Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM2 Gene

protein-coding   GIFtS: 54
GCID: GC08M039601

ADAM metallopeptidase domain 2

(Previous name: fertilin beta )
(Previous symbol: FTNB)
 Explore 3 diseases affiliated with
ADAM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAM2    

Aliases
for ADAM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 21 2     PH-302 3
FTNB1 2 3 5     PH30-Beta1
PH301 2 3 5     ADAM 22 3
CT151 2 3     CRYN12 5
PH-30b1 2     CRYN22 5
Fertilin Beta1 2     Disintegrin And Metalloproteinase Domain-Containing Protein 22
Cancer/Testis Antigen 152 3     EC 3.4.248
Fertilin Subunit Beta2 3     

External Ids:    HGNC: 1981   Entrez Gene: 25152   Ensembl: ENSG000001047557   OMIM: 6015335   UniProtKB: Q999653   

Export aliases for ADAM2 gene to outside databases

Previous GC identifers: GC08P038997 GC08M039646 GC08M039342 GC08M039618 GC08M039326 GC08M039720 GC08M038134


Summaries
for ADAM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM2:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an
important role in sperm-egg interactions. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during
fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct.
Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more
integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

Gene Wiki entry for ADAM2


Genomic Views
for ADAM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM2 gene promoter:
         Max1   USF1   USF2   USF-1:USF-2   PPAR-gamma1   POU2F1   USF-1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.2

ADAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M039601:  view genomic region     (about GC identifiers)

Start:
 39,601,254 bp from pter      End:
 39,695,808 bp from pter
Size:
 94,555 bases      Orientation:
 minus strand

Proteins
for ADAM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 2 precursor  
Size: 735 amino acids; 82457 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit
alpha is a pseudogene
Secondary accessions: P78326 Q9UQQ8
Alternative splicing: 2 isoforms:  Q99965-1   Q99965-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM2: NX_Q99965

Post-translational modifications:

  • The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99965

    • 2 DME Specific Peptides for ADAM2 (Q99965)
     GEECDCG  LEAGEECDC 

    ADAM2 Protein expression data from MOPED and PaxDb:    About this image 
    ADAM2 Protein Expression
    REFSEQ proteins: NP_001455.3  
    ENSEMBL proteins: 
     ENSP00000343854   ENSP00000369182   ENSP00000265708   ENSP00000429352  

    Human Recombinant Protein Products for ADAM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ADAM2 
    GenScript Custom Purified and Recombinant Proteins Services for ADAM2
    Novus Biologicals ADAM2 Proteins
    Novus Biologicals ADAM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAM2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0005887integral to plasma membrane TAS9041139

    ADAM2 for ontologies           About GeneDecksing



    ADAM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADAM2 
    GenScript Custom Superior Antibodies Services for ADAM2
    Novus Biologicals ADAM2 Antibodies
    Abcam antibodies for ADAM2 
    Uscn Antibodies for ADAM2
    Search ThermoFisher Antibodies for ADAM2

    Assay Products for ADAM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAM2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAM2

    Protein Domains /
    Families
    for ADAM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q99965

    ProtoNet protein and cluster: Q99965

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
    Domain: A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAM2_HUMAN, Q99965
    Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during
    fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct.
    Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more
    integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

         Genatlas biochemistry entry for ADAM2:
    a disintegrin and metalloprotease (inactive) domain 2,fertilin,subunit beta,membrane anchored cell surface adhesion
    protein,expressed in male testis,putatively binding to an unknown receptor on oocyte vitelline membrane,may be
    involved in male fertility

         Enzyme Number (IUBMB): EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS9041139
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity TAS9041139
    GO:0008270zinc ion binding IEA--
         
    ADAM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adam2):
     reproductive system 

    ADAM2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Adam2tm1Dgm for ADAM2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM2 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADAM2
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM2 (see all 7)
    OriGene shRNA RFP: ADAM2
    OriGene siRNA: ADAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADAM2
    Sirion Biotech Customized adenovirus for overexpression of ADAM2 
    Sirion Biotech Customized adenovirus for potent knockdown of ADAM2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAM2 (NM_001464)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ADAM2
    Search LifeMap BioReagents cell lines for ADAM2
    Sirion Biotech Customized stable knockdown cell line services for ADAM2 
    Sirion Biotech Customized inducible knockdown cell line services for ADAM2
    Sirion Biotech Customized stable overexpressing cell line services for ADAM2
    Sirion Biotech Customized inducible overexpressing cell line services for ADAM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM2


