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Aliases for ADAM19 Gene

Aliases for ADAM19 Gene

  • ADAM Metallopeptidase Domain 19 2 3 5
  • A Disintegrin And Metalloproteinase Domain 19 (Meltrin Beta) 2 3
  • Metalloprotease And Disintegrin Dendritic Antigen Marker 3 4
  • Meltrin-Beta 3 4
  • ADAM 19 3 4
  • MADDAM 3 4
  • MLTNB 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 19 3
  • Metalloprotease-Disintegrin Meltrin Beta 3
  • Meltrin Beta 2
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • FKSG34 3

External Ids for ADAM19 Gene

Previous GeneCards Identifiers for ADAM19 Gene

  • GC05M156953
  • GC05M156839
  • GC05M156885
  • GC05M156836
  • GC05M151992

Summaries for ADAM19 Gene

Entrez Gene Summary for ADAM19 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM19 Gene

ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. Diseases associated with ADAM19 include Alzheimer Disease. Among its related pathways are A-beta Signaling Pathways and Mesodermal Commitment Pathway. GO annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM12.

UniProtKB/Swiss-Prot for ADAM19 Gene

  • Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Gene Wiki entry for ADAM19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM19 Gene

Genomics for ADAM19 Gene

Regulatory Elements for ADAM19 Gene

Enhancers for ADAM19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G157602 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -27.8 -27785 3.0 HDGF SIN3A BMI1 RAD21 GATA2 FOS ETV6 RELB IKZF2 CREM ADAM19 NIPAL4 HAVCR2 THG1L ENSG00000254336 RNU6-390P
GH05G157510 1.4 Ensembl ENCODE dbSUPER 32.2 +63.3 63328 3.6 ELF3 FOXA2 ARNT SIN3A RAD21 RARA FOS KLF13 CEBPB PPARG NIPAL4 ADAM19 LOC102724404 ENSG00000248544 CYFIP2 ENSG00000253519
GH05G157514 1.4 FANTOM5 Ensembl ENCODE dbSUPER 31.7 +59.4 59421 3.7 PKNOX1 BHLHE40 NR2F1 SIN3A JUNB RAD21 NR2F2 FOSL1 JUND PBX2 ADAM19 LOC102724404 FNDC9 NIPAL4 ENSG00000248544 CYFIP2 HAVCR2 ENSG00000253519
GH05G157594 1.5 FANTOM5 ENCODE dbSUPER 28.5 -21.2 -21195 6.0 TBP PKNOX1 TBL1XR1 NFIB RAD21 YY1 EGR1 SCRT2 FOS RELB ADAM19 NIPAL4 C5orf52 HAVCR2 THG1L ENSG00000254336 RNU6-390P
GH05G157610 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.7 -36.5 -36474 3.9 ARNT FEZF1 TCF12 GATA2 CBX5 ZMIZ1 JUNB NCOA1 REST TBX21 ADAM19 NIPAL4 THG1L C5orf52 FNDC9 ENSG00000254336 GC05P157624
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM19 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189581 823 2801 HDGF WRNIP1 SIN3A GLIS2 KLF7 ZNF263 SP3 ZNF579 ZNF610 GLIS1

Genomic Location for ADAM19 Gene

Chromosome:
5
Start:
157,395,534 bp from pter
End:
157,575,823 bp from pter
Size:
180,290 bases
Orientation:
Minus strand

Genomic View for ADAM19 Gene

Genes around ADAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM19 Gene

Proteins for ADAM19 Gene

  • Protein details for ADAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H013-ADA19_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 19
    Protein Accession:
    Q9H013
    Secondary Accessions:
    • Q9BZL5
    • Q9UHP2

    Protein attributes for ADAM19 Gene

    Size:
    955 amino acids
    Molecular mass:
    104997 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with SH3PXD2A.

    Alternative splice isoforms for ADAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM19 Gene

Selected DME Specific Peptides for ADAM19 Gene

Q9H013:
  • SGGVNMDHS
  • GEECDCG
  • MAHEMGH

Post-translational modifications for ADAM19 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn144, posLast=183183, Thr194, Asn444, posLast=447447, and Asn645
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM19 Gene

Domains & Families for ADAM19 Gene

Gene Families for ADAM19 Gene

Suggested Antigen Peptide Sequences for ADAM19 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H013

UniProtKB/Swiss-Prot:

ADA19_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM19: view

Function for ADAM19 Gene

Molecular function for ADAM19 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in osteoblast differentiation
UniProtKB/Swiss-Prot Function:
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
UniProtKB/Swiss-Prot Induction:
By 1,25(OH)2VD3 in monocytes.

