Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADAM33 Gene

protein-coding   GIFtS: 61
GCID: GC20M003596

ADAM Metallopeptidase Domain 33

(Previous names: a disintegrin and metalloproteinase domain 33, chromosome...)
(Previous symbol: C20orf153)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADAM Metallopeptidase Domain 331 2     DJ964F7.12
C20orf1531 2 3     A Disintegrin And Metalloprotease 332
A Disintegrin And Metalloproteinase Domain 331 2     Disintegrin And Metalloproteinase Domain-Containing Protein 332
ADAM 332 3     Disintegrin And Reprolysin Metalloproteinase Family Protein2
Chromosome 20 Open Reading Frame 1531     EC 3.4.24.-3

External Ids:    HGNC: 154781   Entrez Gene: 803322   Ensembl: ENSG000001494517   OMIM: 6071145   UniProtKB: Q9BZ113   

Export aliases for ADAM33 gene to outside databases

Previous GC identifers: GC20M003637 GC20M003643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADAM33 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial
hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Sep 2013)

GeneCards Summary for ADAM33 Gene:
ADAM33 (ADAM metallopeptidase domain 33) is a protein-coding gene. Diseases associated with ADAM33 include asthma, and allergic asthma. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM7.

Gene Wiki entry for ADAM33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM33 gene promoter:
         GR   GR-beta   p300   C/EBPalpha   E47   CHOP-10   PPAR-gamma1   STAT3   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAM33 promoter sequence
   Search Chromatin IP Primers for ADAM33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

ADAM33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM33 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003596:  view genomic region     (about GC identifiers)

Start:
3,648,612 bp from pter      End:
3,662,893 bp from pter
Size:
14,282 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADA33_HUMAN, Q9BZ11 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 33 precursor  
Size: 813 amino acids; 87739 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
2 PDB 3D structures from and Proteopedia for ADAM33:
1R54 (3D)        1R55 (3D)    
Secondary accessions: A0A1K6 Q5JT75 Q5JT76 Q8N0W6
Alternative splicing: 3 isoforms:  Q9BZ11-1   Q9BZ11-2   Q9BZ11-3   (No experimental confirmation available. By similarity with mouse isoform)

Explore the universe of human proteins at neXtProt for ADAM33: NX_Q9BZ11

Explore proteomics data for ADAM33 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn109, Asn145, Asn231, Asn276, Asn448
  • Modification sites at PhosphoSitePlus

  • See ADAM33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269376.1  NP_079496.1  NP_694882.1  

    ENSEMBL proteins: 
     ENSP00000348912   ENSP00000369190   ENSP00000322550  

    ADAM33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAM33
    GenScript Custom Purified and Recombinant Proteins Services for ADAM33
    Novus Biologicals ADAM33 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM33

    ADAM33 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ADAM33
    OriGene Antibodies for ADAM33
    OriGene Custom Antibody Services for ADAM33
    Novus Biologicals ADAM33 Antibodies
    Abcam antibodies for ADAM33
    Cloud-Clone Corp. Antibodies for ADAM33
    ThermoFisher Antibodies for ADAM33
    LSBio Antibodies in human, mouse, rat for ADAM33

    ADAM33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM33
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAM33
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAM33
    Cloud-Clone Corp. CLIAs for ADAM33


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM33
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry Q9BZ11

    ProtoNet protein and cluster: Q9BZ11

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA33_HUMAN, Q9BZ11
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS11814695
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS11814695
         
    ADAM33 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam33):
     no phenotypic analysis  normal 

    ADAM33 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam33tm1.1Chch for ADAM33

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM33

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADAM33:
    hsa-mir-148b-3p (MIRT019258)

    Block miRNA regulation of human, mouse, rat ADAM33 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ADAM33:
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidADAM33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAM33
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAM33

    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM33 (see all 13)
    OriGene ORF clones in mouse, rat for ADAM33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAM33 (NM_025220)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM33

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAM33
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ADA33_HUMAN, Q9BZ11: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS11814695

