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Aliases for ADAMDEC1 Gene

Aliases for ADAMDEC1 Gene

  • ADAM-Like, Decysin 1 2 3
  • A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-1 3 4
  • ADAM-Like Protein Decysin-1 3 4
  • Decysin 3 6
  • Disintegrin Protease 3
  • EC 3.4.24.- 4
  • ADAM DEC1 3
  • M12.219 3

External Ids for ADAMDEC1 Gene

Previous GeneCards Identifiers for ADAMDEC1 Gene

  • GC08P023974
  • GC08P024595
  • GC08P024263
  • GC08P022786
  • GC08P024241

Summaries for ADAMDEC1 Gene

Entrez Gene Summary for ADAMDEC1 Gene

  • This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMDEC1 Gene

ADAMDEC1 (ADAM-Like, Decysin 1) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAMDEC1 Gene

  • May play an important role in the control of the immune response and during pregnancy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMDEC1 Gene

Genomics for ADAMDEC1 Gene

Regulatory Elements for ADAMDEC1 Gene

Genomic Location for ADAMDEC1 Gene

Start:
24,384,285 bp from pter
End:
24,406,013 bp from pter
Size:
21,729 bases
Orientation:
Plus strand

Genomic View for ADAMDEC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMDEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMDEC1 Gene

Proteins for ADAMDEC1 Gene

  • Protein details for ADAMDEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15204-ADEC1_HUMAN
    Recommended name:
    ADAM DEC1
    Protein Accession:
    O15204
    Secondary Accessions:
    • B7ZAK5

    Protein attributes for ADAMDEC1 Gene

    Size:
    470 amino acids
    Molecular mass:
    52775 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMDEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMDEC1 Gene

Proteomics data for ADAMDEC1 Gene at MOPED

Post-translational modifications for ADAMDEC1 Gene

  • Glycosylation at Asn61, Asn184, Asn237, and Asn466
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMDEC1 Gene

No data available for DME Specific Peptides for ADAMDEC1 Gene

Domains for ADAMDEC1 Gene

Protein Domains for ADAMDEC1 Gene

Graphical View of Domain Structure for InterPro Entry

O15204

UniProtKB/Swiss-Prot:

ADEC1_HUMAN :
  • O15204
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAMDEC1: view

No data available for Gene Families for ADAMDEC1 Gene

Function for ADAMDEC1 Gene

Molecular function for ADAMDEC1 Gene

UniProtKB/Swiss-Prot Function: May play an important role in the control of the immune response and during pregnancy.
UniProtKB/Swiss-Prot Induction: Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.

Enzyme Numbers (IUBMB) for ADAMDEC1 Gene

Gene Ontology (GO) - Molecular Function for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 12037602
GO:0008270 zinc ion binding NAS 12037602
genes like me logo Genes that share ontologies with ADAMDEC1: view

Phenotypes for ADAMDEC1 Gene

GenomeRNAi human phenotypes for ADAMDEC1:
genes like me logo Genes that share phenotypes with ADAMDEC1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAMDEC1 Gene

Localization for ADAMDEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMDEC1 Gene COMPARTMENTS Subcellular localization image for ADAMDEC1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADAMDEC1: view

Pathways for ADAMDEC1 Gene

SuperPathways for ADAMDEC1 Gene

No Data Available

Interacting Proteins for ADAMDEC1 Gene

Gene Ontology (GO) - Biological Process for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006955 immune response NAS 12037602
GO:0007162 negative regulation of cell adhesion NAS 9271581
genes like me logo Genes that share ontologies with ADAMDEC1: view

No data available for Pathways by source for ADAMDEC1 Gene

Transcripts for ADAMDEC1 Gene

Unigene Clusters for ADAMDEC1 Gene

ADAM-like, decysin 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMDEC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAMDEC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMDEC1 Gene

No ASD Table

Relevant External Links for ADAMDEC1 Gene

GeneLoc Exon Structure for
ADAMDEC1
ECgene alternative splicing isoforms for
ADAMDEC1

Expression for ADAMDEC1 Gene

mRNA expression in normal human tissues for ADAMDEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMDEC1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (25.5) and Colon - Transverse (22.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAMDEC1 Gene

SOURCE GeneReport for Unigene cluster for ADAMDEC1 Gene Hs.521459

mRNA Expression by UniProt/SwissProt for ADAMDEC1 Gene

O15204-ADEC1_HUMAN
Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.
genes like me logo Genes that share expressions with ADAMDEC1: view

In Situ Assay Products

Orthologs for ADAMDEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADAMDEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMDEC1 35
  • 99.29 (n)
  • 99.36 (a)
ADAMDEC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMDEC1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMDEC1 35
  • 84.01 (n)
  • 78.68 (a)
ADAMDEC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamdec1 35
  • 77.52 (n)
  • 65.74 (a)
Adamdec1 16
Adamdec1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMDEC1 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMDEC1 36
  • 55 (a)
OneToOne
Species with no ortholog for ADAMDEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAMDEC1 Gene

ENSEMBL:
Gene Tree for ADAMDEC1 (if available)
TreeFam:
Gene Tree for ADAMDEC1 (if available)

Paralogs for ADAMDEC1 Gene

Paralogs for ADAMDEC1 Gene

Selected SIMAP similar genes for ADAMDEC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAMDEC1: view

Variants for ADAMDEC1 Gene

Sequence variations from dbSNP and Humsavar for ADAMDEC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_021848 -
VAR_024598 -

Structural Variations from Database of Genomic Variants (DGV) for ADAMDEC1 Gene

Variant ID Type Subtype PubMed ID
nsv831271 CNV Gain 17160897
nsv890682 CNV Gain 21882294
nsv890683 CNV Gain 21882294

Relevant External Links for ADAMDEC1 Gene

HapMap Linkage Disequilibrium report
ADAMDEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Disorders for ADAMDEC1 Gene

Relevant External Links for ADAMDEC1

Genetic Association Database (GAD)
ADAMDEC1
Human Genome Epidemiology (HuGE) Navigator
ADAMDEC1
genes like me logo Genes that share disorders with ADAMDEC1: view

No data available for UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Publications for ADAMDEC1 Gene

  1. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PMID: 14632642) Fritsche J. … Kreutz M. (Immunology 2003) 3 4 23
  2. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PMID: 9271581) Mueller C.G.F. … Liu Y.J. (J. Exp. Med. 1997) 2 3 4
  3. The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. (PMID: 12037602) Bates E.E. … Mueller C.G. (Immunogenetics 2002) 2 3
  4. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. (PMID: 11673514) Mueller C.G. … SautA"s-Fridman C. (J. Immunol. 2001) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADAMDEC1 Gene

Sources for ADAMDEC1 Gene

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