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Aliases for ADAM7 Gene

Aliases for ADAM7 Gene

  • ADAM Metallopeptidase Domain 7 2 3 5
  • A Disintegrin And Metalloproteinase Domain 7 2 3
  • Sperm Maturation-Related Glycoprotein GP-83 3 4
  • ADAM 7 3 4
  • GP83 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 7 3
  • Epididymal Apical Protein I 3
  • ADAM-7 3
  • GP-83 3
  • EAPI 3

External Ids for ADAM7 Gene

Previous GeneCards Identifiers for ADAM7 Gene

  • GC08P024031
  • GC08P024652
  • GC08P024321
  • GC08P024322
  • GC08P022843

Summaries for ADAM7 Gene

Entrez Gene Summary for ADAM7 Gene

  • This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

GeneCards Summary for ADAM7 Gene

ADAM7 (ADAM Metallopeptidase Domain 7) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAM28.

UniProtKB/Swiss-Prot for ADAM7 Gene

  • May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM7 Gene

Genomics for ADAM7 Gene

Regulatory Elements for ADAM7 Gene

Enhancers for ADAM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F024418 0.8 Ensembl ENCODE 16 -22.1 -22092 1.3 CTCF ZNF654 CEBPB SMC3 RAD21 ADAM7 LOC101929315 PIR51295
GH08F024509 0.9 Ensembl ENCODE 10.9 +68.6 68597 0.6 ZBED1 CBFB JUND CBX5 TARDBP NBN NFE2 FOXP2 MLLT1 ETV6 ADAM7 LOC101929315
GH08F024383 1.2 FANTOM5 ENCODE 5.6 -54.5 -54503 5.4 CTCF PKNOX1 EBF1 RAD21 TEAD3 RELA ZNF547 ZNF143 SMC3 CHD2 ADAMDEC1 ADAM28 ADAM7 PIR51295
GH08F024414 1 Ensembl ENCODE 0.3 -25.7 -25713 0.6 CTCF ZNF654 USF1 WRNIP1 MAX USF2 RAD21 RELA TGIF2 JUND PIR51295 ADAM7
GH08F024511 0.6 Ensembl 0.2 +70.8 70817 0.3 CTCF ZNF654 SMARCA4 RNF2 SMC3 REST RAD21 LOC101929315 ADAM7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM7 Gene

Chromosome:
8
Start:
24,440,930 bp from pter
End:
24,526,970 bp from pter
Size:
86,041 bases
Orientation:
Plus strand

Genomic View for ADAM7 Gene

Genes around ADAM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM7 Gene

Proteins for ADAM7 Gene

  • Protein details for ADAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2U9-ADAM7_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
    Protein Accession:
    Q9H2U9
    Secondary Accessions:
    • A8K8X7
    • O75959
    • Q6PEJ6

    Protein attributes for ADAM7 Gene

    Size:
    754 amino acids
    Molecular mass:
    85669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM7 Gene

Post-translational modifications for ADAM7 Gene

  • Glycosylation at Asn 84, Asn 167, Asn 174, Asn 184, Asn 584, and Asn 668
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM7 Gene

No data available for DME Specific Peptides for ADAM7 Gene

Domains & Families for ADAM7 Gene

Gene Families for ADAM7 Gene

Suggested Antigen Peptide Sequences for ADAM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2U9

UniProtKB/Swiss-Prot:

ADAM7_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM7: view

Function for ADAM7 Gene

Molecular function for ADAM7 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

Gene Ontology (GO) - Molecular Function for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM7: view
genes like me logo Genes that share phenotypes with ADAM7: view

Animal Models for ADAM7 Gene

MGI Knock Outs for ADAM7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADAM7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM7 Gene

Localization for ADAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM7: view

Pathways & Interactions for ADAM7 Gene

SuperPathways for ADAM7 Gene

SuperPathway Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAM7: view

Pathways by source for ADAM7 Gene

1 Sino Biological pathway for ADAM7 Gene

Interacting Proteins for ADAM7 Gene

Gene Ontology (GO) - Biological Process for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM7: view

