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Aliases for ADAM28 Gene

Aliases for ADAM28 Gene

  • ADAM Metallopeptidase Domain 28 2 3 5
  • Epididymal Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3 4
  • ADAM 28 3 4
  • EMDC II 3 4
  • MDC-L 3 4
  • MDCL 3 4
  • Epididymial Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein II 3
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein-L 3
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein L 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 28 3
  • A Disintegrin And Metalloproteinase Domain 28 2
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • EMDCII 3
  • ADAM23 4

External Ids for ADAM28 Gene

Previous GeneCards Identifiers for ADAM28 Gene

  • GC08P023884
  • GC08P024505
  • GC08P024173
  • GC08P024207
  • GC08P022696
  • GC08P024151

Summaries for ADAM28 Gene

Entrez Gene Summary for ADAM28 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ADAM28 Gene

ADAM28 (ADAM Metallopeptidase Domain 28) is a Protein Coding gene. Diseases associated with ADAM28 include Hyperostosis Cranialis Interna. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot for ADAM28 Gene

  • May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Gene Wiki entry for ADAM28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM28 Gene

Genomics for ADAM28 Gene

Regulatory Elements for ADAM28 Gene

Enhancers for ADAM28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F024293 1 FANTOM5 Ensembl ENCODE 19.7 +2.1 2077 5.4 ELF3 ZNF48 ZBTB40 ETS1 ETV6 FOS SP3 CEBPB JUNB TBX21 ADAM28 ADAMDEC1
GH08F024347 0.3 FANTOM5 19.6 +53.7 53746 0.4 TAF1 FOS ADAM28 ENSG00000253535 ADAMDEC1
GH08F024366 0.8 FANTOM5 Ensembl ENCODE 19.6 +73.2 73196 1.7 MTA2 ZBED1 CBFB JUNB TBX21 CBX5 EED NBN MLLT1 CREM ADAM28 ENSG00000253535 ADAMDEC1
GH08F024334 0.7 FANTOM5 13.2 +41.0 40993 0.3 ADAM28 ADAMDEC1
GH08F024383 1.3 FANTOM5 ENCODE 10.3 +92.4 92388 5.4 CTCF PKNOX1 EBF1 RAD21 TEAD3 RELA ZNF547 ZNF143 SMC3 CHD2 ADAMDEC1 ADAM28 ADAM7 PIR51295
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAM28 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001899483 460 1001 ELF3 CTCF SOX13 CEBPG ZNF48 ZNF644 ETS1 TEAD3 ETV6 GATAD2A

Genomic Location for ADAM28 Gene

Chromosome:
8
Start:
24,294,040 bp from pter
End:
24,359,018 bp from pter
Size:
64,979 bases
Orientation:
Plus strand

Genomic View for ADAM28 Gene

Genes around ADAM28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM28 Gene

Proteins for ADAM28 Gene

  • Protein details for ADAM28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKQ2-ADA28_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 28
    Protein Accession:
    Q9UKQ2
    Secondary Accessions:
    • B2RMV5
    • Q9Y339
    • Q9Y3S0

    Protein attributes for ADAM28 Gene

    Size:
    775 amino acids
    Molecular mass:
    87148 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM28 Gene

Selected DME Specific Peptides for ADAM28 Gene

Q9UKQ2:
  • GEDCDCG
  • MAHEMGH

Post-translational modifications for ADAM28 Gene

  • Pro-domain removal and maturation may be, at least in part, autocatalytic.
  • Glycosylation at Asn 268, Asn 275, Asn 557, Asn 602, and Asn 628
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADAM28
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADAM28

Domains & Families for ADAM28 Gene

Gene Families for ADAM28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKQ2

UniProtKB/Swiss-Prot:

ADA28_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM28: view

Function for ADAM28 Gene

Molecular function for ADAM28 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Enzyme Numbers (IUBMB) for ADAM28 Gene

Gene Ontology (GO) - Molecular Function for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,IDA 12777399
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAM28: view
genes like me logo Genes that share phenotypes with ADAM28: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM28 Gene

Localization for ADAM28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM28 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM28 Gene COMPARTMENTS Subcellular localization image for ADAM28 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM28: view

Pathways & Interactions for ADAM28 Gene

SuperPathways for ADAM28 Gene

No Data Available

Interacting Proteins for ADAM28 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265769%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000380227%0d%0a9606.ENSP00000293813%0d%0a
Selected Interacting proteins: Q9UKQ2-ADA28_HUMAN ENSP00000265769 for ADAM28 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADAM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis TAS 10587367
genes like me logo Genes that share ontologies with ADAM28: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM28 Gene

