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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM9 Gene

protein-coding   GIFtS: 73
GCID: GC08P038871

ADAM Metallopeptidase Domain 9

(Previous names: a disintegrin and metalloproteinase domain 9 (meltrin gamma),...)
(Previous symbol: CORD9)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADAM Metallopeptidase Domain 91 2     Mltng2
CORD91 2 5     ADAM Metallopeptidase Domain 9 (Meltrin Gamma)2
MCMP2 3 5     Disintegrin And Metalloproteinase Domain-Containing Protein 92
MDC92 3 5     EC 3.4.24.-3
Cone Rod Dystrophy 91 2     KIAA00213
Cellular Disintegrin-Related Protein2 3     MLTNG3
Metalloprotease/Disintegrin/Cysteine-Rich Protein 92 3     Meltrin-gamma3
Myeloma Cell Metalloproteinase2 3     ADAM 93
A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma)1     EC 3.4.248
Meltrin Gamma1     

External Ids:    HGNC: 2161   Entrez Gene: 87542   Ensembl: ENSG000001686157   OMIM: 6027135   UniProtKB: Q134433   
ORGUL members:         
NONCODE14:n407940      

Export aliases for ADAM9 gene to outside databases

Previous GC identifers: GC08P038441 GC08P039068 GC08P038595 GC08P038974 GC08P038975 GC08P037387


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM9 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins,
binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of
membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have
been identified for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for ADAM9 Gene: 
ADAM9 (ADAM metallopeptidase domain 9) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ADAM9 include cone-rod dystrophy 9, and myeloma, and among its related super-pathways are Degradation of the extracellular matrix and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include integrin binding and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays
alpha-secretase activity for APP

Gene Wiki entry for ADAM9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM9 gene promoter:
         HFH-3   SRF   AML1a   SRF (504 AA)   Pax-2   Pax-2a   YY1   FOXL1   FOXI1   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.23

ADAM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM9 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038871:  view genomic region     (about GC identifiers)

Start:
38,854,388 bp from pter      End:
38,962,780 bp from pter
Size:
108,393 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 9 precursor  
Size: 819 amino acids; 90556 Da
Cofactor: Binds 1 zinc ion per subunit (Probable)
Subunit: Interacts with SH3GL2 and SNX9 through its cytoplasmic tail
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Caution: Has sometimes been referred to as ADAM-12
1 PDB 3D structure from and Proteopedia for ADAM9:
1M1V (3D)    
Secondary accessions: B7ZLN7 Q10718 Q8NFM6
Alternative splicing: 2 isoforms:  Q13443-1   Q13443-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADAM9: NX_Q13443

Explore proteomics data for ADAM9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13443

  • 4/6 DME Specific Peptides for ADAM9 (Q13443) (see all 6)
     LVGLEIW  GEECDCG  HELGHNLG  KCHGHGVC 

    ADAM9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAM9 Protein Expression
    REFSEQ proteins: NP_003807.1  
    ENSEMBL proteins: 
     ENSP00000420257   ENSP00000417066   ENSP00000419446   ENSP00000418437   ENSP00000418737  
     ENSP00000369249  
    Reactome Protein details: Q13443
    Human Recombinant Protein Products for ADAM9: 
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    Cloud-Clone Corp. Proteins for ADAM9 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS8647900
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0009986cell surface ISS8647900
    GO:0016021integral to membrane IEA--

    ADAM9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM9 
    ADAM

    5/8 InterPro protein domains (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13443

    ProtoNet protein and cluster: Q13443

    4 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM9_HUMAN, Q13443
    Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays
    alpha-secretase activity for APP

         Genatlas biochemistry entry for ADAM9:
    a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely
    expressed,also expressed in meyloma cells

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IMP--
    GO:0005080protein kinase C binding ISS8647900
    GO:0005178integrin binding IPI17704059
    GO:0005515protein binding IPI10527948
    GO:0005518collagen binding IMP15361064
         
    ADAM9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADAM9:
     G0/1 arrest  Increased G1 DNA content  Increases Tamoxifen sensitivit 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adam9):
     cardiovascular system  mortality/aging  normal  vision/eye 

    ADAM9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam9tm1Bbl for ADAM9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM9 
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    SwitchGear 3'UTR luciferase reporter plasmidADAM9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAM9 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Degradation of collagen0.79
    2Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    3Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADAM9
        Development Endothelin-1/EDNRA transactivation of EGFR

    1 R&D Systems Pathway for ADAM9
        A-beta Plaque Formation & APP Metabolism


    2 Cell Signaling Technology (CST) Pathways for ADAM9
        Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ADAM9
        Development Endothelin-1/EDNRA transactivation of EGFR

    1 Sino Biological Pathway for ADAM9 
        Notch Signaling Pathway

    3        Reactome Pathways for ADAM9
        Extracellular matrix organization
    Degradation of the extracellular matrix
    Degradation of collagen



