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ADAM2 Gene

protein-coding   GIFtS: 60
GCID: GC08M039601

ADAM Metallopeptidase Domain 2

(Previous name: fertilin beta)
(Previous symbol: FTNB)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 21 2     CRYN22 5
FTNB1 2 3 5     Fertilin Beta1
Cancer/Testis Antigen 151 2 3     PH-30b2
PH302 3 5     Disintegrin And Metalloproteinase Domain-Containing Protein 22
Fertilin Subunit Beta2 3     PH-303
CT152 3     ADAM 23
PH30-beta2 3     EC 3.4.248
CRYN12 5     

External Ids:    HGNC: 1981   Entrez Gene: 25152   Ensembl: ENSG000001047557   OMIM: 6015335   UniProtKB: Q999653   

Export aliases for ADAM2 gene to outside databases

Previous GC identifers: GC08P038997 GC08M039646 GC08M039342 GC08M039618 GC08M039326 GC08M039720 GC08M038134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM2 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called
fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for ADAM2 Gene:
ADAM2 (ADAM metallopeptidase domain 2) is a protein-coding gene. Diseases associated with ADAM2 include reflex sympathetic dystrophy, and epididymitis. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion
during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into
the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to
one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

Gene Wiki entry for ADAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NT_187577.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM2 gene promoter:
         Max1   USF1   USF2   USF-1:USF-2   PPAR-gamma1   POU2F1   USF-1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM2 promoter sequence
   Search Chromatin IP Primers for ADAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.2

ADAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M039601:  view genomic region     (about GC identifiers)

Start:
39,601,254 bp from pter      End:
39,695,808 bp from pter
Size:
94,555 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 2 precursor  
Size: 735 amino acids; 82457 Da
Miscellaneous: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin
subunit alpha is a pseudogene
Secondary accessions: P78326 Q9UQQ8
Alternative splicing: 2 isoforms:  Q99965-1   Q99965-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM2: NX_Q99965

Explore proteomics data for ADAM2 at MOPED

Post-translational modifications: 

  • The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa1
  • Glycosylation2 at Asn122, Asn220, Asn353, Asn459, Asn566
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ADAM2 (Q99965)
     GEECDCG  LEAGEECDC 


    See ADAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265042.1  NP_001265043.1  NP_001455.3  

    ENSEMBL proteins: 
     ENSP00000343854   ENSP00000369182   ENSP00000265708   ENSP00000429352  
    Reactome Protein details: Q99965

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM2
    ADAM

    Selected InterPro protein domains (see all 6):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q99965

    ProtoNet protein and cluster: Q99965

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
    Domain: A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM2_HUMAN, Q99965
    Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion
    during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into
    the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to
    one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

         Genatlas biochemistry entry for ADAM2:
    a disintegrin and metalloprotease (inactive) domain 2,fertilin,subunit beta,membrane anchored cell surface
    adhesion protein,expressed in male testis,putatively binding to an unknown receptor on oocyte vitelline
    membrane,may be involved in male fertility

         Enzyme Number (IUBMB): EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS9041139
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity TAS9041139
    GO:0008270zinc ion binding IEA--
         
    ADAM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adam2):
     reproductive system 

    ADAM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam2tm1Dgm for ADAM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM2
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    miRTarBase miRNAs that target ADAM2:
    hsa-mir-335-5p (MIRT017910)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADAM2_HUMAN, Q99965: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9041139
    GO:0009986cell surface IEA--

    ADAM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAM2
        Interaction With The Zona Pellucida



    ADAM2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM2
    Interactions:

        GeneGlobe Interaction Network for ADAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ADAM2 (Q999653 ENSP000002657084) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD9P219263, ENSP000000091804I2D: score=1 STRING: ENSP00000009180
    CLGNO149673, ENSP000003266994I2D: score=2 STRING: ENSP00000326699
    CRYABP025113, ENSP000002272514I2D: score=1 STRING: ENSP00000227251
    DNM1Q051933, ENSP000003620144I2D: score=1 STRING: ENSP00000362014
    ITGA9ENSP000002647414STRING: ENSP00000264741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway ----
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--

    ADAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM2

    2 Novoseek inferred chemical compound relationships for ADAM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 51.6 3 9041139 (1), 10338366 (1)
    lipid 0 1 8161498 (1)



    ADAM2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM2 gene (3 alternative transcripts): 
    NM_001278113.1  NM_001278114.1  NM_001464.4  

    Unigene Cluster for ADAM2:

    ADAM metallopeptidase domain 2
    Hs.177959  [show with all ESTs]
    Unigene Representative Sequence: NM_001464
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347580 ENST00000379853 ENST00000265708(uc003xnj.3 uc003xnk.3 uc011lck.2 uc003xnl.3)
    ENST00000521880 ENST00000520434 ENST00000523181

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    Additional mRNA sequence: 

    AJ133005.1 AK301734.1 BC034957.2 BC064547.1 U38805.1 U52370.1 X99374.1 

    3 DOTS entries:

    DT.307751  DT.91756874  DT.97782236 

    Selected AceView cDNA sequences (see all 27):

