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Aliases for ADAM22 Gene

Aliases for ADAM22 Gene

  • ADAM Metallopeptidase Domain 22 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 2 3 4
  • A Disintegrin And Metalloproteinase Domain 22 2 3
  • Metalloproteinase-Disintegrin ADAM22-3 3 4
  • ADAM 22 3 4
  • MDC2 3 4
  • And Cysteine-Rich Protein 2 2
  • Metalloproteinase-Like 2
  • Disintegrin-Like 2

External Ids for ADAM22 Gene

Previous GeneCards Identifiers for ADAM22 Gene

  • GC07P086099
  • GC07P087161
  • GC07P087175
  • GC07P087208
  • GC07P087401
  • GC07P087563
  • GC07P082173

Summaries for ADAM22 Gene

Entrez Gene Summary for ADAM22 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for ADAM22 Gene

ADAM22 (ADAM Metallopeptidase Domain 22) is a Protein Coding gene. Diseases associated with ADAM22 include limbic encephalitis. Among its related pathways are Notch Signaling Pathway (sino) and Developmental Biology. GO annotations related to this gene include metalloendopeptidase activity and integrin binding. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot for ADAM22 Gene

  • Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Gene Wiki entry for ADAM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM22 Gene

Genomics for ADAM22 Gene

Regulatory Elements for ADAM22 Gene

Enhancers for ADAM22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAM22 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM22 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM22 Gene

Chromosome:
7
Start:
87,934,143 bp from pter
End:
88,202,889 bp from pter
Size:
268,747 bases
Orientation:
Plus strand

Genomic View for ADAM22 Gene

Genes around ADAM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM22 Gene

Proteins for ADAM22 Gene

  • Protein details for ADAM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0K1-ADA22_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 22
    Protein Accession:
    Q9P0K1
    Secondary Accessions:
    • O75075
    • O75076
    • Q9P0K2
    • Q9UIA1
    • Q9UKK2

    Protein attributes for ADAM22 Gene

    Size:
    906 amino acids
    Molecular mass:
    100433 Da
    Quaternary structure:
    • Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts with KCNA2, DLG2 and DLG4 (By similarity). Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.

    Three dimensional structures from OCA and Proteopedia for ADAM22 Gene

    Alternative splice isoforms for ADAM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM22 Gene

Proteomics data for ADAM22 Gene at MOPED

Post-translational modifications for ADAM22 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 175, Asn 519, Asn 634, and Asn 675
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADAM22 Gene

Domains & Families for ADAM22 Gene

Gene Families for ADAM22 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0K1

UniProtKB/Swiss-Prot:

ADA22_HUMAN :
  • Contains 1 disintegrin domain.
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM22: view

Function for ADAM22 Gene

Molecular function for ADAM22 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 22,membrane anchored cell surface adhesion protein,expressed in the brain
UniProtKB/Swiss-Prot Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
genes like me logo Genes that share phenotypes with ADAM22: view

Animal Models for ADAM22 Gene

MGI Knock Outs for ADAM22:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM22 Gene

Localization for ADAM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM22 Gene

Membrane; Single-pass type I membrane protein. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM22 Gene COMPARTMENTS Subcellular localization image for ADAM22 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ADAM22: view

Pathways & Interactions for ADAM22 Gene

genes like me logo Genes that share pathways with ADAM22: view

Pathways by source for ADAM22 Gene

1 Sino Biological pathway for ADAM22 Gene
2 Reactome pathways for ADAM22 Gene

Gene Ontology (GO) - Biological Process for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion NAS 9693107
GO:0007417 central nervous system development TAS 9693107
GO:0022011 myelination in peripheral nervous system IEA --
GO:0042063 gliogenesis IEA --
genes like me logo Genes that share ontologies with ADAM22: view

No data available for SIGNOR curated interactions for ADAM22 Gene

Drugs & Compounds for ADAM22 Gene

No Compound Related Data Available

Transcripts for ADAM22 Gene

Unigene Clusters for ADAM22 Gene

ADAM metallopeptidase domain 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM22 Gene

No ASD Table

Relevant External Links for ADAM22 Gene

GeneLoc Exon Structure for
ADAM22
ECgene alternative splicing isoforms for
ADAM22

Expression for ADAM22 Gene

mRNA expression in normal human tissues for ADAM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM22 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.0) and Brain - Cerebellum (x8.1).

