Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADAM30 Gene

protein-coding   GIFtS: 50
GCID: GC01M120436

ADAM Metallopeptidase Domain 30

(Previous name: a disintegrin and metalloproteinase domain 30)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADAM Metallopeptidase Domain 301 2
A Disintegrin And Metalloproteinase Domain 301 2
Disintegrin And Metalloproteinase Domain-Containing Protein 302
svph42
EC 3.4.24.-3
ADAM 303

External Ids:    HGNC: 2081   Entrez Gene: 110852   Ensembl: ENSG000001342497   OMIM: 6047795   UniProtKB: Q9UKF23   

Export aliases for ADAM30 gene to outside databases

Previous GC identifers: GC01M120882 GC01M119274 GC01M119583 GC01M119782 GC01M120148 GC01M120237 GC01M118294


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADAM30 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in
isoforms with varying numbers of C-terminal repeats. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM30 Gene:
ADAM30 (ADAM metallopeptidase domain 30) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2
Function: May be involved in spermatogenesis and fertilization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM30 gene promoter:
         AML1a   Pax-2   Pax-2a   HNF-4alpha1   C/EBPalpha   Pax-3   HOXA5   COMP1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM30 promoter sequence
   Search Chromatin IP Primers for ADAM30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p12

ADAM30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM30 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M120436:  view genomic region     (about GC identifiers)

Start:
120,436,156 bp from pter      End:
120,439,147 bp from pter
Size:
2,992 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 30 precursor  
Size: 790 amino acids; 88940 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: A8K8W8 Q5T3X6 Q9UKF1
Alternative splicing: 2 isoforms:  Q9UKF2-1   Q9UKF2-2   

Explore the universe of human proteins at neXtProt for ADAM30: NX_Q9UKF2

Explore proteomics data for ADAM30 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn222, Asn372, Asn438, Asn473, Asn625

  • See ADAM30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068566.2  
    ENSEMBL proteins: 
     ENSP00000358407  
    Reactome Protein details: Q9UKF2

    ADAM30 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAM30
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAM30
    GenScript Custom Purified and Recombinant Proteins Services for ADAM30
    Novus Biologicals ADAM30 Protein
    Novus Biologicals ADAM30 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM30

     
    Search eBioscience for Proteins for ADAM30 

     
    antibodies-online proteins for ADAM30 (3 products) 

     
    antibodies-online peptides for ADAM30

    ADAM30 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADAM30
    Novus Biologicals ADAM30 Antibodies
    Abcam antibodies for ADAM30 (Q8TBZ7, Q9UKF2)
    Cloud-Clone Corp. Antibodies for ADAM30
    Search ThermoFisher Antibodies for ADAM30
    antibodies-online antibodies for ADAM30 (11 products) 

    ADAM30 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAM30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAM30
    Cloud-Clone Corp. CLIAs for ADAM30
    Search eBioscience for ELISAs for ADAM30 
    antibodies-online kits for ADAM30 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM30
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry Q9UKF2

    ProtoNet protein and cluster: Q9UKF2

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Find genes that share domains with ADAM30           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA30_HUMAN, Q9UKF2
    Function: May be involved in spermatogenesis and fertilization

         Genatlas biochemistry entry for ADAM30:
    a disintegrin and metalloprotease domain 30,membrane anchored cell surface adhesion protein,testis specific with
    alternatively spliced isoforms

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity TAS10512762
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAM30           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Adam30 (no phenotypes)

    Find genes that share phenotypes with ADAM30           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adam30tm1Lex for ADAM30

       genOway: Develop your customized and physiologically relevant rodent model for ADAM30

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ADAM30 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ADAM30:
    hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmidADAM30 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAM30
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAM30

    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM30 (see all 7)
    OriGene ORF clones in mouse, rat for ADAM30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM30 (NM_021794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM30

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAM30
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM30 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ADA30_HUMAN, Q9UKF2: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ADAM30           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADAM30 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00


    Find genes that share SuperPaths with ADAM30           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAM30
        Interaction With The Zona Pellucida


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM30
    Interactions:

        Search GeneGlobe Interaction Network for ADAM30

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--
    GO:0032504multicellular organism reproduction TAS--

    Find genes that share ontologies with ADAM30           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM30 (ADA30)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADAM30 gene: 
    NM_021794.3  

    Unigene Cluster for ADAM30:

    ADAM metallopeptidase domain 30
    Hs.283011  [show with all ESTs]
    Unigene Representative Sequence: NM_021794
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369400(uc001eij.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADAM30 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ADAM30:
    hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmidADAM30 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADAM30
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM30
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM30 (see all 7)
    OriGene ORF clones in mouse, rat for ADAM30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM30 (NM_021794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM30
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADAM30
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM30
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM30
      QuantiFast Probe-based Assays in human, mouse, rat ADAM30

    Additional mRNA sequence: 

    AF171932.1 AF171933.1 AK292483.1 AY358734.1 BC028372.2 

    2 DOTS entries:

    DT.455015  DT.121448078 

    12 AceView cDNA sequences:

    NM_021794 AY358734 AF171932 AF171933 AA883775 BX095813 BG717824 BC028372 
    BG718870 BG772238 AI214466 CD300203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADAM30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATACCTG
    ADAM30 Expression
    About this image

    ADAM30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283011

    UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2
    Tissue specificity: Expressed specifically in testis