Drugs & Compounds for ADAM28 Gene

(7) Drugs for ADAM28 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE Experimental Pharma Target 0
2-(Thiomethylene)-4-Methylpentanoic Acid Experimental Pharma Target 0
Batimastat Experimental Pharma Target Potent, broad spectrum MMP inhibitor 0
Furoyl-Leucine Experimental Pharma Target 0
GM6001 Experimental Pharma Target 0
genes like me logo Genes that share compounds with ADAM28: view

Transcripts for ADAM28 Gene

Unigene Clusters for ADAM28 Gene

ADAM metallopeptidase domain 28:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM28 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: -
SP8: - -
SP9:

ExUns: 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ADAM28 Gene

GeneLoc Exon Structure for
ADAM28
ECgene alternative splicing isoforms for
ADAM28

Expression for ADAM28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM28 Gene

This gene is overexpressed in Stomach (x8.5) and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for ADAM28 Gene

This gene is overexpressed in Liver, secretome (51.5) and Heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM28 Gene



Protein tissue co-expression partners for ADAM28 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM28 Gene:

ADAM28

SOURCE GeneReport for Unigene cluster for ADAM28 Gene:

Hs.174030

mRNA Expression by UniProt/SwissProt for ADAM28 Gene:

Q9UKQ2-ADA28_HUMAN
Tissue specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
genes like me logo Genes that share expression patterns with ADAM28: view

Primer Products

Orthologs for ADAM28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM28 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM28 34 35
  • 86.35 (n)
cow
(Bos Taurus)
Mammalia ADAM28 34 35
  • 81.66 (n)
rat
(Rattus norvegicus)
Mammalia Adam28 34
  • 78.45 (n)
mouse
(Mus musculus)
Mammalia Adam28 34 16 35
  • 77.88 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM28 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM28 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM28 34
  • 58.46 (n)
-- 35
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adam7 34
  • 54.36 (n)
zebrafish
(Danio rerio)
Actinopterygii adam28 35
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mmd 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for ADAM28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM28 Gene

ENSEMBL:
Gene Tree for ADAM28 (if available)
TreeFam:
Gene Tree for ADAM28 (if available)

Paralogs for ADAM28 Gene

genes like me logo Genes that share paralogs with ADAM28: view

Variants for ADAM28 Gene

Sequence variations from dbSNP and Humsavar for ADAM28 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs267601860 A cutaneous metastatic melanoma sample 24,313,405(+) TCAGG(A/G)GGATC intron-variant, nc-transcript-variant, reference, missense
rs267601862 A cutaneous metastatic melanoma sample 24,332,727(+) ATTAG(A/G)AGAAT intron-variant, nc-transcript-variant, reference, missense
rs267601864 A cutaneous metastatic melanoma sample 24,335,579(+) GAAGG(A/G)CCACT intron-variant, nc-transcript-variant, reference, missense
VAR_066317 A cutaneous metastatic melanoma sample
VAR_066320 A cutaneous metastatic melanoma sample

Structural Variations from Database of Genomic Variants (DGV) for ADAM28 Gene

Variant ID Type Subtype PubMed ID
esv2673011 CNV deletion 23128226
esv3616651 CNV loss 21293372
esv3616652 CNV loss 21293372
esv3891377 CNV loss 25118596
nsv610781 CNV loss 21841781
nsv6120 CNV deletion 18451855
nsv831271 CNV gain 17160897

Variation tolerance for ADAM28 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM28 Gene

Disorders for ADAM28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hyperostosis cranialis interna
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAM28

Genetic Association Database (GAD)
ADAM28
Human Genome Epidemiology (HuGE) Navigator
ADAM28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM28
genes like me logo Genes that share disorders with ADAM28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM28 Gene

Publications for ADAM28 Gene

  1. MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes. (PMID: 10506182) Roberts C.M. … Bowditch R.D. (J. Biol. Chem. 1999) 3 4 22 64
  2. The regulatory role of a disintegrin and metalloproteinase 28 on the biologic property of human periodontal ligament stem cells. (PMID: 20450360) Zhao Z. … Liu H. (J. Periodontol. 2010) 3 22 64
  3. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PMID: 19054571) GregA^rio S.P. … Dias-Neto E. (Psychiatry Res 2009) 3 46 64
  4. ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. (PMID: 17047053) Mitsui Y. … Okada Y. (Cancer Res. 2006) 3 22 64
  5. ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. (PMID: 15013428) Mochizuki S. … Okada Y. (Biochem. Biophys. Res. Commun. 2004) 3 22 64

Products for ADAM28 Gene

Sources for ADAM28 Gene

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