    Pathways & Interactions
    for ADAM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_ECM remodeling
    		Metalloproteases in connective tissue degradation0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADAM2
        Metalloproteases in connective tissue degradation




    ADAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ADAM2 (Q999653 ENSP000002657084) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD9P219263, ENSP000000091804I2D: score=1 STRING: ENSP00000009180
    CLGNO149673, ENSP000003266994I2D: score=2 STRING: ENSP00000326699
    CRYABP025113, ENSP000002272514I2D: score=1 STRING: ENSP00000227251
    DNM1Q051933, ENSP000003620144I2D: score=1 STRING: ENSP00000362014
    ITGA9ENSP000002647414STRING: ENSP00000264741
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway ----
    GO:0007342fusion of sperm to egg plasma membrane TAS9041139
    GO:0008542visual learning IEA--

    ADAM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM2
    2 Novoseek chemical compound relationships for ADAM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 51.6 3 9041139 (1), 10338366 (1)
    lipid 0 1 8161498 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAM2 

    Transcripts
    for ADAM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM2 gene: 
    NM_001464.3  

    Unigene Cluster for ADAM2:

    ADAM metallopeptidase domain 2
    Hs.177959  [show with all ESTs]
    Unigene Representative Sequence: NM_001464
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347580 ENST00000379853 ENST00000265708(uc003xnj.3 uc003xnk.3 uc011lck.2 uc003xnl.3)
    ENST00000521880 ENST00000520434 ENST00000523181

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADAM2
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM2 (see all 7)
    OriGene shRNA RFP: ADAM2
    OriGene siRNA: ADAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAM2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAM2 (NM_001464)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM2

    Additional cDNA sequence: 

    AJ133005.1 AK301734.1 BC034957.2 BC064547.1 U38805.1 U52370.1 X99374.1 

    3 DOTS entries:

    DT.307751  DT.91756874  DT.97782236 

    24/27 AceView cDNA sequences (see all 27):

    AJ133005 BC064547 BC034957 CD244115 BU570481 BQ432956 BG723538 BG719616 
    BI460477 AA398974 U38805 BM560521 U52370 BG720850 BQ441376 BG719123 
    BU568582 BG771783 BG772222 BG722023 NM_001464 BG722572 CD299957 X99374 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                          
    SP2:                                            -                                                                                             
    SP3:                                            -     -     -     -                                   -                                       


    ECgene alternative splicing isoforms for ADAM2

    Expression
    for ADAM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATAAGGAA
    ADAM2 Expression
    About this image

    ADAM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatozoanGerm Cells, Male Gametocytes
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM2

    SOURCE GeneReport for Unigene cluster: Hs.177959

    UniProtKB/Swiss-Prot: ADAM2_HUMAN, Q99965
    Tissue specificity: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal
    tissues

        SABiosciences Custom PCR Arrays for ADAM2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM2

    Orthologs
    for ADAM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM2 gene from 2/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAM26
    		 Uncharacterized protein
    		 37(a)
    		 1 → many
    		 22(2487128-2497590)
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM26
    		 --
    		 41(a)
    		 1 → many
    		 GL343418.1(598118-621755)


    ENSEMBL Gene Tree for ADAM2 (if available)
    TreeFam Gene Tree for ADAM2 (if available) 

    Paralogs
    for ADAM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM2 gene
    ADAM322  ADAM182  ADAMDEC12  
    13 SIMAP similar genes for ADAM2 using alignment to 3 protein entries:     ADAM2_HUMAN (see all proteins):
    ADAM28    ADAM18    ADAM22    ADAM9    ADAM21    ADAM12
    ADAM15    ADAM19    ADAM23    ADAM30    ADAM29    ADAM33
    ADAM20

