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Aliases for ADAM3A Gene

Aliases for ADAM3A Gene

  • ADAM Metallopeptidase Domain 3A (Pseudogene) 2 3 5
  • A Disintegrin And Metalloproteinase Domain 3a (Cyritestin 1) 2 3
  • Cyritestin 1 2 3
  • ADAM Metallopeptidase Domain 3A, Pseudogene 2
  • ADAM Metallopeptidase Domain 3A 2
  • ADAM3 3
  • TMDCI 3
  • CYRN1 3

External Ids for ADAM3A Gene

Previous HGNC Symbols for ADAM3A Gene

  • CYRN1

Previous GeneCards Identifiers for ADAM3A Gene

  • GC08U990016
  • GC08M039049
  • GC08M039330
  • GC08M039325
  • GC08M037840

Summaries for ADAM3A Gene

GeneCards Summary for ADAM3A Gene

ADAM3A (ADAM Metallopeptidase Domain 3A (Pseudogene)) is a Pseudogene. Diseases associated with ADAM3A include Conjunctival Squamous Cell Carcinoma.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM3A Gene

Genomics for ADAM3A Gene

Regulatory Elements for ADAM3A Gene

Enhancers for ADAM3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G039581 0.6 ENCODE 8.1 -59.0 -58969 1.8 PKNOX1 TAL1 TCF12 ARID1B NCOR1 SMARCA4 PBX2 KDM1A FOXP2 ADAM5 LOC100130964 ADAM3A ADAM18 GC08P039555
GH08G039534 0.8 ENCODE 0.4 -12.2 -12237 1.1 HDAC1 LEF1 TAL1 TCF12 FOXM1 NCOR1 NR2F6 TRIM24 SMARCE1 MTA2 ADAM3A GC08P039555
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM3A on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM3A Gene

Chromosome:
8
Start:
39,451,045 bp from pter
End:
39,522,989 bp from pter
Size:
71,945 bases
Orientation:
Minus strand

Genomic View for ADAM3A Gene

Genes around ADAM3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM3A Gene

Proteins for ADAM3A Gene

Post-translational modifications for ADAM3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAM3A Gene

Domains & Families for ADAM3A Gene

Gene Families for ADAM3A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM3A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ADAM3A Gene

Function for ADAM3A Gene

Molecular function for ADAM3A Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (inactive) domain 3A,cyritestin 1,membrane anchored cell surface adhesion protein and soluble form,expressed in the acrosome region of spermatids and spermatozoa,involved in sperm-egg fusion during fertilization

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM3A Gene

Localization for ADAM3A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADAM3A Gene

Pathways & Interactions for ADAM3A Gene

SuperPathways for ADAM3A Gene

No Data Available

Interacting Proteins for ADAM3A Gene

Gene Ontology (GO) - Biological Process for ADAM3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADAM3A Gene

Drugs & Compounds for ADAM3A Gene

No Compound Related Data Available

Transcripts for ADAM3A Gene

Unigene Clusters for ADAM3A Gene

ADAM metallopeptidase domain 3A (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: -

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ADAM3A Gene

GeneLoc Exon Structure for
ADAM3A
ECgene alternative splicing isoforms for
ADAM3A

Expression for ADAM3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM3A Gene

mRNA differential expression in normal tissues according to GTEx for ADAM3A Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of ADAM3A Gene:

ADAM3A

SOURCE GeneReport for Unigene cluster for ADAM3A Gene:

Hs.98848
genes like me logo Genes that share expression patterns with ADAM3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM3A Gene

Orthologs for ADAM3A Gene

Evolution for ADAM3A Gene

ENSEMBL:
Gene Tree for ADAM3A (if available)
TreeFam:
Gene Tree for ADAM3A (if available)

No data available for Orthologs for ADAM3A Gene

Paralogs for ADAM3A Gene

No data available for Paralogs for ADAM3A Gene

Variants for ADAM3A Gene

Sequence variations from dbSNP and Humsavar for ADAM3A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000021991 -- 39,497,185(+) GATTC(A/G)ACAGT intron-variant
rs1000176122 -- 39,486,379(+) ATCTA(C/T)TTAGT intron-variant
rs1000294751 -- 39,497,365(+) ATCTC(-/TT)TGTGC intron-variant
rs1000382711 -- 39,454,045(+) TTTAC(A/G)TCACC intron-variant
rs1000383259 -- 39,478,111(+) CTTTA(C/T)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM3A Gene

