Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAM21 Gene

protein-coding GIFtS: 45
GCID: GC14P070924

ADAM metallopeptidase domain 21

(Previous name: a disintegrin and metalloproteinase domain 21 )

Search for ADAM21
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 21¹ ²		ADAM Metallopeptidase Domain 21, Preproprotein²
ADAM31¹ ²		Disintegrin And Metalloproteinase Domain-Containing Protein 21²
A Disintegrin And Metalloproteinase Domain 21¹ ²		EC 3.4.24.-³
ADAM 21² ³

External Ids:	HGNC: 200¹	Entrez Gene: 8747²	Ensembl: ENSG00000139985⁷	OMIM: 603713⁵	UniProtKB: Q9UKJ8³

Export aliases for ADAM21 gene to outside databases

Previous GC identifers: GC14P068429 GC14P064720 GC14P068914 GC14P068688 GC14P069993

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM21:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are

membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of

biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,

and neurogenesis. The expression of this gene expression is testis-specific. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8

Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions

associated with establishing and maintaining gradients of ions or nutrients

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAM21 gene promoter:
Pbx1a C/EBPalpha E47 RORalpha2 CHOP-10 POU2F1 POU2F1a Hand1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM21 promoter sequence

Search SABiosciences Chromatin IP Primers for ADAM21

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.1

ADAM21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM21 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P070924: view genomic region (about GC identifiers)

Start:	70,924,217 bp from pter	End:	70,926,622 bp from pter
Size:	2,406 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 21 precursor

Size: 722 amino acids; 80834 Da

Cofactor: Binds 1 zinc ion per subunit (Potential)

Subcellular location: Membrane; Single-pass type I membrane protein

Miscellaneous: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human

Secondary accessions: O43507 Q2VPC6 Q32MR0

Explore the universe of human proteins at neXtProt for ADAM21: NX_Q9UKJ8

Post-translational modifications:

Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKJ8

ADAM21 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003804.2

ENSEMBL proteins:

ENSP00000267499

Human Recombinant Protein Products for ADAM21:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ADAM21
	GenScript Custom Purified and Recombinant Proteins Services for ADAM21
	Novus Biologicals ADAM21 Protein Novus Biologicals ADAM21 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADAM21

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

ADAM21 for ontologies About GeneDecksing

ADAM21 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM21
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ADAM21
	GenScript Custom Superior Antibodies Services for ADAM21
	Novus Biologicals ADAM21 Antibodies
	Abcam antibodies for ADAM21
	Uscn Antibodies for ADAM21
	Search ThermoFisher Antibodies for ADAM21

Assay Products for ADAM21:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAM21
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADAM21

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAM21 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR018358 Disintegrin_CS

IPR024079 MetalloPept_cat_dom

IPR001762 Blood-coag_inhib_Disintegrin

IPR006586 ADAM_Cys-rich

IPR001590 Peptidase_M12B

Graphical View of Domain Structure for InterPro Entry Q9UKJ8

ProtoNet protein and cluster: Q9UKJ8

3 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8

Domain: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin

receptor and thus could mediate sperm/egg binding

Domain: The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADA21_HUMAN, Q9UKJ8

Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions

associated with establishing and maintaining gradients of ions or nutrients

Genatlas biochemistry entry for ADAM21:

a disintegrin and metalloprotease (active) domain 21,membrane anchored cell surface adhesion protein,testis specific

with similarity to fertilin-alpha

Enzyme Number (IUBMB): EC 3.4.24.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008237	metallopeptidase activity	TAS	9469942
GO:0008270	zinc ion binding	IEA	--

ADAM21 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Adam21):

normal

ADAM21 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adam21^tm1Lex for ADAM21

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM21

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM21
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADAM21
		SwitchGear 3'UTR luciferase reporter plasmid: ADAM21 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM21 (see all 4) OriGene shRNA RFP: ADAM21 OriGene siRNA: ADAM21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM21
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM21

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADAM21
			Sirion Biotech Customized adenovirus for overexpression of ADAM21 Sirion Biotech Customized adenovirus for potent knockdown of ADAM21

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADAM21 (NM_003813)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADAM21
		Search LifeMap BioReagents cell lines for ADAM21
		Sirion Biotech Customized stable knockdown cell line services for ADAM21 Sirion Biotech Customized inducible knockdown cell line services for ADAM21 Sirion Biotech Customized stable overexpressing cell line services for ADAM21 Sirion Biotech Customized inducible overexpressing cell line services for ADAM21

