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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM19 Gene

protein-coding   GIFtS: 61
GCID: GC05M156836

ADAM metallopeptidase domain 19

(Previous name: a disintegrin and metalloproteinase domain 19 (meltrin...)
 Explore 12 diseases affiliated with
ADAM19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAM19    

Aliases
for ADAM19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 191 2     Disintegrin And Metalloproteinase Domain-Containing Protein 192
MLTNB1 2 3 5     Meltrin Beta2
A Disintegrin And Metalloproteinase Domain 19 (Meltrin Beta)1 2     Meltrin-Beta1
Metalloprotease And Disintegrin Dendritic Antigen Marker2 3     EC 3.4.24.-3
MADDAM2 3     Meltrin-Beta1
ADAM 192 3     EC 3.4.248

External Ids:    HGNC: 1971   Entrez Gene: 87282   Ensembl: ENSG000001350747   OMIM: 6036405   UniProtKB: Q9H0133   

Export aliases for ADAM19 gene to outside databases

Previous GC identifers: GC05M156953 GC05M157455 GC05M156839 GC05M156885 GC05M151992


Summaries
for ADAM19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM19:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell
differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal
physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix
interactions, and signal transduction. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May
be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)

Gene Wiki entry for ADAM19


Genomic Views
for ADAM19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM19 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   STAT5A   POU3F2   JunD   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM19 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

ADAM19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM19 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156836:  view genomic region     (about GC identifiers)

Start:
 156,822,542 bp from pter      End:
 157,002,783 bp from pter
Size:
 180,242 bases      Orientation:
 minus strand

Proteins
for ADAM19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 19 precursor  
Size: 955 amino acids; 104997 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with SH3PXD2A
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9BZL5 Q9UHP2
Alternative splicing: 2 isoforms:  Q9H013-1   Q9H013-2   

Explore the universe of human proteins at neXtProt for ADAM19: NX_Q9H013

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H013

    • 3 DME Specific Peptides for ADAM19 (Q9H013)
     MAHEMGH  GEECDCG  SGGVNMDHS 

    ADAM19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_150377.1  
    ENSEMBL proteins: 
     ENSP00000428376   ENSP00000431027   ENSP00000257527   ENSP00000428654   ENSP00000414088  
     ENSP00000377588  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ADAM19

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    ADAM19 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADAM19

    Protein Domains /
    Families
    for ADAM19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM19 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H013

    ProtoNet protein and cluster: Q9H013

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAM19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
    neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May
    be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
    Induction: By 1,25(OH)2VD3 in monocytes

         Genatlas biochemistry entry for ADAM19:
    a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly
    expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in
    osteoblast differentiation

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

    miRNA
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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM19 (see all 78):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-128 hsa-miR-30d hsa-miR-759 hsa-miR-30a hsa-miR-3148 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: ADAM19
    OriGene siRNA: ADAM19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM19

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0017124SH3 domain binding IEA--


    ADAM19 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADAM19:
     Decreased melanin production 

    Animal Models:
         Mouse knock-out Adam19tm1Asf for ADAM19
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adam19):
     cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  muscle 
     skeleton 

    ADAM19 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAM19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_ECM remodeling
    		Metalloproteases in connective tissue degradation0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADAM19
        Metalloproteases in connective tissue degradation




    ADAM19 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ADAM19 (Q9H0132, 3 ENSP000002575274) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI2Q9NYB92, 3, ENSP000002610174MINT-50919 MINT-50918 I2D: score=3 STRING: ENSP00000261017
    ESF1Q9H5012, 3, ENSP000002028164MINT-51038 I2D: score=1 STRING: ENSP00000202816
    UBCP0CG482, 3, ENSP000003448184MINT-51039 I2D: score=2 STRING: ENSP00000344818
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    SH3GL2Q999623, ENSP000003699814I2D: score=1 STRING: ENSP00000369981
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006509membrane protein ectodomain proteolysis IEA--
    GO:0007507heart development IEA--


