Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADAM20 Gene

protein-coding   GIFtS: 51
GCID: GC14M070989

ADAM Metallopeptidase Domain 20

(Previous name: a disintegrin and metalloproteinase domain 20)
  Search for ADAM20
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADAM Metallopeptidase Domain 201 2     EC 3.4.24.-3
A Disintegrin And Metalloproteinase Domain 201 2     EC 3.4.248
ADAM 202 3     EC 3.4.24.588
Disintegrin And Metalloproteinase Domain-Containing Protein 202     

External Ids:    HGNC: 1991   Entrez Gene: 87482   Ensembl: ENSG000001340077   OMIM: 6037125   UniProtKB: O435063   

Export aliases for ADAM20 gene to outside databases

Previous GC identifers: GC14M068494 GC14M064785 GC14M068979 GC14M070058 GC14M051157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADAM20 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The expression of this gene is testis-specific. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM20 Gene:
ADAM20 (ADAM metallopeptidase domain 20) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506
Function: May be involved in sperm maturation and/or fertilization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM20 gene promoter:
         RFX1   MIF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM20 promoter sequence
   Search Chromatin IP Primers for ADAM20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

ADAM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM20 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M070989:  view genomic region     (about GC identifiers)

Start:
70,989,075 bp from pter      End:
71,001,732 bp from pter
Size:
12,658 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 20 precursor  
Size: 726 amino acids; 81603 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Miscellaneous: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
Sequence caution: Sequence=AAH25378.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH25378.2; Type=Erroneous initiation; Sequence=EAW81037.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Secondary accessions: Q6GTZ1 Q9UKJ9

Explore the universe of human proteins at neXtProt for ADAM20: NX_O43506

Explore proteomics data for ADAM20 at MOPED

Post-translational modifications: 

  • Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated1
  • Glycosylation2 at Asn191, Asn226, Asn378, Asn438, Asn479, Asn587
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ADAM20 (O43506)
     GEECDCG  PEVVIPL  HELGHNLG  EEGEECDCG 


    See ADAM20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003805.3  
    ENSEMBL proteins: 
     ENSP00000256389  
    Reactome Protein details: O43506

    ADAM20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADAM20
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAM20
    GenScript Custom Purified and Recombinant Proteins Services for ADAM20
    Novus Biologicals ADAM20 Protein
    Novus Biologicals ADAM20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM20

    ADAM20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM20
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADAM20
    OriGene Custom Antibody Services for ADAM20
    Novus Biologicals ADAM20 Antibodies
    Abcam antibodies for ADAM20
    Cloud-Clone Corp. Antibodies for ADAM20
    ThermoFisher Antibodies for ADAM20
    LSBio Antibodies in human, mouse, rat for ADAM20

    ADAM20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAM20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADAM20
    Cloud-Clone Corp. CLIAs for ADAM20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM20
    ADAM

    Selected InterPro protein domains (see all 6):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry O43506

    ProtoNet protein and cluster: O43506

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506
    Domain: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding
    Domain: The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg
    fusion
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA20_HUMAN, O43506
    Function: May be involved in sperm maturation and/or fertilization

         Genatlas biochemistry entry for ADAM20:
    a disintegrin and metalloprotease (active) domain 20,membrane anchored cell surface adhesion protein,testis
    specific with similarity to fertilin-alpha

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242 EC 3.4.24.582

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity TAS9469942
    GO:0008270zinc ion binding IEA--
         
    ADAM20 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM20

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ADAM20 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ADAM20
    SwitchGear 3'UTR luciferase reporter plasmidADAM20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAM20
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAM20

    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM20 (see all 7)
    OriGene ORF clones in mouse, rat for ADAM20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM20 (NM_003814)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAM20
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ADA20_HUMAN, O43506: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    ADAM20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADAM20 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAM20
        Interaction With The Zona Pellucida



    ADAM20 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM20
    Interactions:

        Search GeneGlobe Interaction Network for ADAM20

    1 Interacting protein for ADAM20 (O435062) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P310162MINT-8108210
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--
    GO:0032504multicellular organism reproduction TAS--

    ADAM20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM20 (ADA20)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADAM20 gene: 
    NM_003814.4  

    Unigene Cluster for ADAM20:

    ADAM metallopeptidase domain 20
    Hs.177984  [show with all ESTs]
    Unigene Representative Sequence: BC025378
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256389(uc001xme.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADAM20 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ADAM20
    SwitchGear 3'UTR luciferase reporter plasmidADAM20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADAM20
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM20
    Clone
    Products:
         
    OriGene clones in human, mouse for ADAM20 (see all 7)
    OriGene ORF clones in mouse, rat for ADAM20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM20 (NM_003814)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM20
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADAM20
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM20
      QuantiFast Probe-based Assays in human, mouse, rat ADAM20

    Additional mRNA sequence: 

    AF029899.1 BC025378.1 

    1 DOTS entry:

    DT.97781512 

    9 AceView cDNA sequences:

    BX094243 AA400588 NM_003814 AA400496 BV183735 BC025378 AF029899 BG722827 
    BG720144 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADAM20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGATTGC
    ADAM20 Expression
    About this image

    ADAM20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177984

    UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506
    Tissue specificity: Testis specific

