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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM17 Gene

protein-coding   GIFtS: 67
GCID: GC02M009580

ADAM metallopeptidase domain 17

(Previous names: tumor necrosis factor, alpha, converting enzyme )
(Previous symbol: TACE)
 Explore 73 diseases affiliated with
ADAM17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAM17    

Aliases
for ADAM17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 171 2     ADAM182
TACE1 2 3 5     NISBD2
CD156B1 2     ADAM Metallopeptidase Domain 182
Tumor Necrosis Factor, Alpha, Converting Enzyme1 2     Disintegrin And Metalloproteinase Domain-Containing Protein 172
Snake Venom-Like Protease2 3     TNF-Alpha Converting Enzyme2
CSVP2 3     ADAM 173
TNF-Alpha Convertase2 3     CD156b Antigen3
EC 3.4.24.863 8     TNF-Alpha-Converting Enzyme3
CSVP2 3     

External Ids:    HGNC: 1951   Entrez Gene: 68682   Ensembl: ENSG000001516947   OMIM: 6036395   UniProtKB: P785363   

Export aliases for ADAM17 gene to outside databases

Previous GC identifers: GC02M009412 GC02M009680 GC02M009651


Summaries
for ADAM17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM17:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and
neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds
mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor,
transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also
involved in the activation of Notch pathway (By similarity)

Gene Wiki entry for ADAM17


Genomic Views
for ADAM17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM17 gene promoter:
         Bach1   Elk-1   AML1a   HOXA3   IRF-1   c-Ets-1   Nkx6-1   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM17 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ADAM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM17 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009580:  view genomic region     (about GC identifiers)

Start:
 9,628,615 bp from pter      End:
 9,695,921 bp from pter
Size:
 67,307 bases      Orientation:
 minus strand

Proteins
for ADAM17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 17 precursor  
Size: 824 amino acids; 93021 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with MAD2L1, MAPK14 and MUC1
Subcellular location: Membrane; Single-pass type I membrane protein
6/22 PDB 3D structures from and Proteopedia for ADAM17 (see all 22):
1BKC (3D)        1ZXC (3D)        2A8H (3D)        2DDF (3D)        2FV5 (3D)        2FV9 (3D)    
Secondary accessions: O60226
Alternative splicing: 2 isoforms:  P78536-1   P78536-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM17: NX_P78536

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but
    • decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain
    shedding1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78536

    • 3 DME Specific Peptides for ADAM17 (P78536)
     DGLAECA  CCKNCQF  LGLAYVGSPR 

    ADAM17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003174.3  
    ENSEMBL proteins: 
     ENSP00000309968   ENSP00000418728  
    Reactome Protein details: P78536
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ADAM17 Protein
    R&D Systems Recombinant & Natural Proteins for ADAM17 (TACE/ADAM17)
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    Novus Biologicals ADAM17 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAM17

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA17786981
    GO:0005911colocalizes with cell-cell junction IDA14970227
    GO:0005925colocalizes with focal adhesion IDA14970227


    ADAM17 for ontologies           About GeneDecksing



    ADAM17 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADAM17
    R&D Systems Antibodies for ADAM17 (TACE/ADAM17)
    Cell Signaling Technology (CST) Antibodies for ADAM17  (TACE)
    OriGene Antibodies (see all 2): ADAM17
    OriGene Custom Antibody Services for ADAM17 
    GenScript Custom Superior Antibodies Services for ADAM17
    Novus Biologicals ADAM17 Antibodies
    Search for Antibodies for ADAM17 at Abcam  
    Uscn Antibodies for ADAM17
    ThermoFisher Antibodies for ADAM17

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    Enzo Life Sciences assays for ADAM17
    Uscn ELISAs and CLIAs for ADAM17

    Protein Domains /
    Families
    for ADAM17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM17 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry P78536

    ProtoNet protein and cluster: P78536

    2 Blocks protein families:
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB001762 Disintegrin


    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Domain: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the
    this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAM17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the
    proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of
    several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor,
    transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also
    involved in the activation of Notch pathway (By similarity)
    Catalytic activity: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in the
    membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored,
    cell-surface proteins to 'shed' the extracellular domains
    Induction: In arthritis-affected cartilage

