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ADAMDEC1 Gene

protein-coding   GIFtS: 50
GCID: GC08P024241

ADAM-Like, Decysin 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM-Like, Decysin 11 2     decysin2
A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-12 3     Disintegrin Protease2
ADAM-Like Protein Decysin-12 3     EC 3.4.24.-3
M12.2192     DECYSIN5
ADAM DEC12     

External Ids:    HGNC: 162991   Entrez Gene: 272992   Ensembl: ENSG000001340287   OMIM: 6063935   UniProtKB: O152043   

Export aliases for ADAMDEC1 gene to outside databases

Previous GC identifers: GC08P023974 GC08P024595 GC08P024263 GC08P024297 GC08P022786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMDEC1 Gene:
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family.
Its expression is upregulated during dendritic cells maturation. This protein may play an important role in
dendritic cell function and their interactions with germinal center T cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMDEC1 Gene:
ADAMDEC1 (ADAM-like, decysin 1) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
Function: May play an important role in the control of the immune response and during pregnancy (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMDEC1 gene promoter:
         TBP   Sox5   HSF1 (long)   E4BP4   FOXO3b   FOXO4   FOXO1a   HSF1short   RSRFC4   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMDEC1 promoter sequence
   Search Chromatin IP Primers for ADAMDEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMDEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p12

ADAMDEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMDEC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P024241:  view genomic region     (about GC identifiers)

Start:
24,241,798 bp from pter      End:
24,263,526 bp from pter
Size:
21,729 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204 (See protein sequence)
Recommended Name: ADAM DEC1 precursor  
Size: 470 amino acids; 52775 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: B7ZAK5
Alternative splicing: 2 isoforms:  O15204-1   O15204-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMDEC1: NX_O15204

Explore proteomics data for ADAMDEC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61, Asn184, Asn237, Asn466
  • Modification sites at PhosphoSitePlus

  • See ADAMDEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138743.1  NP_001138744.1  NP_055294.1  

    ENSEMBL proteins: 
     ENSP00000256412   ENSP00000428993   ENSP00000431008   ENSP00000442592  

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    antibodies-online proteins for ADAMDEC1 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry O15204

    ProtoNet protein and cluster: O15204

    1 Blocks protein domain: IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    Find genes that share domains with ADAMDEC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADEC1_HUMAN, O15204
    Function: May play an important role in the control of the immune response and during pregnancy (By similarity)
    Induction: Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated
    by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of
    primary monocyte into macrophage

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS12037602
    GO:0008270zinc ion binding NAS12037602
         
    Find genes that share ontologies with ADAMDEC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMDEC1:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADAMDEC1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADEC1_HUMAN, O15204: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ADAMDEC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMDEC1
    Interactions:

        Search GeneGlobe Interaction Network for ADAMDEC1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006955immune response NAS12037602
    GO:0007162negative regulation of cell adhesion NAS9271581

    Find genes that share ontologies with ADAMDEC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMDEC1 (ADEC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMDEC1 gene (3 alternative transcripts): 
    NM_001145271.1  NM_001145272.1  NM_014479.3  

    Unigene Cluster for ADAMDEC1:

    ADAM-like, decysin 1
    Hs.521459  [show with all ESTs]
    Unigene Representative Sequence: NM_001145271
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256412(uc003xdz.2 uc011lab.1) ENST00000522298 ENST00000520193
    ENST00000519953 ENST00000538205(uc010lub.2)
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    hsa-miR-221* hsa-miR-515-5p hsa-miR-616* hsa-miR-519e* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidADAMDEC1 3' UTR sequence
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    Additional mRNA sequence: 

    AK300959.1 AK301007.1 AK311528.1 AK316320.1 AK316322.1 BC069582.1 BC074877.2 BC074878.2 
    Y13323.2 

    5 DOTS entries:

    DT.75101654  DT.99981701  DT.121480328  DT.121480335  DT.95156682 

    Selected AceView cDNA sequences (see all 55):

