Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAM33 Gene

Aliases for ADAM33 Gene

  • ADAM Metallopeptidase Domain 33 2 3 5
  • A Disintegrin And Metalloproteinase Domain 33 2 3
  • C20orf153 3 4
  • ADAM 33 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 33 3
  • Disintegrin And Reprolysin Metalloproteinase Family Protein 3
  • Chromosome 20 Open Reading Frame 153 2
  • A Disintegrin And Metalloprotease 33 3
  • EC 3.4.24.- 4
  • DJ964F7.1 3

External Ids for ADAM33 Gene

Previous HGNC Symbols for ADAM33 Gene

  • C20orf153

Previous GeneCards Identifiers for ADAM33 Gene

  • GC20M003637
  • GC20M003643

Summaries for ADAM33 Gene

Entrez Gene Summary for ADAM33 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for ADAM33 Gene

ADAM33 (ADAM Metallopeptidase Domain 33) is a Protein Coding gene. Diseases associated with ADAM33 include Allergic Asthma and Asthma. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM19.

Gene Wiki entry for ADAM33 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM33 Gene

Genomics for ADAM33 Gene

Regulatory Elements for ADAM33 Gene

Enhancers for ADAM33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G003676 1.4 FANTOM5 ENCODE 24.2 +2.5 2513 6.1 PKNOX1 FOXA2 ATF1 MLX SIN3A ARID4B YBX1 ZNF48 GLIS2 ZNF207 ADAM33 HSPA12B SIGLEC1 CENPB GFRA4
GH20G003686 1.1 Ensembl ENCODE 12.1 -4.8 -4842 1.8 CTCF USF1 SUZ12 ZNF76 MAX CEBPG ZIC2 ETS1 RBAK NFYB ADAM33 SIGLEC1
GH20G003710 1.5 FANTOM5 Ensembl ENCODE 8.3 -29.5 -29455 3.0 RB1 YBX1 PLRG1 DNMT3B ZNF2 ZNF48 RAD21 SLC30A9 GLIS2 EGR1 ADAM33 C20orf27 PANK2 RNF24 SIGLEC1
GH20G003726 1.1 Ensembl ENCODE 4.9 -45.6 -45550 1.7 KLF1 ZNF76 KLF17 ZNF316 ZNF366 ZNF600 PRDM10 KLF8 MAFK ZBTB20 ADAM33 HSPA12B SIGLEC1
GH20G003669 0.7 ENCODE 6.1 +10.9 10855 2.8 CTCF KLF1 SUZ12 NFIB TAL1 RBBP5 TCF12 GLIS2 NCOR1 EZH2 SPEF1 ADAM33 GFRA4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM33 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133796 146 201 SUZ12 POLR2A NR3C1 RBBP5 YBX1 EZH2

Genomic Location for ADAM33 Gene

Chromosome:
20
Start:
3,667,965 bp from pter
End:
3,682,246 bp from pter
Size:
14,282 bases
Orientation:
Minus strand

Genomic View for ADAM33 Gene

Genes around ADAM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM33 Gene

Proteins for ADAM33 Gene

  • Protein details for ADAM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ11-ADA33_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 33
    Protein Accession:
    Q9BZ11
    Secondary Accessions:
    • A0A1K6
    • Q5JT75
    • Q5JT76
    • Q8N0W6

    Protein attributes for ADAM33 Gene

    Size:
    813 amino acids
    Molecular mass:
    87739 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADAM33 Gene

    Alternative splice isoforms for ADAM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM33 Gene

Post-translational modifications for ADAM33 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn109, posLast=145145, posLast=231231, Asn276, and Asn448
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ADAM33
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADAM33

No data available for DME Specific Peptides for ADAM33 Gene

Domains & Families for ADAM33 Gene

Gene Families for ADAM33 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZ11

UniProtKB/Swiss-Prot:

ADA33_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM33: view

Function for ADAM33 Gene

Enzyme Numbers (IUBMB) for ADAM33 Gene

Gene Ontology (GO) - Molecular Function for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 11814695
GO:0005515 protein binding IPI --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view
genes like me logo Genes that share phenotypes with ADAM33: view

Animal Models for ADAM33 Gene

MGI Knock Outs for ADAM33:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM33

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM33 Gene

Localization for ADAM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM33 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM33 gene
Compartment Confidence
plasma membrane 3
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

