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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM19 Gene

protein-coding   GIFtS: 63
GCID: GC05M156836

ADAM Metallopeptidase Domain 19

(Previous name: a disintegrin and metalloproteinase domain 19 (meltrin beta))
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADAM Metallopeptidase Domain 191 2     Disintegrin And Metalloproteinase Domain-Containing Protein 192
MLTNB2 3 5     meltrin-beta2
A Disintegrin And Metalloproteinase Domain 19 (Meltrin Beta)1 2     Metalloprotease-Disintegrin Meltrin Beta2
Metalloprotease And Disintegrin Dendritic Antigen Marker2 3     EC 3.4.24.-3
MADDAM2 3     Meltrin-beta3
ADAM 192 3     EC 3.4.248
Meltrin Beta1     

External Ids:    HGNC: 1971   Entrez Gene: 87282   Ensembl: ENSG000001350747   OMIM: 6036405   UniProtKB: Q9H0133   

Export aliases for ADAM19 gene to outside databases

Previous GC identifers: GC05M156953 GC05M157455 GC05M156839 GC05M156885 GC05M151992


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM19 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic
cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal
physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal
transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases,
renal diseases, and Alzheimer's disease. (provided by RefSeq, May 2013)

GeneCards Summary for ADAM19 Gene: 
ADAM19 (ADAM metallopeptidase domain 19) is a protein-coding gene. Diseases associated with ADAM19 include meningioma, and pancreatic cancer, and among its related super-pathways are Cell adhesion ECM remodeling. GO annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin.
May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)

Gene Wiki entry for ADAM19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM19 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   STAT5A   POU3F2   JunD   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM19 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

ADAM19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM19 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156836:  view genomic region     (about GC identifiers)

Start:
156,822,542 bp from pter      End:
157,002,783 bp from pter
Size:
180,242 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 19 precursor  
Size: 955 amino acids; 104997 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with SH3PXD2A
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9BZL5 Q9UHP2
Alternative splicing: 2 isoforms:  Q9H013-1   Q9H013-2   

Explore the universe of human proteins at neXtProt for ADAM19: NX_Q9H013

Explore proteomics data for ADAM19 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H013

  • 3 DME Specific Peptides for ADAM19 (Q9H013)
     MAHEMGH  GEECDCG  SGGVNMDHS 

    ADAM19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAM19 Protein Expression
    REFSEQ proteins: NP_150377.1  
    ENSEMBL proteins: 
     ENSP00000428376   ENSP00000431027   ENSP00000257527   ENSP00000428654   ENSP00000414088  
     ENSP00000377588  

    Human Recombinant Protein Products for ADAM19: 
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    Cloud-Clone Corp. Proteins for ADAM19 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ADAM19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM19 
    ADAM

    5/8 InterPro protein domains (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H013

    ProtoNet protein and cluster: Q9H013

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA19_HUMAN, Q9H013
    Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
    neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin.
    May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
    Induction: By 1,25(OH)2VD3 in monocytes

         Genatlas biochemistry entry for ADAM19:
    a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly
    expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in
    osteoblast differentiation

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0017124SH3 domain binding IEA--
         
    ADAM19 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAM19:
     Decreased melanin production 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam19):
     cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  muscle 
     skeleton 

    ADAM19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam19tm1Asf for ADAM19

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM19 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAM19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADAM19
        Metalloproteases in connective tissue degradation




    ADAM19 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ADAM19 (Q9H0132, 3 ENSP000002575274) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI2Q9NYB92, 3, ENSP000002610174MINT-50919 MINT-50918 I2D: score=3 STRING: ENSP00000261017
    ESF1Q9H5012, 3, ENSP000002028164MINT-51038 I2D: score=1 STRING: ENSP00000202816
    UBCP0CG482, 3, ENSP000003448184MINT-51039 I2D: score=2 STRING: ENSP00000344818
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    SH3GL2Q999623, ENSP000003699814I2D: score=1 STRING: ENSP00000369981
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006509membrane protein ectodomain proteolysis IEA--
    GO:0007507heart development IEA--

    ADAM19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM19 (ADA19)

    Search CenterWatch for drugs/clinical trials and news about ADAM19 / ADA19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAM19 gene (2 alternative transcripts): 
    NM_033274.4  NM_023038.3  

    Unigene Cluster for ADAM19:

    ADAM metallopeptidase domain 19
    Hs.483944  [show with all ESTs]
    Unigene Representative Sequence: NM_033274
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517951(uc003lww.2) ENST00000517374 ENST00000257527(uc003lwz.3)
    ENST00000517905(uc011ddr.1) ENST00000519752 ENST00000430702 ENST00000394020(uc003lwy.3)


    miRNA
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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM19 (see all 78):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-128 hsa-miR-30d hsa-miR-759 hsa-miR-30a hsa-miR-3148 hsa-miR-92b
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    Additional mRNA sequence: 

    AF134707.1 AF311317.1 AF326918.1 AK093535.1 AK308182.1 AL049415.1 BC024214.2 BC033132.1 
    Y13786.2 

    9 DOTS entries:

    DT.213222  DT.95170801  DT.86842185  DT.92424141  DT.40253624  DT.91879845  DT.95170800  DT.95339040 
    DT.97861713 

    24/112 AceView cDNA sequences (see all 112):

    AA375767 AI681576 BU194499 BC033132 W00799 BU166620 AI422731 AA167288 
    BF059166 AA937792 BG057680 CN483705 BQ775611 BE502479 BE674636 BE389727 
    AI638530 BC024214 N69991 AA832347 AA167289 AF311317 BQ017560 AW195100 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM19 expression in normal human tissues (normalized intensities)      ADAM19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTTTTT
    ADAM19 Expression
    About this image


