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Aliases for ADAM5 Gene

Aliases for ADAM5 Gene

  • ADAM Metallopeptidase Domain 5 (Pseudogene) 2 3
  • A Disintegrin And Metalloproteinase Domain 5 2 3
  • ADAM Metallopeptidase Domain 5, Pseudogene 2 3
  • TMDC II 3 4
  • ADAM5P 3 4
  • Putative Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 4
  • TMDCII 3
  • TMDC2 4

External Ids for ADAM5 Gene

Previous HGNC Symbols for ADAM5 Gene

  • ADAM5P

Previous GeneCards Identifiers for ADAM5 Gene

  • GC00U990448
  • GC08P038913
  • GC08P039190
  • GC08P039191

Summaries for ADAM5 Gene

GeneCards Summary for ADAM5 Gene

ADAM5 (ADAM Metallopeptidase Domain 5 (Pseudogene)) is a Pseudogene. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for ADAM5 Gene

  • This is a non catalytic metalloprotease-like protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM5 Gene

Genomics for ADAM5 Gene

Genomic Location for ADAM5 Gene

Start:
39,314,591 bp from pter
End:
39,417,378 bp from pter
Size:
102,788 bases
Orientation:
Plus strand

Genomic View for ADAM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM5 Gene

No data available for Regulatory Elements for ADAM5 Gene

Proteins for ADAM5 Gene

  • Protein details for ADAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVV9-ADAM5_HUMAN
    Recommended name:
    Putative disintegrin and metalloproteinase domain-containing protein 5
    Protein Accession:
    Q6NVV9
    Secondary Accessions:
    • A8MW71
    • Q4G196

    Protein attributes for ADAM5 Gene

    Size:
    412 amino acids
    Molecular mass:
    47181 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM5 Gene

neXtProt entry for ADAM5 Gene

Proteomics data for ADAM5 Gene at MOPED

Post-translational modifications for ADAM5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAM5 Gene

Domains for ADAM5 Gene

Gene Families for ADAM5 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Protein Domains for ADAM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NVV9

UniProtKB/Swiss-Prot:

ADAM5_HUMAN :
  • Q6NVV9
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with ADAM5: view

No data available for Suggested Antigen Peptide Sequences for ADAM5 Gene

Function for ADAM5 Gene

Molecular function for ADAM5 Gene

UniProtKB/Swiss-Prot Function: This is a non catalytic metalloprotease-like protein.

Gene Ontology (GO) - Molecular Function for ADAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM5 Gene

Localization for ADAM5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADAM5 Gene

Pathways for ADAM5 Gene

SuperPathways for ADAM5 Gene

No Data Available

Interacting Proteins for ADAM5 Gene

Gene Ontology (GO) - Biological Process for ADAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM5: view

No data available for Pathways by source for ADAM5 Gene

Transcripts for ADAM5 Gene

Unigene Clusters for ADAM5 Gene

ADAM metallopeptidase domain 5, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM5 Gene

No ASD Table

Relevant External Links for ADAM5 Gene

GeneLoc Exon Structure for
ADAM5
ECgene alternative splicing isoforms for
ADAM5

Expression for ADAM5 Gene

mRNA expression in normal human tissues for ADAM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM5 Gene

This gene is overexpressed in Testis (52.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAM5 Gene

SOURCE GeneReport for Unigene cluster for ADAM5 Gene Hs.369765

mRNA Expression by UniProt/SwissProt for ADAM5 Gene

Q6NVV9-ADAM5_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with ADAM5: view

In Situ Assay Products

Orthologs for ADAM5 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ADAM5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Adam5 16
Species with no ortholog for ADAM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM5 Gene

ENSEMBL:
Gene Tree for ADAM5 (if available)
TreeFam:
Gene Tree for ADAM5 (if available)

Paralogs for ADAM5 Gene

Selected SIMAP similar genes for ADAM5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM5: view

No data available for Paralogs for ADAM5 Gene

Variants for ADAM5 Gene

Sequence variations from dbSNP and Humsavar for ADAM5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3205882 -- 39,322,980(+) TTGCA(A/T)TTATA nc-transcript-variant
rs3924145 -- 39,347,001(-) TATTG(C/T)GCACA intron-variant
rs3935233 -- 39,331,315(-) AAAAC(A/G)GTTTC intron-variant
rs4073880 -- 39,315,474(-) GTCTG(C/T)AGGAA nc-transcript-variant
rs4073881 -- 39,315,577(-) AAACG(C/T)AACTT intron-variant

Relevant External Links for ADAM5 Gene

HapMap Linkage Disequilibrium report
ADAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAM5 Gene

Disorders for ADAM5 Gene

No disorders were found for ADAM5 Gene.

No data available for UniProtKB/Swiss-Prot for ADAM5 Gene

Publications for ADAM5 Gene

  1. Transcripts encoding the sperm surface protein tMDC II are non- functional in the human. (PMID: 10417343) Frayne J. … Hall L. (Biochem. J. 1999) 2 3 4 23
  2. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. (PMID: 8786143) Cho C. … Myles D.G. (Genomics 1996) 2 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3
  5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PMID: 22797925) Aichem A. … Groettrup M. (J. Cell. Sci. 2012) 3

Products for ADAM5 Gene

Sources for ADAM5 Gene

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