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ADAM17 Gene

protein-coding   GIFtS: 72
GCID: GC02M009628

ADAM Metallopeptidase Domain 17

(Previous names: tumor necrosis factor, alpha, converting enzyme)
(Previous symbol: TACE)
  See ADAM17-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

ADAM Metallopeptidase Domain 171 2     ADAM182
TACE1 2 3 5     CD156B2
Tumor Necrosis Factor, Alpha, Converting Enzyme1 2     ADAM Metallopeptidase Domain 182
Snake Venom-Like Protease2 3     Disintegrin And Metalloproteinase Domain-Containing Protein 172
CSVP2 3     TNF-Alpha Converting Enzyme2
TNF-Alpha Convertase2 3     ADAM 173
EC 8     CD156b Antigen3
NISBD2 5     TNF-Alpha-Converting Enzyme3

External Ids:    HGNC: 1951   Entrez Gene: 68682   Ensembl: ENSG000001516947   OMIM: 6036395   UniProtKB: P785363   

Export aliases for ADAM17 gene to outside databases

Previous GC identifiers: GC02M009412 GC02M009680 GC02M009651 GC02M009580

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM17 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha
converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of
the Notch signaling pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM17 Gene:
ADAM17 (ADAM metallopeptidase domain 17) is a protein-coding gene. Diseases associated with ADAM17 include inflammatory skin and bowel disease, neonatal, 1, and heterotaxy. GO annotations related to this gene include integrin binding and SH3 domain binding. An important paralog of this gene is ADAM10.

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55
TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid
precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the
membrane-associated intermediate fragment called Notch extracellular truncation (NEXT)

Gene Wiki entry for ADAM17 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM17 gene promoter:
         Bach1   Elk-1   AML1a   HOXA3   IRF-1   c-Ets-1   Nkx6-1   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM17 promoter sequence
   Search Chromatin IP Primers for ADAM17

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ADAM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM17 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009628:  view genomic region     (about GC identifiers)

9,628,615 bp from pter      End:
9,695,921 bp from pter
67,307 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 17 precursor  
Size: 824 amino acids; 93021 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with MAD2L1, MAPK14 and MUC1
Selected PDB 3D structures from and Proteopedia for ADAM17 (see all 23):
1BKC (3D)        1ZXC (3D)        2A8H (3D)        2DDF (3D)        2FV5 (3D)        2FV9 (3D)    
Secondary accessions: O60226
Alternative splicing: 2 isoforms:  P78536-1   P78536-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM17: NX_P78536

Explore proteomics data for ADAM17 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819
    but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated
    ectodomain shedding1
  • Ubiquitination2 at Lys728
  • Glycosylation2 at Asn103, Asn157, Asn174, Asn264, Asn452, Asn498, Asn539, Asn551, Asn594
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ADAM17 (P78536)

    See ADAM17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003174.3  
    ENSEMBL proteins: 
     ENSP00000309968   ENSP00000418728  
    Reactome Protein details: P78536

    ADAM17 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADAM17 (TACE/ADAM17)
    Enzo Life Sciences proteins for ADAM17
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAM17
    GenScript Custom Purified and Recombinant Proteins Services for ADAM17
    Novus Biologicals ADAM17 Proteins
    Sino Biological Recombinant Protein for ADAM17
    Sino Biological Cell Lysate for ADAM17
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM17

    Search eBioscience for Proteins for ADAM17 

    antibodies-online proteins for ADAM17 (10 products) 

    antibodies-online peptides for ADAM17

    Search GeneTex for Proteins for ADAM17 

    ADAM17 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM17
    R&D Systems Antibodies for ADAM17 (TACE/ADAM17)
    Cell Signaling Technology (CST) Antibodies for ADAM17  (TACE)
    OriGene Antibodies for ADAM17
    OriGene Custom Antibody Services for ADAM17
    Novus Biologicals ADAM17 Antibodies
    Abcam antibodies for ADAM17
    Cloud-Clone Corp. Antibodies for ADAM17
    ThermoFisher Antibody for ADAM17
    antibodies-online antibodies for ADAM17 (173 products) 

    GeneTex Antibodies for ADAM17:  
                        ADAM17 Antibodies

    ADAM17 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM17
    R&D Systems ELISAs for ADAM17 (TACE/ADAM17)         (see all)
    GenScript Custom Assay Services for ADAM17
    Enzo Life Sciences assays for ADAM17
    Cloud-Clone Corp. ELISAs for ADAM17
    Cloud-Clone Corp. CLIAs for ADAM17
    Search eBioscience for ELISAs for ADAM17 
    antibodies-online kits for ADAM17 (22 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    CD: CD molecules
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM17

    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry P78536

    ProtoNet protein and cluster: P78536

    2 Blocks protein domains:
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Domain: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for
    the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain

    Find genes that share domains with ADAM17           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA17_HUMAN, P78536
    Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
    proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
    several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55
    TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid
    precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the
    membrane-associated intermediate fragment called Notch extracellular truncation (NEXT)
    Catalytic activity: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in the
    membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other
    membrane-anchored, cell-surface proteins to 'shed' the extracellular domains
    Induction: In arthritis-affected cartilage

         Genatlas biochemistry entry for ADAM17:
    a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed in
    somatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP

         Enzyme Number (IUBMB): EC 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity TAS--
    GO:0005112Notch binding IDA--
    GO:0005138interleukin-6 receptor binding IPI16034137
    GO:0005178integrin binding IPI14970227
    GO:0005515protein binding IPI10527948
    Find genes that share ontologies with ADAM17           About GenesLikeMe

         2 GenomeRNAi human phenotypes for ADAM17:
     Increased viability after born  Stronger migration 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Adam17) (see all 20):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with ADAM17           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADAM17: Adam17tm1.1Bbl Adam17tm1Imx Adam17tm1.2Rain

       genOway: Develop your customized and physiologically relevant rodent model for ADAM17

        Taconic Biosciences Mouse Models for ADAM17:  
                        TF2248 - Adam17

    CRISPR Knockouts: 
       Browse OriGene CRISPR knockouts

    miRTarBase miRNAs that target ADAM17:
    hsa-mir-145-5p (MIRT007275), hsa-mir-122-5p (MIRT003112)

    Block miRNA regulation of human, mouse, rat ADAM17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAM17 (see all 17):
    hsa-miR-140-3p hsa-miR-224 hsa-miR-148b hsa-miR-520d-5p hsa-miR-634 hsa-miR-767-5p hsa-miR-512-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidADAM17 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for ADAM17
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM17

    OriGene clones in human, mouse for ADAM17 (see all 6)
    OriGene ORF clones in mouse, rat for ADAM17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183)
    Sino Biological Human cDNA Clone for ADAM17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17
    Addgene plasmids for ADAM17 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for ADAM17
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADAM17 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    ADA17_HUMAN, P78536: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    plasma membrane4
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA17786981
    GO:0005911colocalizes with cell-cell junction IDA14970227
    GO:0005925colocalizes with focal adhesion IDA14970227

    Find genes that share ontologies with ADAM17           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for ADAM17 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    Notch Signaling0.30
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    4Signaling by FGFR
    Signaling by EGFR0.83
    Signalling by NGF0.71
    Signaling by EGFR in Cancer0.82
    5Death Receptor Signalling
    Death Receptor Signalling0.71
    Extrinsic Pathway for Apoptosis0.00
    TNF signaling0.00

    Find genes that share SuperPaths with ADAM17           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for ADAM17
        A-beta Plaque Formation & APP Metabolism
    Notch Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADAM17 (see all 6)
        Notch Signaling
    Inhibition of Matrix Metalloproteinases
    Molecular Mechanisms of Cancer
    Alzheimers Disease Pathway
    Presenilin-Mediated Signaling

    2 Cell Signaling Technology (CST) Pathways for ADAM17
        Wnt / Hedgehog / Notch

    5 GeneGo (Thomson Reuters) Pathways for ADAM17
        Immune response IL-6 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Notch Signaling Pathway
    Development MAG-dependent inhibition of neurite outgrowth

    Selected BioSystems Pathways for ADAM17 (see all 7)
        Notch Signaling Pathway
    BDNF signaling pathway
    Delta-Notch Signaling Pathway
    Alzheimers Disease
    ErbB4 signaling events

    1 Sino Biological Pathway for ADAM17
        Notch Signaling Pathway

    Selected Reactome Pathways for ADAM17 (see all 11)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Regulated proteolysis of p75NTR
    Collagen degradation
    TNF signaling
    Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

    3 Kegg Pathways  (Kegg details for ADAM17):
        Notch signaling pathway
    Alzheimer's disease
    Epithelial cell signaling in Helicobacter pylori infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAM17: 
              Endothelial Cell Biology in human mouse rat
              Multiple Sclerosis in human mouse rat
              Liver Cancer in human mouse rat
              Notch Signaling Pathway in human mouse rat


        GeneGlobe Interaction Network for ADAM17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADAM17 (P785361, 2, 3 ENSP000003099684) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129591, 2, 3, ENSP000003457314EBI-78188,EBI-357481 MINT-1901891 MINT-1901801 MINT-1901824 MINT-1901856 MINT-1901710 MINT-1901743 MINT-1901775 I2D: score=4 STRING: ENSP00000345731
    PTPN3P260452, 3, ENSP000002625394MINT-58311 MINT-58317 I2D: score=3 STRING: ENSP00000262539
    PDIA3P301012, 3MINT-4301309 I2D: score=1 
    TNFP013753, ENSP000003986984I2D: score=2 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA18276953
    GO:0001934positive regulation of protein phosphorylation IMP18625725
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002467germinal center formation ISS10433800
    GO:0002690positive regulation of leukocyte chemotaxis IC16034137

    Find genes that share ontologies with ADAM17           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM17 (ADA17)

