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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM21 Gene

protein-coding   GIFtS: 49
GCID: GC14P070924

ADAM Metallopeptidase Domain 21

(Previous name: a disintegrin and metalloproteinase domain 21)
  Search for ADAM21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 211 2     ADAM Metallopeptidase Domain 21, Preproprotein2
A Disintegrin And Metalloproteinase Domain 211 2     Disintegrin And Metalloproteinase Domain-Containing Protein 212
ADAM 212 3     EC 3.4.24.-3
ADAM312     

External Ids:    HGNC: 2001   Entrez Gene: 87472   Ensembl: ENSG000001399857   OMIM: 6037135   UniProtKB: Q9UKJ83   

Export aliases for ADAM21 gene to outside databases

Previous GC identifers: GC14P068429 GC14P064720 GC14P068914 GC14P068688 GC14P069993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM21 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The expression of this gene expression is testis-specific. (provided by RefSeq,
May 2011)

GeneCards Summary for ADAM21 Gene: 
ADAM21 (ADAM metallopeptidase domain 21) is a protein-coding gene. Among its related super-pathways are Interaction With The Zona Pellucida. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8
Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions
associated with establishing and maintaining gradients of ions or nutrients




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM21 gene promoter:
         Pbx1a   C/EBPalpha   E47   RORalpha2   CHOP-10   POU2F1   POU2F1a   Hand1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM21 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.1

ADAM21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM21 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P070924:  view genomic region     (about GC identifiers)

Start:
70,918,874 bp from pter      End:
70,926,622 bp from pter
Size:
7,749 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 21 precursor  
Size: 722 amino acids; 80834 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
Secondary accessions: O43507 Q2VPC6 Q32MR0

Explore the universe of human proteins at neXtProt for ADAM21: NX_Q9UKJ8

Explore proteomics data for ADAM21 at MOPED 

Post-translational modifications:

  • UniProtKB: Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKJ8

  • ADAM21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAM21 Protein Expression
    REFSEQ proteins: NP_003804.2  
    ENSEMBL proteins: 
     ENSP00000474385   ENSP00000267499  
    Reactome Protein details: Q9UKJ8
    Human Recombinant Protein Products for ADAM21: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADAM21
    GenScript Custom Purified and Recombinant Proteins Services for ADAM21
    Novus Biologicals ADAM21 Protein
    Novus Biologicals ADAM21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM21 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    ADAM21 for ontologies           About GeneDecksing



    ADAM21 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ADAM21 

    Assay Products for ADAM21: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAM21 
    Cloud-Clone Corp. CLIAs for ADAM21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM21 
    ADAM

    5/7 InterPro protein domains (see all 7):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9UKJ8

    ProtoNet protein and cluster: Q9UKJ8

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8
    Domain: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding
    Domain: The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg
    fusion
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA21_HUMAN, Q9UKJ8
    Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions
    associated with establishing and maintaining gradients of ions or nutrients

         Genatlas biochemistry entry for ADAM21:
    a disintegrin and metalloprotease (active) domain 21,membrane anchored cell surface adhesion protein,testis
    specific with similarity to fertilin-alpha

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity TAS9469942
    GO:0008270zinc ion binding IEA--
         
    ADAM21 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Adam21):
     normal 

    ADAM21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam21tm1Lex for ADAM21

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM21 

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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of ADAM21 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAM21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fertilization
    Fertilization0.38
    Interaction With The Zona Pellucida0.38
    Reproduction0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ADAM21
        Fertilization
    Reproduction
    Interaction With The Zona Pellucida



    ADAM21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM21

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--
    GO:0032504multicellular organism reproduction TAS--

    ADAM21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM21 (ADA21)

    Search CenterWatch for drugs/clinical trials and news about ADAM21 / ADA21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAM21 gene: 
    NM_003813.3  

    Unigene Cluster for ADAM21:

    ADAM metallopeptidase domain 21
    Hs.178748  [show with all ESTs]
    Unigene Representative Sequence: NM_003813
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603540 ENST00000267499(uc021rvq.1)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM21
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADAM21
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAM21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM21
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                         Customized lentivirus expression plasmids for stable overexpression of ADAM21 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM21
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM21

    Additional mRNA sequence: 

    AF029900.1 BC109024.1 BC109025.1 

    1 DOTS entry:

    DT.103709 

    4 AceView cDNA sequences:

    BX089075 AF029900 BU619464 NM_003813 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTATCTA
    ADAM21 Expression
    About this image


    See ADAM21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM21

    SOURCE GeneReport for Unigene cluster: Hs.178748
        SABiosciences Custom PCR Arrays for ADAM21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM21 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam211 , 5 a disintegrin and metallopeptidase domain 211, 5 78.14(n)1
    69.1(a)1
      12 (37.79 cM)5
    566221  NM_020330.41  NP_065063.11 
     815585845 
    chicken
    (Gallus gallus)
    Aves --
    --
    39(a)
    1 → many
    5(26725432-26727609)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    42(a)
    42(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    GL343318.1(1387820-1389757)
    GL343318.1(1397144-1399132)


    ENSEMBL Gene Tree for ADAM21 (if available)
    TreeFam Gene Tree for ADAM21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM21 gene
    ADAM72  ADAM322  ADAM192  ADAM122  ADAM182  ADAM332  ADAM302  ADAM22  
    ADAM282  ADAM292  ADAM202  ADAM92  ADAM152  ADAM82  
    13 SIMAP similar genes for ADAM21 using alignment to 1 protein entry:     ADA21_HUMAN:
    ADAM20    ADAM29    ADAM30    ADAM9    ADAM23    ADAM19
    ADAM32    ADAM12    ADAM18    ADAM22    ADAM2    ADAM7
    ADAM33

    ADAM21 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for ADAM21 (see all 7)
    PGOHUM00000239927 PGOHUM00000257964 PGOHUM00000247914 PGOHUM00000246615 PGOHUM00000246632


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/313 SNPs in ADAM21 are shown (see all 313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380159021,2
    --70916893(+) AGTTTC/TCCCAT 1 -- us2k10--------
    rs1840587221,2
    --70916902(+) ATGACA/TTTTGG 1 -- us2k10--------
    rs1888307611,2
    C--70916913(+) GTGGAA/GAAGGA 1 -- us2k10--------
    rs727357531,2
    C,F--70916922(+) GATGGT/GTATTT 1 -- us2k13Minor allele frequency- G:0.07CSA WA NA 239
    rs1426993161,2
    --70916947(+) GTCTCG/TCCAGA 1 -- us2k10--------
    rs1460245811,2
    --70917003(+) GTCTTC/TTTGTT 1 -- us2k10--------
    rs1400350251,2
    --70917035(+) TGTTAC/TAGGCT 1 -- us2k10--------
    rs732919611,2
    C,F--70917089(+) ACCATG/ATTATT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1493410861,2
    --70917287(+) GTCTCA/TTCAGT 1 -- us2k10--------
    rs1816326161,2
    --70917321(+) AAACAA/TTGTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAM21 (70918874 - 70926622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADAM21:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902075CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM21
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADAM21 for disorders           About MalaCards
    OMIM gene information: 603713    OMIM disorders: --


    ADAM21 for disorders           About GeneDecksing


    Export disorders for ADAM21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM21 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADAM21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942)1, 2, 3 Hooft van Huijsduijnen R. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2 Poindexter K....Cerretti D.P. (1999)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8747 HGNC: 200 AceView: ADAM21 Ensembl:ENSG00000139985 euGenes: HUgn8747
    ECgene: ADAM21 H-InvDB: ADAM21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAM21 gene:
    Search GeneIP for patents involving ADAM21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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