Variant ID Type Subtype PubMed ID
dgv1179n67 CNV loss 20364138
dgv12091n54 CNV gain 21841781
dgv12092n54 CNV loss 21841781
dgv12093n54 CNV gain 21841781
dgv12094n54 CNV gain+loss 21841781
dgv12095n54 CNV loss 21841781
dgv12096n54 CNV loss 21841781
dgv12102n54 CNV gain+loss 21841781
dgv12103n54 CNV loss 21841781
dgv12104n54 CNV gain 21841781
dgv12105n54 CNV loss 21841781
dgv12106n54 CNV gain+loss 21841781
dgv12107n54 CNV loss 21841781
dgv12108n54 CNV loss 21841781
dgv12109n54 CNV loss 21841781
dgv12110n54 CNV loss 21841781
dgv12111n54 CNV loss 21841781
dgv1282e199 CNV deletion 23128226
dgv146n17 CNV loss 16327808
dgv147n17 CNV loss 16327808
dgv181e180 CNV loss 20482838
dgv2066e212 CNV gain 25503493
dgv2067e212 CNV gain 25503493
dgv2068e212 CNV loss 25503493
dgv266n111 CNV deletion 26073780
dgv35e209 CNV deletion 24192839
dgv3807n106 CNV deletion 24896259
dgv67e213 CNV loss 24956385
dgv7166n100 CNV gain 25217958
dgv7167n100 CNV gain 25217958
dgv7169n100 CNV gain 25217958
dgv7170n100 CNV gain+loss 25217958
dgv7171n100 CNV loss 25217958
dgv7173n100 CNV gain+loss 25217958
dgv7174n100 CNV loss 25217958
dgv7175n100 CNV gain 25217958
dgv7176n100 CNV loss 25217958
dgv7177n100 CNV gain 25217958
dgv7178n100 CNV loss 25217958
dgv7179n100 CNV gain+loss 25217958
dgv7180n100 CNV gain 25217958
dgv7181n100 CNV loss 25217958
dgv7182n100 CNV loss 25217958
esv21867 CNV gain+loss 19812545
esv2421469 CNV deletion 20811451
esv2736900 CNV deletion 23290073
esv2736901 CNV deletion 23290073
esv2759608 CNV gain+loss 17122850
esv2761164 CNV loss 21179565
esv2764074 CNV gain+loss 21179565
esv32816 CNV loss 17666407
esv3543387 CNV deletion 23714750
esv3572691 CNV loss 25503493
esv3572692 CNV loss 25503493
esv3572693 CNV loss 25503493
esv3616947 CNV loss 21293372
esv3616950 CNV loss 21293372
esv3616951 CNV loss 21293372
esv3891382 CNV loss 25118596
esv3891383 CNV loss 25118596
esv3891384 CNV loss 25118596
esv995573 CNV deletion 20482838
nsv1021473 CNV gain 25217958
nsv1024969 CNV gain 25217958
nsv1074232 CNV deletion 25765185
nsv1115089 CNV deletion 24896259
nsv428198 CNV gain 18775914
nsv433247 CNV loss 18776910
nsv433493 CNV loss 18776910
nsv438050 CNV loss 16468122
nsv442511 CNV loss 18776908
nsv508503 CNV deletion 20534489
nsv511391 CNV gain 21212237
nsv515081 CNV loss 21397061
nsv527334 CNV loss 19592680
nsv610958 CNV gain 21841781
nsv611048 CNV gain 21841781
nsv611049 CNV gain+loss 21841781
nsv611050 CNV loss 21841781
nsv611053 CNV gain 21841781
nsv611064 CNV loss 21841781
nsv611067 CNV loss 21841781
nsv611072 CNV gain+loss 21841781
nsv611083 CNV gain+loss 21841781
nsv611084 CNV gain 21841781
nsv611085 CNV loss 21841781
nsv6163 CNV deletion 18451855
nsv819496 CNV gain 19587683
nsv820723 CNV deletion 20802225
nsv824608 CNV gain 20364138
nsv824610 CNV loss 20364138
nsv824611 CNV gain 20364138
nsv831297 CNV gain 17160897
nsv8331 CNV gain+loss 18304495
nsv951129 CNV deletion 24416366

Relevant External Links for ADAM3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ADAM3A Gene

Disorders for ADAM3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM3A Gene - From: GeneCards

Disorder Aliases PubMed IDs
conjunctival squamous cell carcinoma
  • conjunctival epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAM3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM3A
genes like me logo Genes that share disorders with ADAM3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM3A Gene

Publications for ADAM3A Gene

  1. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. (PMID: 11439107) Grzmil P. … Engel W. (Biochem. J. 2001) 2 3 22 64
  2. Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction. (PMID: 9502432) Adham I.M. … Engel W. (DNA Cell Biol. 1998) 2 3 22 64
  3. A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts. (PMID: 25776870) Younkin S.G. … Ruczinski I. (Birth Defects Res. Part A Clin. Mol. Teratol. 2015) 3 64
  4. Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population. (PMID: 25201121) Han J. … Hao L. (Cell. Physiol. Biochem. 2014) 3 64
  5. Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma. (PMID: 25491297) Asnaghi L. … Eberhart C.G. (Invest. Ophthalmol. Vis. Sci. 2014) 3 64

Products for ADAM3A Gene

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