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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM17 Gene

protein-coding   GIFtS: 71
GCID: GC02M009580

ADAM Metallopeptidase Domain 17

(Previous names: tumor necrosis factor, alpha, converting enzyme)
(Previous symbol: TACE)
Microbiology & Infectious Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for ADAM17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 171 2     CD156B2
TACE1 2 3 5     NISBD2
Tumor Necrosis Factor, Alpha, Converting Enzyme1 2     ADAM Metallopeptidase Domain 182
Snake Venom-Like Protease2 3     Disintegrin And Metalloproteinase Domain-Containing Protein 172
CSVP2 3     TNF-Alpha Converting Enzyme2
TNF-Alpha Convertase2 3     ADAM 173
EC 3.4.24.863 8     CD156b Antigen3
ADAM182     TNF-Alpha-Converting Enzyme3

External Ids:    HGNC: 1951   Entrez Gene: 68682   Ensembl: ENSG000001516947   OMIM: 6036395   UniProtKB: P785363   

Export aliases for ADAM17 gene to outside databases

Previous GC identifers: GC02M009412 GC02M009680 GC02M009651


Summaries
for ADAM17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM17 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha
converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of
the Notch signaling pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM17 Gene: 
ADAM17 (ADAM metallopeptidase domain 17) is a protein-coding gene. Diseases associated with ADAM17 include neonatal inflammatory skin and bowel disease, and vitamin b12 deficiency, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Notch signaling pathway. GO annotations related to this gene include integrin binding and metalloendopeptidase activity. An important paralog of this gene is ADAM10.

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55
TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid
precursor protein. Also involved in the activation of Notch pathway (By similarity)

Gene Wiki entry for ADAM17 Gene


Genomic Views
for ADAM17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM17 gene promoter:
         Bach1   Elk-1   AML1a   HOXA3   IRF-1   c-Ets-1   Nkx6-1   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM17 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ADAM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM17 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009580:  view genomic region     (about GC identifiers)

Start:
 9,628,615 bp from pter      End:
 9,695,921 bp from pter
Size:
 67,307 bases      Orientation:
 minus strand

Proteins
for ADAM17 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 17 precursor  
Size: 824 amino acids; 93021 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with MAD2L1, MAPK14 and MUC1
Subcellular location: Membrane; Single-pass type I membrane protein
6/23 PDB 3D structures from and Proteopedia for ADAM17 (see all 23):
1BKC (3D)        1ZXC (3D)        2A8H (3D)        2DDF (3D)        2FV5 (3D)        2FV9 (3D)    
Secondary accessions: O60226
Alternative splicing: 2 isoforms:  P78536-1   P78536-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM17: NX_P78536

Explore proteomics data for ADAM17 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • UniProtKB: Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819
    but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated
    ectodomain shedding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78536

    • 3 DME Specific Peptides for ADAM17 (P78536)
     DGLAECA  CCKNCQF  LGLAYVGSPR 

    ADAM17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAM17 Protein Expression
    REFSEQ proteins: NP_003174.3  
    ENSEMBL proteins: 
     ENSP00000309968   ENSP00000418728  
    Reactome Protein details: P78536
    Human Recombinant Protein Products for ADAM17: 
    EMD Millipore Purified and/or Recombinant ADAM17 Protein
    R&D Systems Recombinant & Natural Proteins for ADAM17 (TACE/ADAM17)
    Enzo Life Sciences proteins for ADAM17
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADAM17
    GenScript Custom Purified and Recombinant Proteins Services for ADAM17
    Novus Biologicals ADAM17 Proteins
    Sino Biological Recombinant Protein for ADAM17
    Sino Biological Cell Lysate for ADAM17 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADAM17 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA17786981
    GO:0005911colocalizes with cell-cell junction IDA14970227
    GO:0005925colocalizes with focal adhesion IDA14970227

    ADAM17 for ontologies           About GeneDecksing



    ADAM17 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM17
    R&D Systems Antibodies for ADAM17 (TACE/ADAM17)
    Cell Signaling Technology (CST) Antibodies for ADAM17  (TACE)
    OriGene Antibodies for ADAM17
    OriGene Custom Antibody Services for ADAM17
    GenScript Custom Superior Antibodies Services for ADAM17
    Novus Biologicals ADAM17 Antibodies
    Abcam antibodies for ADAM17
    Cloud-Clone Corp. Antibodies for ADAM17 
    ThermoFisher Antibody for ADAM17
    LSBio Antibodies in human, mouse, rat for ADAM17 

