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ADAM8 Gene

protein-coding   GIFtS: 66
GCID: GC10M135075

ADAM Metallopeptidase Domain 8

(Previous name: a disintegrin and metalloproteinase domain 8)
  See ADAM8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 81 2     Disintegrin And Metalloproteinase Domain-Containing Protein 82
A Disintegrin And Metalloproteinase Domain 81 2     Human Leukocyte Differentiation Antigen2
Cell Surface Antigen MS22 3     EC 3.4.24.-3
MS22 3     ADAM 83
CD1562 5     CD156a Antigen3
CD156a2     EC 3.4.248

External Ids:    HGNC: 2151   Entrez Gene: 1012   Ensembl: ENSG000001516517   OMIM: 6022675   UniProtKB: P783253   

Export aliases for ADAM8 gene to outside databases

Previous GC identifers: GC10M133990 GC10M134205 GC10M134992 GC10M134549 GC10M134964 GC10M134925 GC10M128622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM8 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during
neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2009)

GeneCards Summary for ADAM8 Gene:
ADAM8 (ADAM metallopeptidase domain 8) is a protein-coding gene. Diseases associated with ADAM8 include asthma. GO annotations related to this gene include metallopeptidase activity and calcium ion binding. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
Function: Possible involvement in extravasation of leukocytes

Gene Wiki entry for ADAM8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM8 gene promoter:
         Bach1   AML1a   Tal-1   Pax-2   IRF-1   Pax-2a   E47   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM8 promoter sequence
   Search Chromatin IP Primers for ADAM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

ADAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135075:  view genomic region     (about GC identifiers)

Start:
135,075,907 bp from pter      End:
135,090,407 bp from pter
Size:
14,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 8 precursor  
Size: 824 amino acids; 88771 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with FST3
1 PDB 3D structure from and Proteopedia for ADAM8:
4DD8 (3D)    
Secondary accessions: B4DVM6 H0YL36 H0YLR0 H0YN39
Alternative splicing: 3 isoforms:  P78325-1   P78325-2   P78325-3   (No experimental confirmation available. Ref.4 (BC064500) sequence is in conflict in position: 693:A->S)

Explore the universe of human proteins at neXtProt for ADAM8: NX_P78325

Explore proteomics data for ADAM8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn91, Asn436, Asn612
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ADAM8 (P78325)
     LVGLEIW  MAHEMGH  GHNLGMDHD 


    See ADAM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001100.3  NP_001157961.1  NP_001157962.1  

    ENSEMBL proteins: 
     ENSP00000453302   ENSP00000453855   ENSP00000453043   ENSP00000452994   ENSP00000453735  
    Reactome Protein details: P78325

    ADAM8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADAM8

     
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    ADAM8 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM8
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry P78325

    ProtoNet protein and cluster: P78325

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Find genes that share domains with ADAM8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM8_HUMAN, P78325
    Function: Possible involvement in extravasation of leukocytes

         Genatlas biochemistry entry for ADAM8:
    a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen
    MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI12777399
    GO:0008237metallopeptidase activity IDA12777399
    GO:0008270zinc ion binding TAS18397961
         
    Find genes that share ontologies with ADAM8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAM8:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adam8):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  normal 
     skeleton 

    Find genes that share phenotypes with ADAM8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adam8tm1.1Rood for ADAM8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM8
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM8

    miRNA
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    miRTarBase miRNAs that target ADAM8:
    hsa-mir-335-5p (MIRT019009)

    Block miRNA regulation of human, mouse, rat ADAM8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ADAM8:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidADAM8 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for ADAM8
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADAM8_HUMAN, P78325: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    lysosome4
    plasma membrane4
    vacuole4
    extracellular2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA15220135
    GO:0005737cytoplasm IDA18397961
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA18397961
    GO:0009986cell surface IDA17548643

    Find genes that share ontologies with ADAM8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM8 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    3Notch Signaling Pathway (sino)
    Notch Signaling Pathway