    ADAM9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM9

    5/19 Interacting proteins for ADAM9 (Q134431, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L2Q9UI951, 2, 3EBI-77903,EBI-77889 MINT-15197 MINT-15198 I2D: score=5 
    SH3GL2Q999621, 3EBI-77903,EBI-77938 I2D: score=3 
    PACSIN3Q9UKS61, 3EBI-77903,EBI-77926 I2D: score=2 
    ENSG00000204490P013753I2D: score=2 
    ENSG00000206439P013753I2D: score=2 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA17704059
    GO:0006508proteolysis ----
    GO:0006509membrane protein ectodomain proteolysis IMP--
    GO:0007155cell adhesion IMP11162558
    GO:0007160cell-matrix adhesion IMP15361064

    ADAM9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM9

    1 HMDB Compound for ADAM9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Clotrimazole(Chlorotrityl)imidazole (see all 72)23593-75-1--

    2 Novoseek inferred chemical compound relationships for ADAM9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 0 2 17018608 (1), 17342749 (1)
    h2o2 0 7 17018608 (4), 17342749 (2)

    Search CenterWatch for drugs/clinical trials and news about ADAM9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAM9 gene (2 alternative transcripts): 
    NM_003816.2  NM_001005845.1  

    Unigene Cluster for ADAM9:

    ADAM metallopeptidase domain 9
    Hs.591852  [show with all ESTs]
    Unigene Representative Sequence: NM_003816
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466936 ENST00000481513(uc003xmp.3) ENST00000487273(uc003xmr.3)
    ENST00000481873(uc010lwr.3) ENST00000468065(uc011lcg.2) ENST00000379917(uc011lcf.2)
    ENST00000481058 ENST00000484143 ENST00000463437

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    Additional mRNA sequence: 

    AF495383.1 AK293257.1 BC027996.1 BC126406.1 BC143923.1 BC143924.1 D14665.2 NR_027638.1 
    NR_027639.1 NR_027878.1 U41766.1 

    14 DOTS entries:

    DT.95290333  DT.100036234  DT.314189  DT.100806951  DT.121637964  DT.91647234  DT.101969807  DT.100758569 
    DT.100818732  DT.121475923  DT.121475942  DT.121475966  DT.121475954  DT.91642847 

    24/198 AceView cDNA sequences (see all 198):

    BQ006587 BM980421 AW338313 U41766 CB044420 AA584283 BQ224598 BM852524 
    BQ004509 BU156026 CA423541 AI499571 BF088319 AL701949 AI801062 BI856382 
    AI866710 BG163442 D14665 AF495383 BX490480 CB243457 AI383616 CB265379 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM9 expression in normal human tissues (normalized intensities)      ADAM9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATATTA
    ADAM9 Expression
    About this image


    ADAM9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Myocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells

    See ADAM9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM9

    SOURCE GeneReport for Unigene cluster: Hs.591852

    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
    Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart

        SABiosciences Expression via Pathway-Focused PCR Array including ADAM9: 
              Alzheimer's Disease in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAM9 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam91 , 5 a disintegrin and metallopeptidase domain 9 (meltrin gamma) less1, 5 83.33(n)1
    86.15(a)1
      8 (13.70 cM)5
    115021  NM_007404.21  NP_031430.21 
     249496115 
    chicken
    (Gallus gallus)
    Aves ADAM91 ADAM metallopeptidase domain 9 71.87(n)
    71.82(a)
      426781  NM_001031396.1  NP_001026567.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM96
    --
    --
    59(a)
    45(a)
    1 ↔ 1
    possible ortholog
    GL343418.1(557904-594761)
    3(59937330-59973406)
    African clawed frog
    (Xenopus laevis)
    Amphibia adam9-A2 a disintegrin and metalloproteinase domain 9 77.44(n)    AF032382.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adam96
    zgc:1741646
    zgc:174164
    59(a)
    40(a)
    1 ↔ 1
    possible ortholog
    8(48004002-48093554)
    12(12421893-12455943)
    fruit fly
    (Drosophila melanogaster)
    Insecta mmd3 metalloendopeptidase 35(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea adm-13 Disintegrin 27(a)   III(12952834-12963248)   --


    ENSEMBL Gene Tree for ADAM9 (if available)
    TreeFam Gene Tree for ADAM9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM9 gene
    ADAM72  ADAM322  ADAM192  ADAM122  ADAM182  ADAM332  ADAM302  ADAM22  
    ADAM282  ADAM292  ADAM202  ADAM212  ADAM152  ADAM82  
    16 SIMAP similar genes for ADAM9 using alignment to 5 protein entries:     ADAM9_HUMAN (see all proteins):
    ADAM12    ADAM21    ADAM30    ADAM19    ADAM18    ADAM20
    ADAM28    ADAM23    ADAM29    ADAMDEC1    ADAM15    ADAM8
    ADAM7    ADAM2    ADAM22    ADAM11