    BX481929 BX482979 BC069582 BX483803 NM_014479 BC074877 BX477599 BC074878 
    BX483491 BX481660 BX483610 AU136562 BX483278 AI921121 AI720171 BX483432 
    Y13323 AI830966 BX484008 AI250252 AW080321 BX483763 BE222232 AI801375 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMDEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAATGA
    ADAMDEC1 Expression
    About this image


    ADAMDEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
    ADAMDEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMDEC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521459

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining
    of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC)
    of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ADAMDEC1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamdec11 , 5 ADAM-like, decysin 11, 5 77.52(n)1
    65.74(a)1
      14 (35.69 cM)5
    588601  NM_021475.21  NP_067450.11 
     685633875 


    ENSEMBL Gene Tree for ADAMDEC1 (if available)
    TreeFam Gene Tree for ADAMDEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMDEC1 gene
    ADAM322  ADAM232  ADAM182  ADAM112  ADAM222  ADAM22  
    8 SIMAP similar genes for ADAMDEC1 using alignment to 2 protein entries:     ADEC1_HUMAN (see all proteins):
    ADAM28    ADAM7    ADAM19    ADAM33    ADAM8    ADAM9
    ADAM15    ADAM12

    Find genes that share paralogs with ADAMDEC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMDEC1 (see all 578)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69893151,2
    C,F--24239810(+) aaaaaC/Tgtgga 3 -- us2k11Minor allele frequency- T:0.08WA 118
    rs768995261,2
    F--24239859(+) AAACTG/TGTGTA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1905491061,2
    --24239892(+) ATATAC/TGATGT 3 -- us2k10--------
    rs715158701,2
    C--24239951(+) CCATGG/TATTTG 3 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1810885451,2
    --24239997(+) AATGTC/TATTTG 3 -- us2k10--------
    rs1853723891,2
    --24240145(+) TTTGGA/GGACTC 3 -- us2k10--------
    rs1915527101,2
    --24240213(+) ATACTA/GCTCAG 3 -- us2k10--------
    rs1504490311,2
    C--24240224(+) GTGACA/GGGTAC 3 -- us2k10--------
    rs1825330131,2
    C--24240289(+) CTGTTC/TCCCAA 3 -- us2k10--------
    rs100952531,2
    C,F,H--24240339(+) GAATTA/TAAAAA 3 -- us2k1 tfbs3 trp37Minor allele frequency- T:0.04NS EA WA NA 758

    HapMap Linkage Disequilibrium report for ADAMDEC1 (24241798 - 24263526 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADAMDEC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831271CNV Gain17160897
    nsv890683CNV Gain21882294
    nsv890682CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606393    OMIM disorders: --


    Find genes that share disorders with ADAMDEC1           About GenesLikeMe

    Genetic Association Database (GAD): ADAMDEC1
    Human Genome Epidemiology (HuGE) Navigator: ADAMDEC1 (1 document)

    Export disorders for ADAMDEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMDEC1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ADAMDEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PubMed id 9271581)1, 2, 3 Mueller C.G.F.... Liu Y.J. (J. Exp. Med. 1997)
    2. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PubMed id 14632642)1, 2, 9 Fritsche J....Kreutz M. (Immunology 2003)
    3. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. (PubMed id 18449420)1, 4 Berger M....Schambeck C.M. (Thromb. Haemost. 2008)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. (PubMed id 12037602)1, 3 Bates E.E....Mueller C.G. (Immunogenetics 2002)
    7. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. (PubMed id 11673514)1, 9 Mueller C.G....SautA"s-Fridman C. (J. Immunol. 2001)
    8. ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity. (PubMed id 23754285)1 Lund J....Overgaard M.T. (J. Biol. Chem. 2013)
    9. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PubMed id 19139490)2 Jia W.... Qian X.H. (Mol. Cell. Proteomics 2009)
    10. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. (PubMed id 19218196)1 Crouser E.D....Eng C. (Am. J. Respir. Crit. Care Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27299 HGNC: 16299 AceView: ADAMDEC1 Ensembl:ENSG00000134028 euGenes: HUgn27299
    ECgene: ADAMDEC1 H-InvDB: ADAMDEC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMDEC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMDEC1 gene:
    Search GeneIP for patents involving ADAMDEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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