         Genatlas biochemistry entry for ADAM17:
    a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed in
    somatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP

    Enzyme Number (IUBMB): EC 3.4.24.861 2

    miRNA
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    hsa-mir-122 (MIRT003112)

    OriGene 3'-UTR Clone: ADAM17
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM17
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM17 (see all 17):
    hsa-miR-140-3p hsa-miR-224 hsa-miR-148b hsa-miR-520d-5p hsa-miR-634 hsa-miR-767-5p hsa-miR-512-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM17 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM17 (see all 7)
    OriGene shRNA RFP: ADAM17
    OriGene siRNA: ADAM17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM17

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADAM17

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity TAS--
    GO:0005138interleukin-6 receptor binding IPI16034137
    GO:0005178integrin binding IPI14970227
    GO:0005515protein binding IPI10527948
    GO:0008237metallopeptidase activity TAS--


    ADAM17 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ADAM17:
     Increased viability after born  Stronger migration 

    Animal Models:
         Mouse knock-outs for ADAM17: Adam17tm1.1Bbl Adam17tm1Imx
         15/20 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Adam17) (see all 20):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    ADAM17 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAM17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/11 pathways (see all 11)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.71
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    		Constitutive Signaling by NOTCH1 HD Domain Mutants0.62
    		Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor0.43
    		Activated NOTCH1 Transmits Signal to the Nucleus0.58
    		Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant0.24
    3Development_CNTF receptor signaling
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Immune response_IL-6 signaling pathway0.30
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Immune response IL-6 signaling pathway0.30
    4Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Delta-Notch Signaling Pathway0.27
    		Notch signaling pathway0.82
    5Signaling by FGFR
    		Signaling by EGFR0.84
    		Signalling by NGF0.52
    		Signaling by EGFR in Cancer0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for ADAM17
        Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Notch Signaling Pathway
    Immune response IL-6 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADAM17 (see all 6)
        Notch Signaling
    Inhibition of Matrix Metalloproteinases
    Molecular Mechanisms of Cancer
    Alzheimers Disease Pathway
    Presenilin-Mediated Signaling

    2 Cell Signaling Technology (CST) Pathways for ADAM17
        Wnt / Hedgehog / Notch
    Neuroscience

    5 GeneGo (Thomson Reuters) Pathways for ADAM17
        Immune response IL-6 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Notch Signaling Pathway
    Development MAG-dependent inhibition of neurite outgrowth

    5/6 BioSystems Pathways for ADAM17 (see all 6) 
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Alzheimers Disease
    TNF receptor signaling pathway
    ErbB4 signaling events

    5/29        Reactome Pathways for ADAM17 (see all 29)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by EGFR in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer


    3         Kegg Pathways  (Kegg details for ADAM17):
        Notch signaling pathway
    Alzheimer's disease
    Epithelial cell signaling in Helicobacter pylori infection


    ADAM17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for ADAM17 (P785361, 2, 3 ENSP000003099684) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129592, 3, ENSP000003457314MINT-1901891 MINT-1901801 MINT-1901824 MINT-1901856 MINT-1901710 MINT-1901743 MINT-1901775 I2D: score=4 STRING: ENSP00000345731
    PTPN3P260452, 3, ENSP000002625394MINT-58311 MINT-58317 I2D: score=3 STRING: ENSP00000262539
    PDIA3P301012, 3MINT-4301309 I2D: score=1 
    MAD2L1Q132571, 2, 3, ENSP000002965094EBI-78188,EBI-78203 MINT-13999 MINT-13998 I2D: score=6 STRING: ENSP00000296509
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA18276953
    GO:0001934positive regulation of protein phosphorylation IMP18625725
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002467germinal center formation ISS10433800
    GO:0002690positive regulation of leukocyte chemotaxis IC16034137


    ADAM17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM17 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADAM17:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM17

    8 DrugBank Compounds for ADAM17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid-- --target--10592235
    (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE-- --target--10592235
    (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL-- --target--10592235
    (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE-- --target--10592235
    3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol-- --target--10592235
    4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE-- --target--10592235
    N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan-- --target--10592235
    methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate-- --target--10592235