    8 DrugBank Compounds for ADAM17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid-- --target--10592235
    (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL-- --target--10592235
    3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol-- --target--10592235
    N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan-- --target--10592235
    methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for ADAM17 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adamalysin 84.6 3 12621058 (1), 10419777 (1)
    tapi 78.5 4 11106509 (1), 11156944 (1)
    hydroxamate 76.3 10 17368021 (1), 15284022 (1), 12723945 (1), 15128827 (1) (see all 7)
    (4-aminophenyl)mercuric acetate 70.7 2 18239612 (1), 15182369 (1)
    batimastat 70.4 4 15319441 (1), 9684866 (1), 10971741 (1), 12226103 (1)
    marimastat 58.1 4 10579851 (3), 12384559 (1)
    phorbol 50.3 3 10799547 (1), 15142990 (1), 19535569 (1)
    ag 1478 46.3 1 15319441 (1)
    phorbol-12-myristate 45.5 3 17942404 (1)
    zinc 40.1 24 15102849 (4), 15100227 (3), 10521439 (1), 17368021 (1) (see all 12)

    Find genes that share compounds with ADAM17           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for ADAM17 gene: 

    Unigene Cluster for ADAM17:

    ADAM metallopeptidase domain 17
    Hs.404914  [show with all ESTs]
    Unigene Representative Sequence: NM_003183
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310823(uc002qzu.3 uc010ewy.3 uc010ewz.3) ENST00000497134(uc010exa.3 uc010exb.1)
    Block miRNA regulation of human, mouse, rat ADAM17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAM17 (see all 17):
    hsa-miR-140-3p hsa-miR-224 hsa-miR-148b hsa-miR-520d-5p hsa-miR-634 hsa-miR-767-5p hsa-miR-512-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidADAM17 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for ADAM17
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM17
    OriGene clones in human, mouse for ADAM17 (see all 6)
    OriGene ORF clones in mouse, rat for ADAM17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17
    Addgene plasmids for ADAM17 
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM17
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM17
      QuantiFast Probe-based Assays in human, mouse, rat ADAM17

    Additional mRNA sequence: 

    AK289829.1 AY422721.1 BC062687.1 BC136783.1 BC146658.1 GQ402545.1 U69611.1 U69612.1 
    U86755.1 U92649.1 

    11 DOTS entries:

    DT.97840889  DT.101978379  DT.75154588  DT.91723298  DT.100737460  DT.91868817  DT.86857558  DT.100671075 
    DT.121006903  DT.121006944  DT.95089565 

    Selected AceView cDNA sequences (see all 88):

    AI141532 AI741293 AI919444 AI797833 AW057613 BF059089 AA827074 BU734977 
    AI141804 AA933982 AI075423 BM989580 AA910834 AW627690 AI095477 AI911263 
    N27387 CB159093 BM827395 NM_003183 CB068513 AY422721 BE645266 CA439922 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                      -                                                                                                         
    SP2:                                                                                      -                                                         

    ECgene alternative splicing isoforms for ADAM17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAM17 Expression
    About this image

    ADAM17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     Bone (Muscoskeletal System)
             Bone Marrow
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    ADAM17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404914

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle,
    pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAM17: 
              Endothelial Cell Biology in human mouse rat
              Multiple Sclerosis in human mouse rat
              Liver Cancer in human mouse rat
              Notch Signaling Pathway in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for ADAM17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM17
    QuantiTect SYBR Green Assays in human, mouse, rat ADAM17
    QuantiFast Probe-based Assays in human, mouse, rat ADAM17
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAM17 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Adam171 , 5 a disintegrin and metallopeptidase domain 171, 5 88.07(n)1
      12 (8.30 cM)5
    114911  NM_009615.61  NP_033745.41 
    (Gallus gallus)
    Aves ADAM171 ADAM metallopeptidase domain 17 74.16(n)
      421931  NM_001008682.1  NP_001008682.1 
    (Anolis carolinensis)
    Reptilia ADAM176
    ADAM metallopeptidase domain 17
    1 ↔ 1
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adam171 ADAM metallopeptidase domain 17 68.62(n)
      100492947  NM_001195230.1  NP_001182159.1 
    (Danio rerio)
    Actinopterygii wufc20b012 wufc20b01 75.1(n)   324142  BC057410.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79083
    proteolysis and peptidolysis
    435581  NM_170455.31  NP_733334.11 
    (Caenorhabditis elegans)
    Secernentea adm-41 , 3 metalloprotease3
    1810411  NM_076917.31  NP_509318.11 

    ENSEMBL Gene Tree for ADAM17 (if available)
    TreeFam Gene Tree for ADAM17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for ADAM17 gene
    1 SIMAP similar gene for ADAM17 using alignment to 8 protein entries:     ADA17_HUMAN (see all proteins):

    Find genes that share paralogs with ADAM17           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for ADAM17 (see all 1397)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 2 posSequence#AA
    --9601091(+) TAATTC/TAAATA 1 -- ds50010--------
    --9601136(+) TATCAA/CGTCTT 1 -- ds50010--------
    --9601153(+) ACAGCC/TCCCAA 1 -- ds50010--------
    --9601183(+) TCTATA/CTCCTG 1 -- ds50010--------
    --9601221(+) TTTTT-/TTGTTTGT 1 -- cds10--------
    C--9601234(+) TGTTG-/TTCTTGTT 1 -- cds10--------
    --9601234(+) TTGTTC/GTTGTT 1 -- ds50010--------
    C--9601236(+) TTGTT-/CTTGTTAA 1 -- cds10--------
    --9601248(+) AAATAC/TCTCAC 1 -- ds50010--------
    C--9601263(+) TTATTC/TAATAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADAM17 (9628615 - 9695921 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADAM17: --
    Human Gene Mutation Database (HGMD): ADAM17
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 603639   
    OMIM disorders: 614328  
    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
  • Neonatal inflammatory skin and bowel disease (NISBD) [MIM:614328]: A disorder characterized by
    inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral
    and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules.
    Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal
    infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for ADAM17:    
    About MalaCards
    inflammatory skin and bowel disease, neonatal, 1    heterotaxy    dilated cardiomyopathy

    Find genes that share disorders with ADAM17           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADAM17 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 79.5 222 15206946 (4), 10521439 (2), 15075334 (2), 16737974 (2) (see all 99)
    tumors 63.1 208 15206946 (3), 17822026 (3), 17227756 (3), 10521439 (2) (see all 99)
    rheumatoid arthritis 43.1 8 14579524 (1), 14718605 (1), 12670535 (1), 20303413 (1) (see all 7)
    inflammation 34.7 14 12973924 (1), 19581416 (1), 20331435 (1), 17822026 (1) (see all 9)
    alzheimers disease 28.3 8 19234765 (3), 11032903 (2)
    arthritis 24.9 5 18471442 (1), 12463167 (1), 15859325 (1), 17376651 (1) (see all 5)
    senile plaques 23.4 1 11536196 (1)
    multiple sclerosis 15.9 5 16511637 (2), 19324423 (1), 12474981 (1), 15859325 (1)
    cancer 11.6 32 19843672 (5), 19408347 (2), 15309730 (1), 15197174 (1) (see all 10)
    osteoarthritis 5.26 6 9574564 (1), 14579524 (1), 10419777 (1), 11508576 (1)

    Genetic Association Database (GAD): ADAM17
    Human Genome Epidemiology (HuGE) Navigator: ADAM17 (16 documents)

    Export disorders for ADAM17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM17 gene, integrated from 10 sources (see all 507) (see top 10):
    (articles sorted by number of sources associating them with ADAM17)