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM21

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAM21

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007338	single fertilization	TAS	9469942

ADAM21 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAM21
Search CenterWatch for drugs/clinical trials and news about ADAM21 / ADA21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAM21 gene:

NM_003813.3

Unigene Cluster for ADAM21:

ADAM metallopeptidase domain 21

Hs.178748 [show with all ESTs]

Unigene Representative Sequence: NM_003813

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000267499(uc021rvq.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM21
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADAM21
		SwitchGear 3'UTR luciferase reporter plasmid: ADAM21 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM21 (see all 4) OriGene shRNA RFP: ADAM21 OriGene siRNA: ADAM21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM21
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM21

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADAM21 (NM_003813)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM21

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAM21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM21

Additional cDNA sequence:

AF029900.1 BC109024.1 BC109025.1

1 DOTS entry:

DT.103709

4 AceView cDNA sequences:

BX089075 NM_003813 BU619464 AF029900

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAM21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTATCTA

About this image

ADAM21 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADAM21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM21

SOURCE GeneReport for Unigene cluster: Hs.178748

SABiosciences Custom PCR Arrays for ADAM21

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAM21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM21

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADAM21 gene from 2/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- --	Uncharacterized protein	39(a) 36(a)	1 ↔ many possible ortholog	5(29718591-29720786) 1(200970627-200985987)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 6)	--	42(a) 42(a) (see all 6)	many ↔ many many ↔ many (see all 6)	GL343318.1(1387820-1389757) GL343318.1(1397144-1399132)

ENSEMBL Gene Tree for ADAM21 (if available)
TreeFam Gene Tree for ADAM21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAM21 gene

ADAM7² ADAM19² ADAM12² ADAM23² ADAM33² ADAM11² ADAM30² ADAM22²

ADAM28² ADAM29² ADAM20² ADAM9² ADAM15² ADAM8²

15 SIMAP similar genes for ADAM21 using alignment to 1 protein entry: ADA21_HUMAN:

ADAM20 ADAM29 ADAM30 ADAM9 ADAM23 ADAM19

ADAM32 ADAM12 ADAM18 ADAM22 ADAM2 ADAM7

ADAM33 ADAM28 ADAM8

ADAM21 for paralogs About GeneDecksing

5/7 Pseudogenes.org Pseudogenes for ADAM21 (see all 7)
PGOHUM00000239927 PGOHUM00000257964 PGOHUM00000247914 PGOHUM00000246615 PGOHUM00000246632

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138015902^1,2		--	70916893(+)	`AGTTTC/TCCCAT`	1	--	us2k¹		0	--	--	--	--
rs184058722^1,2		--	70916902(+)	`ATGACA/TTTTGG`	1	--	us2k¹		0	--	--	--	--
rs188830761^1,2		--	70916913(+)	`GTGGAA/GAAGGA`	1	--	us2k¹		0	--	--	--	--
rs72735753^1,2	C	--	70916922(+)	`GATGGT/GTATTT`	1	--	us2k¹		3		CSA WA NA	239
rs142699316^1,2		--	70916947(+)	`GTCTCG/TCCAGA`	1	--	us2k¹		0	--	--	--	--
rs146024581^1,2		--	70917003(+)	`GTCTTC/TTTGTT`	1	--	us2k¹		0	--	--	--	--
rs140035025^1,2		--	70917035(+)	`TGTTAC/TAGGCT`	1	--	us2k¹		0	--	--	--	--
rs73291961^1,2	C	--	70917089(+)	`ACCATG/ATTATT`	1	--	us2k¹		2		WA	120
rs149341086^1,2		--	70917287(+)	`GTCTCA/TTCAGT`	1	--	us2k¹		0	--	--	--	--
rs181632616^1,2		--	70917321(+)	`AAACAA/TTGTTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADAM21 (70924217 - 70926622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM21: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM21

DNA2.0 Custom Variant and Variant Library Synthesis for ADAM21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAM21 for disorders About MalaCards

ADAM21 for disorders About GeneDecksing

OMIM gene information: 603713 OMIM disorders: --

Export disorders for ADAM21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAM21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM21)

Utopia: connect your pdf to the dynamic
world of online information

ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942)^{1, 2, 3} Hooft van Huijsduijnen R. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)^{1, 2} Poindexter K....Cerretti D.P. (1999)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8747	HGNC: 200	AceView: ADAM21	Ensembl:ENSG00000139985	euGenes: HUgn8747
ECgene: ADAM21	H-InvDB: ADAM21

