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ADAM23 Gene

protein-coding   GIFtS: 59

GC02P207018
ADAM metallopeptidase domain 23
(Previous name: a disintegrin and metalloproteinase domain 23 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MDC-3 3
MDC3 1, 2, 3, 5
Descriptions
ADAM 23 3
ADAM metallopeptidase domain 23 2
Metalloproteinase-like, disintegrin-like, and cysteine-rich
protein 3 3
a disintegrin and metalloproteinase domain 23 1, 2
External Ids
HGNC: 2021
Entrez Gene: 87452
UniProtKB: O750773
Ensembl: ENSG000001149487
Search outside databases for aliases for ADAM23 gene

Previous GC identifers: GC02P205525 GC02P206032 GC02P207272 GC02P207510 GC02P207133

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM23:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members
of this family are membrane-anchored proteins structurally related to snake venom disintegrins,
and have been implicated in a variety of biological processes involving cell-cell and cell-matrix
interactions, including fertilization, muscle development, and neurogenesis. This gene is highly
expressed in the brain and may function as an integrin ligand in the brain. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic
metalloprotease-like protein

Gene Wiki entry for ADAM23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADAM23 gene  

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33

ADAM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P207018:     (about GC identifiers)

Start:
207,016,613 bp from pter
End:
207,191,124 bp from pter
Size:
174,512 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 23 precursor  
Size: 832 amino acids; 91926 Da
Subunit: Ligand for integrin alpha-V/beta-3
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform Gamma: Secreted
Developmental stage: Highly expressed in the fetal brain
Alternative splicing: 3 isoforms:  O75077-1   O75077-2   O75077-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003803.1  

    ENSEMBL proteins: 
    ENSP00000363537 ENSP00000264377 ENSP00000363536 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADAM23)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS9693107
    About this table

    Antibodies for ADAM23: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ADAM23
    R&D Systems Antibodies for ADAM23
    Antibodies from Abcam (ADAM23), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for ADAM23

    Assays for ADAM23: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/9 InterPro domains/families (see all 9 ):
     IPR018358 Disintegrin_CS
     IPR006586 ADAM_Cys-rich
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR000742 EGF_3
     IPR001590 Peptidase_M12B


       GeneDecks  ADAM23 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O75077

    ProtoNet protein and cluster: O75077

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
    Domain: A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the
    binding to the integrin receptor
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAM23)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003812

                  Applied Biosystems Silencer® siRNAs for ADAM23

                  Sigma-Aldrich siRNA and siRNA Panels for ADAM23  
                         Sigma-Aldrich shRNA for ADAM23  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003812
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003812
                                     untagged cDNA clone in CMV expression vector: NM_003812 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003812

    UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
    Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic
    metalloprotease-like protein

    Genatlas biochemistry entry for ADAM23:
    a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion
    protein,expressed in the brain

    2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam23):

    behavior/neurologicallethality-postnatal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0005178 integrin binding TAS9693107
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  ADAM23  (Your Favorite Gene powered by Ingenuity) 
     Axonal Guidance Signaling

       GeneDecks  ADAM23 for the pathways selected above  
    About GeneDecksing


    1 Interacting protein for ADAM23 (O750772) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042MINT-19336
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis IEA--
    GO:0007155 cell adhesion IEA--
    GO:0007417 central nervous system development TAS9693107
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADAM23
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADAM23
    1 Novoseek chemical compound relationship for ADAM23 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdc-2 96.18 7 9693107 (4), 10433968 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAM23)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003812

                  Sigma-Aldrich siRNA and siRNA Panels for ADAM23  
                         Sigma-Aldrich shRNA for ADAM23  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003812  

    REFSEQ mRNAs for ADAM23 gene: 

    NM_003812.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003812  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003812
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003812
                                     untagged cDNA clone in CMV expression vector: NM_003812 

    Additional cDNA sequence: 

    AB009672.1 AJ005580.1 AK091800.1 AK129906.1 AK296844.1 BC132763.1 BC132765.1 

    4 DOTS entries:

    DT.438074  DT.413587  DT.436884  DT.95162339 

    24/62 AceView cDNA sequences (see all 62 ):

    F13545 BI019680 BX500284 NM_003812 BM676690 AJ005580 BI019679 BE502515 
    AA961921 BM714987 BX437404 AK129906 AI692184 N90403 AA317222 AB009672 
    AA814554 AW005792 BF691008 BX116174 AW303311 AI377727 AA814638 AW129109 

    highest scoring ESTs for ADAM23:

