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ADAM28 Gene

protein-coding GIFtS: 56

GC08P024207

ADAM metallopeptidase domain 28
(Previous name: a disintegrin and metalloproteinase domain 28 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADAM23 ^¹, ², ³
EC 3.4.24.- ^³
MDC-L ^³
MDC-Lm ^¹, ²
MDC-Ls ^¹, ²
MDCL ^², ³, ⁵
eMDCII ^¹, ²

Descriptions
ADAM 28 ^³
ADAM metallopeptidase domain 28 ^²
Epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II ^³
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L ^³
a disintegrin and metalloproteinase domain 28 ^¹, ²
eMDC II ^³
metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L ^²

External Ids
HGNC: 206¹
Entrez Gene: 10863²
UniProtKB: Q9UKQ2³
Ensembl: ENSG00000042980⁷

Search outside databases for aliases for ADAM28 gene

Previous GC identifers: GC08P023884 GC08P024505 GC08P024173

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADAM28:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members

of this family are membrane-anchored proteins structurally related to snake venom disintegrins,

and have been implicated in a variety of biological processes involving cell-cell and cell-matrix

interactions, including fertilization, muscle development, and neurogenesis. The protein encoded

by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two

transcript variants. The shorter version encodes a secreted isoform, while the longer version

encodes a transmembrane isoform. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2

Function: May play a role in the adhesive and proteolytic events that occur during lymphocyte

emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as

FASL and CD40L. May be involved in sperm maturation

Gene Wiki entry for ADAM28

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM28 gene

Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2

ADAM28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P024207: (about GC identifiers)

Start:	24,207,525 bp from pter
End:	24,273,005 bp from pter
Size:	65,481 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_023666.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 28 precursor

Size: 775 amino acids; 87181 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Secondary accessions: Q9Y339 Q9Y3S0

Alternative splicing: 2 isoforms: Q9UKQ2-1 Q9UKQ2-2

Post-translational modifications:

Pro-domain removal and maturation may be, at least in part, autocatalytic (By similarity)¹

REFSEQ proteins (2 alternative transcripts):

NP_055080.2 NP_068547.2

ENSEMBL proteins:

ENSP00000380770 ENSP00000265769

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM28)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ADAM28:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADAM28), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ADAM28

Assays for ADAM28:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UKQ2

ProtoNet protein and cluster: Q9UKQ2

4 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006210 Type I EGF

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM28)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM28)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014265

Applied Biosystems Silencer® siRNAs for ADAM28

Sigma-Aldrich siRNA and siRNA Panels for ADAM28

Sigma-Aldrich shRNA for ADAM28

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014265
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014265
untagged cDNA clones in CMV expression vector (see all 2): NM_014265

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014265

UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2

Function: May play a role in the adhesive and proteolytic events that occur during lymphocyte

emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as

FASL and CD40L. May be involved in sperm maturation

Enzyme Number (IUBMB): EC 3.4.24.-

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM28 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks ADAM28 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADAM28

3 Interacting proteins for ADAM28 (ENSP00000265769³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SELP	ENSP00000263686³	STRING (score=.861)
ITGA4	ENSP00000233573³	STRING (score=.773)
MMP25	ENSP00000337816³	STRING (score=.766)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007283	spermatogenesis	TAS	10587367

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ADAM28

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM28

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM28)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM28)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014265

Sigma-Aldrich siRNA and siRNA Panels for ADAM28

Sigma-Aldrich shRNA for ADAM28

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014265 NM_021777

REFSEQ mRNAs for ADAM28 gene (2 alternative transcripts):

NM_014265.4 NM_021777.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014265 NM_021777

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014265
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014265
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014265

Additional cDNA sequence:

AF137334.1 AF137335.1 AJ242015.1 AK225921.1 AK293382.1 AK303437.1 BC136478.1 BC144140.1

8 DOTS entries:

DT.70105277 DT.91742911 DT.40197826 DT.423292 DT.95256522 DT.98082877 DT.70102581 DT.99999229

24/43 AceView cDNA sequences (see all 43 ):

