Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAM8 Gene

Aliases for ADAM8 Gene

  • ADAM Metallopeptidase Domain 8 2 3 5
  • A Disintegrin And Metalloproteinase Domain 8 2 3
  • Cell Surface Antigen MS2 3 4
  • MS2 3 4
  • Human Leukocyte Differentiation Antigen 3
  • CD156a Antigen 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • CD156a 3
  • ADAM 8 4
  • CD156 3

External Ids for ADAM8 Gene

Previous GeneCards Identifiers for ADAM8 Gene

  • GC10M133990
  • GC10M134205
  • GC10M134992
  • GC10M134549
  • GC10M134964
  • GC10M134925
  • GC10M135075
  • GC10M128622

Summaries for ADAM8 Gene

Entrez Gene Summary for ADAM8 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

GeneCards Summary for ADAM8 Gene

ADAM8 (ADAM Metallopeptidase Domain 8) is a Protein Coding gene. Diseases associated with ADAM8 include asthma. Among its related pathways are Degradation of the extracellular matrix and Notch Signaling Pathway (sino). GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM8 Gene

  • Possible involvement in extravasation of leukocytes.

Gene Wiki entry for ADAM8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM8 Gene

Genomics for ADAM8 Gene

Regulatory Elements for ADAM8 Gene

Promoters for ADAM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM8 Gene

Chromosome:
10
Start:
133,262,403 bp from pter
End:
133,276,903 bp from pter
Size:
14,501 bases
Orientation:
Minus strand

Genomic View for ADAM8 Gene

Genes around ADAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM8 Gene

Proteins for ADAM8 Gene

  • Protein details for ADAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78325-ADAM8_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 8
    Protein Accession:
    P78325
    Secondary Accessions:
    • B4DVM6
    • H0YL36
    • H0YLR0
    • H0YN39

    Protein attributes for ADAM8 Gene

    Size:
    824 amino acids
    Molecular mass:
    88771 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with FST3.

    Three dimensional structures from OCA and Proteopedia for ADAM8 Gene

    Alternative splice isoforms for ADAM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM8 Gene

Proteomics data for ADAM8 Gene at MOPED

Selected DME Specific Peptides for ADAM8 Gene

Post-translational modifications for ADAM8 Gene

  • Glycosylation at Asn 67, Asn 91, Asn 436, and Asn 612
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM8 Gene

Antibody Products

Domains & Families for ADAM8 Gene

Gene Families for ADAM8 Gene

Graphical View of Domain Structure for InterPro Entry

P78325

UniProtKB/Swiss-Prot:

ADAM8_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM8: view

Function for ADAM8 Gene

Molecular function for ADAM8 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions
UniProtKB/Swiss-Prot Function:
Possible involvement in extravasation of leukocytes.

Enzyme Numbers (IUBMB) for ADAM8 Gene

Gene Ontology (GO) - Molecular Function for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0043621 protein self-association TAS 12777399
genes like me logo Genes that share ontologies with ADAM8: view
genes like me logo Genes that share phenotypes with ADAM8: view

Animal Models for ADAM8 Gene

MGI Knock Outs for ADAM8:

Animal Model Products

miRNA for ADAM8 Gene

miRTarBase miRNAs that target ADAM8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM8 Gene

Localization for ADAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM8 Gene COMPARTMENTS Subcellular localization image for ADAM8 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
lysosome 4
vacuole 4
extracellular 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18397961
GO:0042581 specific granule IDA 17548643
genes like me logo Genes that share ontologies with ADAM8: view

Pathways & Interactions for ADAM8 Gene

genes like me logo Genes that share pathways with ADAM8: view

Pathways by source for ADAM8 Gene

1 Sino Biological pathway for ADAM8 Gene

Gene Ontology (GO) - Biological Process for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006954 inflammatory response IDA 17548643
GO:0010954 positive regulation of protein processing NAS 17548643
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with ADAM8: view

No data available for SIGNOR curated interactions for ADAM8 Gene

Drugs & Compounds for ADAM8 Gene

(1) Additional Compounds for ADAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM8: view

Transcripts for ADAM8 Gene

Unigene Clusters for ADAM8 Gene

ADAM metallopeptidase domain 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
SP1:
SP2:
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ADAM8 Gene

GeneLoc Exon Structure for
ADAM8
ECgene alternative splicing isoforms for
ADAM8

Expression for ADAM8 Gene

mRNA expression in normal human tissues for ADAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM8 Gene

This gene is overexpressed in Whole Blood (x34.0).