    10/37 Novoseek chemical compound relationships for ADAM17 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adamalysin 84.6 3 12621058 (1), 10419777 (1)
    tapi 78.5 4 11106509 (1), 11156944 (1)
    hydroxamate 76.3 10 17368021 (1), 15284022 (1), 12723945 (1), 15128827 (1) (see all 7)
    (4-aminophenyl)mercuric acetate 70.7 2 18239612 (1), 15182369 (1)
    batimastat 70.4 4 15319441 (1), 9684866 (1), 10971741 (1), 12226103 (1)
    marimastat 58.1 4 10579851 (3), 12384559 (1)
    phorbol 50.3 3 10799547 (1), 15142990 (1), 19535569 (1)
    ag 1478 46.3 1 15319441 (1)
    phorbol-12-myristate 45.5 3 17942404 (1)
    zinc 40.1 24 15102849 (4), 15100227 (3), 10521439 (1), 17368021 (1) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about ADAM17 / ADA17 

    Transcripts
    for ADAM17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM17 gene: 
    NM_003183.4  

    Unigene Cluster for ADAM17:

    ADAM metallopeptidase domain 17
    Hs.404914  [show with all ESTs]
    Unigene Representative Sequence: NM_003183
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310823(uc002qzu.3 uc010ewy.3 uc010ewz.3) ENST00000497134(uc010exa.3 uc010exb.1)
    ENST00000478059(uc002qzv.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ADAM17
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM17
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM17 (see all 17):
    hsa-miR-140-3p hsa-miR-224 hsa-miR-148b hsa-miR-520d-5p hsa-miR-634 hsa-miR-767-5p hsa-miR-512-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM17 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM17 (see all 7)
    OriGene shRNA RFP: ADAM17
    OriGene siRNA: ADAM17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM17
    Clone
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    Additional cDNA sequence: 

    AK289829.1 AY422721.1 BC062687.1 BC136783.1 BC146658.1 GQ402545.1 U69611.1 U69612.1 
    U86755.1 U92649.1 

    11 DOTS entries:

    DT.97840889  DT.101978379  DT.75154588  DT.91723298  DT.100737460  DT.91868817  DT.86857558  DT.100671075 
    DT.121006903  DT.121006944  DT.95089565 

    24/88 AceView cDNA sequences (see all 88):

    AI919444 AI741293 AA933982 AI911263 AI095477 AI075423 AI141532 N27387 
    CB159093 AA827074 BF059089 BM827395 AA910834 AW627690 BM989580 AI797833 
    AI141804 BU734977 AW057613 AA811251 BE645266 NM_021832 AI910050 AY422721 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                      -                                                                                                         
    SP2:                                                                                      -                                                         
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for ADAM17

    Expression
    for ADAM17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ADAM17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM17