    AJ133005 BC034957 CD244115 BC064547 BG722023 NM_001464 BU570481 BG771783 
    BG719123 BG719616 BQ432956 U38805 BM560521 BG723538 AA398974 U52370 
    BG772222 BQ441376 BU568582 BG720850 BI460477 BG722572 CD299957 X99374 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                          
    SP2:                                            -                                                                                             
    SP3:                                            -     -     -     -                                   -                                       


    ECgene alternative splicing isoforms for ADAM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATAAGGAA
    ADAM2 Expression
    About this image


    ADAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Spermatozoan Seminiferous Tubules
             testis ; cells in seminiferous ducts   
     
     Gonad
             Spermatozoan Seminiferous Tubules
    ADAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177959

    UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
    Tissue specificity: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal
    tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam21 , 5 a disintegrin and metallopeptidase domain 21, 5 68.88(n)1
    60.88(a)1
      14 (34.36 cM)5
    114951  NM_009618.21  NP_033748.21 
     660273295 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    41(a)
    38(a)
    many → 1
    many → 1
    22(2448492-2459258)
    22(2443241-2448175)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    42(a)
    38(a)
    many → 1
    many → 1
    GL343418.1(598118-623334)
    GL343418.1(650240-673477)


    ENSEMBL Gene Tree for ADAM2 (if available)
    TreeFam Gene Tree for ADAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM2 gene
    ADAM322  ADAM232  ADAM182  ADAM112  ADAM222  ADAMDEC12  
    12 SIMAP similar genes for ADAM2 using alignment to 3 protein entries:     ADAM2_HUMAN (see all proteins):
    ADAM28    ADAM22    ADAM18    ADAM9    ADAM21    ADAM12
    ADAM15    ADAM19    ADAM23    ADAM30    ADAM29    ADAM33

    ADAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM2 (see all 2057)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894105631,2
    --39600881(+) TAATTA/GAGTCA 3 -- ds50010--------
    rs74604291,2
    C,F,H--39600899(+) TGACTA/GTTTTA 3 -- ds500114Minor allele frequency- G:0.07NS EA NA WA CSA 790
    rs1820134981,2
    --39600962(+) ATTACA/GCTTAG 3 -- ds50010--------
    rs1864801321,2
    --39601040(+) TAATCC/TTTGTC 3 -- ds50010--------
    rs70118361,2
    C,F,A,H--39601210(+) TTGATT/CGATTT 3 -- ds500118Minor allele frequency- C:0.37NS EA NA WA 2230
    rs96438711,2
    C,F,A,H--39601215(+) TGATTT/CCAGAC 3 -- ds500122Minor allele frequency- C:0.38NA NS EA WA 2480
    rs1896860221,2
    --39601366(+) ATAGCA/GTAAGA 3 -- ut310--------
    rs1414316941,2
    C--39601460(+) TATATA/GTCATA 3 -- ut310--------
    rs2019791,2
    C--39601485(-) TTGTGA/GTTTTA 3 -- ut312Minor allele frequency- G:0.00MN NA 186
    rs349666521,2
    C--39601595(+) AAATG-/AAAAAA 3 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ADAM2 (39601254 - 39695808 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ADAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667185CNV Deletion23128226
    esv2736904CNV Deletion23290073
    esv2665158CNV Deletion23128226
    nsv526355CNV Loss19592680
    nsv890836CNV Loss21882294
    nsv890840CNV Loss21882294
    nsv890837CNV Loss21882294
    nsv890833CNV Loss21882294
    nsv890839CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601533    OMIM disorders: --

    6 diseases for ADAM2:    
    About MalaCards
    reflex sympathetic dystrophy    epididymitis    infertility    alzheimer's disease
    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for ADAM2:
    Infertility

    ADAM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ADAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with ADAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human fertilin beta subunit. (PubMed id 8702389)1, 2, 3, 9 Gupta S.K.... Hollis G.F. (Biochem. Biophys. Res. Commun. 1996)
    2. Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). (PubMed id 9070941)1, 2, 3, 9 Burkin H.R.... Affara N.A. (Genomics 1997)
    3. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. (PubMed id 9041139)1, 2, 9 Vidaeus C.M....Herr J.C. (Mol. Reprod. Dev. 1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PubMed id 18292840)1, 9 Depa-MartynA^w M....Jedrzejczak P. (Folia Histochem. Cytobiol. 2007)
    6. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. (PubMed id 11882657)1, 9 Eto K....Takada Y. (J. Biol. Chem. 2002)
    7. Testicular and epididymal ADAMs: expression and function during fertilization. (PubMed id 22926424)1 Cho C. (Nat Rev Urol 2012)
    8. Evolutionary divergence and functions of the ADAM and ADAMTS gene families. (PubMed id 19951893)1 Brocker C.N....Nebert D.W. (Hum. Genomics 2009)
    9. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. (PubMed id 17023585)1 Atanackovic D....KrAPger N. (Blood 2007)
    10. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. (PubMed id 16049941)1 Cottrell B.A....Bredesen D.E. (Ann. Neurol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2515 HGNC: 198 AceView: ADAM2 Ensembl:ENSG00000104755 euGenes: HUgn2515
    ECgene: ADAM2 H-InvDB: ADAM2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADAM2 gene:
    Search GeneIP for patents involving ADAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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