    ADAM33 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including ADAM33: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADAM33

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ADAM33 (Q9BZ112, 3 ENSP000003489124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2876787 I2D: score=3 STRING: ENSP00000357292
    ATXN7O152653I2D: score=1 
    MPP5ENSP000002616814STRING: ENSP00000261681
    SH3PXD2AENSP000003482154STRING: ENSP00000348215
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS11814695

    ADAM33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM33 (ADA33)

    1 DrugBank Compound for ADAM33    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADAM33 gene (3 alternative transcripts): 
    NM_001282447.1  NM_025220.3  NM_153202.2  

    Unigene Cluster for ADAM33:

    ADAM metallopeptidase domain 33
    Hs.173716  [show with all ESTs]
    Unigene Representative Sequence: AK226148
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466620(uc002wis.3) ENST00000483362(uc002wiq.1) ENST00000356518(uc002wit.3 uc002wiu.3)
    ENST00000379861(uc002wir.1) ENST00000350009(uc010gba.1 uc010gbb.1 uc002wix.1 uc010zqg.1 uc010zqh.1 uc002wiy.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADAM33 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ADAM33:
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidADAM33 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADAM33
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM33
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM33 (see all 13)
    OriGene ORF clones in mouse, rat for ADAM33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADAM33 (NM_025220)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM33
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM33
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM33
      QuantiFast Probe-based Assays in human, mouse, rat ADAM33

    Additional mRNA sequence: 

    AB055891.1 AF466287.1 AF466289.1 AK092627.1 AK095953.1 AK123015.1 AK126487.1 AK126498.1 
    AK226148.1 AK300429.1 AK304037.1 AY223850.1 AY223851.1 AY223852.1 AY223853.1 AY223854.1 
    AY223855.1 AY358314.1 BC062663.1 BC125112.1 BC125113.1 

    17 DOTS entries:

    DT.101984427  DT.97794136  DT.100665070  DT.100777324  DT.434730  DT.95227190  DT.120839396  DT.100022366 
    DT.120839384  DT.120839395  DT.100022367  DT.120839388  DT.120839376  DT.434823  DT.120839391  DT.120839397 
    DT.120839401 

    Selected AceView cDNA sequences (see all 74):

    CD632575 AF466287 AF466289 CD632564 AI537771 BM510563 AY223852 BU783941 
    NM_025220 AY223854 AW594247 AI370810 NM_153202 AW131070 AY223851 BU150601 
    AY223853 CD632594 AB055891 BV196131 AI873749 AI635622 BI826766 AX748440 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM33 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
    SP1:                                      -                 -                 -     -                                                                       -   
    SP2:                                      -                 -                 -     -                                                                       -   
    SP3:                                                                                                                                                            
    SP4:                                      -                 -                                                                                                   
    SP5:                                      -                 -                       -                 -     -     -                 -     -     -     -     -   

    ExUns: 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d
    SP1:              -                                                     -     -     -                                       
    SP2:              -                                                     -     -     -                                       
    SP3:              -                                                     -     -     -                                       
    SP4:              -                 -                                   -     -     -                                       
    SP5:  -     -     -     -     -                                               -                                             


    ECgene alternative splicing isoforms for ADAM33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADAM33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTGGCC
    ADAM33 Expression
    About this image


    ADAM33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    ADAM33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173716

    UniProtKB/Swiss-Prot: ADA33_HUMAN, Q9BZ11
    Tissue specificity: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and
    veins

