Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAM32 Gene

Aliases for ADAM32 Gene

  • ADAM Metallopeptidase Domain 32 2 3 5
  • A Disintegrin And Metalloproteinase Domain 32 2
  • ADAM 32 4

External Ids for ADAM32 Gene

Previous GeneCards Identifiers for ADAM32 Gene

  • GC08P039179
  • GC08P038706
  • GC08P038982
  • GC08P038965
  • GC08P037498

Summaries for ADAM32 Gene

Entrez Gene Summary for ADAM32 Gene

  • This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

GeneCards Summary for ADAM32 Gene

ADAM32 (ADAM Metallopeptidase Domain 32) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot for ADAM32 Gene

  • May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM32 Gene

Genomics for ADAM32 Gene

Regulatory Elements for ADAM32 Gene

Enhancers for ADAM32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G038995 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.3 -106.2 -106194 10.8 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ADAM32 HTRA4 ENSG00000253645 PLEKHA2 ENSG00000272128 ADAM9 GC08M039018 ENSG00000207199
GH08G039035 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.5 -69.2 -69249 5.3 FOXA2 ATF1 ARNT SIN3A YY1 GATA2 FOS DEK ZNF202 JUNB ADAM32 ADAM9 TM2D2 ENSG00000272128 HTRA4 TACC1 PLEKHA2 GC08M039018 ENSG00000207199
GH08G039032 1.4 Ensembl ENCODE dbSUPER 32 -73.9 -73892 2.2 FOXA2 ARID4B KLF17 SIN3A ZNF48 GTF3C2 EGR1 KLF7 EGR2 SP3 ADAM32 ADAM9 GC08M039018 ENSG00000207199
GH08G039041 1.4 Ensembl ENCODE dbSUPER 31.2 -64.7 -64734 1.8 HDGF SIN3A RAD21 ZNF335 ZNF121 SCRT2 ZNF143 FOS RELB CREM ADAM32 ENSG00000207199 ADAM9 TM2D2 ENSG00000272128 GC08M039018
GH08G038955 1.4 Ensembl ENCODE dbSUPER 18.5 -150.0 -150016 4.0 HDGF TBP PKNOX1 TBL1XR1 BMI1 CBX5 SCRT2 ZNF143 RCOR1 RELB ADAM32 PLEKHA2 TM2D2 ENSG00000253645
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM32 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223787 710 600 CTCF ZNF687 RFX1 EED MAX ZBTB33 RAD21 MYC

Genomic Location for ADAM32 Gene

Chromosome:
8
Start:
39,106,990 bp from pter
End:
39,284,917 bp from pter
Size:
177,928 bases
Orientation:
Plus strand

Genomic View for ADAM32 Gene

Genes around ADAM32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM32 Gene

Proteins for ADAM32 Gene

  • Protein details for ADAM32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC27-ADA32_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 32
    Protein Accession:
    Q8TC27
    Secondary Accessions:
    • Q8TC42

    Protein attributes for ADAM32 Gene

    Size:
    787 amino acids
    Molecular mass:
    87948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADAM32 Gene

Post-translational modifications for ADAM32 Gene

  • Glycosylation at Asn39, Asn125, Asn465, and Asn598
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADAM32 Gene

Domains & Families for ADAM32 Gene

Gene Families for ADAM32 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM32: view

No data available for UniProtKB/Swiss-Prot for ADAM32 Gene

Function for ADAM32 Gene

Molecular function for ADAM32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Gene Ontology (GO) - Molecular Function for ADAM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM32: view
genes like me logo Genes that share phenotypes with ADAM32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM32

CRISPR Products

miRNA for ADAM32 Gene

miRTarBase miRNAs that target ADAM32

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM32 Gene

Localization for ADAM32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM32 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM32: view

Pathways & Interactions for ADAM32 Gene

SuperPathways for ADAM32 Gene

No Data Available

Interacting Proteins for ADAM32 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369238%0d%0a9606.ENSP00000387356%0d%0a9606.ENSP00000381425%0d%0a9606.ENSP00000222644%0d%0a9606.ENSP00000367408%0d%0a9606.ENSP00000358547%0d%0a
Selected Interacting proteins: ENSP00000369238 Q8TC27-ADA32_HUMAN for ADAM32 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADAM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM32: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM32 Gene