    ADAM19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Trigeminal Ganglion   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/urogenital sinus/primitive bladder   
     
     Smooth Muscle (Muscoskeletal System)
             Human umbilical Smooth Muscle (HUSM)   

    See ADAM19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM19

    SOURCE GeneReport for Unigene cluster: Hs.483944

    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAM19 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam191 , 5 a disintegrin and metallopeptidase domain 19 (meltrin more1, 5 84.79(n)1
    84.06(a)1
      11 (27.54 cM)5
    114921  NM_009616.31  NP_033746.11 
     460559925 
    chicken
    (Gallus gallus)
    Aves ADAM191 ADAM metallopeptidase domain 19 65.8(n)
    62.03(a)
      416244  NM_001195122.1  NP_001182051.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM196
    ADAM metallopeptidase domain 19
    64(a)
    1 ↔ 1
    GL343205.1(2737376-2809672)
    African clawed frog
    (Xenopus laevis)
    Amphibia U66003.12   -- 76.49(n)    U66003.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057428.12   -- 70.98(n)   393610  BC057428.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0034961 AGAP003496-PA 47.81(n)
    38.3(a)
      1270932  XM_309660.4  XP_309660.4 
    worm
    (Caenorhabditis elegans)
    Secernentea adm-13
    unc-711
    Disintegrin3
    Protein UNC-711
    30(a)3
    43.81(n)1
    33.11(a)1
      III(12952834-12963248)3
    1767061  NM_067279.51  NP_499680.11 


    ENSEMBL Gene Tree for ADAM19 (if available)
    TreeFam Gene Tree for ADAM19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM19 gene
    ADAM72  ADAM322  ADAM122  ADAM182  ADAM332  ADAM302  ADAM22  ADAM282  
    ADAM292  ADAM202  ADAM212  ADAM92  ADAM152  ADAM82  
    15 SIMAP similar genes for ADAM19 using alignment to 6 protein entries:     ADA19_HUMAN (see all proteins):
    ADAM9    ADAM12    ADAMDEC1    ADAM28    ADAM33    ADAM21
    ADAM23    ADAM7    ADAM20    ADAM22    ADAM15    ADAM30
    ADAM2    ADAM11    ADAM18

    ADAM19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2271 SNPs in ADAM19 are shown (see all 2271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0626704
    A pancreatic ductal adenocarcinoma sample4--see VAR_0626702 H Q mis40--------
    VAR_0361464
    A colorectal cancer sample4--see VAR_0361462 R Q mis40--------
    VAR_0361474
    A colorectal cancer sample4--see VAR_0361472 A T mis40--------
    rs1825719011,2
    --156903947(+) GAGACC/GTGGGG 1 -- ds50010--------
    rs1881068161,2
    --156904061(+) AAAACA/GTATCG 1 -- ds50010--------
    rs1909367561,2
    --156904186(+) ACCATA/GAAGGC 1 -- ds50010--------
    rs1827495611,2
    --156904241(+) TCCACA/GTCATG 1 -- ds50010--------
    rs111347641,2
    C,F,H--156904250(-) GATAGG/TATTCA 1 -- ds500113Minor allele frequency- T:0.03NA EU NS EA WA 1454
    rs114668261,2
    C,F,H--156904290(-) TTTATT/CGTGTG 1 -- ds500113Minor allele frequency- C:0.03NA EU NS EA WA 1402
    rs1890115311,2
    --156904456(+) TTTTCC/TGTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAM19 (156822542 - 157002783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADAM19:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997268CNV Deletion20482838
    esv6935CNV Loss19470904
    nsv5089CNV Loss18451855
    nsv883063CNV Loss21882294
    nsv830526CNV Loss17160897
    nsv462497CNV Loss19166990
    dgv1868e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ADAM19
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM19
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603640    OMIM disorders: --

    6 diseases for ADAM19:    About MalaCards
    meningioma    pancreatic cancer    alzheimer's disease    ovarian cancer
    pancreatitis    leukemia


    ADAM19 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for ADAM19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 28.3 1 16827870 (1)
    renal disease 11.4 8 16900093 (5), 16827870 (3)
    tumors 0 7 16772875 (3), 19601835 (1), 16827870 (1)

    Genetic Association Database (GAD): ADAM19
    Human Genome Epidemiology (HuGE) Navigator: ADAM19 (8 documents)

    Export disorders for ADAM19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM19 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with ADAM19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PubMed id 10887142)1, 2, 9 Fritsche J....Kreutz M. (2000)
    2. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PubMed id 9806848)1, 3, 9 Hirohata S....Apte S.S. (1998)
    3. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PubMed id 11162584)1, 2, 9 Wei P.... Sang Q.-X.A. (2001)
    4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    5. Meta-analyses of genome-wide association studies iden tify multiple loci associated with pulmonary function. (PubMed id 20010835)1, 4 Hancock D.B....London S.J. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)1, 4 Wang K.S....Aragam N. (2010)
    8. New sequence variants associated with bone mineral density. (PubMed id 19079262)1, 4 Styrkarsdottir U....Stefansson K. (2009)
    9. Upregulation of ADAM19 in chronic allograft nephropathy. (PubMed id 16827870)1, 9 Melenhorst W.B....van Goor H. (2006)
    10. Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. (PubMed id 18714391)1, 9 Chan M.W....Lin H.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8728 HGNC: 197 AceView: ADAM19 Ensembl:ENSG00000135074 euGenes: HUgn8728
    ECgene: ADAM19 H-InvDB: ADAM19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAM19 gene:
    Search GeneIP for patents involving ADAM19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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