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Aliases for ADAM29 Gene

Aliases for ADAM29 Gene

  • ADAM Metallopeptidase Domain 29 2 3
  • Cancer/Testis Antigen 73 2 3 4
  • A Disintegrin And Metalloproteinase Domain 29 2 3
  • CT73 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 29 3
  • Metallaproteinase-Disintegrin (ADAM29) 3
  • EC 3.4.24.58 63
  • EC 3.4.24 63
  • ADAM 29 4
  • Svph1 3

External Ids for ADAM29 Gene

Previous GeneCards Identifiers for ADAM29 Gene

  • GC04P176797
  • GC04P176390
  • GC04P176535
  • GC04P176214
  • GC04P176076
  • GC04P175839
  • GC04P171588
  • GC04P175751

Summaries for ADAM29 Gene

Entrez Gene Summary for ADAM29 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM29 Gene

ADAM29 (ADAM Metallopeptidase Domain 29) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM29 Gene

  • May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM29 Gene

Genomics for ADAM29 Gene

Regulatory Elements for ADAM29 Gene

Genomic Location for ADAM29 Gene

Start:
174,829,668 bp from pter
End:
174,978,180 bp from pter
Size:
148,513 bases
Orientation:
Plus strand

Genomic View for ADAM29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM29 Gene

Proteins for ADAM29 Gene

  • Protein details for ADAM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKF5-ADA29_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 29
    Protein Accession:
    Q9UKF5
    Secondary Accessions:
    • Q4W5F3
    • Q9UHP1
    • Q9UKF3
    • Q9UKF4

    Protein attributes for ADAM29 Gene

    Size:
    820 amino acids
    Molecular mass:
    92759 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM29 Gene

Proteomics data for ADAM29 Gene at MOPED

Selected DME Specific Peptides for ADAM29 Gene

Post-translational modifications for ADAM29 Gene

  • Glycosylation at Asn217, Asn320, Asn368, Asn428, Asn469, Asn538, Asn545, Asn558, and Asn564
  • Modification sites at PhosphoSitePlus

Domains for ADAM29 Gene

Gene Families for ADAM29 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9UKF5

UniProtKB/Swiss-Prot:

ADA29_HUMAN :
  • Q9UKF5
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM29: view

Function for ADAM29 Gene

Molecular function for ADAM29 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease domain 29,membrane anchored cell surface adhesion protein,testis specific with alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein

Enzyme Numbers (IUBMB) for ADAM29 Gene

Gene Ontology (GO) - Molecular Function for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10512762
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM29: view

Phenotypes for ADAM29 Gene

genes like me logo Genes that share phenotypes with ADAM29: view

Animal Model Products

CRISPR Products

miRNA for ADAM29 Gene

miRTarBase miRNAs that target ADAM29

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM29

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAM29 Gene

Localization for ADAM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM29 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM29 Gene COMPARTMENTS Subcellular localization image for ADAM29 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view

Pathways for ADAM29 Gene

SuperPathways for ADAM29 Gene

No Data Available

Interacting Proteins for ADAM29 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352177%0d%0a9606.ENSP00000285928%0d%0a9606.ENSP00000246194%0d%0a
Selected Interacting proteins: Q9UKF5-ADA29_HUMAN ENSP00000352177 for ADAM29 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view

No data available for Pathways by source for ADAM29 Gene

Transcripts for ADAM29 Gene

Unigene Clusters for ADAM29 Gene

ADAM metallopeptidase domain 29:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM29

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM29
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM29 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - -

Relevant External Links for ADAM29 Gene

GeneLoc Exon Structure for
ADAM29
ECgene alternative splicing isoforms for
ADAM29

Expression for ADAM29 Gene

mRNA expression in normal human tissues for ADAM29 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM29 Gene

This gene is overexpressed in Testis (47.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM29 Gene

SOURCE GeneReport for Unigene cluster for ADAM29 Gene Hs.126838

mRNA Expression by UniProt/SwissProt for ADAM29 Gene

Q9UKF5-ADA29_HUMAN
Tissue specificity: Expressed specifically in testes
genes like me logo Genes that share expressions with ADAM29: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM29 Gene

Orthologs for ADAM29 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM29 35
  • 98.82 (n)
  • 98.54 (a)
ADAM29 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
OneToMany
ADAM29 35
  • 76.59 (n)
  • 64.38 (a)
dog
(Canis familiaris)
Mammalia ADAM29 35
  • 70.55 (n)
  • 57.54 (a)
ADAM29 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam29 35
  • 70.71 (n)
  • 59.79 (a)
Adam29 16
Adam29 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Neu3 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for ADAM29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM29 Gene

ENSEMBL:
Gene Tree for ADAM29 (if available)
TreeFam:
Gene Tree for ADAM29 (if available)

Paralogs for ADAM29 Gene

Selected SIMAP similar genes for ADAM29 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADAM29 Gene

genes like me logo Genes that share paralogs with ADAM29: view

Variants for ADAM29 Gene

Sequence variations from dbSNP and Humsavar for ADAM29 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1104945 -- 174,918,281(+) AATAA(A/C)CCTCA upstream-variant-2KB
rs3924572 -- 174,963,667(-) TTGTC(C/T)TTCAA intron-variant
rs4072805 -- 174,918,134(+) CATTG(C/G)ATAAA upstream-variant-2KB
rs4128922 -- 174,968,976(-) AAAAA(C/T)ACGAA intron-variant
rs4128923 -- 174,968,824(-) CACGA(C/T)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM29 Gene

Variant ID Type Subtype PubMed ID
nsv830156 CNV Gain 17160897
nsv881126 CNV Loss 21882294

Relevant External Links for ADAM29 Gene

HapMap Linkage Disequilibrium report
ADAM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM29 Gene

Disorders for ADAM29 Gene

UniProtKB/Swiss-Prot

ADA29_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

No disorders were found for ADAM29 Gene.

Publications for ADAM29 Gene

  1. Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4. (PMID: 10644455) Xu R. … Li C. (Genomics 1999) 2 3 4 23
  2. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. (PMID: 15802535) Oppezzo P. … Davi F. (Blood 2005) 3 23
  3. Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. (PMID: 10512762) Cerretti D.P. … Nelson N. (Biochem. Biophys. Res. Commun. 1999) 3 4
  4. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X. … Samuels Y. (Hum. Mutat. 2011) 3 4
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3

Products for ADAM29 Gene

Sources for ADAM29 Gene

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