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ADAM23 Gene

protein-coding   GIFtS: 56
GCID: GC02P207272

ADAM Metallopeptidase Domain 23

(Previous name: a disintegrin and metalloproteinase domain 23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 231 2     A Disintegrin And Metalloproteinase Domain 231
MDC32 3 5     Disintegrin And Metalloproteinase Domain-Containing Protein 232
Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 32 3     ADAM 233
MDC-32 3     

External Ids:    HGNC: 2021   Entrez Gene: 87452   Ensembl: ENSG000001149487   OMIM: 6037105   UniProtKB: O750773   

Export aliases for ADAM23 gene to outside databases

Previous GC identifers: GC02P205525 GC02P206032 GC02P207510 GC02P207133 GC02P207018 GC02P199158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM23 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in
human cancers. (provided by RefSeq, May 2013)

GeneCards Summary for ADAM23 Gene:
ADAM23 (ADAM metallopeptidase domain 23) is a protein-coding gene. Diseases associated with ADAM23 include bruxism, and bipolar disorder. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like
protein

Gene Wiki entry for ADAM23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM23 gene promoter:
         HOXA9   HOXA9B   USF1   Brachyury   E4BP4   Meis-1b   CREB   deltaCREB   USF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM23 promoter sequence
   Search Chromatin IP Primers for ADAM23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33

ADAM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM23 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P207272:  view genomic region     (about GC identifiers)

Start:
207,308,263 bp from pter      End:
207,485,851 bp from pter
Size:
177,589 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 23 precursor  
Size: 832 amino acids; 91926 Da
Subunit: Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3
Developmental stage: Highly expressed in the fetal brain
Secondary accessions: A2RU59
Alternative splicing: 3 isoforms:  O75077-1   O75077-2   O75077-3   

Explore the universe of human proteins at neXtProt for ADAM23: NX_O75077

Explore proteomics data for ADAM23 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn76, Asn96, Asn100, Asn263, Asn547, Asn548, Asn664, Asn732
  • Modification sites at PhosphoSitePlus

  • See ADAM23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003803.1  
    ENSEMBL proteins: 
     ENSP00000264377   ENSP00000363536   ENSP00000406827   ENSP00000363537  

    ADAM23 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ADAM23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM23
    ADAM

    Selected InterPro protein domains (see all 7):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry O75077

    ProtoNet protein and cluster: O75077

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
    Domain: A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the
    integrin receptor
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA23_HUMAN, O75077
    Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like
    protein

         Genatlas biochemistry entry for ADAM23:
    a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS9693107
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity TAS9693107
    GO:0008270zinc ion binding IEA--
         
    ADAM23 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam23):
     behavior/neurological  mortality/aging 

    ADAM23 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam23tm1Lex for ADAM23

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM23
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM23
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM23

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ADAM23:
    hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidADAM23 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAM23

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    GenScript: all cDNA clones in your preferred vector: ADAM23 (NM_003812)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM23

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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA23_HUMAN, O75077: Cell membrane; Single-pass type I membrane protein (Potential)
    ADA23_HUMAN, O75077: Isoform Gamma: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane TAS9693107

    ADAM23 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ADAM23: 
              Breast Cancer in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADAM23

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ADAM23 (O750772, 3 ENSP000002643774) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-19336 I2D: score=1 STRING: ENSP00000309503
    PRNPP041563I2D: score=2 
    YWHABP319463I2D: score=1 
    MPP5ENSP000002616814STRING: ENSP00000261681
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007155cell adhesion IEA--
    GO:0007417central nervous system development TAS9693107

    ADAM23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM23 (ADA23)

    1 Novoseek inferred chemical compound relationship for ADAM23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdc-2 96.1 7 9693107 (4), 10433968 (2)



    ADAM23 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM23 gene: 
    NM_003812.3  

    Unigene Cluster for ADAM23:

    ADAM metallopeptidase domain 23
    Hs.591643  [show with all ESTs]
    Unigene Representative Sequence: AK091800
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264377(uc002vbq.3) ENST00000374415 ENST00000444281 ENST00000374416(uc010ziv.2)

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ADAM23:
    hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidADAM23 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAM23
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    GenScript: all cDNA clones in your preferred vector: ADAM23 (NM_003812)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM23
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ADAM23
      QuantiFast Probe-based Assays in human, mouse, rat ADAM23

    Additional mRNA sequence: 

    AB009672.1 AJ005580.1 AK091800.1 AK129906.1 AK296844.1 BC132763.1 BC132765.1 

    4 DOTS entries:

    DT.438074  DT.413587  DT.436884  DT.95162339 

    Selected AceView cDNA sequences (see all 62):