        Custom PCR Arrays for ADAM30
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADAM30
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM30
    QuantiTect SYBR Green Assays in human, mouse, rat ADAM30
    QuantiFast Probe-based Assays in human, mouse, rat ADAM30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ADAM30 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam301 , 5 a disintegrin and metallopeptidase domain 301, 5 68.53(n)1
    58.58(a)1
      3 (42.63 cM)5
    710781  NM_027665.11  NP_081941.11 
     981608125 
    chicken
    (Gallus gallus)
    Aves --
    Gallus gallus disintegrin and metalloproteinase do...
    35(a)
    1 → many
    5(26725432-26727609)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    38(a)
    38(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    GL343753.1(81294-83348)
    GL343318.1(1411700-1413799)
    fruit fly
    (Drosophila melanogaster)
    Insecta Neu36
    Neu3
    14(a)
    1 → many
    3R(10491559-10523057)
    worm
    (Caenorhabditis elegans)
    Secernentea adm-26
    Protein ADM-2 (adm-2) mRNA, complete cds
    21(a)
    1 → many
    X(13687973-13695791) WBGene00000074


    ENSEMBL Gene Tree for ADAM30 (if available)
    TreeFam Gene Tree for ADAM30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADAM30 gene
    ADAM72  ADAM192  ADAM122  ADAM332  ADAM282  ADAM292  ADAM202  ADAM212  
    ADAM92  ADAM152  ADAM82  
    11 SIMAP similar genes for ADAM30 using alignment to 2 protein entries:     ADA30_HUMAN (see all proteins):
    ADAM21    ADAM20    ADAM9    ADAM29    ADAM18    ADAM19
    ADAM2    ADAM7    ADAM32    ADAM12    ADAM33

    Find genes that share paralogs with ADAM30           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADAM30 (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798739541,2
    F--120435725(+) CTGACA/GCAAAT 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs120755361,2
    C,F,H--120435771(+) GGATAC/TTGACT 1 -- ds500118Minor allele frequency- T:0.07NS EA NA WA 2340
    rs1497459771,2
    --120435861(+) CGGGGG/TTCCTT 1 -- ds50010--------
    rs1467443541,2
    C--120435874(+) AAGGCA/GTTCCT 1 -- ds50010--------
    rs1886000711,2
    --120435896(+) TGTGCG/TACTTA 1 -- ds50010--------
    rs1403640461,2
    --120436034(+) CTGGCA/GTCATC 1 -- ds50010--------
    rs1932656151,2
    --120436059(+) CTGTGA/GTGCAA 1 -- ds50010--------
    rs120757071,2
    C,H--120436164(+) GTTGTC/TGGCAT 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 414
    rs1454492531,2
    C--120436170(+) GGCATC/TTATTG 1 -- ut310--------
    rs1841728361,2
    --120436214(+) GATCAA/GGTTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM30 (120436156 - 120439147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADAM30:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436325CNV Deletion17901297
    nsv831215CNV Gain17160897
    nsv524681CNV Gain19592680
    nsv428201CNV Gain18775914
    nsv831226CNV Gain+Loss17160897
    dgv94e1CNV Complex17122850
    dgv93e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM30
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604779    OMIM disorders: --


    Find genes that share disorders with ADAM30           About GenesLikeMe

    Genetic Association Database (GAD): ADAM30
    Human Genome Epidemiology (HuGE) Navigator: ADAM30 (2 documents)

    Export disorders for ADAM30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADAM30 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ADAM30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. (PubMed id 19862325)1, 4 Hu C....Jia W. (PLoS ONE 2009)
    2. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. (PubMed id 18591388)1, 4 Lango H....Weedon M.N. (Diabetes 2008)
    3. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1, 4 Zeggini E....Altshuler D. (Nat. Genet. 2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. (PubMed id 10512762)1, 2 Cerretti D.P.... Nelson N. (Biochem. Biophys. Res. Commun. 1999)
    7. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11085 HGNC: 208 AceView: ADAM30 Ensembl:ENSG00000134249 euGenes: HUgn11085
    ECgene: ADAM30 H-InvDB: ADAM30

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADAM30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAM30 gene:
    Search GeneIP for patents involving ADAM30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADAM30  
     OriGene qPCR primer pairs and template standards for ADAM30   OriGene Protein Over-expression Lysate for ADAM30  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAM30  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAM30   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAM30   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAM30   OriGene Custom Protein Services for ADAM30  

     
     
     Block miRNA regulation of human, mouse, rat ADAM30 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAM30
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM30 Predesigned siRNA for gene silencing in human, mouse, rat ADAM30
     QuantiFast Probe-based Assays in human, mouse, rat ADAM30 QuantiTect SYBR Green Assays in human, mouse, rat ADAM30
     Custom PCR Arrays for ADAM30 Search Chromatin IP Primers for ADAM30
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM30  Search GeneGlobe Interaction Network for ADAM30
     Regulatory tfbs in ADAM30 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADAM30 GenScript cDNA clones with any tag delivered in your preferred vector for ADAM30
     GenScript Custom Assay Services for ADAM30 GenScript Custom overexpressing Cell Line Services for ADAM30
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ADAM30 (ADA30)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADAM30 antibodies
     ADAM30 proteins
     ADAM30 lysates
     Antibodies for ADAM30
     See all of Abcam's Antibodies, Kits and Proteins for ADAM30
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ADAM30
     Antibodies for ADAM30
     ELISAs for ADAM30
     CLIAs for ADAM30



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30
     SwitchGear 3'UTR luciferase reporter plasmids for ADAM30
     SwitchGear Promoter luciferase reporter plasmids for ADAM30
     Search ThermoFisher Antibodies for ADAM30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM30
     Browse compounds at ApexBio
     Search Addgene for plasmids for ADAM30
      Search eBioscience for proteins for ADAM30
      Search eBioscience for elisas for ADAM30
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ADAM30
     antibodies-online antibodies for ADAM30 (11 products)
     antibodies-online kits for ADAM30 (2 products)
     antibodies-online peptides for ADAM30
     antibodies-online proteins for ADAM30 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAM30 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4