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ADAM9 Gene

protein-coding GIFtS: 69

GC08P038974

ADAM metallopeptidase domain 9 (meltrin gamma)
(Previous name: a disintegrin and metalloproteinase domain 9 (meltrin gamma) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.- ^³
KIAA0021 ^¹, ², ³
MCMP ^¹, ², ³, ⁵
MDC9 ^¹, ², ³, ⁵
MLTNG ^³
Meltrin-gamma ^³
Mltng ^¹, ²

Descriptions
ADAM 9 ^³
ADAM metallopeptidase domain 9 ^²
ADAM metallopeptidase domain 9 (meltrin gamma) ^²
Cellular disintegrin-related protein ^², ³
Metalloprotease/disintegrin/cysteine-rich protein 9 ^³
Myeloma cell metalloproteinase ^², ³
a disintegrin and metalloproteinase domain 9 (meltrin gamma) ^¹, ²
meltrin gamma ^²

External Ids
HGNC: 216¹
Entrez Gene: 8754²
UniProtKB: Q13443³
Ensembl: ENSG00000168615⁷

Search outside databases for aliases for ADAM9 gene

Previous GC identifers: GC08P038441 GC08P039068 GC08P038595 GC08P038871

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM9:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members

of this family are membrane-anchored proteins structurally related to snake venom disintegrins,

and have been implicated in a variety of biological processes involving cell-cell and cell-matrix

interactions, including fertilization, muscle development, and neurogenesis. The protein encoded

by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta

protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored

heparin-binding EGF-like growth factor. Two alternative splice variants have been identified,

encoding distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443

Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2

displays alpha-secretase activity for APP

Gene Wiki entry for ADAM9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM9 gene

Entrez Gene cytogenetic band: 8p11.23 Ensembl cytogenetic band: 8p11.23 HGNC cytogenetic band: 8p11.23

ADAM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P038974: (about GC identifiers)

Start:	38,973,662 bp from pter
End:	39,081,937 bp from pter
Size:	108,276 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 9 precursor

Size: 819 amino acids; 90556 Da

Cofactor: Binds 1 zinc ion per subunit (Probable)

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Caution: Has sometimes been referred to as ADAM-12

PDB structures from and Proteopedia :

1M1V (3D)

Secondary accessions: Q10718 Q8NFM6

Alternative splicing: 2 isoforms: Q13443-1 Q13443-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001005845.1 NP_003807.1

ENSEMBL proteins:

ENSP00000369249 ENSP00000305538

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAM9
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM9)
	Human Recombinant Proteins from Abnova (ADAM9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	ISS	8647900
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	ISS	8647900

About this table

Antibodies for ADAM9:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM9
	Sigma-Aldrich Antibodies for ADAM9
	R&D Systems Antibodies for ADAM9
	Cell Signaling Technology (CST) Antibodies for ADAM9
	Antibodies from Abcam (ADAM9), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM9)
	Novus Biologicals Antibody for ADAM9

Assays for ADAM9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ADAM9 (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13443

ProtoNet protein and cluster: Q13443

4 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006210 Type I EGF

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003816

Applied Biosystems Silencer® siRNAs for ADAM9

Sigma-Aldrich siRNA and siRNA Panels for ADAM9

Sigma-Aldrich shRNA for ADAM9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001005845
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001005845
untagged cDNA clones in CMV expression vector (see all 4): BC027996

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003816

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443

Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2

displays alpha-secretase activity for APP

Enzyme Number (IUBMB): EC 3.4.24.-

Genatlas biochemistry entry for ADAM9:

a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion

protein,widely expressed,also expressed in meyloma cells

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adam9):

lethality-prenatal/perinatal

normal

vision/eye

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005080	protein kinase C binding	ISS	8647900
GO:0005178	integrin binding	IPI	17704059
GO:0005518	collagen binding	IMP	15361064
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM9 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks ADAM9 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADAM9

5/12 Interacting proteins for ADAM9 (ENSP00000369249³ Q13443^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PACSIN3	Q9UKS6¹	STRING (score=.801) EBI-77903, EBI-77926
SH3GL2	Q99962¹	STRING (score=.958) EBI-77903, EBI-77938
MAD2L2	Q9UI95¹^,²	STRING (score=.974) EBI-77903, EBI-77889 MINT-15197 MINT-15198 EBI-77903, EBI-77889 MINT-15197 MINT-15198
MAD2L2	Q9UI95¹^,²	STRING (score=.974) EBI-77903, EBI-77889 MINT-15197 MINT-15198 EBI-77903, EBI-77889 MINT-15197 MINT-15198
SNX9	ENSP00000252631³	STRING (score=.936)

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5/20 Gene Ontology (GO) biological process terms (links to tree view) (see all 20 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	IDA	17704059
GO:0006508	proteolysis	IEA	--
GO:0006979	response to oxidative stress	IEP	17018608
GO:0007160	cell-matrix adhesion	IMP	15361064
GO:0007179	transforming growth factor beta receptor signaling pathway	ISS	8647900

