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Aliases for ADAM5 Gene

Aliases for ADAM5 Gene

  • ADAM Metallopeptidase Domain 5 (Pseudogene) 2 3 5
  • A Disintegrin And Metalloproteinase Domain 5 2 3
  • TMDC II 3 4
  • ADAM5P 3 4
  • Putative Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 4
  • ADAM Metallopeptidase Domain 5, Pseudogene 2
  • TMDCII 3
  • TMDC2 4

External Ids for ADAM5 Gene

Previous HGNC Symbols for ADAM5 Gene

  • ADAM5P

Previous GeneCards Identifiers for ADAM5 Gene

  • GC00U990448
  • GC08P038913
  • GC08P039190
  • GC08P039191

Summaries for ADAM5 Gene

GeneCards Summary for ADAM5 Gene

ADAM5 (ADAM Metallopeptidase Domain 5 (Pseudogene)) is a Pseudogene. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for ADAM5 Gene

  • This is a non catalytic metalloprotease-like protein.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM5 Gene

Genomics for ADAM5 Gene

Regulatory Elements for ADAM5 Gene

Enhancers for ADAM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G039581 0.6 ENCODE 61 +267.4 267367 1.8 PKNOX1 TAL1 TCF12 ARID1B NCOR1 SMARCA4 PBX2 KDM1A FOXP2 ADAM5 LOC100130964 ADAM3A ADAM18 GC08P039555
GH08G039580 0.2 ENCODE 29.1 +265.9 265927 0.8 ADAM5 LOC100130964 ADAM18 GC08P039555
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM5 Gene

Chromosome:
8
Start:
39,314,591 bp from pter
End:
39,417,378 bp from pter
Size:
102,788 bases
Orientation:
Plus strand

Genomic View for ADAM5 Gene

Genes around ADAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM5 Gene

Proteins for ADAM5 Gene

  • Protein details for ADAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVV9-ADAM5_HUMAN
    Recommended name:
    Putative disintegrin and metalloproteinase domain-containing protein 5
    Protein Accession:
    Q6NVV9
    Secondary Accessions:
    • A8MW71
    • Q4G196

    Protein attributes for ADAM5 Gene

    Size:
    412 amino acids
    Molecular mass:
    47181 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM5 Gene

neXtProt entry for ADAM5 Gene

Post-translational modifications for ADAM5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAM5 Gene

Domains & Families for ADAM5 Gene

Gene Families for ADAM5 Gene

Protein Domains for ADAM5 Gene

Suggested Antigen Peptide Sequences for ADAM5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM5: view

No data available for UniProtKB/Swiss-Prot for ADAM5 Gene

Function for ADAM5 Gene

Molecular function for ADAM5 Gene

UniProtKB/Swiss-Prot Function:
This is a non catalytic metalloprotease-like protein.

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM5 Gene

Localization for ADAM5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADAM5 Gene

Pathways & Interactions for ADAM5 Gene

SuperPathways for ADAM5 Gene

No Data Available

Interacting Proteins for ADAM5 Gene

Gene Ontology (GO) - Biological Process for ADAM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADAM5 Gene

Drugs & Compounds for ADAM5 Gene

No Compound Related Data Available

Transcripts for ADAM5 Gene

Unigene Clusters for ADAM5 Gene

ADAM metallopeptidase domain 5, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM5 Gene

No ASD Table

Relevant External Links for ADAM5 Gene

GeneLoc Exon Structure for
ADAM5
ECgene alternative splicing isoforms for
ADAM5

Expression for ADAM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM5 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM5 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for ADAM5 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM5 Gene



Protein tissue co-expression partners for ADAM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM5 Gene:

ADAM5

SOURCE GeneReport for Unigene cluster for ADAM5 Gene:

Hs.369765

mRNA Expression by UniProt/SwissProt for ADAM5 Gene:

Q6NVV9-ADAM5_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with ADAM5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM5 Gene

Orthologs for ADAM5 Gene

Evolution for ADAM5 Gene

ENSEMBL:
Gene Tree for ADAM5 (if available)
TreeFam:
Gene Tree for ADAM5 (if available)

No data available for Orthologs for ADAM5 Gene

Paralogs for ADAM5 Gene

(1) SIMAP similar genes for ADAM5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM5: view