Pathways & Interactions for ADAM33 Gene

SuperPathways for ADAM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM33 Gene

Drugs & Compounds for ADAM33 Gene

No Compound Related Data Available

Transcripts for ADAM33 Gene

Unigene Clusters for ADAM33 Gene

ADAM metallopeptidase domain 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM33 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13:
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: -
SP17:
SP18: -
SP19:

ExUns: 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: - - - - -
SP16:
SP17: -
SP18:
SP19:

Relevant External Links for ADAM33 Gene

GeneLoc Exon Structure for
ADAM33
ECgene alternative splicing isoforms for
ADAM33

Expression for ADAM33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ADAM33 Gene:

ADAM33

SOURCE GeneReport for Unigene cluster for ADAM33 Gene:

Hs.173716

mRNA Expression by UniProt/SwissProt for ADAM33 Gene:

Q9BZ11-ADA33_HUMAN
Tissue specificity: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.

Evidence on tissue expression from TISSUES for ADAM33 Gene

  • Lung(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ADAM33: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM33 Gene

Orthologs for ADAM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM33 34 35
  • 97.95 (n)
dog
(Canis familiaris)
Mammalia ADAM33 34 35
  • 82.96 (n)
cow
(Bos Taurus)
Mammalia ADAM33 34 35
  • 81.85 (n)
mouse
(Mus musculus)
Mammalia Adam33 34 16 35
  • 78.67 (n)
rat
(Rattus norvegicus)
Mammalia Adam33 34
  • 78.62 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM33 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM33 34 35
  • 66.97 (n)
lizard
(Anolis carolinensis)
Reptilia ADAM33 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam33 34
  • 60.01 (n)
zebrafish
(Danio rerio)
Actinopterygii adam19a 34 35
  • 60.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta mmd 36
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for ADAM33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM33 Gene

ENSEMBL:
Gene Tree for ADAM33 (if available)
TreeFam:
Gene Tree for ADAM33 (if available)

Paralogs for ADAM33 Gene

genes like me logo Genes that share paralogs with ADAM33: view

Variants for ADAM33 Gene

Sequence variations from dbSNP and Humsavar for ADAM33 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_066337 A cutaneous metastatic melanoma sample
rs1000021117 -- 3,678,930(+) AGAGC(A/G)TCCTG intron-variant
rs1000061936 -- 3,682,961(+) CCACC(C/T)CCAGC upstream-variant-2KB
rs1000183200 -- 3,669,217(+) TGATT(-/A)GGGGG intron-variant
rs1000191147 -- 3,678,051(+) GGAGC(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM33 Gene

Variant ID Type Subtype PubMed ID
esv3575355 CNV gain 25503493
nsv520565 CNV loss 19592680

Variation tolerance for ADAM33 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.51; 82.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM33 Gene

Human Gene Mutation Database (HGMD)
ADAM33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM33 Gene

Disorders for ADAM33 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADAM33 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic asthma
  • atopic asthma
asthma
  • asthma, protection against
bronchial disease
  • bronchospasm
pulmonary disease, chronic obstructive
  • copd, rate of decline of lung function in
respiratory system disease
  • respiration disorders
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA33_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:12110844, ECO:0000269 PubMed:16773130, ECO:0000269 PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ADAM33

Genetic Association Database (GAD)
ADAM33
Human Genome Epidemiology (HuGE) Navigator
ADAM33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM33
genes like me logo Genes that share disorders with ADAM33: view

No data available for Genatlas for ADAM33 Gene

Publications for ADAM33 Gene

  1. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. (PMID: 12110844) Van Eerdewegh P. … Keith T.P. (Nature 2002) 3 4 22 46 64
  2. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PMID: 19237393) Blakey J.D. … Hall I.P. (Thorax 2009) 3 4 46 64
  3. Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population. (PMID: 18752037) Zhang X. … Zhang J. (Mol. Biol. Rep. 2009) 3 22 46 64
  4. Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. (PMID: 20003279) Wang X. … Lv F. (BMC Med. Genet. 2009) 3 22 46 64
  5. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. (PMID: 18778489) Su D. … Zhang J. (BMC Med. Genet. 2008) 3 22 46 64

Products for ADAM33 Gene

Sources for ADAM33 Gene

Content
Loading form....