    ADAM19 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM19
    Search CenterWatch for drugs/clinical trials and news about ADAM19 / ADA19 

    Transcripts
    for ADAM19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM19 gene (2 alternative transcripts): 
    NM_033274.3  NM_023038.3  

    Unigene Cluster for ADAM19:

    ADAM metallopeptidase domain 19
    Hs.483944  [show with all ESTs]
    Unigene Representative Sequence: NM_033274
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517951(uc003lww.2) ENST00000517374 ENST00000257527(uc003lwz.3)
    ENST00000517905(uc011ddr.1) ENST00000519752 ENST00000430702 ENST00000394020(uc003lwy.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM19
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM19 (see all 78):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-128 hsa-miR-30d hsa-miR-759 hsa-miR-30a hsa-miR-3148 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM19 (see all 4)
    OriGene shRNA RFP: ADAM19
    OriGene siRNA: ADAM19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM19
    Clone
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    GenScript: all cDNA clones in your preferred vector: ADAM19 (NM_033274)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM19

    Additional cDNA sequence: 

    AF134707.1 AF311317.1 AF326918.1 AK093535.1 AK308182.1 AL049415.1 BC024214.2 BC033132.1 
    Y13786.2 

    8 DOTS entries:

    DT.213222  DT.95170801  DT.86842185  DT.92424141  DT.40253624  DT.91879845  DT.95170800  DT.95339040 

    24/112 AceView cDNA sequences (see all 112):

    AI422731 BQ017560 AW195100 BE674636 AA937792 BU194499 BC024214 AA832347 
    BE502479 AI638530 AF311317 W00799 BQ775611 AA167288 BG057680 CN483705 
    N69991 AA167289 BC033132 AI681576 AA375767 BF059166 BU166620 BE389727 

    GeneLoc Exon Structure


    Expression
    for ADAM19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAM19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOutflow Tract CushionOutflow Tract Cushion CellsEndocardium, Neural Crest
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ADAM19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM19

    SOURCE GeneReport for Unigene cluster: Hs.483944

    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines

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    In Situ
    Assay Products:     
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    Orthologs
    for ADAM19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAM19 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Adam191 , 5 a disintegrin and metallopeptidase domain 19 (meltrin more1, 5 84.79(n)1
    84.06(a)1    		   11 (27.54 cM)5
    114921  NM_009616.31  NP_033746.11 
     460559925 
    chicken
    (Gallus gallus)    		 Aves ADAM191 ADAM metallopeptidase domain 19 65.8(n)
    62.03(a)    		   416244  NM_001195122.1  NP_001182051.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM196
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343205.1(2743008-2779098)
    African clawed frog
    (Xenopus laevis)    		 Amphibia U66003.12   -- 76.49(n)    U66003.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC057428.12   -- 70.98(n)   393610  BC057428.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0034961 AGAP003496-PA 47.81(n)
    38.3(a)    		   1270932  XM_309660.4  XP_309660.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea adm-13
    unc-711    		 Disintegrin3
    Protein UNC-711    		 30(a)3
    43.81(n)1
    33.11(a)1    		   III(12952834-12963248)3
    1767061  NM_067279.51  NP_499680.11 


    ENSEMBL Gene Tree for ADAM19 (if available)
    TreeFam Gene Tree for ADAM19 (if available) 

    Paralogs
    for ADAM19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM19 gene
    ADAM72  ADAM122  ADAM232  ADAM332  ADAM112  ADAM302  ADAM222  ADAM282  
    ADAM292  ADAM202  ADAM92  ADAM212  ADAM152  ADAM82  
    16 SIMAP similar genes for ADAM19 using alignment to 6 protein entries:     ADA19_HUMAN (see all proteins):
    ADAM9    ADAM12    ADAMDEC1    ADAM28    ADAM33    ADAM21
    ADAM23    ADAM7    ADAM20    ADAM22    ADAM15    ADAM30
    ADAM2    ADAM11    ADAM18    ADAM8