        Pathway & Disease-focused RT2 Profiler PCR Array including ADAM33: 
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM33
    QuantiTect SYBR Green Assays in human, mouse, rat ADAM33
    QuantiFast Probe-based Assays in human, mouse, rat ADAM33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM33 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam331 , 5 a disintegrin and metallopeptidase domain 331, 5 78.67(n)1
    73.35(a)1
      2 (63.26 cM)5
    1107511  NM_033615.21  NP_291093.21 
     1310505915 
    chicken
    (Gallus gallus)
    Aves ADAM331 ADAM metallopeptidase domain 33 66.97(n)
    59.97(a)
      422948  NM_001082418.2  NP_001075887.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM336
    ADAM metallopeptidase domain 33
    42(a)
    1 ↔ 1
    GL343639.1(223884-274945)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377269762   -- 75.71(n)    137726976 
    zebrafish
    (Danio rerio)
    Actinopterygii adam19a1 a disintegrin and metalloproteinase domain 19a 60.34(n)
    53.57(a)
      565342  XM_005172361.1  XP_005172418.1 


    ENSEMBL Gene Tree for ADAM33 (if available)
    TreeFam Gene Tree for ADAM33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADAM33 gene
    ADAM72  ADAM192  ADAM122  ADAM302  ADAM282  ADAM292  ADAM202  ADAM212  
    ADAM92  ADAM152  ADAM82  
    11 SIMAP similar genes for ADAM33 using alignment to 7 protein entries:     ADA33_HUMAN (see all proteins):
    ADAMDEC1    ADAM19    ADAM12    ADAM23    ADAM28    ADAM15
    ADAM21    ADAM22    ADAM7    ADAM2    ADAM30

    ADAM33 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADAM33 (see all 558)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663374
    A cutaneous metastatic melanoma sample4--see VAR_0663372 A V mis40--------
    rs60844331,2
    H--3648194(+) ACTGAG/AGCAGG 2 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs413694451,2
    C,F--3648258(-) CTTCAC/TCTCGG 2 -- ds50015Minor allele frequency- T:0.01NS 156
    rs5124921,2
    C,F,H--3648322(+) TGATAT/CAGGCC 2 -- ds500114Minor allele frequency- C:0.03MN NS EA NA CSA WA 910
    rs415262471,2
    C,F--3648337(-) CAAGAG/ACTGCT 2 -- ds50015Minor allele frequency- A:0.00NS 190
    rs5126251,2
    C,F,A,H--3648378(+) AGGGAG/AGCAGG 2 -- ds500127Minor allele frequency- A:0.27MN NS EA NA WA CSA 2712
    rs27870931,2
    C,F,A,H--3648462(+) TGCCAT/CCTAGG 2 -- ds500120Minor allele frequency- C:0.16NS EA NA WA CSA 970
    rs2007839361,2
    --3648492(+) CCCCG-/TCAGCC
    ACCACCCCA
    TCAGC
    2 -- ds50010--------
    rs1486267491,2
    C--3648526(+) ACCAA-/CCACCACCCC
    GCCAACCACCAC
    CCCGT
    2 -- ds50010--------
    rs175488101,2
    C,F--3648543(+) CAACCA/C/GCCACC 2 -- ds50017NS NA EA 426

    HapMap Linkage Disequilibrium report for ADAM33 (3648612 - 3662893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAM33:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4521n71CNV Loss21882294
    nsv520565CNV Loss19592680
    nsv912615CNV Loss21882294
    nsv912616CNV Loss21882294

    Human Gene Mutation Database (HGMD): ADAM33
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM33
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607114    OMIM disorders: --

    UniProtKB/Swiss-Prot: ADA33_HUMAN, Q9BZ11
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is
    a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many
    genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal
    dyspnea, with wheezing due to spasmodic contraction of the bronchi. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • Selected diseases for ADAM33 (see all 21):    
    About MalaCards
    asthma    allergic asthma    rabies    allergic rhinitis
    atopy    rhinitis    bronchiolitis    atopic dermatitis
    glioblastoma multiforme    psoriasis    dermatitis    lymphoblastic leukemia
    type 1 diabetes    ataxia    hepatitis b    atherosclerosis
    hepatitis    melanoma    multiple myeloma    leukemia

    1 disease from the University of Copenhagen DISEASES database for ADAM33:
    Asthma