    Assay Products for ADAM17: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADAM17
    R&D Systems ELISAs for ADAM17 (TACE/ADAM17)         (see all)
    GenScript Custom Assay Services for ADAM17
    Enzo Life Sciences assays for ADAM17
    Cloud-Clone Corp. ELISAs for ADAM17 
    Cloud-Clone Corp. CLIAs for ADAM17

    Protein Domains /
    Families
    for ADAM17 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CD: CD molecules
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM17 
    ADAM

    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry P78536

    ProtoNet protein and cluster: P78536

    2 Blocks protein domains:
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB001762 Disintegrin


    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Domain: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for
    the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM17 for domains           About GeneDecksing


    Function
    for ADAM17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA17_HUMAN, P78536
    Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
    proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
    several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55
    TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid
    precursor protein. Also involved in the activation of Notch pathway (By similarity)
    Catalytic activity: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in the
    membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other
    membrane-anchored, cell-surface proteins to 'shed' the extracellular domains
    Induction: In arthritis-affected cartilage

         Genatlas biochemistry entry for ADAM17:
    a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed in
    somatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP

         Enzyme Number (IUBMB): EC 3.4.24.861 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity TAS--
    GO:0005138interleukin-6 receptor binding IPI16034137
    GO:0005178integrin binding IPI14970227
    GO:0005515protein binding IPI10527948
    GO:0008237metallopeptidase activity TAS--
         
    ADAM17 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAM17:
     Increased viability after born  Stronger migration 

         15/20 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Adam17) (see all 20):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    ADAM17 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADAM17: Adam17tm1.1Bbl Adam17tm1Imx Adam17tm1.2Rain

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAM17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM17 

    miRNA
    Products:            		miRTarBase miRNAs that target ADAM17:
    hsa-mir-122 (MIRT003112)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM17
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM17 (see all 17):
    hsa-miR-140-3p hsa-miR-224 hsa-miR-148b hsa-miR-520d-5p hsa-miR-634 hsa-miR-767-5p hsa-miR-512-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM17 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADAM17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM17

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADAM17
    Sirion Biotech Customized adenovirus for overexpression of ADAM17

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADAM17 (see all 6)
    OriGene ORF clones in mouse, rat for ADAM17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183)
    Sino Biological Human cDNA Clone for ADAM17
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17
    Sirion Biotech Customized lentivirus for stable overexpression of ADAM17 
                         Customized lentivirus expression plasmids for stable overexpression of ADAM17 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ADAM17
    Search LifeMap BioReagents cell lines for ADAM17
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17


    Pathways & Interactions
    for ADAM17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAM17 About   (see all 37)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    		Signaling by NOTCH1 in Cancer0.79
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    		Signaling by NOTCH10.79
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    		Signaling by NOTCH0.74
    2Notch signaling pathway
    		Notch signaling pathway0.84
    		Delta-Notch Signaling Pathway0.33
    		Notch Signaling Pathway0.84
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Alzheimer's disease0.46
    		Alzheimers Disease0.44
    4Regulation by c-FLIP
    		Extrinsic Pathway for Apoptosis0.93
    		TNF signaling0.62
    		Death Receptor Signalling0.93
    5Signaling by FGFR
    		Signaling by EGFR0.84
    		Signalling by NGF0.71
    		Signaling by EGFR in Cancer0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ADAM17
        Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Notch Signaling Pathway
    Immune response IL-6 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    2 R&D Systems Pathways for ADAM17
        A-beta Plaque Formation & APP Metabolism
    Notch Signaling Pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADAM17 (see all 6)
        Notch Signaling
    Inhibition of Matrix Metalloproteinases
    Molecular Mechanisms of Cancer
    Alzheimers Disease Pathway
    Presenilin-Mediated Signaling

    2 Cell Signaling Technology (CST) Pathways for ADAM17
        Wnt / Hedgehog / Notch
    Neuroscience

    5 GeneGo (Thomson Reuters) Pathways for ADAM17
        Immune response IL-6 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Notch Signaling Pathway
    Development MAG-dependent inhibition of neurite outgrowth

    5/7 BioSystems Pathways for ADAM17 (see all 7)
        Notch Signaling Pathway
    BDNF signaling pathway
    Delta-Notch Signaling Pathway
    Alzheimers Disease
    ErbB4 signaling events

