Aliases for ADAM17 Gene
Aliases for ADAM17 Gene
External Ids for ADAM17 Gene
- HGNC: 195
- Entrez Gene: 6868
- Ensembl: ENSG00000151694
- OMIM: 603639
- UniProtKB: P78536
Previous HGNC Symbols for ADAM17 Gene
- TACE
Previous GeneCards Identifiers for ADAM17 Gene
- GC02M009412
- GC02M009680
- GC02M009651
- GC02M009628
Summaries for ADAM17 Gene
-
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAM17 Gene
ADAM17 (ADAM Metallopeptidase Domain 17) is a Protein Coding gene. Diseases associated with ADAM17 include Inflammatory Skin And Bowel Disease, Neonatal, 1 and Neonatal Inflammatory Skin And Bowel Disease. Among its related pathways are Signaling by NOTCH1 and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM10.
UniProtKB/Swiss-Prot for ADAM17 Gene
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Additional gene information for ADAM17 Gene
- Monarch Initiative
- Search for ADAM17 at DataMed
- Search for ADAM17 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM17 Gene
Genomics for ADAM17 Gene
GeneHancer (GH) Regulatory Elements for ADAM17 Gene
Promoters and enhancers for ADAM17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADAM17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADAM17 Gene
Genomic Locations for ADAM17 Gene
- chr2:9,488,486-9,555,792
- (GRCh38/hg38)
- Size:
- 67,307 bases
- Orientation:
- Minus strand
- chr2:9,628,615-9,695,921
- (GRCh37/hg19)
Genomic View for ADAM17 Gene
Genes around ADAM17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p25.1 by Ensembl
- 2p25.1 by Entrez Gene
- 2p25.1 by HGNC
ADAM17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM17 Gene
Proteins for ADAM17 Gene
-
Protein details for ADAM17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78536-ADA17_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 17
- Protein Accession:
- P78536
- O60226
Protein attributes for ADAM17 Gene
- Size:
- 824 amino acids
- Molecular mass:
- 93021 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with MAD2L1, MAPK14 and MUC1.
Three dimensional structures from OCA and Proteopedia for ADAM17 Gene
Protein Expression for ADAM17 Gene
Selected DME Specific Peptides for ADAM17 Gene
- P78536:
-
- LGLAYVGSPR
- CCKNCQF
- DGLAECA
Post-translational modifications for ADAM17 Gene
- Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.
- The precursor is cleaved by a furin endopeptidase.
- Glycosylation at posLast=103103, posLast=157157, posLast=174174, posLast=264264, posLast=452452, Asn498, Asn539, posLast=551551, and posLast=594594
Other Protein References for ADAM17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ADAM17 (TACE/ADAM17)
- Cell Signaling Technology (CST) Antibodies for ADAM17 (TACE)
-
Custom Antibody ServicesOriGene Antibodies for ADAM17
- Novus Biologicals Antibodies for ADAM17
-
Abcam antibodies for ADAM17
-
Cloud-Clone Corp. Antibodies for ADAM17
- Invitrogen Antibodies for ADAM17
- antibodies-online: Search results for 273 available ADAM17 Antibodies ranked by validation data
- Compare Top ADAM17 Antibodies
-
Recommended
- 50 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 195 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 59 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex ADAM17 antibody for ADAM17
-
Custom Antibody ServicesProSci Antibodies for ADAM17
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM17
- Sino Biological Antibodies for ADAM17
Protein Products
- R&D Systems Proteins and Enzymes for ADAM17 (TACE/ADAM17)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADAM17
- Origene Custom Protein Services for ADAM17
- Novus Biologicals proteins for ADAM17
- Sino Biological Recombinant Proteins for ADAM17
- Sino Biological Cell Lysates for ADAM17
-
Cloud-Clone Corp. Proteins for ADAM17
- Search GeneTex for Proteins for ADAM17
-
Abcam proteins for ADAM17
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for ADAM17 (TACE/ADAM17)
-
Cloud-Clone Corp. Assay Kits for ADAM17
Domains & Families for ADAM17 Gene
Gene Families for ADAM17 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for ADAM17 Gene
Suggested Antigen Peptide Sequences for ADAM17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78536UniProtKB/Swiss-Prot:
ADA17_HUMAN :- Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).
