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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMDEC1 Gene

protein-coding   GIFtS: 49
GCID: GC08P024297

ADAM-like, decysin 1
 Explore 8 diseases affiliated with
ADAMDEC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAMDEC1    

Aliases
for ADAMDEC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM-Like, Decysin 11 2     Decysin1
M12.2191 2     Disintegrin Protease2
A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-12 3     EC 3.4.24.-3
ADAM-Like Protein Decysin-12 3     DECYSIN5
ADAM DEC12     

External Ids:    HGNC: 162991   Entrez Gene: 272992   Ensembl: ENSG000001340287   OMIM: 6063935   UniProtKB: O152043   

Export aliases for ADAMDEC1 gene to outside databases

Previous GC identifers: GC08P023974 GC08P024595 GC08P024263 GC08P022786


Summaries
for ADAMDEC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMDEC1:
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its
expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell
function and their interactions with germinal center T cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
Function: May play an important role in the control of the immune response and during pregnancy (By similarity)




Genomic Views
for ADAMDEC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMDEC1 gene promoter:
         TBP   Sox5   HSF1 (long)   E4BP4   FOXO3b   FOXO4   FOXO1a   HSF1short   RSRFC4   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMDEC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMDEC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMDEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p12

ADAMDEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMDEC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P024297:  view genomic region     (about GC identifiers)

Start:
 24,241,798 bp from pter      End:
 24,263,526 bp from pter
Size:
 21,729 bases      Orientation:
 plus strand

Proteins
for ADAMDEC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204 (See protein sequence)
Recommended Name: ADAM DEC1 precursor  
Size: 470 amino acids; 52775 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: B7ZAK5
Alternative splicing: 2 isoforms:  O15204-1   O15204-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAMDEC1: NX_O15204

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15204

    • ADAMDEC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138743.1  NP_001138744.1  NP_055294.1  

    ENSEMBL proteins: 
     ENSP00000256412   ENSP00000428993   ENSP00000431008   ENSP00000442592  

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    Uscn Proteins for ADAMDEC1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--


    ADAMDEC1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAMDEC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMDEC1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry O15204

    ProtoNet protein and cluster: O15204

    1 Blocks protein family: IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAMDEC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Function: May play an important role in the control of the immune response and during pregnancy (By similarity)
    Induction: Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by
    bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary
    monocyte into macrophage

    Enzyme Number (IUBMB): EC 3.4.24.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS12037602
    GO:0008270zinc ion binding NAS12037602


    ADAMDEC1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADAMDEC1:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for ADAMDEC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMDEC1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006955immune response NAS12037602
    GO:0007162negative regulation of cell adhesion NAS9271581


    ADAMDEC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMDEC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMDEC1
    Search CenterWatch for drugs/clinical trials and news about ADAMDEC1 / ADEC1 

    Transcripts
    for ADAMDEC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMDEC1 gene (3 alternative transcripts): 
    NM_001145271.1  NM_001145272.1  NM_014479.3  

    Unigene Cluster for ADAMDEC1:

    ADAM-like, decysin 1
    Hs.521459  [show with all ESTs]
    Unigene Representative Sequence: NM_001145271
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256412(uc003xdz.2 uc011lab.1) ENST00000522298 ENST00000520193
    ENST00000519953 ENST00000538205(uc010lub.2)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMDEC1:
    hsa-miR-221* hsa-miR-515-5p hsa-miR-616* hsa-miR-519e* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMDEC1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK300959.1 AK301007.1 AK311528.1 AK316320.1 AK316322.1 BC069582.1 BC074877.2 BC074878.2 
    Y13323.2 

    4 DOTS entries:

    DT.75101654  DT.99981701  DT.121480328  DT.121480335 

    24/55 AceView cDNA sequences (see all 55):

    BC069582 BX477599 BX483491 BC074878 BX483803 BC074877 NM_014479 BX482979 
    BX481929 AI830966 BX483432 BX481660 BX483610 AI250252 BP345321 AI720171 
    AI921121 BX483278 AW080321 AI921100 AV714170 BX483763 AV713678 BX484008 