    ADAM33 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for ADAM33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 71.3 90 16387804 (8), 14564349 (5), 17208589 (4), 16839403 (4) (see all 30)
    asthma childhood 54.1 4 16784537 (2), 16650044 (2)
    asthma allergic 53.5 3 18778489 (2), 16784537 (1)
    pulmonary disease chronic obstructive 45.3 2 15879414 (1), 19797132 (1)
    airway obstruction 36.9 1 17088949 (1)
    inflammation 7.22 7 19635592 (3), 17090574 (1), 17878941 (1), 17088949 (1)

    Genetic Association Database (GAD): ADAM33
    Human Genome Epidemiology (HuGE) Navigator: ADAM33 (56 documents)

    Export disorders for ADAM33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADAM33 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with ADAM33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. (PubMed id 12110844)1, 2, 4, 9 Van Eerdewegh P.... Keith T.P. (Nature 2002)
    2. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PubMed id 19237393)1, 2, 4 Blakey J.D.... Hall I.P. (Thorax 2009)
    3. ADAM33 haplotypes are associated with asthma in a large Australian population. (PubMed id 16773130)1, 2, 4 Kedda M.A.... Thompson P.J. (Eur. J. Hum. Genet. 2006)
    4. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. (PubMed id 11814695)1, 2, 3 Yoshinaka T.... Higashiyama S. (Gene 2002)
    5. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. (PubMed id 15196271)1, 4, 9 Lee J.H....Shin H.D. (Clin. Exp. Allergy 2004)
    6. Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. (PubMed id 20003279)1, 4, 9 Wang X....Lv F. (BMC Med. Genet. 2009)
    7. Association between ADAM33 polymorphisms and asthma in a Thai population. (PubMed id 19317339)1, 4, 9 Thongngarm T....Thongnoppakhun W. (Asian Pac. J. Allergy Immunol. 2008)
    8. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. (PubMed id 16839403)1, 4, 9 Hirota T....Tamari M. (Clin. Exp. Allergy 2006)
    9. The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations. (PubMed id 16784537)1, 4, 9 Schedel M....Kabesch M. (Respir. Res. 2006)
    10. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. (PubMed id 18778489)1, 4, 9 Su D....Zhang J. (BMC Med. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80332 HGNC: 15478 AceView: ADAM33 Ensembl:ENSG00000149451 euGenes: HUgn80332
    ECgene: ADAM33 H-InvDB: ADAM33

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADAM33 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adam33/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAM33 gene:
    Search GeneIP for patents involving ADAM33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ADAM33 (ADAM33)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADAM33   OriGene RNAi products in human, mouse, rat for ADAM33  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAM33  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAM33   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAM33   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAM33   OriGene Custom Protein Services for ADAM33  

     
     
     Block miRNA regulation of human, mouse, rat ADAM33 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAM33
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM33 Predesigned siRNA for gene silencing in human, mouse, rat ADAM33
     QuantiFast Probe-based Assays in human, mouse, rat ADAM33 QuantiTect SYBR Green Assays in human, mouse, rat ADAM33
     PCR Arrays including human, mouse, rat ADAM33 Search Chromatin IP Primers for ADAM33
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM33  GeneGlobe Interaction Network for ADAM33
     Regulatory tfbs in ADAM33 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADAM33 GenScript cDNA clones with any tag delivered in your preferred vector for ADAM33
     GenScript Custom Assay Services for ADAM33 GenScript Custom overexpressing Cell Line Services for ADAM33
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ADAM33 (ADA33)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADAM33 antibodies
     ADAM33 proteins
     Antibodies for ADAM33
     See all of Abcam's Antibodies, Kits and Proteins for ADAM33
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ADAM33
     Antibodies for ADAM33
     ELISAs for ADAM33
     CLIAs for ADAM33



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM33
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM33
     SwitchGear 3'UTR luciferase reporter plasmids for ADAM33
     SwitchGear Promoter luciferase reporter plasmids for ADAM33
     ThermoFisher Antibodies for ADAM33
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM33
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM33
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM33
     LSBio Antibodies in human, mouse, rat for ADAM33
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAM33 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4