- Domain:
-
- Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function for ADAM17 Gene
Molecular function for ADAM17 Gene
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed in somatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP
- UniProtKB/Swiss-Prot CatalyticActivity:
- Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to shed the extracellular domains.
- UniProtKB/Swiss-Prot Function:
- Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
- UniProtKB/Swiss-Prot Induction:
- In arthritis-affected cartilage.
Enzyme Numbers (IUBMB) for ADAM17 Gene
Phenotypes From GWAS Catalog for ADAM17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | TAS,IMP | -- |
| GO:0005112 | Notch binding | IDA | 24226769 |
| GO:0005138 | interleukin-6 receptor binding | IPI | 16034137 |
| GO:0005178 | integrin binding | IPI | 14970227 |
| GO:0005515 | protein binding | IPI | 10527948 |
Phenotypes for ADAM17 Gene
- MGI mutant phenotypes for ADAM17:
-
inferred from 15 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- pigmentation phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for ADAM17:
Animal Models for ADAM17 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADAM17
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAM17 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM17 gene
- Search ViGene Biosciences for ADAM17
CRISPR Products
- Browse CRISPR knockouts for ADAM17
- genomics-online: gRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- Applied Biological Materials CRISPR for ADAM17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM17
- GenScript: Design CRISPR guide RNA sequences for ADAM17
miRNA for ADAM17 Gene
- miRTarBase miRNAs that target ADAM17
-
- hsa-mir-122-5p (MIRT003112)
- hsa-mir-145-5p (MIRT007275)
- hsa-mir-152-3p (MIRT054717)
- hsa-mir-26a-5p (MIRT438130)
- hsa-mir-218-5p (MIRT441264)
- hsa-mir-5697 (MIRT503188)
- hsa-mir-6882-5p (MIRT503189)
- hsa-mir-26b-5p (MIRT503190)
- hsa-mir-1297 (MIRT503191)
- hsa-mir-4465 (MIRT503192)
- hsa-mir-6731-3p (MIRT624809)
- hsa-mir-548x-3p (MIRT624810)
- hsa-mir-548j-3p (MIRT624811)
- hsa-mir-548aq-3p (MIRT624812)
- hsa-mir-548am-3p (MIRT624813)
- hsa-mir-548aj-3p (MIRT624814)
- hsa-mir-548ah-3p (MIRT624815)
- hsa-mir-548ae-3p (MIRT624816)
- hsa-mir-5195-3p (MIRT624817)
- hsa-mir-129-5p (MIRT705916)
- hsa-mir-6842-3p (MIRT705917)
- hsa-mir-23c (MIRT705918)
- hsa-mir-23b-3p (MIRT705919)
- hsa-mir-23a-3p (MIRT705920)
- hsa-mir-130a-5p (MIRT705921)
- hsa-mir-5787 (MIRT705922)
- hsa-mir-4505 (MIRT705923)
- hsa-mir-3652 (MIRT705924)
- hsa-mir-4430 (MIRT705925)
- hsa-mir-4284 (MIRT705926)
- hsa-mir-24-3p (MIRT705927)
- hsa-mir-5580-5p (MIRT705928)
- hsa-mir-6504-5p (MIRT705929)
- hsa-mir-3064-5p (MIRT705930)
- hsa-mir-149-5p (MIRT705931)
- hsa-mir-548o-3p (MIRT705932)
- hsa-mir-1323 (MIRT705933)
- hsa-mir-4262 (MIRT705934)
- hsa-mir-181d-5p (MIRT705935)
- hsa-mir-181c-5p (MIRT705936)
- hsa-mir-181b-5p (MIRT705937)
- hsa-mir-181a-5p (MIRT705938)
- hsa-mir-649 (MIRT705939)
- hsa-mir-519e-5p (MIRT715592)
- hsa-mir-515-5p (MIRT715593)
- hsa-mir-6722-5p (MIRT715594)
- hsa-mir-5695 (MIRT715595)
- hsa-mir-519d-5p (MIRT715596)
- hsa-mir-3691-3p (MIRT715597)
- hsa-mir-512-3p (MIRT715598)
- hsa-mir-6877-3p (MIRT715599)
- hsa-mir-6819-3p (MIRT715600)
- hsa-mir-520e (MIRT715601)
- hsa-mir-520d-3p (MIRT715602)
- hsa-mir-520c-3p (MIRT715603)
- hsa-mir-520b (MIRT715604)
- hsa-mir-520a-3p (MIRT715605)
- hsa-mir-373-3p (MIRT715606)
- hsa-mir-372-3p (MIRT715607)
- hsa-mir-302e (MIRT715608)
- hsa-mir-302d-3p (MIRT715609)
- hsa-mir-302c-3p (MIRT715610)
- hsa-mir-302b-3p (MIRT715611)
- hsa-mir-302a-3p (MIRT715612)
- hsa-mir-338-3p (MIRT732080)
miRNA Products
- Search ViGene Biosciences for ADAM17
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ADAM17
- Browse OriGene Inhibitory RNA Products For ADAM17
- genomics-online: shRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM17 gene
Clone Products
- Sino Biological Human cDNA Clone for ADAM17
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADAM17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADAM17
- Applied Biological Materials Clones for ADAM17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAM17
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAM17 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAM17 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM17 gene
No data available for Transcription Factor Targets and HOMER Transcription for ADAM17 Gene
Localization for ADAM17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM17 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 3 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 25468996 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 17786981 |
