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Aliases for ADAM9 Gene

Aliases for ADAM9 Gene

  • ADAM Metallopeptidase Domain 9 2 3 5
  • Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
  • Cellular Disintegrin-Related Protein 3 4
  • Myeloma Cell Metalloproteinase 3 4
  • Cone Rod Dystrophy 9 2 3
  • Mltng 3 4
  • MCMP 3 4
  • MDC9 3 4
  • A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
  • ADAM Metallopeptidase Domain 9 (Meltrin Gamma) 3
  • Meltrin Gamma 2
  • Meltrin-Gamma 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • KIAA0021 4
  • ADAM 9 4
  • CORD9 3

External Ids for ADAM9 Gene

Previous HGNC Symbols for ADAM9 Gene

  • CORD9

Previous GeneCards Identifiers for ADAM9 Gene

  • GC08P038441
  • GC08P039068
  • GC08P038595
  • GC08P038871
  • GC08P038974
  • GC08P037387

Summaries for ADAM9 Gene

Entrez Gene Summary for ADAM9 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAM9 Gene

ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include cone-rod dystrophy 9 and retinitis pigmentosa. Among its related pathways are Adhesion and Cytoskeletal Signaling. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM9 Gene

  • Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Gene Wiki entry for ADAM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM9 Gene

Genomics for ADAM9 Gene

Regulatory Elements for ADAM9 Gene

Enhancers for ADAM9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAM9 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM9 Gene

Chromosome:
8
Start:
38,996,869 bp from pter
End:
39,105,261 bp from pter
Size:
108,393 bases
Orientation:
Plus strand

Genomic View for ADAM9 Gene

Genes around ADAM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM9 Gene

Proteins for ADAM9 Gene

  • Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13443-ADAM9_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 9
    Protein Accession:
    Q13443
    Secondary Accessions:
    • B7ZLN7
    • Q10718
    • Q8NFM6

    Protein attributes for ADAM9 Gene

    Size:
    819 amino acids
    Molecular mass:
    90556 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with SH3GL2 and SNX9 through its cytoplasmic tail.

    Three dimensional structures from OCA and Proteopedia for ADAM9 Gene

    Alternative splice isoforms for ADAM9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM9 Gene

Proteomics data for ADAM9 Gene at MOPED

Selected DME Specific Peptides for ADAM9 Gene

Post-translational modifications for ADAM9 Gene

  • Glycosylation at Asn 125, Asn 144, Asn 154, Asn 231, Asn 381, and Asn 487
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM9 (ADAM9)

Domains & Families for ADAM9 Gene

Gene Families for ADAM9 Gene

Suggested Antigen Peptide Sequences for ADAM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13443

UniProtKB/Swiss-Prot:

ADAM9_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM9: view

Function for ADAM9 Gene

Molecular function for ADAM9 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
UniProtKB/Swiss-Prot Function:
Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Enzyme Numbers (IUBMB) for ADAM9 Gene

Gene Ontology (GO) - Molecular Function for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM9: view
genes like me logo Genes that share phenotypes with ADAM9: view

Human Phenotype Ontology for ADAM9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADAM9 Gene

MGI Knock Outs for ADAM9:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAM9 Gene

Localization for ADAM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM9 Gene COMPARTMENTS Subcellular localization image for ADAM9 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ADAM9: view

Pathways & Interactions for ADAM9 Gene

genes like me logo Genes that share pathways with ADAM9: view

Pathways by source for ADAM9 Gene

1 Sino Biological pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene

SIGNOR curated interactions for ADAM9 Gene

Activates:

Gene Ontology (GO) - Biological Process for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IMP 15361064
GO:0010042 response to manganese ion IMP 11162558
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0033630 positive regulation of cell adhesion mediated by integrin IMP 11162558
genes like me logo Genes that share ontologies with ADAM9: view

Drugs & Compounds for ADAM9 Gene

(2) Drugs for ADAM9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved Pharma Inhibition, Pore Blocker Cytochrome P450 inhibitor; antifungal 30
INCB7839 Investigational Pharma Target 0

(2) Additional Compounds for ADAM9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM9: view

Transcripts for ADAM9 Gene

Unigene Clusters for ADAM9 Gene

ADAM metallopeptidase domain 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM9 Gene

