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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAM8 Gene

protein-coding GIFtS: 60
GCID: GC10M135075

ADAM metallopeptidase domain 8

(Previous name: a disintegrin and metalloproteinase domain 8 )

Explore 31 diseases affiliated with
ADAM8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 8¹ ²		Human Leukocyte Differentiation Antigen²
MS2¹ ² ³		EC 3.4.24.-³
CD156¹ ² ⁵		ADAM 8³
A Disintegrin And Metalloproteinase Domain 8¹ ²		CD156a Antigen³
Cell Surface Antigen MS2² ³		EC 3.4.24⁸
Disintegrin And Metalloproteinase Domain-Containing Protein 8²

External Ids:	HGNC: 215¹	Entrez Gene: 101²	Ensembl: ENSG00000151651⁷	OMIM: 602267⁵	UniProtKB: P78325³

Export aliases for ADAM8 gene to outside databases

Previous GC identifers: GC10M133990 GC10M134205 GC10M134992 GC10M134549 GC10M134964 GC10M134925 GC10M128622

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM8:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are

membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of

biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,

and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it

is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in

multiple transcript variants. (provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Function: Possible involvement in extravasation of leukocytes

Gene Wiki entry for ADAM8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008818.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAM8 gene promoter:
Bach1 AML1a Tal-1 Pax-2 IRF-1 Pax-2a E47 AREB6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM8 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAM8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3

ADAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM8 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M135075: view genomic region (about GC identifiers)

Start:	135,075,907 bp from pter	End:	135,090,407 bp from pter
Size:	14,501 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 8 precursor

Size: 824 amino acids; 88771 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with FST3

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for ADAM8:

4DD8 (3D)

Secondary accessions: B4DVM6 H0YL36 H0YLR0 H0YN39

Alternative splicing: 3 isoforms: P78325-1 P78325-2 P78325-3 (No experimental confirmation available. Ref.4 (BC064500) sequence is in conflict in position: 693:A->S)

Explore the universe of human proteins at neXtProt for ADAM8: NX_P78325

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78325

3 DME Specific Peptides for ADAM8 (P78325)

LVGLEIW

MAHEMGH

GHNLGMDHD

ADAM8 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (3 alternative transcripts):

NP_001100.3 NP_001157961.1 NP_001157962.1

ENSEMBL proteins:

ENSP00000453302 ENSP00000453855 ENSP00000453043 ENSP00000452994 ENSP00000453735

Human Recombinant Protein Products for ADAM8:

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	Uscn Proteins for ADAM8

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002102	podosome	IDA	15220135
GO:0005737	cytoplasm	IDA	18397961
GO:0005886	plasma membrane	IDA	17548643
GO:0005887	integral to plasma membrane	IDA	18397961
GO:0009986	cell surface	IDA	17548643

ADAM8 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ADAM8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAM8 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR018358 Disintegrin_CS

IPR024079 MetalloPept_cat_dom

IPR001762 Blood-coag_inhib_Disintegrin

IPR006586 ADAM_Cys-rich

IPR000742 EG-like_dom

Graphical View of Domain Structure for InterPro Entry P78325

ProtoNet protein and cluster: P78325

3 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADAM8_HUMAN, P78325

Function: Possible involvement in extravasation of leukocytes

Genatlas biochemistry entry for ADAM8:

a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen

MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions

Enzyme Numbers (IUBMB): EC 3.4.24.-¹ EC 3.4.24²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	ISS	--
GO:0005515	protein binding	IPI	12777399
GO:0008237	metallopeptidase activity	IDA	12777399
GO:0008270	zinc ion binding	TAS	18397961

ADAM8 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADAM8:

Increased gamma-H2AX phosphory

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adam8):

cellular	hematopoietic system	homeostasis/metabolism	immune system	normal
skeleton

ADAM8 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adam8^tm1.1Rood for ADAM8

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM8

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ADAM8 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ADAM8:
		hsa-miR-544b
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADAM8