    1. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PubMed id 9574564)1, 2, 3, 9 Patel I.R.... Amin A.R. (J. Immunol. 1998)
    2. A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PubMed id 9034190)1, 2, 3 Black R.A.... Cerretti D.P. (Nature 1997)
    3. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. (PubMed id 18600307)1, 4, 9 Morange P.E....Tiret L. (J. Mol. Med. 2008)
    4. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PubMed id 12621058)1, 2, 9 Fan H.... Derynck R. (J. Biol. Chem. 2003)
    5. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PubMed id 9034191)1, 2, 9 Moss M.L.... Becherer J.D. (Nature 1997)
    6. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (Mol. Cell 2010)
    7. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. (PubMed id 9520379)1, 2, 9 Maskos K.... Bode W. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. Inflammatory skin and bowel disease linked to ADAM17 deletion. (PubMed id 22010916)1, 2 Blaydon D.C.... Kelsell D.P. (N. Engl. J. Med. 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. (PubMed id 20300049)1, 4 Potter C....Barton A. (Pharmacogenet. Genomics 2010)
    11. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    12. ADAM17_i33708A&gt;G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study. (PubMed id 19819120)1, 4 Junyent M....OrdovA!s J.M. (Nutr Metab Cardiovasc Dis 2010)
    13. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    14. The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer's disease in a Northern Chinese Han population. (PubMed id 20627730)1, 4 Wang M....Jia J. (J Clin Neurosci 2010)
    15. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    16. Polymorphisms in the tumor necrosis factor/lipopolysaccharides pathway in Crohn disease in the Jewish Ashkenazi population. (PubMed id 18493210)1, 4 Silbermintz A....Silver J. (J. Pediatr. Gastroenterol. Nutr. 2008)
    17. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    18. Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. (PubMed id 18442814)1, 4 SpinarovA! L....VA-tovec J. (Exp. Mol. Pathol. 2008)
    19. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    20. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    21. Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. (PubMed id 12441351)1, 2 Thathiah A.... Carson D.D. (J. Biol. Chem. 2003)
    22. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. (PubMed id 12058067)1, 2 Diaz-Rodriguez E....Pandiella A. (Mol. Biol. Cell 2002)
    23. ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability? (PubMed id 19535569)1, 9 Melenhorst W.B....van Goor H. (Am. J. Physiol. Renal Physiol. 2009)
    24. Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer. (PubMed id 19843672)1, 9 Ge L....Vujanovic N.L. (amp 2009)
    25. Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia. (PubMed id 19299578)1, 9 Cesaro A....Hofman P.M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    26. Tumor necrosis factor-alpha-converting enzyme as a potential mediator of the influence of smoking on the response to treatment with narrowband ultraviolet B in psoriasis patients. (PubMed id 20070837)1, 9 Serwin A.B....Chodynicka B. (amp 2010)
    27. ADAM17 mRNA expression and pathological features of hepatocellular carcinoma. (PubMed id 15309730)1, 9 Ding X....Lu W.Q. (World J. Gastroenterol. 2004)
    28. TACE inhibition amplifies TNF-alpha-mediated colonic epithelial barrier disruption. (PubMed id 19082505)1, 9 FrAcour T....Masson D. (Int. J. Mol. Med. 2009)
    29. Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. (PubMed id 18383040)1, 9 Brennan F.M....Takata M. (Eur. J. Immunol. 2008)
    30. Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation. (PubMed id 18276953)1, 9 Hung T.H....Hsieh T.T. (Reprod Sci 2008)
    31. ADAM-17 expression in breast cancer correlates with variables of tumor progression. (PubMed id 17438092)1, 9 McGowan P.M....Duffy M.J. (Clin. Cancer Res. 2007)
    32. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity. (PubMed id 15102849)1, 9 Solomon A....Sagi I. (J. Biol. Chem. 2004)
    33. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. (PubMed id 19633828)1, 9 Monroy A....Folli F. (Diabetologia 2009)
    34. Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors. (PubMed id 17227756)1, 9 Santiago-Josefat B....Arribas J. (J. Biol. Chem. 2007)
    35. Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages. (PubMed id 16210695)1, 9 Armstrong L....Millar A.B. (Am. J. Respir. Cell Mol. Biol. 2006)
    36. The shedding activity of ADAM17 is sequestered in lipid rafts. (PubMed id 17010968)1, 9 Tellier E....Peiretti F. (Exp. Cell Res. 2006)
    37. Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. (PubMed id 12755693)1, 9 Endres K....Postina R. (Eur. J. Biochem. 2003)
    38. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex. (PubMed id 18638486)1, 9 Wisniewska M.... Bode W. (J. Mol. Biol. 2008)
    39. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. (PubMed id 16148149)1, 9 Shao M.X. and Nadel J.A. (J. Immunol. 2005)
    40. Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells. (PubMed id 14625290)1, 9 Cruz A.C....Fang K.C. (J. Biol. Chem. 2004)
    41. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. (PubMed id 14970227)1, 9 Bax D.V....Humphries M.J. (J. Biol. Chem. 2004)
    42. ADAM-10 and ADAM-17 in the inflamed human CNS. (PubMed id 12730960)1, 9 Kieseier B.C....Hartung H.P. (Glia 2003)
    43. Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation. (PubMed id 19949420)1, 9 Lisi S. and Sisto M. (Immunol. Cell Biol. 2010)
    44. ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices. (PubMed id 19666115)1, 9 Kwak H.I....Bayless K.J. (Matrix Biol. 2009)
    45. HDLs activate ADAM17-dependent shedding. (PubMed id 17786981)1, 9 Tellier E....Peiretti F. (J. Cell. Physiol. 2008)
    46. Tumour necrosis factor-alpha converting enzyme in human gestational tissues from pregnancies complicated by chorioamnionitis. (PubMed id 16376986)1, 9 Hung T.H....Hsieh T.T. (Placenta 2006)
    47. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. (PubMed id 16641105)1, 9 Zhang Q....Grandis J.R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    48. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome- coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). (PubMed id 15983030)1, 9 Lambert D.W.... Turner A.J. (J. Biol. Chem. 2005)
    49. Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. (PubMed id 12714588)1, 9 Borroto A....Arribas J. (J. Biol. Chem. 2003)
    50. ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. (PubMed id 19253070)1, 9 Oksala N....LehtimAoki T. (Ann. Med. 2009)
    51. Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme. (PubMed id 15308656)1, 9 Lee M.H....Murphy G. (J. Biol. Chem. 2004)
    52. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. (PubMed id 12972643)1, 9 Shao M.X....Nadel J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    53. Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme. (PubMed id 12706122)1, 9 Peiretti F....Nalbone G. (Exp. Cell Res. 2003)
    54. TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis. (PubMed id 12474981)1, 9 Seifert T....Hartung H.P. (Mult. Scler. 2002)
    55. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta. (PubMed id 10527948)1, 9 Nelson K.K.... Blobel C.P. (Biochem. J. 1999)
    56. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. (PubMed id 19324423)1, 9 Hurst L.A....Woodroofe M.N. (J. Neuroimmunol. 2009)
    57. Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor. (PubMed id 19171023)1, 9 MAoAottAo J.A....Salmivirta M. (BMC Cell Biol. 2009)
    58. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. (PubMed id 19296470)1, 9 Tsai W.C....Tsou A.P. (Hepatology 2009)
    59. Expression of tumor necrosis factor alpha converting enzyme in endocrine cancers. (PubMed id 18426733)1, 9 Kirkegaard T....Bartlett J.M. (Am. J. Clin. Pathol. 2008)
    60. Furin is an endogenous regulator of alpha-secretase associated APP processing. (PubMed id 16942750)1, 9 Hwang E.M....Mook-Jung I. (Biochem. Biophys. Res. Commun. 2006)
    61. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. (PubMed id 16336275)1, 9 Chokki M....Kamimura T. (FEBS J. 2005)
    62. Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme. (PubMed id 16079149)1, 9 Wei S....Brew K. (J. Biol. Chem. 2005)
    63. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme. (PubMed id 11988096)1, 9 Lee M.H....Murphy G. (Biochem. J. 2002)
    64. ADAM-17: the enzyme that does it all. (PubMed id 20184396)1, 9 Gooz M. (Crit. Rev. Biochem. Mol. Biol. 2010)
    65. GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE). (PubMed id 19762488)1, 9 Hiasa M....Matsumoto T. (Blood 2009)
    66. Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion. (PubMed id 19482949)1, 9 Brill A....Wagner D.D. (Cardiovasc. Res. 2009)
    67. CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. (PubMed id 19435795)1, 9 Gutwein P....Pfeilschifter J. (Am. J. Pathol. 2009)
    68. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. (PubMed id 18490652)1, 9 Haga S....Ishizaka Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    69. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. (PubMed id 18355445)1, 9 Hiraoka Y....Nishi E. (Biochem. Biophys. Res. Commun. 2008)
    70. Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. (PubMed id 18625725)1, 9 Wang S.E....Arteaga C.L. (Mol. Cell. Biol. 2008)
    71. Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. (PubMed id 17942404)1, 9 Ali N. and Knaeuper V. (J. Biol. Chem. 2007)
    72. Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. (PubMed id 17155946)1, 9 Qu D....Esmon C.T. (J. Thromb. Haemost. 2007)
    73. Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. (PubMed id 16982746)1, 9 Ringel J....LAPhr M. (Cancer Res. 2006)
    74. Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase. (PubMed id 16806063)1, 9 CissAc M.A....Vincent B. (Biochem. Biophys. Res. Commun. 2006)
    75. Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). (PubMed id 16332693)1, 9 Tsakadze N.L....D'Souza S.E. (J. Biol. Chem. 2006)
    76. The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. (PubMed id 15182369)1, 9 Allinson T.M....Hooper N.M. (Eur. J. Biochem. 2004)
    77. Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. (PubMed id 14532978)1, 9 Karan D....Batra S.K. (Int. J. Oncol. 2003)
    78. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. (PubMed id 12743035)1, 9 Gschwind A....Ullrich A. (EMBO J. 2003)
    79. Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. (PubMed id 9920899)1, 9 Roghani M....Blobel C.P. (J. Biol. Chem. 1999)
