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Aliases for ADAM7 Gene

Aliases for ADAM7 Gene

  • ADAM Metallopeptidase Domain 7 2 3
  • A Disintegrin And Metalloproteinase Domain 7 2 3
  • Sperm Maturation-Related Glycoprotein GP-83 3 4
  • ADAM 7 3 4
  • GP83 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 7 3
  • Epididymal Apical Protein I 3
  • ADAM-7 3
  • GP-83 3
  • EAPI 3

External Ids for ADAM7 Gene

Previous GeneCards Identifiers for ADAM7 Gene

  • GC08P024031
  • GC08P024652
  • GC08P024321
  • GC08P024322
  • GC08P022843

Summaries for ADAM7 Gene

Entrez Gene Summary for ADAM7 Gene

  • This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

GeneCards Summary for ADAM7 Gene

ADAM7 (ADAM Metallopeptidase Domain 7) is a Protein Coding gene. Diseases associated with ADAM7 include melanoma. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM7 Gene

  • May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM7 Gene

Genomics for ADAM7 Gene

Regulatory Elements for ADAM7 Gene

Genomic Location for ADAM7 Gene

Start:
24,440,930 bp from pter
End:
24,526,970 bp from pter
Size:
86,041 bases
Orientation:
Plus strand

Genomic View for ADAM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM7 Gene

Proteins for ADAM7 Gene

  • Protein details for ADAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2U9-ADAM7_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
    Protein Accession:
    Q9H2U9
    Secondary Accessions:
    • A8K8X7
    • O75959
    • Q6PEJ6

    Protein attributes for ADAM7 Gene

    Size:
    754 amino acids
    Molecular mass:
    85669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM7 Gene

Proteomics data for ADAM7 Gene at MOPED

Post-translational modifications for ADAM7 Gene

  • Glycosylation at Asn84, Asn167, Asn174, Asn184, Asn584, and Asn668
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM7 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ADAM7

No data available for DME Specific Peptides for ADAM7 Gene

Domains for ADAM7 Gene

Gene Families for ADAM7 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2U9

UniProtKB/Swiss-Prot:

ADAM7_HUMAN :
  • Q9H2U9
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM7: view

Function for ADAM7 Gene

Molecular function for ADAM7 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

Gene Ontology (GO) - Molecular Function for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM7: view

Phenotypes for ADAM7 Gene

GenomeRNAi human phenotypes for ADAM7:
genes like me logo Genes that share phenotypes with ADAM7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM7 Gene

Localization for ADAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM7 Gene COMPARTMENTS Subcellular localization image for ADAM7 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM7: view

Pathways for ADAM7 Gene

SuperPathways for ADAM7 Gene

Superpath Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAM7: view

Pathways by source for ADAM7 Gene

1 Sino Biological pathway for ADAM7 Gene

Interacting Proteins for ADAM7 Gene

Gene Ontology (GO) - Biological Process for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM7: view

Transcripts for ADAM7 Gene

mRNA/cDNA for ADAM7 Gene

Unigene Clusters for ADAM7 Gene

ADAM metallopeptidase domain 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM7 Gene

No ASD Table

Relevant External Links for ADAM7 Gene

GeneLoc Exon Structure for
ADAM7
ECgene alternative splicing isoforms for
ADAM7

Expression for ADAM7 Gene

mRNA expression in normal human tissues for ADAM7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM7 Gene

This gene is overexpressed in Testis (41.1) and Pancreas (6.5).

Protein differential expression in normal tissues for ADAM7 Gene

This gene is overexpressed in Fetal ovary (44.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAM7 Gene

SOURCE GeneReport for Unigene cluster for ADAM7 Gene Hs.116147

mRNA Expression by UniProt/SwissProt for ADAM7 Gene

Q9H2U9-ADAM7_HUMAN
Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells.
genes like me logo Genes that share expressions with ADAM7: view

Expression partners for ADAM7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM7 Gene

Orthologs for ADAM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM7 35
  • 81.68 (n)
  • 72.18 (a)
ADAM7 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM7 35
  • 82.85 (n)
  • 72.15 (a)
ADAM7 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam7 35
  • 76.79 (n)
  • 68.58 (a)
Adam7 16
Adam7 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM7 35
  • 99.03 (n)
  • 98.28 (a)
ADAM7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam7 35
  • 76.65 (n)
  • 68.18 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM7 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM7 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii adam28 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for ADAM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM7 Gene

ENSEMBL:
Gene Tree for ADAM7 (if available)
TreeFam:
Gene Tree for ADAM7 (if available)

Paralogs for ADAM7 Gene

genes like me logo Genes that share paralogs with ADAM7: view

Variants for ADAM7 Gene

Sequence variations from dbSNP and Humsavar for ADAM7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_046728 -
VAR_046729 -
VAR_046730 -
VAR_046731 -
VAR_046732 -

Structural Variations from Database of Genomic Variants (DGV) for ADAM7 Gene

Variant ID Type Subtype PubMed ID
nsv890682 CNV Gain 21882294
nsv890683 CNV Gain 21882294
dgv452n21 CNV Loss 19592680
esv1347031 CNV Insertion 17803354
nsv397333 CNV Insertion 16902084
esv2672980 CNV Deletion 23128226
esv2736766 CNV Deletion 23290073
esv1005603 CNV Deletion 20482838
esv1752768 CNV Deletion 17803354

Relevant External Links for ADAM7 Gene

HapMap Linkage Disequilibrium report
ADAM7
Human Gene Mutation Database (HGMD)
ADAM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM7 Gene

Disorders for ADAM7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADAM7 Gene in MalaCards »

(1) Diseases for ADAM7 Gene including...

UniProtKB/Swiss-Prot

ADAM7_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Relevant External Links for ADAM7

Genetic Association Database (GAD)
ADAM7
genes like me logo Genes that share disorders with ADAM7: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAM7 Gene

Publications for ADAM7 Gene

  1. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X. … Samuels Y. (Hum. Mutat. 2011) 3 4
  2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PMID: 11514362) Lin Y.C. … Liu H.W. (Biol. Reprod. 2001) 3 23
  3. The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. (PMID: 12037602) Bates E.E. … Mueller C.G. (Immunogenetics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (PMID: 12514095) Seals D.F. … Courtneidge S.A. (Genes Dev. 2003) 3

Products for ADAM7 Gene

Sources for ADAM7 Gene

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