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Aliases for ADAM3A Gene

Aliases for ADAM3A Gene

  • ADAM Metallopeptidase Domain 3A (Pseudogene) 2 3
  • A Disintegrin And Metalloproteinase Domain 3a (Cyritestin 1) 2 3
  • ADAM Metallopeptidase Domain 3A, Pseudogene 2 3
  • Cyritestin 1 2 3
  • ADAM Metallopeptidase Domain 3A 2
  • ADAM3 3
  • TMDCI 3
  • CYRN1 3

External Ids for ADAM3A Gene

Previous HGNC Symbols for ADAM3A Gene

  • CYRN1

Previous GeneCards Identifiers for ADAM3A Gene

  • GC08U990016
  • GC08M039049
  • GC08M039330
  • GC08M039325
  • GC08M037840

Summaries for ADAM3A Gene

GeneCards Summary for ADAM3A Gene

ADAM3A (ADAM Metallopeptidase Domain 3A (Pseudogene)) is a Pseudogene. Diseases associated with ADAM3A include composite lymphoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM3A Gene

Genomics for ADAM3A Gene

Regulatory Elements for ADAM3A Gene

Genomic Location for ADAM3A Gene

Start:
39,451,045 bp from pter
End:
39,522,989 bp from pter
Size:
71,945 bases
Orientation:
Minus strand

Genomic View for ADAM3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM3A Gene

Proteins for ADAM3A Gene

Post-translational modifications for ADAM3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAM3A Gene

Domains for ADAM3A Gene

Gene Families for ADAM3A Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM3A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ADAM3A Gene

Function for ADAM3A Gene

Molecular function for ADAM3A Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease (inactive) domain 3A,cyritestin 1,membrane anchored cell surface adhesion protein and soluble form,expressed in the acrosome region of spermatids and spermatozoa,involved in sperm-egg fusion during fertilization

Phenotypes for ADAM3A Gene

MGI mutant phenotypes for ADAM3A:
inferred from 3 alleles
genes like me logo Genes that share phenotypes with ADAM3A: view

Animal Models for ADAM3A Gene

MGI Knock Outs for ADAM3A:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM3A Gene

Localization for ADAM3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM3A Gene COMPARTMENTS Subcellular localization image for ADAM3A gene
Compartment Confidence
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADAM3A Gene

Pathways for ADAM3A Gene

SuperPathways for ADAM3A Gene

No Data Available

Interacting Proteins for ADAM3A Gene

Gene Ontology (GO) - Biological Process for ADAM3A Gene

None

No data available for Pathways by source for ADAM3A Gene

Transcripts for ADAM3A Gene

Unigene Clusters for ADAM3A Gene

ADAM metallopeptidase domain 3A (pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM3A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: -

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ADAM3A Gene

GeneLoc Exon Structure for
ADAM3A
ECgene alternative splicing isoforms for
ADAM3A

Expression for ADAM3A Gene

mRNA expression in normal human tissues for ADAM3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM3A Gene

This gene is overexpressed in Testis (52.7).

SOURCE GeneReport for Unigene cluster for ADAM3A Gene Hs.98848

genes like me logo Genes that share expressions with ADAM3A: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for ADAM3A Gene

Orthologs for ADAM3A Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ADAM3A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Adam3 16
Species with no ortholog for ADAM3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM3A Gene

ENSEMBL:
Gene Tree for ADAM3A (if available)
TreeFam:
Gene Tree for ADAM3A (if available)

Paralogs for ADAM3A Gene

No data available for Paralogs for ADAM3A Gene

Variants for ADAM3A Gene

Sequence variations from dbSNP and Humsavar for ADAM3A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1132224 -- 39,492,007(-) CGATA(C/T)GATCC nc-transcript-variant
rs4076606 -- 39,471,431(+) ccgtg(C/G)ttcag intron-variant
rs4130307 -- 39,458,909(+) AGCTA(C/G)TTTAA intron-variant
rs6474148 -- 39,471,611(+) aactt(C/T)cctcc intron-variant
rs6474149 -- 39,472,072(+) attta(C/T)ggcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM3A Gene

