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ADAM22 Gene

protein-coding   GIFtS: 62
GCID: GC07P087563

ADAM Metallopeptidase Domain 22

(Previous name: a disintegrin and metalloproteinase domain 22)
  See ADAM22-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 221 2     ADAM 222 3
A Disintegrin And Metalloproteinase Domain 221 2     And Cysteine-Rich Protein 21
Metalloproteinase-Disintegrin ADAM22-32 3     disintegrin-like1
Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 22 3     metalloproteinase-like1
MDC22 3     Disintegrin And Metalloproteinase Domain-Containing Protein 222

External Ids:    HGNC: 2011   Entrez Gene: 536162   Ensembl: ENSG000000082777   OMIM: 6037095   UniProtKB: Q9P0K13   

Export aliases for ADAM22 gene to outside databases

Previous GC identifers: GC07P086099 GC07P087161 GC07P087175 GC07P087208 GC07P087401 GC07P082173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM22 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene
lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and
may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct
myelination in the peripheral nervous system. Alternative splicing results in several transcript
variants.(provided by RefSeq, Dec 2010)

GeneCards Summary for ADAM22 Gene:
ADAM22 (ADAM metallopeptidase domain 22) is a protein-coding gene. Diseases associated with ADAM22 include limbic encephalitis. GO annotations related to this gene include integrin binding and metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor
for LGI1

Gene Wiki entry for ADAM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM22 gene promoter:
         ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   AREB6   POU2F1   POU2F1a   FOXO1a   FOXO1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAM22 promoter sequence
   Search Chromatin IP Primers for ADAM22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21

ADAM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM22 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P087563:  view genomic region     (about GC identifiers)

Start:
87,563,458 bp from pter      End:
87,832,204 bp from pter
Size:
268,747 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,894,883-87,163,561     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 22 precursor  
Size: 906 amino acids; 100433 Da
Subunit: Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts through its C-terminal region with
YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta
1 PDB 3D structure from and Proteopedia for ADAM22:
3G5C (3D)    
Secondary accessions: O75075 O75076 Q9P0K2 Q9UIA1 Q9UKK2
Alternative splicing: 5 isoforms:  Q9P0K1-1   Q9P0K1-2   Q9P0K1-3   Q9P0K1-4   Q9P0K1-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Ref.2 (AAF73288) sequence is in conflict in position: 848:G->E)

Explore the universe of human proteins at neXtProt for ADAM22: NX_Q9P0K1

Explore proteomics data for ADAM22 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn175, Asn519, Asn634, Asn675
  • Modification sites at PhosphoSitePlus

  • See ADAM22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_004185.1  NP_057435.2  NP_068367.1  NP_068368.2  NP_068369.1  

    ENSEMBL proteins: 
     ENSP00000381262   ENSP00000391334   ENSP00000413899   ENSP00000381260   ENSP00000265727  
     ENSP00000381267   ENSP00000381261   ENSP00000396233   ENSP00000412085   ENSP00000315900  

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    Novus Biologicals ADAM22 Protein
    Novus Biologicals ADAM22 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ADAM22

     
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    antibodies-online proteins for ADAM22 (4 products) 

     
    antibodies-online peptides for ADAM22

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    antibodies-online antibodies for ADAM22 (57 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM22
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry Q9P0K1

    ProtoNet protein and cluster: Q9P0K1

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Find genes that share domains with ADAM22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA22_HUMAN, Q9P0K1
    Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
    Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor
    for LGI1

         Genatlas biochemistry entry for ADAM22:
    a disintegrin and metalloprotease domain 22,membrane anchored cell surface adhesion protein,expressed in the brain

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding NAS9693107
    GO:0005515protein binding IPI12589811
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAM22           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAM22:
     Synthetic lethal with Ras  Synthetic lethal with imatinib 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam22):
     behavior/neurological  growth/size/body  limbs/digits/tail  mortality/aging  nervous system 

    Find genes that share phenotypes with ADAM22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adam22tm1Sag for ADAM22

       genOway: Develop your customized and physiologically relevant rodent model for ADAM22

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAM22 (see all 25):
    hsa-miR-1287 hsa-miR-30c hsa-miR-148b* hsa-miR-34b* hsa-miR-30d hsa-miR-449a hsa-miR-10b* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidADAM22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADAM22
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM22

