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Aliases for ADAM20 Gene

Aliases for ADAM20 Gene

  • ADAM Metallopeptidase Domain 20 2 3 5
  • A Disintegrin And Metalloproteinase Domain 20 2
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • ADAM 20 4

External Ids for ADAM20 Gene

Previous GeneCards Identifiers for ADAM20 Gene

  • GC14M068494
  • GC14M064785
  • GC14M068979
  • GC14M070058
  • GC14M070989
  • GC14M051157

Summaries for ADAM20 Gene

Entrez Gene Summary for ADAM20 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM20 Gene

ADAM20 (ADAM Metallopeptidase Domain 20) is a Protein Coding gene. Among its related pathways are Reproduction. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM20 Gene

  • May be involved in sperm maturation and/or fertilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM20 Gene

Genomics for ADAM20 Gene

Regulatory Elements for ADAM20 Gene

Enhancers for ADAM20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAM20 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ADAM20 gene promoter:

Genomic Location for ADAM20 Gene

70,520,877 bp from pter
70,557,701 bp from pter
36,825 bases
Minus strand

Genomic View for ADAM20 Gene

Genes around ADAM20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM20 Gene

Proteins for ADAM20 Gene

  • Protein details for ADAM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 20
    Protein Accession:
    Secondary Accessions:
    • Q6GTZ1
    • Q9UKJ9

    Protein attributes for ADAM20 Gene

    726 amino acids
    Molecular mass:
    81603 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human.
    • Sequence=AAH25378.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH25378.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW81037.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ADAM20 Gene

Proteomics data for ADAM20 Gene at MOPED

Selected DME Specific Peptides for ADAM20 Gene

Post-translational modifications for ADAM20 Gene

  • Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
  • Glycosylation at Asn 191, Asn 226, Asn 378, Asn 438, Asn 479, and Asn 587
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADAM20 Gene

Gene Families for ADAM20 Gene

Suggested Antigen Peptide Sequences for ADAM20 Gene

Graphical View of Domain Structure for InterPro Entry



  • A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
  • A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
  • The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM20: view

Function for ADAM20 Gene

Molecular function for ADAM20 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 20,membrane anchored cell surface adhesion protein,testis specific with similarity to fertilin-alpha
UniProtKB/Swiss-Prot Function:
May be involved in sperm maturation and/or fertilization.

Enzyme Numbers (IUBMB) for ADAM20 Gene

genes like me logo Genes that share phenotypes with ADAM20: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM20 Gene

Localization for ADAM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM20 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ADAM20 Gene COMPARTMENTS Subcellular localization image for ADAM20 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for ADAM20 Gene

Pathways & Interactions for ADAM20 Gene

SuperPathways for ADAM20 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ADAM20: view

Pathways by source for ADAM20 Gene

3 Reactome pathways for ADAM20 Gene

Interacting Proteins for ADAM20 Gene

Gene Ontology (GO) - Biological Process for ADAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization TAS 9469942
genes like me logo Genes that share ontologies with ADAM20: view

No data available for SIGNOR curated interactions for ADAM20 Gene

Drugs & Compounds for ADAM20 Gene

No Compound Related Data Available

Transcripts for ADAM20 Gene

mRNA/cDNA for ADAM20 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM20 Gene

ADAM metallopeptidase domain 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM20 Gene

No ASD Table

Relevant External Links for ADAM20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM20 Gene

mRNA expression in normal human tissues for ADAM20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM20 Gene

This gene is overexpressed in Testis (x21.1).

Protein differential expression in normal tissues from HIPED for ADAM20 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM20 Gene

SOURCE GeneReport for Unigene cluster for ADAM20 Gene Hs.177984

mRNA Expression by UniProt/SwissProt for ADAM20 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with ADAM20: view

Protein tissue co-expression partners for ADAM20 Gene

- Elite partner

Primer Products

Orthologs for ADAM20 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC519654 35
  • 78.85 (n)
  • 71.45 (a)
ADAM20 36
  • 70 (a)
(Mus musculus)
Mammalia Adam25 35
  • 64.34 (n)
  • 51.26 (a)
Adam39 16
Gm5346 36
  • 43 (a)
(Pan troglodytes)
Mammalia ADAM20 35
  • 99.57 (n)
  • 99.1 (a)
ADAM20 36
  • 99 (a)
(Canis familiaris)
Mammalia ADAM20 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
-- 36
  • 43 (a)
-- 36
  • 40 (a)
-- 36
  • 40 (a)
-- 36
  • 41 (a)
-- 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Neu3 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea adm-2 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 32 (a)
Species with no ortholog for ADAM20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM20 Gene

Gene Tree for ADAM20 (if available)
Gene Tree for ADAM20 (if available)

Paralogs for ADAM20 Gene

(12) SIMAP similar genes for ADAM20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM20: view

Variants for ADAM20 Gene

Sequence variations from dbSNP and Humsavar for ADAM20 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_047311 -
rs7141562 -- 70,556,701(+) CCCTC(C/T)GCAAA upstream-variant-2KB, utr-variant-5-prime
rs8018765 -- 70,555,610(+) ACTTA(C/T)TGAAA intron-variant
rs7144572 -- 70,553,580(+) TAAAA(A/T)GATCA intron-variant
rs2877683 -- 70,558,978(+) tctct(C/G)tactc upstream-variant-2KB

Variation tolerance for ADAM20 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADAM20 Gene

Disorders for ADAM20 Gene

Relevant External Links for ADAM20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADAM20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM20 Gene

Publications for ADAM20 Gene

  1. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PMID: 9469942) Hooft van Huijsduijnen R. (Gene 1998) 2 3 4 67
  2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  3. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. (PMID: 11807715) Yoshimura T. … Crabtree J.E. (J. Infect. Dis. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PMID: 10524237) Poindexter K. … Cerretti D.P. (Gene 1999) 3

Products for ADAM20 Gene

Sources for ADAM20 Gene