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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM22 Gene

protein-coding   GIFtS: 56
GCID: GC07P087563

ADAM metallopeptidase domain 22

(Previous name: a disintegrin and metalloproteinase domain 22 )
 Explore 3 diseases affiliated with
ADAM22 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAM22    

Aliases
for ADAM22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 221 2     Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 22 3
MDC21 2 3     ADAM 222 3
A Disintegrin And Metalloproteinase Domain 221 2     Disintegrin And Metalloproteinase Domain-Containing Protein 222
Metalloproteinase-Disintegrin ADAM22-32 3     

External Ids:    HGNC: 2011   Entrez Gene: 536162   Ensembl: ENSG000000082777   OMIM: 6037095   UniProtKB: Q9P0K13   

Export aliases for ADAM22 gene to outside databases

Previous GC identifers: GC07P086099 GC07P087161 GC07P087175 GC07P087208 GC07P087401 GC07P082173


Summaries
for ADAM22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM22:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks
metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may
function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the
peripheral nervous system. Alternative splicing results in several transcript variants.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in
regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1

Gene Wiki entry for ADAM22


Genomic Views
for ADAM22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM22 gene promoter:
         ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   AREB6   POU2F1   POU2F1a   FOXO1a   FOXO1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAM22 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21

ADAM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM22 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P087563:  view genomic region     (about GC identifiers)

Start:
 87,563,458 bp from pter      End:
 87,832,204 bp from pter
Size:
 268,747 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,895,019-87,157,811     

Proteins
for ADAM22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 22 precursor  
Size: 906 amino acids; 100433 Da
Subunit: Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts through its C-terminal region with
YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ADAM22:
3G5C (3D)    
Secondary accessions: O75075 O75076 Q9P0K2 Q9UIA1 Q9UKK2
Alternative splicing: 5 isoforms:  Q9P0K1-1   Q9P0K1-2   Q9P0K1-3   Q9P0K1-4   Q9P0K1-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Ref.2 (AAF73288) sequence is in conflict in position: 848:G->E)

Explore the universe of human proteins at neXtProt for ADAM22: NX_Q9P0K1

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P0K1

    • ADAM22 Protein expression data from MOPED and PaxDb:    About this image 
    ADAM22 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_004185.1  NP_057435.2  NP_068367.1  NP_068368.2  NP_068369.1  

    ENSEMBL proteins: 
     ENSP00000381262   ENSP00000391334   ENSP00000413899   ENSP00000381260   ENSP00000265727  
     ENSP00000381267   ENSP00000381261   ENSP00000396233   ENSP00000412085   ENSP00000315900  

    Human Recombinant Protein Products for ADAM22: 
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    Novus Biologicals ADAM22 Protein
    Novus Biologicals ADAM22 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAM22

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0016021integral to membrane NAS9693107

    ADAM22 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADAM22

    Protein Domains /
    Families
    for ADAM22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM22 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P0K1

    ProtoNet protein and cluster: Q9P0K1

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAM22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA22_HUMAN, Q9P0K1
    Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in
    regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1

         Genatlas biochemistry entry for ADAM22:
    a disintegrin and metalloprotease domain 22,membrane anchored cell surface adhesion protein,expressed in the brain

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004872receptor activity ----
    GO:0005178integrin binding NAS9693107
    GO:0005515protein binding IPI16868027
    GO:0008270zinc ion binding IEA--
         
    ADAM22 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAM22:
     Synthetic lethal with Ras  Synthetic lethal with imatinib 

         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adam22):
     behavior/neurological  growth/size  limbs/digits/tail  mortality/aging  nervous system 

    ADAM22 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Adam22tm1Sag for ADAM22
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM22 

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM22 (see all 25):
    hsa-miR-1287 hsa-miR-30c hsa-miR-148b* hsa-miR-34b* hsa-miR-30d hsa-miR-449a hsa-miR-10b* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM22 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM22 (see all 4)
    OriGene shRNA RFP: ADAM22
    OriGene siRNA: ADAM22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM22
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM22 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ADAM22 
    Sirion Biotech Customized adenovirus for potent knockdown of ADAM22