    1 Sino Biological Pathway for ADAM17 
        Notch Signaling Pathway

    5/33        Reactome Pathways for ADAM17 (see all 33)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by EGFR in Cancer
    Signaling by NOTCH1 in Cancer
    Death Receptor Signalling


    3         Kegg Pathways  (Kegg details for ADAM17):
        Notch signaling pathway
    Alzheimer's disease
    Epithelial cell signaling in Helicobacter pylori infection


    ADAM17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for ADAM17 (P785361, 2, 3 ENSP000003099684) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129592, 3, ENSP000003457314MINT-1901891 MINT-1901801 MINT-1901824 MINT-1901856 MINT-1901710 MINT-1901743 MINT-1901775 I2D: score=4 STRING: ENSP00000345731
    PTPN3P260452, 3, ENSP000002625394MINT-58311 MINT-58317 I2D: score=3 STRING: ENSP00000262539
    PDIA3P301012, 3MINT-4301309 I2D: score=1 
    TNFP013753, ENSP000003986984I2D: score=2 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=2 
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA18276953
    GO:0001934positive regulation of protein phosphorylation IMP18625725
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002467germinal center formation ISS10433800
    GO:0002690positive regulation of leukocyte chemotaxis IC16034137

    ADAM17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM17 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADAM17:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM17 (ADA17)

    8 DrugBank Compounds for ADAM17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid-- --target--10592235
    (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE-- --target--10592235
    (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL-- --target--10592235
    (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE-- --target--10592235
    3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol-- --target--10592235
    4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE-- --target--10592235
    N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan-- --target--10592235
    methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate-- --target--10592235

    10/37 Novoseek inferred chemical compound relationships for ADAM17 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adamalysin 84.6 3 12621058 (1), 10419777 (1)
    tapi 78.5 4 11106509 (1), 11156944 (1)
    hydroxamate 76.3 10 17368021 (1), 15284022 (1), 12723945 (1), 15128827 (1) (see all 7)
    (4-aminophenyl)mercuric acetate 70.7 2 18239612 (1), 15182369 (1)
    batimastat 70.4 4 15319441 (1), 9684866 (1), 10971741 (1), 12226103 (1)
    marimastat 58.1 4 10579851 (3), 12384559 (1)
    phorbol 50.3 3 10799547 (1), 15142990 (1), 19535569 (1)
    ag 1478 46.3 1 15319441 (1)
    phorbol-12-myristate 45.5 3 17942404 (1)
    zinc 40.1 24 15102849 (4), 15100227 (3), 10521439 (1), 17368021 (1) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about ADAM17 / ADA17

    Transcripts
    for ADAM17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM17 gene: 
    NM_003183.4  

    Unigene Cluster for ADAM17:

    ADAM metallopeptidase domain 17
    Hs.404914  [show with all ESTs]
    Unigene Representative Sequence: NM_003183
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310823(uc002qzu.3 uc010ewy.3 uc010ewz.3) ENST00000497134(uc010exa.3 uc010exb.1)
    ENST00000478059(uc002qzv.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM17 (see all 17):
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    Additional mRNA sequence: 

    AK289829.1 AY422721.1 BC062687.1 BC136783.1 BC146658.1 GQ402545.1 U69611.1 U69612.1 
    U86755.1 U92649.1 

    11 DOTS entries:

    DT.97840889  DT.101978379  DT.75154588  DT.91723298  DT.100737460  DT.91868817  DT.86857558  DT.100671075 
    DT.121006903  DT.121006944  DT.95089565 

    24/88 AceView cDNA sequences (see all 88):

    BM989580 AI075423 AI919444 BF059089 AW627690 AA933982 AI741293 AA827074 
    AA910834 BM827395 AI141532 AI141804 AI095477 BU734977 AI797833 CB159093 
    N27387 AW057613 AI911263 AY422721 NM_021832 BM705777 AA434423 AA377312 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                      -                                                                                                         
    SP2:                                                                                      -                                                         
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for ADAM17

    Expression
    for ADAM17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM17 expression in normal human tissues (normalized intensities)      ADAM17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAM17 Expression
    About this image


    ADAM17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Respiratory System)    fully expand to see all 4 entries
             bone marrow cd34+   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchoalveolar lavage cells   
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   

