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ADAM28 Gene

protein-coding   GIFtS: 55
GCID: GC08P024151

ADAM Metallopeptidase Domain 28

(Previous name: a disintegrin and metalloproteinase domain 28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 281 2     MDC-Ls2
MDCL2 3 5     Disintegrin And Metalloproteinase Domain-Containing Protein 282
Epididymal Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich
Protein II2 3
     eMDCII2
ADAM232 3     Epididymial Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich
Protein II2
MDC-L2 3     Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein-L2
ADAM 282 3     EC 3.4.24.-3
EMDC II2 3     Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein L3
A Disintegrin And Metalloproteinase Domain 281     EC 3.4.248
MDC-Lm2     

External Ids:    HGNC: 2061   Entrez Gene: 108632   Ensembl: ENSG000000429807   OMIM: 6061885   UniProtKB: Q9UKQ23   

Export aliases for ADAM28 gene to outside databases

Previous GC identifers: GC08P023884 GC08P024505 GC08P024173 GC08P024207 GC08P022696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM28 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein.
Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while
the longer version encodes a transmembrane isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM28 Gene:
ADAM28 (ADAM metallopeptidase domain 28) is a protein-coding gene. Diseases associated with ADAM28 include epididymitis, and bladder transitional cell carcinoma. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2
Function: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may
function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in
sperm maturation

Gene Wiki entry for ADAM28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM28 gene promoter:
         C/EBPbeta   AML1a   GATA-1   FOXL1   PPAR-gamma1   PPAR-gamma2   ZID   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM28 promoter sequence
   Search Chromatin IP Primers for ADAM28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

ADAM28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM28 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P024151:  view genomic region     (about GC identifiers)

Start:
24,151,553 bp from pter      End:
24,216,531 bp from pter
Size:
64,979 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 28 precursor  
Size: 775 amino acids; 87148 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: B2RMV5 Q9Y339 Q9Y3S0
Alternative splicing: 2 isoforms:  Q9UKQ2-1   Q9UKQ2-2   

Explore the universe of human proteins at neXtProt for ADAM28: NX_Q9UKQ2

Explore proteomics data for ADAM28 at MOPED

Post-translational modifications: 

  • Pro-domain removal and maturation may be, at least in part, autocatalytic (By similarity)1
  • Glycosylation2 at Asn268, Asn275, Asn557, Asn602, Asn628
  • 2 DME Specific Peptides for ADAM28 (Q9UKQ2)
     MAHEMGH  GEDCDCG 


    See ADAM28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055080.2  NP_068547.2  

    ENSEMBL proteins: 
     ENSP00000265769   ENSP00000431108   ENSP00000430085   ENSP00000393699   ENSP00000429484  
     ENSP00000430094   ENSP00000443743   ENSP00000380770  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM28
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry Q9UKQ2

    ProtoNet protein and cluster: Q9UKQ2

    4 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA28_HUMAN, Q9UKQ2
    Function: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may
    function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in
    sperm maturation

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity IDA12777399
    GO:0008270zinc ion binding IEA--
         
    ADAM28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAM28:
     Decreased POU5F1-GFP protein e 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidADAM28 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA28_HUMAN, Q9UKQ2: Isoform 1: Cell membrane; Single-pass type I membrane protein
    ADA28_HUMAN, Q9UKQ2: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    ADAM28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM28
    Interactions:

        GeneGlobe Interaction Network for ADAM28

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ADAM28 (Q9UKQ23 ENSP000002657694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA4P136123, ENSP000003802274I2D: score=1 STRING: ENSP00000380227
    TLN1Q9Y4903I2D: score=1 
    ITGB1ENSP000003640944STRING: ENSP00000364094
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007229integrin-mediated signaling pathway ----
    GO:0007283spermatogenesis TAS10587367

    ADAM28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM28 (ADA28)

    7 DrugBank Compounds for ADAM28    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE-- --target--10592235
    2-(Thiomethylene)-4-Methylpentanoic Acid-- --target--10592235
    Batimastat-- 130370-60-4target--10592235
    Furoyl-Leucine-- --target--10592235
    GM6001-- --target--10592235
    N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic Acid-- --target--10592235
    Pyroglutamic Acid-- 98-79-3target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM28 gene (2 alternative transcripts): 
    NM_014265.4  NM_021777.3  

    Unigene Cluster for ADAM28:

    ADAM metallopeptidase domain 28
    Hs.174030  [show with all ESTs]
    Unigene Representative Sequence: AK225921
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265769(uc003xdy.3 uc011laa.2 uc010lua.3) ENST00000523379
    ENST00000520448 ENST00000437154(uc003xdx.3) ENST00000523440 ENST00000518516
    ENST00000521110 ENST00000521629 ENST00000523236 ENST00000518326 ENST00000520665
    ENST00000518737 ENST00000540823(uc011kzz.2) ENST00000397649
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ADAM28:
    hsa-miR-3156-5p hsa-miR-491-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidADAM28 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF137334.1 AF137335.1 AJ242015.1 AK225921.1 AK293382.1 AK303437.1 BC136478.1 BC144140.1 

    8 DOTS entries:

    DT.70105277  DT.91742911  DT.40197826  DT.423292  DT.95256522  DT.98082877  DT.70102581  DT.99999229 

    Selected AceView cDNA sequences (see all 43):

    AI393447 AI624552 AF137334 BM459284 AF137335 NM_014265 NM_021778 BQ045321 
    BF062477 AA648830 AI927716 BM560443 BQ027565 AA479710 AJ242015 NM_021777 
    BU607451 BU687111 AI475787 BQ028158 AI624420 AW298323 AI825379 AI696897 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM28 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
    SP1:                                                                                                                                -                 -     -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                            -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 19 ^ 20 ^ 21
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ADAM28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAM28 Expression
    About this image


