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Aliases for ADAM29 Gene

Aliases for ADAM29 Gene

  • ADAM Metallopeptidase Domain 29 2 3 5
  • Cancer/Testis Antigen 73 2 3 4
  • A Disintegrin And Metalloproteinase Domain 29 2 3
  • CT73 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 29 3
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Metallaproteinase-Disintegrin (ADAM29) 3
  • EC 3.4.24.58 61
  • EC 3.4.24 61
  • ADAM 29 4
  • Svph1 3

External Ids for ADAM29 Gene

Previous GeneCards Identifiers for ADAM29 Gene

  • GC04P176797
  • GC04P176390
  • GC04P176535
  • GC04P176214
  • GC04P176076
  • GC04P175839
  • GC04P171588
  • GC04P175751

Summaries for ADAM29 Gene

Entrez Gene Summary for ADAM29 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM29 Gene

ADAM29 (ADAM Metallopeptidase Domain 29) is a Protein Coding gene. Among its related pathways are Metabolism. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM20.

UniProtKB/Swiss-Prot for ADAM29 Gene

  • May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM29 Gene

Genomics for ADAM29 Gene

Regulatory Elements for ADAM29 Gene

Enhancers for ADAM29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F175428 0.3 FANTOM5 4.9 +598.6 598626 0.4 ADAM29 GC04M175445 ENSG00000248551
GH04F174828 0.5 ENCODE 0.8 -0.2 -227 1.1 CTCF PKNOX1 TEAD4 SIN3A E2F1 ZNF316 POLR2A NFYB ZNF143 ZSCAN29 ADAM29 GLRA3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAM29 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM29 Gene

Chromosome:
4
Start:
174,829,668 bp from pter
End:
174,978,180 bp from pter
Size:
148,513 bases
Orientation:
Plus strand

Genomic View for ADAM29 Gene

Genes around ADAM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM29 Gene

Proteins for ADAM29 Gene

  • Protein details for ADAM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKF5-ADA29_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 29
    Protein Accession:
    Q9UKF5
    Secondary Accessions:
    • Q4W5F3
    • Q9UHP1
    • Q9UKF3
    • Q9UKF4

    Protein attributes for ADAM29 Gene

    Size:
    820 amino acids
    Molecular mass:
    92759 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM29 Gene

Selected DME Specific Peptides for ADAM29 Gene

Q9UKF5:
  • EEGEECDCG
  • GEECDCG
  • GGSVDSGP

Post-translational modifications for ADAM29 Gene

  • Glycosylation at Asn 217, Asn 320, Asn 368, Asn 428, Asn 469, Asn 538, Asn 545, Asn 558, and Asn 564
  • Modification sites at PhosphoSitePlus

Domains & Families for ADAM29 Gene

Gene Families for ADAM29 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKF5

UniProtKB/Swiss-Prot:

ADA29_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM29: view

Function for ADAM29 Gene

Molecular function for ADAM29 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 29,membrane anchored cell surface adhesion protein,testis specific with alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

Enzyme Numbers (IUBMB) for ADAM29 Gene

Gene Ontology (GO) - Molecular Function for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view
genes like me logo Genes that share phenotypes with ADAM29: view

Animal Model Products

miRNA for ADAM29 Gene

miRTarBase miRNAs that target ADAM29

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM29 Gene

Localization for ADAM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM29 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM29 Gene COMPARTMENTS Subcellular localization image for ADAM29 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10512762
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM29: view

Pathways & Interactions for ADAM29 Gene

SuperPathways for ADAM29 Gene

SuperPathway Contained pathways
1 Metabolism
genes like me logo Genes that share pathways with ADAM29: view

Pathways by source for ADAM29 Gene

1 KEGG pathway for ADAM29 Gene

Interacting Proteins for ADAM29 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352177%0d%0a9606.ENSP00000285928%0d%0a9606.ENSP00000246194%0d%0a
Selected Interacting proteins: Q9UKF5-ADA29_HUMAN ENSP00000352177 for ADAM29 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view

