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ADAM8 Gene

protein-coding GIFtS: 62

GC10M134964

ADAM metallopeptidase domain 8
(Previous name: a disintegrin and metalloproteinase domain 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CD156 ^¹, ², ⁵
EC 3.4.24.- ^³
MGC134985 ^²
MS2 ^¹, ², ³
OTTHUMP00000020792 ^²

Descriptions
ADAM 8 ^³
ADAM metallopeptidase domain 8 ^²
CD156a antigen ^², ³
Cell surface antigen MS2 ^², ³
a disintegrin and metalloproteinase domain 8 ^¹, ²

External Ids
HGNC: 215¹
Entrez Gene: 101²
UniProtKB: P78325³
Ensembl: ENSG00000151651⁷

Search outside databases for aliases for ADAM8 gene

Previous GC identifers: GC10M133990 GC10M134205 GC10M134992 GC10M134549

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADAM8:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members

of this family are membrane-anchored proteins structurally related to snake venom disintegrins,

and have been implicated in a variety of biological processes involving cell-cell and cell-matrix

interactions, including fertilization, muscle development, and neurogenesis. The protein encoded

by this gene may be involved in cell adhesion during neurodegeneration. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Function: Possible involvement in extravasation of leukocytes

Gene Wiki entry for ADAM8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM8 gene

Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3

ADAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M134964: (about GC identifiers)

Start:	134,925,911 bp from pter
End:	134,940,362 bp from pter
Size:	14,452 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_017795.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 8 precursor

Size: 824 amino acids; 88673 Da

Cofactor: Binds 1 zinc ion per subunit (Probable)

Subcellular location: Membrane; Single-pass type I membrane protein

REFSEQ proteins: NP_001100.2

ENSEMBL proteins:

ENSP00000357554

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAM8
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM8)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9126482

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Antibodies for ADAM8:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM8
	Sigma-Aldrich Antibodies for ADAM8
	R&D Systems Antibodies for ADAM8
	Antibodies from Abcam (ADAM8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM8)
	Novus Biologicals Antibodies for ADAM8

Assays for ADAM8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ADAM8 (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P78325

ProtoNet protein and cluster: P78325

3 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001109

Applied Biosystems Silencer® siRNAs for ADAM8

Sigma-Aldrich siRNA and siRNA Panels for ADAM8

Sigma-Aldrich shRNA Panels and shRNA for ADAM8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001109
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001109
untagged cDNA clone in CMV expression vector: NM_001109

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001109

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Function: Possible involvement in extravasation of leukocytes

Enzyme Number (IUBMB): EC 3.4.24.-

Genatlas biochemistry entry for ADAM8:

a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein

(antigen MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix

interactions

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adam8):

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM8 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks ADAM8 for the pathways selected above

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0016337	cell-cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM8

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM8
1 Novoseek chemical compound relationship for ADAM8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
allergens	34.94	4	18691140 (1), 17270707 (1), 17339047 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001109

Sigma-Aldrich siRNA and siRNA Panels for ADAM8

Sigma-Aldrich shRNA Panels and shRNA for ADAM8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001109

REFSEQ mRNAs for ADAM8 gene:

NM_001109.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001109

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001109
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001109
                                 untagged cDNA clone in CMV expression vector: NM_001109

Additional cDNA sequence:

AK301147.1 AK304324.1 AK310662.1 AK312834.1 BC064500.1 BC115404.1 D26579.1

5 DOTS entries:

DT.211684 DT.101968108 DT.91662946 DT.95107243 DT.102824678

24/77 AceView cDNA sequences (see all 77 ):

AW450964 BQ582246 BF513621 AI686614 AA279188 BU579727 BM894152 AW296645

BQ007791 BM875345 BQ687228 AI479652 AI814527 D26579 BF062736 NM_001109

AI240862 BM146234 BU542259 BM850301 AW770687 AA865449 BQ708311 BF512208

highest scoring ESTs for ADAM8:

D26579 BC064500 BE243136 BI768819 BI907784 BM146234 BM146278 BM146783 BM837639 BQ689657

Unigene Cluster for ADAM8:

ADAM metallopeptidase domain 8

Hs.501574 [show with all ESTs]

Unigene Representative Sequence: NM_001109

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^
SP1:
SP2:
SP3:									-		-		-
SP4:																			-
SP5:							-		-

ExUns:	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	·	23c
SP1:											-
SP2:			-		-						-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ADAM8

1 Ensembl transcript including schematic representation:

ENST00000368566

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADAM8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM8

¹ / ² / ³

5 probe-sets matching ADAM8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40712_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D26579	1.00	1.00	1.00	1
205180_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001109	0.60	1.00	0.82	1
205179_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI814527	0.60	1.00	0.82	1
205180_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205179_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADAM8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGATTCAAGA

SOURCE GeneReport for Unigene cluster: Hs.501574
Expression variation in blood from EXPOLDB for ADAM8
UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325
Tissue specificity: Expressed on neutrophils and monocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM8 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAM8¹	--	ADAM metallopeptidase domain 8	74.52(n) 64.54(a)	491699 XM_548820.2 XP_548820.2
cow (Bos taurus)	ADAM8¹	--	ADAM metallopeptidase domain 8	75.9(n) 67.24(a)	519652 XM_597877.3 XP_597877.3
rat (Rattus norvegicus)	Adam8¹	--	ADAM metallopeptidase domain 8	72.91(n) 66.27(a)	499285 XM_574584.2 XP_574584.2
mouse (Mus musculus)	Adam8^{1, 5}	7⁵	a disintegrin and metallopeptidase domain 8^{1, 5}	72.42(n)¹ 65.08(a)¹	11501¹ NM_007403.2¹ NP_031429.1¹ AK089086⁵ AK089169⁵ (see all 21)
chicken (Gallus gallus)	ADAM8¹	--	ADAM metallopeptidase domain 8	56.69(n) 47.45(a)	423672 XM_421552.2 XP_421552.2

