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Aliases for ADAM22 Gene

Aliases for ADAM22 Gene

  • ADAM Metallopeptidase Domain 22 2 3
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 2 3 4
  • A Disintegrin And Metalloproteinase Domain 22 2 3
  • Metalloproteinase-Disintegrin ADAM22-3 3 4
  • ADAM 22 3 4
  • MDC2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 22 3
  • And Cysteine-Rich Protein 2 2
  • Metalloproteinase-Like 2
  • Disintegrin-Like 2

External Ids for ADAM22 Gene

Previous GeneCards Identifiers for ADAM22 Gene

  • GC07P086099
  • GC07P087161
  • GC07P087175
  • GC07P087208
  • GC07P087401
  • GC07P087563
  • GC07P082173

Summaries for ADAM22 Gene

Entrez Gene Summary for ADAM22 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for ADAM22 Gene

ADAM22 (ADAM Metallopeptidase Domain 22) is a Protein Coding gene. Diseases associated with ADAM22 include limbic encephalitis. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include metalloendopeptidase activity and integrin binding. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot for ADAM22 Gene

  • Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Gene Wiki entry for ADAM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM22 Gene

Genomics for ADAM22 Gene

Regulatory Elements for ADAM22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAM22 Gene

87,934,143 bp from pter
88,202,889 bp from pter
268,747 bases
Plus strand

Genomic View for ADAM22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM22 Gene

Proteins for ADAM22 Gene

  • Protein details for ADAM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • O75075
    • O75076
    • Q9P0K2
    • Q9UIA1
    • Q9UKK2

    Protein attributes for ADAM22 Gene

    906 amino acids
    Molecular mass:
    100433 Da
    Quaternary structure:
    • Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts with KCNA2, DLG2 and DLG4 (By similarity). Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.

    Three dimensional structures from OCA and Proteopedia for ADAM22 Gene

    Alternative splice isoforms for ADAM22 Gene


neXtProt entry for ADAM22 Gene

Proteomics data for ADAM22 Gene at MOPED

Post-translational modifications for ADAM22 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn175, Asn519, Asn634, and Asn675
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADAM22 Gene

Domains for ADAM22 Gene

Gene Families for ADAM22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 disintegrin domain.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM22: view

Function for ADAM22 Gene

Molecular function for ADAM22 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 22,membrane anchored cell surface adhesion protein,expressed in the brain
UniProtKB/Swiss-Prot Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Gene Ontology (GO) - Molecular Function for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding NAS 9693107
GO:0005515 protein binding IPI 12589811
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM22: view
genes like me logo Genes that share phenotypes with ADAM22: view

Animal Models for ADAM22 Gene

MGI Knock Outs for ADAM22:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM22 Gene

Localization for ADAM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM22 Gene

Membrane; Single-pass type I membrane protein. Cell projection, axon.

Subcellular locations from

Jensen Localization Image for ADAM22 Gene COMPARTMENTS Subcellular localization image for ADAM22 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 9693107
GO:0030424 axon ISS --
genes like me logo Genes that share ontologies with ADAM22: view

Pathways for ADAM22 Gene

SuperPathways for ADAM22 Gene

Superpath Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAM22: view

Pathways by source for ADAM22 Gene

1 Sino Biological pathway for ADAM22 Gene

Gene Ontology (GO) - Biological Process for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion NAS 9693107
GO:0007417 central nervous system development TAS 9693107
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with ADAM22: view

Transcripts for ADAM22 Gene

Unigene Clusters for ADAM22 Gene

ADAM metallopeptidase domain 22:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM22 Gene

No ASD Table

Relevant External Links for ADAM22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM22 Gene

mRNA expression in normal human tissues for ADAM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM22 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (10.0) and Brain - Cerebellum (8.1).

Protein differential expression in normal tissues for ADAM22 Gene

This gene is overexpressed in Frontal cortex (53.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM22 Gene

SOURCE GeneReport for Unigene cluster for ADAM22 Gene Hs.256398

mRNA Expression by UniProt/SwissProt for ADAM22 Gene

Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
genes like me logo Genes that share expressions with ADAM22: view

Expression partners for ADAM22 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for ADAM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAM22 35
  • 93.47 (n)
  • 95.8 (a)
ADAM22 36
  • 94 (a)
(Canis familiaris)
Mammalia ADAM22 35
  • 92.58 (n)
  • 94.66 (a)
ADAM22 36
  • 92 (a)
(Mus musculus)
Mammalia Adam22 35
  • 88.36 (n)
  • 91.71 (a)
Adam22 16
Adam22 36
  • 92 (a)
(Pan troglodytes)
Mammalia ADAM22 35
  • 99.67 (n)
  • 99.45 (a)
ADAM22 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ADAM22 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ADAM22 36
  • 82 (a)
(Gallus gallus)
Aves ADAM22 35
  • 79.04 (n)
  • 80.35 (a)
ADAM22 36
  • 78 (a)
(Anolis carolinensis)
Reptilia ADAM22 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adam22 35
  • 72.55 (n)
  • 74.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MDC11b 35
(Danio rerio)
Actinopterygii zgc:173905 35
  • 66.21 (n)
  • 67.78 (a)
adam22 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 32 (a)
mmd 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea unc-71 36
  • 21 (a)
Species with no ortholog for ADAM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM22 Gene

Gene Tree for ADAM22 (if available)
Gene Tree for ADAM22 (if available)

Paralogs for ADAM22 Gene

Paralogs for ADAM22 Gene

genes like me logo Genes that share paralogs with ADAM22: view

Variants for ADAM22 Gene

Sequence variations from dbSNP and Humsavar for ADAM22 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2299206 -- 88,173,698(+) TAAAT(G/T)AGGTT intron-variant
rs2299205 -- 88,165,392(+) CTCCC(C/T)TCTTC intron-variant
rs2299204 -- 88,165,137(+) CTCTA(C/T)TCAAG intron-variant
rs2299203 -- 88,164,537(+) TAGTT(A/G)GGAGT intron-variant
rs2299202 -- 88,135,444(+) ACTAG(A/C)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM22 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv888696 CNV Loss 21882294
nsv525073 CNV Gain 19592680
nsv529001 CNV Loss 19592680
nsv517676 CNV Loss 19592680
nsv437021 CNV Loss 16327808
esv2674844 CNV Deletion 23128226
esv29888 CNV Loss 19812545
esv2421625 CNV Deletion 20811451
nsv442056 CNV CNV 18776908
nsv514430 CNV Loss 21397061
esv2486343 CNV Insertion 19546169

Relevant External Links for ADAM22 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM22 Gene

Disorders for ADAM22 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADAM22 Gene in MalaCards »

(1) Disease for ADAM22 Gene

Relevant External Links for ADAM22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADAM22: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAM22 Gene

Publications for ADAM22 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K. … Tanaka I. (Biochem. J. 1998) 2 3 4 23
  2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PMID: 10524237) Poindexter K. … Cerretti D.P. (Gene 1999) 2 3 4
  3. The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas. (PMID: 11050470) Harada T. … Wada M. (Jpn. J. Cancer Res. 2000) 3 4 23
  4. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. (PMID: 16385342) D'Abaco G.M. … Novak U. (Neurosurgery 2006) 3 4 23
  5. Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy. (PMID: 17681454) Chabrol E. … Baulac S. (Epilepsy Res. 2007) 3 23

Products for ADAM22 Gene

Sources for ADAM22 Gene

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