ADAM20 Gene
protein-coding GIFtS: 46
GCID: GC14M070989
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ADAM metallopeptidase domain 20(Previous name: a disintegrin and metalloproteinase domain 20 )
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Aliases
for ADAM20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 201 2 | | EC 3.4.24.-3 | | A Disintegrin And Metalloproteinase Domain 201 2 | | EC 3.4.248 | | ADAM 202 3 | | EC 3.4.24.588 | | Disintegrin And Metalloproteinase Domain-Containing Protein 202 | | |
Export aliases for ADAM20 gene to outside databasesPrevious GC identifers: GC14M068494 GC14M064785 GC14M068979 GC14M070058 GC14M051157 |
Summaries
for ADAM20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM20:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety ofbiological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,and neurogenesis. The expression of this gene is testis-specific. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506Function: May be involved in sperm maturation and/or fertilization
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Genomic Views
for ADAM20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM20 gene promoter:
RFX1 MIF-1 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.1 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.2ADAM20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M070989: view genomic region
(about GC identifiers)
Start:
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70,989,078 bp from pter |
End:
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71,001,732 bp from pter |
Size:
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12,655 bases |
Orientation:
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minus strand |
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Proteins
for ADAM20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 20 precursor Size: 726 amino acids; 81603 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
Sequence caution: Sequence=AAH25378.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH25378.2; Type=Erroneous initiation; Sequence=EAW81037.1; Type=Erroneous initiation; Note=TranslationN-terminally shortened;
Secondary accessions: Q6GTZ1 Q9UKJ9Explore the universe of human proteins at neXtProt for ADAM20: NX_O43506
Post-translational modifications:
Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43506
4 DME Specific Peptides for ADAM20 (O43506)
ADAM20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003805.3
ENSEMBL proteins: ENSP00000256389
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ADAM20 for ontologies About GeneDecksing
ADAM20 Antibody Products:
Assay Products for ADAM20: |
Protein
Domains /
Families
for ADAM20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM20 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O43506ProtoNet protein and cluster: O43506 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506Domain: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrinreceptor and thus could mediate sperm/egg bindingDomain: The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusionDomain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain |
Function
for ADAM20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506Function: May be involved in sperm maturation and/or fertilization Genatlas biochemistry entry for ADAM20:a disintegrin and metalloprotease (active) domain 20,membrane anchored cell surface adhesion protein,testis specificwith similarity to fertilin-alpha
Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242 EC 3.4.24.582
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADAM20 (NM_003814) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ADAM20 for ontologies About GeneDecksing
|
Pathways & Interactions
for ADAM20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM20
1 Interacting protein for ADAM20 (O435062) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
ADAM20 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAM20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAM20
Search CenterWatch for drugs/clinical trials and news about ADAM20 / ADA20
|
Transcripts
for ADAM20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAM20 gene: NM_003814.4 Unigene Cluster for ADAM20: ADAM metallopeptidase domain 20 Hs.177984 [show with all ESTs]Unigene Representative Sequence: BC0253781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000256389(uc001xme.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAM20 (NM_003814) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20 |
Additional cDNA sequence: AF029899.1 BC025378.1 1 DOTS entry: DT.97781512 9 AceView cDNA sequences: AA400588 BX094243 NM_003814 AF029899 BC025378 AA400496 BV183735 BG722827 BG720144
GeneLoc Exon Structure
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Expression
for ADAM20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGGATTGC
About this image
See ADAM20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM20
SOURCE GeneReport for Unigene cluster: Hs.177984
UniProtKB/Swiss-Prot: ADA20_HUMAN, O43506Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for ADAM20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ADAM20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20 |
Orthologs
for ADAM20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ADAM20 gene from 2/14 species (see all 14) About this table
ENSEMBL Gene Tree for ADAM20 (if available)
TreeFam Gene Tree for ADAM20 (if available) |
Paralogs
for ADAM20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAM20 gene
- ADAM72 ADAM192 ADAM122 ADAM232 ADAM332 ADAM112 ADAM302 ADAM222
- ADAM282 ADAM292 ADAM92 ADAM212 ADAM152 ADAM82
14 SIMAP similar genes for ADAM20 using alignment to 1 protein entry: ADA20_HUMAN:ADAM21 ADAM29 ADAM30 ADAM9 ADAM12 ADAM19
ADAM32 ADAM7 ADAM22 ADAM18 ADAM28 ADAM8
ADAM15 ADAM2
ADAM20 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for ADAM20 (see all 6)
PGOHUM00000239926 PGOHUM00000247846 PGOHUM00000248218 PGOHUM00000248220 PGOHUM00000258178
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Genomic Variants
for ADAM20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAM20 (70989078 - 71001732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM20: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM20 |
|
Disorders
/ Diseases
for ADAM20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ADAM20 for disorders About MalaCards
ADAM20 for disorders About GeneDecksing
OMIM gene information: 603712
OMIM disorders: --
Export disorders for ADAM20 gene to outside databases
|
Publications
for ADAM20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAM20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942)1, 2, 3 Hooft van Huijsduijnen R. (1998)
- The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2 Poindexter K....Cerretti D.P. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. (PubMed id 11807715)1 Yoshimura T....Crabtree J.E. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ADAM20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ADAM20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAM20 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ADAM20 gene:
Search GeneIP for patents involving ADAM20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ADAM20 | | OriGene shRNA RFP for ADAM20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM20 | | | OriGene Protein Over-expression Lysate for ADAM20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAM20 | | OriGene 3'-UTR Clone for ADAM20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADAM20 | | OriGene Custom Protein Services for ADAM20 | | | OriGene Custom Immunoassay Development | | |
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 | | | ADAM20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM20 |
|  |  |  | | | | Search ThermoFisher Antibodies for ADAM20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM20 |
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