    ADAM28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    ADAM28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.174030

    UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2
    Tissue specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small
    intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this
    protein in these tissues. Isoform 2 is expressed preferentially in spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM28 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam281 , 5 a disintegrin and metallopeptidase domain 281, 5 77.88(n)1
    70.86(a)1
      14 (35.69 cM)5
    135221  NM_001048175.21  NP_001041640.11 
     686060275 
    chicken
    (Gallus gallus)
    Aves ADAM281 ADAM metallopeptidase domain 28 58.46(n)
    48.26(a)
      419529  XM_001233495.2  XP_001233496.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    42(a)
    1 → many
    GL343422.1(136760-191906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adam71 ADAM metallopeptidase domain 7 54.36(n)
    46.03(a)
      100488450  NM_001246204.1  NP_001233133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adam286
    a disintegrin and metallopeptidase domain 28
    42(a)
    1 → many
    5(29542775-29565255) ENSDARG00000035514


    ENSEMBL Gene Tree for ADAM28 (if available)
    TreeFam Gene Tree for ADAM28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM28 gene
    ADAM72  ADAM192  ADAM122  ADAM332  ADAM302  ADAM292  ADAM202  ADAM212  
    ADAM92  ADAM152  ADAM82  
    14 SIMAP similar genes for ADAM28 using alignment to 7 protein entries:     ADA28_HUMAN (see all proteins):
    ADAMDEC1    ADAM7    ADAM8    ADAM9    ADAM19    ADAM2
    ADAM12    ADAM15    ADAM11    ADAM22    ADAM33    ADAM23
    ADAM18    ADAM20

    ADAM28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM28 (see all 1633)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663174
    A cutaneous metastatic melanoma sample4--see VAR_0663172 G E mis40--------
    VAR_0663184
    A cutaneous metastatic melanoma sample4--see VAR_0663182 G E mis40--------
    VAR_0663204
    A cutaneous metastatic melanoma sample4--see VAR_0663202 S F mis40--------
    VAR_0663214
    A cutaneous metastatic melanoma sample4--see VAR_0663212 G D mis40--------
    VAR_0663194
    A cutaneous metastatic melanoma sample4--see VAR_0663192 G E mis40--------
    rs1492328601,2
    C--22710475(+) CTTCA-/TCTTTCCTT
    CCATCCATAATC
    TTTAT
    2 -- int10--------
    rs778888931,2
    C--22719115(+) ACTAA-/GGGAGG 2 -- int10--------
    rs101124441,2
    --22728017(+) aaaaaA/Ccaaaa 2 -- int10--------
    rs101124451,2
    --22728018(+) aaaacA/Caaaaa 2 -- int10--------
    rs1389330611,2
    C--22740346(+) ATGGA-/TTAG  
            
    TTAAA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ADAM28 (24151553 - 24216531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADAM28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673011CNV Deletion23128226
    nsv6120CNV Loss18451855
    nsv831271CNV Gain17160897
    nsv890682CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM28
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606188    OMIM disorders: --

    15 diseases for ADAM28:    
    About MalaCards
    epididymitis    bladder transitional cell carcinoma    transitional cell carcinoma    chondrosarcoma
    lung adenocarcinoma    periodontitis    liver disease    schizophrenia
    adenocarcinoma    melanoma    squamous cell carcinoma    lung cancer
    endotheliitis    colorectal cancer    hepatitis


    ADAM28 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ADAM28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 20 19601836 (2), 15013428 (1), 17355265 (1)

    Genetic Association Database (GAD): ADAM28
    Human Genome Epidemiology (HuGE) Navigator: ADAM28 (1 document)

    Export disorders for ADAM28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM28 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with ADAM28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes. (PubMed id 10506182)1, 2, 9 Roberts C.M.... Bowditch R.D. (J. Biol. Chem. 1999)
    2. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    3. Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis. (PubMed id 10587367)1, 2 Jury J.A.... Hall L. (Mol. Hum. Reprod. 1999)
    4. The regulatory role of a disintegrin and metalloproteinase 28 on the biologic property of human periodontal ligament stem cells. (PubMed id 20450360)1, 9 Zhao Z....Liu H. (J. Periodontol. 2010)
    5. ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. (PubMed id 17047053)1, 9 Mitsui Y....Okada Y. (Cancer Res. 2006)
    6. The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1. (PubMed id 11724793)1, 9 Bridges L.C....Bowditch R.D. (J. Biol. Chem. 2002)
    7. ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. (PubMed id 15013428)1, 9 Mochizuki S....Okada Y. (Biochem. Biophys. Res. Commun. 2004)
    8. Integrin alpha4beta1-dependent adhesion to ADAM 28 (MDC-L) requires an extended surface of the disintegrin domain. (PubMed id 12667064)1, 9 Bridges L.C....Bowditch R.D. (Biochemistry 2003)
    9. Localization of the gene for hyperostosis cranialis interna to chromosome 8p21 with analysis of three candidate genes. (PubMed id 23640157)1 Borra V.M....Van Hul W. (Calcif. Tissue Int. 2013)
    10. Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report. (PubMed id 23527725)1 Nowakowska-Zajdel E....Muc-Wierzgon M. (Int J Immunopathol Pharmacol 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10863 HGNC: 206 AceView: ADAM28 Ensembl:ENSG00000042980 euGenes: HUgn10863
    ECgene: ADAM28 H-InvDB: ADAM28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM28 gene:
    Search GeneIP for patents involving ADAM28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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