    See ADAM17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM17

    SOURCE GeneReport for Unigene cluster: Hs.404914

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle,
    pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADAM17: 
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              Multiple Sclerosis in human mouse rat
              Liver Cancer in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    Orthologs
    for ADAM17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAM17 gene from 14 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chimpanzee
    (Pan troglodytes)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 99.6(n)
    100(a)    		   459018  XM_515293.4  XP_515293.2 
    mouse
    (Mus musculus)    		 Mammalia Adam171 , 5 a disintegrin and metallopeptidase domain 171, 5 88.07(n)1
    92.11(a)1    		   12 (8.30 cM)5
    114911  NM_009615.51  NP_033745.41 
     213235095 
    rat
    (Rattus norvegicus)    		 Mammalia Adam171 ADAM metallopeptidase domain 17 88.03(n)
    92.48(a)    		   57027  NM_020306.1  NP_064702.1 
    cow
    (Bos taurus)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 88.28(n)
    92.94(a)    		   517541  XM_002691486.2  XP_002691532.1 
    dog
    (Canis familiaris)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 89.71(n)
    95.21(a)    		   475662  XM_532870.4  XP_532870.4 
    oppossum
    (Monodelphis domestica)    		 Mammalia ADAM176
    		 ADAM metallopeptidase domain 17
    		 85(a)
    		 1 ↔ 1
    		 1(530249276-530308357)
    platypus
    (Ornithorhynchus anatinus)    		 Mammalia --
    ox_plat1_1347216
    (see all 3)    		 Uncharacterized protein
    (see all 3)    		 91(a)
    88(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 Contig5134(2725-23644)
    Contig10465(491-10001)
    chicken
    (Gallus gallus)    		 Aves ADAM171 ADAM metallopeptidase domain 17 74.25(n)
    77.51(a)    		   421931  NM_001008682.1  NP_001008682.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM176
    		 Uncharacterized protein
    		 73(a)
    		 1 ↔ 1
    		 1(148417544-148444228)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc20b012 wufc20b01 75.1(n)   324142  BC057410.1 
    sea squirt
    (Ciona savignyi)    		 Ascidiacea --
    		 Uncharacterized protein
    		 36(a)
    		 1 ↔ 1
    		 reftig_17(463970-472793)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG79083
    Tace1    		 proteolysis and peptidolysis
    metalloendopeptidase3
    CG7908-PA1    		 41(a)3
    51.25(n)1
    44.87(a)1    		   99D13
    435581  NM_170455.21  NP_733334.11 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0023811 AGAP002381-PA 51.21(n)
    47.8(a)    		   1273579  XM_312572.4  XP_312572.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea adm-41 , 3 metalloprotease3
    Protein ADM-41    		 34(a)3
    48.39(n)1
    37.3(a)1    		   X(7830565-7833527)3
    1810411  NM_076917.21  NP_509318.11 
            Species with no ortholog for ADAM17

    ENSEMBL Gene Tree for ADAM17 (if available)
    TreeFam Gene Tree for ADAM17 (if available)

    Paralogs
    for ADAM17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM17 gene
    ADAM102  
    1 SIMAP similar gene for ADAM17 using alignment to 8 protein entries:     ADA17_HUMAN (see all proteins):
    ADAM22

    ADAM17 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1397 SNPs in ADAM17 are shown (see all 1397)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386269561,2
    		--9601091(+) TAATTC/TAAATA 1 -- ds50010--------
    rs1416991991,2
    		--9601136(+) TATCAA/CGTCTT 1 -- ds50010--------
    rs1462467971,2
    		--9601153(+) ACAGCC/TCCCAA 1 -- ds50010--------
    rs1845207381,2
    		--9601183(+) TCTATA/CTCCTG 1 -- ds50010--------
    rs2014492261,2
    		--9601221(+) TTTTT-/TTGTTTGT 1 -- cds10--------
    rs1387888491,2
    		C--9601234(+) TGTTG-/TTCTTGTT 1 -- cds10--------
    rs1874335891,2
    		--9601234(+) TTGTTC/GTTGTT 1 -- ds50010--------
    rs593173551,2
    		C--9601236(+) TTGTT-/CTTGTTAA 1 -- cds10--------
    rs1380953501,2
    		--9601248(+) AAATAC/TCTCAC 1 -- ds50010--------
    rs1417992821,2
    		C--9601263(+) TTATTC/TAATAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADAM17 (9628615 - 9695921 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADAM17: --

