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ADAM7 Gene

protein-coding   GIFtS: 52
GCID: GC08P024354

ADAM Metallopeptidase Domain 7

(Previous name: a disintegrin and metalloproteinase domain 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 71 2     ADAM-72
A Disintegrin And Metalloproteinase Domain 71 2     EAPI2
Sperm Maturation-Related Glycoprotein GP-832 3     GP-832
GP832 3     Disintegrin And Metalloproteinase Domain-Containing Protein 72
ADAM 72 3     Epididymal Apical Protein I2

External Ids:    HGNC: 2141   Entrez Gene: 87562   Ensembl: ENSG000000692067   OMIM: 6073105   UniProtKB: Q9H2U93   

Export aliases for ADAM7 gene to outside databases

Previous GC identifers: GC08P024031 GC08P024652 GC08P024321 GC08P024322 GC08P022843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM7 Gene:
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in
multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity
and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion.
Mutations in this gene may be involved in the progression of melanoma. (provided by RefSeq, Oct 2011)

GeneCards Summary for ADAM7 Gene:
ADAM7 (ADAM metallopeptidase domain 7) is a protein-coding gene. Diseases associated with ADAM7 include epididymitis, and melanoma. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM19.

UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9
Function: May play an important role in male reproduction including sperm maturation and gonadotrope function.
This is a non catalytic metalloprotease-like protein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM7 gene promoter:
         C/EBPbeta   Pax-2   Pax-2a   CUTL1   YY1   MEF-2A   IRF-2   Pax-2b   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM7 promoter sequence
   Search Chromatin IP Primers for ADAM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

ADAM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P024354:  view genomic region     (about GC identifiers)

Start:
24,298,443 bp from pter      End:
24,384,483 bp from pter
Size:
86,041 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 7 precursor  
Size: 754 amino acids; 85669 Da
Secondary accessions: A8K8X7 O75959

Explore the universe of human proteins at neXtProt for ADAM7: NX_Q9H2U9

Explore proteomics data for ADAM7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn167, Asn174, Asn184, Asn584, Asn668
  • Modification sites at PhosphoSitePlus

  • See ADAM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003808.2  
    ENSEMBL proteins: 
     ENSP00000393073   ENSP00000175238   ENSP00000370166   ENSP00000430400  

    ADAM7 Human Recombinant Protein Products:

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    Novus Biologicals ADAM7 Lysate
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    Cloud-Clone Corp. Proteins for ADAM7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM7
    ADAM

    Selected InterPro protein domains (see all 6):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9H2U9

    ProtoNet protein and cluster: Q9H2U9

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM7_HUMAN, Q9H2U9
    Function: May play an important role in male reproduction including sperm maturation and gonadotrope function.
    This is a non catalytic metalloprotease-like protein (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ADAM7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAM7:
     Decreased POU5F1-GFP protein e  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADAM7_HUMAN, Q9H2U9: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    ADAM7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM7 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch Signaling Pathway (sino)
    Notch Signaling Pathway


    1 Sino Biological Pathway for ADAM7
        Notch Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM7
    Interactions:

        Search GeneGlobe Interaction Network for ADAM7

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    ADAM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM7 gene: 
    NM_003817.3  

    Unigene Cluster for ADAM7:

    ADAM metallopeptidase domain 7
    Hs.116147  [show with all ESTs]
    Unigene Representative Sequence: NM_003817
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441335(uc003xea.1) ENST00000175238(uc003xeb.3) ENST00000380789
    ENST00000520720(uc003xec.3)
    miRNA
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ADAM7
      QuantiFast Probe-based Assays in human, mouse, rat ADAM7

    Additional mRNA sequence: 

    AF090327.1 AF215824.1 AK292492.1 BC043207.2 BC058037.1 

    4 DOTS entries:

    DT.92414785  DT.208020  DT.99959504  DT.91988055 

    12 AceView cDNA sequences:

    BC043207 NM_003817 BG718002 BC058037 AL705011 BU569298 BX109205 BI559778 
    AF090327 AF215824 AI699458 BU570785 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGGTCT
    ADAM7 Expression
    About this image

    ADAM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116147

    UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9
    Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells

