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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM3A Gene

pseudogene   GIFtS: 32
GCID: GC08M039325

ADAM Metallopeptidase Domain 3A (Pseudogene)

(Previous names: cyritestin 1, a disintegrin and metalloproteinase domain...)
(Previous symbol: CYRN1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADAM Metallopeptidase Domain 3A (Pseudogene)1 2     ADAM Metallopeptidase Domain 3A, Pseudogene1
CYRN11 2     Cyritestin 11
A Disintegrin And Metalloproteinase Domain 3a (Cyritestin 1)1     ADAM32
ADAM Metallopeptidase Domain 3A1     tMDCI2

External Ids:    HGNC: 2091   Entrez Gene: 15872   Ensembl: ENSG000001974757   
ORGUL members:         
NONCODE14:n406589 n405371      

Export aliases for ADAM3A gene to outside databases

Previous GC identifers: GC08U990016 GC08M039049 GC08M039330 GC08M039427 GC08M037840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADAM3A Gene: 
ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with ADAM3A include composite lymphoma, and addison's disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM3A gene promoter:
         Nkx3-1 v4   LHX3b/Lhx3b   GATA-3   Nkx2-5   GATA-1   GATA-2   Nkx6-1   POU2F1   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADAM3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.22

ADAM3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM3A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M039325:  view genomic region     (about GC identifiers)

Start:
39,308,564 bp from pter      End:
39,380,470 bp from pter
Size:
71,907 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ADAM3A

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ADAM: ADAM metallopeptidase domain containing

IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM3 
ADAM

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for ADAM3A:
a disintegrin and metalloprotease (inactive) domain 3A,cyritestin 1,membrane anchored cell surface adhesion
protein and soluble form,expressed in the acrosome region of spermatids and spermatozoa,involved in sperm-egg
fusion during fertilization

Phenotypes:
     1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Adam3):
 reproductive system 

ADAM3A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for ADAM3A: Adam3tm1(KOMP)Wtsi Adam3tm1Pmkf Adam3tm1Ihgg

   inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM3A 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM3A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAM3A

Search CenterWatch for drugs/clinical trials and news about ADAM3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for ADAM3A:

ADAM metallopeptidase domain 3A (pseudogene)
Hs.98848  [show with all ESTs]
Unigene Representative Sequence: NR_073423
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000460383 ENST00000481351(uc003xnd.3) ENST00000495171(uc010lwv.3 uc003xnf.3 uc011lcj.1)
ENST00000490268(uc003xne.3 uc011lci.2) ENST00000497806 ENST00000474764
ENST00000461344 ENST00000484602 ENST00000424066(uc003xng.4)
miRNA
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Additional mRNA sequence: 

AJ005372.1 AK302269.1 AK308250.1 BC025386.1 BC042979.2 NR_001569.3 NR_024106.2 NR_024107.2 
NR_073423.1 X89654.1 X89655.1 X89656.1 X89657.1 

7 DOTS entries:

DT.101960107  DT.120643912  DT.120643907  DT.87046220  DT.97825764  DT.95267429  DT.95287572 

24/31 AceView cDNA sequences (see all 31):

BI459199 X89657 BM908226 BI459404 X89655 BI463148 AA435963 BI827962 
BX090069 AA421339 BV204640 X89654 X89656 AJ005372 BC042979 BG721794 
BG720012 BC025386 AA421475 BG717260 BI828828 BI829329 BI559377 NR_001569 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM3A (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:                                                                                                                    -                                       
SP2:                                                                                                                                                            
SP3:                                                                                                              -     -     -                                 
SP4:                                                  -           -     -                                                                                       
SP5:                                      -           -     -     -     -                                                                                       

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:                        
SP2:                        
SP3:                        
SP4:                        
SP5:                        


ECgene alternative splicing isoforms for ADAM3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAM3A expression in normal human tissues (normalized intensities)      ADAM3A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ADAM3A Expression
About this image


ADAM3A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Testis (Reproductive System)    fully expand to see all 2 entries
         Spermatozoan Seminiferous Tubules
         sperm   
 
 Gonad
         Spermatozoan Seminiferous Tubules
 
 Pancreas (Endocrine System)
 
