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Aliases for ADAM32 Gene

Aliases for ADAM32 Gene

  • ADAM Metallopeptidase Domain 32 2 3 5
  • A Disintegrin And Metalloproteinase Domain 32 2
  • ADAM 32 4

External Ids for ADAM32 Gene

Previous GeneCards Identifiers for ADAM32 Gene

  • GC08P039179
  • GC08P038706
  • GC08P038982
  • GC08P038965
  • GC08P037498

Summaries for ADAM32 Gene

Entrez Gene Summary for ADAM32 Gene

  • This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

GeneCards Summary for ADAM32 Gene

ADAM32 (ADAM Metallopeptidase Domain 32) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot for ADAM32 Gene

  • May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM32 Gene

Genomics for ADAM32 Gene

Regulatory Elements for ADAM32 Gene

Promoters for ADAM32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM32 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM32 Gene

Chromosome:
8
Start:
39,106,990 bp from pter
End:
39,284,917 bp from pter
Size:
177,928 bases
Orientation:
Plus strand

Genomic View for ADAM32 Gene

Genes around ADAM32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM32 Gene

Proteins for ADAM32 Gene

  • Protein details for ADAM32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC27-ADA32_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 32
    Protein Accession:
    Q8TC27
    Secondary Accessions:
    • Q8TC42

    Protein attributes for ADAM32 Gene

    Size:
    787 amino acids
    Molecular mass:
    87948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADAM32 Gene

Proteomics data for ADAM32 Gene at MOPED

Post-translational modifications for ADAM32 Gene

  • Glycosylation at Asn 39, Asn 125, Asn 465, and Asn 598
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADAM32 Gene

Domains & Families for ADAM32 Gene

Gene Families for ADAM32 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TC27

UniProtKB/Swiss-Prot:

ADA32_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM32: view

Function for ADAM32 Gene

Molecular function for ADAM32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Gene Ontology (GO) - Molecular Function for ADAM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM32: view
genes like me logo Genes that share phenotypes with ADAM32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM32

miRNA for ADAM32 Gene

miRTarBase miRNAs that target ADAM32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM32 Gene

Localization for ADAM32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM32 Gene COMPARTMENTS Subcellular localization image for ADAM32 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADAM32 Gene

Pathways & Interactions for ADAM32 Gene

SuperPathways for ADAM32 Gene

No Data Available

Interacting Proteins for ADAM32 Gene

Gene Ontology (GO) - Biological Process for ADAM32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADAM32 Gene

Drugs & Compounds for ADAM32 Gene

No Compound Related Data Available

Transcripts for ADAM32 Gene

Unigene Clusters for ADAM32 Gene

ADAM metallopeptidase domain 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM32 Gene

No ASD Table

Relevant External Links for ADAM32 Gene

GeneLoc Exon Structure for
ADAM32
ECgene alternative splicing isoforms for
ADAM32

Expression for ADAM32 Gene

mRNA expression in normal human tissues for ADAM32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM32 Gene

This gene is overexpressed in Testis (x24.5).

Protein differential expression in normal tissues from HIPED for ADAM32 Gene

This gene is overexpressed in Testis (61.0) and Ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM32 Gene



SOURCE GeneReport for Unigene cluster for ADAM32 Gene Hs.521545

mRNA Expression by UniProt/SwissProt for ADAM32 Gene

Q8TC27-ADA32_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with ADAM32: view

Protein tissue co-expression partners for ADAM32 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADAM32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAM32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM32 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM32 36
  • 63 (a)
OneToOne
ADAM32 35
  • 77.82 (n)
  • 65.18 (a)
dog
(Canis familiaris)
Mammalia ADAM32 35
  • 79.48 (n)
  • 67.88 (a)
ADAM32 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam32 36
  • 60 (a)
OneToOne
Adam32 16
Adam32 35
  • 69.95 (n)
  • 60.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM32 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM32 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam32 35
  • 68.84 (n)
  • 60.42 (a)
chicken
(Gallus gallus)
Aves LOC100857794 35
  • 48.16 (n)
  • 40.89 (a)
Species with no ortholog for ADAM32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM32 Gene

ENSEMBL:
Gene Tree for ADAM32 (if available)
TreeFam:
Gene Tree for ADAM32 (if available)

Paralogs for ADAM32 Gene

Paralogs for ADAM32 Gene

Pseudogenes.org Pseudogenes for ADAM32 Gene

genes like me logo Genes that share paralogs with ADAM32: view

Variants for ADAM32 Gene

Sequence variations from dbSNP and Humsavar for ADAM32 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7845771 - 39,223,113(+) TGGAA(C/G)CTCAC reference, missense
rs17856744 - 39,149,807(+) CTATC(A/G)AGGAA reference, missense
rs17852343 - 39,151,501(+) ACAGA(A/G)GCCTG reference, missense
rs9643859 - 39,186,972(+) TCAGT(C/G)TGGGA intron-variant, reference, missense
rs13277386 - 39,254,485(+) TCCAA(A/C/T)GGATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAM32 Gene

Variant ID Type Subtype PubMed ID
nsv6162 CNV Insertion 18451855
esv2736898 CNV Deletion 23290073
esv2736899 CNV Deletion 23290073
esv2158875 CNV Deletion 18987734
esv1142468 CNV Deletion 17803354
nsv397485 CNV Loss 16902084
nsv507460 CNV Insertion 20534489
nsv428198 CNV Gain 18775914
nsv824603 CNV Gain 20364138
esv2664833 CNV Deletion 23128226

Variation tolerance for ADAM32 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM32 Gene

HapMap Linkage Disequilibrium report
ADAM32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM32 Gene

Disorders for ADAM32 Gene

Relevant External Links for ADAM32

Genetic Association Database (GAD)
ADAM32
Human Genome Epidemiology (HuGE) Navigator
ADAM32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM32

No disorders were found for ADAM32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM32 Gene

Publications for ADAM32 Gene

  1. Identification and characterization of ADAM32 with testis-predominant gene expression. (PMID: 12568724) Choi I. … Cho C. (Gene 2003) 2 3 4 23 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ADAM32 Gene

Sources for ADAM32 Gene

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