    GeneLoc Exon Structure


    Expression
    for ADAMDEC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMDEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAAGAATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMDEC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADAMDEC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMDEC1

    SOURCE GeneReport for Unigene cluster: Hs.521459

    UniProtKB/Swiss-Prot: ADEC1_HUMAN, O15204
    Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of
    the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the
    germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC

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    In Situ
    Assay Products:     
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    Orthologs
    for ADAMDEC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ADAMDEC1 (if available)
    TreeFam Gene Tree for ADAMDEC1 (if available) 

    Paralogs
    for ADAMDEC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMDEC1 gene
    ADAM322  ADAM182  ADAM22  
    8 SIMAP similar genes for ADAMDEC1 using alignment to 2 protein entries:     ADEC1_HUMAN (see all proteins):
    ADAM28    ADAM7    ADAM19    ADAM33    ADAM8    ADAM9
    ADAM12    ADAM15

    ADAMDEC1 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMDEC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 NCBI SNPs in ADAMDEC1 are shown (see all 479)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69893151,2
    		C,F,--24239810(+) aaaaaC/Tgtgga 3 -- us2k11Minor allele frequency- T:0.08WA 118
    rs768995261,2
    		F,--24239859(+) AAACTG/TGTGTA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1905491061,2
    		--24239892(+) ATATAC/TGATGT 3 -- us2k10--------
    rs715158701,2
    		C--24239951(+) CCATGG/TATTTG 3 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1810885451,2
    		--24239997(+) AATGTC/TATTTG 3 -- us2k10--------
    rs1853723891,2
    		--24240145(+) TTTGGA/GGACTC 3 -- us2k10--------
    rs1915527101,2
    		--24240213(+) ATACTA/GCTCAG 3 -- us2k10--------
    rs1504490311,2
    		--24240224(+) GTGACA/GGGTAC 3 -- us2k10--------
    rs1825330131,2
    		--24240289(+) CTGTTC/TCCCAA 3 -- us2k10--------
    rs100952531,2
    		C,F,H,--24240339(+) GAATTA/TAAAAA 3 -- us2k1 tfbs3 trp37Minor allele frequency- T:0.04NS EA WA NA 758

    HapMap Linkage Disequilibrium report for ADAMDEC1 (24241798 - 24263526 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ADAMDEC1
         1 CNV: 4588

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    Disorders / Diseases
    for ADAMDEC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMDEC1 for disorders           About GeneDecksing

    OMIM gene information: 606393    OMIM disorders: --

    8 diseases for ADAMDEC1:    About MalaCards
    inflammatory bowel disease    pulmonary sarcoidosis    sarcoidosis    colorectal cancer
    adenoma    neuronitis    venous thromboembolism    thromboembolism

    Human Genome Epidemiology (HuGE) Navigator: ADAMDEC1 (1 document)

    Export disorders for ADAMDEC1 gene to outside databases

    Publications
    for ADAMDEC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMDEC1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ADAMDEC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PubMed id 9271581)1, 2, 3 Mueller C.G.F.... Liu Y.J. (1997)
    2. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PubMed id 14632642)1, 2, 9 Fritsche J....Kreutz M. (2003)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The ADAMDEC1 (decysin) gene structure: evolution by d uplication in a metalloprotease gene cluster on chromosome 8p12. (PubMed id 12037602)1, 3 Bates E.E....Mueller C.G. (2002)
    6. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. (PubMed id 11673514)1, 9 Mueller C.G....Sautes-Fridman C. (2001)
    7. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. (PubMed id 19218196)1 Crouser E.D....Eng C. (2009)
    8. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. (PubMed id 18449420)1 Berger M....Schambeck C.M. (2008)
    9. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for ADAMDEC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ADAMDEC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27299 HGNC: 16299 AceView: ADAMDEC1 Ensembl:ENSG00000134028 euGenes: HUgn27299
    ECgene: ADAMDEC1 H-InvDB: ADAMDEC1

    Other Databases showing ADAMDEC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAMDEC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMDEC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAMDEC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMDEC1 gene:
    Search GeneIP for patents involving ADAMDEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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