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Aliases for ADAM23 Gene

Aliases for ADAM23 Gene

  • ADAM Metallopeptidase Domain 23 2 3
  • MDC3 3 4 6
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 3 4
  • MDC-3 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 23 3
  • A Disintegrin And Metalloproteinase Domain 23 2
  • ADAM 23 4

External Ids for ADAM23 Gene

Previous GeneCards Identifiers for ADAM23 Gene

  • GC02P205525
  • GC02P206032
  • GC02P207272
  • GC02P207510
  • GC02P207133
  • GC02P207018
  • GC02P199158

Summaries for ADAM23 Gene

Entrez Gene Summary for ADAM23 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM23 Gene

ADAM23 (ADAM Metallopeptidase Domain 23) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM23 Gene

  • May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein

Gene Wiki entry for ADAM23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM23 Gene

Genomics for ADAM23 Gene

Regulatory Elements for ADAM23 Gene

Genomic Location for ADAM23 Gene

Start:
206,443,539 bp from pter
End:
206,621,130 bp from pter
Size:
177,592 bases
Orientation:
Plus strand

Genomic View for ADAM23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM23 Gene

Proteins for ADAM23 Gene

  • Protein details for ADAM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75077-ADA23_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 23
    Protein Accession:
    O75077
    Secondary Accessions:
    • A2RU59

    Protein attributes for ADAM23 Gene

    Size:
    832 amino acids
    Molecular mass:
    91926 Da
    Quaternary structure:
    • Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.

    Alternative splice isoforms for ADAM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM23 Gene

Proteomics data for ADAM23 Gene at MOPED

Post-translational modifications for ADAM23 Gene

  • Glycosylation at Asn76, Asn96, Asn100, Asn263, Asn547, Asn548, Asn664, and Asn732
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAM23 Gene

Domains for ADAM23 Gene

Gene Families for ADAM23 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM23 Gene

Graphical View of Domain Structure for InterPro Entry

O75077

UniProtKB/Swiss-Prot:

ADA23_HUMAN :
  • O75077
Domain:
  • A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM23: view

Function for ADAM23 Gene

Molecular function for ADAM23 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain
UniProtKB/Swiss-Prot Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein

Gene Ontology (GO) - Molecular Function for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9693107
GO:0005515 protein binding IPI 20463223
GO:0008237 metallopeptidase activity TAS 9693107
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM23: view

Phenotypes for ADAM23 Gene

genes like me logo Genes that share phenotypes with ADAM23: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM23 Gene

Localization for ADAM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM23 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform Gamma: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM23 Gene COMPARTMENTS Subcellular localization image for ADAM23 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane TAS 9693107
genes like me logo Genes that share ontologies with ADAM23: view

Pathways for ADAM23 Gene

SuperPathways for ADAM23 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007417 central nervous system development TAS 9693107
genes like me logo Genes that share ontologies with ADAM23: view

No data available for Pathways by source for ADAM23 Gene

Compounds for ADAM23 Gene

(1) Novoseek inferred chemical compound relationships for ADAM23 Gene

Compound -log(P) Hits PubMed IDs
mdc-2 96.1 6
genes like me logo Genes that share compounds with ADAM23: view

Transcripts for ADAM23 Gene

Unigene Clusters for ADAM23 Gene

ADAM metallopeptidase domain 23:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM23

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM23 Gene

No ASD Table

Relevant External Links for ADAM23 Gene

GeneLoc Exon Structure for
ADAM23
ECgene alternative splicing isoforms for
ADAM23

Expression for ADAM23 Gene

mRNA expression in normal human tissues for ADAM23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM23 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.6), Brain - Nucleus accumbens (basal ganglia) (4.5), Heart - Left Ventricle (4.4), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM23 Gene

SOURCE GeneReport for Unigene cluster for ADAM23 Gene Hs.591643

mRNA Expression by UniProt/SwissProt for ADAM23 Gene

O75077-ADA23_HUMAN
Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
genes like me logo Genes that share expressions with ADAM23: view

In Situ Assay Products

Orthologs for ADAM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM23 35
  • 99.88 (n)
  • 100 (a)
ADAM23 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM23 35
  • 92.31 (n)
  • 94.23 (a)
ADAM23 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM23 35
  • 92.95 (n)
  • 95.28 (a)
ADAM23 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam23 35
  • 88.77 (n)
  • 93.84 (a)
Adam23 16
Adam23 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM23 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM23 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam23 35
  • 87.6 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves ADAM23 35
  • 77.97 (n)
  • 81.02 (a)
ADAM23 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM23 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam23 35
  • 71.57 (n)
  • 74.09 (a)
Str.12051 35
zebrafish
(Danio rerio)
Actinopterygii ADAM23 (2 of 2) 36
  • 67 (a)
OneToMany
adam23a 36
  • 63 (a)
OneToMany
wu:fj40f01 35
  • 65.73 (n)
  • 66.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 36
  • 16 (a)
OneToMany
mmd 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-71 36
  • 19 (a)
OneToMany
adm-1 37
  • 30 (a)
Species with no ortholog for ADAM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM23 Gene

ENSEMBL:
Gene Tree for ADAM23 (if available)
TreeFam:
Gene Tree for ADAM23 (if available)

Paralogs for ADAM23 Gene

Paralogs for ADAM23 Gene

genes like me logo Genes that share paralogs with ADAM23: view

Variants for ADAM23 Gene

Sequence variations from dbSNP and Humsavar for ADAM23 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs733237 -- 206,522,979(-) GTTTC(A/G)TTTCT intron-variant
rs759844 -- 206,564,144(-) ATATA(G/T)AGAGA intron-variant
rs759845 -- 206,531,504(-) AGATA(C/T)CCAAG intron-variant
rs918800 -- 206,529,224(-) CAGTA(C/T)TTAAC intron-variant
rs1013475 -- 206,562,949(-) GTCTT(C/T)CTATC intron-variant

Relevant External Links for ADAM23 Gene

HapMap Linkage Disequilibrium report
ADAM23

PCR Panel Products

  • Copy Number PCR Panels: for ADAM23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAM23 Gene

Disorders for ADAM23 Gene

Relevant External Links for ADAM23

Genetic Association Database (GAD)
ADAM23
Human Genome Epidemiology (HuGE) Navigator
ADAM23
genes like me logo Genes that share disorders with ADAM23: view

No data available for UniProtKB/Swiss-Prot for ADAM23 Gene

Publications for ADAM23 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K. … Tanaka I. (Biochem. J. 1998) 2 3 4 23
  2. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PMID: 14697522) Sun Y.P. … Zhao S. (Gene 2004) 3 4 23
  3. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD- independent mechanism. (PMID: 10749942) Cal S. … Lopez-Otin C. (Mol. Biol. Cell 2000) 3 4
  4. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira M.A. … Duffy D.L. (Allergy 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ADAM23 Gene

Sources for ADAM23 Gene

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