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    GenScript: all cDNA clones in your preferred vector (see all 5): ADAM22 (NM_021722)
    Sino Biological Human cDNA Clone for ADAM22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM22

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA22_HUMAN, Q9P0K1: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0016021integral component of membrane NAS9693107

    Find genes that share ontologies with ADAM22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM22 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch Signaling Pathway (sino)
    Notch Signaling Pathway


    1 Sino Biological Pathway for ADAM22
        Notch Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM22
    Interactions:

        GeneGlobe Interaction Network for ADAM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ADAM22 (Q9P0K11, 2, 3 ENSP000002657274) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI2Q9NYB92, 3MINT-51035 I2D: score=1 
    YWHAZP631041, 2, 3, ENSP000003095034EBI-1567267,EBI-347088 MINT-17974 MINT-8006332 MINT-17972 MINT-17973 MINT-8006339 I2D: score=2 STRING: ENSP00000309503
    YWHABP319461, 3, ENSP000003001614EBI-1567267,EBI-359815 I2D: score=2 STRING: ENSP00000300161
    LGI1O959703, ENSP000003604724I2D: score=2 STRING: ENSP00000360472
    YWHAQP273481, ENSP000002380814EBI-1567267,EBI-359854 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007155cell adhesion IEA--
    GO:0007162negative regulation of cell adhesion NAS9693107
    GO:0007417central nervous system development TAS9693107
    GO:0008344adult locomotory behavior IEA--

    Find genes that share ontologies with ADAM22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM22 (ADA22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAM22 gene (5 alternative transcripts): 
    NM_004194.3  NM_016351.4  NM_021721.3  NM_021722.4  NM_021723.3  

    Unigene Cluster for ADAM22:

    ADAM metallopeptidase domain 22
    Hs.256398  [show with all ESTs]
    Unigene Representative Sequence: NM_021723
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398204(uc003ujl.2 uc003ujn.3 uc003ujm.3 uc003ujo.3)
    ENST00000439864(uc003uji.2 uc003ujj.2) ENST00000412441 ENST00000398201(uc003ujk.2)
    ENST00000265727 ENST00000398209 ENST00000398203(uc003ujp.1) ENST00000478920
    ENST00000426930 ENST00000413139 ENST00000476330 ENST00000315984
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAM22 (see all 25):
    hsa-miR-1287 hsa-miR-30c hsa-miR-148b* hsa-miR-34b* hsa-miR-30d hsa-miR-449a hsa-miR-10b* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidADAM22 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM22
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM22
      QuantiFast Probe-based Assays in human, mouse, rat ADAM22

    Additional mRNA sequence: 

    AB009671.1 AF073291.2 AF155381.1 AF155382.1 AF158637.1 AK125432.1 AK291010.1 AL133090.1 
    BC036029.1 BC062433.1 BC092465.1 BC125117.1 BC125118.1 

    10 DOTS entries:

    DT.40225726  DT.100020526  DT.100750071  DT.92423837  DT.100750072  DT.101969675  DT.92423836  DT.121113513 
    DT.40225535  DT.99967531 

    Selected AceView cDNA sequences (see all 103):

    AA566100 NM_004194 BX645477 AL601287 AW300759 CA424050 NM_021722 BF513463 
    AF155381 BX280896 AA253377 AW236724 Z42567 AA233935 CA418996 AF073291 
    AA902917 AW612536 AL133090 NM_021721 AI521937 AF155382 AW237798 BI492097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTATT
    ADAM22 Expression
    About this image


    ADAM22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
    ADAM22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256398

