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Aliases for ADAMDEC1 Gene

Aliases for ADAMDEC1 Gene

  • ADAM Like Decysin 1 2 3 5
  • A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-1 3 4
  • ADAM-Like Protein Decysin-1 3 4
  • Disintegrin Protease 3
  • EC 3.4.24.- 4
  • ADAM DEC1 3
  • M12.219 3
  • Decysin 3

External Ids for ADAMDEC1 Gene

Previous GeneCards Identifiers for ADAMDEC1 Gene

  • GC08P023974
  • GC08P024595
  • GC08P024263
  • GC08P022786
  • GC08P024241

Summaries for ADAMDEC1 Gene

Entrez Gene Summary for ADAMDEC1 Gene

  • This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMDEC1 Gene

ADAMDEC1 (ADAM Like Decysin 1) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM23.

UniProtKB/Swiss-Prot for ADAMDEC1 Gene

  • May play an important role in the control of the immune response and during pregnancy.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMDEC1 Gene

Genomics for ADAMDEC1 Gene

Regulatory Elements for ADAMDEC1 Gene

Enhancers for ADAMDEC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G024383 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +2.1 2143 5.4 CTCF PKNOX1 EBF1 RAD21 RELA TEAD3 ZNF547 ZNF143 SMC3 FOS ADAMDEC1 ADAM28 ADAM7 PIR51295
GH08G024360 0.9 dbSUPER 18.5 -21.7 -21680 4.1 ELF3 SIN3A FEZF1 RAD21 ZNF48 ZEB1 ZNF335 GATA2 ZNF366 SCRT2 ADAMDEC1 ENSG00000253535 ADAM28
GH08G024228 1.2 Ensembl ENCODE dbSUPER 11.8 -155.0 -154965 1.5 GTF2F1 CTCF JUN MAX EBF1 RAD21 RFX5 GATA2 SCRT2 ZNF143 ADAMDEC1 ENSG00000253535 GC08M024224 GC08M024201
GH08G024356 0.5 dbSUPER 16.9 -26.9 -26924 1.3 FOXA2 CEBPB FOXA1 ADAMDEC1 ENSG00000253535 ADAM28
GH08G024366 1.3 FANTOM5 ENCODE dbSUPER 6 -17.1 -17050 1.7 FOXA2 ARID3A CBX5 EED ETV6 CREM MTA2 BHLHE40 NR2F1 ZBED1 ADAM28 ENSG00000253535 ADAMDEC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAMDEC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMDEC1 Gene

Chromosome:
8
Start:
24,384,285 bp from pter
End:
24,406,013 bp from pter
Size:
21,729 bases
Orientation:
Plus strand

Genomic View for ADAMDEC1 Gene

Genes around ADAMDEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMDEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMDEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMDEC1 Gene

Proteins for ADAMDEC1 Gene

  • Protein details for ADAMDEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15204-ADEC1_HUMAN
    Recommended name:
    ADAM DEC1
    Protein Accession:
    O15204
    Secondary Accessions:
    • B7ZAK5

    Protein attributes for ADAMDEC1 Gene

    Size:
    470 amino acids
    Molecular mass:
    52775 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMDEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMDEC1 Gene

Post-translational modifications for ADAMDEC1 Gene

  • Glycosylation at Asn61, Asn184, posLast=237237, and posLast=466466
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMDEC1 Gene

No data available for DME Specific Peptides for ADAMDEC1 Gene

Domains & Families for ADAMDEC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAMDEC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Function for ADAMDEC1 Gene

Molecular function for ADAMDEC1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the control of the immune response and during pregnancy.
UniProtKB/Swiss-Prot Induction:
Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.

