Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM8 Gene

protein-coding   GIFtS: 62
GCID: GC10M135075

ADAM Metallopeptidase Domain 8

(Previous name: a disintegrin and metalloproteinase domain 8)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 81 2     Human Leukocyte Differentiation Antigen2
A Disintegrin And Metalloproteinase Domain 81 2     EC 3.4.24.-3
Cell Surface Antigen MS22 3     ADAM 83
MS22 3     CD156a Antigen3
CD1562 5     EC 3.4.248
Disintegrin And Metalloproteinase Domain-Containing Protein 82     

External Ids:    HGNC: 2151   Entrez Gene: 1012   Ensembl: ENSG000001516517   OMIM: 6022675   UniProtKB: P783253   

Export aliases for ADAM8 gene to outside databases

Previous GC identifers: GC10M133990 GC10M134205 GC10M134992 GC10M134549 GC10M134964 GC10M134925 GC10M128622


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM8 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during
neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2009)

GeneCards Summary for ADAM8 Gene: 
ADAM8 (ADAM metallopeptidase domain 8) is a protein-coding gene. Diseases associated with ADAM8 include eosinophilic pneumonia, and bacteriuria, and among its related super-pathways are Cell adhesion ECM remodeling. GO annotations related to this gene include metallopeptidase activity and calcium ion binding. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
Function: Possible involvement in extravasation of leukocytes

Gene Wiki entry for ADAM8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM8 gene promoter:
         Bach1   AML1a   Tal-1   Pax-2   IRF-1   Pax-2a   E47   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

ADAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135075:  view genomic region     (about GC identifiers)

Start:
135,075,907 bp from pter      End:
135,090,407 bp from pter
Size:
14,501 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 8 precursor  
Size: 824 amino acids; 88771 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with FST3
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ADAM8:
4DD8 (3D)    
Secondary accessions: B4DVM6 H0YL36 H0YLR0 H0YN39
Alternative splicing: 3 isoforms:  P78325-1   P78325-2   P78325-3   (No experimental confirmation available. Ref.4 (BC064500) sequence is in conflict in position: 693:A->S)

Explore the universe of human proteins at neXtProt for ADAM8: NX_P78325

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78325

  • 3 DME Specific Peptides for ADAM8 (P78325)
     LVGLEIW  MAHEMGH  GHNLGMDHD 

    ADAM8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001100.3  NP_001157961.1  NP_001157962.1  

    ENSEMBL proteins: 
     ENSP00000453302   ENSP00000453855   ENSP00000453043   ENSP00000452994   ENSP00000453735  

    Human Recombinant Protein Products for ADAM8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADAM8
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAM8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADAM8
    GenScript Custom Purified and Recombinant Proteins Services for ADAM8
    Sino Biological Recombinant Protein for ADAM8
    Sino Biological Cell Lysate for ADAM8 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM8 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA15220135
    GO:0005737cytoplasm IDA18397961
    GO:0005886plasma membrane IDA17548643
    GO:0005887integral to plasma membrane IDA18397961
    GO:0009986cell surface IDA17548643

    ADAM8 for ontologies           About GeneDecksing



    ADAM8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM8
    R&D Systems Antibodies for ADAM8
    OriGene Antibodies for ADAM8
    OriGene Custom Antibody Services for ADAM8
    GenScript Custom Superior Antibodies Services for ADAM8
    Novus Biologicals ADAM8 Antibodies
    Abcam antibodies for ADAM8
    Cloud-Clone Corp. Antibodies for ADAM8 
    ThermoFisher Antibodies for ADAM8
    LSBio Antibodies in human, mouse, rat for ADAM8 

    Assay Products for ADAM8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM8
    R&D Systems ELISAs for ADAM8         (see all)
    GenScript Custom Assay Services for ADAM8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAM8 
    Cloud-Clone Corp. CLIAs for ADAM8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM8 
    ADAM

    5/8 InterPro protein domains (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry P78325

    ProtoNet protein and cluster: P78325

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM8_HUMAN, P78325
    Function: Possible involvement in extravasation of leukocytes

         Genatlas biochemistry entry for ADAM8:
    a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen
    MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI12777399
    GO:0008237metallopeptidase activity IDA12777399
    GO:0008270zinc ion binding TAS18397961
         
    ADAM8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAM8:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adam8):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  normal 
     skeleton 

    ADAM8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam8tm1.1Rood for ADAM8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ADAM8:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidADAM8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAM8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAM8
    Sirion Biotech Customized adenovirus for overexpression of ADAM8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADAM8 (see all 15)
    OriGene ORF clones in mouse, rat for ADAM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADAM8 (NM_001164489)
    Sino Biological Human cDNA Clone for ADAM8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM8
    Sirion Biotech Customized lentivirus for stable overexpression of ADAM8 
                         Customized lentivirus expression plasmids for stable overexpression of ADAM8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAM8
    Search LifeMap BioReagents cell lines for ADAM8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAM8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    2Notch Signaling Pathway
    Notch Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADAM8
        Metalloproteases in connective tissue degradation