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM9

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM9
1 Novoseek chemical compound relationship for ADAM9 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen	0.00	2	17018608 (1), 17342749 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003816

Sigma-Aldrich siRNA and siRNA Panels for ADAM9

Sigma-Aldrich shRNA for ADAM9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001005845 NM_003816

REFSEQ mRNAs for ADAM9 gene (2 alternative transcripts):

NM_001005845.1 NM_003816.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001005845 NM_003816

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001005845
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001005845
                                 untagged cDNA clones in CMV expression vector (see all 4): BC027996

Additional cDNA sequence:

AF495383.1 AK293257.1 BC027996.1 BC126406.1 BC143923.1 BC143924.1 CR591969.1 CR601711.1

D14665.2 U41766.1

13 DOTS entries:

DT.95290333 DT.100036234 DT.314189 DT.100758569 DT.100806951 DT.91647234 DT.101969807 DT.100818732

DT.121475923 DT.121475942 DT.121475954 DT.121475966 DT.91642847

24/198 AceView cDNA sequences (see all 198 ):

AI499571 BI856382 BM977289 BQ006587 CD677250 BX490480 BM852524 NM_003816

AL701949 CR601711 BM973396 BG163442 AU133113 BQ224598 U41766 BF088319

CB265379 BQ023774 BQ029957 BG036016 AW338313 H59231 CA423541 BQ775360

highest scoring ESTs for ADAM9:

U41766 AA065135 AA314599 AA363627 AA373320 AA506729 AA528429 AA584283 AA853771 AA863211

Unigene Cluster for ADAM9:

ADAM metallopeptidase domain 9 (meltrin gamma)

Hs.591852 [show with all ESTs]

Unigene Representative Sequence: NM_003816

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000379917 ENST00000302458

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADAM9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM9

¹ / ² / ³

4 probe-sets matching ADAM9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34761_r_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U41766	1.00	1.00	1.00	1
202381_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003816	0.60	1.00	0.82	1
1555326_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202381_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAATATTA

SOURCE GeneReport for Unigene cluster: Hs.591852
Expression variation in blood from EXPOLDB for ADAM9
UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
Tissue specificity: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2
found in liver and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM9 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAM9¹	--	ADAM metallopeptidase domain 9 (meltrin gamma)	92.14(n) 92.55(a)	475579 XM_532798.2 XP_532798.2
chimpanzee (Pan troglodytes)	ADAM9¹	--	ADAM metallopeptidase domain 9 (meltrin gamma)	99.76(n) 99.76(a)	464129 XM_519719.2 XP_519719.2
cow (Bos taurus)	ADAM9¹	--	ADAM metallopeptidase domain 9 (meltrin gamma)	87.51(n) 86.08(a)	281600 XM_614306.3 XP_614306.3
rat (Rattus norvegicus)	Adam9¹	--	ADAM metallopeptidase domain 9 (meltrin gamma)	83.29(n) 85.29(a)	290834 NM_001014772.1 NP_001014772.1
mouse (Mus musculus)	Adam9^{1, 5}	8 (8.00 cM)⁵	a disintegrin and metallopeptidase domain 9 (meltrin more^{1, 5}	83.5(n)¹ 86.27(a)¹	11502¹ NM_007404.1¹ NP_031430.1¹ AA561243⁵ AK122188⁵ (see all 18)

About this table Species with no ortholog for ADAM9

ENSEMBL Gene Tree for ADAM9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM9 gene

ADAM29² ADAM20² ADAM21P² ADAM30²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/467 NCBI SNPs in ADAM9 are shown (see all 467 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 146)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4733973^1,2	C,F,H	39080707(+)	`TAAGAT/GTTTTG`	2	--	ut3¹		7	EU EA WA NA	560
	rs35438678^1,2	F	39018709(-)	`GGCTTT/CGGAAT`	2	P/P	syn¹		1	NA	36
	rs7836006^1,2	A,C,F,H	39013405(+)	`ACTGTG/AGCCTC`	2	--	int¹		4	EU EA WA	410
	rs6474526^1,2	A,C,F,H	39056923(+)	`TTGTTT/GCAGTG`	2	--	int¹		11	NA EU EA WA	888
	rs4367507^1,2	A,C,F,H	38996245(-)	`CTAAAT/CATGTG`	2	--	int¹		7	NA EU EA WA	550
	rs10089487^1,2	A,C,F,H	38977641(+)	`GGGACG/ATTCCC`	2	--	int¹		4	EU EA WA	416
	rs4733967^1,2	A,C,F,H	38992165(+)	`GATGGA/TGTCTC`	2	--	int¹		7	NA EU EA WA	542
	rs6995969^1,2	A,C,F,H	38980156(+)	`ATTTGA/GAATTT`	2	--	int¹		7	EU EA WA NA	560
	rs9643905^1,2	A,C,F,H	39031110(+)	`GTATTA/CATGTC`	2	--	int¹		4	EU EA WA	408
	rs6474524^1,2	A,C,F,H	39050905(+)	`AGATAC/TTTCCT`	2	--	int¹		7	EU EA WA NA	560