Protein differential expression in normal tissues from HIPED for ADAM8 Gene

This gene is overexpressed in NK cells (37.1), Peripheral blood mononuclear cells (23.7), and CD8 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM8 Gene



SOURCE GeneReport for Unigene cluster for ADAM8 Gene Hs.501574

mRNA Expression by UniProt/SwissProt for ADAM8 Gene

P78325-ADAM8_HUMAN
Tissue specificity: Expressed on neutrophils and monocytes.
genes like me logo Genes that share expression patterns with ADAM8: view

Protein tissue co-expression partners for ADAM8 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADAM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM8 35
  • 75.92 (n)
  • 67.3 (a)
ADAM8 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam8 35
  • 72.3 (n)
  • 65.08 (a)
Adam8 16
Adam8 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM8 35
  • 95.86 (n)
  • 94.44 (a)
rat
(Rattus norvegicus)
Mammalia Adam8 35
  • 72.43 (n)
  • 65.79 (a)
dog
(Canis familiaris)
Mammalia ADAM8 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM8 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ADAM8 35
  • 57.81 (n)
  • 48.65 (a)
ADAM8 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adam8b 35
  • 49.47 (n)
  • 42.48 (a)
adam8a 36
  • 38 (a)
OneToMany
adam8b 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ADAM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAM8 Gene

ENSEMBL:
Gene Tree for ADAM8 (if available)
TreeFam:
Gene Tree for ADAM8 (if available)

Paralogs for ADAM8 Gene

(7) SIMAP similar genes for ADAM8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ADAM8: view

Variants for ADAM8 Gene

Sequence variations from dbSNP and Humsavar for ADAM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11101675 - 133,273,956(+) CTGCC(C/T)GCGAG reference, missense
rs45451297 - 133,273,262(+) GGGCC(A/G)AGGCC reference, missense
rs12257830 - 133,271,277(+) GCAGC(A/G)GTTCC reference, missense
rs3008319 - 133,263,761(+) GCTTG(A/G)TGACC intron-variant, reference, synonymous-codon, missense
rs2275725 - 133,275,531(+) ACGCC(A/G)CGGCA intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAM8 Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv832038 CNV Gain+Loss 17160897
dgv878n71 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
dgv883n71 CNV Loss 21882294
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294
nsv516968 CNV Loss 19592680
dgv886n71 CNV Gain 21882294
nsv896301 CNV Gain 21882294
dgv887n71 CNV Gain 21882294
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
nsv509381 CNV Insertion 20534489
dgv888n71 CNV Loss 21882294
dgv122n27 CNV Loss 19166990
nsv896310 CNV Loss 21882294
dgv3e196 CNV Duplication 17116639
nsv896312 CNV Loss 21882294
esv2750853 CNV Gain 17911159

Variation tolerance for ADAM8 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM8 Gene

HapMap Linkage Disequilibrium report
ADAM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM8 Gene

Disorders for ADAM8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search ADAM8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADAM8

Genetic Association Database (GAD)
ADAM8
Human Genome Epidemiology (HuGE) Navigator
ADAM8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM8
genes like me logo Genes that share disorders with ADAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM8 Gene

Publications for ADAM8 Gene

  1. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PMID: 9126482) Yoshiyama K. … Yamamoto S. (Genomics 1997) 2 3 4 23 67
  2. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. (PMID: 18397961) Ainola M. … Konttinen Y.T. (Ann. Rheum. Dis. 2009) 3 23
  3. Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity. (PMID: 18811590) Hall T. … Zack M.D. (Biosci. Rep. 2009) 3 23
  4. Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. (PMID: 19284887) Ma G.F. … Konttinen Y.T. (BMC Microbiol. 2009) 3 23
  5. ADAM8: a new therapeutic target for asthma. (PMID: 19397475) Knolle M.D. … Owen C.A. (Expert Opin. Ther. Targets 2009) 3 23

Products for ADAM8 Gene

Sources for ADAM8 Gene

Back to Top

Content