    BI019679 F13545 NM_003812 AW005792 BX500284 AI692184 AA317222 BX437404 
    AJ005580 BM676690 AB009672 AA961921 AK129906 N90403 BE502515 BM714987 
    BI019680 AA814554 H11006 T16244 AW129109 AW303311 F09733 BF691008 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATAAAAAG
    ADAM23 Expression
    About this image


    ADAM23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Small Pre B-Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Ovary (Reproductive System)
             Mature follicles
     
     Testis (Reproductive System)
    ADAM23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591643

    UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
    Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed
    prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole

        Pathway & Disease-focused RT2 Profiler PCR Array including ADAM23: 
              Breast Cancer in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAM23 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam231 , 5 a disintegrin and metallopeptidase domain 231, 5 88.77(n)1
    93.84(a)1
      1 (32.31 cM)5
    237921  NM_011780.21  NP_035910.11 
     634458915 
    chicken
    (Gallus gallus)
    Aves ADAM231 ADAM metallopeptidase domain 23 77.97(n)
    81.02(a)
      424099  NM_001145230.1  NP_001138702.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM236
    ADAM metallopeptidase domain 23
    74(a)
    1 ↔ 1
    GL343208.1(435056-496120)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120512 Transcribed sequence with moderate similarity to protein more 77.07(n)    BX703612.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI429326.12   -- 75.28(n)    BI429326.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mmd3 metalloendopeptidase 32(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea adm-13 Disintegrin 30(a)   III(12952834-12963248)   --


    ENSEMBL Gene Tree for ADAM23 (if available)
    TreeFam Gene Tree for ADAM23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM23 gene
    ADAM322  ADAM182  ADAM112  ADAM222  ADAM22  ADAMDEC12  
    14 SIMAP similar genes for ADAM23 using alignment to 7 protein entries:     ADA23_HUMAN (see all proteins):
    ADAM11    ADAM22    ADAM5    ADAM29    ADAM32    ADAM21
    ADAM9    ADAM7    ADAM12    ADAM15    ADAM33    ADAM19
    ADAM28    ADAM2

    ADAM23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM23 (see all 3188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356743661,2
    C--199162715(+) AGTGA-/TGAG  
            
    TGTCT
    1 -- int10--------
    rs2005357021,2
    C--199186824(+) ATCTC-/GGGGAA 1 -- int10--------
    rs1129823401,2
    C,F--199222621(+) TGGGCA/GTGGTG 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs105495061,2
    C--199292368(+) TATTT-/A/ATTT
            
    TTTAA
    1 -- int10--------
    rs2021051601,2
    C--199292368(-) AAAAAA/TAAATA 1 -- int10--------
    rs672315131,2
    C--199310052(+) AATAA-/TAAGATAA 2 -- int1 cds12Minor allele frequency- TAA:0.25NA 4
    rs1467381911,2
    C--206695851(+) CTTGTA/GCATCT 1 -- us2k10--------
    rs764364881,2
    C--206695878(+) TCTCTC/GAGGCC 1 -- us2k13Minor allele frequency- G:0.12NA EA 242
    rs1164537711,2
    C,F--206695992(+) ACTCCG/AGTGGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1850709981,2
    --206696089(+) AGCGAA/TTTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAM23 (207308263 - 207485851 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADAM23: --
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ADAM23:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing ADAM23
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603710    OMIM disorders: --

    7 diseases for ADAM23:    
    About MalaCards
    bruxism    bipolar disorder    asthma    cerebritis
    colorectal cancer    schizophrenia    breast cancer


    ADAM23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAM23
    Human Genome Epidemiology (HuGE) Navigator: ADAM23 (5 documents)

    Export disorders for ADAM23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM23 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with ADAM23)
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    1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 3, 9 Sagane K.... Tanaka I. (Biochem. J. 1998)
    2. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PubMed id 14697522)1, 2, 9 Sun Y.P.... Zhao S. (Gene 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Association and interaction analyses of eight genes under asthma linkage peaks. (PubMed id 19824886)1, 4 Ferreira M.A....Duffy D.L. (Allergy 2009)
    5. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD- independent mechanism. (PubMed id 10749942)1, 2 Cal S.... Lopez-Otin C. (Mol. Biol. Cell 2000)
    6. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (Mol. Psychiatry 2012)
    7. ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy. (PubMed id 22937229)1 Rigon L....Nobile C. (Epilepsy Res Treat 2011)
    8. The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma. (PubMed id 21429053)1 Hu C....Zhou J. (Int J Exp Pathol 2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation. (PubMed id 20851106)1 Pan Q....Li Z. (Biochem. Biophys. Res. Commun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8745 HGNC: 202 AceView: ADAM23 Ensembl:ENSG00000114948 euGenes: HUgn8745
    ECgene: ADAM23 H-InvDB: ADAM23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM23 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM23 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM23 gene:
    Search GeneIP for patents involving ADAM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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