    ADAM19 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1853 NCBI SNPs in ADAM19 are shown (see all 1853)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1825719011,2
    		--156903947(+) GAGACC/GTGGGG 1 -- ds50010--------
    rs1881068161,2
    		--156904061(+) AAAACA/GTATCG 1 -- ds50010--------
    rs1909367561,2
    		--156904186(+) ACCATA/GAAGGC 1 -- ds50010--------
    rs1827495611,2
    		--156904241(+) TCCACA/GTCATG 1 -- ds50010--------
    rs111347641,2
    		C,F,H,--156904250(-) GATAGG/TATTCA 1 -- ds500113Minor allele frequency- T:0.03NA EU NS EA WA 1454
    rs114668261,2
    		C,F,H,--156904290(-) TTTATT/CGTGTG 1 -- ds500113Minor allele frequency- C:0.03NA EU NS EA WA 1402
    rs1890115311,2
    		--156904456(+) TTTTCC/TGTGAA 1 -- ut310--------
    rs1925460511,2
    		--156904542(+) GAGGAC/TGCGTT 1 -- ut310--------
    rs1482640601,2
    		--156904544(+) GGACGC/TGTTGG 1 -- ut310--------
    rs1843554701,2
    		--156904622(+) GGACCC/TTTCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM19 (156822542 - 157002783 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAM19
         2 CNVs: 3583 62447
    Human Gene Mutation Database (HGMD): ADAM19

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    Disorders / Diseases
    for ADAM19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM19 for disorders           About GeneDecksing

    OMIM gene information: 603640    OMIM disorders: --

    12 diseases for ADAM19:    About MalaCards
    pulmonary function    bipolar disorder    alzheimer's disease    ovarian cancer
    meningioma    pancreatic cancer    nephropathy    pancreatitis
    schizophrenia    leukemia    neuronitis    carcinoma

    3 Novoseek disease relationships for ADAM19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 28.3 1 16827870 (1)
    renal disease 11.4 8 16900093 (5), 16827870 (3)
    tumors 0 7 16772875 (3), 19601835 (1), 16827870 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADAM19 (8 documents)

    Export disorders for ADAM19 gene to outside databases

    Publications
    for ADAM19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM19 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with ADAM19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PubMed id 10887142)1, 2, 9 Fritsche J....Kreutz M. (2000)
    2. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PubMed id 9806848)1, 3, 9 Hirohata S....Apte S.S. (1998)
    3. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PubMed id 11162584)1, 2, 9 Wei P.... Sang Q.-X.A. (2001)
    4. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)1, 2 Abram C.L....Courtneidge S.A. (2003)
    5. Upregulation of ADAM19 in chronic allograft nephropathy. (PubMed id 16827870)1, 9 Melenhorst W.B....van Goor H. (2006)
    6. Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. (PubMed id 18714391)1, 9 Chan M.W....Lin H.J. (2008)
    7. Epigenetic regulation of the dendritic cell-marker gene ADAM19. (PubMed id 15896713)1, 9 Ehrnsperger A....Kreutz M. (2005)
    8. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PubMed id 12463424)1, 9 Huang L....Li C. (2002)
    9. Inhibitory antibodies against endopeptidase activity of human adamalysin 19. (PubMed id 11708814)1, 9 Zhao Y.G....Sang Q.X. (2001)
    10. The (pro)renin receptor is cleaved by ADAM19 in the G olgi leading to its secretion into extracellular space. (PubMed id 21270819)1 Yoshikawa A....Senbonmatsu T. (2011)

    External Searches for ADAM19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ADAM19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8728 HGNC: 197 AceView: ADAM19 Ensembl:ENSG00000135074 euGenes: HUgn8728
    ECgene: ADAM19 H-InvDB: ADAM19

    Other Databases showing ADAM19 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAM19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM19 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADAM19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM19 gene:
    Search GeneIP for patents involving ADAM19

    GeneCards and IP:
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