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Aliases for ADAM21 Gene

Aliases for ADAM21 Gene

  • ADAM Metallopeptidase Domain 21 2 3
  • A Disintegrin And Metalloproteinase Domain 21 2 3
  • ADAM 21 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 21 3
  • ADAM Metallopeptidase Domain 21, Preproprotein 3
  • EC 3.4.24.- 4
  • ADAM31 3

External Ids for ADAM21 Gene

Previous GeneCards Identifiers for ADAM21 Gene

  • GC14P068429
  • GC14P064720
  • GC14P068914
  • GC14P068688
  • GC14P069993
  • GC14P070924

Summaries for ADAM21 Gene

Entrez Gene Summary for ADAM21 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

GeneCards Summary for ADAM21 Gene

ADAM21 (ADAM Metallopeptidase Domain 21) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM21 Gene

  • May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM21 Gene

Genomics for ADAM21 Gene

Regulatory Elements for ADAM21 Gene

Genomic Location for ADAM21 Gene

70,452,157 bp from pter
70,459,905 bp from pter
7,749 bases
Plus strand

Genomic View for ADAM21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM21 Gene

Proteins for ADAM21 Gene

  • Protein details for ADAM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 21
    Protein Accession:
    Secondary Accessions:
    • O43507
    • Q2VPC6
    • Q32MR0

    Protein attributes for ADAM21 Gene

    722 amino acids
    Molecular mass:
    80834 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    • May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human

neXtProt entry for ADAM21 Gene

Proteomics data for ADAM21 Gene at MOPED

Post-translational modifications for ADAM21 Gene

  • Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated
  • Glycosylation at Asn164, Asn227, Asn377, Asn437, Asn478, Asn546, and Asn600
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAM21 Gene

Domains for ADAM21 Gene

Gene Families for ADAM21 Gene

  • ADAM :ADAM metallopeptidase domain containing

Suggested Antigen Peptide Sequences for ADAM21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UKJ8
  • A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding
  • The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM21: view

Function for ADAM21 Gene

Molecular function for ADAM21 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease (active) domain 21,membrane anchored cell surface adhesion protein,testis specific with similarity to fertilin-alpha
UniProtKB/Swiss-Prot Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients

Enzyme Numbers (IUBMB) for ADAM21 Gene

Gene Ontology (GO) - Molecular Function for ADAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 9469942
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM21: view

Phenotypes for ADAM21 Gene

MGI mutant phenotypes for ADAM21:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ADAM21: view

Animal Model Products

CRISPR Products

miRNA for ADAM21 Gene

miRTarBase miRNAs that target ADAM21

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM21

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAM21 Gene

Localization for ADAM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM21 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ADAM21 Gene COMPARTMENTS Subcellular localization image for ADAM21 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0043005 neuron projection --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with ADAM21: view

Pathways for ADAM21 Gene

SuperPathways for ADAM21 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ADAM21: view

Pathways by source for ADAM21 Gene

3 Reactome pathways for ADAM21 Gene

Interacting Proteins for ADAM21 Gene

Gene Ontology (GO) - Biological Process for ADAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with ADAM21: view

Transcripts for ADAM21 Gene

mRNA/cDNA for ADAM21 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM21 Gene

ADAM metallopeptidase domain 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM21
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM21 Gene

No ASD Table

Relevant External Links for ADAM21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM21 Gene

mRNA expression in normal human tissues for ADAM21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM21 Gene

This gene is overexpressed in Testis (22.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADAM21 Gene

SOURCE GeneReport for Unigene cluster for ADAM21 Gene Hs.178748

genes like me logo Genes that share expressions with ADAM21: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADAM21 Gene

Orthologs for ADAM21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAM21 35
  • 98.89 (n)
  • 99.03 (a)
ADAM21 36
  • 99 (a)
(Bos Taurus)
Mammalia ADAM21 35
  • 80.72 (n)
  • 74.07 (a)
ADAM21 36
  • 70 (a)
(Canis familiaris)
Mammalia ADAM21 35
  • 81.92 (n)
  • 75.52 (a)
ADAM21 36
  • 76 (a)
(Mus musculus)
Mammalia Adam21 35
  • 78.14 (n)
  • 69.1 (a)
Adam21 16
Adam21 36
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
LOC100857840 35
  • 52.36 (n)
  • 43.51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
-- 36
  • 40 (a)
-- 36
  • 40 (a)
-- 36
  • 40 (a)
(Danio rerio)
Actinopterygii zgc:174164 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Neu3 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea adm-2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 31 (a)
Species with no ortholog for ADAM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM21 Gene

Gene Tree for ADAM21 (if available)
Gene Tree for ADAM21 (if available)

Paralogs for ADAM21 Gene

Selected SIMAP similar genes for ADAM21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM21: view

Variants for ADAM21 Gene

Sequence variations from dbSNP and Humsavar for ADAM21 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1892282 -- 70,452,602(+) ACCTC(A/G)TGATC intron-variant
rs1892283 -- 70,452,636(+) GCTGG(G/T)ATTAC intron-variant
rs1892284 -- 70,453,021(+) ATTTT(A/G)TCTTT intron-variant
rs1892285 -- 70,453,535(+) TCTGG(C/T)TTTAA intron-variant
rs2000352 -- 70,456,464(+) CCTAA(A/T)ATACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM21 Gene

Variant ID Type Subtype PubMed ID
nsv902075 CNV Gain 21882294

Relevant External Links for ADAM21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM21 Gene

Disorders for ADAM21 Gene

No disorders were found for ADAM21 Gene.

No data available for UniProtKB/Swiss-Prot for ADAM21 Gene

Publications for ADAM21 Gene

  1. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PMID: 9469942) Hooft van Huijsduijnen R. (Gene 1998) 2 3 4
  2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PMID: 10524237) Poindexter K. … Cerretti D.P. (Gene 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4

Products for ADAM21 Gene

Sources for ADAM21 Gene

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