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM22 (see all 8)
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    GenScript: all cDNA clones in your preferred vector (see all 5): ADAM22 (NM_021722)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM22 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADAM22
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM22


    Pathways & Interactions
    for ADAM22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for ADAM22 (Q9P0K11, 2, 3 ENSP000002657274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI2Q9NYB92, 3MINT-51035 I2D: score=1 
    YWHAZP631041, 2, 3, ENSP000003095034EBI-1567267,EBI-347088 MINT-17974 MINT-8006332 MINT-17972 MINT-17973 MINT-8006339 I2D: score=2 STRING: ENSP00000309503
    YWHABP319461, 3, ENSP000003001614EBI-1567267,EBI-359815 I2D: score=2 STRING: ENSP00000300161
    DLG4P783523, ENSP000002938134I2D: score=2 STRING: ENSP00000293813
    LGI1O959703, ENSP000003604724I2D: score=2 STRING: ENSP00000360472
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007155cell adhesion IEA--
    GO:0007162negative regulation of cell adhesion NAS9693107
    GO:0007417central nervous system development TAS9693107
    GO:0008344adult locomotory behavior IEA--

    ADAM22 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM22
    Search CenterWatch for drugs/clinical trials and news about ADAM22 / ADA22 

    Transcripts
    for ADAM22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM22 gene (5 alternative transcripts): 
    NM_004194.3  NM_016351.4  NM_021721.3  NM_021722.4  NM_021723.3  

    Unigene Cluster for ADAM22:

    ADAM metallopeptidase domain 22
    Hs.256398  [show with all ESTs]
    Unigene Representative Sequence: NM_021723
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398204(uc003ujl.2 uc003ujn.3 uc003ujm.3 uc003ujo.3)
    ENST00000439864(uc003uji.2 uc003ujj.2) ENST00000412441 ENST00000398201(uc003ujk.2)
    ENST00000265727 ENST00000398209 ENST00000398203(uc003ujp.1) ENST00000478920
    ENST00000426930 ENST00000413139 ENST00000476330 ENST00000315984

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM22
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM22 (see all 25):
    hsa-miR-1287 hsa-miR-30c hsa-miR-148b* hsa-miR-34b* hsa-miR-30d hsa-miR-449a hsa-miR-10b* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM22 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM22 (see all 4)
    OriGene shRNA RFP: ADAM22
    OriGene siRNA: ADAM22
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM22 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM22 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ADAM22 (NM_021722)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM22

    Additional cDNA sequence: 

    AB009671.1 AF073291.2 AF155381.1 AF155382.1 AF158637.1 AK125432.1 AK291010.1 AL133090.1 
    BC036029.1 BC062433.1 BC092465.1 BC125117.1 BC125118.1 

    10 DOTS entries:

    DT.40225726  DT.100020526  DT.100750071  DT.92423837  DT.100750072  DT.101969675  DT.92423836  DT.121113513 
    DT.40225535  DT.99967531 

    24/103 AceView cDNA sequences (see all 103):

    BM695789 AA566140 AW236724 CA424050 AF155382 AA902917 AI521937 CA418996 
    NM_021722 BX280896 AW300759 AA233935 Z42567 AW237798 AA566100 BI492097 
    AA253377 AF155381 BF513463 AL601287 NM_021721 BX645477 NM_016351 AW612536 

    GeneLoc Exon Structure


    Expression
    for ADAM22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTTATT
    ADAM22 Expression
    About this image
    See ADAM22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM22

    SOURCE GeneReport for Unigene cluster: Hs.256398

    UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
    Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly
    or not at all in other tissues

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM22

    Orthologs
    for ADAM22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAM22 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAM221 ADAM metallopeptidase domain 22 79.04(n)
    80.35(a)    		   420537  NM_001145228.1  NP_001138700.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM226
    		 --
    		 77(a)
    		 1 ↔ 1
    		 6(19514946-19574920)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MDC11b2 metalloprotease/disintegrin xMDC11.2 78.43(n)    AF032383.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1739051 ADAM metallopeptidase domain 22-like 66.13(n)
    67.43(a)    		   100126805  XM_002664981.2  XP_002665027.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mmd3 metalloendopeptidase 32(a)     --


