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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAM23 Gene

protein-coding GIFtS: 54
GCID: GC02P207272

ADAM metallopeptidase domain 23

(Previous name: a disintegrin and metalloproteinase domain 23 )

Explore 9 diseases affiliated with
ADAM23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 23¹ ²		A Disintegrin And Metalloproteinase Domain 23¹
MDC3¹ ² ³ ⁵		Disintegrin And Metalloproteinase Domain-Containing Protein 23²
Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3² ³		ADAM 23³
MDC-3² ³

External Ids:	HGNC: 202¹	Entrez Gene: 8745²	Ensembl: ENSG00000114948⁷	OMIM: 603710⁵	UniProtKB: O75077³

Export aliases for ADAM23 gene to outside databases

Previous GC identifers: GC02P205525 GC02P206032 GC02P207510 GC02P207133 GC02P207018 GC02P199158

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM23:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are

membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of

biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,

and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077

Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like

protein

Gene Wiki entry for ADAM23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAM23 gene promoter:
HOXA9 HOXA9B USF1 Brachyury E4BP4 Meis-1b CREB deltaCREB USF-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM23 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAM23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33

ADAM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM23 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P207272: view genomic region (about GC identifiers)

Start:	207,308,263 bp from pter	End:	207,485,851 bp from pter
Size:	177,589 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 23 precursor

Size: 832 amino acids; 91926 Da

Subunit: Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3

Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)

Subcellular location: Isoform Gamma: Secreted

Developmental stage: Highly expressed in the fetal brain

Secondary accessions: A2RU59

Alternative splicing: 3 isoforms: O75077-1 O75077-2 O75077-3

Explore the universe of human proteins at neXtProt for ADAM23: NX_O75077

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75077

ADAM23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003803.1

ENSEMBL proteins:

ENSP00000264377 ENSP00000363536 ENSP00000406827 ENSP00000363537

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADAM23

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005887	integral to plasma membrane	TAS	9693107

ADAM23 for ontologies About GeneDecksing

ADAM23 Antibody Products:

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	Uscn ELISAs and CLIAs for ADAM23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAM23 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR024079 MetalloPept_cat_dom

IPR001762 Blood-coag_inhib_Disintegrin

IPR006586 ADAM_Cys-rich

IPR000742 EG-like_dom

IPR001590 Peptidase_M12B

Graphical View of Domain Structure for InterPro Entry O75077

ProtoNet protein and cluster: O75077

3 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077

Domain: A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin

receptor

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077

Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like

protein

Genatlas biochemistry entry for ADAM23:

a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain

miRNA Products:		OriGene 3'-UTR Clone: ADAM23 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM23
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM23:
		hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
		SwitchGear 3'UTR luciferase reporter plasmid: ADAM23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADAM23

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		Search LifeMap BioReagents cell lines for ADAM23

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM23

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	TAS	9693107
GO:0005515	protein binding	IPI	--
GO:0008237	metallopeptidase activity	TAS	9693107
GO:0008270	zinc ion binding	IEA	--

ADAM23 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Adam23^tm1Lex for ADAM23
     2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adam23):

behavior/neurological

mortality/aging

ADAM23 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAM23

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for ADAM23 (O75077^{2, 3} ENSP00000264377⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-19336 I2D: score=1 STRING: ENSP00000309503
PRNP	P04156³	I2D: score=2
YWHAB	P31946³	I2D: score=1
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
--	ENSP00000368748⁴	STRING: ENSP00000368748

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007417	central nervous system development	TAS	9693107

ADAM23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADAM23 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAM23
1 Novoseek chemical compound relationship for ADAM23 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mdc-2	96.1	7	9693107 (4), 10433968 (2)

Search CenterWatch for drugs/clinical trials and news about ADAM23 / ADA23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAM23 gene:

NM_003812.2

Unigene Cluster for ADAM23:

ADAM metallopeptidase domain 23

Hs.591643 [show with all ESTs]

Unigene Representative Sequence: AK091800

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264377(uc002vbq.3) ENST00000374415 ENST00000444281 ENST00000374416(uc010ziv.2)

miRNA Products:		OriGene 3'-UTR Clone: ADAM23 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM23
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM23:
		hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
		SwitchGear 3'UTR luciferase reporter plasmid: ADAM23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB009672.1 AJ005580.1 AK091800.1 AK129906.1 AK296844.1 BC132763.1 BC132765.1

4 DOTS entries:

DT.438074 DT.413587 DT.436884 DT.95162339

24/62 AceView cDNA sequences (see all 62):

BI019680 BE502515 NM_003812 AA961921 BI019679 AA814554 N90403 AJ005580

AB009672 BM676690 BM714987 BX437404 F13545 BX500284 AA317222 AI692184

AW005792 AK129906 AL706283 BF691008 BM706672 BI018895 AW303311 AI377727

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAM23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATAAAAAG

About this image

ADAM23 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADAM23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM23