| GO:0005911 | colocalizes_with cell-cell junction | IDA | 14970227 |
Pathways & Interactions for ADAM17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch signaling pathway (KEGG) |
.30
|
|
| 3 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 4 | Degradation of the extracellular matrix | ||
| 5 | TNF signaling (REACTOME) |
.86
|
|
Pathways by source for ADAM17 Gene
2 Sino Biological pathways for ADAM17 Gene
1 GeneTex pathway for ADAM17 Gene
2 Cell Signaling Technology pathways for ADAM17 Gene
8 BioSystems pathways for ADAM17 Gene
3 KEGG pathways for ADAM17 Gene
5 GeneGo (Thomson Reuters) pathways for ADAM17 Gene
3 R&D Systems pathways for ADAM17 Gene
6 Qiagen pathways for ADAM17 Gene
Interacting Proteins for ADAM17 Gene
Selected Interacting proteins:
ENSP00000309968
P78536-ADA17_HUMAN
for ADAM17 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for ADAM17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IDA | 18276953 |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 18625725 |
| GO:0002446 | neutrophil mediated immunity | IC | 16034137 |
| GO:0002467 | germinal center formation | ISS | 10433800 |
| GO:0002690 | positive regulation of leukocyte chemotaxis | IC | 16034137 |
Drugs & Compounds for ADAM17 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid | Experimental | Pharma | Target | 0 | ||
| (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE | Experimental | Pharma | Target | 0 | ||
| (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol | Experimental | Pharma | Target | 0 | ||
| (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | Experimental | Pharma | Target | 0 | ||
| 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ADAM17 Gene
| Compound | Action | Cas Number |
|---|---|---|
| TAPI-1 | TACE/ADAM17 inhibitor | 163847-77-6 |
Transcripts for ADAM17 Gene
mRNA/cDNA for ADAM17 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (88) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAM17 Gene
CRISPR Products
- Browse CRISPR knockouts for ADAM17
- genomics-online: gRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- Applied Biological Materials CRISPR for ADAM17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM17
- GenScript: Design CRISPR guide RNA sequences for ADAM17
miRNA Products
- Search ViGene Biosciences for ADAM17
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ADAM17
- Browse OriGene Inhibitory RNA Products For ADAM17
- genomics-online: shRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM17 gene
Clone Products
- Sino Biological Human cDNA Clone for ADAM17
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADAM17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADAM17
- Applied Biological Materials Clones for ADAM17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Expression for ADAM17 Gene
This gene is overexpressed in Bone (19.7), Amniocyte (11.7), Skin (6.7), and Testis (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAM17 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAM17 Gene:
ADAM17SOURCE GeneReport for Unigene cluster for ADAM17 Gene:
Hs.404914mRNA Expression by UniProt/SwissProt for ADAM17 Gene:
P78536-ADA17_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Evidence on tissue expression from TISSUES for ADAM17 Gene
- Liver(4.7)
- Blood(4.5)
- Lung(2.6)
- Nervous system(2.5)
- Heart(2.4)
- Intestine(2.4)
- Skin(2.3)
- Kidney(2.2)
- Lymph node(2.1)
- Spleen(2.1)
- Gall bladder(2)
- Muscle(2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM17 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
Organs:
Head and neck:
- brain
- ear
- eye
- eyelid
- face
- head
Thorax:
- esophagus
- heart
- lung
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- anus
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ADAM17
- genomics-online: primer clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ADAM17 Gene
Orthologs for ADAM17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAM17 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | ADAM17 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADAM17 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Adam17 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adam17 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADAM17 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAM17 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADAM17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adam17 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adam17b 33 34 |
|
||
| adam17a 34 |
|
OneToMany | |||
| wufc20b01 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Tace 33 34 |
|
||