    80. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PubMed id 9806848)1, 9 Hirohata S....Apte S.S. (Genomics 1998)
    81. Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine. (PubMed id 24286866)1 Schweigert O....Scheller J. (Biochim. Biophys. Acta 2014)
    82. TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein. (PubMed id 24227843)1 Heurich A....PAPhlmann S. (J. Virol. 2014)
    83. GRO-I+/CXCR2 system and ADAM17 correlated expression in SjAPgren's syndrome. (PubMed id 23389772)1 Lisi S....Ribatti D. (Inflammation 2013)
    84. ADAM17 mediates MMP9 expression in lung epithelial cells. (PubMed id 23341882)1 Li Y.Q....Huang X.J. (PLoS ONE 2013)
    85. Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease. (PubMed id 23500026)1 Zhang J....Wang S. (Neurosci. Lett. 2013)
    86. A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3). (PubMed id 24121505)1 MAPller-Hackbarth K....Scheller J. (J. Biol. Chem. 2013)
    87. ADAM-17: a novel therapeutic target for triple negative breast cancer. (PubMed id 22967992)1 McGowan P.M....Duffy M.J. (Ann. Oncol. 2013)
    88. Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase. (PubMed id 23521534)1 DA1sterhAPft S....Lorenzen I. (J. Am. Chem. Soc. 2013)
    89. The disintegrin domain of ADAM17 antagonises fibroblasta89carcinoma cell interactions. (PubMed id 23545805)1 Trad A....Lorenzen I. (Int. J. Oncol. 2013)
    90. Jagged-1 juxtamembrane region: biochemical characterization and cleavage by ADAM17 (TACE) catalytic domain. (PubMed id 23416080)1 Coglievina M....Pintar A. (Biochem. Biophys. Res. Commun. 2013)
    91. ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway. (PubMed id 23625205)1 Wang X.J....Li M. (Mol. Cell. Biochem. 2013)
    92. MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. (PubMed id 23441135)1 Doberstein K....Gutwein P. (Neoplasia 2013)
    93. ADAM17 is overexpressed in non-small cell lung cancer and its expression correlates with poor patient survival. (PubMed id 23475633)1 Ni S.S....Wang J.L. (Tumour Biol. 2013)
    94. Characterization of the temporal and spatial expression of a disintegrin and metalloprotease 17 in the human endometrium and fallopian tube. (PubMed id 23585341)1 Jowicz A.P....Horne A.W. (Reprod Sci 2013)
    95. MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells. (PubMed id 23076445)1 Lu Y....Jiang F. (Oncol. Rep. 2013)
    96. Human breast cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-I+ cleavage by ADAM17. (PubMed id 23684931)1 Gao M.Q....Cho N.H. (Cancer Lett. 2013)
    97. ADAM17, shedding, TACE as therapeutic targets. (PubMed id 23415892)1 Rose-John S. (Pharmacol. Res. 2013)
    98. ADAM10/17-dependent release of soluble c-Met correlates with hepatocellular damage. (PubMed id 23746173)1 ChalupskA1 K....SedlA!A8ek R. (Folia Biol. (Praha) 2013)
    99. A brief history of tumor necrosis factor I+--converting enzyme: an overview of ectodomain shedding. (PubMed id 23563789)1 Horiuchi K. (Keio J Med 2013)
    100. Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CXa88 CL1 in rheumatoid arthritis. (PubMed id 23897050)1 Jones B.A....Ahmed S. (Arthritis Rheum. 2013)
    101. CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ADAM17 in a CD40 protein-dependent manner. (PubMed id 24189063)1 Yacoub D....Mourad W. (J. Biol. Chem. 2013)
    102. ADAM17 regulates self-renewal and differentiation of U87 glioblastoma stem cells. (PubMed id 23356982)1 Chen X....Wang X. (Neurosci. Lett. 2013)
    103. Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the &quot;a disintegrin and metalloproteases&quot; 10 and 17. (PubMed id 23526433)1 Chitadze G....Kabelitz D. (Int. J. Cancer 2013)
    104. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). (PubMed id 23487023)1 Romee R....Miller J. (Blood 2013)
    105. ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. (PubMed id 23349873)1 Sham D....van der Vliet A. (PLoS ONE 2013)
    106. The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. (PubMed id 24226769)2 Boskovski M.T....Khokha M.K. (Nature 2013)
    107. Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-I+ secretion and apoptosis. (PubMed id 23557259)1 Nagila A....Limjindaporn T. (Virol. J. 2013)
    108. Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases. (PubMed id 23479224)1 Tsubota Y....Raines E.W. (J. Immunol. 2013)
    109. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. (PubMed id 23674691)1 Miller M.A....Lauffenburger D.A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    110. Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. (PubMed id 24044434)1 Nuti E....Rossello A. (J. Med. Chem. 2013)
    111. The role of ADAM17 in metabolic inflammation. (PubMed id 23384719)1 Menghini R....Federici M. (Atherosclerosis 2013)
    112. TACE-dependent TGFI+ shedding drives triple-negative breast cancer cell invasion. (PubMed id 23729230)1 Giricz O....Kenny P.A. (Int. J. Cancer 2013)
    113. FcI^RIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens. (PubMed id 23460612)1 DAPbel T....SchAokel K. (Blood 2013)
    114. Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells. (PubMed id 21932060)1 Li Y....Xia Y. (Inflammation 2012)
    115. Prognostic value of ADAM17 in human gastric cancer. (PubMed id 22139867)1 Zhang T.C....Chen X.F. (Med. Oncol. 2012)
    116. Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide. (PubMed id 22367719)1 Dreymueller D....Ludwig A. (EMBO Mol Med 2012)
    117. Homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of MCP1, Hsp60 and ADAM17. (PubMed id 22319627)1 Capasso R....Ingrosso D. (PLoS ONE 2012)
    118. Upregulated expression of ADAM17 is a prognostic marker for patients with gastric cancer. (PubMed id 22668812)1 Shou Z.X....Zhao Z.S. (Ann. Surg. 2012)
    119. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    120. MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. (PubMed id 22677042)1 Xu K....Liu J. (Exp. Cell Res. 2012)
    121. Identification of novel interaction between ADAM17 (a disintegrin and metalloprotease 17) and thioredoxin-1. (PubMed id 23105116)1 AragALo A.Z....Paes Leme A.F. (J. Biol. Chem. 2012)
    122. The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and I^-secretase, enhances cell proliferation and migration in colon cancer cells. (PubMed id 22665490)1 Na H.W....Lee S.T. (J. Biol. Chem. 2012)
    123. Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region. (PubMed id 23011796)1 Stephenson N.L. and Avis J.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    124. ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion. (PubMed id 22200661)1 Xiao L.J....Yu X.G. (Int. J. Oncol. 2012)
    125. Unlike for human monocytes after LPS activation, release of TNF-I+ by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. (PubMed id 22479555)1 Moreira-Tabaka H....Muller C.D. (PLoS ONE 2012)
    126. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. (PubMed id 22105359)1 Rzymski T....GAPrlach A. (Oncogene 2012)
    127. Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation. (PubMed id 22613720)1 Sommer A....Reiss K. (J. Biol. Chem. 2012)
    128. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). (PubMed id 22833676)1 Breshears L.M....Peterson M.L. (J. Biol. Chem. 2012)
    129. Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics. (PubMed id 21501859)1 Narita D....Anghel A. (Acta Histochem. 2012)
    130. Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17. (PubMed id 22965144)1 Lucitti J.L....Faber J.E. (Circ. Res. 2012)
    131. Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735. (PubMed id 22384041)1 Hall K.C. and Blobel C.P. (PLoS ONE 2012)
    132. Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators. (PubMed id 22770404)1 Guo S....Zhang W. (Chin. Med. Sci. J. 2012)
    133. Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. (PubMed id 22927435)1 Minond D....Fields G.B. (J. Biol. Chem. 2012)
    134. Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. (PubMed id 22174390)4 Rankinen T....Bouchard C. (J. Appl. Physiol. 2012)
    135. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. (PubMed id 22550340)1 Xu P....Derynck R. (Sci Signal 2012)
    136. ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway. (PubMed id 21837402)1 Lin P....Yu X. (Mol. Cell. Biochem. 2012)
    137. Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain. (PubMed id 22933306)1 Gil-Bea F....Cedazo-Minguez A. (EMBO Mol Med 2012)
    138. ADAM17 promotes glioma cell malignant phenotype. (PubMed id 21480393)1 Zheng X....Chopp M. (Mol. Carcinog. 2012)
    139. SjAPgren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-I_B. (PubMed id 22157716)1 Lisi S....D'Amore M. ( a journal of technical methods and pathology 2012)
    140. The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II. (PubMed id 22575642)1 Lorenzen I....GrAPtzinger J. (FEBS Lett. 2012)
    141. [Inhibitory effect of siRNA targeting ADAM17 on the proliferation of prostate cancer PC-3 cells]. (PubMed id 22934512)1 Lin F....Yu X.G. (Zhonghua Nan Ke Xue 2012)
    142. Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. (PubMed id 22772468)1 Guinea-Viniegra J....Wagner E.F. (J. Clin. Invest. 2012)
    143. Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. (PubMed id 22506015)1 Hoa N....Smith T.J. (PLoS ONE 2012)
    144. Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin. (PubMed id 22438584)1 Nakayama H....Higashiyama S. (Mol. Biol. Cell 2012)
    145. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    146. Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. (PubMed id 22689693)1 Yang Y....Wang Y.L. (J. Clin. Endocrinol. Metab. 2012)
    147. ADAM17 regulates TNFI+ production by placental trophoblasts. (PubMed id 22018416)1 Ma R....Wang Y. (Placenta 2011)
    148. Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression. (PubMed id 21102583)1 Kornfeld J.W....Riethdorf S. (Br. J. Cancer 2011)
    149. Tumor necrosis factor-I+: investigation of gene polymorphism and regulation of TACE-TNF-I+ system in patients with acute myocardial infarction. (PubMed id 21153921)1 Ghaderian S.M....Tabatabaei Panah A.S. (Mol. Biol. Rep. 2011)
    150. ADAM-17 over-expression in gallbladder carcinoma correlates with poor prognosis of patients. (PubMed id 20300969)1 Wu K....Deng Z. (Med. Oncol. 2011)
    151. A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17. (PubMed id 20871631)1 Maretzky T....Blobel C.P. (Oncogene 2011)
    152. ADAM12 and ADAM17 gene expression in laser-capture microdissected and non-microdissected breast tumors. (PubMed id 21240579)1 Narita D....Anghel A. (Pathol. Oncol. Res. 2011)
    153. P2Y6 receptors and ADAM17 mediate low-dose gamma-ray-induced focus formation (activation) of EGF receptor. (PubMed id 21268712)1 Tamaishi N....Kojima S. (Radiat. Res. 2011)
