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Aliases for ADAM5 Gene

Aliases for ADAM5 Gene

  • ADAM Metallopeptidase Domain 5 (Pseudogene) 2 3 5
  • A Disintegrin And Metalloproteinase Domain 5 2 3
  • ADAM Metallopeptidase Domain 5, Pseudogene 2 3
  • TMDC II 3 4
  • ADAM5P 3 4
  • Putative Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 4
  • TMDCII 3
  • TMDC2 4

External Ids for ADAM5 Gene

Previous HGNC Symbols for ADAM5 Gene

  • ADAM5P

Previous GeneCards Identifiers for ADAM5 Gene

  • GC00U990448
  • GC08P038913
  • GC08P039190
  • GC08P039191

Summaries for ADAM5 Gene

GeneCards Summary for ADAM5 Gene

ADAM5 (ADAM Metallopeptidase Domain 5 (Pseudogene)) is a Pseudogene. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for ADAM5 Gene

  • This is a non catalytic metalloprotease-like protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM5 Gene

Genomics for ADAM5 Gene

Genomic Location for ADAM5 Gene

Chromosome:
8
Start:
39,314,591 bp from pter
End:
39,417,378 bp from pter
Size:
102,788 bases
Orientation:
Plus strand

Genomic View for ADAM5 Gene

Genes around ADAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM5 Gene

No data available for Regulatory Elements for ADAM5 Gene

Proteins for ADAM5 Gene

  • Protein details for ADAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVV9-ADAM5_HUMAN
    Recommended name:
    Putative disintegrin and metalloproteinase domain-containing protein 5
    Protein Accession:
    Q6NVV9
    Secondary Accessions:
    • A8MW71
    • Q4G196

    Protein attributes for ADAM5 Gene

    Size:
    412 amino acids
    Molecular mass:
    47181 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM5 Gene

neXtProt entry for ADAM5 Gene

Proteomics data for ADAM5 Gene at MOPED

Post-translational modifications for ADAM5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAM5 Gene

Domains & Families for ADAM5 Gene

Gene Families for ADAM5 Gene

Protein Domains for ADAM5 Gene

Suggested Antigen Peptide Sequences for ADAM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NVV9

UniProtKB/Swiss-Prot:

ADAM5_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with ADAM5: view

Function for ADAM5 Gene

Molecular function for ADAM5 Gene

UniProtKB/Swiss-Prot Function:
This is a non catalytic metalloprotease-like protein.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM5 Gene

Localization for ADAM5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADAM5 Gene

Pathways & Interactions for ADAM5 Gene

SuperPathways for ADAM5 Gene

No Data Available

Interacting Proteins for ADAM5 Gene

Gene Ontology (GO) - Biological Process for ADAM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADAM5 Gene

Drugs & Compounds for ADAM5 Gene

No Compound Related Data Available

Transcripts for ADAM5 Gene

Unigene Clusters for ADAM5 Gene

ADAM metallopeptidase domain 5, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM5 Gene

No ASD Table

Relevant External Links for ADAM5 Gene

GeneLoc Exon Structure for
ADAM5
ECgene alternative splicing isoforms for
ADAM5

Expression for ADAM5 Gene

mRNA expression in normal human tissues for ADAM5 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM5 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for ADAM5 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM5 Gene



SOURCE GeneReport for Unigene cluster for ADAM5 Gene Hs.369765

mRNA Expression by UniProt/SwissProt for ADAM5 Gene

Q6NVV9-ADAM5_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with ADAM5: view

Protein tissue co-expression partners for ADAM5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM5 Gene

Orthologs for ADAM5 Gene

Evolution for ADAM5 Gene

ENSEMBL:
Gene Tree for ADAM5 (if available)
TreeFam:
Gene Tree for ADAM5 (if available)

No data available for Orthologs for ADAM5 Gene

Paralogs for ADAM5 Gene

(1) SIMAP similar genes for ADAM5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM5: view

No data available for Paralogs for ADAM5 Gene

Variants for ADAM5 Gene

Sequence variations from dbSNP and Humsavar for ADAM5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3924145 -- 39,347,001(-) TATTG(C/T)GCACA intron-variant
rs3935233 -- 39,331,315(-) AAAAC(A/G)GTTTC intron-variant
rs4236759 -- 39,316,760(+) CCTGC(A/G)AAAGT intron-variant
rs4236760 -- 39,332,713(+) TCAGT(A/G)TCTGC intron-variant
rs4236761 -- 39,363,566(+) AAAAA(C/T)AGAAA intron-variant

Relevant External Links for ADAM5 Gene

HapMap Linkage Disequilibrium report
ADAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for ADAM5 Gene

Disorders for ADAM5 Gene

Relevant External Links for ADAM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM5

No disorders were found for ADAM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM5 Gene

Publications for ADAM5 Gene

  1. Transcripts encoding the sperm surface protein tMDC II are non- functional in the human. (PMID: 10417343) Frayne J. … Hall L. (Biochem. J. 1999) 2 3 4 23 67
  2. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. (PMID: 8786143) Cho C. … Myles D.G. (Genomics 1996) 2 3 23
  3. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ADAM5 Gene

Sources for ADAM5 Gene

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