    Find genes that share SuperPaths with ADAM8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ADAM8
        Notch Signaling Pathway

    1 Reactome Pathway for ADAM8
        Degradation of the extracellular matrix


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM8
    Interactions:

        Search GeneGlobe Interaction Network for ADAM8

    2 Interacting proteins for ADAM8 (P783253) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FSTP198833I2D: score=1 
    FSTL3O956333I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ISS--
    GO:0001525angiogenesis ISS--
    GO:0002523leukocyte migration involved in inflammatory response ISS--
    GO:0002675positive regulation of acute inflammatory response ISS--
    GO:0002693positive regulation of cellular extravasation ----

    Find genes that share ontologies with ADAM8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM8

    1 Novoseek inferred chemical compound relationship for ADAM8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 33.4 4 18691140 (1), 17270707 (1), 17339047 (1)



    Find genes that share compounds with ADAM8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAM8 gene (3 alternative transcripts): 
    NM_001109.4  NM_001164489.1  NM_001164490.1  

    Unigene Cluster for ADAM8:

    ADAM metallopeptidase domain 8
    Hs.501574  [show with all ESTs]
    Unigene Representative Sequence: NM_001109
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445355(uc021qbe.1 uc009ybi.3 uc010qva.2 uc009ybj.2)
    ENST00000415217 ENST00000485491 ENST00000559018 ENST00000468964 ENST00000561175
    ENST00000537099(uc010qvb.1) ENST00000560135 ENST00000463298 ENST00000486609
    ENST00000559180
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADAM8:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidADAM8 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ADAM8
      QuantiFast Probe-based Assays in human, mouse, rat ADAM8

    Additional mRNA sequence: 

    AK301147.1 AK304324.1 AK310662.1 AK312834.1 BC064500.1 BC115404.1 D26579.1 

    5 DOTS entries:

    DT.211684  DT.101968108  DT.91662946  DT.95107243  DT.102824678 

    Selected AceView cDNA sequences (see all 77):

    BQ007791 AW450964 AW296645 AI686614 BQ582246 BM894152 BU579727 BM875345 
    AA279188 BF513621 BQ687228 BM768621 AW770687 BC064500 BM850301 BE858211 
    BG231530 D26579 BI768819 BQ689657 BM843289 BF512208 BM146234 BU542259 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                          -     -     -                                                                                                                     
    SP4:                                                        -                                                                                                   
    SP5:                    -     -                                                                                                                                 

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
    SP1:                                -                           
    SP2:        -     -                 -                           
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for ADAM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTCAAGA
    ADAM8 Expression
    About this image


    ADAM8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
    ADAM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501574

    UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
    Tissue specificity: Expressed on neutrophils and monocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam81 , 5 a disintegrin and metallopeptidase domain 81, 5 72.3(n)1
    65.08(a)1
      7 (84.96 cM)5
    115011  NM_007403.21  NP_031429.11 
     1399789325 
    chicken
    (Gallus gallus)
    Aves ADAM81 ADAM metallopeptidase domain 8 57.81(n)
    48.65(a)
      423672  XM_004941987.1  XP_004942044.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adam8b1 a disintegrin and metalloproteinase domain 8b 49.47(n)
    42.48(a)
      100005593  XM_003199573.2  XP_003199621.2 


    ENSEMBL Gene Tree for ADAM8 (if available)
    TreeFam Gene Tree for ADAM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM8 gene
    ADAM72  ADAM192  ADAM122  ADAM332  ADAM302  ADAM282  ADAM292  ADAM202  
    ADAM212  ADAM92  ADAM152  
    7 SIMAP similar genes for ADAM8 using alignment to 4 protein entries:     ADAM8_HUMAN (see all proteins):
    ADAM28    ADAMDEC1    ADAM7    ADAM22    ADAM9    ADAM12
    ADAM20