| CG7908 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002381 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | adm-4 35 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for ADAM17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAM17 Gene
(1) SIMAP similar genes for ADAM17 Gene using alignment to 8 proteins:
Variants for ADAM17 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs146893995 | likely-benign, Inflammatory skin and bowel disease, neonatal 1 | 9,523,315(-) | A/G | 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant | |
| rs2230818 | benign, Inflammatory skin and bowel disease, neonatal 1 | 9,527,801(-) | T/A/C | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, stop_gained | |
| rs387906866 | pathogenic, Inflammatory skin and bowel disease, neonatal 1 | 9,527,799(-) | TCTGTCT/TCT | 5_prime_UTR_variant, coding_sequence_variant, frameshift, genic_upstream_transcript_variant | |
| rs554069834 | uncertain-significance, Inflammatory skin and bowel disease, neonatal 1 | 9,505,179(-) | C/T | coding_sequence_variant, missense_variant | |
| rs56237316 | benign, Inflammatory skin and bowel disease, neonatal 1 | 9,497,202(-) | A/G/T | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM17 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM17 Gene
Disorders for ADAM17 Gene
(23) MalaCards diseases for ADAM17 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory skin and bowel disease, neonatal, 1 |
|
|
| neonatal inflammatory skin and bowel disease |
|
|
| pulmonary embolism and infarction |
|
|
| gastrointestinal system cancer |
|
|
| hepatic vascular disease |
|
|
Search ADAM17 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADA17_HUMAN- Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) [MIM:614328]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. {ECO:0000269 PubMed:22010916}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ADAM17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ADAM17 Gene
Publications for ADAM17 Gene
- TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PMID: 9574564) Patel IR … Amin AR (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4 22 58
- Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. (PMID: 18600307) Morange PE … Tiret L (Journal of molecular medicine (Berlin, Germany) 2008) 3 22 44 58
- Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PMID: 12621058) Fan H … Derynck R (The Journal of biological chemistry 2003) 3 4 22 58
- A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. (PMID: 9034190) Black RA … Cerretti DP (Nature 1997) 2 3 4 58
- TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. (PMID: 24227843) Heurich A … Pöhlmann S (Journal of virology 2014) 3 4 58
Products for ADAM17 Gene
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- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ADAM17 (TACE/ADAM17)
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ADAM17
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ADAM17
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADAM17
- VectorBuilder custom plasmid, inducible vectors for ADAM17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADAM17
- antibodies-online: Search results for 273 available ADAM17 Antibodies ranked by validation data
- Compare Top ADAM17 Antibodies
- Recommended
- 50 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 195 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 59 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 34 available ADAM17 Elisa Kits ranked by validation data
- Compare Top ADAM17 Elisa Kits
- antibodies-online: Search results for 17 available ADAM17 Proteins ranked by validation data
- Compare Top ADAM17 Proteins
- GeneTex ADAM17 antibody for ADAM17
- Search GeneTex for Proteins for ADAM17
- ViGene Biosciences adenoviral particle packaged cDNA for ADAM17 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ADAM17 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ADAM17 gene
- Search ViGene Biosciences for ADAM17
- Santa Cruz Biotechnology (SCBT) Antibodies for ADAM17
- Search Santa Cruz Biotechnology (SCBT) for ADAM17 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADAM17
- Custom Antibody ServicesProSci Antibodies for ADAM17
- Horizon Cell Lines for ADAM17
- genomics-online: cdna clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- orf clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- genomics-online: gRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- genomics-online: primer clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
- genomics-online: shRNA clones - Search results for 107 available ADAM17 gene related products
- Overview of 107 available ADAM17 gene related products
Sources for ADAM17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew