Aliases for ADAM17 Gene
External Ids for ADAM17 Gene
Previous HGNC Symbols for ADAM17 Gene
Previous GeneCards Identifiers for ADAM17 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAM17 Gene
ADAM17 (ADAM Metallopeptidase Domain 17) is a Protein Coding gene. Diseases associated with ADAM17 include inflammatory skin and bowel disease, neonatal, 1 and neonatal inflammatory skin and bowel disease. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM10.
UniProtKB/Swiss-Prot for ADAM17 Gene
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.