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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAM5 Gene

pseudogene GIFtS: 35
GCID: GC08P039191

ADAM metallopeptidase domain 5, pseudogene

(Previous name: a disintegrin and metalloproteinase domain 5 )
(Previous symbol: ADAM5P)

Search for ADAM5
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADAM Metallopeptidase Domain 5, Pseudogene¹ ²		TMDCII²
ADAM5P¹ ² ³		TMDC2³
A Disintegrin And Metalloproteinase Domain 5¹		Putative Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II³
TMDCII²		TMDC II³

External Ids:	HGNC: 212¹	Entrez Gene: 255926²	Ensembl: ENSG00000196115⁷	UniProtKB: Q6NVV9³

ORGUL members:
	NONCODE:n385385 n385384 n385382 n385386 n385387	see all 7

Export aliases for ADAM5 gene to outside databases

Previous GC identifers: GC00U990448 GC08P038913 GC08P039190 GC08P039291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ADAM5_HUMAN, Q6NVV9

Function: This is a non catalytic metalloprotease-like protein (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ADAM5
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p11.23

ADAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM5 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039191: view genomic region (about GC identifiers)

Start:	39,172,110 bp from pter	End:	39,274,897 bp from pter
Size:	102,788 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ADAM5

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADAM5_HUMAN, Q6NVV9 (See protein sequence)

Recommended Name: Putative disintegrin and metalloproteinase domain-containing protein 5

Size: 412 amino acids; 47181 Da

Caution: Could be the product of a pseudogene. Not expected to have protease activity

Secondary accessions: A8MW71 Q4G196

Alternative splicing: 7 isoforms: Q6NVV9-1 Q6NVV9-2 Q6NVV9-3 Q6NVV9-4 Q6NVV9-5 Q6NVV9-6 Q6NVV9-7

Explore the universe of human proteins at neXtProt for ADAM5: NX_Q6NVV9

ADAM5 Protein expression data from MOPED and PaxDb: --

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAM5 for domains About GeneDecksing

5 InterPro domains/families:

IPR001762 Blood-coag_inhib_Disintegrin

IPR006586 ADAM_Cys-rich

IPR000742 EG-like_dom

IPR013032 EGF-like_CS

IPR002870 Peptidase_M12B_N

Graphical View of Domain Structure for InterPro Entry Q6NVV9

ProtoNet protein and cluster: Q6NVV9

1 Blocks protein family: IPB001762 Disintegrin

UniProtKB/Swiss-Prot: ADAM5_HUMAN, Q6NVV9

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADAM5_HUMAN, Q6NVV9

Function: This is a non catalytic metalloprotease-like protein (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

ADAM5 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAM5

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

ADAM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about ADAM5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ADAM5 gene:

NM_001040073.1

Unigene Cluster for ADAM5:

ADAM metallopeptidase domain 5, pseudogene

Hs.369765 [show with all ESTs]

Unigene Representative Sequence: BC047448

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000399789(uc003xmx.1 uc003xna.3) ENST00000505455(uc003xnb.3)

ENST00000497773(uc003xmw.3) ENST00000359790(uc003xnc.3) ENST00000464901

ENST00000417441(uc010lws.1 uc010lwt.1 uc010lwu.1) ENST00000433441(uc003xmz.1)

ENST00000512764(uc003xmy.1) ENST00000519063 ENST00000518020 ENST00000498728

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Additional cDNA sequence:

AJ132820.1 AJ132821.1 AJ132822.1 AJ132823.1 AJ132824.1 AJ132825.1 AJ132826.1 AJ132827.1

BC047448.1 BC057230.1 NR_001448.1

9 DOTS entries:

DT.101973909 DT.40302868 DT.95342642 DT.91819019 DT.100711020 DT.405879 DT.97793422 DT.86847564

DT.95260569

24/34 AceView cDNA sequences (see all 34):

AJ132825 BX089826 AI806014 AJ132824 AA629389 BI829318 BG718414 BI559754

AA918208 BX092331 AI400612 BQ429588 BU561620 BI560028 BC057230 AI024863

BV200600 BU569030 AW589885 BQ441614 AA868698 AW779125 BI562095 BC047448

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ADAM5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for ADAM5

SOURCE GeneReport for Unigene cluster: Hs.369765

UniProtKB/Swiss-Prot: ADAM5_HUMAN, Q6NVV9

Tissue specificity: Highly expressed in testis

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ADAM5 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adam5⁵	a disintegrin and metallopeptidase domain 5	--		8 (13.26 cM) 24727093

ENSEMBL Gene Tree for ADAM5 (if available)
TreeFam Gene Tree for ADAM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117913270^1,2	F	--	39170315(+)	`TCCTGA/TTGATA`	1	--	us2k¹		1		NA	120
rs75139502^1,2	C,F	--	39170344(+)	`TATACT/CCCTAT`	1	--	us2k¹		1		EA	120
rs151049152^1,2		--	39170489(+)	`CTTCTA/CGATTA`	1	--	us2k¹		0	--	--	--	--
rs140912103^1,2		--	39170508(+)	`ATATGC/TTTTCA`	1	--	us2k¹		0	--	--	--	--
rs184442247^1,2		--	39170629(+)	`TTTCTC/TCTACG`	1	--	us2k¹		0	--	--	--	--
rs189559786^1,2		--	39170666(+)	`CGTCAA/GATTTT`	1	--	us2k¹		0	--	--	--	--
rs28507401^1,2	C,F	--	39170678(+)	`TTTGAA/TTTTAT`	1	--	us2k¹		1		WA	118
rs61624621^1,2	C	--	39170895(+)	`TGTGT-/GTG TGTGTTTTCC`	1	--	us2k¹		0	--	--	--	--
rs71218323^1,2	C	--	39170934(-)	`GGAAAACACAC/- ACACA`	1	--	us2k¹		1		NA	2
rs10087894^1,2	C,F,H	--	39170959(+)	`TTTGCA/GATCTC`	1	--	us2k¹		18		NS EA NA CSA WA	2334

HapMap Linkage Disequilibrium report for ADAM5 (39172110 - 39274897 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM5: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAM5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM5)

Utopia: connect your pdf to the dynamic
world of online information

Transcripts encoding the sperm surface protein tMDC II are non- functional in the human. (PubMed id 10417343)^{1, 2, 3, 9} Frayne J.... Hall L. (1999)
Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. (PubMed id 8786143)^{1, 3, 9} Cho C....Myles D.G. (1996)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)¹ Zhang Z.D....Gerstein M. (2010)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255926	HGNC: 212	AceView: ADAM5	Ensembl:ENSG00000196115	euGenes: HUgn255926
ECgene: ADAM5	H-InvDB: ADAM5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADAM5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAM5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADAM5 gene:
Search GeneIP for patents involving ADAM5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADAM5 gene at Home site.

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ADAM5 Gene

ADAM metallopeptidase domain 5, pseudogene

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ADAM5 Gene

ADAM metallopeptidase domain 5, pseudogene

Aliasesfor ADAM5 gene

Summariesfor ADAM5 gene

Genomic Viewsfor ADAM5 gene

Proteinsfor ADAM5 gene

Protein Domains /Familiesfor ADAM5 gene

Functionfor ADAM5 gene

Pathways & Interactionsfor ADAM5 gene

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Genome Databases showing ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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Families
for ADAM5 gene

Function
for ADAM5 gene

Pathways & Interactions
for ADAM5 gene

Drugs & Compounds
for ADAM5 gene

Transcripts
for ADAM5 gene

Expression
for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene

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for ADAM5 gene