Aliases for ADAM9 Gene
- ADAM Metallopeptidase Domain 9 2 3 5
- Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
- Cellular Disintegrin-Related Protein 3 4
- Myeloma Cell Metalloproteinase 3 4
- Cone Rod Dystrophy 9 2 3
- Mltng 3 4
- MCMP 3 4
- MDC9 3 4
- Disintegrin And Metalloproteinase Domain-Containing Protein 9 3
- A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
External Ids for ADAM9 Gene
Previous HGNC Symbols for ADAM9 Gene
Previous GeneCards Identifiers for ADAM9 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Retinitis Pigmentosa. Among its related pathways are Degradation of the extracellular matrix and A-beta Pathways: Plaque Formation and APP Metabolism. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot for ADAM9 Gene
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).