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Aliases for ADAM9 Gene

Aliases for ADAM9 Gene

  • ADAM Metallopeptidase Domain 9 2 3
  • Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
  • Cellular Disintegrin-Related Protein 3 4
  • Myeloma Cell Metalloproteinase 3 4
  • Cone Rod Dystrophy 9 2 3
  • Mltng 3 4
  • MCMP 3 4
  • MDC9 3 4
  • A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
  • ADAM Metallopeptidase Domain 9 (Meltrin Gamma) 3
  • Meltrin Gamma 2
  • Meltrin-Gamma 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • KIAA0021 4
  • ADAM 9 4
  • CORD9 3

External Ids for ADAM9 Gene

Previous HGNC Symbols for ADAM9 Gene

  • CORD9

Previous GeneCards Identifiers for ADAM9 Gene

  • GC08P038441
  • GC08P039068
  • GC08P038595
  • GC08P038871
  • GC08P038974
  • GC08P037387

Summaries for ADAM9 Gene

Entrez Gene Summary for ADAM9 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAM9 Gene

ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include cone-rod dystrophy 9 and cone-rod dystrophy. Among its related pathways are Degradation of the extracellular matrix and Adhesion. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM9 Gene

  • Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Gene Wiki entry for ADAM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM9 Gene

Genomics for ADAM9 Gene

Regulatory Elements for ADAM9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAM9 Gene

38,996,869 bp from pter
39,105,261 bp from pter
108,393 bases
Plus strand

Genomic View for ADAM9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM9 Gene

Proteins for ADAM9 Gene

  • Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B7ZLN7
    • Q10718
    • Q8NFM6

    Protein attributes for ADAM9 Gene

    819 amino acids
    Molecular mass:
    90556 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with SH3GL2 and SNX9 through its cytoplasmic tail.

    Three dimensional structures from OCA and Proteopedia for ADAM9 Gene

    Alternative splice isoforms for ADAM9 Gene


neXtProt entry for ADAM9 Gene

Proteomics data for ADAM9 Gene at MOPED

Selected DME Specific Peptides for ADAM9 Gene

Post-translational modifications for ADAM9 Gene

  • Glycosylation at Asn 125, Asn 144, Asn 154, Asn 231, Asn 381, and Asn 487
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM9 (ADAM9)

Domains & Families for ADAM9 Gene

Gene Families for ADAM9 Gene

Suggested Antigen Peptide Sequences for ADAM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 disintegrin domain.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM9: view

Function for ADAM9 Gene

Molecular function for ADAM9 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
UniProtKB/Swiss-Prot Function:
Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Enzyme Numbers (IUBMB) for ADAM9 Gene

Gene Ontology (GO) - Molecular Function for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IMP 22480688
GO:0005080 protein kinase C binding ISS 8647900
GO:0005178 integrin binding IPI 17704059
GO:0005515 protein binding IPI 10527948
GO:0005518 collagen binding IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view
genes like me logo Genes that share phenotypes with ADAM9: view

Animal Models for ADAM9 Gene

MGI Knock Outs for ADAM9:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM9

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAM9 Gene

Localization for ADAM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for ADAM9 Gene COMPARTMENTS Subcellular localization image for ADAM9 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space ISS 8647900
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ADAM9: view

Pathways & Interactions for ADAM9 Gene

genes like me logo Genes that share pathways with ADAM9: view

Pathways by source for ADAM9 Gene

1 Sino Biological pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene
1 R&D Systems pathway for ADAM9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ADAM9 Gene


Gene Ontology (GO) - Biological Process for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 17704059
GO:0006508 proteolysis --
GO:0006509 membrane protein ectodomain proteolysis IMP 22480688
GO:0007155 cell adhesion IMP 11162558
GO:0007160 cell-matrix adhesion IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view

Drugs & Compounds for ADAM9 Gene

(2) Drugs for ADAM9 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved Pharma Channel blocker Cytochrome P450 inhibitor; antifungal 24
INCB7839 Investigational Pharma Target 0

(2) Additional Compounds for ADAM9 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
genes like me logo Genes that share compounds with ADAM9: view