    154. Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation. (PubMed id 21949123)1 Wang Y....Walcheck B. (J. Biol. Chem. 2011)
    155. Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. (PubMed id 21407195)1 Maretzky T....Blobel C.P. (Nat Commun 2011)
    156. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    157. TGF-I^1 promotes motility and invasiveness of glioma cells through activation of ADAM17. (PubMed id 21359495)1 Lu Y....Chopp M. (Oncol. Rep. 2011)
    158. ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers. (PubMed id 21175594)1 Sinnathamby G....Philip R. (Clin. Exp. Immunol. 2011)
    159. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. (PubMed id 21300824)1 Kim S....Nadel J.A. (J. Immunol. 2011)
    160. ADAM17 (TACE) regulates TGFI^ signaling through the cleavage of vasorin. (PubMed id 21170088)1 Malapeira J....Arribas J. (Oncogene 2011)
    161. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. (PubMed id 21423656)1 Lemjabbar-Alaoui H....Basbaum C. (PLoS ONE 2011)
    162. Tumor necrosis factor-I+ converting enzyme (TACE) increases RANKL expression in osteoblasts and serves as a potential biomarker of periodontitis. (PubMed id 21777519)1 Lee J.H....Cho J.Y. (BMB Rep 2011)
    163. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor I+-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. (PubMed id 21865167)1 Scott A.J....Takata M. (J. Biol. Chem. 2011)
    164. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    165. The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9. (PubMed id 21365281)1 GutiAcrrez-LA^pez M.D....CabaA+as C. (Cell. Mol. Life Sci. 2011)
    166. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    167. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. (PubMed id 21925169)1 Kim S....Nadel J.A. (Exp. Cell Res. 2011)
    168. PKCI+ and PKCI' regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. (PubMed id 21386996)1 Kveiborg M....Parker P.J. (PLoS ONE 2011)
    169. Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells. (PubMed id 20506406)1 Liu W.H....Chang L.S. (J. Cell. Biochem. 2010)
    170. Tumor necrosis factor I+-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. (PubMed id 20807704)1 Etzerodt A....Moestrup S.K. (J. Leukoc. Biol. 2010)
    171. Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality. (PubMed id 20359533)1 Dusso A....Tokumoto M. (J. Steroid Biochem. Mol. Biol. 2010)
    172. Junctional adhesion molecule-C is a soluble mediator of angiogenesis. (PubMed id 20592283)2 Rabquer B.J.... Koch A.E. (J. Immunol. 2010)
    173. ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. (PubMed id 20551051)1 Baumgart A....Dechow T. (Cancer Res. 2010)
    174. Effects of pro-inflammatory cytokines on the production of soluble fractalkine and ADAM17 by HepG2 cells. (PubMed id 20922190)1 Turner S.L....Bunning R.A. (J Gastrointestin Liver Dis 2010)
    175. Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages. (PubMed id 20118276)1 Hakozaki A....Toyama Y. (J. Immunol. 2010)
    176. Suppression of ADAM17-mediated Lyn/Akt pathways induces apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhibitor-like protein-1 uncovers the cytotoxic mechanism. (PubMed id 20679348)1 Liu W.H. and Chang L.S. (J. Biol. Chem. 2010)
    177. Acetylenic inhibitors of ADAM10 and ADAM17: in silico analysis of potency and selectivity. (PubMed id 20863729)1 Healy E.F....Lindfors G. (amp 2010)
    178. Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event. (PubMed id 20819075)1 Parr-Sturgess C.A....Parkin E.T. (Biochem. J. 2010)
    179. Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. (PubMed id 20059578)1 Peng M....Zhang W. (Immunology 2010)
    180. Expression of pro-inflammatory TACE-TNF-I+-amphiregulin axis in SjAPgren's syndrome salivary glands. (PubMed id 20811902)1 Sisto M....D'Amore M. (Histochem. Cell Biol. 2010)
    181. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    182. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. (PubMed id 20026129)1 Chalaris A....Scheller J. (Biochim. Biophys. Acta 2010)
    183. A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells. (PubMed id 19875451)1 Pruessmeyer J....Ludwig A. (J. Biol. Chem. 2010)
    184. Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation. (PubMed id 20221248)1 Edwards M....Parra E.J. (PLoS Genet. 2010)
    185. Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models. (PubMed id 20180536)1 Nuti E....Rossello A. (J. Med. Chem. 2010)
    186. The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. (PubMed id 19278423)1 Oh S.T....Reichrath J. (J. Cutan. Pathol. 2009)
    187. Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. (PubMed id 19515085)1 Katakowski M....Chopp M. (Cancer Sci. 2009)
    188. In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production. (PubMed id 19376560)1 Mosnier J.F....Laboisse C.L. (Hum. Pathol. 2009)
    189. Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. (PubMed id 19564338)1 Taylor D.R....Hooper N.M. (J. Biol. Chem. 2009)
    190. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis. (PubMed id 19150341)1 GAPoz P....Hoffman S. (Biochem. Biophys. Res. Commun. 2009)
    191. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    192. [The two sides of ADAM17 in inflammation: implications in atherosclerosis and obesity]. (PubMed id 19154693)1 Peiretti F....Nalbone G. (Med Sci (Paris) 2009)
    193. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. (PubMed id 19704010)1 Bozkulak E.C. and Weinmaster G. (Mol. Cell. Biol. 2009)
    194. Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. (PubMed id 19091752)1 Liu Y....Fassbender K. (J. Biol. Chem. 2009)
    195. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. (PubMed id 19541935)1 Weinger J.G....Shafit-Zagardo B. (Am. J. Pathol. 2009)
    196. Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia. (PubMed id 19772640)1 Szalad A....Chopp M. (amp 2009)
    197. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. (PubMed id 19003995)1 Singh B....Ullrich A. (Int. J. Cancer 2009)
    198. Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE. (PubMed id 19959661)1 Battaglia-Hsu S.F....GuAcant J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    199. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. (PubMed id 19595713)1 Liu C....Derynck R. (Mol. Cell 2009)
    200. Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands. (PubMed id 19298600)1 Nakagawa M....Iwasaki H. (Cancer Sci. 2009)
    201. UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes. (PubMed id 18483258)1 He Y.Y....Chignell C.F. (Cancer Res. 2008)
    202. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    203. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. (PubMed id 18818406)1 Swendeman S....Blobel C.P. (Circ. Res. 2008)
    204. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    205. Reduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis. (PubMed id 18167350)1 Paland N....Rudel T. (J. Biol. Chem. 2008)
    206. Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease. (PubMed id 18396294)1 Wang B....Ma X. (J. Neurol. Sci. 2008)
    207. Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. (PubMed id 17999917)1 Takamune Y....Shinohara M. (Biochem. Biophys. Res. Commun. 2008)
    208. Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17. (PubMed id 18979631)1 Esselens C.W....Arribas J. (Biol. Chem. 2008)
    209. Tumor-associated MICA is shed by ADAM proteases. (PubMed id 18676862)1 Waldhauer I....Steinle A. (Cancer Res. 2008)
    210. The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. (PubMed id 18373975)1 Schramme A....Gutwein P. (Biochem. Biophys. Res. Commun. 2008)
    211. Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL. (PubMed id 18922903)1 Van Schaeybroeck S....Longley D.B. (Cancer Res. 2008)
    212. Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z. (PubMed id 18713734)1 Chow J.P....Noda M. (J. Biol. Chem. 2008)
    213. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. (PubMed id 18824549)1 Hartl D....Elias J.A. (J. Biol. Chem. 2008)
    214. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. (PubMed id 18281553)1 Merchant N.B....Coffey R.J. (Clin. Cancer Res. 2008)
    215. ADAM-17 predicts adverse outcome in patients with breast cancer. (PubMed id 18238782)1 McGowan P.M....Duffy M.J. (Ann. Oncol. 2008)
    216. Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes. (PubMed id 17714581)1 Worley J.R....Sampson M.J. (Cardiovasc Diabetol 2007)
    217. Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. (PubMed id 17360351)1 Solomon A....Sagi I. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    218. TACE: a new target in epidermal growth factor receptor dependent tumors. (PubMed id 17608729)1 Kenny P.A. ( research in biological diversity 2007)
    219. EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing. (PubMed id 17655843)1 Buffin-Meyer B....Paris H. (Eur. J. Pharmacol. 2007)
    220. ERp57 is essential for efficient folding of glycoproteins sharing common structural domains. (PubMed id 17170699)1 Jessop C.E....Bulleid N.J. (EMBO J. 2007)
    221. Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? (PubMed id 17986144)1 Bronfman F.C. (J. Neurochem. 2007)
    222. The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells. (PubMed id 18171982)1 Rosso O....Fabbi M. (Mol. Cancer Res. 2007)
    223. Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. (PubMed id 17405915)1 Bachmeier B.E....Boos N. (Ann. N. Y. Acad. Sci. 2007)
    224. EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing. (PubMed id 16478662)1 Ruhe J.E....Ullrich A. (Cell. Signal. 2006)
    225. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. (PubMed id 16912185)1 Franovic A....Lee S. (Cancer Res. 2006)
    226. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. (PubMed id 16619241)1 Canault M....Peiretti F. (J. Cell. Physiol. 2006)
    227. Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. (PubMed id 16900751)1 Plumb J....Woodroofe M.N. (Mult. Scler. 2006)
    228. Alcohol reversibly disrupts TNF-alpha/TACE interactions in the cell membrane. (PubMed id 16246259)1 Song K....Kolls J.K. (Respir. Res. 2005)
    229. Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. (PubMed id 15691827)1 Rabie T....Nieswandt B. (J. Biol. Chem. 2005)
    230. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. (PubMed id 15784625)1 Fabre-Lafay S.... Lopez M. (J. Biol. Chem. 2005)
    231. Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases. (PubMed id 16279945)1 Endres K....Fahrenholz F. (FEBS J. 2005)