        Custom PCR Arrays for ADAM20
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM20
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADAM20
    QuantiTect SYBR Green Assays in human, mouse, rat ADAM20
    QuantiFast Probe-based Assays in human, mouse, rat ADAM20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ADAM20 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam205
    Adam251
    RIKEN cDNA 4930529F22 gene5
    a disintegrin and metallopeptidase domain 25 (testase more1
    64.34(n)1
    51.26(a)1
      8 (23.89 cM)5
    237931  NM_011781.21  NP_035911.21 
     407932735 
    chicken
    (Gallus gallus)
    Aves --
    Gallus gallus disintegrin and metalloproteinase do...
    40(a)
    1 → many
    5(26725432-26727609)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    43(a)
    43(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    GL343318.1(1397144-1399132)
    GL343318.1(1387820-1389757)
    fruit fly
    (Drosophila melanogaster)
    Insecta Neu36
    Neu3
    16(a)
    1 → many
    3R(10491559-10523057)
    worm
    (Caenorhabditis elegans)
    Secernentea adm-26
    Protein ADM-2 (adm-2) mRNA, complete cds
    21(a)
    1 → many
    X(13687973-13695791) WBGene00000074


    ENSEMBL Gene Tree for ADAM20 (if available)
    TreeFam Gene Tree for ADAM20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADAM20 gene
    ADAM72  ADAM192  ADAM122  ADAM332  ADAM302  ADAM282  ADAM292  ADAM212  
    ADAM92  ADAM152  ADAM82  
    12 SIMAP similar genes for ADAM20 using alignment to 1 protein entry:     ADA20_HUMAN:
    ADAM21    ADAM29    ADAM30    ADAM9    ADAM12    ADAM19
    ADAM32    ADAM7    ADAM22    ADAM18    ADAM28    ADAM8

    ADAM20 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ADAM20 (see all 6)
    PGOHUM00000239926 PGOHUM00000247846 PGOHUM00000248218 PGOHUM00000248220 PGOHUM00000258178


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADAM20 (see all 366)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752363921,2
    F--70988655(+) TCAGAG/CGACCA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1922120751,2
    --70988685(+) ACCCCC/TAAGGA 1 -- ds50010--------
    rs1854924321,2
    --70988737(+) AGGGTA/GGTTCT 1 -- ds50010--------
    rs1384870111,2
    --70988831(+) GGTAAG/TCACAC 1 -- ds50010--------
    rs1439488031,2
    --70988854(+) TCCCTC/TCTTCC 1 -- ds50010--------
    rs171082011,2
    C,F,H--70988931(+) AGTTGT/CGTACA 1 -- ds500121Minor allele frequency- C:0.23NA NS EA WA 2484
    rs576361641,2
    C--70988966(+) AAAAA-/AGAGAG 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs591149991,2
    --70988983(+) AAAAAG/AAGAGA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs80104731,2
    C,F--70988993(+) AGAGAG/CAGAGA 1 -- ds50016Minor allele frequency- C:0.22WA NA CSA 246
    rs1506937231,2
    --70989085(+) GGAAAA/CGGAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM20 (70989075 - 71001732 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADAM20: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM20
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603712    OMIM disorders: --


    ADAM20 for disorders           About GeneDecksing


    Export disorders for ADAM20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADAM20 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ADAM20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942)1, 2, 3 Hooft van Huijsduijnen R. (Gene 1998)
    2. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2 Poindexter K.... Cerretti D.P. (Gene 1999)
    3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    6. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. (PubMed id 11807715)1 Yoshimura T....Crabtree J.E. (J. Infect. Dis. 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8748 HGNC: 199 AceView: ADAM20 Ensembl:ENSG00000134007 euGenes: HUgn8748
    ECgene: ADAM20 H-InvDB: ADAM20

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADAM20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAM20 gene:
    Search GeneIP for patents involving ADAM20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM20
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADAM20   OriGene RNAi products in human, mouse, rat for ADAM20  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ADAM20  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADAM20  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADAM20   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADAM20   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAM20   OriGene Custom Protein Services for ADAM20  

     
     
     Block miRNA regulation of human, mouse, rat ADAM20 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAM20
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM20 Predesigned siRNA for gene silencing in human, mouse, rat ADAM20
     QuantiFast Probe-based Assays in human, mouse, rat ADAM20 QuantiTect SYBR Green Assays in human, mouse, rat ADAM20
     Custom PCR Arrays for ADAM20 Search Chromatin IP Primers for ADAM20
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADAM20  Search GeneGlobe Interaction Network for ADAM20
     Regulatory tfbs in ADAM20 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADAM20 GenScript cDNA clones with any tag delivered in your preferred vector for ADAM20
     GenScript Custom Assay Services for ADAM20 GenScript Custom overexpressing Cell Line Services for ADAM20
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ADAM20 (ADA20)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADAM20 antibodies
     ADAM20 proteins
     ADAM20 lysates
     Antibodies for ADAM20
     See all of Abcam's Antibodies, Kits and Proteins for ADAM20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ADAM20
     Antibodies for ADAM20
     ELISAs for ADAM20
     CLIAs for ADAM20



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20
     SwitchGear 3'UTR luciferase reporter plasmids for ADAM20
     SwitchGear Promoter luciferase reporter plasmids for ADAM20
     ThermoFisher Antibodies for ADAM20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM20
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM20
     LSBio Antibodies in human, mouse, rat for ADAM20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAM20 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4