Metalloproteases in connective tissue degradation

ADAM8 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAM8

2 Interacting proteins for ADAM8 (P78325³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FST	P19883³	I2D: score=1
FSTL3	O95633³	I2D: score=1

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	ISS	--
GO:0001525	angiogenesis	ISS	--
GO:0002523	leukocyte migration involved in inflammatory response	ISS	--
GO:0002675	positive regulation of acute inflammatory response	ISS	--
GO:0002693	positive regulation of cellular extravasation	--	--

ADAM8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADAM8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAM8
1 Novoseek chemical compound relationship for ADAM8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
allergens	33.4	4	18691140 (1), 17270707 (1), 17339047 (1)

Search CenterWatch for drugs/clinical trials and news about ADAM8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAM8 gene (3 alternative transcripts):

NM_001109.4 NM_001164489.1 NM_001164490.1

Unigene Cluster for ADAM8:

ADAM metallopeptidase domain 8

Hs.501574 [show with all ESTs]

Unigene Representative Sequence: NM_001109

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000445355(uc021qbe.1 uc009ybi.3 uc010qva.2 uc009ybj.2)

ENST00000415217 ENST00000485491 ENST00000559018 ENST00000468964 ENST00000561175

ENST00000537099(uc010qvb.1) ENST00000560135 ENST00000463298 ENST00000486609

ENST00000559180

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ADAM8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM8
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ADAM8:
		hsa-miR-544b
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Additional cDNA sequence:

AK301147.1 AK304324.1 AK310662.1 AK312834.1 BC064500.1 BC115404.1 D26579.1

5 DOTS entries:

DT.211684 DT.101968108 DT.91662946 DT.95107243 DT.102824678

24/77 AceView cDNA sequences (see all 77):

BU579727 AW296645 BM894152 AW450964 BQ687228 AI686614 AA279188 BQ582246

BF513621 BM875345 BQ007791 BC064500 BG231530 BF062736 BQ689657 BQ708311

BM850301 BM843289 AA865449 BI518556 BM837639 BM768621 BU787638 BE858211

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^
SP1:
SP2:
SP3:									-		-		-
SP4:																			-
SP5:							-		-

ExUns:	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	·	23c
SP1:											-
SP2:			-		-						-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ADAM8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAM8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATTCAAGA

About this image
Genevestigator expression for ADAM8

SOURCE GeneReport for Unigene cluster: Hs.501574

UniProtKB/Swiss-Prot: ADAM8_HUMAN, P78325

Tissue specificity: Expressed on neutrophils and monocytes

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADAM8 gene from 2/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADAM8¹	ADAM metallopeptidase domain 8	57.75(n) 47.58(a)		423672 XM_421552.3 XP_421552.3
zebrafish (Danio rerio)	Actinopterygii	adam8a¹	a disintegrin and metalloproteinase domain 8a	49.46(n) 42.26(a)		368917 NM_200637.1 NP_956931.1

ENSEMBL Gene Tree for ADAM8 (if available)
TreeFam Gene Tree for ADAM8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAM8 gene