    Find genes that share paralogs with ADAM8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM8 (see all 568)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133245741,2
    C,F--135075432(+) CGGGGA/GGGGTG 3 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs31212961,2
    C,F--135075491(+) ttgccG/Aggaga 3 -- ds50012Minor allele frequency- A:0.50NA 4
    rs31212971,2
    C--135075676(+) GGGGCG/AGGGGT 3 -- ds50016Minor allele frequency- A:0.07WA NA CSA 245
    rs1388462501,2
    C--135075735(+) TCCTGC/GATCGG 3 -- ds50010--------
    rs1146122461,2
    F--135075787(+) GGGGAG/AGGCCT 3 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1402716211,2
    --135076118(+) GAATCC/TCATGG 3 -- ut310--------
    rs1848496341,2
    --135076121(+) TCCCAA/TGGGAA 3 -- ut310--------
    rs794536621,2
    C,F--135076139(+) CCAAGA/CTCAGG 3 -- ut311Minor allele frequency- C:0.03NA 120
    rs1899839751,2
    --135076175(+) GCAGTA/CTGCTC 3 -- ut310--------
    rs1815312661,2
    --135076424(+) TCCCAA/GCCTGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM8 (135075907 - 135090407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAM8 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv509381CNV Insertion20534489
    nsv896312CNV Loss21882294
    nsv832039CNV Loss17160897
    dgv884n71CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv896182CNV Loss21882294
    dgv856n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM8
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602267    OMIM disorders: --

    1 disease for ADAM8:    
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    asthma

    1 disease from the University of Copenhagen DISEASES database for ADAM8:
    Eosinophilic pneumonia

    Find genes that share disorders with ADAM8           About GenesLikeMe

    9 Novoseek inferred disease relationships for ADAM8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preterm delivery 30.2 6 16638589 (5)
    inflammation 26.8 11 17308171 (2), 16542157 (2), 18691140 (1), 12966612 (1) (see all 7)
    asthma 25.2 22 19397475 (6), 17339047 (4), 18691140 (3), 17088949 (1) (see all 5)
    neurodegeneration 22.1 7 11050116 (3), 16542157 (2)
    tumors 12.2 11 16772875 (3), 15538223 (1), 11050116 (1), 18710625 (1) (see all 6)
    cancer 7.12 1 17355265 (1)
    necrosis 6.51 1 11050116 (1)
    metastasis 5.77 4 15538223 (1), 18710625 (1), 14719095 (1), 20305301 (1)
    cancer lung 2.03 8 15623614 (7)

    Genetic Association Database (GAD): ADAM8
    Human Genome Epidemiology (HuGE) Navigator: ADAM8 (4 documents)

    Export disorders for ADAM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM8 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with ADAM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PubMed id 9126482)1, 2, 3, 9 Yoshiyama K.... Yamamoto S. (Genomics 1997)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study. (PubMed id 19575316)1, 4 Levula M....LehtimAoki T. (Ann. Med. 2009)
    4. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (PLoS ONE 2008)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation. (PubMed id 15574124)1, 2 Bartholin L.... Rimokh R. (Biol. Cell 2005)
    7. ADAM8 as a novel serological and histochemical marker for lung cancer. (PubMed id 15623614)1, 9 Ishikawa N....Nakamura Y. (Clin. Cancer Res. 2004)
    8. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. (PubMed id 18397961)1, 9 Ainola M....Konttinen Y.T. (Ann. Rheum. Dis. 2009)
    9. [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]. (PubMed id 18710625)1, 9 Wu G.C....Shi M.H. (Ai Zheng 2008)
    10. ADAM8: a new therapeutic target for asthma. (PubMed id 19397475)1, 9 Knolle M.D. and Owen C.A. (Expert Opin. Ther. Targets 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 101 HGNC: 215 AceView: ADAM8 Ensembl:ENSG00000151651 euGenes: HUgn101
    ECgene: ADAM8 H-InvDB: ADAM8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM8 gene:
    Search GeneIP for patents involving ADAM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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