About this table Species with no ortholog for ADAM8

ENSEMBL Gene Tree for ADAM8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM8 gene

ADAM7² ADAMDEC1² ADAM28²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/129 NCBI SNPs in ADAM8 are shown (see all 129 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 85)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1573041^1,2	A,C,F,H,O	134941792(+)	`GCCGAC/TGCTGA`	1	--	ng3¹		4		EU EA WA	418
	rs2275720^1,2	A,C,F,H	134932336(-)	`CCGTCC/TTCGTG`	1	F/L	mis¹		7		EA WA	2050
	rs2995300^1,2	A,C,F,H	134926514(+)	`GCATTA/CCTGAG`	1	--	ut3¹ ese³		5		EU EA WA	1904
	rs2275718^1,2	A,C,F	134942231(+)	`CTCGGC/TGGTGC`	1	--	ng3¹		1		EA	1494
	rs2275725^1,2	C,F,H	134939025(+)	`ACGCCG/ACGGCA`	1	R/W	mis¹ ese³		9		EA EU WA	1746
	rs11101676^1,2	A,C	134941230(+)	`GGGGGC/GCCTCA`	1	--	ng3¹ tfbs³ trp³		0	--	--	--	--
	rs1005805^1,2	A,F	134942090(-)	`CGGACC/TGGTGA`	1	--	ng3¹		4		EA NA	160
--	rs3008327^1,2	A,C	134941386(+)	`GGCCGC/GGGCCT`	1	--	ng3¹		0	--	--	--	--
	rs1005806^1,2	A	134941971(-)	`GGTGAC/TAGGAG`	1	--	ng3¹		0	--	--	--	--
--	rs3216040^1,2	C	134942273(+)	`CCACA-/ACCCTT`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ADAM8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602267

9 Novoseek disease relationships for ADAM8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
preterm delivery	31.82	6	16638589 (5)
asthma	26.81	22	19397475 (6), 17339047 (4), 18691140 (3), 17088949 (1) (see all 5)
inflammation	24.79	10	17308171 (2), 16542157 (2), 18691140 (1), 12966612 (1) (see all 6)
neurodegeneration	24.51	7	11050116 (3), 16542157 (2)
tumors	10.22	9	16772875 (3), 15538223 (1), 11050116 (1), 18710625 (1) (see all 5)
necrosis	8.16	1	11050116 (1)
cancer lung	4.01	8	15623614 (7)
cancer	3.80	1	17355265 (1)
metastasis	0.00	3	15538223 (1), 18710625 (1), 14719095 (1)

About this table

Human Genome Epidemiology Navigator: ADAM8 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/36 PubMed articles for ADAM8 gene (see all 36 ):

CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PubMed id 9126482)^{1, 2, 3, 4} Yoshiyama K.... Yamamoto S. (1997)
ADAM8 as a novel serological and histochemical marker for lung cancer. (PubMed id 15623614)^{1, 3} Ishikawa N....Nakamura Y. (2004)
Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration. (PubMed id 11050116)^{1, 3} Schlomann U....Bartsch J.W. (2000)
ADAM8 in allergy. (PubMed id 18691140)^{1, 3} Matsuno O....Higuchi Y. (2008)
Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. (PubMed id 19284887)^{1, 3} Ma G.F....Konttinen Y.T. (2009)
Increased expression of ADAM33 and ADAM8 with disease progression in asthma. (PubMed id 17339047)^{1, 3} Foley S.C....Hamid Q. (2007)
Hypoxia-dependent expression of ADAM8 in human pancreatic cancer cell lines. (PubMed id 18566576)³ Valkovskaya N.V. (2008)
Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)³ Tremblay K....Laprise C. (2008)
ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer. (PubMed id 17979891)³ Valkovskaya N....Kleeff J. (2007)
Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. (PubMed id 17548643)³ Gomez-Gaviro M....Diaz-Gonzalez F. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 101	HGNC: 215	AceView: ADAM8	Ensembl:ENSG00000151651	euGenes: HUgn101
ECgene: ADAM8	H-InvDB: ADAM8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADAM8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADAM8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM8		Antibodies for ADAM8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for ADAM8

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ADAM8 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ADAM8

Summaries
for ADAM8

Genomic Location
for ADAM8

Proteins
for ADAM8

Protein Domains/
Families
for ADAM8

Gene Function
for ADAM8

Pathways & Interactions
for ADAM8

Drugs & Compounds
for ADAM8

Transcripts
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Expression
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Genome Databases showing ADAM8

Other Databases showing ADAM8

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Licensable Technologies
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM8 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ADAM8

Summariesfor ADAM8

Genomic Locationfor ADAM8

Proteinsfor ADAM8

Protein Domains/Familiesfor ADAM8

Gene Functionfor ADAM8

Pathways & Interactionsfor ADAM8

Drugs & Compoundsfor ADAM8

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Genome Databases showing ADAM8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM8

Summaries
for ADAM8

Genomic Location
for ADAM8

Proteins
for ADAM8

Protein Domains/
Families
for ADAM8

Gene Function
for ADAM8

Pathways & Interactions
for ADAM8

Drugs & Compounds
for ADAM8

Transcripts
for ADAM8

Expression
for ADAM8

Orthologs
for ADAM8

Paralogs
for ADAM8

SNPs/Variants
for ADAM8

Disorders & Mutations
for ADAM8

Medical News
for ADAM8

Publications
for ADAM8

Licensable Technologies
for ADAM8

Services
for ADAM8