AI624552 AI393447 BQ027565 AI927716 BM560443 BQ045321 BU607451 AF137334

AA648830 NM_014265 NM_021777 NM_021778 BM459284 AJ242015 BF062477 AA479710

BU687111 AF137335 AI475787 AI696897 AA280392 AI825379 BI756263 AI301513

highest scoring ESTs for ADAM28:

AJ242015 AA479710 AA648830 AF137334 AI393447 AI470208 AI624552 AI921914 AI927716 BE169428

Unigene Cluster for ADAM28:

ADAM metallopeptidase domain 28

Hs.174030 [show with all ESTs]

Unigene Representative Sequence: AK225921

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM28 (see all 9 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18a	·	18b	·	18c	^
SP1:																																											-						-		-
SP2:
SP3:
SP4:															-
SP5:															-

ExUns:	19	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ADAM28

2 Ensembl transcripts including schematic representations:

ENST00000397649 ENST00000265769

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADAM28 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM28

¹ / ² / ³

7 probe-sets matching ADAM28 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35479_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AJ242015	1.00	1.00	1.00	1
205997_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021778	0.20	1.00	0.72	1
208268_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021777	0.60	1.00	0.82	1
208269_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021777	0.60	1.00	0.82	1
205997_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208268_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208269_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADAM28 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.174030
Expression variation in blood from EXPOLDB for ADAM28
UniProtKB/Swiss-Prot: ADA28_HUMAN, Q9UKQ2
Tissue specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node,
spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is
responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially
in spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADAM28 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAM28¹	--	ADAM metallopeptidase domain 28	86.53(n) 83.92(a)	608753 XM_845863.1 XP_850956.1
chimpanzee (Pan troglodytes)	ADAM28¹	--	ADAM metallopeptidase domain 28	98.62(n) 97.81(a)	464061 XM_519663.2 XP_519663.2
cow (Bos taurus)	ADAM28¹	--	ADAM metallopeptidase domain 28	81.43(n) 75.17(a)	507019 XM_583562.3 XP_583562.3
rat (Rattus norvegicus)	Adam28¹	--	ADAM metallopeptidase domain 28	78.4(n) 72.99(a)	290344 NM_181693.1 NP_859044.1
mouse (Mus musculus)	Adam28^{1, 5}	14 (30.72 cM)⁵	a disintegrin and metallopeptidase domain 28^{1, 5}	77.86(n)¹ 70.98(a)¹	13522¹ NM_001048175.1¹ NP_001041640.1¹ AF153350⁵ AF163290⁵ (see all 17)

About this table Species with no ortholog for ADAM28

ENSEMBL Gene Tree for ADAM28

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADAM28 gene

ADAM7² ADAM8² ADAMDEC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/397 NCBI SNPs in ADAM28 are shown (see all 397 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 186)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1058914^1,2	C,F,H,O	24267985(-)	`CAGAAA/GATGTT`	1	--	ut3¹ ese³		17		EA NA MN EU WA	2790
	rs7004152^1,2	A,C,F,H	24207250(+)	`TGTCTA/GGCATG`	2	--	ng5¹		7		EU EA WA NA	560
	rs6982284^1,2	A,C,F,H	24249133(+)	`ATGTGC/TGAAGG`	2	A/V	mis¹ int¹		8		EU EA WA	826
	rs7829965^1,2	A,C,F,H	24263383(+)	`GCTATG/AGTAAT`	1	I/M	mis¹		13		EU EA WA NA	1330
	rs7814768^1,2	A,C,F,H	24267276(+)	`ATCCAA/GTGTCT`	1	V/M	mis¹ ese³		12		NA EU EA WA	1048
	rs7001647^1,2	A,C,F,H	24249010(+)	`AGTCAA/GTGGCT`	2	N/S	mis¹ ese³		9		EU EA WA NA	914
	rs9314282^1,2	A,C,F,H	24234683(+)	`TAAAAG/TGTACA`	2	R/M	mis¹ ese³		9		EU EA WA NA	910
	rs5023740^1,2	A,C,H	24268867(+)	`ATCTAG/TCTCAG`	1	--	ng3¹		4		EU EA WA	410
	rs4872222^1,2	C,F,H	24249209(+)	`AGCTTC/TGAACT`	2	--	int¹ ut3¹		8		EU EA WA	836
--	rs12678164^1,2	A,C	24205555(+)	`aggtgA/Cccacc`	2	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ADAM28 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606188