    ADAM2 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1730 NCBI SNPs in ADAM2 are shown (see all 1730)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1894105631,2
    		--39600881(+) TAATTA/GAGTCA 1 -- ds50010--------
    rs74604291,2
    		C,F,H--39600899(+) TGACTA/GTTTTA 1 -- ds500114Minor allele frequency- G:0.07NS EA NA WA CSA 790
    rs1820134981,2
    		--39600962(+) ATTACA/GCTTAG 1 -- ds50010--------
    rs1864801321,2
    		--39601040(+) TAATCC/TTTGTC 1 -- ds50010--------
    rs70118361,2
    		C,F,A,H--39601210(+) TTGATT/CGATTT 1 -- ds500118Minor allele frequency- C:0.37NS EA NA WA 2230
    rs96438711,2
    		C,F,A,H--39601215(+) TGATTT/CCAGAC 1 -- ds500122Minor allele frequency- C:0.38NA NS EA WA 2480
    rs1896860221,2
    		--39601366(+) ATAGCA/GTAAGA 1 -- ut310--------
    rs1414316941,2
    		--39601460(+) TATATA/GTCATA 1 -- ut310--------
    rs2019791,2
    		C--39601485(-) TTGTGA/GTTTTA 1 -- ut312Minor allele frequency- G:0.00MN NA 186
    rs349666521,2
    		C--39601595(+) AAATG-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ADAM2 (39601254 - 39695808 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADAM2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM2

    Disorders / Diseases
    for ADAM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM2 for disorders           About GeneDecksing

    OMIM gene information: 601533    OMIM disorders: --

    3 diseases for ADAM2:    About MalaCards
    reflex sympathetic dystrophy    epididymitis    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for ADAM2:
    Infertility

    Export disorders for ADAM2 gene to outside databases

    Publications
    for ADAM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ADAM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human fertilin beta subunit. (PubMed id 8702389)1, 2, 3, 9 Gupta S.K.... Hollis G.F. (1996)
    2. Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). (PubMed id 9070941)1, 2, 3, 9 Burkin H.R.... Affara N.A. (1997)
    3. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. (PubMed id 9041139)1, 2, 9 Vidaeus C.M....Herr J.C. (1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PubMed id 18292840)1, 9 Depa-Martynow M....Jedrzejczak P. (2007)
    6. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. (PubMed id 11882657)1, 9 Eto K....Takada Y. (2002)
    7. A pilot proteomic study of amyloid precursor interact ors in Alzheimer's disease. (PubMed id 16049941)1 Cottrell B.A....Bredesen D.E. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. (PubMed id 11784061)1 Ikawa M....Okabe M. (2001)
    10. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. (PubMed id 10518536)1 Chen M.S....White J.M. (1999)

    External Searches for ADAM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2515 HGNC: 198 AceView: ADAM2 Ensembl:ENSG00000104755 euGenes: HUgn2515
    ECgene: ADAM2 H-InvDB: ADAM2

    Other Databases showing ADAM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM2 gene:
    Search GeneIP for patents involving ADAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ADAM2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ADAM2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ADAM2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAM2   OriGene Custom Protein Services for ADAM2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM2
     GenScript Custom Purified and Recombinant Proteins Services for ADAM2 GenScript cDNA clones with any tag delivered in your preferred vector for ADAM2
     GenScript Custom Assay Services for ADAM2 GenScript Custom Superior Antibodies Services for ADAM2
     GenScript Custom overexpressing Cell Line Services for ADAM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAM2 promoter
     Search Chromatin IP Primers for ADAM2
     RT2 qPCR Primer Assay in human, mouse, rat ADAM2
     GNC Network for ADAM2
     SABiosciences Custom PCR Arrays for ADAM2
     Search Tocris compounds for ADAM2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAM2 antibodies
     ADAM2 proteins
     ADAM2 lysates
     Antibodies for ADAM2
     See all of Abcam's Antibodies, Kits and Proteins for ADAM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ADAM2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ADAM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM2
     SwitchGear 3'UTR luciferase reporter plasmids for ADAM2
     SwitchGear Promoter luciferase reporter plasmids for ADAM2
     Search ThermoFisher Antibodies for ADAM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAM2
    Sirion Biotech Customized:
     stable knockdown cell line services for ADAM2
     inducible knockdown cell line services for ADAM2
     design and validation of potent shRNA sequences against ADAM2
     adenovirus for potent knockdown of ADAM2
     adenovirus for overexpression of ADAM2
     stable overexpressing cell line services for ADAM2
     inducible overexpressing cell line services for ADAM2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ADAM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4