    1 Sino Biological Pathway for ADAM8 
        Notch Signaling Pathway



    ADAM8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM8

    2 Interacting proteins for ADAM8 (P783253) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FSTP198833I2D: score=1 
    FSTL3O956333I2D: score=1 
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ISS--
    GO:0001525angiogenesis ISS--
    GO:0002523leukocyte migration involved in inflammatory response ISS--
    GO:0002675positive regulation of acute inflammatory response ISS--
    GO:0002693positive regulation of cellular extravasation ----

    ADAM8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM8

    1 Novoseek inferred chemical compound relationship for ADAM8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 33.4 4 18691140 (1), 17270707 (1), 17339047 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAM8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAM8 gene (3 alternative transcripts): 
    NM_001109.4  NM_001164489.1  NM_001164490.1  

    Unigene Cluster for ADAM8:

    ADAM metallopeptidase domain 8
    Hs.501574  [show with all ESTs]
    Unigene Representative Sequence: NM_001109
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445355(uc021qbe.1 uc009ybi.3 uc010qva.2 uc009ybj.2)
    ENST00000415217 ENST00000485491 ENST00000559018 ENST00000468964 ENST00000561175
    ENST00000537099(uc010qvb.1) ENST00000560135 ENST00000463298 ENST00000486609
    ENST00000559180
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ADAM8:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidADAM8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAM8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM8
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM8 (see all 15)
    OriGene ORF clones in mouse, rat for ADAM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADAM8 (NM_001164489)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM8
    Sirion Biotech Customized lentivirus for stable overexpression of ADAM8 
                         Customized lentivirus expression plasmids for stable overexpression of ADAM8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM8

    Additional mRNA sequence: 

    AK301147.1 AK304324.1 AK310662.1 AK312834.1 BC064500.1 BC115404.1 D26579.1 

    5 DOTS entries:

    DT.211684  DT.101968108  DT.91662946  DT.95107243  DT.102824678 

    24/77 AceView cDNA sequences (see all 77):

    BQ687228 AA279188 BM875345 AI686614 BU579727 BF513621 AW450964 BQ007791 
    BQ582246 BM894152 AW296645 BM768375 BM768621 BQ689657 BM146234 AI814527 
    BE858211 AI240862 AA865449 BF062736 AI479652 BU787638 AW770687 NM_001109 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                          -     -     -                                                                                                                     
    SP4:                                                        -                                                                                                   
    SP5:                    -     -                                                                                                                                 

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
    SP1:                                -                           
    SP2:        -     -                 -                           
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for ADAM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTCAAGA
    ADAM8 Expression
    About this image


    Genevestigator expression for ADAM8

    SOURCE GeneReport for Unigene cluster: Hs.501574

    UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
    Tissue specificity: Expressed on neutrophils and monocytes

        SABiosciences Custom PCR Arrays for ADAM8
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM8 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam81 , 5 a disintegrin and metallopeptidase domain 81, 5 72.42(n)1
    65.08(a)1
      7 (84.96 cM)5
    115011  NM_007403.21  NP_031429.11 
     1399789325 
    chicken
    (Gallus gallus)
    Aves ADAM81 ADAM metallopeptidase domain 8 57.75(n)
    47.58(a)
      423672  XM_421552.3  XP_421552.3 
    zebrafish
    (Danio rerio)
    Actinopterygii adam8a1 a disintegrin and metalloproteinase domain 8a 49.46(n)
    42.26(a)
      368917  NM_200637.1  NP_956931.1 


    ENSEMBL Gene Tree for ADAM8 (if available)
    TreeFam Gene Tree for ADAM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM8 gene
    ADAM72  ADAM322  ADAM192  ADAM122  ADAM182  ADAM332  ADAM302  ADAM22  
    ADAM282  ADAM292  ADAM202  ADAM212  ADAM92  ADAM152  
    7 SIMAP similar genes for ADAM8 using alignment to 4 protein entries:     ADAM8_HUMAN (see all proteins):
    ADAM28    ADAMDEC1    ADAM7    ADAM22    ADAM9    ADAM12
    ADAM20

    ADAM8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/568 SNPs in ADAM8 are shown (see all 568)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133245741,2
    C,F--135075432(+) CGGGGA/GGGGTG 3 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs31212961,2
    C,F--135075491(+) ttgccG/Aggaga 3 -- ds50012Minor allele frequency- A:0.50NA 4
    rs31212971,2
    C--135075676(+) GGGGCG/AGGGGT 3 -- ds50016Minor allele frequency- A:0.07WA NA CSA 245
    rs1388462501,2
    C--135075735(+) TCCTGC/GATCGG 3 -- ds50010--------
    rs1146122461,2
    F--135075787(+) GGGGAG/AGGCCT 3 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1402716211,2
    --135076118(+) GAATCC/TCATGG 3 -- ut310--------
    rs1848496341,2
    --135076121(+) TCCCAA/TGGGAA 3 -- ut310--------
    rs794536621,2
    C,F--135076139(+) CCAAGA/CTCAGG 3 -- ut311Minor allele frequency- C:0.03NA 120
    rs1899839751,2
    --135076175(+) GCAGTA/CTGCTC 3 -- ut310--------
    rs1815312661,2
    --135076424(+) TCCCAA/GCCTGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM8 (135075907 - 135090407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for ADAM8 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv509381CNV Insertion20534489
    nsv896312CNV Loss21882294
    nsv832039CNV Loss17160897
    dgv884n71CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv896182CNV Loss21882294
    dgv856n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM8
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602267    OMIM disorders: --