Enzyme Numbers (IUBMB) for ADAMDEC1 Gene

Gene Ontology (GO) - Molecular Function for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 9271581
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding NAS 12037602
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAMDEC1: view
genes like me logo Genes that share phenotypes with ADAMDEC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMDEC1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMDEC1 Gene

Localization for ADAMDEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMDEC1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADAMDEC1: view

Pathways & Interactions for ADAMDEC1 Gene

SuperPathways for ADAMDEC1 Gene

No Data Available

Interacting Proteins for ADAMDEC1 Gene

Gene Ontology (GO) - Biological Process for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006955 immune response NAS 12037602
GO:0007162 negative regulation of cell adhesion NAS 9271581
genes like me logo Genes that share ontologies with ADAMDEC1: view

No data available for Pathways by source and SIGNOR curated interactions for ADAMDEC1 Gene

Transcripts for ADAMDEC1 Gene

Unigene Clusters for ADAMDEC1 Gene

ADAM-like, decysin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMDEC1 Gene

No ASD Table

Relevant External Links for ADAMDEC1 Gene

GeneLoc Exon Structure for
ADAMDEC1
ECgene alternative splicing isoforms for
ADAMDEC1

Expression for ADAMDEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMDEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMDEC1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x25.5) and Colon - Transverse (x22.4).

Protein differential expression in normal tissues from HIPED for ADAMDEC1 Gene

This gene is overexpressed in Plasma (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMDEC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADAMDEC1 Gene:

ADAMDEC1

SOURCE GeneReport for Unigene cluster for ADAMDEC1 Gene:

Hs.521459

mRNA Expression by UniProt/SwissProt for ADAMDEC1 Gene:

O15204-ADEC1_HUMAN
Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

Evidence on tissue expression from TISSUES for ADAMDEC1 Gene

  • Intestine(5)
  • Lung(4.2)
  • Bone marrow(4.1)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with ADAMDEC1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMDEC1 Gene

Orthologs for ADAMDEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADAMDEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMDEC1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ADAMDEC1 34 35
  • 84.01 (n)
mouse
(Mus musculus)
Mammalia Adamdec1 34 16 35
  • 77.52 (n)
cow
(Bos Taurus)
Mammalia ADAMDEC1 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMDEC1 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMDEC1 35
  • 55 (a)
OneToOne
Species where no ortholog for ADAMDEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAMDEC1 Gene

ENSEMBL:
Gene Tree for ADAMDEC1 (if available)
TreeFam:
Gene Tree for ADAMDEC1 (if available)

Paralogs for ADAMDEC1 Gene

Paralogs for ADAMDEC1 Gene

(8) SIMAP similar genes for ADAMDEC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAMDEC1: view

Variants for ADAMDEC1 Gene

Sequence variations from dbSNP and Humsavar for ADAMDEC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000889333 -- 24,385,279(+) GTACA(A/T)AGCTG intron-variant
rs1000978217 -- 24,390,470(+) GTAAT(A/C)CCAGC intron-variant
rs1001249271 -- 24,403,412(+) TCCCA(C/G)GCATC intron-variant
rs1001274703 -- 24,396,632(+) TATCT(G/T)TCACA intron-variant
rs1001378716 -- 24,396,937(+) CCATT(G/T)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMDEC1 Gene

Variant ID Type Subtype PubMed ID
esv3572639 CNV loss 25503493
esv3891377 CNV loss 25118596
nsv831271 CNV gain 17160897

Variation tolerance for ADAMDEC1 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMDEC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAMDEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Disorders for ADAMDEC1 Gene

Relevant External Links for ADAMDEC1

Genetic Association Database (GAD)
ADAMDEC1
Human Genome Epidemiology (HuGE) Navigator
ADAMDEC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMDEC1

No disorders were found for ADAMDEC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMDEC1 Gene

Publications for ADAMDEC1 Gene

  1. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PMID: 14632642) Fritsche J. … Kreutz M. (Immunology 2003) 3 4 22 64
  2. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PMID: 9271581) Mueller C.G.F. … Liu Y.J. (J. Exp. Med. 1997) 2 3 4 64
  3. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. (PMID: 18449420) Berger M. … Schambeck C.M. (Thromb. Haemost. 2008) 3 46 64
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ADAMDEC1 Gene

Sources for ADAMDEC1 Gene

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