    232. Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling. (PubMed id 16034137)1 GA^mez M.I....Prince A.S. (J. Immunol. 2005)
    233. Aspirin induces platelet receptor shedding via ADAM17 (TACE). (PubMed id 16179345)1 Aktas B....Nieswandt B. (J. Biol. Chem. 2005)
    234. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. (PubMed id 15534001)1 Williams C.C.... Jones F.E. (J. Cell Biol. 2004)
    235. A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin. (PubMed id 15066987)1 Valeva A....Zitzer A. (J. Biol. Chem. 2004)
    236. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (PubMed id 15280379)1 Tanaka M.... Higashiyama S. (J. Biol. Chem. 2004)
    237. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    238. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. (PubMed id 15337756)1 SchAofer B....Ullrich A. (J. Biol. Chem. 2004)
    239. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. (PubMed id 12711607)1 Lemjabbar H....Basbaum C. (J. Biol. Chem. 2003)
    240. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). (PubMed id 12832423)1 Matthews V....Rose-John S. (J. Biol. Chem. 2003)
    241. Identification of SAP97 as an intracellular binding partner of TACE. (PubMed id 12668732)1 Peiretti F....Nalbone G. (J. Cell. Sci. 2003)
    242. Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. (PubMed id 12810728)1 Contin C....DAcchanet-Merville J. (J. Biol. Chem. 2003)
    243. Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. (PubMed id 12947092)1 Le Gall S.M....Mauduit P. (J. Biol. Chem. 2003)
    244. TACE is required for the activation of the EGFR by TGF-alpha in tumors. (PubMed id 12606576)1 Borrell-PagA"s M....Arribas J. (EMBO J. 2003)
    245. Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. (PubMed id 12777399)1 Fourie A.M....Karlsson L. (J. Biol. Chem. 2003)
    246. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. (PubMed id 12535668)1 Asai M....Ishiura S. (Biochem. Biophys. Res. Commun. 2003)
    247. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). (PubMed id 12568494)1 Basbaum C....Lemjabbar H. (Novartis Found. Symp. 2002)
    248. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. (PubMed id 12135369)1 Mohan M.J....Milla M.E. (Biochemistry 2002)
    249. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3. (PubMed id 12044879)1 Lee M.H....Murphy G. (FEBS Lett. 2002)
    250. Tumor necrosis factor-alpha converting enzyme. (PubMed id 11733179)1 Black R.A. (amp 2002)
    251. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PubMed id 11741929)1 Poghosyan Z....Edwards D.R. (J. Biol. Chem. 2002)
    252. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. (PubMed id 12207026)1 Zheng Y....Blobel C.P. (J. Biol. Chem. 2002)
    253. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. (PubMed id 11823465)1 Sunnarborg S.W....Lee D.C. (J. Biol. Chem. 2002)
    254. Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. (PubMed id 12147693)1 GA^mez-Gaviro M.V....DA-az-GonzA!lez F. (J. Biol. Chem. 2002)
    255. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    256. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. (PubMed id 10799478)1 English W.R....Murphy G. (J. Biol. Chem. 2000)
    257. Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS. (PubMed id 10860581)1 KAorkkAoinen I....Huovila A.P. (Mol. Cell. Neurosci. 2000)
    258. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. (PubMed id 10882063)1 Brou C....IsraAl A. (Mol. Cell 2000)
    259. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    260. Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25. (PubMed id 10433800)1 Cerretti D.P....Nelson N. (Cytokine 1999)
    261. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. (PubMed id 10224132)1 Lum L....Blobel C.P. (J. Biol. Chem. 1999)
    262. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. (PubMed id 9774383)1 Buxbaum J.D....Black R.A. (J. Biol. Chem. 1998)
    263. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. (PubMed id 9620803)1 Schroeter E.H....Kopan R. (Nature 1998)
    264. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    265. ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. (PubMed id 19395875)9 Zheng X....Chopp M. (amp 2009)
    266. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. (PubMed id 15100227)9 Gonzales P.E....Milla M.E. (J. Biol. Chem. 2004)
    267. Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodies. (PubMed id 19854762)9 Sisto M....D'Amore M. (Int. Immunol. 2009)
    268. Identification of key sequence determinants for the inhibitory function of the prodomain of TACE. (PubMed id 18707126)9 Gonzales P.E....Milla M.E. (Biochemistry 2008)
    269. Tumour necrosis factor-alpha converting enzyme (TACE) activity in human colonic epithelial cells. (PubMed id 14678276)9 Kirkegaard T....Brynskov J. (Clin. Exp. Immunol. 2004)
    270. Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch. (PubMed id 15749738)9 Buckley C.A....Levine S.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2005)
    271. Tumor necrosis factor-alpha-converting enzyme and tumor necrosis factor-alpha in human dilated cardiomyopathy. (PubMed id 10385500)9 Satoh M....Hiramori K. (Circulation 1999)
    272. Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure. (PubMed id 15556048)9 Satoh M....Hiramori K. (Eur. J. Heart Fail. 2004)
    273. Porphyromonas gingivalis stimulates TACE production by T cells. (PubMed id 19239642)9 Bostanci N....Belibasakis G.N. (Oral Microbiol. Immunol. 2009)
    274. Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. (PubMed id 16041691)9 Blanchot-Jossic F....Mosnier J.F. (J. Pathol. 2005)
    275. Overexpression of tumour necrosis factor-alpha-converting enzyme in psoriasis. (PubMed id 15888146)9 Kawaguchi M....Kondo S. (Br. J. Dermatol. 2005)
    276. ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. (PubMed id 15923650)9 Soond S.M....Murphy G. (J. Cell. Sci. 2005)
    277. Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells. (PubMed id 15206946)9 Bzowska M....Bereta J. (Eur. J. Biochem. 2004)
    278. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). (PubMed id 15075334)9 Li X. and Fan H. (J. Biol. Chem. 2004)
    279. Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis. (PubMed id 11028485)9 Satoh M....Hiramori K. (J. Am. Coll. Cardiol. 2000)
    280. Regulation of mature ADAM17 by redox agents for L-selectin shedding. (PubMed id 19201900)9 Wang Y....Walcheck B. (J. Immunol. 2009)
    281. ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma. (PubMed id 17180679)9 Takamune Y....Shinohara M. (Virchows Arch. 2007)
    282. The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors. (PubMed id 16214147)9 Canault M....Nalbone G. (Atherosclerosis 2006)
    283. Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis. (PubMed id 11508576)9 Ohta S....Kamatani N. (J. Rheumatol. 2001)
    284. cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. (PubMed id 10375622)9 Mizui Y....Tanaka I. (Gene 1999)
    285. Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha. (PubMed id 19767822)9 Hikita A....Fukui N. (Biochem. Cell Biol. 2009)
    286. ADAM17 as a therapeutic target in multiple diseases. (PubMed id 19601834)9 Arribas J. and Esselens C. (Curr. Pharm. Des. 2009)
    287. The expression of TNF-alpha converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction. (PubMed id 18226043)9 Satoh M....Nakamura M. (Eur. J. Clin. Invest. 2008)
    288. The transmembrane domain of TACE regulates protein ectodomain shedding. (PubMed id 18040288)9 Li X....Fan H. (Cell Res. 2007)
    289. TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis. (PubMed id 16511637)9 Comabella M....Montalban X. (J. Neurol. 2006)
    290. Activated tumour necrosis factor-alpha shedding process is associated with in-hospital complication in patients with acute myocardial infarction. (PubMed id 15603556)9 Shimoda Y....Hiramori K. (Clin. Sci. 2005)
    291. Release of tumour necrosis factor alpha (TNFalpha) by TNFalpha cleaving enzyme (TACE) in response to septic stimuli in vitro. (PubMed id 15556967)9 Robertshaw H.J. and Brennan F.M. (Br J Anaesth 2005)
    292. Expression and localization of tumour necrosis factor-alpha and its converting enzyme in human abdominal aortic aneurysm. (PubMed id 14580234)9 Satoh H....Hiramori K. (Clin. Sci. 2004)
    293. Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway. (PubMed id 14751236)9 Villanueva de la Torre T....Arribas J. (Biochem. Biophys. Res. Commun. 2004)
    294. Application of peptides containing the cleavage sequence of pro-TNFalpha in assessing TACE activity of whole cells. (PubMed id 12530549)9 Becker B.F....Zahler S. (Biol. Chem. 2002)
    295. Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. (PubMed id 11156944)9 Zhang Z....Kolls J.K. (FASEB J. 2001)
    296. ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney fibrosis. (PubMed id 20087163)9 Bell H.L. and GAPAPz M. (Am. J. Med. Sci. 2010)
    297. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. (PubMed id 19371428)9 Liu Q....Bu G. (Mol Neurodegener 2009)
    298. Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains. (PubMed id 19234765)9 Bernstein H.G....Reiser G. (Age (Dordr) 2009)
    299. Multiple shRNA-mediated knockdown of TACE reduces the malignancy of HeLa cells. (PubMed id 18996214)9 Yan Y....Yang Y.Z. (Cell Biol. Int. 2009)
    300. Neutrophil adhesion to E-selectin under shear promotes the redistribution and co-clustering of ADAM17 and its proteolytic substrate L-selectin. (PubMed id 17928459)9 Schaff U....Walcheck B. (J. Leukoc. Biol. 2008)
    301. Upregulation of tumor necrosis factor receptor 1 and TNF-alpha converting enzyme during corneal wound healing. (PubMed id 18991041)9 Sakimoto T....Sawa M. (Jpn. J. Ophthalmol. 2008)
    302. Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases. (PubMed id 18296613)9 Bostanci N....Belibasakis G.N. (J. Dent. Res. 2008)
    303. Differential regulation of tumor necrosis factor-alpha-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells. (PubMed id 16799629)9 Obeid D....Bauvois B. (Oncogene 2007)
    304. Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. (PubMed id 16762326)9 Marshall A.J....Vaughan P.F. (Brain Res. 2006)
    305. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. (PubMed id 16737974)9 GAPoz M....Raymond J.R. (J. Biol. Chem. 2006)
    306. IK682, a tight binding inhibitor of TACE. (PubMed id 16762314)9 Niu X....Orth P. (Arch. Biochem. Biophys. 2006)
    307. Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. (PubMed id 15641051)9 Franchimont N....Malaise M. (Arthritis Rheum. 2005)
    308. [Screening of TACE peptide inhibitors from a phage display random 15-peptide library by recombinant TACE ecotodomain]. (PubMed id 15859325)9 Huang W....Yang Y.Z. (Sheng Wu Gong Cheng Xue Bao 2005)