 Epidermis (Integumentary System)
 
 Dermis (Integumentary System)

Genevestigator expression for ADAM3A

SOURCE GeneReport for Unigene cluster: Hs.98848
    SABiosciences Custom PCR Arrays for ADAM3A
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ADAM3A gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adam35 a disintegrin and metallopeptidase domain 3 (cyritestin)   --   8 (13.09 cM) 24677225 


ENSEMBL Gene Tree for ADAM3A (if available)
TreeFam Gene Tree for ADAM3A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1531 SNPs in ADAM3A are shown (see all 1531)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs69843291,2
C,F,A--39308393(+) cgaacG/Aggtga 4 -- int18Minor allele frequency- A:0.45NA WA CSA EA 367
rs1921628611,2
--39308405(+) CCACTC/TCCCTG 4 -- int10--------
rs743299201,2
C,F--39308428(+) TGAGGG/AAGATC 4 -- int12Minor allele frequency- A:0.15NA EA 240
rs1424489151,2
--39308433(+) GAGATC/TAGTGA 4 -- int10--------
rs1855772821,2
--39308505(+) ACAAAG/TCCGCT 4 -- int10--------
rs74630191,2
C,F,A,H--39308621(+) TTAATA/C/GGTGAG 8 -- nc-transcript-variantese312NS NA WA CSA EA 488
rs752602471,2
C,F--39308676(+) CACTTG/CGTTAC 4 -- nc-transcript-variant2Minor allele frequency- C:0.18NA EA 240
rs78370851,2
C,F,H--39309170(+) CCCCTC/TCACTT 4 -- int114Minor allele frequency- T:0.06NS EA WA NA 1882
rs598087841,2
--39309233(+) AAAAGC/GTGTCA 4 -- int10--------
rs119906841,2
C,F,H--39309302(+) TAAACG/ATCCAT 4 -- int11Minor allele frequency- A:0.33NA 6

HapMap Linkage Disequilibrium report for ADAM3A (39308564 - 39380470 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/59 variations for ADAM3A (see all 59):    About this table     
Variant IDTypeSubtypePubMed ID
dgv1282e199CNV Deletion23128226
esv2421469CNV Deletion20811451
esv2736900CNV Deletion23290073
esv2736901CNV Deletion23290073
nsv820723CNV Deletion20802225
esv995573CNV Deletion20482838
nsv433493CNV Loss18776910
dgv7768n71CNV Loss21882294
dgv7782n71CNV Loss21882294
nsv508503CNV Loss20534489

SABiosciences Cancer Mutation PCR Assays
1 SABiosciences qBiomarker Copy Number PCR Array containing ADAM3A:
Glioma
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for ADAM3A:    About MalaCards
composite lymphoma    addison's disease

1 disease from the University of Copenhagen DISEASES database for ADAM3A:
Composite lymphoma

ADAM3A for disorders           About GeneDecksing


Export disorders for ADAM3A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ADAM3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM3A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. (PubMed id 11439107)1, 3, 9 Grzmil P....Engel W. (2001)
  2. Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction. (PubMed id 9502432)1, 3, 9 Adham I.M....Engel W. (1998)
  3. Homozygous loss of ADAM3A revealed by genome-wide ana lysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. (PubMed id 21138945)1 Barrow J....Grundy R. (2011)
  4. Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (2010)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. The gene for the human tMDC I sperm surface protein is non-functional: implications for its proposed role in mammalian sperm-egg recognition. (PubMed id 9693117)1 Frayne J. and Hall L. (1998)
  8. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. (PubMed id 16157606)9 Yang Z.F....Fan S.T. (2005)
  9. Identification and characterization of ADAM32 with testis-predominant gene expression. (PubMed id 12568724)9 Choi I.... Cho C. (2003)
  10. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PubMed id 12206465)9 Evans J.P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1587 HGNC: 209 AceView: ADAM3A Ensembl:ENSG00000197475 euGenes: HUgn1587
ECgene: ADAM3A H-InvDB: ADAM3A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ADAM3A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ADAM3A gene:
Search GeneIP for patents involving ADAM3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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