No data available for SIGNOR curated interactions for ADAM7 Gene

Transcripts for ADAM7 Gene

mRNA/cDNA for ADAM7 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM7 Gene

ADAM metallopeptidase domain 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADAM7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM7 Gene

No ASD Table

Relevant External Links for ADAM7 Gene

GeneLoc Exon Structure for
ADAM7
ECgene alternative splicing isoforms for
ADAM7

Expression for ADAM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM7 Gene

This gene is overexpressed in Testis (x41.1) and Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for ADAM7 Gene

This gene is overexpressed in Fetal ovary (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM7 Gene



Protein tissue co-expression partners for ADAM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM7 Gene:

ADAM7

SOURCE GeneReport for Unigene cluster for ADAM7 Gene:

Hs.116147

mRNA Expression by UniProt/SwissProt for ADAM7 Gene:

Q9H2U9-ADAM7_HUMAN
Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells.
genes like me logo Genes that share expression patterns with ADAM7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM7 Gene

Orthologs for ADAM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM7 34 35
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia ADAM7 34 35
  • 82.85 (n)
cow
(Bos Taurus)
Mammalia ADAM7 34 35
  • 81.68 (n)
mouse
(Mus musculus)
Mammalia Adam7 34 16 35
  • 76.79 (n)
rat
(Rattus norvegicus)
Mammalia Adam7 34
  • 76.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM7 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM7 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii adam28 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for ADAM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM7 Gene

ENSEMBL:
Gene Tree for ADAM7 (if available)
TreeFam:
Gene Tree for ADAM7 (if available)

Paralogs for ADAM7 Gene

genes like me logo Genes that share paralogs with ADAM7: view

Variants for ADAM7 Gene

Sequence variations from dbSNP and Humsavar for ADAM7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137990671 A cutaneous metastatic melanoma sample 24,442,511(+) TGGTT(C/T)GTCCT intron-variant, reference, missense
rs150319320 A cutaneous metastatic melanoma sample 24,441,148(+) TCATT(C/T)CTCAG intron-variant, reference, missense
rs267601866 A cutaneous metastatic melanoma sample 24,442,526(+) AGCTT(C/T)CTCTG intron-variant, reference, missense
rs267601867 A cutaneous metastatic melanoma sample 24,465,702(+) AGGAT(C/G/T)ATTGT intron-variant, reference, missense
rs267601868 A cutaneous metastatic melanoma sample 24,487,303(+) GTGAT(A/G)GACAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAM7 Gene

Variant ID Type Subtype PubMed ID
nsv397333 CNV insertion 16902084
nsv1076071 CNV deletion 25765185
esv3891377 CNV loss 25118596
esv3543243 CNV deletion 23714750
esv3424387 CNV insertion 20981092
esv2736766 CNV deletion 23290073
esv2672980 CNV deletion 23128226
esv1752768 CNV deletion 17803354
esv1347031 CNV insertion 17803354
esv1005603 CNV deletion 20482838
dgv7141n100 CNV loss 25217958
dgv452n21 CNV loss 19592680

Variation tolerance for ADAM7 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.97; 87.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM7 Gene

Human Gene Mutation Database (HGMD)
ADAM7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM7 Gene

Disorders for ADAM7 Gene

UniProtKB/Swiss-Prot

ADAM7_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. {ECO:0000269 PubMed:21618342}.

Relevant External Links for ADAM7

Genetic Association Database (GAD)
ADAM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM7

No disorders were found for ADAM7 Gene.

No data available for MalaCards and Genatlas for ADAM7 Gene

Publications for ADAM7 Gene

  1. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X. … Samuels Y. (Hum. Mutat. 2011) 3 4 64
  2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PMID: 11514362) Lin Y.C. … Liu H.W. (Biol. Reprod. 2001) 3 22 64
  3. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E. … McIntosh A.M. (Psychiatry Res 2013) 3 64
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for ADAM7 Gene

Sources for ADAM7 Gene

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