No data available for SIGNOR curated interactions for ADAM29 Gene

Transcripts for ADAM29 Gene

Unigene Clusters for ADAM29 Gene

ADAM metallopeptidase domain 29:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM29 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - -

Relevant External Links for ADAM29 Gene

GeneLoc Exon Structure for
ADAM29
ECgene alternative splicing isoforms for
ADAM29

Expression for ADAM29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM29 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM29 Gene

This gene is overexpressed in Testis (x47.6).

Protein differential expression in normal tissues from HIPED for ADAM29 Gene

This gene is overexpressed in Plasma (34.6) and Liver, secretome (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM29 Gene



Protein tissue co-expression partners for ADAM29 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM29 Gene:

ADAM29

SOURCE GeneReport for Unigene cluster for ADAM29 Gene:

Hs.126838

mRNA Expression by UniProt/SwissProt for ADAM29 Gene:

Q9UKF5-ADA29_HUMAN
Tissue specificity: Expressed specifically in testes.
genes like me logo Genes that share expression patterns with ADAM29: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM29 Gene

Orthologs for ADAM29 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM29 34 35
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia ADAM29 34
  • 76.59 (n)
-- 35
  • 47 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adam29 34 16 35
  • 70.71 (n)
dog
(Canis familiaris)
Mammalia ADAM29 34 35
  • 70.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 41 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Neu3 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-2 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ADAM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM29 Gene

ENSEMBL:
Gene Tree for ADAM29 (if available)
TreeFam:
Gene Tree for ADAM29 (if available)

Paralogs for ADAM29 Gene

(11) SIMAP similar genes for ADAM29 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADAM29 Gene

genes like me logo Genes that share paralogs with ADAM29: view

Variants for ADAM29 Gene

Sequence variations from dbSNP and Humsavar for ADAM29 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs140083180 A cutaneous metastatic melanoma sample 174,976,294(+) ACCTC(A/T)TTGTA reference, missense
rs150047888 A cutaneous metastatic melanoma sample 174,976,733(+) GAATG(A/G)TGTTG reference, missense
rs267600087 A cutaneous metastatic melanoma sample 174,975,856(+) ACCCA(A/G)AATCC reference, missense
rs267600089 A cutaneous metastatic melanoma sample 174,976,439(+) TAGAG(A/G)AATGT reference, missense
rs267600090 A cutaneous metastatic melanoma sample 174,976,558(+) ATGAG(A/G)ATACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAM29 Gene

Variant ID Type Subtype PubMed ID
esv3603238 CNV gain 21293372
esv3603241 CNV loss 21293372
nsv830156 CNV gain 17160897

Variation tolerance for ADAM29 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM29 Gene

Disorders for ADAM29 Gene

UniProtKB/Swiss-Prot

ADA29_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. {ECO:0000269 PubMed:21618342}.

Relevant External Links for ADAM29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM29

No disorders were found for ADAM29 Gene.

No data available for MalaCards and Genatlas for ADAM29 Gene

Publications for ADAM29 Gene

  1. Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4. (PMID: 10644455) Xu R. … Li C. (Genomics 1999) 2 3 4 22 64
  2. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X. … Samuels Y. (Hum. Mutat. 2011) 3 4 64
  3. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. (PMID: 15802535) Oppezzo P. … Davi F. (Blood 2005) 3 22 64
  4. Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. (PMID: 10512762) Cerretti D.P. … Nelson N. (Biochem. Biophys. Res. Commun. 1999) 3 4 64
  5. ADAM29 Expression in Human Breast Cancer and its Effects on Breast Cancer Cells In Vitro. (PMID: 26977022) Zhao M. … Song M. (Anticancer Res. 2016) 3 64

Products for ADAM29 Gene

Sources for ADAM29 Gene

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