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Aliases for ADAM9 Gene

Aliases for ADAM9 Gene

  • ADAM Metallopeptidase Domain 9 2 3 5
  • Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
  • Cellular Disintegrin-Related Protein 3 4
  • Myeloma Cell Metalloproteinase 3 4
  • Cone Rod Dystrophy 9 2 3
  • Mltng 3 4
  • MCMP 3 4
  • MDC9 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 9 3
  • A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
  • ADAM Metallopeptidase Domain 9 (Meltrin Gamma) 3
  • Meltrin Gamma 2
  • Meltrin-Gamma 4
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • KIAA0021 4
  • ADAM 9 4
  • CORD9 3

External Ids for ADAM9 Gene

Previous HGNC Symbols for ADAM9 Gene

  • CORD9

Previous GeneCards Identifiers for ADAM9 Gene

  • GC08P038441
  • GC08P039068
  • GC08P038595
  • GC08P038871
  • GC08P038974
  • GC08P037387

Summaries for ADAM9 Gene

Entrez Gene Summary for ADAM9 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAM9 Gene

ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Retinitis Pigmentosa. Among its related pathways are A-beta Signaling Pathways and Adhesion. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM12.

UniProtKB/Swiss-Prot for ADAM9 Gene

  • Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.

  • Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).

Gene Wiki entry for ADAM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM9 Gene

Genomics for ADAM9 Gene

Regulatory Elements for ADAM9 Gene

Enhancers for ADAM9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F039035 1.6 FANTOM5 Ensembl ENCODE 17.2 +41.0 40973 5.5 ATF1 SIN3A YY1 FOS ZNF202 JUNB NFIL3 MBD2 MEF2D MAFF ADAM32 ADAM9 TM2D2 ENSG00000255201 ENSG00000272128 HTRA4 TACC1 PLEKHA2 GC08M039018 ENSG00000207199
GH08F039032 1.3 Ensembl ENCODE 12.8 +36.2 36230 2.2 KLF17 ARID4B SIN3A ZNF48 GTF3C2 KLF7 EGR2 SP3 SP5 IKZF1 ADAM32 ADAM9 ENSG00000207199 GC08M039018
GH08F039040 0.5 ENCODE 12.3 +43.9 43903 0.2 ZNF585B ENSG00000207199 ADAM9 TM2D2 GC08M039018 ADAM32
GH08F039041 0.5 Ensembl ENCODE 12.3 +45.3 45316 2.0 HDGF SIN3A RAD21 ZNF335 ZNF121 SCRT2 ZNF143 FOS CREM SMAD5 ADAM32 ENSG00000207199 ADAM9 TM2D2 ENSG00000272128 GC08M039018
GH08F038966 1.1 Ensembl ENCODE 11.7 -30.3 -30313 0.3 CTCF ZNF175 RAD21 RFX5 FOSL1 SMC3 TRIM24 NFE2 ZNF654 TRIM22 TM2D2 ADAM32 PLEKHA2 ADAM9 ENSG00000253645
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAM9 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001390353 831 5001 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ADAM9 Gene

Chromosome:
8
Start:
38,996,869 bp from pter
End:
39,105,261 bp from pter
Size:
108,393 bases
Orientation:
Plus strand

Genomic View for ADAM9 Gene

Genes around ADAM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM9 Gene

Proteins for ADAM9 Gene

  • Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13443-ADAM9_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 9
    Protein Accession:
    Q13443
    Secondary Accessions:
    • B7ZLN7
    • Q10718
    • Q8NFM6

    Protein attributes for ADAM9 Gene

    Size:
    819 amino acids
    Molecular mass:
    90556 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.

    Three dimensional structures from OCA and Proteopedia for ADAM9 Gene

    Alternative splice isoforms for ADAM9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM9 Gene

Selected DME Specific Peptides for ADAM9 Gene

Q13443:
  • RYVELFIVVD
  • GEECDCG
  • LVGLEIW
  • GGSVDSGP
  • HELGHNLG
  • KCHGHGVC

Post-translational modifications for ADAM9 Gene

  • Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
  • Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
  • Glycosylation at Asn 125, Asn 144, Asn 154, Asn 231, Asn 381, and Asn 487
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM9 (ADAM9)
  • Abcam antibodies for ADAM9
  • Cloud-Clone Corp. Antibodies for ADAM9

Domains & Families for ADAM9 Gene

Gene Families for ADAM9 Gene

Suggested Antigen Peptide Sequences for ADAM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13443

UniProtKB/Swiss-Prot:

ADAM9_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM9: view

Function for ADAM9 Gene

Molecular function for ADAM9 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
UniProtKB/Swiss-Prot EnzymeRegulation:
Synthesized as an inactive form which is proteolytically cleaved to generate an active enzyme. Processing at the upstream site is particularly important for activation of the proenzyme, whereas processing at the boundary between the pro-domain and the catalytic domain does not appear to be essential. Inhibited by hydroxamic acid-based inhibitors.
UniProtKB/Swiss-Prot Function:
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
UniProtKB/Swiss-Prot Function:
Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).