    20/30 diseases for ADAM8 (see all 30):    About MalaCards
    eosinophilic pneumonia    bacteriuria    asthma    non-small cell lung carcinoma
    rabies    arteriosclerosis    viral hepatitis    pneumonia
    allergic rhinitis    rhinitis    myelodysplastic syndromes    fibrosarcoma
    hypoxia    myopathy    renal cell carcinoma    liver disease
    myocardial infarction    atherosclerosis    pancreatic cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for ADAM8:
    Eosinophilic pneumonia

    ADAM8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for ADAM8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preterm delivery 30.2 6 16638589 (5)
    inflammation 26.8 11 17308171 (2), 16542157 (2), 18691140 (1), 12966612 (1) (see all 7)
    asthma 25.2 22 19397475 (6), 17339047 (4), 18691140 (3), 17088949 (1) (see all 5)
    neurodegeneration 22.1 7 11050116 (3), 16542157 (2)
    tumors 12.2 11 16772875 (3), 15538223 (1), 11050116 (1), 18710625 (1) (see all 6)
    cancer 7.12 1 17355265 (1)
    necrosis 6.51 1 11050116 (1)
    metastasis 5.77 4 15538223 (1), 18710625 (1), 14719095 (1), 20305301 (1)
    cancer lung 2.03 8 15623614 (7)

    Genetic Association Database (GAD): ADAM8
    Human Genome Epidemiology (HuGE) Navigator: ADAM8 (4 documents)

    Export disorders for ADAM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM8 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with ADAM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PubMed id 9126482)1, 2, 3, 9 Yoshiyama K.... Yamamoto S. (1997)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study. (PubMed id 19575316)1, 4 Levula M....LehtimAoki T. (2009)
    4. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (2008)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    6. FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation. (PubMed id 15574124)1, 2 Bartholin L.... Rimokh R. (2005)
    7. ADAM8 as a novel serological and histochemical marker for lung cancer. (PubMed id 15623614)1, 9 Ishikawa N....Nakamura Y. (2004)
    8. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. (PubMed id 18397961)1, 9 Ainola M....Konttinen Y.T. (2009)
    9. [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] (PubMed id 18710625)1, 9 Wu G.C....Shi M.H. (2008)
    10. ADAM8: a new therapeutic target for asthma. (PubMed id 19397475)1, 9 Knolle M.D. and Owen C.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 101 HGNC: 215 AceView: ADAM8 Ensembl:ENSG00000151651 euGenes: HUgn101
    ECgene: ADAM8 H-InvDB: ADAM8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAM8 gene:
    Search GeneIP for patents involving ADAM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM8
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ADAM8 (ADAM8)   Browse Cell Culture Products  
     ELISAs for ADAM8 (ADAM8)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ADAM8 (ADAM8)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ADAM8 (ADAM8)  
     OriGene Antibodies for ADAM8   OriGene RNAi products in human, mouse, rat for ADAM8  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ADAM8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAM8  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAM8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAM8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAM8   OriGene Custom Protein Services for ADAM8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM8
     QIAGEN SeqTarget long-range PCR primers for resequencing ADAM8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM8
     GenScript Custom Purified and Recombinant Proteins Services for ADAM8 GenScript cDNA clones with any tag delivered in your preferred vector for ADAM8
     GenScript Custom Assay Services for ADAM8 GenScript Custom Superior Antibodies Services for ADAM8
     GenScript Custom overexpressing Cell Line Services for ADAM8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAM8 promoter
     Search Chromatin IP Primers for ADAM8
     RT2 qPCR Primer Assay in human, mouse, rat ADAM8
     Search GNC Networks for ADAM8
     SABiosciences Custom PCR Arrays for ADAM8
     Search Tocris compounds for ADAM8
     Proteins and Antibodies for ADAM8
     Cell Lysates for ADAM8
     cDNA Clones for ADAM8
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAM8 antibodies
     Antibodies for ADAM8
     See all of Abcam's Antibodies, Kits and Proteins for ADAM8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADAM8
     Antibodies for ADAM8
     ELISAs for ADAM8
     CLIAs for ADAM8
     Search LifeMap BioReagents cell lines for ADAM8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM8
     SwitchGear 3'UTR luciferase reporter plasmids for ADAM8
     SwitchGear Promoter luciferase reporter plasmids for ADAM8
     ThermoFisher Antibodies for ADAM8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM8
    Customized:
     lentivirus for stable overexpression of ADAM8
     lentivirus expression plasmids for stable overexpression of ADAM8
     adenovirus for overexpression of ADAM8
     LSBio Antibodies in human, mouse, rat for ADAM8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAM8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4