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Aliases for ADAM7 Gene

Aliases for ADAM7 Gene

  • ADAM Metallopeptidase Domain 7 2 3 5
  • A Disintegrin And Metalloproteinase Domain 7 2 3
  • Sperm Maturation-Related Glycoprotein GP-83 3 4
  • ADAM 7 3 4
  • GP83 3 4
  • Epididymal Apical Protein I 3
  • ADAM-7 3
  • GP-83 3
  • EAPI 3

External Ids for ADAM7 Gene

Previous GeneCards Identifiers for ADAM7 Gene

  • GC08P024031
  • GC08P024652
  • GC08P024321
  • GC08P024322
  • GC08P022843

Summaries for ADAM7 Gene

Entrez Gene Summary for ADAM7 Gene

  • This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

GeneCards Summary for ADAM7 Gene

ADAM7 (ADAM Metallopeptidase Domain 7) is a Protein Coding gene. Diseases associated with ADAM7 include Melanoma. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM7 Gene

  • May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM7 Gene

Genomics for ADAM7 Gene

Regulatory Elements for ADAM7 Gene

Enhancers for ADAM7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM7 Gene

24,440,930 bp from pter
24,526,970 bp from pter
86,041 bases
Plus strand

Genomic View for ADAM7 Gene

Genes around ADAM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM7 Gene

Proteins for ADAM7 Gene

  • Protein details for ADAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A8K8X7
    • O75959
    • Q6PEJ6

    Protein attributes for ADAM7 Gene

    754 amino acids
    Molecular mass:
    85669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM7 Gene


neXtProt entry for ADAM7 Gene

Proteomics data for ADAM7 Gene at MOPED

Post-translational modifications for ADAM7 Gene

  • Glycosylation at Asn 84, Asn 167, Asn 174, Asn 184, Asn 584, and Asn 668
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM7 Gene

No data available for DME Specific Peptides for ADAM7 Gene

Domains & Families for ADAM7 Gene

Gene Families for ADAM7 Gene

Suggested Antigen Peptide Sequences for ADAM7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 disintegrin domain.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM7: view

Function for ADAM7 Gene

Molecular function for ADAM7 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).
genes like me logo Genes that share phenotypes with ADAM7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM7 Gene

Localization for ADAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ADAM7 Gene COMPARTMENTS Subcellular localization image for ADAM7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADAM7 Gene

Pathways & Interactions for ADAM7 Gene

SuperPathways for ADAM7 Gene

Superpath Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAM7: view

Pathways by source for ADAM7 Gene

1 Sino Biological pathway for ADAM7 Gene

Interacting Proteins for ADAM7 Gene

Gene Ontology (GO) - Biological Process for ADAM7 Gene


No data available for SIGNOR curated interactions for ADAM7 Gene

Drugs & Compounds for ADAM7 Gene

No Compound Related Data Available

Transcripts for ADAM7 Gene

mRNA/cDNA for ADAM7 Gene

Unigene Clusters for ADAM7 Gene

ADAM metallopeptidase domain 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM7 Gene

No ASD Table

Relevant External Links for ADAM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM7 Gene

mRNA expression in normal human tissues for ADAM7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM7 Gene

This gene is overexpressed in Testis (x41.1) and Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for ADAM7 Gene

This gene is overexpressed in Fetal ovary (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM7 Gene

SOURCE GeneReport for Unigene cluster for ADAM7 Gene Hs.116147

mRNA Expression by UniProt/SwissProt for ADAM7 Gene

Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells.
genes like me logo Genes that share expression patterns with ADAM7: view

Protein tissue co-expression partners for ADAM7 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM7 Gene

Orthologs for ADAM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAM7 35
  • 81.68 (n)
  • 72.18 (a)
ADAM7 36
  • 70 (a)
(Canis familiaris)
Mammalia ADAM7 35
  • 82.85 (n)
  • 72.15 (a)
ADAM7 36
  • 69 (a)
(Mus musculus)
Mammalia Adam7 35
  • 76.79 (n)
  • 68.58 (a)
Adam7 16
Adam7 36
  • 65 (a)
(Pan troglodytes)
Mammalia ADAM7 35
  • 99.03 (n)
  • 98.28 (a)
ADAM7 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Adam7 35
  • 76.65 (n)
  • 68.18 (a)
(Monodelphis domestica)
Mammalia ADAM7 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia ADAM7 36
  • 53 (a)
(Gallus gallus)
Aves -- 36
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
(Danio rerio)
Actinopterygii adam28 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for ADAM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM7 Gene

Gene Tree for ADAM7 (if available)
Gene Tree for ADAM7 (if available)

Paralogs for ADAM7 Gene

genes like me logo Genes that share paralogs with ADAM7: view

Variants for ADAM7 Gene

Sequence variations from dbSNP and Humsavar for ADAM7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_046728 -
VAR_046729 -
VAR_046730 -
VAR_046731 -
VAR_046732 -

Structural Variations from Database of Genomic Variants (DGV) for ADAM7 Gene

Variant ID Type Subtype PubMed ID
nsv890682 CNV Gain 21882294
nsv890683 CNV Gain 21882294
dgv452n21 CNV Loss 19592680
esv1347031 CNV Insertion 17803354
nsv397333 CNV Insertion 16902084
esv2672980 CNV Deletion 23128226
esv2736766 CNV Deletion 23290073
esv1005603 CNV Deletion 20482838
esv1752768 CNV Deletion 17803354

Variation tolerance for ADAM7 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.97; 87.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM7 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM7 Gene

Disorders for ADAM7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards
Search ADAM7 in MalaCards View complete list of genes associated with diseases


  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. {ECO:0000269 PubMed:21618342}.

Relevant External Links for ADAM7

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADAM7: view

No data available for Genatlas for ADAM7 Gene

Publications for ADAM7 Gene

  1. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X. … Samuels Y. (Hum. Mutat. 2011) 3 4 67
  2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PMID: 11514362) Lin Y.C. … Liu H.W. (Biol. Reprod. 2001) 3 23
  3. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E. … McIntosh A.M. (Psychiatry Res 2013) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (PMID: 12514095) Seals D.F. … Courtneidge S.A. (Genes Dev. 2003) 3

Products for ADAM7 Gene

Sources for ADAM7 Gene