    SOURCE GeneReport for Unigene cluster: Hs.404914

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
    Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle,
    pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADAM17: 
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              Multiple Sclerosis in human mouse rat
              Liver Cancer in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for ADAM17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADAM17 gene from 21 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chimpanzee
    (Pan troglodytes)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 99.6(n)
    100(a)    		   459018  XM_515293.4  XP_515293.2 
    mouse
    (Mus musculus)    		 Mammalia Adam171 , 5 a disintegrin and metallopeptidase domain 171, 5 88.07(n)1
    92.11(a)1    		   12 (8.30 cM)5
    114911  NM_009615.51  NP_033745.41 
     213235095 
    rat
    (Rattus norvegicus)    		 Mammalia Adam171 ADAM metallopeptidase domain 17 88.03(n)
    92.48(a)    		   57027  NM_020306.1  NP_064702.1 
    cow
    (Bos taurus)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 88.28(n)
    92.94(a)    		   517541  XM_002691486.2  XP_002691532.1 
    dog
    (Canis familiaris)    		 Mammalia ADAM171 ADAM metallopeptidase domain 17 89.71(n)
    95.21(a)    		   475662  XM_532870.4  XP_532870.4 
    oppossum
    (Monodelphis domestica)    		 Mammalia ADAM176
    		 Uncharacterized protein
    		 85(a)
    		 1 ↔ 1
    		 1(530249276-530308357)
    platypus
    (Ornithorhynchus anatinus)    		 Mammalia ADAM176
    		 Uncharacterized protein
    		 91(a)
    		 1 ↔ 1
    		 Contig5134(2725-23644)
    chicken
    (Gallus gallus)    		 Aves ADAM171 ADAM metallopeptidase domain 17 74.25(n)
    77.51(a)    		   421931  NM_001008682.1  NP_001008682.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM176
    		 --
    		 73(a)
    		 1 ↔ 1
    		 1(148417544-148444228)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc20b012 wufc20b01 75.1(n)   324142  BC057410.1 
    sea squirt
    (Ciona savignyi)    		 Ascidiacea --
    		 --
    		 37(a)
    		 1 ↔ 1
    		 reftig_17(463970-472793)
    sea urchin
    (Strongylocentrotus purpuratus)    		 Echinoidea --
    --
    		 --
    		 43(a)
    40(a)
    		 1 ↔ many
    1 ↔ many
    		 scaffold_1050(129127-147839)
    scaffold_1050(124134-136944)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG79083
    Tace1    		 proteolysis and peptidolysis
    metalloendopeptidase3
    CG7908-PA1    		 41(a)3
    51.25(n)1
    44.87(a)1    		   99D13
    435581  NM_170455.21  NP_733334.11 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0023811 AGAP002381-PA 51.21(n)
    47.8(a)    		   1273579  XM_312572.4  XP_312572.4 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 40(a)
    		 1 ↔ 1
    		 Group4.19(632586-636506)
    worm
    (Caenorhabditis elegans)    		 Secernentea adm-41 , 3 metalloprotease3
    Protein ADM-41    		 34(a)3
    48.39(n)1
    37.3(a)1    		   X(7830565-7833527)3
    1810411  NM_076917.21  NP_509318.11 
    schistosome parasite
    (Schistosoma mansoni)    		 Trematoda Smp_1753406
    		 ADAM17 peptidase (M12 family)
    		 26(a)
    		 1 ↔ 1
    		 Smp_scaff000600(35234-49175)
    common water flea
    (Daphnia pulex)    		 Crustacea --
    		 --
    		 39(a)
    		 1 ↔ 1
    		 scaffold_11(714287-717644)
    Trichoplax
    (Trichoplax adhaerens)    		 Tricoplacia --
    --
    		 --
    		 34(a)
    14(a)
    		 1 ↔ 1
    possible ortholog
    		 scaffold_9(1719261-1727998)
    scaffold_5(4111503-4114849)
    sea anemone
    (Nematostella vectensis)    		 Anthozoa --
    		 --
    		 24(a)
    		 possible ortholog
    		 scaffold_27(1250282-1253789)
    stem rust fungus
    (Puccinia graminis)    		 Pucciniomycetes PGTG_007456
    PGTG_121836
    		 hypothetical protein
    		 13(a)
    11(a)
    		 many ↔ many
    many ↔ many
            Species with no ortholog for ADAM17

    ENSEMBL Gene Tree for ADAM17 (if available)
    TreeFam Gene Tree for ADAM17 (if available) 

    Paralogs
    for ADAM17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM17 gene
    ADAM102  
    1 SIMAP similar gene for ADAM17 using alignment to 8 protein entries:     ADA17_HUMAN (see all proteins):
    ADAM22

    ADAM17 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1128 NCBI SNPs in ADAM17 are shown (see all 1128)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386269561,2
    		--9629155(+) TAATTC/TAAATA 1 -- ds50010--------
    rs1416991991,2
    		--9629200(+) TATCAA/CGTCTT 1 -- ds50010--------
    rs1462467971,2
    		--9629217(+) ACAGCC/TCCCAA 1 -- ds50010--------
    rs1845207381,2
    		--9629247(+) TCTATA/CTCCTG 1 -- ds50010--------
    rs2014492261,2
    		--9629285(+) TTTTT-/TTGTTTGT 1 -- ds50010--------
    rs1387888491,2
    		C,--9629298(+) TGTTG-/TTCTTGTT 1 -- ds50010--------
    rs1874335891,2
    		--9629298(+) TTGTTC/GTTGTT 1 -- ds50010--------
    rs1380953501,2
    		--9629312(+) AAATAC/TCTCAC 1 -- ds50010--------
    rs1417992821,2
    		--9629327(+) TTATTC/TAATAG 1 -- ds50010--------
    rs1505966401,2
    		--9629328(+) TATTCA/GATAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADAM17 (9628615 - 9695921 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADAM17: --
    Human Gene Mutation Database (HGMD): ADAM17