        Custom PCR Arrays for ADAM7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam71 , 5 a disintegrin and metallopeptidase domain 71, 5 76.79(n)1
    68.58(a)1
      14 (35.69 cM)5
    115001  NM_007402.21  NP_031428.21 
     684973365 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    35(a)
    1 → many
    22(1041606-1057979)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    1 → many
    GL343422.1(136760-191906)
    zebrafish
    (Danio rerio)
    Actinopterygii adam286
    a disintegrin and metallopeptidase domain 28
    33(a)
    1 → many
    5(29542775-29565255) ENSDARG00000035514


    ENSEMBL Gene Tree for ADAM7 (if available)
    TreeFam Gene Tree for ADAM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM7 gene
    ADAM192  ADAM122  ADAM332  ADAM302  ADAM282  ADAM292  ADAM202  ADAM212  
    ADAM92  ADAM152  ADAM82  
    16 SIMAP similar genes for ADAM7 using alignment to 5 protein entries:     ADAM7_HUMAN (see all proteins):
    ADAM28    ADAMDEC1    ADAM12    ADAM8    ADAM23    ADAM9
    ADAM19    ADAM20    ADAM21    ADAM22    ADAM29    ADAM30
    ADAM15    ADAM33    ADAM11    ADAM18

    ADAM7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM7 (see all 1634)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663074
    A cutaneous metastatic melanoma sample4--see VAR_0663072 E K mis40--------
    VAR_0662964
    A cutaneous metastatic melanoma sample4--see VAR_0662962 P S mis40--------
    VAR_0663014
    A cutaneous metastatic melanoma sample4--see VAR_0663012 V A mis40--------
    VAR_0662984
    A cutaneous metastatic melanoma sample4--see VAR_0662982 P S mis40--------
    VAR_0663084
    A cutaneous metastatic melanoma sample4--see VAR_0663082 S N mis40--------
    VAR_0663054
    A cutaneous metastatic melanoma sample4--see VAR_0663052 G E mis40--------
    VAR_0662994
    A cutaneous metastatic melanoma sample4--see VAR_0662992 H Y mis40--------
    VAR_0663034
    A cutaneous metastatic melanoma sample4--see VAR_0663032 G E mis40--------
    VAR_0663044
    A cutaneous metastatic melanoma sample4--see VAR_0663042 M I mis40--------
    VAR_0662974
    A cutaneous metastatic melanoma sample4--see VAR_0662972 R C mis40--------

    HapMap Linkage Disequilibrium report for ADAM7 (24298443 - 24384483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ADAM7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672980CNV Deletion23128226
    esv2736766CNV Deletion23290073
    esv1752768CNV Deletion17803354
    esv1005603CNV Deletion20482838
    esv1347031CNV Insertion17803354
    nsv397333CNV Insertion16902084
    dgv452n21CNV Loss19592680
    nsv890683CNV Gain21882294
    nsv890682CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADAM7
    3 Site Specific Mutation Identification with PCR Assays for ADAM7:
    Cosmic IdAA Change
    106832p.R31C
    142119p.G302E
    109103p.P14S
    SeqTarget long-range PCR primers for resequencing ADAM7
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607310    OMIM disorders: --

    UniProtKB/Swiss-Prot: ADAM7_HUMAN, Q9H2U9
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma
    progression and metastasis

  • 6 diseases for ADAM7:    
    About MalaCards
    epididymitis    melanoma    bipolar disorder    multiple myeloma
    myeloma    endotheliitis


    ADAM7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAM7

    Export disorders for ADAM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM7 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ADAM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PubMed id 21618342)1, 2 Wei X.... Samuels Y. (Hum. Mutat. 2011)
    2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PubMed id 11514362)1, 9 Lin Y.C....Liu H.W. (Biol. Reprod. 2001)
    3. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PubMed id 23218918)1 Sprooten E....McIntosh A.M. (Psychiatry Res 2013)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    6. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (PubMed id 12514095)1 Seals D.F. and Courtneidge S.A. (amp 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8756 HGNC: 214 AceView: ADAM7 Ensembl:ENSG00000069206 euGenes: HUgn8756
    ECgene: ADAM7 H-InvDB: ADAM7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM7 gene:
    Search GeneIP for patents involving ADAM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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