SOURCE GeneReport for Unigene cluster: Hs.591643

UniProtKB/Swiss-Prot: ADA23_HUMAN, O75077

Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed

prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole

SABiosciences Expression via Pathway-Focused PCR Array including ADAM23:

Breast Cancer in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM23

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADAM23 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADAM23¹	ADAM metallopeptidase domain 23	78.33(n) 81.43(a)		424099 NM_001145230.1 NP_001138702.1
lizard (Anolis carolinensis)	Reptilia	ADAM23⁶	--	72(a)	1 ↔ 1	GL343208.1(424507-464616)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12051²	Transcribed sequence with moderate similarity to protein more	77.07(n)		BX703612.1
zebrafish (Danio rerio)	Actinopterygii	BI429326.1²	--	75.28(n)		BI429326.1
fruit fly (Drosophila melanogaster)	Insecta	mmd³	metalloendopeptidase	32(a)		--

ENSEMBL Gene Tree for ADAM23 (if available)
TreeFam Gene Tree for ADAM23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAM23 gene

ADAM7² ADAM19² ADAM12² ADAM33² ADAM11² ADAM30² ADAM22² ADAM28²

ADAM29² ADAM20² ADAM9² ADAM21² ADAM15² ADAM8²

15 SIMAP similar genes for ADAM23 using alignment to 7 protein entries: ADA23_HUMAN (see all proteins):

ADAM11 ADAM22 ADAM5 ADAM29 ADAM32 ADAM21

ADAM9 ADAM7 ADAM15 ADAM12 ADAM33 ADAM19

ADAM28 ADAM18 ADAM2

ADAM23 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1448900^1,2	F	--	199156448(+)	`TCACAC/TGGGGG`	1	--	us2k¹ tfbs³		4		EA NA	148
rs10204061^1,2	C,F,A,H,	--	199156567(+)	`GTGTGC/TGCGCG`	1	--	us2k¹		7		NS	1304
rs76470768^1,2	F,	--	199156949(+)	`ATAGAA/CATGTG`	1	--	us2k¹		1		WA	118
rs200340132^1,2	C	--	199157202(-)	`GCAGGA/GATCCC`	1	--	us2k¹		0	--	--	--	--
rs75499478^1,2		--	199157250(+)	`GCCGCA/GGTCCC`	1	--	us2k¹		3		NA EA	242
rs1448903^1,2	C,F,O,H,	--	199158455(+)	`CCCCCA/GTTCAT`	1	--	int¹		14		MN NS EA NA	1924
rs58608986^1,2	F,	--	199158877(+)	`ATATTG/AATGAT`	1	--	int¹		1		WA	118
rs12618389^1,2	H	--	199159297(+)	`AGTGCA/TCAGTT`	1	--	int¹		0	--	--	--	--
rs72933203^1,2	C,F,	--	199160842(+)	`TCAGGT/AGACCT`	1	--	int¹		1		NA	120
rs1207147^1,2	C,F,A,H,	--	199161188(+)	`TGGTTA/GGTTCT`	1	--	int¹		14		NS NA WA	1706

HapMap Linkage Disequilibrium report for ADAM23 (207308263 - 207485851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM23: --

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing ADAM23:

Gastric Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM23

DNA2.0 Custom Variant and Variant Library Synthesis for ADAM23

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAM23 for disorders           About GeneDecksing

OMIM gene information: 603710    OMIM disorders: --

9 diseases for ADAM23:    About MalaCards

non-small cell lung carcinoma bruxism lung carcinoma gastric cancer

colorectal cancer asthma carcinoma cerebritis

neuronitis

Human Genome Epidemiology (HuGE) Navigator: ADAM23 (5 documents)

Export disorders for ADAM23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAM23 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ADAM23)

Utopia: connect your pdf to the dynamic
world of online information

Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)^{1, 2, 3, 9} Sagane K.... Tanaka I. (1998)
Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PubMed id 14697522)^{1, 2, 9} Sun Y.P.... Zhao S. (2004)
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD- independent mechanism. (PubMed id 10749942)^{1, 2} Cal S.... Lopez-Otin C. (2000)
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)¹ Bergen S.E....Sullivan P.F. (2012)
The expression of ADAM23 and its correlation with pro moter methylation in non-small-cell lung carcinoma. (PubMed id 21429053)¹ Hu C....Zhou J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation. (PubMed id 20851106)¹ Pan Q....Li Z. (2010)
ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis. (PubMed id 19549921)¹ Verbisck N.V....Camargo A.A. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Characterization of a specific interaction between AD AM23 and cellular prion protein. (PubMed id 19477226)¹ Costa M.D....Zanata S.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8745	HGNC: 202	AceView: ADAM23	Ensembl:ENSG00000114948	euGenes: HUgn8745
ECgene: ADAM23	H-InvDB: ADAM23

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADAM23	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADAM23	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADAM23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADAM23 gene:
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GeneCards and IP:
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ADAM23 Gene

ADAM metallopeptidase domain 23

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ADAM metallopeptidase domain 23

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