1 Novoseek disease relationship for ADAM28 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	2	15013428 (1), 17355265 (1)

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Human Genome Epidemiology Navigator: ADAM28 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/21 PubMed articles for ADAM28 gene (see all 21 ):

MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes. (PubMed id 10506182)^{1, 3, 4} Roberts C.M.... Bowditch R.D. (1999)
Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis. (PubMed id 10587367)^{3, 4} Jury J.A.... Hall L. (1999)
ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. (PubMed id 17047053)^{1, 3} Mitsui Y....Okada Y. (2006)
The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1. (PubMed id 11724793)^{1, 3} Bridges L.C....Bowditch R.D. (2002)
ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. (PubMed id 15013428)^{1, 3} Mochizuki S....Okada Y. (2004)
Integrin alpha4beta1-dependent adhesion to ADAM 28 (MDC-L) requires an extended surface of the disintegrin domain. (PubMed id 12667064)^{1, 3} Bridges L.C....Bowditch R.D. (2003)
Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)³ GregA^rio S.P....Dias-Neto E. (2009)
Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs). (PubMed id 18690470)³ Zhao Z....Jin Y. (2008)
Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells. (PubMed id 17597069)³ Shimoda M....Okada Y. (2007)
ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. (PubMed id 16052521)³ Ohtsuka T....Okada Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10863	HGNC: 206	AceView: ADAM28	Ensembl:ENSG00000042980	euGenes: HUgn10863
ECgene: ADAM28	H-InvDB: ADAM28

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADAM28
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADAM28:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM28-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM28		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM28		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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ADAM28 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for ADAM28

Summaries
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Genomic Location
for ADAM28

Proteins
for ADAM28

Protein Domains/
Families
for ADAM28

Gene Function
for ADAM28

Pathways & Interactions
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Drugs & Compounds
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Transcripts
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Expression
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Genome Databases showing ADAM28

Other Databases showing ADAM28

Specialized Databases showing ADAM28

Licensable Technologies
for ADAM28

Services
for ADAM28

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM28 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor ADAM28

Summariesfor ADAM28

Genomic Locationfor ADAM28

Proteinsfor ADAM28

Protein Domains/Familiesfor ADAM28

Gene Functionfor ADAM28

Pathways & Interactionsfor ADAM28

Drugs & Compoundsfor ADAM28

Transcriptsfor ADAM28

Expression for ADAM28

Orthologsfor ADAM28

Paralogsfor ADAM28

SNPs/Variantsfor ADAM28

Disorders & Mutationsfor ADAM28

Medical Newsfor ADAM28

Publicationsfor ADAM28

Search for ADAM28

Genome Databases showing ADAM28

Other Databases showing ADAM28

Specialized Databases showing ADAM28

Licensable Technologiesfor ADAM28

Servicesfor ADAM28

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM28

Summaries
for ADAM28

Genomic Location
for ADAM28

Proteins
for ADAM28

Protein Domains/
Families
for ADAM28

Gene Function
for ADAM28

Pathways & Interactions
for ADAM28

Drugs & Compounds
for ADAM28

Transcripts
for ADAM28

Expression
for ADAM28

Orthologs
for ADAM28

Paralogs
for ADAM28

SNPs/Variants
for ADAM28

Disorders & Mutations
for ADAM28

Medical News
for ADAM28

Publications
for ADAM28

Licensable Technologies
for ADAM28

Services
for ADAM28