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ADAM18 Gene

protein-coding   GIFtS: 51
GCID: GC08P039459

ADAM Metallopeptidase Domain 18

(Previous name: a disintegrin and metalloproteinase domain 18)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 181 2     Putative ADAM18 Gene Product2
A Disintegrin And Metalloproteinase Domain 181 2     tMDCIII2
Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich
Protein III2 3
     TMDC33
ADAM272     ADAM 183
Disintegrin And Metalloproteinase Domain-Containing Protein 182     TMDC III3

External Ids:    HGNC: 1961   Entrez Gene: 87492   Ensembl: ENSG000001686197   UniProtKB: Q9Y3Q73   

Export aliases for ADAM18 gene to outside databases

Previous GC identifers: GC08P038838 GC08P039501 GC08P039182 GC08P038983 GC08P039561 GC08P037975


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM18 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for ADAM18 Gene:
ADAM18 (ADAM metallopeptidase domain 18) is a protein-coding gene. Diseases associated with ADAM18 include epididymitis, and hiv-1. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7
Function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non
catalytic metalloprotease-like protein (By similarity)

Gene Wiki entry for ADAM18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NT_187577.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM18 gene promoter:
         CUTL1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM18 promoter sequence
   Search Chromatin IP Primers for ADAM18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.22

ADAM18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM18 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P039459:  view genomic region     (about GC identifiers)

Start:
39,442,008 bp from pter      End:
39,587,583 bp from pter
Size:
145,576 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 18 precursor  
Size: 739 amino acids; 82856 Da
Secondary accessions: B2R9Y0 Q0VAI4 Q6IRW9 Q6UXJ9
Alternative splicing: 3 isoforms:  Q9Y3Q7-1   Q9Y3Q7-2   Q9Y3Q7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM18: NX_Q9Y3Q7

Explore proteomics data for ADAM18 at MOPED

Post-translational modifications: 

  • The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa
    (By similarity)1
  • Glycosylation2 at Asn36, Asn76, Asn122, Asn149, Asn156, Asn177, Asn294, Asn359, Asn465, Asn561,
                                 Asn611, Asn625
  • Modification sites at PhosphoSitePlus

  • See ADAM18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177885.1  NP_055052.1  

    ENSEMBL proteins: 
     ENSP00000429335   ENSP00000265707   ENSP00000369195   ENSP00000429908   ENSP00000428083  
     ENSP00000444729  

    ADAM18 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM18
    ADAM

    Selected InterPro protein domains (see all 6):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q7

    ProtoNet protein and cluster: Q9Y3Q7

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7
    Domain: A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding (By similarity)
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA18_HUMAN, Q9Y3Q7
    Function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non
    catalytic metalloprotease-like protein (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity TAS10395895
    GO:0008270zinc ion binding IEA--
         
    ADAM18 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adam18):
     behavior/neurological 

    ADAM18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam18tm1Lex for ADAM18

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM18
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    miRNA
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    miRTarBase miRNAs that target ADAM18:
    hsa-mir-26b-5p (MIRT029408)

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    1 qRT-PCR Assays for microRNA that regulate ADAM18:
    hsa-miR-548n
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA18_HUMAN, Q9Y3Q7: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane TAS10395895
    GO:0016021integral component of membrane IEA--

    ADAM18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM18
    Interactions:

        Search GeneGlobe Interaction Network for ADAM18

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ADAM18 (ENSP000002657074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1ENSP000003457314STRING: ENSP00000345731
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    ADAM18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM18 (ADA18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM18 gene (2 alternative transcripts): 
    NM_001190956.1  NM_014237.2  

    Unigene Cluster for ADAM18:

    ADAM metallopeptidase domain 18
    Hs.127930  [show with all ESTs]
    Unigene Representative Sequence: NM_014237
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520001 ENST00000265707(uc003xni.3 uc010lww.3 uc010lwx.3)
    ENST00000379866 ENST00000520772(uc003xnh.3) ENST00000520087 ENST00000520559
    ENST00000523755 ENST00000524117 ENST00000541111
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADAM18:
    hsa-miR-548n
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      QuantiTect SYBR Green Assays in human, mouse, rat ADAM18
      QuantiFast Probe-based Assays in human, mouse, rat ADAM18

    Additional mRNA sequence: 

