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Aliases for ADAM20 Gene

Aliases for ADAM20 Gene

  • ADAM Metallopeptidase Domain 20 2 3
  • A Disintegrin And Metalloproteinase Domain 20 2
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • ADAM 20 4

External Ids for ADAM20 Gene

Previous GeneCards Identifiers for ADAM20 Gene

  • GC14M068494
  • GC14M064785
  • GC14M068979
  • GC14M070058
  • GC14M070989
  • GC14M051157

Summaries for ADAM20 Gene

Entrez Gene Summary for ADAM20 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM20 Gene

ADAM20 (ADAM Metallopeptidase Domain 20) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM20 Gene

  • May be involved in sperm maturation and/or fertilization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM20 Gene

Genomics for ADAM20 Gene

Regulatory Elements for ADAM20 Gene

Transcription factor binding sites by QIAGEN in the ADAM20 gene promoter:

Genomic Location for ADAM20 Gene

70,522,358 bp from pter
70,556,039 bp from pter
33,682 bases
Minus strand

Genomic View for ADAM20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM20 Gene

Proteins for ADAM20 Gene

  • Protein details for ADAM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 20
    Protein Accession:
    Secondary Accessions:
    • Q6GTZ1
    • Q9UKJ9

    Protein attributes for ADAM20 Gene

    726 amino acids
    Molecular mass:
    81603 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    • May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
    • Sequence=AAH25378.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH25378.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW81037.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ADAM20 Gene

Proteomics data for ADAM20 Gene at MOPED

Selected DME Specific Peptides for ADAM20 Gene

Post-translational modifications for ADAM20 Gene

  • Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated
  • Glycosylation at Asn191, Asn226, Asn378, Asn438, Asn479, and Asn587
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM20 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADAM20 Gene

Gene Families for ADAM20 Gene

  • ADAM :ADAM metallopeptidase domain containing

Suggested Antigen Peptide Sequences for ADAM20 Gene

Graphical View of Domain Structure for InterPro Entry



  • O43506
  • A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding
  • The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM20: view

Function for ADAM20 Gene

Molecular function for ADAM20 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 20,membrane anchored cell surface adhesion protein,testis specific with similarity to fertilin-alpha
UniProtKB/Swiss-Prot Function:
May be involved in sperm maturation and/or fertilization

Enzyme Numbers (IUBMB) for ADAM20 Gene

Gene Ontology (GO) - Molecular Function for ADAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 9469942
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM20: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM20

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM20 Gene

Localization for ADAM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM20 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ADAM20 Gene COMPARTMENTS Subcellular localization image for ADAM20 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM20: view

Pathways for ADAM20 Gene

SuperPathways for ADAM20 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ADAM20: view

Pathways by source for ADAM20 Gene

3 Reactome pathways for ADAM20 Gene

Interacting Proteins for ADAM20 Gene

Gene Ontology (GO) - Biological Process for ADAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with ADAM20: view

Transcripts for ADAM20 Gene

mRNA/cDNA for ADAM20 Gene

(9) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM20 Gene

ADAM metallopeptidase domain 20:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM20

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM20 Gene

No ASD Table

Relevant External Links for ADAM20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM20 Gene

mRNA expression in normal human tissues for ADAM20 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM20 Gene

This gene is overexpressed in Testis (21.1).

Protein differential expression in normal tissues for ADAM20 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM20 Gene

SOURCE GeneReport for Unigene cluster for ADAM20 Gene Hs.177984

mRNA Expression by UniProt/SwissProt for ADAM20 Gene

Tissue specificity: Testis specific
genes like me logo Genes that share expressions with ADAM20: view

Expression partners for ADAM20 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADAM20 Gene

Orthologs for ADAM20 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC519654 35
  • 78.85 (n)
  • 71.45 (a)
ADAM20 36
  • 70 (a)
(Mus musculus)
Mammalia Adam25 35
  • 64.34 (n)
  • 51.26 (a)
Adam20 16
Gm5346 36
  • 43 (a)
(Pan troglodytes)
Mammalia ADAM20 35
  • 99.57 (n)
  • 99.1 (a)
ADAM20 36
  • 99 (a)
(Canis familiaris)
Mammalia ADAM20 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
-- 36
  • 43 (a)
-- 36
  • 40 (a)
-- 36
  • 40 (a)
-- 36
  • 41 (a)
-- 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Neu3 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea adm-2 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 32 (a)
Species with no ortholog for ADAM20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM20 Gene

Gene Tree for ADAM20 (if available)
Gene Tree for ADAM20 (if available)

Paralogs for ADAM20 Gene

Selected SIMAP similar genes for ADAM20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAM20: view

Variants for ADAM20 Gene

Sequence variations from dbSNP and Humsavar for ADAM20 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1059166 - 70,524,701(-) TGGTT(G/T)GGGAT missense, reference
rs1059167 -- 70,522,399(-) TTACT(C/T)TACAG utr-variant-3-prime
rs1538403 -- 70,535,470(+) ATTTT(A/G)AACAT upstream-variant-2KB, intron-variant
rs1953803 -- 70,533,848(+) GAGGC(C/T)AAGGT intron-variant
rs2211071 -- 70,542,990(+) attgt(A/G)tgcaa intron-variant

Relevant External Links for ADAM20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAM20 Gene

Disorders for ADAM20 Gene

No disorders were found for ADAM20 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ADAM20 Gene

Publications for ADAM20 Gene

  1. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PMID: 9469942) Hooft van Huijsduijnen R. (Gene 1998) 2 3 4
  2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PMID: 10524237) Poindexter K. … Cerretti D.P. (Gene 1999) 3 4
  3. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. (PMID: 11807715) Yoshimura T. … Crabtree J.E. (J. Infect. Dis. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for ADAM20 Gene

Sources for ADAM20 Gene

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