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Aliases for ADAM30 Gene

Aliases for ADAM30 Gene

  • ADAM Metallopeptidase Domain 30 2 3
  • A Disintegrin And Metalloproteinase Domain 30 2 3
  • Disintegrin And Metalloproteinase Domain-Containing Protein 30 3
  • EC 3.4.24.- 4
  • ADAM 30 4
  • Svph4 3

External Ids for ADAM30 Gene

Previous GeneCards Identifiers for ADAM30 Gene

  • GC01M120882
  • GC01M119274
  • GC01M119583
  • GC01M119782
  • GC01M120148
  • GC01M120237
  • GC01M120436
  • GC01M118294

Summaries for ADAM30 Gene

Entrez Gene Summary for ADAM30 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM30 Gene

ADAM30 (ADAM Metallopeptidase Domain 30) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM30 Gene

  • May be involved in spermatogenesis and fertilization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM30 Gene

Genomics for ADAM30 Gene

Regulatory Elements for ADAM30 Gene

Genomic Location for ADAM30 Gene

Start:
119,893,533 bp from pter
End:
119,896,524 bp from pter
Size:
2,992 bases
Orientation:
Minus strand

Genomic View for ADAM30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM30 Gene

Proteins for ADAM30 Gene

  • Protein details for ADAM30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKF2-ADA30_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 30
    Protein Accession:
    Q9UKF2
    Secondary Accessions:
    • A8K8W8
    • Q5T3X6
    • Q9UKF1

    Protein attributes for ADAM30 Gene

    Size:
    790 amino acids
    Molecular mass:
    88940 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM30 Gene

Proteomics data for ADAM30 Gene at MOPED

Post-translational modifications for ADAM30 Gene

  • Glycosylation at Asn222, Asn372, Asn438, Asn473, and Asn625
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM30 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAM30 Gene

Domains for ADAM30 Gene

Gene Families for ADAM30 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM30 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKF2

UniProtKB/Swiss-Prot:

ADA30_HUMAN :
  • Q9UKF2
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM30: view

Function for ADAM30 Gene

Molecular function for ADAM30 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease domain 30,membrane anchored cell surface adhesion protein,testis specific with alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: May be involved in spermatogenesis and fertilization

Enzyme Numbers (IUBMB) for ADAM30 Gene

Gene Ontology (GO) - Molecular Function for ADAM30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008237 metallopeptidase activity TAS 10512762
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM30: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM30

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM30 Gene

Localization for ADAM30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM30 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM30 Gene COMPARTMENTS Subcellular localization image for ADAM30 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM30: view

Pathways for ADAM30 Gene

SuperPathways for ADAM30 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ADAM30: view

Pathways by source for ADAM30 Gene

3 Reactome pathways for ADAM30 Gene

Interacting Proteins for ADAM30 Gene

Gene Ontology (GO) - Biological Process for ADAM30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with ADAM30: view

Transcripts for ADAM30 Gene

mRNA/cDNA for ADAM30 Gene

(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM30 Gene

ADAM metallopeptidase domain 30:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM30

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM30 Gene

No ASD Table

Relevant External Links for ADAM30 Gene

GeneLoc Exon Structure for
ADAM30
ECgene alternative splicing isoforms for
ADAM30

Expression for ADAM30 Gene

mRNA expression in normal human tissues for ADAM30 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM30 Gene

This gene is overexpressed in Testis (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM30 Gene

SOURCE GeneReport for Unigene cluster for ADAM30 Gene Hs.283011

mRNA Expression by UniProt/SwissProt for ADAM30 Gene

Q9UKF2-ADA30_HUMAN
Tissue specificity: Expressed specifically in testis
genes like me logo Genes that share expressions with ADAM30: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM30 Gene

Orthologs for ADAM30 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM30 35
  • 99.4 (n)
  • 99.62 (a)
ADAM30 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
LOC531521 35
  • 76.9 (n)
  • 67.61 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
LOC608067 35
  • 74.76 (n)
  • 62.55 (a)
mouse
(Mus musculus)
Mammalia Adam30 35
  • 68.53 (n)
  • 58.58 (a)
Adam30 16
Adam30 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM30 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adam30 35
  • 67.78 (n)
  • 59.27 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Neu3 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ADAM30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM30 Gene

ENSEMBL:
Gene Tree for ADAM30 (if available)
TreeFam:
Gene Tree for ADAM30 (if available)

Paralogs for ADAM30 Gene

Selected SIMAP similar genes for ADAM30 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAM30: view

Variants for ADAM30 Gene

Sequence variations from dbSNP and Humsavar for ADAM30 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2027447 -- 119,897,406(+) AAAGC(C/T)CTTGT upstream-variant-2KB
rs2641315 -- 119,898,203(+) TCACA(C/G)GTCAT upstream-variant-2KB
rs2641348 - 119,895,261(-) TAGGC(A/C/G/T)TAATT missense, reference
rs2793823 -- 119,895,095(+) CCACA(A/G)TCACA reference, synonymous-codon
rs6428846 -- 119,897,026(+) TTTGC(C/T)TGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADAM30 Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV Gain 19592680
nsv831215 CNV Gain 17160897
dgv93e1 CNV Complex 17122850
nsv428201 CNV Gain 18775914
dgv94e1 CNV Complex 17122850
nsv831226 CNV Gain+Loss 17160897
nsv436325 CNV Deletion 17901297

Relevant External Links for ADAM30 Gene

HapMap Linkage Disequilibrium report
ADAM30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM30 Gene

Disorders for ADAM30 Gene

Relevant External Links for ADAM30

Genetic Association Database (GAD)
ADAM30
Human Genome Epidemiology (HuGE) Navigator
ADAM30
genes like me logo Genes that share disorders with ADAM30: view

No data available for UniProtKB/Swiss-Prot for ADAM30 Gene

Publications for ADAM30 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PMID: 18372903) Zeggini E. … Altshuler D. (Nat. Genet. 2008) 3 48
  4. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. (PMID: 18591388) Lango H. … Weedon M.N. (Diabetes 2008) 3 48
  5. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. (PMID: 19862325) Hu C. … Jia W. (PLoS ONE 2009) 3 48

Products for ADAM30 Gene

Sources for ADAM30 Gene

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