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HapMap Linkage Disequilibrium images for ADAM9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602713

10 Novoseek disease relationships for ADAM9 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	27.31	19	17018608 (6), 18061337 (5), 16230393 (3), 17342749 (2) (see all 5)
aggressiveness	26.06	2	14997207 (1), 12717386 (1)
liver metastases	21.76	2	15930291 (1), 12717386 (1)
metastasis	10.28	3	18582378 (1), 19146682 (1)
breast carcinoma	10.20	1	12767059 (1)
tumors	7.77	12	14532978 (3), 15930291 (1), 16230393 (1), 12717386 (1) (see all 5)
cancer	5.89	5	19408347 (1), 12767059 (1), 16230393 (1), 17355265 (1)
cataract	5.15	4	11955914 (3), 14551530 (1)
carcinoma	3.14	7	15930291 (2), 16230393 (2), 12767059 (1), 12717386 (1)
necrosis	0.00	4	10527948 (1), 11463349 (1)

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Human Genome Epidemiology Navigator: ADAM9 (1 document)

(Possibly Related Articles in Doctor's Guide)
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New Test May Accurately Measure Patients' Response to Cystic Fibrosis Therapy

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/69 PubMed articles for ADAM9 gene (see all 69 ):

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PubMed id 8647900)^{1, 2, 3, 4} Weskamp G.... Blobel C.P. (1996)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
A secreted form of human ADAM9 has an alpha-secretase activity for APP. (PubMed id 12054541)^{3, 4} Hotoda N.... Ishiura S. (2002)
Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. (PubMed id 9016778)^{3, 4} McKie N.... Croucher P.I. (1997)
Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. (PubMed id 8809033)^{3, 4} McKie N....Croucher P.I. (1996)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{3, 4} Nomura N....Tabata S. (1994)
Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. (PubMed id 17018608)^{1, 3} Sung S.Y....Chung L.W. (2006)
ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. (PubMed id 14997207)^{1, 3} Grutzmann R....Pilarsky C. (2004)
Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells. (PubMed id 17342749)^{1, 3} Shigemura K....Chung L.W. (2007)
Adam-9 expression and regulation in human skin melanoma and melanoma cell lines. (PubMed id 15856464)^{1, 3} Zigrino P....Nischt R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8754	HGNC: 216	AceView: ADAM9	Ensembl:ENSG00000168615	euGenes: HUgn8754
ECgene: ADAM9	H-InvDB: ADAM9

(According to HUGE)
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HUGE: KIAA0021

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ADAM9	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ADAM9
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADAM9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM9		Antibodies for ADAM9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADAM9)
	Antibodies (ADAM9)
	Chimera RNAi (ADAM9)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ADAM9

	Recombinant Proteins (ADAM9)
	Antibodies (ADAM9)

Search OriGene for ADAM9

Search Tocris compounds for ADAM9

	Drugs for ADAM9
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADAM9

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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ADAM9 Gene at Home site.
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ADAM9 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ADAM9

Summaries
for ADAM9

Genomic Location
for ADAM9

Proteins
for ADAM9

Protein Domains/
Families
for ADAM9

Gene Function
for ADAM9

Pathways & Interactions
for ADAM9

Drugs & Compounds
for ADAM9

Transcripts
for ADAM9

Expression
for ADAM9

Orthologs
for ADAM9

Paralogs
for ADAM9

SNPs/Variants
for ADAM9

Disorders & Mutations
for ADAM9

Medical News
for ADAM9

Publications
for ADAM9

Search for ADAM9

Genome Databases showing ADAM9

Other Databases showing ADAM9

Specialized Databases showing ADAM9

Licensable Technologies
for ADAM9

Services
for ADAM9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM9 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ADAM9

Summariesfor ADAM9

Genomic Locationfor ADAM9

Proteinsfor ADAM9

Protein Domains/Familiesfor ADAM9

Gene Functionfor ADAM9

Pathways & Interactionsfor ADAM9

Drugs & Compoundsfor ADAM9

Transcriptsfor ADAM9

Expression for ADAM9

Orthologsfor ADAM9

Paralogsfor ADAM9

SNPs/Variantsfor ADAM9

Disorders & Mutationsfor ADAM9

Medical Newsfor ADAM9

Publicationsfor ADAM9

Search for ADAM9

Genome Databases showing ADAM9

Other Databases showing ADAM9

Specialized Databases showing ADAM9

Licensable Technologiesfor ADAM9

Servicesfor ADAM9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM9

Summaries
for ADAM9

Genomic Location
for ADAM9

Proteins
for ADAM9

Protein Domains/
Families
for ADAM9

Gene Function
for ADAM9

Pathways & Interactions
for ADAM9

Drugs & Compounds
for ADAM9

Transcripts
for ADAM9

Expression
for ADAM9

Orthologs
for ADAM9

Paralogs
for ADAM9

SNPs/Variants
for ADAM9

Disorders & Mutations
for ADAM9

Medical News
for ADAM9

Publications
for ADAM9

Licensable Technologies
for ADAM9

Services
for ADAM9