No ASD Table

Relevant External Links for ADAM9 Gene

GeneLoc Exon Structure for
ADAM9
ECgene alternative splicing isoforms for
ADAM9

Expression for ADAM9 Gene

mRNA expression in normal human tissues for ADAM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAM9 Gene

This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADAM9 Gene



SOURCE GeneReport for Unigene cluster for ADAM9 Gene Hs.591852

mRNA Expression by UniProt/SwissProt for ADAM9 Gene

Q13443-ADAM9_HUMAN
Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
genes like me logo Genes that share expression patterns with ADAM9: view

Protein tissue co-expression partners for ADAM9 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ADAM9 Gene

Orthologs for ADAM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM9 35
  • 87.3 (n)
  • 85.59 (a)
ADAM-9 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM9 35
  • 92.23 (n)
  • 92.55 (a)
ADAM9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam9 35
  • 83.97 (n)
  • 87.06 (a)
Adam9 16
Adam9 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM9 35
  • 99.76 (n)
  • 99.76 (a)
ADAM9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam9 35
  • 83.84 (n)
  • 86.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM9 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM9 35
  • 70.25 (n)
  • 68.95 (a)
ADAM9 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM9 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam9 35
  • 67.54 (n)
  • 70.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia adam9-A 35
zebrafish
(Danio rerio)
Actinopterygii adam9 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 35 (a)
Neu3 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 27 (a)
adm-2 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ADAM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM9 Gene

ENSEMBL:
Gene Tree for ADAM9 (if available)
TreeFam:
Gene Tree for ADAM9 (if available)

Paralogs for ADAM9 Gene

genes like me logo Genes that share paralogs with ADAM9: view

Variants for ADAM9 Gene

Sequence variations from dbSNP and Humsavar for ADAM9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7830975 -- 39,032,008(+) cagaa(C/T)agcaa intron-variant
rs7832284 -- 39,058,085(+) aaagt(G/T)atgtt intron-variant
rs7832578 -- 39,019,896(+) AAGCA(C/T)ATGGA intron-variant
rs7833611 -- 39,014,667(+) TATAC(A/C)TTTTT intron-variant
rs7833803 -- 39,045,872(+) accaa(G/T)atcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM9 Gene

Variant ID Type Subtype PubMed ID
nsv515080 CNV Complex 21397061
esv270261 CNV Insertion 20981092
esv272925 CNV Insertion 20981092
esv1147428 CNV Insertion 17803354
esv9208 CNV Gain 19470904
nsv524818 CNV Loss 19592680
esv2795 CNV Deletion 18987735
esv2736897 CNV Deletion 23290073
esv2659169 CNV Deletion 23128226
nsv6162 CNV Insertion 18451855

Variation tolerance for ADAM9 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM9 Gene

HapMap Linkage Disequilibrium report
ADAM9
Human Gene Mutation Database (HGMD)
ADAM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene

Disorders for ADAM9 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADAM9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cone-rod dystrophy 9
  • retinitis pigmentosa 9
retinitis pigmentosa
  • retinitis pigmentosa 1
cone-rod dystrophy
  • cone-rod dystrophy 5
alveolar soft-part sarcoma
  • alveolar soft part sarcoma
skin melanoma
  • melanoma
- elite association - COSMIC cancer census association via MalaCards
Search ADAM9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ADAM9_HUMAN
  • Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADAM9

Genetic Association Database (GAD)
ADAM9
Human Genome Epidemiology (HuGE) Navigator
ADAM9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM9
genes like me logo Genes that share disorders with ADAM9: view

No data available for Genatlas for ADAM9 Gene

Publications for ADAM9 Gene

  1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G. … Blobel C.P. (J. Cell Biol. 1996) 2 3 4 23 67
  2. Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) IA9eri O.D. … GA1ndA1z U. (Cancer Chemother. Pharmacol. 2010) 3 23
  3. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry D.A. … Inglehearn C.F. (Am. J. Hum. Genet. 2009) 2 3
  4. ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. (PMID: 19253070) Oksala N. … LehtimAoki T. (Ann. Med. 2009) 3 23
  5. Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism. (PMID: 19394555) Bakken A.M. … Davies M.G. (J. Vasc. Surg. 2009) 3 23

Products for ADAM9 Gene

Sources for ADAM9 Gene

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