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    Disorders / Diseases
    for ADAM17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM17 for disorders           About GeneDecksing

    OMIM gene information: 603639    OMIM disorders: --

    UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
  • Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:614328]. NISBD is a
    • disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin
    lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and
    widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent
    gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized

    20/73 diseases for ADAM17 (see all 73):    About MalaCards
    cleft lip/palate    abdominal aortic aneurysm    acute myocardial infarction    cleft lip
    severe acute respiratory syndrome    aortic aneurysm    inflammatory bowel disease    myocardial infarction
    congestive heart failure    gastrointestinal stromal tumor    dilated cardiomyopathy    amyotrophic lateral sclerosis
    oral squamous cell carcinoma    renal osteodystrophy    lateral sclerosis    squamous cell carcinoma
    differentiating neuroblastoma    pancreatic ductal adenocarcinoma    interstitial lung disease    rheumatoid arthritis

    10/27 Novoseek disease relationships for ADAM17 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 79.5 222 15206946 (4), 10521439 (2), 15075334 (2), 16737974 (2) (see all 99)
    tumors 63.1 208 15206946 (3), 17822026 (3), 17227756 (3), 10521439 (2) (see all 99)
    rheumatoid arthritis 43.1 8 14579524 (1), 14718605 (1), 12670535 (1), 20303413 (1) (see all 7)
    inflammation 34.7 14 12973924 (1), 19581416 (1), 20331435 (1), 17822026 (1) (see all 9)
    alzheimers disease 28.3 8 19234765 (3), 11032903 (2)
    arthritis 24.9 5 18471442 (1), 12463167 (1), 15859325 (1), 17376651 (1) (see all 5)
    senile plaques 23.4 1 11536196 (1)
    multiple sclerosis 15.9 5 16511637 (2), 19324423 (1), 12474981 (1), 15859325 (1)
    cancer 11.6 32 19843672 (5), 19408347 (2), 15309730 (1), 15197174 (1) (see all 10)
    osteoarthritis 5.26 6 9574564 (1), 14579524 (1), 10419777 (1), 11508576 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADAM17 (16 documents)

    Export disorders for ADAM17 gene to outside databases

    Publications
    for ADAM17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM17 gene, integrated from 9 sources (see all 467):
    (articles sorted by number of sources associating them with ADAM17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PubMed id 9574564)1, 2, 3, 9 Patel I.R.... Amin A.R. (1998)
    2. A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PubMed id 9034190)1, 2, 3 Black R.A.... Cerretti D.P. (1997)
    3. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PubMed id 12621058)1, 2, 9 Fan H.... Derynck R. (2003)
    4. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PubMed id 9034191)1, 2, 9 Moss M.L.... Becherer J.D. (1997)
    5. Direct activation of TACE-mediated ectodomain sheddin g by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (2010)
    6. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. (PubMed id 9520379)1, 2, 9 Maskos K.... Bode W. (1998)
    7. Inflammatory skin and bowel disease linked to ADAM17 deletion. (PubMed id 22010916)1, 2 Blaydon D.C....Kelsell D.P. (2011)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. (PubMed id 12441351)1, 2 Thathiah A.... Carson D.D. (2003)
    10. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. (PubMed id 12058067)1, 2 Diaz-Rodriguez E....Pandiella A. (2002)

    External Searches for ADAM17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADAM17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6868 HGNC: 195 AceView: ADAM17 Ensembl:ENSG00000151694 euGenes: HUgn6868
    ECgene: ADAM17 Kegg: 6868 H-InvDB: ADAM17

    Other Databases showing ADAM17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADAM17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM17 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Tumor_Necrosis_Factor_Alpha_Converting_Enzyme

    Intellectual Property
    for ADAM17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM17 gene:
    Search GeneIP for patents involving ADAM17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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