No data available for Paralogs for ADAM5 Gene

Variants for ADAM5 Gene

Sequence variations from dbSNP and Humsavar for ADAM5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000053307 -- 39,375,184(+) AACAT(A/G)AAATT intron-variant
rs1000071172 -- 39,354,956(+) TTAGT(A/G)TTTTA intron-variant
rs1000144539 -- 39,334,829(+) TTCCC(A/G)TATAA intron-variant
rs1000192776 -- 39,415,932(+) ATTAC(A/T)AATAC intron-variant
rs1000194882 -- 39,360,366(+) AGATG(A/G)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM5 Gene

Variant ID Type Subtype PubMed ID
dgv1179n67 CNV loss 20364138
dgv12091n54 CNV gain 21841781
dgv12092n54 CNV loss 21841781
dgv12093n54 CNV gain 21841781
dgv12094n54 CNV gain+loss 21841781
dgv12095n54 CNV loss 21841781
dgv12096n54 CNV loss 21841781
dgv12097n54 CNV loss 21841781
dgv12098n54 CNV gain+loss 21841781
dgv12099n54 CNV gain 21841781
dgv12100n54 CNV gain+loss 21841781
dgv12101n54 CNV loss 21841781
dgv12102n54 CNV gain+loss 21841781
dgv12103n54 CNV loss 21841781
dgv1282e199 CNV deletion 23128226
dgv146n17 CNV loss 16327808
dgv181e180 CNV loss 20482838
dgv2066e212 CNV gain 25503493
dgv2067e212 CNV gain 25503493
dgv2068e212 CNV loss 25503493
dgv266n111 CNV deletion 26073780
dgv35e209 CNV deletion 24192839
dgv3807n106 CNV deletion 24896259
dgv67e213 CNV loss 24956385
dgv7166n100 CNV gain 25217958
dgv7167n100 CNV gain 25217958
dgv7168n100 CNV loss 25217958
dgv7169n100 CNV gain 25217958
dgv7170n100 CNV gain+loss 25217958
dgv7171n100 CNV loss 25217958
dgv7172n100 CNV gain 25217958
dgv7173n100 CNV gain+loss 25217958
dgv7174n100 CNV loss 25217958
dgv7175n100 CNV gain 25217958
dgv7176n100 CNV loss 25217958
esv1005931 CNV loss 20482838
esv21867 CNV gain+loss 19812545
esv2421469 CNV deletion 20811451
esv2736900 CNV deletion 23290073
esv2759608 CNV gain+loss 17122850
esv2761164 CNV loss 21179565
esv2764074 CNV gain+loss 21179565
esv32816 CNV loss 17666407
esv33764 CNV loss 17666407
esv3447334 CNV insertion 20981092
esv3543387 CNV deletion 23714750
esv3572689 CNV loss 25503493
esv3616947 CNV loss 21293372
esv3616948 CNV loss 21293372
esv3891382 CNV loss 25118596
esv3891383 CNV loss 25118596
esv3891385 CNV loss 25118596
esv994752 CNV gain 20482838
esv995573 CNV deletion 20482838
nsv1015371 CNV loss 25217958
nsv1024969 CNV gain 25217958
nsv1074232 CNV deletion 25765185
nsv428198 CNV gain 18775914
nsv433493 CNV loss 18776910
nsv438050 CNV loss 16468122
nsv442511 CNV loss 18776908
nsv508503 CNV deletion 20534489
nsv511391 CNV gain 21212237
nsv515081 CNV loss 21397061
nsv527334 CNV loss 19592680
nsv528858 CNV loss 19592680
nsv610957 CNV gain 21841781
nsv610958 CNV gain 21841781
nsv610974 CNV loss 21841781
nsv610976 CNV gain 21841781
nsv611021 CNV loss 21841781
nsv6163 CNV deletion 18451855
nsv819496 CNV gain 19587683
nsv820723 CNV deletion 20802225
nsv8331 CNV gain+loss 18304495
nsv951129 CNV deletion 24416366
nsv972230 CNV deletion 23825009

Relevant External Links for ADAM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ADAM5 Gene

Disorders for ADAM5 Gene

Relevant External Links for ADAM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM5

No disorders were found for ADAM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM5 Gene

Publications for ADAM5 Gene

  1. Transcripts encoding the sperm surface protein tMDC II are non- functional in the human. (PMID: 10417343) Frayne J. … Hall L. (Biochem. J. 1999) 2 3 4 22 64
  2. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. (PMID: 8786143) Cho C. … Myles D.G. (Genomics 1996) 2 3 22 64
  3. A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts. (PMID: 25776870) Younkin S.G. … Ruczinski I. (Birth Defects Res. Part A Clin. Mol. Teratol. 2015) 3 64
  4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3 64
  5. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H. … DePinho R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 64

Products for ADAM5 Gene

Sources for ADAM5 Gene

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