Aliases for ADAM17 Gene
External Ids for ADAM17 Gene
Previous Symbols for ADAM17 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAM17 Gene
ADAM17 (ADAM Metallopeptidase Domain 17) is a Protein Coding gene. Diseases associated with ADAM17 include inflammatory skin and bowel disease, neonatal, 1 and neonatal inflammatory skin and bowel disease. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM10.
UniProtKB/Swiss-Prot for ADAM17 Gene
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.