Variant ID Type Subtype PubMed ID
nsv428198 CNV Gain 18775914
dgv2227e1 CNV Complex 17122850
dgv2228e1 CNV Complex 17122850
dgv2229e1 CNV Complex 17122850
dgv7765n71 CNV Gain+Loss 21882294
dgv7766n71 CNV Loss 21882294
dgv7767n71 CNV Gain 21882294
dgv7768n71 CNV Loss 21882294
nsv890725 CNV Gain 21882294
dgv7769n71 CNV Loss 21882294
nsv527334 CNV Loss 19592680
dgv7770n71 CNV Gain 21882294
dgv146n17 CNV Loss 16327808
nsv508503 CNV Loss 20534489
nsv6163 CNV Loss 18451855
nsv820723 CNV Deletion 20802225
dgv1179n67 CNV Loss 20364138
nsv819496 CNV Gain 19587683
esv995573 CNV Deletion 20482838
dgv1282e199 CNV Deletion 23128226
dgv7772n71 CNV Gain+Loss 21882294
nsv890760 CNV Gain+Loss 21882294
esv21867 CNV Gain+Loss 19812545
nsv8331 CNV Gain+Loss 18304495
esv2736900 CNV Deletion 23290073
dgv181e180 CNV Loss 20482838
esv32816 CNV Loss 17666407
nsv433493 CNV Loss 18776910
esv2421469 CNV Deletion 20811451
nsv438050 CNV Loss 16468122
nsv515081 CNV Loss 21397061
dgv7773n71 CNV Loss 21882294
nsv442511 CNV CNV 18776908
nsv890774 CNV Gain 21882294
nsv511391 CNV Gain 21212237
dgv2230e1 CNV Complex 17122850
dgv2231e1 CNV Complex 17122850
dgv7774n71 CNV Loss 21882294
dgv7775n71 CNV Loss 21882294
nsv890806 CNV Gain+Loss 21882294
dgv2232e1 CNV Complex 17122850
dgv7776n71 CNV Gain 21882294
dgv7777n71 CNV Gain+Loss 21882294
dgv7778n71 CNV Gain 21882294
nsv890812 CNV Gain+Loss 21882294
nsv831297 CNV Gain 17160897
nsv433247 CNV Loss 18776910
dgv7779n71 CNV Gain+Loss 21882294
dgv147n17 CNV Loss 16327808
dgv7780n71 CNV Gain 21882294
nsv890825 CNV Gain 21882294
nsv890826 CNV Loss 21882294
esv2736901 CNV Deletion 23290073
nsv824608 CNV Gain 20364138
nsv824610 CNV Loss 20364138
dgv7781n71 CNV Loss 21882294
dgv7782n71 CNV Loss 21882294
dgv7783n71 CNV Loss 21882294
nsv824611 CNV Gain 20364138

Relevant External Links for ADAM3A Gene

HapMap Linkage Disequilibrium report
ADAM3A

PCR Panel Products

  • Copy Number PCR Panels: for ADAM3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM3A Gene

Disorders for ADAM3A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADAM3A Gene including...

Search for ADAM3A Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADAM3A Gene

genes like me logo Genes that share disorders with ADAM3A: view

No data available for UniProtKB/Swiss-Prot for ADAM3A Gene

Publications for ADAM3A Gene

  1. Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction. (PMID: 9502432) Adham I.M. … Engel W. (DNA Cell Biol. 1998) 2 3 23
  2. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. (PMID: 11439107) Grzmil P. … Engel W. (Biochem. J. 2001) 2 3 23
  3. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PMID: 12206465) Evans J.P. (Hum. Reprod. Update 2002) 23
  4. Identification and characterization of ADAM32 with testis-predominant gene expression. (PMID: 12568724) Choi I. … Cho C. (Gene 2003) 23
  5. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. (PMID: 16157606) Yang Z.F. … Fan S.T. (Int. Immunol. 2005) 23

Products for ADAM3A Gene

Sources for ADAM3A Gene

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