Transcripts for ADAM9 Gene

Unigene Clusters for ADAM9 Gene

ADAM metallopeptidase domain 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM9 Gene

No ASD Table

Relevant External Links for ADAM9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM9 Gene

mRNA expression in normal human tissues for ADAM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAM9 Gene

This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAM9 Gene

SOURCE GeneReport for Unigene cluster for ADAM9 Gene Hs.591852

mRNA Expression by UniProt/SwissProt for ADAM9 Gene

Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
genes like me logo Genes that share expression patterns with ADAM9: view

Protein tissue co-expression partners for ADAM9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADAM9 Gene

Orthologs for ADAM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAM9 35
  • 87.3 (n)
  • 85.59 (a)
ADAM-9 36
  • 86 (a)
(Canis familiaris)
Mammalia ADAM9 35
  • 92.23 (n)
  • 92.55 (a)
ADAM9 36
  • 90 (a)
(Mus musculus)
Mammalia Adam9 35
  • 83.97 (n)
  • 87.06 (a)
Adam9 16
Adam9 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADAM9 35
  • 99.76 (n)
  • 99.76 (a)
ADAM9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adam9 35
  • 83.84 (n)
  • 86.29 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
-- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ADAM9 36
  • 76 (a)
(Gallus gallus)
Aves ADAM9 35
  • 70.25 (n)
  • 68.95 (a)
ADAM9 36
  • 71 (a)
(Anolis carolinensis)
Reptilia ADAM9 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adam9 35
  • 67.54 (n)
  • 70.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia adam9-A 35
(Danio rerio)
Actinopterygii adam9 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 35 (a)
Neu3 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 27 (a)
adm-2 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 36 (a)
Species with no ortholog for ADAM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM9 Gene

Gene Tree for ADAM9 (if available)
Gene Tree for ADAM9 (if available)

Paralogs for ADAM9 Gene

genes like me logo Genes that share paralogs with ADAM9: view

Variants for ADAM9 Gene

Sequence variations from dbSNP and Humsavar for ADAM9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3208797 -- 39,078,171(+) TGTTT(C/T)TCACT intron-variant
rs4075849 -- 39,077,064(+) TCTGC(C/T)GTATT intron-variant
rs4128871 -- 39,002,475(+) CACCA(C/T)GCCCG intron-variant
rs4129095 -- 39,039,202(+) CTGCT(A/G)CTACT intron-variant
rs4130393 -- 39,083,415(-) TCTAA(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM9 Gene

Variant ID Type Subtype PubMed ID
nsv515080 CNV Complex 21397061
esv270261 CNV Insertion 20981092
esv272925 CNV Insertion 20981092
esv1147428 CNV Insertion 17803354
esv9208 CNV Gain 19470904
nsv524818 CNV Loss 19592680
esv2795 CNV Deletion 18987735
esv2736897 CNV Deletion 23290073
esv2659169 CNV Deletion 23128226
nsv6162 CNV Insertion 18451855

Variation tolerance for ADAM9 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene

Disorders for ADAM9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADAM9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cone-rod dystrophy 9
  • retinitis pigmentosa 9
cone-rod dystrophy
  • cone-rod dystrophy 5
alveolar soft-part sarcoma
  • alveolar soft part sarcoma
- elite association
Search ADAM9 in MalaCards View complete list of genes associated with diseases


  • Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADAM9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADAM9: view

No data available for Genatlas for ADAM9 Gene

Publications for ADAM9 Gene

  1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G. … Blobel C.P. (J. Cell Biol. 1996) 2 23 67
  2. Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma. (PMID: 20395004) Kohga K. … Hayashi N. (J. Hepatol. 2010) 23 67
  3. Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. (PMID: 20305301) Stokes A. … KAohAori V.M. (Clin. Cancer Res. 2010) 23 67
  4. Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) IA9eri O.D. … GA1ndA1z U. (Cancer Chemother. Pharmacol. 2010) 23 67
  5. Fluorescent substrates useful as high-throughput screening tools for ADAM9. (PMID: 20015014) Moss M.L. … Williams J. (Comb. Chem. High Throughput Screen. 2010) 23 67

Products for ADAM9 Gene

Sources for ADAM9 Gene

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