    UniProtKB/Swiss-Prot: ADA22_HUMAN, Q9P0K1
    Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected
    slightly or not at all in other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAM22 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam221 , 5 a disintegrin and metallopeptidase domain 221, 5 88.36(n)1
    91.71(a)1
      5 (3.39 cM)5
    114961  NM_001098225.11  NP_001091695.11 
     80723525 
    chicken
    (Gallus gallus)
    Aves ADAM221 ADAM metallopeptidase domain 22 79.04(n)
    80.35(a)
      420537  NM_001145228.1  NP_001138700.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM226
    ADAM metallopeptidase domain 22
    73(a)
    1 ↔ 1
    6(19428953-19574920)
    African clawed frog
    (Xenopus laevis)
    Amphibia MDC11b2 metalloprotease/disintegrin xMDC11.2 78.43(n)    AF032383.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739051 ADAM metallopeptidase domain 22-like 66.21(n)
    67.78(a)
      100126805  XM_002664981.3  XP_002665027.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta mmd3 metalloendopeptidase 32(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-716
    Protein UNC-71 (unc-71) mRNA, complete cds
    21(a)
    1 → many
    III(12881041-12891738) WBGene00006804


    ENSEMBL Gene Tree for ADAM22 (if available)
    TreeFam Gene Tree for ADAM22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM22 gene
    ADAM322  ADAM232  ADAM182  ADAM112  ADAM22  ADAMDEC12  
    16 SIMAP similar genes for ADAM22 using alignment to 14 protein entries:     ADA22_HUMAN (see all proteins):
    ADAM11    ADAM23    ADAM32    ADAM29    ADAM2    ADAM8
    ADAM21    ADAM28    ADAM17    ADAM19    ADAM9    ADAM12
    ADAM7    ADAM15    ADAM20    ADAM33

    Find genes that share paralogs with ADAM22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM22 (see all 5012)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910109511,2
    --87561811(+) ATCAAC/TGAGTG 5 -- us2k10--------
    rs1840969001,2
    --87561870(+) AAAAAG/TGAACA 5 -- us2k10--------
    rs561890351,2
    C--87562202(+) AAATAA/GATAAT 5 -- us2k10--------
    rs773956851,2
    C--87562218(+) CTCGG-/AAAAAA 5 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1877882161,2
    --87562276(+) TCTAAA/CTCTTA 5 -- us2k10--------
    rs1924646111,2
    --87562466(+) TGTCTC/GTGGTC 5 -- us2k10--------
    rs1413416631,2
    --87562483(+) ATTTGA/GGAGGC 5 -- us2k10--------
    rs1451780891,2
    --87562484(+) TTTGGG/TAGGCT 5 -- us2k10--------
    rs1173273241,2
    F--87562529(+) GCTGCA/CGTGAG 5 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1847367301,2
    --87562567(+) TGGGGC/TGACAG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAM22 (87563458 - 87813458 bp, first 250kb of ADAM22)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAM22 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421625CNV Deletion20811451
    esv2674844CNV Deletion23128226
    esv2486343CNV Insertion19546169
    nsv437021CNV Loss16327808
    nsv529001CNV Loss19592680
    nsv888696CNV Loss21882294
    esv29888CNV Loss19812545
    nsv514430CNV Loss21397061
    nsv517676CNV Loss19592680
    nsv525073CNV Gain19592680

    Human Gene Mutation Database (HGMD): ADAM22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM22
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603709    OMIM disorders: --

    1 disease for ADAM22:    
    About MalaCards
    limbic encephalitis


    Find genes that share disorders with ADAM22           About GenesLikeMe

    Genetic Association Database (GAD): ADAM22
    Human Genome Epidemiology (HuGE) Navigator: ADAM22 (2 documents)

    Export disorders for ADAM22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM22 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ADAM22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 3, 9 Sagane K.... Tanaka I. (Biochem. J. 1998)
    2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2, 3 Poindexter K.... Cerretti D.P. (Gene 1999)
    3. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. (PubMed id 16385342)1, 2, 9 D'Abaco G.M.... Novak U. (Neurosurgery 2006)
    4. The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas. (PubMed id 11050470)1, 2, 9 Harada T.... Wada M. (Jpn. J. Cancer Res. 2000)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    7. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. (PubMed id 15882968)1, 2 Zhu P.... Zhao S. (Biochem. Biophys. Res. Commun. 2005)
    8. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    9. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. (PubMed id 12589811)1, 2 Zhu P....Zhao S. (Biochem. Biophys. Res. Commun. 2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53616 HGNC: 201 AceView: ADAM22 Ensembl:ENSG00000008277 euGenes: HUgn53616
    ECgene: ADAM22 H-InvDB: ADAM22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM22 gene:
    Search GeneIP for patents involving ADAM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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