ADAM7 Gene
protein-coding GIFtS: 48
GCID: GC08P024354
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ADAM metallopeptidase domain 7(Previous name: a disintegrin and metalloproteinase domain 7 )
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Aliases
for ADAM7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 71 2 | | GP832 3 | | EAPI1 2 | | ADAM 72 3 | | GP-831 2 | | ADAM-72 | | A Disintegrin And Metalloproteinase Domain 71 2 | | Disintegrin And Metalloproteinase Domain-Containing Protein 72 | | Sperm Maturation-Related Glycoprotein GP-832 3 | | Epididymal Apical Protein I2 |
Export aliases for ADAM7 gene to outside databasesPrevious GC identifers: GC08P024031 GC08P024652 GC08P024321 GC08P024322 GC08P022843 |
Summaries
for ADAM7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM7:
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multipleprocesses including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may playroles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this genemay be involved in the progression of melanoma. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9Function: May play an important role in male reproduction including sperm maturation and gonadotrope function. This isa non catalytic metalloprotease-like protein (By similarity)
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Genomic Views
for ADAM7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM7 gene promoter:
C/EBPbeta Pax-2 Pax-2a CUTL1 YY1 MEF-2A IRF-2 Pax-2b aMEF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2ADAM7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P024354: view genomic region
(about GC identifiers)
Start:
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24,298,443 bp from pter |
End:
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24,384,483 bp from pter |
Size:
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86,041 bases |
Orientation:
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plus strand |
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Proteins
for ADAM7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 7 precursor Size: 754 amino acids; 85669 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A8K8X7 O75959Explore the universe of human proteins at neXtProt for ADAM7: NX_Q9H2U9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H2U9
ADAM7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003808.2
ENSEMBL proteins: ENSP00000393073 ENSP00000175238 ENSP00000370166 ENSP00000430400
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ADAM7 for ontologies About GeneDecksing
ADAM7 Antibody Products:
Assay Products for ADAM7: |
Protein
Domains /
Families
for ADAM7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM7 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9H2U9ProtoNet protein and cluster: Q9H2U9 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9Similarity: Contains 1 disintegrin domainSimilarity: Contains 1 peptidase M12B domain |
Function
for ADAM7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9Function: May play an important role in male reproduction including sperm maturation and gonadotrope function. This isa non catalytic metalloprotease-like protein (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM7 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004175 | endopeptidase activity |
-- | -- | | GO:0004222 | metalloendopeptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ADAM7 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADAM7:
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Pathways & Interactions
for ADAM7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM7
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
ADAM7 for ontologies About GeneDecksing
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Drugs & Compounds
for ADAM7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAM7
Search CenterWatch for drugs/clinical trials and news about ADAM7
|
Transcripts
for ADAM7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAM7 gene: NM_003817.3 Unigene Cluster for ADAM7: ADAM metallopeptidase domain 7 Hs.116147 [show with all ESTs]Unigene Representative Sequence: NM_0038174 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441335(uc003xea.1) ENST00000175238(uc003xeb.3) ENST00000380789
ENST00000520720(uc003xec.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAM7 (NM_003817) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM7 |
Additional cDNA sequence: AF090327.1 AF215824.1 AK292492.1 BC043207.2 BC058037.1 4 DOTS entries: DT.92414785 DT.208020 DT.99959504 DT.91988055 12 AceView cDNA sequences: BC043207 NM_003817 BG718002 AI699458 BU569298 BC058037 BU570785 BI559778 AF090327 AF215824 BX109205 AL705011
GeneLoc Exon Structure
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Expression
for ADAM7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAGGTCT
About this image
See ADAM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM7
SOURCE GeneReport for Unigene cluster: Hs.116147
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells
SABiosciences Custom PCR Arrays for ADAM7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM7 |
Orthologs
for ADAM7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for ADAM7 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADAM286 |
Uncharacterized protein |
33(a) |
1 → many |
22(1055455-1073618) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
38(a) |
1 → many |
GL343422.1(144507-180281) |
zebrafish
(Danio rerio) |
Actinopterygii |
adam286 |
a disintegrin and metallopeptidase domain 28 |
32(a) |
1 → many |
5(29542775-29565255) |
ENSEMBL Gene Tree for ADAM7 (if available)
TreeFam Gene Tree for ADAM7 (if available) |
Paralogs
for ADAM7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAM7 gene
- ADAM192 ADAM122 ADAM232 ADAM332 ADAM112 ADAM302 ADAM222 ADAM282
- ADAM292 ADAM202 ADAM92 ADAM212 ADAM152 ADAM82
16 SIMAP similar genes for ADAM7 using alignment to 5 protein entries: ADAM7_HUMAN (see all proteins):ADAM28 ADAMDEC1 ADAM12 ADAM8 ADAM23 ADAM9
ADAM19 ADAM20 ADAM21 ADAM22 ADAM29 ADAM30
ADAM18 ADAM33 ADAM11 ADAM15
ADAM7 for paralogs About GeneDecksing
|
Genomic Variants
for ADAM7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAM7 (24298443 - 24384483 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADAM7
1 Indel: 28897
Human Gene Mutation Database (HGMD): ADAM7
| 3 SABiosciences Cancer Mutation PCR Assays for ADAM7: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM7 |
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Disorders
/ Diseases
for ADAM7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAM7 for disorders About GeneDecksing
OMIM gene information: 607310
OMIM disorders: --
UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9
Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanomaprogression and metastasis
3  diseases for ADAM7: About MalaCardsepididymitis melanoma neuronitis
Export disorders for ADAM7 gene to outside databases
|
Publications
for ADAM7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PubMed id 21618342)1, 2 Wei X.... Samuels Y. (2011)
- Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PubMed id 11514362)1, 9 Lin Y.C....Liu H.W. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (PubMed id 12514095)1 Seals D.F. and Courtneidge S.A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The ADAMDEC1 (decysin) gene structure: evolution by d uplication in a metalloprotease gene cluster on chromosome 8p12. (PubMed id 12037602)1 Bates E.E....Mueller C.G. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Identification of maturation-related wheat-germ lectin-binding proteins in the culture of human corpus epididymal epithelial cells. (PubMed id 10959503)9 Sun G.H....Chang S.Y. (2000)
|
External Searches for ADAM7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAM7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAM7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAM7 gene:
Search GeneIP for patents involving ADAM7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAM7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAM7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM7 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM7 |
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