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADAM21	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAM21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADAM21 gene:
Search GeneIP for patents involving ADAM21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM21
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ADAM21
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM21		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM21
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ADAM21		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM21
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADAM21		OriGene Custom Protein Services for ADAM21
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM21
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM21
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM21
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM21
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM21
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM21

	GenScript Custom Purified and Recombinant Proteins Services for ADAM21		GenScript cDNA clones with any tag delivered in your preferred vector for ADAM21
	GenScript Custom Assay Services for ADAM21		GenScript Custom Superior Antibodies Services for ADAM21
	GenScript Custom overexpressing Cell Line Services for ADAM21		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ADAM21 promoter
	Search Chromatin IP Primers for ADAM21
	RT² qPCR Primer Assay in human, mouse, rat ADAM21
	Search GNC Networks for ADAM21
	SABiosciences Custom PCR Arrays for ADAM21

Search Tocris compounds for ADAM21

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADAM21 antibodies
	ADAM21 proteins
	ADAM21 lysates

	Antibodies for ADAM21
	See all of Abcam's Antibodies, Kits and Proteins for ADAM21
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ADAM21 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ADAM21

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM21

	SwitchGear 3'UTR luciferase reporter plasmids for ADAM21
	SwitchGear Promoter luciferase reporter plasmids for ADAM21

Search ThermoFisher Antibodies for ADAM21

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM21

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM21

Sirion Biotech Customized:

	stable knockdown cell line services for ADAM21
	inducible knockdown cell line services for ADAM21
	design and validation of potent shRNA sequences against ADAM21
	adenovirus for potent knockdown of ADAM21
	adenovirus for overexpression of ADAM21
	stable overexpressing cell line services for ADAM21
	inducible overexpressing cell line services for ADAM21

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADAM21 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ADAM21 Gene

ADAM metallopeptidase domain 21

Aliases
for ADAM21 gene

Summaries
for ADAM21 gene

Genomic Views
for ADAM21 gene

Proteins
for ADAM21 gene

Protein Domains /
Families
for ADAM21 gene

Function
for ADAM21 gene

Pathways & Interactions
for ADAM21 gene

Drugs & Compounds
for ADAM21 gene

Transcripts
for ADAM21 gene

Expression
for ADAM21 gene

Orthologs
for ADAM21 gene

Paralogs
for ADAM21 gene

Genomic Variants
for ADAM21 gene

Disorders / Diseases
for ADAM21 gene

Publications
for ADAM21 gene

External Searches for ADAM21 gene

Genome Databases showing ADAM21 gene

Other Databases showing ADAM21 gene

Specialized Databases showing ADAM21 gene

Intellectual Property
for ADAM21 gene

Products
for ADAM21 gene

View Random Gene

Advanced Search

Export list of displayed genes

ADAM21 Gene

ADAM metallopeptidase domain 21

Aliasesfor ADAM21 gene

Summariesfor ADAM21 gene

Genomic Viewsfor ADAM21 gene

Proteinsfor ADAM21 gene

Protein Domains /Familiesfor ADAM21 gene

Functionfor ADAM21 gene

Pathways & Interactionsfor ADAM21 gene

Drugs & Compoundsfor ADAM21 gene

Transcriptsfor ADAM21 gene

Expression for ADAM21 gene

Orthologsfor ADAM21 gene

Paralogsfor ADAM21 gene

Genomic Variantsfor ADAM21 gene

Disorders / Diseasesfor ADAM21 gene

Publicationsfor ADAM21 gene

External Searches for ADAM21 gene

Genome Databases showing ADAM21 gene

Other Databases showing ADAM21 gene

Specialized Databases showing ADAM21 gene

Intellectual Propertyfor ADAM21 gene

Productsfor ADAM21 gene

View Random Gene

Aliases
for ADAM21 gene

Summaries
for ADAM21 gene

Genomic Views
for ADAM21 gene

Proteins
for ADAM21 gene

Protein Domains /
Families
for ADAM21 gene

Function
for ADAM21 gene

Pathways & Interactions
for ADAM21 gene

Drugs & Compounds
for ADAM21 gene

Transcripts
for ADAM21 gene

Expression
for ADAM21 gene

Orthologs
for ADAM21 gene

Paralogs
for ADAM21 gene

Genomic Variants
for ADAM21 gene

Disorders / Diseases
for ADAM21 gene

Publications
for ADAM21 gene

Intellectual Property
for ADAM21 gene

Products
for ADAM21 gene