ADAM3A Gene

Aliases
for ADAM3A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC08U990016 GC08M039049 GC08M039330 GC08M039427 GC08M037840

Summaries
for ADAM3A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ADAM3A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000008.10  NT_167187.2  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM3A

ADAM3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M039325:  view genomic region     (about GC identifiers)

Proteins
for ADAM3A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Domains /
Families
for ADAM3A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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Function
for ADAM3A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Localization
for ADAM3A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for ADAM3A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for ADAM3A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ADAM3A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for ADAM3A:

miRNA Products:		Block miRNA regulation of human, mouse, rat ADAM3A using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ADAM3A
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse OriGene RNAi
		Predesigned siRNA for gene silencing in human, mouse, rat ADAM3A

Clone Products:		OriGene clones in human, mouse for ADAM3A OriGene ORF clones in mouse, rat for ADAM3A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for ADAM3A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM3A
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAM3A

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ADAM3A
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ADAM3A
		Search QuantiTect SYBR Green Assays in human, mouse, rat ADAM3A
		Search QuantiFast Probe-based Assays in human, mouse, rat ADAM3A

Additional mRNA sequence: 

7 DOTS entries:

Selected AceView cDNA sequences (see all 31):

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM3A (see all 7)    About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^
SP1:																																							-
SP2:
SP3:																																					-		-		-
SP4:																	-				-		-
SP5:													-				-		-		-		-

ExUns:	19	^	20	^	21	^	22
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ADAM3A

Expression
for ADAM3A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADAM3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Testis (Reproductive System)    fully expand to see all 2 entries
Spermatozoan Seminiferous Tubules
Gonad
Spermatozoan Seminiferous Tubules
Pancreas (Endocrine System)
Dermis (Integumentary System)

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ADAM3A
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ADAM3A
		Search QuantiTect SYBR Green Assays in human, mouse, rat ADAM3A
		Search QuantiFast Probe-based Assays in human, mouse, rat ADAM3A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM3A

Orthologs
for ADAM3A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ADAM3A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for ADAM3A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ADAM3A (see all 1531)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs69843291,2	C,F,A	--	39308393(+)	cgaacG/Aggtga	4	--	int1		8		NA WA CSA EA	367
rs1921628611,2		--	39308405(+)	CCACTC/TCCCTG	4	--	int1		0	--	--	--	--
rs743299201,2	C,F	--	39308428(+)	TGAGGG/AAGATC	4	--	int1		2		NA EA	240
rs1424489151,2		--	39308433(+)	GAGATC/TAGTGA	4	--	int1		0	--	--	--	--
rs1855772821,2		--	39308505(+)	ACAAAG/TCCGCT	4	--	int1		0	--	--	--	--
rs74630191,2	C,F,A,H	--	39308621(+)	TTAATA/C/GGTGAG	8	--	nc-transcript-variantese3		12		NS NA WA CSA EA	488
rs752602471,2	C,F	--	39308676(+)	CACTTG/CGTTAC	4	--	nc-transcript-variant		2		NA EA	240
rs78370851,2	C,F,H	--	39309170(+)	CCCCTC/TCACTT	4	--	int1		14		NS EA WA NA	1882
rs598087841,2		--	39309233(+)	AAAAGC/GTGTCA	4	--	int1		0	--	--	--	--
rs119906841,2	C,F,H	--	39309302(+)	TAAACG/ATCCAT	4	--	int1		1		NA	6

HapMap Linkage Disequilibrium report for ADAM3A (39308564 - 39380470 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ADAM3A (see all 59):    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv1282e199	CNV	Deletion	23128226
esv2421469	CNV	Deletion	20811451
esv2736900	CNV	Deletion	23290073
esv2736901	CNV	Deletion	23290073
nsv820723	CNV	Deletion	20802225
esv995573	CNV	Deletion	20482838
nsv433493	CNV	Loss	18776910
dgv7768n71	CNV	Loss	21882294
dgv7782n71	CNV	Loss	21882294
nsv508503	CNV	Loss	20534489

Site Specific Mutation Identification with PCR Assays

1 Copy Number PCR Panel containing ADAM3A: Glioma

Search QIAGEN SeqTarget long-range PCR primers for resequencing ADAM3A

DNA2.0 Custom Variant and Variant Library Synthesis for ADAM3A

Disorders / Diseases
for ADAM3A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ADAM3A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. (PubMed id 11439107)^{1, 3, 9} Grzmil P....Engel W. (Biochem. J. 2001)
2. Molecular cloning, chromosomal localization, and expression analysis of CYRN1 and CYRN2, two human genes coding for cyritestin, a sperm protein involved in gamete interaction. (PubMed id 9502432)^{1, 3, 9} Adham I.M.... Engel W. (DNA Cell Biol. 1998)
3. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. (PubMed id 21138945)¹ Barrow J....Grundy R. (Neuro-oncology 2011)
4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PubMed id 20210993)¹ Zhang Z.D....Gerstein M. (Genome Biol. 2010)
5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
7. The gene for the human tMDC I sperm surface protein is non-functional: implications for its proposed role in mammalian sperm-egg recognition. (PubMed id 9693117)¹ Frayne J. and Hall L. (Biochem. J. 1998)
8. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. (PubMed id 16157606)⁹ Yang Z.F....Fan S.T. (Int. Immunol. 2005)
9. Identification and characterization of ADAM32 with testis-predominant gene expression. (PubMed id 12568724)⁹ Choi I.... Cho C. (Gene 2003)
10. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PubMed id 12206465)⁹ Evans J.P. (Hum. Reprod. Update 2002)

External Searches for ADAM3A gene

Genome Databases showing ADAM3A gene

Other Databases showing ADAM3A gene

Specialized Databases showing ADAM3A gene

Products
for ADAM3A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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