ADAM7² ADAM19² ADAM12² ADAM23² ADAM33² ADAM11² ADAM30² ADAM22²

ADAM28² ADAM29² ADAM20² ADAM9² ADAM21² ADAM15²

10 SIMAP similar genes for ADAM8 using alignment to 4 protein entries: ADAM8_HUMAN (see all proteins):

ADAM28 ADAMDEC1 ADAM7 ADAM22 ADAM9 ADAM12

ADAM20 ADAM30 ADAM19 ADAM21

ADAM8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113324574^1,2		--	135075432(+)	`CGGGGA/GGGGTG`	3	--	ds500¹		1		CSA	1
rs3121296^1,2	C,F	--	135075491(+)	`ttgccG/Aggaga`	3	--	ds500¹		2		NA	4
rs3121297^1,2	C	--	135075676(+)	`GGGGCG/AGGGGT`	3	--	ds500¹		6		WA NA CSA	245
rs138846250^1,2		--	135075735(+)	`TCCTGC/GATCGG`	3	--	ds500¹		0	--	--	--	--
rs114612246^1,2	F	--	135075787(+)	`GGGGAG/AGGCCT`	3	--	ds500¹		1		WA	118
rs140271621^1,2		--	135076118(+)	`GAATCC/TCATGG`	3	--	ut3¹		0	--	--	--	--
rs184849634^1,2		--	135076121(+)	`TCCCAA/TGGGAA`	3	--	ut3¹		0	--	--	--	--
rs79453662^1,2	C,F	--	135076139(+)	`CCAAGA/CTCAGG`	3	--	ut3¹		1		NA	120
rs189983975^1,2		--	135076175(+)	`GCAGTA/CTGCTC`	3	--	ut3¹		0	--	--	--	--
rs181531266^1,2		--	135076424(+)	`TCCCAA/GCCTGG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADAM8 (135075907 - 135090407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for ADAM8
14 CNVs: 29878 2896 29877 4723 5270 4721 8673 5272 29879 4722 5273 5271 53744 3829

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM8

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAM8 for disorders           About GeneDecksing

OMIM gene information: 602267    OMIM disorders: --

20/31 diseases for ADAM8 (see all 31):    About MalaCards

neurodegeneration asthma non-small cell lung carcinoma eosinophilic pneumonia

allergic rhinitis bacteriuria viral hepatitis myocardial infarction

rhinitis renal cell carcinoma arteriosclerosis myelodysplastic syndrome

myopathy lung carcinoma rabies fibrosarcoma

liver disease alzheimer's disease ovarian cancer pancreatic cancer

1 disease from the University of Copenhagen DISEASES database for ADAM8:

Eosinophilic pneumonia

9 Novoseek disease relationships for ADAM8 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
preterm delivery	30.2	6	16638589 (5)
inflammation	26.8	11	17308171 (2), 16542157 (2), 18691140 (1), 12966612 (1) (see all 7)
asthma	25.2	22	19397475 (6), 17339047 (4), 18691140 (3), 17088949 (1) (see all 5)
neurodegeneration	22.1	7	11050116 (3), 16542157 (2)
tumors	12.2	11	16772875 (3), 15538223 (1), 11050116 (1), 18710625 (1) (see all 6)
cancer	7.12	1	17355265 (1)
necrosis	6.51	1	11050116 (1)
metastasis	5.77	4	15538223 (1), 18710625 (1), 14719095 (1), 20305301 (1)
cancer lung	2.03	8	15623614 (7)

Human Genome Epidemiology (HuGE) Navigator: ADAM8 (4 documents)

Export disorders for ADAM8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADAM8 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with ADAM8)

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CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PubMed id 9126482)^{1, 2, 3, 9} Yoshiyama K.... Yamamoto S. (1997)
FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation. (PubMed id 15574124)^{1, 2} Bartholin L.... Rimokh R. (2005)
ADAM8 as a novel serological and histochemical marker for lung cancer. (PubMed id 15623614)^{1, 9} Ishikawa N....Nakamura Y. (2004)
Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. (PubMed id 18397961)^{1, 9} Ainola M....Konttinen Y.T. (2009)
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] (PubMed id 18710625)^{1, 9} Wu G.C....Shi M.H. (2008)
ADAM8: a new therapeutic target for asthma. (PubMed id 19397475)^{1, 9} Knolle M.D. and Owen C.A. (2009)
Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity. (PubMed id 18811590)^{1, 9} Hall T....Zack M.D. (2009)
ADAM8 in allergy. (PubMed id 18691140)^{1, 9} Matsuno O....Higuchi Y. (2008)
Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. (PubMed id 19284887)^{1, 9} Ma G.F....Konttinen Y.T. (2009)
Increased expression of ADAM33 and ADAM8 with disease progression in asthma. (PubMed id 17339047)^{1, 9} Foley S.C....Hamid Q. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 101	HGNC: 215	AceView: ADAM8	Ensembl:ENSG00000151651	euGenes: HUgn101
ECgene: ADAM8	H-InvDB: ADAM8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADAM8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAM8 gene
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