Enzyme Numbers (IUBMB) for ADAM19 Gene

Gene Ontology (GO) - Molecular Function for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ADAM19: view
genes like me logo Genes that share phenotypes with ADAM19: view

Animal Models for ADAM19 Gene

MGI Knock Outs for ADAM19:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM19

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM19 Gene

Localization for ADAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM19 gene
Compartment Confidence
plasma membrane 3
extracellular 3
golgi apparatus 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM19: view

Pathways & Interactions for ADAM19 Gene

genes like me logo Genes that share pathways with ADAM19: view

Pathways by source for ADAM19 Gene

1 BioSystems pathway for ADAM19 Gene
1 R&D Systems pathway for ADAM19 Gene

SIGNOR curated interactions for ADAM19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006509 membrane protein ectodomain proteolysis IEA --
GO:0007507 heart development IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ADAM19: view

Drugs & Compounds for ADAM19 Gene

No Compound Related Data Available

Transcripts for ADAM19 Gene

Unigene Clusters for ADAM19 Gene

ADAM metallopeptidase domain 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM19 Gene

No ASD Table

Relevant External Links for ADAM19 Gene

GeneLoc Exon Structure for
ADAM19
ECgene alternative splicing isoforms for
ADAM19

Expression for ADAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM19 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for ADAM19 Gene

This gene is overexpressed in Prostate (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM19 Gene



Protein tissue co-expression partners for ADAM19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM19 Gene:

ADAM19

SOURCE GeneReport for Unigene cluster for ADAM19 Gene:

Hs.483944

mRNA Expression by UniProt/SwissProt for ADAM19 Gene:

Q9H013-ADA19_HUMAN
Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines.

Evidence on tissue expression from TISSUES for ADAM19 Gene

  • Lymph node(4.3)
  • Spleen(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ADAM19: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM19 Gene

Orthologs for ADAM19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM19 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ADAM19 34 35
  • 88.55 (n)
cow
(Bos Taurus)
Mammalia ADAM19 34 35
  • 87.55 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM19 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam19 34 16 35
  • 84.79 (n)
rat
(Rattus norvegicus)
Mammalia Adam19 34
  • 84.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM19 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM19 34 35
  • 66.02 (n)
lizard
(Anolis carolinensis)
Reptilia ADAM19 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam19 34
  • 62.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC571252 34
  • 58.77 (n)
adam19b 35
  • 49 (a)
OneToOne
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003498 34
  • 50.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Meltrin 34
  • 47.45 (n)
mmd 36
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for ADAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM19 Gene

ENSEMBL:
Gene Tree for ADAM19 (if available)
TreeFam:
Gene Tree for ADAM19 (if available)

Paralogs for ADAM19 Gene

genes like me logo Genes that share paralogs with ADAM19: view

Variants for ADAM19 Gene

Sequence variations from dbSNP and Humsavar for ADAM19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs200894535 A colorectal cancer sample 157,530,816(+) TTCCT(C/T)GGCAA reference, missense
VAR_036147 A colorectal cancer sample
VAR_062670 A pancreatic ductal adenocarcinoma sample
rs863223367 Benign 157,481,931(-) CCAGG(C/T)CTCGG reference, missense
rs1000023822 -- 157,507,961(+) TATCT(C/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM19 Gene

Variant ID Type Subtype PubMed ID
esv2759389 CNV loss 17122850
esv6935 CNV loss 19470904
esv997268 CNV deletion 20482838
nsv462497 CNV loss 19166990
nsv5089 CNV deletion 18451855
nsv600133 CNV loss 21841781
nsv830526 CNV loss 17160897

Variation tolerance for ADAM19 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.82; 96.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM19 Gene

Human Gene Mutation Database (HGMD)
ADAM19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM19 Gene

Disorders for ADAM19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM19 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADAM19

Genetic Association Database (GAD)
ADAM19
Human Genome Epidemiology (HuGE) Navigator
ADAM19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM19
genes like me logo Genes that share disorders with ADAM19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM19 Gene

Publications for ADAM19 Gene

  1. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PMID: 11162584) Wei P. … Sang Q.-X.A. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  2. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PMID: 10887142) Fritsche J. … Kreutz M. (Blood 2000) 3 4 22 64
  3. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PMID: 9806848) Hirohata S. … Apte S.S. (Genomics 1998) 2 3 22 64
  4. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PMID: 20010835) Hancock D.B. … London S.J. (Nat. Genet. 2010) 3 46 64
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for ADAM19 Gene

Sources for ADAM19 Gene

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