ADAM30 Gene
protein-coding GIFtS: 44
GCID: GC01M120436
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ADAM metallopeptidase domain 30(Previous name: a disintegrin and metalloproteinase domain 30 )
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Aliases
for ADAM30 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 301 2 | | A Disintegrin And Metalloproteinase Domain 301 2 | | Svph41 | | Disintegrin And Metalloproteinase Domain-Containing Protein 302 | | EC 3.4.24.-3 | | ADAM 303 |
Export aliases for ADAM30 gene to outside databasesPrevious GC identifers: GC01M120882 GC01M119274 GC01M119583 GC01M119782 GC01M120148 GC01M120237 GC01M118294 |
Summaries
for ADAM30 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM30:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety ofbiological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varyingnumbers of C-terminal repeats. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2Function: May be involved in spermatogenesis and fertilization
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Genomic Views
for ADAM30 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM30 gene promoter:
AML1a Pax-2 Pax-2a HNF-4alpha1 C/EBPalpha Pax-3 HOXA5 COMP1 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM30
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM30 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p12 Ensembl cytogenetic band: 1p12 HGNC cytogenetic band: 1p12ADAM30 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M120436: view genomic region
(about GC identifiers)
Start:
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120,436,156 bp from pter |
End:
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120,439,118 bp from pter |
Size:
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2,963 bases |
Orientation:
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minus strand |
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Proteins
for ADAM30 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 30 precursor Size: 790 amino acids; 88940 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A8K8W8 Q5T3X6 Q9UKF1Alternative splicing: 2 isoforms: Q9UKF2-1 Q9UKF2-2 Explore the universe of human proteins at neXtProt for ADAM30: NX_Q9UKF2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKF2
ADAM30 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068566.2
ENSEMBL proteins: ENSP00000358407
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ADAM30 for ontologies About GeneDecksing
ADAM30 Antibody Products:
Assay Products for ADAM30: |
Protein
Domains /
Families
for ADAM30 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM30 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9UKF2ProtoNet protein and cluster: Q9UKF2 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain |
Function
for ADAM30 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2Function: May be involved in spermatogenesis and fertilization Genatlas biochemistry entry for ADAM30:a disintegrin and metalloprotease domain 30,membrane anchored cell surface adhesion protein,testis specific withalternatively spliced isoforms
Enzyme Number (IUBMB): EC 3.4.24.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM30
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ADAM30 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Adam30tm1Lex for ADAM30
1 MGI phenotypic allele  for Adam30 (no phenotypes)
ADAM30 for phenotypes About GeneDecksing
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Pathways & Interactions
for ADAM30 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM30
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
ADAM30 for ontologies About GeneDecksing
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Drugs & Compounds
for ADAM30 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAM30
Search CenterWatch for drugs/clinical trials and news about ADAM30 / ADA30
|
Transcripts
for ADAM30 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAM30 gene: NM_021794.3 Unigene Cluster for ADAM30: ADAM metallopeptidase domain 30 Hs.283011 [show with all ESTs]Unigene Representative Sequence: NM_0217941 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369400(uc001eij.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM30 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM30
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAM30 (NM_021794) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM30 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM30 |
Additional cDNA sequence: AF171932.1 AF171933.1 AK292483.1 AY358734.1 BC028372.2 2 DOTS entries: DT.455015 DT.121448078 12 AceView cDNA sequences: NM_021794 AA883775 AF171932 AY358734 AF171933 BX095813 BG717824 BG772238 BG718870 BC028372 AI214466 CD300203
GeneLoc Exon Structure
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Expression
for ADAM30 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM30 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAATACCTG
About this image
See ADAM30 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM30
SOURCE GeneReport for Unigene cluster: Hs.283011
UniProtKB/Swiss-Prot: ADA30_HUMAN, Q9UKF2Tissue specificity: Expressed specifically in testis
SABiosciences Custom PCR Arrays for ADAM30
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM30
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM30 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM30 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM30 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30 |
Orthologs
for ADAM30 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ADAM30 gene from 2/15 species (see all 15) About this table
ENSEMBL Gene Tree for ADAM30 (if available)
TreeFam Gene Tree for ADAM30 (if available) |
Paralogs
for ADAM30 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAM30 gene
- ADAM72 ADAM192 ADAM122 ADAM232 ADAM332 ADAM112 ADAM222 ADAM282
- ADAM292 ADAM202 ADAM92 ADAM212 ADAM152 ADAM82
12 SIMAP similar genes for ADAM30 using alignment to 2 protein entries: ADA30_HUMAN (see all proteins):ADAM21 ADAM20 ADAM9 ADAM29 ADAM18 ADAM19
ADAM2 ADAM7 ADAM32 ADAM12 ADAM33 ADAM8
ADAM30 for paralogs About GeneDecksing
|
Genomic Variants
for ADAM30 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAM30 (120436156 - 120439118 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ADAM30
3 CNVs: 22949 4245 3309 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM30 |
|
Disorders
/ Diseases
for ADAM30 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ADAM30 for disorders About MalaCards
ADAM30 for disorders About GeneDecksing
OMIM gene information: 604779
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ADAM30 (2 documents)
Export disorders for ADAM30 gene to outside databases
|
Publications
for ADAM30 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM30 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM30) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. (PubMed id 10512762)1, 2 Cerretti D.P.... Nelson N. (1999)
- PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populatio n. (PubMed id 19862325)1 Hu C....Jia W. (2009)
- Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. (PubMed id 18591388)1 Lango H....Weedon M.N. (2008)
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1 Zeggini E....Altshuler D. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ADAM30 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ADAM30 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM30 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM30 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAM30 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ADAM30 gene:
Search GeneIP for patents involving ADAM30
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM30 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ADAM30 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM30 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM30 |
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