    309. Gene expression profiles of TNF-alpha, TACE, furin, IL-1beta and matrilysin in UVA- and UVB-irradiated HaCat cells. (PubMed id 15998365)9 Skiba B....Piva T.J. (amp 2005)
    310. Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme. (PubMed id 15531300)9 Zhang Y....Levin J. (Int. Immunopharmacol. 2004)
    311. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. (PubMed id 12849708)9 Ermert M....Ermert L. (Cytokine 2003)
    312. Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form. (PubMed id 11277930)9 Itai T....Nagata S. (Eur. J. Biochem. 2001)
    313. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase. (PubMed id 11162616)9 Lee M.H....Murphy G. (Biochem. Biophys. Res. Commun. 2001)
    314. ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes. (PubMed id 11334139)9 Condon T.P....Bennett C.F. (amp 2001)
    315. Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. (PubMed id 10799547)9 Reddy P....Black R.A. (J. Biol. Chem. 2000)
    316. Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion. (PubMed id 10510344)9 Solomon K.A....Newton R.C. (J. Immunol. 1999)
    317. Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). (PubMed id 10521439)9 Milla M.E....Becherer J.D. (J. Biol. Chem. 1999)
    318. Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. (PubMed id 9733803)9 Merlos-SuA!rez A....Arribas J. (J. Biol. Chem. 1998)
    319. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. (PubMed id 19995578)9 Haga S....Ishizaka Y. (Antiviral Res. 2010)
    320. Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. (PubMed id 17464354)9 PAcrez L....Fan H. (Biochem. Cell Biol. 2007)
    321. [Inhibition of proliferation, adhesion and invasion ability of human lung carcinoma cell A549 by tumor necrosis factor-alpha converting enzyme (TACE)]. (PubMed id 17822026)9 Yan Y....Yang Y.Z. (Sheng Wu Gong Cheng Xue Bao 2007)
    322. Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. (PubMed id 17884817)9 Charbonneau M....Dubois C.M. (J. Biol. Chem. 2007)
    323. The TACE zymogen: re-examining the role of the cysteine switch. (PubMed id 16679521)9 Milla M.E....Leonard J.D. (Cell Biochem. Biophys. 2006)
    324. Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain. (PubMed id 16399672)9 Lomniczi A....Ojeda S.R. (J. Neurosci. 2006)
    325. Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase. (PubMed id 16724341)9 Bandyopadhyay S....Rogers J.T. (J. Neurosci. Res. 2006)
    326. Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. (PubMed id 15942356)9 Kermarrec N....Chollet-Martin S. (Crit. Care Med. 2005)
    327. Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers. (PubMed id 14659806)9 Gilles S....Becker B.F. (Cardiovasc. Res. 2003)
    328. Structural features and biochemical properties of TNF-alpha converting enzyme (TACE). (PubMed id 9042103)9 Moss M.L....Willard D. (J. Neuroimmunol. 1997)
    329. The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. (PubMed id 20022498)9 Rosner K.E....Strickland C.O. (amp 2010)
    330. Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3. (PubMed id 19292764)9 Armstrong L....Millar A.B. (Clin. Exp. Immunol. 2009)
    331. Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). (PubMed id 17368021)9 Sheppeck J.E....Duan J.J. (amp 2007)
    332. Comparison of properties of tumor necrosis factor-alpha converting enzyme (TACE) and some matrix metalloproteases (MMPs) in catalytic domains. (PubMed id 17357475)9 Zhao Y....Chen R. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2006)
    333. Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production. (PubMed id 16273118)9 Jarry A....Laboisse C.L. (Br. J. Pharmacol. 2006)
    334. Janus kinase 2 influences growth hormone receptor metalloproteolysis. (PubMed id 16497804)9 Loesch K....Frank S.J. (Endocrinology 2006)
    335. Localization of tumour necrosis factor-alpha converting enzyme in normal human skin. (PubMed id 14987279)9 Kawaguchi M....Kondo S. (Clin. Exp. Dermatol. 2004)
    336. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. (PubMed id 15121636)9 Shao M.X....Nadel J.A. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
    337. Acute alcohol inhibits TNF-alpha processing in human monocytes by inhibiting TNF/TNF-alpha-converting enzyme interactions in the cell membrane. (PubMed id 12626543)9 Zhao X.J....Kolls J.K. (J. Immunol. 2003)
    338. Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis. (PubMed id 10849774)9 Gottschalk C....Ansorge S. (Adv. Exp. Med. Biol. 2000)
    339. New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. (PubMed id 10579851)9 Barlaam B....Maciewicz R. (J. Med. Chem. 1999)
    340. [Screening of ADAMs that can mediate the generation of soluble MHC I]. (PubMed id 20306608)9 Zhao J.R. and Yan Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010)
    341. The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding. (PubMed id 20331435)9 Killock D.J. and IvetiA8 A. (Biochem. J. 2010)
    342. Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseases. (PubMed id 20303413)9 Ramana K.V. (amp 2010)
    343. Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (PubMed id 19131941)9 Hoareau L....Roche R. (Obesity (Silver Spring) 2009)
    344. ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli. (PubMed id 19386603)9 Boots A.W....van der Vliet A. (J. Biol. Chem. 2009)
    345. ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells. (PubMed id 18971959)9 Anderegg U....Simon J.C. (J. Invest. Dermatol. 2009)
    346. The role of ADAMs in disease pathophysiology. (PubMed id 19408347)9 Duffy M.J....McGowan P.M. ( international journal of clinical chemistry 2009)
    347. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. (PubMed id 18171996)9 Zhuang S....Schnellmann R.G. (Am. J. Physiol. Renal Physiol. 2008)
    348. Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. (PubMed id 18452483)9 Itabashi H....Masuda T. (Hepatol. Res. 2008)
    349. Expression of metalloproteinases (MMP-2, MMP-9, and TACE) and TNF-alpha in the nerves of leprosy patients. (PubMed id 17868246)9 Teles R.M....Sarno E.N. (J. Peripher. Nerv. Syst. 2007)
    350. The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies. (PubMed id 17207628)9 Dehmel T....Kieseier B.C. (Neurobiol. Dis. 2007)
    351. Metalloproteases regulate T-cell proliferation and effector function via LAG-3. (PubMed id 17245433)9 Li N....Vignali D.A. (EMBO J. 2007)
    352. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. (PubMed id 17895248)9 Moss M.L....Zhou P. (J. Biol. Chem. 2007)
    353. ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains. (PubMed id 17027649)9 Thiel K.W. and Carpenter G. (Biochem. Biophys. Res. Commun. 2006)
    354. Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292. (PubMed id 16427093)9 Chokki M....Kamimura T. (Life Sci. 2006)
    355. Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells. (PubMed id 16783171)9 Auerbach I.D. and Vinters H.V. (J. Neuropathol. Exp. Neurol. 2006)
    356. Therapeutic potential of TACE inhibitors in stroke. (PubMed id 15857301)9 Lovering F. and Zhang Y. (Curr Drug Targets CNS Neurol Disord 2005)
    357. Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition. (PubMed id 14734567)9 Lee M.H....Murphy G. (J. Biol. Chem. 2004)
    358. Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. (PubMed id 15034047)9 von Tresckow B....Hansen H.P. (J. Immunol. 2004)
    359. Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. (PubMed id 14718605)9 Zhang Y....Lin L.L. (J. Pharmacol. Exp. Ther. 2004)
    360. Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors. (PubMed id 12951101)9 Letavic M.A....Yu C.H. (amp 2003)
    361. Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity. (PubMed id 14587281)9 Black R.A....Paxton R. (Biochem. Soc. Symp. 2003)
    362. Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail. (PubMed id 14587283)9 Murphy G....Williamson R. (Biochem. Soc. Symp. 2003)
    363. Shedding of membrane proteins by ADAM family proteases. (PubMed id 12463167)9 Moss M.L. and Lambert M.H. (Essays Biochem. 2002)
    364. [Effect of reduqing on HL-60 cells in secreting tumor necrosis factor alpha production and on TNF alpha converting enzyme mRNA expression]. (PubMed id 12577359)9 Wang K.F....Yang Y.Z. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2001)
    365. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). (PubMed id 11495925)9 Garton K.J....Raines E.W. (J. Biol. Chem. 2001)
    366. Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages. (PubMed id 10818238)9 Wang K.Y....Sasaguri Y. (FEBS Lett. 2000)
    367. Expression of tumor necrosis factor-alpha in cultured human endothelial cells stimulated with lipopolysaccharide or interleukin-1alpha. (PubMed id 10669637)9 Imaizumi T....Satoh K. (Arterioscler. Thromb. Vasc. Biol. 2000)
    368. (PubMed id 18395853)9 
    369. ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding? (PubMed id 20504280)9 Bass R. and Edwards D.R. (Biochem. J. 2010)
    370. Novel TACE inhibitors in drug discovery: a review of patented compounds. (PubMed id 20021284)9 Murumkar P.R....Yadav M.R. (Expert Opin Ther Pat 2010)
    371. Cell-cell interaction promotes rat marrow stromal cell differentiation into endothelial cell via activation of TACE/TNF-alpha signaling. (PubMed id 19796498)9 Xu J....Liu Z. (Cell Transplant 2010)
    372. Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. (PubMed id 20305301)9 Stokes A....KAohAori V.M. (Clin. Cancer Res. 2010)
    373. TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. (PubMed id 19890373)9 Vahdat A.M....Hansen H.P. (Leukemia 2010)
    374. Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha-converting enzyme-dependent ectodomain shedding. (PubMed id 19407014)9 Sakimoto T....Sawa M. (amp 2009)
    375. The regulation of TACE catalytic function by its prodomain. (PubMed id 18386160)9 Li X....Chang L. (Mol. Biol. Rep. 2009)
    376. Chimeric form of tumor necrosis factor-alpha has enhanced surface expression and antitumor activity. (PubMed id 18654609)9 Rieger R....Kipps T.J. (Cancer Gene Ther. 2009)
    377. Current perspective of TACE inhibitors: a review. (PubMed id 19095454)9 DasGupta S....Yadav M.R. (amp 2009)
    378. Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. (PubMed id 19825997)9 Gilmore J.L....Foley J. (Mol. Cancer Res. 2009)
    379. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. (PubMed id 19250983)9 Yan F....Polk D.B. (Gastroenterology 2009)
    380. ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. (PubMed id 18658095)9 Yin J. and Yu F.S. (amp 2009)
