ADAM18 Gene
protein-coding GIFtS: 47
GCID: GC08P039459
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ADAM metallopeptidase domain 18(Previous name: a disintegrin and metalloproteinase domain 18 )
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Aliases for ADAM18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 181 2 | | ADAM 182 3 | | ADAM271 2 | | TMDC III2 3 | | A Disintegrin And Metalloproteinase Domain 181 2 | | Disintegrin And Metalloproteinase Domain-Containing Protein 182 | | TMDCIII1 | | TMDC33 | | Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-RichProtein III2 3 | | |
Export aliases for ADAM18 gene to outside databasesPrevious GC identifers: GC08P038838 GC08P039501 GC08P039182 GC08P038983 GC08P039561 GC08P037975 |
Summaries for ADAM18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ADAM18: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety ofbiologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, andneurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010) UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7Function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a noncatalytic metalloprotease-like protein (By similarity) Gene Wiki entry for ADAM18
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Genomic Views for ADAM18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ADAM18 gene promoter: CUTL1 Evi-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM18
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM18 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p11.22ADAM18 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P039459: view genomic region
(about GC identifiers)
Start:
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39,442,008 bp from pter |
End:
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39,587,584 bp from pter |
Size:
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145,577 bases |
Orientation:
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plus strand |
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Proteins for ADAM18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 18 precursor Size: 739 amino acids; 82856 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2R9Y0 Q0VAI4 Q6IRW9 Q6UXJ9Alternative splicing: 3 isoforms: Q9Y3Q7-1 Q9Y3Q7-2 Q9Y3Q7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ADAM18: NX_Q9Y3Q7
Post-translational modifications:
The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3Q7 ADAM18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001177885.1 NP_055052.1 ENSEMBL proteins: ENSP00000429335 ENSP00000265707 ENSP00000369195 ENSP00000429908 ENSP00000428083 ENSP00000427730 ENSP00000444729 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ADAM18 for ontologies About GeneDecksing
ADAM18 Antibody Products: Assay Products for ADAM18: |
Protein
Domains / Families for ADAM18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM18 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9Y3Q7ProtoNet protein and cluster: Q9Y3Q7 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7Domain: A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrinreceptor and thus could mediate sperm/egg binding (By similarity)Similarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain |
Function for ADAM18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7Function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a noncatalytic metalloprotease-like protein (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM18 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADAM18 (NM_014237) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM18  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM18 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ADAM18 for ontologies About GeneDecksing
Animal Models: Mouse knock-out Adam18tm1Lex for ADAM18 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Adam18):
ADAM18 for phenotypes About GeneDecksing
|
Pathways & Interactions for ADAM18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM18
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for ADAM18 (ENSP000002657074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ADAM18 for ontologies About GeneDecksing
|
Drugs & Compounds for ADAM18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ADAM18 Search CenterWatch for drugs/clinical trials and news about ADAM18 / ADA18 
|
Transcripts for ADAM18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ADAM18 gene (2 alternative transcripts): NM_001190956.1 NM_014237.2 Unigene Cluster for ADAM18: ADAM metallopeptidase domain 18 Hs.127930 [show with all ESTs]Unigene Representative Sequence: NM_01423710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520001 ENST00000265707(uc003xni.3 uc010lww.3 uc010lwx.3) ENST00000379866 ENST00000520772(uc003xnh.3) ENST00000520087 ENST00000522198 ENST00000520559 ENST00000523755 ENST00000524117 ENST00000541111
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM18 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADAM18 (NM_014237) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM18  |
Additional cDNA sequence: AJ133004.1 AK225744.1 AK313961.1 AY358321.1 BC034624.1 BC070279.1 BC121045.1 BC121046.1 6 DOTS entries: DT.205231 DT.99932611 DT.97839168 DT.91667833 DT.91667835 DT.91667831 24/29 AceView cDNA sequences (see all 29): BC070279 AY358321 NM_014237 AJ133004 CD385213 BQ429723 BG184589 AI149619 BQ432655 BQ435891 BP371488 BG722982 AI073398 BI464271 BE866717 BQ428666 AA724715 AA906452 BU182593 AA978174 BC034624 BG201756 AA906424 AA969255 GeneLoc Exon Structure
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Expression for ADAM18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM18 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAAGGAATTT
About this image See ADAM18 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ADAM18
SOURCE GeneReport for Unigene cluster: Hs.127930 UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7Tissue specificity: Expressed specifically in testis SABiosciences Custom PCR Arrays for ADAM18
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM18 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM18 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM18 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM18 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM18 |
Orthologs for ADAM18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ADAM18 gene from 2/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ADAM26 |
Uncharacterized protein |
37(a) |
1 → many |
22(2487128-2497590) |
lizard (Anolis carolinensis) |
Reptilia |
ADAM26 |
-- |
40(a) |
1 → many |
GL343418.1(598118-621755) |
ENSEMBL Gene Tree for ADAM18 (if available) TreeFam Gene Tree for ADAM18 (if available)  |
Paralogs for ADAM18 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ADAM18 gene
- ADAM322 ADAM22 ADAMDEC12
14 SIMAP similar genes for ADAM18 using alignment to 5 protein entries: ADA18_HUMAN (see all proteins):ADAM32 ADAM22 ADAM9 ADAM2 ADAM21 ADAM30 ADAM23 ADAM28 ADAM29 ADAM7 ADAM12 ADAM19 ADAM20 ADAM33
ADAM18 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ADAM18 PGOHUM00000250658 PGOHUM00000263194 PGOHUM00000250025 PGOHUM00000249984
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Genomic Variants for ADAM18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ADAM18 (39442008 - 39587584 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ADAM18 3 CNVs: 3728 2749 7684  | 1 SABiosciences Cancer Mutation PCR Assay for ADAM18: | Cosmic Id | AA Change |
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| 141231 | p.P170S |
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|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM18 |
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Disorders
/ Diseases for ADAM18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAM18 for disorders About GeneDecksing
2 diseases for ADAM18: About MalaCardsepididymitis melanoma Human Genome Epidemiology (HuGE) Navigator: ADAM18 (1 document) Export disorders for ADAM18 gene to outside databases
|
Publications for ADAM18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM18 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with ADAM18) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human tMDC III: a sperm protein with a potential role in oocyte recognition. (PubMed id 12200459)1, 3, 9 Frayne J....Hall L. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1 Lingappa J.R....Goldstein D. (2011)
- Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PubMed id 21618342)2 Wei X.... Samuels Y. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ADAM18 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ADAM18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ADAM18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAM18 gene: Search GeneIP for patents involving ADAM18
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ADAM18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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variant library, vector shuttling | | OriGene Custom Antibody Services for ADAM18 | | OriGene Custom Protein Services for ADAM18 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM18 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM18 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM18 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM18 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM18 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM18 |
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 | | ADAM18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM18 |
|  |  |  | | | Search ThermoFisher Antibodies for ADAM18 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM18 |
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