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Aliases for ADAM19 Gene

Aliases for ADAM19 Gene

  • ADAM Metallopeptidase Domain 19 2 3
  • MLTNB 3 4 6
  • A Disintegrin And Metalloproteinase Domain 19 (Meltrin Beta) 2 3
  • Metalloprotease And Disintegrin Dendritic Antigen Marker 3 4
  • Meltrin-Beta 3 4
  • ADAM 19 3 4
  • MADDAM 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 19 3
  • Metalloprotease-Disintegrin Meltrin Beta 3
  • Meltrin Beta 2
  • EC 3.4.24.- 4
  • EC 3.4.24 64
  • FKSG34 3

External Ids for ADAM19 Gene

Summaries for ADAM19 Gene

Entrez Gene Summary for ADAM19 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM19 Gene

ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM19 Gene

  • Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Gene Wiki entry for ADAM19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM19 Gene

Genomics for ADAM19 Gene

Genomic Location for ADAM19 Gene

Start:
157,395,534 bp from pter
End:
157,575,823 bp from pter
Size:
180,290 bases
Orientation:
Minus strand

Genomic View for ADAM19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM19 Gene

Regulatory Elements for ADAM19 Gene

Proteins for ADAM19 Gene

  • Protein details for ADAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H013-ADA19_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 19
    Protein Accession:
    Q9H013
    Secondary Accessions:
    • Q9BZL5
    • Q9UHP2

    Protein attributes for ADAM19 Gene

    Size:
    955 amino acids
    Molecular mass:
    104997 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with SH3PXD2A.

    Alternative splice isoforms for ADAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM19 Gene

Proteomics data for ADAM19 Gene at MOPED

Selected DME Specific Peptides for ADAM19 Gene

Post-translational modifications for ADAM19 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn144, Thr183, Thr191, Thr194, Asn444, Asn447, and Asn645

Other Protein References for ADAM19 Gene

Domains for ADAM19 Gene

Gene Families for ADAM19 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

ADA19_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9H013
  • Contains 1 disintegrin domain.:
    • Q9H013
  • Contains 1 EGF-like domain.:
    • Q9H013
  • Contains 1 peptidase M12B domain.:
    • Q9H013
genes like me logo Genes that share domains with ADAM19: view

Function for ADAM19 Gene

Molecular function for ADAM19 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in osteoblast differentiation
UniProtKB/Swiss-Prot Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
UniProtKB/Swiss-Prot Induction: By 1,25(OH)2VD3 in monocytes

Enzyme Numbers (IUBMB) for ADAM19 Gene

Gene Ontology (GO) - Molecular Function for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ADAM19: view
genes like me logo Genes that share phenotypes with ADAM19: view

Animal Models for ADAM19 Gene

MGI Knock Outs for ADAM19:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ADAM19 Gene

Localization for ADAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM19 Gene COMPARTMENTS Subcellular localization image for ADAM19 gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM19: view

Pathways for ADAM19 Gene

SuperPathways for ADAM19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006509 membrane protein ectodomain proteolysis IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with ADAM19: view

No data available for Pathways by source for ADAM19 Gene

Transcripts for ADAM19 Gene

Unigene Clusters for ADAM19 Gene

ADAM metallopeptidase domain 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM19 Gene

No ASD Table

Relevant External Links for ADAM19 Gene

GeneLoc Exon Structure for
ADAM19
ECgene alternative splicing isoforms for
ADAM19

Expression for ADAM19 Gene

mRNA expression in normal human tissues for ADAM19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM19 Gene

This gene is overexpressed in Whole Blood (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM19 Gene

SOURCE GeneReport for Unigene cluster for ADAM19 Gene Hs.483944

mRNA Expression by UniProt/SwissProt for ADAM19 Gene

Q9H013-ADA19_HUMAN
Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines
genes like me logo Genes that share expressions with ADAM19: view

Orthologs for ADAM19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM19 36
  • 99.6 (n)
  • 99.56 (a)
ADAM19 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM19 36
  • 87.55 (n)
  • 87.85 (a)
ADAM19 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM19 36
  • 88.55 (n)
  • 89.21 (a)
ADAM19 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam19 36
  • 84.79 (n)
  • 84.06 (a)
Adam19 16
Adam19 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM19 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM19 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam19 36
  • 84.21 (n)
  • 83.95 (a)
chicken
(Gallus gallus)
Aves ADAM19 36
  • 66.02 (n)
  • 62.41 (a)
ADAM19 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM19 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam19 36
  • 62.77 (n)
  • 60.08 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
adam19b 37
  • 49 (a)
OneToOne
LOC571252 36
  • 58.77 (n)
  • 55.73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003498 36
  • 50.61 (n)
  • 40.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Meltrin 36
  • 47.45 (n)
  • 37.99 (a)
mmd 38
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 38
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for ADAM19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM19 Gene

ENSEMBL:
Gene Tree for ADAM19 (if available)
TreeFam:
Gene Tree for ADAM19 (if available)

Paralogs for ADAM19 Gene

genes like me logo Genes that share paralogs with ADAM19: view

Variants for ADAM19 Gene

Sequence variations from dbSNP and Humsavar for ADAM19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10404 -- 157,477,625(-) GGAAC(A/G)CCAAC utr-variant-3-prime
rs868988 -- 157,507,379(-) TAAAC(A/G)ACCTT intron-variant
rs868989 -- 157,507,299(-) TGGAA(G/T)TTGTC intron-variant
rs949799 -- 157,477,773(-) AAGTC(C/T)CTCCC utr-variant-3-prime
rs949800 -- 157,477,626(-) GGGAA(C/T)GCCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADAM19 Gene

Variant ID Type Subtype PubMed ID
nsv830526 CNV Loss 17160897
nsv5089 CNV Loss 18451855
nsv462497 CNV Loss 19166990
nsv883063 CNV Loss 21882294
esv997268 CNV Deletion 20482838
esv6935 CNV Loss 19470904
dgv1868e1 CNV Complex 17122850

Relevant External Links for ADAM19 Gene

HapMap Linkage Disequilibrium report
ADAM19
Human Gene Mutation Database (HGMD)
ADAM19

Disorders for ADAM19 Gene

(3) Novoseek inferred disease relationships for ADAM19 Gene

Disease -log(P) Hits PubMed IDs
necrosis 28.3 1
renal disease 11.4 8
tumors 0 5

Relevant External Links for ADAM19

Genetic Association Database (GAD)
ADAM19
Human Genome Epidemiology (HuGE) Navigator
ADAM19
genes like me logo Genes that share disorders with ADAM19: view

No data available for UniProtKB/Swiss-Prot for ADAM19 Gene

Publications for ADAM19 Gene

  1. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PMID: 9806848) Hirohata S. … Apte S.S. (Genomics 1998) 2 3 23
  2. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PMID: 10887142) Fritsche J. … Kreutz M. (Blood 2000) 3 4 23
  3. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PMID: 11162584) Wei P. … Sang Q.-X.A. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  4. Inhibitory antibodies against endopeptidase activity of human adamalysin 19. (PMID: 11708814) Zhao Y.G. … Sang Q.X. (Biochem. Biophys. Res. Commun. 2001) 3 23
  5. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PMID: 12463424) Huang L. … Li C. (Mol. Biol. Rep. 2002) 3 23

Products for ADAM19 Gene

Sources for ADAM19 Gene

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