5
Alternative splicing: 2 isoforms:  O15204-1   O15204-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMDEC1: NX_O15204

Explore proteomics data for ADAMDEC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15204

  • ADAMDEC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAMDEC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138743.1  NP_001138744.1  NP_055294.1  

    ENSEMBL proteins: 
     ENSP00000256412   ENSP00000428993   ENSP00000431008   ENSP00000442592  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAMDEC1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    ADAMDEC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry O15204

    ProtoNet protein and cluster: O15204

    1 Blocks protein domain: IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    ADAMDEC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADEC1_HUMAN, O15204
    Function: May play an important role in the control of the immune response and during pregnancy (By similarity)
    Induction: Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated
    by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of
    primary monocyte into macrophage

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS12037602
    GO:0008270zinc ion binding NAS12037602
         
    ADAMDEC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMDEC1:
     Synthetic lethal with Ras 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMDEC1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006955immune response NAS12037602
    GO:0007162negative regulation of cell adhesion NAS9271581

    ADAMDEC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMDEC1 (ADEC1)

    Search CenterWatch for drugs/clinical trials and news about ADAMDEC1 / ADEC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMDEC1 gene (3 alternative transcripts): 
    NM_001145271.1  NM_001145272.1  NM_014479.3  

    Unigene Cluster for ADAMDEC1:

    ADAM-like, decysin 1
    Hs.521459  [show with all ESTs]
    Unigene Representative Sequence: NM_001145271
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256412(uc003xdz.2 uc011lab.1) ENST00000522298 ENST00000520193
    ENST00000519953 ENST00000538205(uc010lub.2)
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMDEC1:
    hsa-miR-221* hsa-miR-515-5p hsa-miR-616* hsa-miR-519e* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidADAMDEC1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMDEC1
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    Additional mRNA sequence: 

    AK300959.1 AK301007.1 AK311528.1 AK316320.1 AK316322.1 BC069582.1 BC074877.2 BC074878.2 
    Y13323.2 

    5 DOTS entries:

    DT.75101654  DT.99981701  DT.121480328  DT.121480335  DT.95156682 

    24/55 AceView cDNA sequences (see all 55):

    BX481929 BX483491 BX477599 BC074877 BX483803 BX482979 NM_014479 BC069582 
    BC074878 AU136562 BE222232 BX483610 BX483432 BP345321 AV714170 BX484008 
    AI250252 BX481660 BX483763 BX483278 AI801375 BX483362 AW080321 AI830966 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMDEC1 expression in normal human tissues (normalized intensities)      ADAMDEC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAATGA
    ADAMDEC1 Expression
    About this image


    ADAMDEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Smooth Muscle (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Lower Urinary Tract (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived early endothelial progenitor cells

    See ADAMDEC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMDEC1

    SOURCE GeneReport for Unigene cluster: Hs.521459

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining
    of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC)
    of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAMDEC1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamdec11 , 5 ADAM-like, decysin 11, 5 77.44(n)1
    65.74(a)1
      14 (35.69 cM)5
    588601  NM_021475.21  NP_067450.11 
     685633875 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01068387.26
    Uncharacterized protein
    13(a)
    possible ortholog
    12(45791425-45807286)


    ENSEMBL Gene Tree for ADAMDEC1 (if available)
    TreeFam Gene Tree for ADAMDEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMDEC1 gene
    ADAM232  ADAM112  ADAM222  
    8 SIMAP similar genes for ADAMDEC1 using alignment to 2 protein entries:     ADEC1_HUMAN (see all proteins):
    ADAM28    ADAM7    ADAM19    ADAM33    ADAM8    ADAM9
    ADAM12    ADAM15

    ADAMDEC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/578 SNPs in ADAMDEC1 are shown (see all 578)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69893151,2
    C,F--24239810(+) aaaaaC/Tgtgga 3 -- us2k11Minor allele frequency- T:0.08WA 118
    rs768995261,2
    F--24239859(+) AAACTG/TGTGTA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1905491061,2
    --24239892(+) ATATAC/TGATGT 3 -- us2k10--------
    rs715158701,2
    C--24239951(+) CCATGG/TATTTG 3 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1810885451,2
    --24239997(+) AATGTC/TATTTG 3 -- us2k10--------
    rs1853723891,2
    --24240145(+) TTTGGA/GGACTC 3 -- us2k10--------
    rs1915527101,2
    --24240213(+) ATACTA/GCTCAG 3 -- us2k10--------
    rs1504490311,2
    C--24240224(+) GTGACA/GGGTAC 3 -- us2k10--------
    rs1825330131,2
    C--24240289(+) CTGTTC/TCCCAA 3 -- us2k10--------
    rs100952531,2
    C,F,H--24240339(+) GAATTA/TAAAAA 3 -- us2k1 tfbs3 trp37Minor allele frequency- T:0.04NS EA WA NA 758

    HapMap Linkage Disequilibrium report for ADAMDEC1 (24241798 - 24263526 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADAMDEC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831271CNV Gain17160897
    nsv890683CNV Gain21882294
    nsv890682CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606393    OMIM disorders: --

    7 diseases for ADAMDEC1:    About MalaCards
    pulmonary sarcoidosis    venous thromboembolism    thromboembolism    sarcoidosis
    inflammatory bowel disease    adenoma    colorectal cancer


    ADAMDEC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMDEC1
    Human Genome Epidemiology (HuGE) Navigator: ADAMDEC1 (1 document)

    Export disorders for ADAMDEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMDEC1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ADAMDEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PubMed id 9271581)1, 2, 3 Mueller C.G.F.... Liu Y.J. (1997)
    2. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PubMed id 14632642)1, 2, 9 Fritsche J....Kreutz M. (2003)
    3. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. (PubMed id 18449420)1, 4 Berger M....Schambeck C.M. (2008)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The ADAMDEC1 (decysin) gene structure: evolution by d uplication in a metalloprotease gene cluster on chromosome 8p12. (PubMed id 12037602)1, 3 Bates E.E....Mueller C.G. (2002)
    7. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. (PubMed id 11673514)1, 9 Mueller C.G....Sautes-Fridman C. (2001)
    8. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. (PubMed id 19218196)1 Crouser E.D....Eng C. (2009)
    9. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27299 HGNC: 16299 AceView: ADAMDEC1 Ensembl:ENSG00000134028 euGenes: HUgn27299
    ECgene: ADAMDEC1 H-InvDB: ADAMDEC1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMDEC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ADAMDEC1 gene:
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