    ENSEMBL Gene Tree for ADAM22 (if available)
    TreeFam Gene Tree for ADAM22 (if available) 

    Paralogs
    for ADAM22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM22 gene
    ADAM72  ADAM192  ADAM122  ADAM232  ADAM332  ADAM112  ADAM302  ADAM282  
    ADAM292  ADAM202  ADAM92  ADAM212  ADAM152  ADAM82  
    17 SIMAP similar genes for ADAM22 using alignment to 14 protein entries:     ADA22_HUMAN (see all proteins):
    ADAM11    ADAM23    ADAM18    ADAM32    ADAM29    ADAM2
    ADAM8    ADAM21    ADAM28    ADAM17    ADAM19    ADAM9
    ADAM12    ADAM7    ADAM20    ADAM33    ADAM15

    ADAM22 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4110 NCBI SNPs in ADAM22 are shown (see all 4110)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1910109511,2
    		--87561811(+) ATCAAC/TGAGTG 5 -- us2k10--------
    rs1840969001,2
    		--87561870(+) AAAAAG/TGAACA 5 -- us2k10--------
    rs561890351,2
    		C--87562202(+) AAATAA/GATAAT 5 -- us2k10--------
    rs773956851,2
    		C--87562218(+) CTCGG-/AAAAAA 5 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1877882161,2
    		--87562276(+) TCTAAA/CTCTTA 5 -- us2k10--------
    rs1924646111,2
    		--87562466(+) TGTCTC/GTGGTC 5 -- us2k10--------
    rs1413416631,2
    		--87562483(+) ATTTGA/GGAGGC 5 -- us2k10--------
    rs1451780891,2
    		--87562484(+) TTTGGG/TAGGCT 5 -- us2k10--------
    rs1173273241,2
    		--87562529(+) GCTGCA/CGTGAG 5 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1847367301,2
    		--87562567(+) TGGGGC/TGACAG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAM22 (87563458 - 87813458 bp, first 250kb of ADAM22)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ADAM22
         4 CNVs: 64879 52302 38692 52303
         2 Indels: 100014 10798
    Human Gene Mutation Database (HGMD): ADAM22

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    Disorders / Diseases
    for ADAM22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM22 for disorders           About GeneDecksing

    OMIM gene information: 603709    OMIM disorders: --

    3 diseases for ADAM22:    About MalaCards
    ataxia    schizophrenia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ADAM22 (2 documents)

    Export disorders for ADAM22 gene to outside databases

    Publications
    for ADAM22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM22 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ADAM22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 3, 9 Sagane K.... Tanaka I. (1998)
    2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2, 3 Poindexter K....Cerretti D.P. (1999)
    3. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. (PubMed id 16385342)1, 2, 9 D'Abaco G.M.... Novak U. (2006)
    4. The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas. (PubMed id 11050470)1, 2, 9 Harada T.... Wada M. (2000)
    5. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. (PubMed id 15882968)1, 2 Zhu P.... Zhao S. (2005)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    7. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. (PubMed id 12589811)1, 2 Zhu P....Zhao S. (2003)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    9. Biological characterization of ADAM22 variants reveal s the importance of a disintegrin domain sequence in cell surface expression. (PubMed id 20156119)1, 9 Sagane K....Akaike A. (2010)
    10. Structural characterization of the ectodomain of a di sintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function. (PubMed id 19692335)2, 9 Liu H....He X. (2009)

    External Searches for ADAM22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing ADAM22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53616 HGNC: 201 AceView: ADAM22 Ensembl:ENSG00000008277 euGenes: HUgn53616
    ECgene: ADAM22 H-InvDB: ADAM22

    Other Databases showing ADAM22 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAM22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM22 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAM22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM22 gene:
    Search GeneIP for patents involving ADAM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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