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Aliases & Descriptions for ADAM23
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MDC-3 3 | | MDC3 1, 2, 3, 5 |
| | | Descriptions |
|---|
| ADAM 23 3 | | ADAM metallopeptidase domain 23 2 | Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 3 | | a disintegrin and metalloproteinase domain 23 1, 2 |
|
| | Search outside databases for aliases for ADAM23 genePrevious GC identifers: GC02P205525 GC02P206032 GC02P207272 GC02P207510 GC02P207133 |
Summaries for ADAM23(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ADAM23: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. [provided by RefSeq] UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like proteinGene Wiki entry for ADAM23 |
Genomic Location for ADAM23
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ADAM23 gene 
Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33ADAM23 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P207018:
(about GC identifiers)
Start:
|
207,016,613 bp from pter |
End:
|
207,191,124 bp from pter |
Size:
|
174,512 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for ADAM23
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 23 precursor Size: 832 amino acids; 91926 Da
Subunit: Ligand for integrin alpha-V/beta-3
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform Gamma: Secreted
Developmental stage: Highly expressed in the fetal brainAlternative splicing: 3 isoforms: O75077-1 O75077-2 O75077-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003803.1
ENSEMBL proteins: ENSP00000363537 ENSP00000264377 ENSP00000363536
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ADAM23: Assays for ADAM23: | Protein
Domains/ Families for ADAM23(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75077
ProtoNet protein and cluster: O75077 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077Domain: A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptorSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain | Gene Function for ADAM23
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003812
Applied Biosystems Silencer® siRNAs for ADAM23
Sigma-Aldrich siRNA and siRNA Panels for ADAM23  Sigma-Aldrich shRNA for ADAM23  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003812                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003812                                  untagged cDNA clone in CMV expression vector: NM_003812 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003812
UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like proteinGenatlas biochemistry entry for ADAM23:a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adam23):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ADAM23
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM23 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for ADAM23 (O750772) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for ADAM23(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for ADAM23 |
Browse Tocris compounds for ADAM23 1 Novoseek chemical compound relationship for ADAM23 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mdc-2 |
96.18 |
7 |
9693107 (4), 10433968 (2) |
About this table
|
Transcripts for ADAM23(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003812
Sigma-Aldrich siRNA and siRNA Panels for ADAM23  Sigma-Aldrich shRNA for ADAM23  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003812 REFSEQ mRNAs for ADAM23 gene: NM_003812.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003812               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003812                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003812                                  untagged cDNA clone in CMV expression vector: NM_003812  Additional cDNA sequence: AB009672.1 AJ005580.1 AK091800.1 AK129906.1 AK296844.1 BC132763.1 BC132765.1 4 DOTS entries: DT.438074 DT.413587 DT.436884 DT.95162339 24/62 AceView cDNA sequences (see all 62
):F13545 BI019680 BX500284 NM_003812 BM676690 AJ005580 BI019679 BE502515 AA961921 BM714987 BX437404 AK129906 AI692184 N90403 AA317222 AB009672 AA814554 AW005792 BF691008 BX116174 AW303311 AI377727 AA814638 AW129109
highest scoring ESTs for ADAM23:AB009672 AA723972 AI342396 AJ005580 AK129906 BM714987 BX500284 AA317222 AA814638 AI692184 Unigene Cluster for ADAM23: ADAM metallopeptidase domain 23 Hs.591643 [show with all ESTs]Unigene Representative Sequence: AK091800
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000374416
ENST00000264377
ENST00000374415
|
Expression for ADAM23
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADAM23 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADAM23
1 / 2 / 3 4 probe-sets matching ADAM23 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTATAAAAAG
SOURCE GeneReport for Unigene cluster: Hs.591643
Expression variation in blood from EXPOLDB for ADAM23 UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole |
Orthologs for ADAM23
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADAM23 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for ADAM23
ENSEMBL Gene Tree for ADAM23 | Paralogs for ADAM23(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ADAM23 gene
- ADAM112 ENSG000000082772 ADAM222
|
SNPs/Variants for ADAM23(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADAM23 (up to first 250kb)
|
Disorders & Mutations for ADAM23
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603710
|
Medical News for ADAM23(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ADAM23 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for ADAM23 gene (see all 14
):- Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 3, 4 Sagane K.... Tanaka I. (1998)
- Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PubMed id 14697522)1, 3, 4 Sun Y.P.... Zhao S. (2004)
- Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)3, 4 Tao W.A.... Aebersold R. (2005)
- ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD- independent mechanism. (PubMed id 10749942)3, 4 Cal S.... Lopez-Otin C. (2000)
- Promoter hypermethylation of the ADAM23 gene in colorectal cancer cell lines and cancer tissues. (PubMed id 19089928)3 Choi J.S....Park J.G. (2009)
- ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. (PubMed id 16103878)3 Takada H....Inazawa J. (2005)
- ADAM23 methylation and expression analysis in brain tumors. (PubMed id 15862898)3 Costa F.F....Camargo A.A. (2005)
- Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. (PubMed id 15146195)3 Schmitt-Ulms G....Baldwin M.A. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)3 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ADAM23
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ADAM23
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADAM23
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM23(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ADAM23(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ADAM23:

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Incremental update: 13 Oct 2009
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