    ADAM9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2128 SNPs in ADAM9 are shown (see all 2128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378530411,2
    Cpathogenic139102511(+) TTTATC/TGAATG 5 R * stg10--------
    rs2002324331,2
    C--37392673(+) GAATTC/TTTTTT 4 -- int10--------
    rs1996732991,2
    --37409312(+) TCTTC-/TTTTCC 4 -- int10--------
    rs64745181,2
    C,A--37409315(+) TCTTTC/TCCATG 4 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs64745191,2
    C,A--37409317(+) TTTTCC/TATGAA 4 -- int1 trp35Minor allele frequency- T:0.45WA NA EA 362
    rs2001159541,2
    --37409317(+) TTTCC-/TATGAA 4 -- int10--------
    rs106522131,2
    C--37417191(+) CTGGG-/TTCT  
            
    TTCTT
    4 -- int1 trp30--------
    rs113139001,2
    C--37426737(+) GACTTC/-CTAAT 4 -- int12Minor allele frequency- -:0.00NA 4
    rs1918620621,2
    --37435652(+) ATATAC/TGTGTA 4 -- int10--------
    rs1383925961,2
    C--37435661(+) TATATA/GTGTGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for ADAM9 (38854388 - 38962780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADAM9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2795CNV Deletion18987735
    esv2736897CNV Deletion23290073
    esv2659169CNV Deletion23128226
    esv270261CNV Insertion20981092
    nsv6162CNV Insertion18451855
    esv1147428CNV Insertion17803354
    esv272925CNV Insertion20981092
    nsv524818CNV Loss19592680
    esv9208CNV Gain19470904
    nsv515080CNV Complex21397061


    Human Gene Mutation Database (HGMD): ADAM9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM9
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602713   
    OMIM disorders: 612775  
    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
  • Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal
    pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone
    photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central
    visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis
    pigmentosa. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/30 diseases for ADAM9 (see all 30):    About MalaCards
    cone-rod dystrophy 9    myeloma    alveolar soft part sarcoma    skin melanoma
    cone-rod dystrophy    adenoid cystic carcinoma    wegener's granulomatosis    adenoiditis
    gastrointestinal stromal tumor    prostate adenocarcinoma    cataract    retinal degeneration
    skin cancer    retinitis pigmentosa    myopathy    retinitis
    prostate cancer    prostatitis    sarcoma    melanoma

    1 disease from the University of Copenhagen DISEASES database for ADAM9:
    cone-rod dystrophy

    ADAM9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for ADAM9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 26.6 4 19473694 (1), 18582378 (1), 19146682 (1)
    tumors 24.1 15 14532978 (3), 19505527 (2), 15930291 (1), 16230393 (1) (see all 7)
    prostate cancer 23.6 19 17018608 (6), 18061337 (5), 16230393 (3), 17342749 (2) (see all 5)
    aggressiveness 22.4 2 14997207 (1), 12717386 (1)
    liver metastases 18.4 2 15930291 (1), 12717386 (1)
    cancer 17.5 9 19473694 (2), 19601830 (2), 19408347 (1), 17355265 (1) (see all 6)
    breast carcinoma 7.03 1 12767059 (1)
    cataract 1.74 4 11955914 (3), 14551530 (1)
    necrosis 0.53 4 10527948 (1), 11463349 (1)
    carcinoma 0 7 15930291 (2), 16230393 (2), 12767059 (1), 12717386 (1)

    Genetic Association Database (GAD): ADAM9
    Human Genome Epidemiology (HuGE) Navigator: ADAM9 (1 document)

    Export disorders for ADAM9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM9 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with ADAM9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PubMed id 8647900)1, 2, 3, 9 Weskamp G.... Blobel C.P. (1996)
    2. Loss of the metalloprotease ADAM9 leads to cone-rod d ystrophy in humans and retinal degeneration in mice. (PubMed id 19409519)1, 2, 3 Parry D.A....Inglehearn C.F. (2009)
    3. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PubMed id 19237226)1, 4 Cong L. and Jia J. (2009)
    4. A secreted form of human ADAM9 has an alpha-secretase activity for APP. (PubMed id 12054541)1, 2 Hotoda N.... Ishiura S. (2002)
    5. CORD9 a new locus for arCRD: mapping to 8p11, estimat ion of frequency, evaluation of a candidate gene. (PubMed id 11581183)1, 3 Danciger M....Farber D.B. (2001)
    6. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)1, 2 Howard L.... Blobel C.P. (1999)
    7. Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. (PubMed id 9016778)1, 2 McKie N.... Croucher P.I. (1997)
    8. Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. (PubMed id 8809033)1, 2 McKie N....Croucher P.I. (1996)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    10. Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. (PubMed id 19473694)1, 9 Zubel A....Alonso A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8754 HGNC: 216 AceView: ADAM9 Ensembl:ENSG00000168615 euGenes: HUgn8754
    ECgene: ADAM9 H-InvDB: ADAM9

    (According to HUGE)
    About This Section
    HUGE: KIAA0021

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAM9 gene:
    Search GeneIP for patents involving ADAM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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