    AB009672 AA723972 AI342396 AJ005580 AK129906 BM714987 BX500284 AA317222 AA814638 AI692184 

    Unigene Cluster for ADAM23:

    ADAM metallopeptidase domain 23
    Hs.591643  [show with all ESTs]
    Unigene Representative Sequence: AK091800


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000374416  ENST00000264377  ENST00000374415  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADAM23 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADAM23

    1 / 2 / 3

    4 probe-sets matching ADAM23 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40350_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB009672 1.00 1.00 1.00 1

    206046_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003812 0.60 1.00 0.82 1

    206046_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1559268_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ADAM23 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTATAAAAAG

    SOURCE GeneReport for Unigene cluster: Hs.591643

    Expression variation in blood from EXPOLDB for ADAM23

    UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077
    Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain,
    expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex
    and occipital pole

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ADAM23 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ADAM231   -- ADAM metallopeptidase domain 23 92.95(n)
    95.28(a)
    607871  XM_844759.1  XP_849852.1 
    chimpanzee
    (Pan troglodytes)
    ADAM231   -- ADAM metallopeptidase domain 23 99.91(n)
    100(a)
    459898  XM_516049.2  XP_516049.2 
    cow
    (Bos taurus)
    ADAM231   -- ADAM metallopeptidase domain 23 92.31(n)
    94.23(a)
    531241  XM_609728.3  XP_609728.3 
    rat
    (Rattus norvegicus)
    Adam231   -- ADAM metallopeptidase domain 23 87.68(n)
    92.03(a)
    301460  NM_001029899.1  NP_001025070.1 
    mouse
    (Mus musculus)
    Adam231, 5 1 (31.50 cM)5
    a disintegrin and metallopeptidase domain 231, 5 89.09(n)1
    94.32(a)1
    237921  NM_011780.21  NP_035910.11 
     AA2670095  AB0096735  (see all 19)
    About this table        Species with no ortholog for ADAM23

    ENSEMBL Gene Tree for ADAM23
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADAM23 gene
    ADAM112  ENSG000000082772  ADAM222  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/652 NCBI SNPs in ADAM23 are shown (see all 652 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 204)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs99171581,2
    F,H207190655(+) TACTCG/ACAGCA 1 -- ut31 ese34Minor allele frequency- A:0.01EU EA WA 416
    --
    rs102040611,2
    A207015240(+) GTGTGC/TGCGCG 1 -- ng510--------
    --
    rs14489001,2
    F207015121(+) TCACAT/CGGGGG 1 -- ng51 tfbs34Minor allele frequency- C:0.00EA NA 164
    --
    rs109321511,2
    C207016068(+) GGAAGA/GGGTTG 1 -- ng510--------
    rs37320791,2
    A,C,F,H207167712(+) GGTGCC/TCATGT 1 A/A syn1 ese314Minor allele frequency- T:0.14EA NA EU WA 3161
    rs19216661,2
    A,C,F,H,O207096781(-) TTAAAT/CTCACT 1 -- int121Minor allele frequency- C:0.38NA EA MN EU WA 3332
    rs7332371,2
    A,C,F,H,O207095948(-) GTTTCA/GTTTCT 1 -- int113Minor allele frequency- G:0.30NA EA MN EU WA 1140
    rs7598451,2
    A,C,F,H,O207104473(-) AGATAT/CCCAAG 1 -- int115Minor allele frequency- C:0.34EA NA EU WA 1871
    rs20593041,2
    A,C,F,H,O207075766(-) TTTTAT/GTAAAT 1 -- int112Minor allele frequency- G:0.44NA EA MN EU WA 2271
    rs10134751,2
    A,C,F,H,O207135918(-) GTCTTC/TCTATC 1 -- int124Minor allele frequency- G:0.00NA EA MN EU WA 2611
    About this table

    HapMap Linkage Disequilibrium images for ADAM23 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603710

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for ADAM23 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8745 HGNC: 202 AceView: ADAM23 Ensembl:ENSG00000114948 euGenes: HUgn8745
    ECgene: ADAM23 H-InvDB: ADAM23
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ADAM23 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADAM23:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ADAM23-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ADAM23 Antibodies for ADAM23
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ADAM23 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Drugs for ADAM23
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ADAM23

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