Drugs & Compounds for ADAM32 Gene

No Compound Related Data Available

Transcripts for ADAM32 Gene

Unigene Clusters for ADAM32 Gene

ADAM metallopeptidase domain 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM32 Gene

No ASD Table

Relevant External Links for ADAM32 Gene

GeneLoc Exon Structure for
ADAM32
ECgene alternative splicing isoforms for
ADAM32

Expression for ADAM32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM32 Gene

This gene is overexpressed in Testis (x24.5).

Protein differential expression in normal tissues from HIPED for ADAM32 Gene

This gene is overexpressed in Testis (61.0) and Ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM32 Gene



Protein tissue co-expression partners for ADAM32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM32 Gene:

ADAM32

SOURCE GeneReport for Unigene cluster for ADAM32 Gene:

Hs.521545

mRNA Expression by UniProt/SwissProt for ADAM32 Gene:

Q8TC27-ADA32_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with ADAM32: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM32 Gene

Orthologs for ADAM32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAM32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM32 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM32 34 35
  • 79.48 (n)
cow
(Bos Taurus)
Mammalia ADAM32 34 35
  • 77.82 (n)
mouse
(Mus musculus)
Mammalia Adam32 34 16 35
  • 69.95 (n)
rat
(Rattus norvegicus)
Mammalia Adam32 34
  • 68.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM32 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM32 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857794 34
  • 48.16 (n)
Species where no ortholog for ADAM32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM32 Gene

ENSEMBL:
Gene Tree for ADAM32 (if available)
TreeFam:
Gene Tree for ADAM32 (if available)

Paralogs for ADAM32 Gene

Paralogs for ADAM32 Gene

Pseudogenes.org Pseudogenes for ADAM32 Gene

genes like me logo Genes that share paralogs with ADAM32: view

Variants for ADAM32 Gene

Sequence variations from dbSNP and Humsavar for ADAM32 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000004010 -- 39,195,184(+) GAGCC(C/T)ACCAG intron-variant
rs1000035586 -- 39,279,528(+) CCACT(C/T)GCCTC intron-variant
rs1000050758 -- 39,238,754(+) GAAAT(A/G)AAAGA intron-variant
rs1000053634 -- 39,187,587(+) AAATA(C/T)GTCAG intron-variant
rs1000062824 -- 39,244,980(+) GCAAA(C/T)GCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM32 Gene

Variant ID Type Subtype PubMed ID
esv1142468 CNV deletion 17803354
esv2158875 CNV deletion 18987734
esv2664833 CNV deletion 23128226
esv2736898 CNV deletion 23290073
esv2736899 CNV deletion 23290073
esv3616939 CNV loss 21293372
esv3616940 CNV gain 21293372
esv3616941 CNV loss 21293372
esv3616942 CNV loss 21293372
esv3616943 CNV gain 21293372
esv3616944 CNV loss 21293372
nsv1075132 CNV deletion 25765185
nsv1132140 CNV deletion 24896259
nsv397485 CNV deletion 16902084
nsv428198 CNV gain 18775914
nsv507460 OTHER sequence alteration 20534489
nsv6162 CNV insertion 18451855
nsv824603 CNV gain 20364138
nsv958507 CNV deletion 24416366
nsv981929 CNV duplication 23825009

Variation tolerance for ADAM32 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM32 Gene

Disorders for ADAM32 Gene

Relevant External Links for ADAM32

Genetic Association Database (GAD)
ADAM32
Human Genome Epidemiology (HuGE) Navigator
ADAM32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM32

No disorders were found for ADAM32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM32 Gene

Publications for ADAM32 Gene

  1. Identification and characterization of ADAM32 with testis-predominant gene expression. (PMID: 12568724) Choi I. … Cho C. (Gene 2003) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ADAM32 Gene

Sources for ADAM32 Gene

Content
Loading form....