    AJ133004.1 AK225744.1 AK313961.1 AY358321.1 BC034624.1 BC070279.1 BC121045.1 BC121046.1 

    6 DOTS entries:

    DT.205231  DT.99932611  DT.97839168  DT.91667833  DT.91667835  DT.91667831 

    Selected AceView cDNA sequences (see all 29):

    AJ133004 BC070279 NM_014237 AY358321 BG722982 BQ428666 BE866717 BP371488 
    AA906452 AA724715 BC034624 AA978174 BQ429723 BG201756 AI149619 BI464271 
    BQ432655 AI073398 BQ435891 BU182593 BG184589 CD385213 AA906424 AA969255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGAATTT
    ADAM18 Expression
    About this image


    ADAM18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Testis (Reproductive System)
    ADAM18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127930

    UniProtKB/Swiss-Prot: ADA18_HUMAN, Q9Y3Q7
    Tissue specificity: Expressed specifically in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ADAM18 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam181 , 5 a disintegrin and metallopeptidase domain 181, 5 74.39(n)1
    63.6(a)1
      8 (12.82 cM)5
    135241  NM_010084.21  NP_034214.21 
     246022465 


    ENSEMBL Gene Tree for ADAM18 (if available)
    TreeFam Gene Tree for ADAM18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM18 gene
    ADAM322  ADAM232  ADAM112  ADAM222  ADAM22  ADAMDEC12  
    11 SIMAP similar genes for ADAM18 using alignment to 4 protein entries:     ADA18_HUMAN (see all proteins):
    ADAM32    ADAM9    ADAM2    ADAM21    ADAM30    ADAM29
    ADAM12    ADAM19    ADAM20    ADAM28    ADAM7

    ADAM18 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ADAM18
    PGOHUM00000250658 PGOHUM00000263194 PGOHUM00000250025 PGOHUM00000249984


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM18 (see all 2919)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663124
    A cutaneous metastatic melanoma sample4--see VAR_0663122 P S mis40--------
    VAR_0663144
    A cutaneous metastatic melanoma sample4--see VAR_0663142 M I mis40--------
    VAR_0663164
    A cutaneous metastatic melanoma sample4--see VAR_0663162 S L mis40--------
    VAR_0663154
    A cutaneous metastatic melanoma sample4--see VAR_0663152 M K mis40--------
    VAR_0663134
    A cutaneous metastatic melanoma sample4--see VAR_0663132 V G mis40--------
    rs1816611851,2
    --39440123(+) CAATAA/GTAATT 2 -- us2k10--------
    rs1485125461,2
    --39440163(+) CTTAGC/TAGATC 2 -- us2k10--------
    rs1427557671,2
    --39440189(+) ATCAGC/TCTTAT 2 -- us2k10--------
    rs1867921581,2
    C--39440247(+) GCCCAC/TGCTGG 2 -- us2k10--------
    rs802319321,2
    C--39440303(+) GTTCAG/AGCAAT 2 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ADAM18 (39442008 - 39587583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAM18 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2225914CNV Deletion18987734
    esv2660839CNV Deletion23128226
    esv2736903CNV Deletion23290073
    esv271607CNV Insertion20981092
    dgv7781n71CNV Loss21882294
    dgv7782n71CNV Loss21882294
    nsv890837CNV Loss21882294
    nsv890835CNV Loss21882294
    dgv7783n71CNV Loss21882294
    nsv890831CNV Loss21882294

    1 Site Specific Mutation Identification with PCR Assay for ADAM18:
    Cosmic IdAA Change
    141231p.P170S
    SeqTarget long-range PCR primers for resequencing ADAM18
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ADAM18:    
    About MalaCards
    epididymitis    hiv-1    melanoma


    ADAM18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAM18
    Human Genome Epidemiology (HuGE) Navigator: ADAM18 (1 document)

    Export disorders for ADAM18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM18 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ADAM18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tMDC III: a sperm protein with a potential role in oocyte recognition. (PubMed id 12200459)1, 3, 9 Frayne J....Hall L. (Mol. Hum. Reprod. 2002)
    2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PubMed id 21618342)2 Wei X.... Samuels Y. (Hum. Mutat. 2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8749 HGNC: 196 AceView: ADAM18 Ensembl:ENSG00000168619 euGenes: HUgn8749
    ECgene: ADAM18 H-InvDB: ADAM18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM18 gene:
    Search GeneIP for patents involving ADAM18

    GeneCards and IP:
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