    381. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. (PubMed id 19411314)9 Jia H.P....McCray P.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    382. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. (PubMed id 19581416)9 Cardellini M....Federici M. (Diabetes 2009)
    383. Role of ADAMs in cancer formation and progression. (PubMed id 19228719)9 Duffy M.J....McGowan P.M. (Clin. Cancer Res. 2009)
    384. CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo. (PubMed id 19534723)9 Chikaraishi Y....Hara H. (Curr Neurovasc Res 2009)
    385. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. (PubMed id 19147560)9 Wang S.E....Arteaga C.L. (Cancer Res. 2009)
    386. Identification of five candidate lung cancer biomarkers by proteomics analysis of conditioned media of four lung cancer cell lines. (PubMed id 19776420)9 Planque C....Diamandis E.P. (amp 2009)
    387. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. (PubMed id 18621108)9 Candelario-Jalil E....Rosenberg G.A. (Neuroscience 2009)
    388. Prediction of novel and selective TNF-alpha converting enzyme (TACE) inhibitors and characterization of correlative molecular descriptors by machine learning approaches. (PubMed id 19729328)9 Cong Y....Xue Y. (amp 2009)
    389. Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate. (PubMed id 19541743)9 Sul H.S. (Mol. Endocrinol. 2009)
    390. The ADAM metalloproteinases. (PubMed id 18762209)9 Edwards D.R....Pennington C.J. (Mol. Aspects Med. 2008)
    391. Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach. (PubMed id 18822146)9 McEachin R.C....McInnis M.G. (BioData Min 2008)
    392. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. (PubMed id 18021299)9 Tachida Y....Hashimoto Y. (J. Neurochem. 2008)
    393. Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes. (PubMed id 18471442)9 Qureshi H.Y....Zafarullah M. (Biochim. Biophys. Acta 2008)
    394. Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes. (PubMed id 18239612)9 Kasamatsu S....Boissy R.E. (J. Invest. Dermatol. 2008)
    395. Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents. (PubMed id 18282708)9 Lu Z....Duan J.J. (amp 2008)
    396. mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. (PubMed id 18367087)9 Cho R.W....Worley P.F. (Neuron 2008)
    397. RNA interference silencing of DRAL affects processing of amyloid precursor protein. (PubMed id 18534756)9 Tanahashi H. and Yoshioka K. (Neurosci. Lett. 2008)
    398. Regulation of the receptor for TNFalpha, TNFR1, in human conjunctival epithelial cells. (PubMed id 18487372)9 Cook E.B....Barney N.P. (amp 2008)
    399. Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes. (PubMed id 17546624)9 El Mabrouk M....Zafarullah M. (J. Cell. Biochem. 2008)
    400. Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). (PubMed id 18234496)9 Ott G.R....Duan J.J. (amp 2008)
    401. PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid. (PubMed id 17986385)9 Holback S....Iverfeldt K. (Biochem. Biophys. Res. Commun. 2008)
    402. Role of metalloproteinases in platelet function. (PubMed id 17681591)9 Santos-MartA-nez M.J....Radomski M.W. (Thromb. Res. 2008)
    403. p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. (PubMed id 18390808)9 Deng X....Roth R.A. (J. Pharmacol. Exp. Ther. 2008)
    404. SEB-induced signaling in macrophages leads to biphasic TNF-alpha. (PubMed id 18364436)9 Khan A.A....Saha B. (J. Leukoc. Biol. 2008)
    405. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. (PubMed id 17283047)9 Chen J....Harris R.C. (Mol. Cell. Biol. 2007)
    406. Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor. (PubMed id 17169570)9 Hoth L.R....Geoghegan K.F. (Protein Expr. Purif. 2007)
    407. Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. (PubMed id 17504810)9 Wu S....Sears C.L. (J. Cell. Sci. 2007)
    408. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. (PubMed id 17945434)9 Peng Y....Lemere C.A. (Neuroscience 2007)
    409. Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. (PubMed id 17761766)9 Loesch K....Frank S.J. (Endocrinology 2007)
    410. The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription. (PubMed id 17600314)9 Kuwahara I....Kim K.C. (Am. J. Respir. Cell Mol. Biol. 2007)
    411. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. (PubMed id 17218812)9 Nadel J.A. (Curr Opin Allergy Clin Immunol 2007)
    412. Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding. (PubMed id 17545155)9 Zimina E.P.... Bruckner-Tuderman L. (J. Biol. Chem. 2007)
    413. Targeting TACE-dependent EGFR ligand shedding in breast cancer. (PubMed id 17218988)9 Kenny P.A. and Bissell M.J. (J. Clin. Invest. 2007)
    414. Regulation of interleukin-8 via an airway epithelial signaling cascade. (PubMed id 17220369)9 Nakanaga T....Shao M.X. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    415. ADAMs in cancer cell proliferation and progression. (PubMed id 17355265)9 Mochizuki S. and Okada Y. (Cancer Sci. 2007)
    416. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. (PubMed id 17548045)9 Moss M.L. and Rasmussen F.H. (Anal. Biochem. 2007)
    417. Emerging targets of biologic therapies for rheumatoid arthritis. (PubMed id 17538565)9 Tarner I.H....Gay S. (Nat Clin Pract Rheumatol 2007)
    418. Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. (PubMed id 17376651)9 Qureshi H.Y....Zafarullah M. (Cell. Signal. 2007)
    419. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. (PubMed id 17913923)9 Hoe H.S....Rebeck G.W. (J. Neurosci. 2007)
    420. Three-dimensional extracellular matrix culture models of EGFR signalling and drug response. (PubMed id 17635116)9 Kenny P.A. (Biochem. Soc. Trans. 2007)
    421. Evidence of a role of tumor necrosis factor alpha in refractory asthma. (PubMed id 16481637)9 Berry M.A....Pavord I.D. (N. Engl. J. Med. 2006)
    422. Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling? (PubMed id 16910760)9 Ungvari Z....Csiszar A. (amp 2006)
    423. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. (PubMed id 16229685)9 Stoeck A....Altevogt P. (Biochem. J. 2006)
    424. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. (PubMed id 16923819)9 Nishi E....Kita T. (J. Biol. Chem. 2006)
    425. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. (PubMed id 16806998)9 Wang C.T....Hou S.M. (Osteoarthr. Cartil. 2006)
    426. Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy. (PubMed id 16401770)9 Fedak P.W....Li R.K. (Circulation 2006)
    427. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. (PubMed id 16840716)9 Ohtsu H....Eguchi S. (Arterioscler. Thromb. Vasc. Biol. 2006)
    428. Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells. (PubMed id 16497166)9 Heidinger M....Ries C. (Biol. Chem. 2006)
    429. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. (PubMed id 16221845)9 LesnAc S....Buisson A. (J. Neurosci. 2005)
    430. Continuous real-time measurement of tumor necrosis factor-alpha converting enzyme activity on live cells. (PubMed id 16127421)9 Alvarez-Iglesias M....Takata M. ( a journal of technical methods and pathology 2005)
    431. Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation. (PubMed id 15913581)9 AnnAc W....HeidbA1chel H. (Cardiovasc. Res. 2005)
    432. TNFR1 upregulation mediates tolerance after brain ischemic preconditioning. (PubMed id 15647744)9 Pradillo J.M....Lizasoain I. (J. Cereb. Blood Flow Metab. 2005)
    433. Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs. (PubMed id 16378499)9 Le G.T. and Abbenante G. (Curr. Med. Chem. 2005)
    434. Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping. (PubMed id 16101009)9 Lambert M.H....Moss M.L. (amp 2005)
    435. Proteasome inhibition activates the transport and the ectodomain shedding of TNF-alpha receptors in human endothelial cells. (PubMed id 15731011)9 Peiretti F....Nalbone G. (J. Cell. Sci. 2005)
    436. Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. (PubMed id 15787600)9 Hooper N.M. (Biochem. Soc. Trans. 2005)
    437. The non-amyloidogenic pathway: structure and function of alpha-secretases. (PubMed id 15709475)9 Kojro E. and Fahrenholz F. (Subcell. Biochem. 2005)
    438. N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity. (PubMed id 15777285)9 Juanes P.P....Pandiella A. (Biochem. J. 2005)
    439. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. (PubMed id 15640347)9 Shao M.X. and Nadel J.A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    440. Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13. (PubMed id 15911259)9 Noe M.C....Tokar C. (amp 2005)
    441. Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch. (PubMed id 15581423)9 Leonard J.D....Milla M.E. (Biochem. J. 2005)
    442. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. (PubMed id 16002728)9 Bohlson S.S....Tenner A.J. (J. Immunol. 2005)
    443. Distinct roles of EGF repeats for the Notch signaling system. (PubMed id 15561108)9 Sakamoto K....Yamaguchi A. (Exp. Cell Res. 2005)
    444. Expression of TNFalpha and its receptors R1 and R2 in human alveolar epithelial cells exposed to organic dust and the effects of 8-bromo-cAMP and protein kinase A modulation. (PubMed id 16134057)9 Burvall K....Larsson K. (Inflamm. Res. 2005)
    445. Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme. (PubMed id 15713681)9 Lee M.H....Murphy G. (J. Biol. Chem. 2005)
    446. Screening of TACE peptide inhibitors from phage display peptide library. (PubMed id 16463648)9 Huang W....Yang Y. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2005)
    447. c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. (PubMed id 15887294)9 Edwards S.T....Fang K.C. (J. Pathol. 2005)

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    Entrez Gene: 6868 HGNC: 195 AceView: ADAM17 Ensembl:ENSG00000151694 euGenes: HUgn6868
    ECgene: ADAM17 Kegg: 6868 H-InvDB: ADAM17

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    PharmGKB entry for ADAM17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM17 Genetics and Cytogenetics in Oncology and Haematology

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    Search GeneIP for patents involving ADAM17

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     Browse compounds at ApexBio
     Addgene plasmids for ADAM17
      Search eBioscience for proteins for ADAM17
      Search eBioscience for elisas for ADAM17
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ADAM17
     antibodies-online antibodies for ADAM17 (173 products)
     antibodies-online kits for ADAM17 (22 products)
     antibodies-online peptides for ADAM17
     antibodies-online proteins for ADAM17 (10 products)
      GeneTex Antibodies for ADAM17: ADAM17 Antibodies
      Search GeneTex for Proteins for ADAM17
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