    Human Gene Mutation Database (HGMD): ADAM17
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ADAM17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 603639    OMIM disorders: --

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
  • Neonatal inflammatory skin and bowel disease (NISBD) [MIM:614328]: A disorder characterized by
    inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral
    and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules.
    Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal
    infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. Note=The
    disease is caused by mutations affecting the gene represented in this entry

    • 20/71 diseases for ADAM17 (see all 71):    About MalaCards
    neonatal inflammatory skin and bowel disease    vitamin b12 deficiency    renal osteodystrophy    chorioamnionitis
    differentiating neuroblastoma    severe acute respiratory syndrome    interstitial lung disease    acute myocardial infarction
    toxic shock syndrome    congestive heart failure    dilated cardiomyopathy    gastrointestinal stromal tumor
    pulmonary tuberculosis    myocarditis    abdominal aortic aneurysm    rabies
    osteoarthritis    pancreatic ductal adenocarcinoma    aortic aneurysm    cleft lip


    ADAM17 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for ADAM17 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 79.5 222 15206946 (4), 10521439 (2), 15075334 (2), 16737974 (2) (see all 99)
    tumors 63.1 208 15206946 (3), 17822026 (3), 17227756 (3), 10521439 (2) (see all 99)
    rheumatoid arthritis 43.1 8 14579524 (1), 14718605 (1), 12670535 (1), 20303413 (1) (see all 7)
    inflammation 34.7 14 12973924 (1), 19581416 (1), 20331435 (1), 17822026 (1) (see all 9)
    alzheimers disease 28.3 8 19234765 (3), 11032903 (2)
    arthritis 24.9 5 18471442 (1), 12463167 (1), 15859325 (1), 17376651 (1) (see all 5)
    senile plaques 23.4 1 11536196 (1)
    multiple sclerosis 15.9 5 16511637 (2), 19324423 (1), 12474981 (1), 15859325 (1)
    cancer 11.6 32 19843672 (5), 19408347 (2), 15309730 (1), 15197174 (1) (see all 10)
    osteoarthritis 5.26 6 9574564 (1), 14579524 (1), 10419777 (1), 11508576 (1)

    Genetic Association Database (GAD): ADAM17
    Human Genome Epidemiology (HuGE) Navigator: ADAM17 (16 documents)

    Export disorders for ADAM17 gene to outside databases

    Publications
    for ADAM17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM17 gene, integrated from 9 sources (see all 488):
    (articles sorted by number of sources associating them with ADAM17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PubMed id 9574564)1, 2, 3, 9 Patel I.R.... Amin A.R. (1998)
    2. A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PubMed id 9034190)1, 2, 3 Black R.A.... Cerretti D.P. (1997)
    3. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. (PubMed id 18600307)1, 4, 9 Morange P.E....Tiret L. (2008)
    4. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PubMed id 12621058)1, 2, 9 Fan H.... Derynck R. (2003)
    5. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PubMed id 9034191)1, 2, 9 Moss M.L.... Becherer J.D. (1997)
    6. Direct activation of TACE-mediated ectodomain sheddin g by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (2010)
    7. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. (PubMed id 9520379)1, 2, 9 Maskos K.... Bode W. (1998)
    8. Inflammatory skin and bowel disease linked to ADAM17 deletion. (PubMed id 22010916)1, 2 Blaydon D.C....Kelsell D.P. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Polymorphisms spanning the TNFR2 and TACE genes do no t contribute towards variable anti-TNF treatment response. (PubMed id 20300049)1, 4 Potter C....Barton A. (2010)

    External Searches for ADAM17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAM17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6868 HGNC: 195 AceView: ADAM17 Ensembl:ENSG00000151694 euGenes: HUgn6868
    ECgene: ADAM17 Kegg: 6868 H-InvDB: ADAM17

    Other Databases showing ADAM17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAM17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM17 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Tumor_Necrosis_Factor_Alpha_Converting_Enzyme

    Intellectual Property
    for ADAM17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM17 gene:
    Search GeneIP for patents involving ADAM17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAM17
    Customized:
     lentivirus for stable overexpression of ADAM17
     lentivirus expression plasmids for stable overexpression of ADAM17
     adenovirus for overexpression of ADAM17
     LSBio Antibodies in human, mouse, rat for ADAM17
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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