ADAM1A Gene
pseudogene GIFtS: 23
GCID: GC12P112344
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ADAM metallopeptidase domain 1A, pseudogene(Previous names: a disintegrin and metalloproteinase domain 1 (fertilin...)
(Previous symbol: ADAM1)
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Aliases
for ADAM1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| ADAM Metallopeptidase Domain 1A, Pseudogene1 2 | | Ftna1 2 | | ADAM11 2 | | PH-30a1 2 | | ADAM1P1 2 | | A Disintegrin And Metalloproteinase Domain 1 (Fertilin Alpha) Pseudogene1 | | FTNAP1 2 | | ADAM Metallopeptidase Domain 1, Pseudogene1 |
Export aliases for ADAM1A gene to outside databasesPrevious GC identifer: GC12P112340 |
Summaries
for ADAM1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
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Genomic Views
for ADAM1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ADAM1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.13 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.13ADAM1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P112344: view genomic region
(about GC identifiers)
Start:
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112,336,967 bp from pter |
End:
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112,339,606 bp from pter |
Size:
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2,640 bases |
Orientation:
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plus strand |
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Proteins
for ADAM1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for ADAM1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for ADAM1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM1A |
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Pathways & Interactions
for ADAM1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM1A
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Drugs & Compounds
for ADAM1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAM1A
Search CenterWatch for drugs/clinical trials and news about ADAM1A 
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Transcripts
for ADAM1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for ADAM1A: ADAM metallopeptidase domain 1A, pseudogene Hs.661708 [show with all ESTs]Unigene Representative Sequence: NR_0366361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000424240(uc021rea.1)
Additional cDNA sequence: NR_036636.1 3 DOTS entries: DT.431239 DT.99995632 DT.95356734 24/32 AceView cDNA sequences (see all 32): BX089698 BQ021904 BU608242 AW170319 BF593052 BF447933 BI491532 AA297138 AW020185 AW195586 BU101671 AW169454 AA325582 CA427398 BQ186520 BE550836 BU101672 CK301026 AI913501 AA298850 AI765038 AW020518 AW015469 CA310865
GeneLoc Exon Structure
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Expression
for ADAM1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for ADAM1A
SOURCE GeneReport for Unigene cluster: Hs.661708
SABiosciences Custom PCR Arrays for ADAM1A
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ADAM1A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM1A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM1A |
Orthologs
for ADAM1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for ADAM1A (if available)
TreeFam Gene Tree for ADAM1A (if available) |
Paralogs
for ADAM1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for ADAM1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ADAM1A (112336967 - 112339606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM1A: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ADAM1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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ADAM1A for disorders About GeneDecksing
2  diseases for ADAM1A: About MalaCardsepididymitis cataract
Export disorders for ADAM1A gene to outside databases
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Publications
for ADAM1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for ADAM1A gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with ADAM1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human fertilin alpha gene is non-functional: implications for its proposed role in fertilization. (PubMed id 9032439)1, 3, 9 Jury J.A....Hall L. (1997)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. (PubMed id 11784061)1 Ikawa M....Okabe M. (2001)
- The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1 Poindexter K....Cerretti D.P. (1999)
- Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. (PubMed id 8786143)9 Cho C....Myles D.G. (1996)
- Positive selection within sperm-egg adhesion domains of fertilin: an ADAM gene with a potential role in fertilization. (PubMed id 12519902)9 Civetta A. (2003)
- Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation. (PubMed id 10864851)9 Blobel C.P. (2000)
- The transmembrane homotrimer of ADAM 1 in model lipid bilayers. (PubMed id 17189481)9 Gan S.W....Torres J. (2007)
- The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PubMed id 12206465)9 Evans J.P. (2002)
- Transcripts encoding the sperm surface protein tMDC II are non- functional in the human. (PubMed id 10417343)9 Frayne J.... Hall L. (1999)
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External Searches for ADAM1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ADAM1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing ADAM1A gene
(According to HUGE)
About This Section
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Specialized Databases showing ADAM1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ADAM1A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ADAM1A gene:
Search GeneIP for patents involving ADAM1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADAM1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM1A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM1A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM1A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM1A |
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| | | | Search Tocris compounds for ADAM1A |
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 | | | ADAM1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM1A |
|  |  |  | | | | Search ThermoFisher Antibodies for ADAM1A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADAM1A |
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