Protein differential expression in normal tissues from HIPED for ADAM22 Gene

This gene is overexpressed in Frontal cortex (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM22 Gene



SOURCE GeneReport for Unigene cluster for ADAM22 Gene Hs.256398

mRNA Expression by UniProt/SwissProt for ADAM22 Gene

Q9P0K1-ADA22_HUMAN
Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
genes like me logo Genes that share expression patterns with ADAM22: view

Protein tissue co-expression partners for ADAM22 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADAM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM22 35
  • 93.47 (n)
  • 95.8 (a)
ADAM22 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM22 35
  • 92.58 (n)
  • 94.66 (a)
ADAM22 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam22 35
  • 88.36 (n)
  • 91.71 (a)
Adam22 16
Adam22 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM22 35
  • 99.67 (n)
  • 99.45 (a)
ADAM22 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM22 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM22 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM22 35
  • 79.04 (n)
  • 80.35 (a)
ADAM22 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM22 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam22 35
  • 72.55 (n)
  • 74.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MDC11b 35
zebrafish
(Danio rerio)
Actinopterygii zgc:173905 35
  • 66.21 (n)
  • 67.78 (a)
adam22 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 32 (a)
mmd 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-71 36
  • 21 (a)
OneToMany
Species with no ortholog for ADAM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM22 Gene

ENSEMBL:
Gene Tree for ADAM22 (if available)
TreeFam:
Gene Tree for ADAM22 (if available)

Paralogs for ADAM22 Gene

Paralogs for ADAM22 Gene

genes like me logo Genes that share paralogs with ADAM22: view

Variants for ADAM22 Gene

Sequence variations from dbSNP and Humsavar for ADAM22 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2279542 - 87,935,182(+) TGGCC(C/G/T)GCAGG reference, missense
rs4728730 - 88,075,657(+) AGAGA(C/T)ACATT reference, missense
rs17255978 - 88,125,600(+) AGCAA(A/G)TAAAC reference, missense
rs917205 -- 88,088,447(-) GTATC(C/T)CTTTT intron-variant
rs956491 -- 87,981,523(+) ATGAA(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM22 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv888696 CNV Loss 21882294
nsv525073 CNV Gain 19592680
nsv529001 CNV Loss 19592680
nsv517676 CNV Loss 19592680
nsv437021 CNV Loss 16327808
esv2674844 CNV Deletion 23128226
esv29888 CNV Loss 19812545
esv2421625 CNV Deletion 20811451
nsv442056 CNV CNV 18776908
nsv514430 CNV Loss 21397061
esv2486343 CNV Insertion 19546169

Variation tolerance for ADAM22 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM22 Gene

HapMap Linkage Disequilibrium report
ADAM22
Human Gene Mutation Database (HGMD)
ADAM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM22 Gene

Disorders for ADAM22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM22 Gene - From: GeneCards

Disorder Aliases PubMed IDs
limbic encephalitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAM22

Genetic Association Database (GAD)
ADAM22
Human Genome Epidemiology (HuGE) Navigator
ADAM22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM22
genes like me logo Genes that share disorders with ADAM22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM22 Gene

Publications for ADAM22 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K. … Tanaka I. (Biochem. J. 1998) 2 3 4 23 67
  2. Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression. (PMID: 20156119) Sagane K. … Akaike A. (J. Recept. Signal Transduct. Res. 2010) 3 23
  3. Expression, purification and insights into structure and folding of the ADAM22 pro domain. (PMID: 18593599) SA … Wewer U.M. (Protein Expr. Purif. 2008) 3 23
  4. Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy. (PMID: 17681454) Chabrol E. … Baulac S. (Epilepsy Res. 2007) 3 23
  5. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. (PMID: 16385342) D'Abaco G.M. … Novak U. (Neurosurgery 2006) 3 23

Products for ADAM22 Gene

Sources for ADAM22 Gene

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