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Aliases & Descriptions for ADAM8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD156 1, 2, 5 | | EC 3.4.24.- 3 | | MGC134985 2 | | MS2 1, 2, 3 | | OTTHUMP00000020792 2 |
| | | Descriptions |
|---|
| ADAM 8 3 | | ADAM metallopeptidase domain 8 2 | | CD156a antigen 2, 3 | | Cell surface antigen MS2 2, 3 | | a disintegrin and metalloproteinase domain 8 1, 2 |
|
| | Search outside databases for aliases for ADAM8 genePrevious GC identifers: GC10M133990 GC10M134205 GC10M134992 GC10M134549 |
Summaries for ADAM8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ADAM8: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration. [provided by RefSeq] UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325Function: Possible involvement in extravasation of leukocytesGene Wiki entry for ADAM8 |
Genomic Location for ADAM8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ADAM8 gene 
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3ADAM8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M134964:
(about GC identifiers)
Start:
|
134,925,911 bp from pter |
End:
|
134,940,362 bp from pter |
Size:
|
14,452 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_017795.18
| Proteins for ADAM8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 8 precursor Size: 824 amino acids; 88673 Da
Cofactor: Binds 1 zinc ion per subunit (Probable)
Subcellular location: Membrane; Single-pass type I membrane proteinREFSEQ proteins: NP_001100.2
ENSEMBL proteins: ENSP00000357554
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ADAM8: Assays for ADAM8: | Protein
Domains/ Families for ADAM8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P78325
ProtoNet protein and cluster: P78325 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006210 Type I EGF
UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325Similarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain | Gene Function for ADAM8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001109
Applied Biosystems Silencer® siRNAs for ADAM8
Sigma-Aldrich siRNA and siRNA Panels for ADAM8  Sigma-Aldrich shRNA Panels and shRNA for ADAM8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001109                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001109                                  untagged cDNA clone in CMV expression vector: NM_001109 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001109
UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325Function: Possible involvement in extravasation of leukocytesEnzyme Number (IUBMB): EC 3.4.24.- Genatlas biochemistry entry for ADAM8:a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Adam8):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ADAM8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM8 (Your Favorite Gene powered by Ingenuity) 
--2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0016337 | cell-cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for ADAM8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for ADAM8 |
Browse Tocris compounds for ADAM8 1 Novoseek chemical compound relationship for ADAM8 gene
About this table
|
Transcripts for ADAM8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001109
Sigma-Aldrich siRNA and siRNA Panels for ADAM8  Sigma-Aldrich shRNA Panels and shRNA for ADAM8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001109 REFSEQ mRNAs for ADAM8 gene: NM_001109.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001109               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001109                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001109                                  untagged cDNA clone in CMV expression vector: NM_001109  Additional cDNA sequence: AK301147.1 AK304324.1 AK310662.1 AK312834.1 BC064500.1 BC115404.1 D26579.1 5 DOTS entries: DT.211684 DT.101968108 DT.91662946 DT.95107243 DT.102824678 24/77 AceView cDNA sequences (see all 77
):AW450964 BQ582246 BF513621 AI686614 AA279188 BU579727 BM894152 AW296645 BQ007791 BM875345 BQ687228 AI479652 AI814527 D26579 BF062736 NM_001109 AI240862 BM146234 BU542259 BM850301 AW770687 AA865449 BQ708311 BF512208
highest scoring ESTs for ADAM8:D26579 BC064500 BE243136 BI768819 BI907784 BM146234 BM146278 BM146783 BM837639 BQ689657 Unigene Cluster for ADAM8: ADAM metallopeptidase domain 8 Hs.501574 [show with all ESTs]Unigene Representative Sequence: NM_001109
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ADAM8
1 Ensembl transcript including schematic representation: ENST00000368566
|
Expression for ADAM8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADAM8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADAM8
1 / 2 / 3 5 probe-sets matching ADAM8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGATTCAAGA
SOURCE GeneReport for Unigene cluster: Hs.501574
Expression variation in blood from EXPOLDB for ADAM8 UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325Tissue specificity: Expressed on neutrophils and monocytes |
Orthologs for ADAM8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADAM8 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ADAM8
ENSEMBL Gene Tree for ADAM8 | Paralogs for ADAM8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ADAM8 gene
- ADAM72 ADAMDEC12 ADAM282
|
SNPs/Variants for ADAM8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADAM8 (up to first 250kb)
|
Disorders & Mutations for ADAM8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602267
9 Novoseek disease relationships for ADAM8 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| preterm delivery |
31.82 |
6 |
16638589 (5) |
| asthma |
26.81 |
22 |
19397475 (6), 17339047 (4), 18691140 (3), 17088949 (1) (see all 5) |
| inflammation |
24.79 |
10 |
17308171 (2), 16542157 (2), 18691140 (1), 12966612 (1) (see all 6) |
| neurodegeneration |
24.51 |
7 |
11050116 (3), 16542157 (2) |
| tumors |
10.22 |
9 |
16772875 (3), 15538223 (1), 11050116 (1), 18710625 (1) (see all 5) |
| necrosis |
8.16 |
1 |
11050116 (1) |
| cancer lung |
4.01 |
8 |
15623614 (7) |
| cancer |
3.80 |
1 |
17355265 (1) |
| metastasis |
0.00 |
3 |
15538223 (1), 18710625 (1), 14719095 (1) |
About this table
Human Genome Epidemiology Navigator: ADAM8 (1 document)
|
Medical News for ADAM8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ADAM8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/36 PubMed articles for ADAM8 gene (see all 36
):- CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PubMed id 9126482)1, 2, 3, 4 Yoshiyama K.... Yamamoto S. (1997)
- ADAM8 as a novel serological and histochemical marker for lung cancer. (PubMed id 15623614)1, 3 Ishikawa N....Nakamura Y. (2004)
- Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration. (PubMed id 11050116)1, 3 Schlomann U....Bartsch J.W. (2000)
- ADAM8 in allergy. (PubMed id 18691140)1, 3 Matsuno O....Higuchi Y. (2008)
- Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. (PubMed id 19284887)1, 3 Ma G.F....Konttinen Y.T. (2009)
- Increased expression of ADAM33 and ADAM8 with disease progression in asthma. (PubMed id 17339047)1, 3 Foley S.C....Hamid Q. (2007)
- Hypoxia-dependent expression of ADAM8 in human pancreatic cancer cell lines. (PubMed id 18566576)3 Valkovskaya N.V. (2008)
- Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)3 Tremblay K....Laprise C. (2008)
- ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer. (PubMed id 17979891)3 Valkovskaya N....Kleeff J. (2007)
- Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. (PubMed id 17548643)3 Gomez-Gaviro M....Diaz-Gonzalez F. (2007)
|
Search for ADAM8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ADAM8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADAM8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ADAM8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ADAM8:

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