Enzyme Numbers (IUBMB) for ADAM9 Gene

Gene Ontology (GO) - Molecular Function for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IMP 22480688
GO:0005080 protein kinase C binding ISS 8647900
GO:0005178 integrin binding IPI 17704059
GO:0005515 protein binding IPI 10527948
GO:0005518 collagen binding IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view
genes like me logo Genes that share phenotypes with ADAM9: view

Human Phenotype Ontology for ADAM9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADAM9 Gene

MGI Knock Outs for ADAM9:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAM9 Gene

Localization for ADAM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM9 Gene COMPARTMENTS Subcellular localization image for ADAM9 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS 8647900
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface ISS 8647900
genes like me logo Genes that share ontologies with ADAM9: view

Pathways & Interactions for ADAM9 Gene

genes like me logo Genes that share pathways with ADAM9: view

Pathways by source for ADAM9 Gene

1 Sino Biological pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene

SIGNOR curated interactions for ADAM9 Gene

Activates:

Gene Ontology (GO) - Biological Process for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 17704059
GO:0006508 proteolysis IEA --
GO:0006509 membrane protein ectodomain proteolysis IMP 22480688
GO:0007155 cell adhesion IMP 11162558
GO:0007160 cell-matrix adhesion IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view

Drugs & Compounds for ADAM9 Gene

(3) Drugs for ADAM9 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker Cytochrome P450 inhibitor; antifungal 35
INCB7839 Investigational Pharma Target 0

(1) Additional Compounds for ADAM9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM9: view

Transcripts for ADAM9 Gene

Unigene Clusters for ADAM9 Gene

ADAM metallopeptidase domain 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM9 Gene

No ASD Table

Relevant External Links for ADAM9 Gene

GeneLoc Exon Structure for
ADAM9
ECgene alternative splicing isoforms for
ADAM9

Expression for ADAM9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAM9 Gene

This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM9 Gene



Protein tissue co-expression partners for ADAM9 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM9 Gene:

ADAM9

SOURCE GeneReport for Unigene cluster for ADAM9 Gene:

Hs.591852

mRNA Expression by UniProt/SwissProt for ADAM9 Gene:

Q13443-ADAM9_HUMAN
Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
genes like me logo Genes that share expression patterns with ADAM9: view

Primer Products

No data available for mRNA differential expression in normal tissues for ADAM9 Gene

Orthologs for ADAM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM9 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia ADAM9 34 35
  • 92.23 (n)
cow
(Bos Taurus)
Mammalia ADAM9 34
  • 87.3 (n)
ADAM-9 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam9 34 16 35
  • 83.97 (n)
rat
(Rattus norvegicus)
Mammalia Adam9 34
  • 83.84 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM9 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM9 34 35
  • 70.25 (n)
lizard
(Anolis carolinensis)
Reptilia ADAM9 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam9 34
  • 67.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia adam9-A 34
zebrafish
(Danio rerio)
Actinopterygii adam9 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 36
  • 35 (a)
Neu3 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 27 (a)
adm-2 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for ADAM9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM9 Gene

ENSEMBL:
Gene Tree for ADAM9 (if available)
TreeFam:
Gene Tree for ADAM9 (if available)

Paralogs for ADAM9 Gene

genes like me logo Genes that share paralogs with ADAM9: view

Variants for ADAM9 Gene

Sequence variations from dbSNP and Humsavar for ADAM9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137853040 Pathogenic 39,023,177(+) ATATT(C/T)GAATT nc-transcript-variant, reference, stop-gained
rs137853041 Pathogenic 39,017,298(+) TTTAT(C/G/T)GAATG nc-transcript-variant, reference, missense, stop-gained
rs786205085 Pathogenic 39,026,811(+) GCATC(A/G)TGAGT splice-donor-variant
rs786205086 Pathogenic 39,017,211(+) ATGCA(A/G)CATTC intron-variant
rs786205151 Pathogenic 39,055,575(+) TCACT(A/G)GTTCC splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM9 Gene

Variant ID Type Subtype PubMed ID
esv1147428 CNV insertion 17803354
esv2659169 CNV deletion 23128226
esv2736897 CNV deletion 23290073
esv2795 CNV loss 18987735
esv3543384 CNV deletion 23714750
esv3543385 CNV deletion 23714750
esv9208 CNV gain 19470904
nsv1076079 CNV deletion 25765185
nsv1115088 CNV deletion 24896259
nsv1118049 CNV deletion 24896259
nsv1136005 CNV deletion 24896259
nsv1148609 CNV deletion 26484159
nsv1151331 CNV insertion 26484159
nsv477373 CNV novel sequence insertion 20440878
nsv515080 CNV gain 21397061
nsv524818 CNV loss 19592680
nsv6162 CNV insertion 18451855

Variation tolerance for ADAM9 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM9 Gene

Human Gene Mutation Database (HGMD)
ADAM9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene

Disorders for ADAM9 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ADAM9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cone-rod dystrophy 9
  • retinitis pigmentosa 9
retinitis pigmentosa
  • retinitis pigmentosa 1
cone-rod dystrophy
  • cone-rod retinal dystrophy-2
alveolar soft-part sarcoma
  • alveolar soft part sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search ADAM9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ADAM9_HUMAN
  • Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADAM9

Genetic Association Database (GAD)
ADAM9
Human Genome Epidemiology (HuGE) Navigator
ADAM9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM9
genes like me logo Genes that share disorders with ADAM9: view

No data available for Genatlas for ADAM9 Gene

Publications for ADAM9 Gene

  1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G. … Blobel C.P. (J. Cell Biol. 1996) 2 3 4 22 64
  2. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry D.A. … Inglehearn C.F. (Am. J. Hum. Genet. 2009) 2 3 4 64
  3. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PMID: 19237226) Cong L. … Jia J. (Neurobiol. Aging 2011) 3 46 64
  4. Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) IA9eri O.D. … GA1ndA1z U. (Cancer Chemother. Pharmacol. 2010) 3 22 64
  5. ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. (PMID: 19253070) Oksala N. … LehtimAoki T. (Ann. Med. 2009) 3 22 64

Products for ADAM9 Gene

Sources for ADAM9 Gene

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