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Aliases for ADAM17 Gene

Aliases for ADAM17 Gene

  • ADAM Metallopeptidase Domain 17 2 3
  • TACE 3 4 6
  • Tumor Necrosis Factor, Alpha, Converting Enzyme 2 3
  • Snake Venom-Like Protease 3 4
  • TNF-Alpha Convertase 3 4
  • EC 3.4.24.86 4 63
  • NISBD 3 6
  • CSVP 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 17 3
  • ADAM Metallopeptidase Domain 18 3
  • TNF-Alpha Converting Enzyme 3
  • TNF-Alpha-Converting Enzyme 4
  • CD156b Antigen 4
  • ADAM 17 4
  • ADAM18 3
  • CD156B 3
  • NISBD1 3

External Ids for ADAM17 Gene

Previous HGNC Symbols for ADAM17 Gene

  • TACE

Previous GeneCards Identifiers for ADAM17 Gene

  • GC02M009412
  • GC02M009680
  • GC02M009651
  • GC02M009628

Summaries for ADAM17 Gene

Entrez Gene Summary for ADAM17 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM17 Gene

ADAM17 (ADAM Metallopeptidase Domain 17) is a Protein Coding gene. Diseases associated with ADAM17 include inflammatory skin and bowel disease, neonatal, 1 and neonatal inflammatory skin and bowel disease. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM10.

UniProtKB/Swiss-Prot for ADAM17 Gene

  • Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

Gene Wiki entry for ADAM17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM17 Gene

Genomics for ADAM17 Gene

Regulatory Elements for ADAM17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAM17 Gene

Start:
9,488,486 bp from pter
End:
9,555,792 bp from pter
Size:
67,307 bases
Orientation:
Minus strand

Genomic View for ADAM17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM17 Gene

Proteins for ADAM17 Gene

  • Protein details for ADAM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78536-ADA17_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 17
    Protein Accession:
    P78536
    Secondary Accessions:
    • O60226

    Protein attributes for ADAM17 Gene

    Size:
    824 amino acids
    Molecular mass:
    93021 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with MAD2L1, MAPK14 and MUC1.

    Three dimensional structures from OCA and Proteopedia for ADAM17 Gene

    Alternative splice isoforms for ADAM17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM17 Gene

Proteomics data for ADAM17 Gene at MOPED

Selected DME Specific Peptides for ADAM17 Gene

Post-translational modifications for ADAM17 Gene

  • Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.
  • The precursor is cleaved by a furin endopeptidase.
  • Ubiquitination at Lys728
  • Glycosylation at Asn103, Asn157, Asn174, Asn264, Asn452, Asn498, Asn539, Asn551, and Asn594
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM17 (TACE)

Protein Products

  • Enzo Life Sciences proteins for ADAM17

Domains for ADAM17 Gene

Gene Families for ADAM17 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
  • CD :CD molecules
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM17 Gene

Graphical View of Domain Structure for InterPro Entry

P78536

UniProtKB/Swiss-Prot:

ADA17_HUMAN :
  • P78536
Domain:
  • Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM17: view

Function for ADAM17 Gene

Molecular function for ADAM17 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed in somatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP
UniProtKB/Swiss-Prot CatalyticActivity:
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to shed the extracellular domains
UniProtKB/Swiss-Prot Function:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
UniProtKB/Swiss-Prot Induction:
In arthritis-affected cartilage

Enzyme Numbers (IUBMB) for ADAM17 Gene

Gene Ontology (GO) - Molecular Function for ADAM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0005112 Notch binding IDA 24226769
GO:0005138 interleukin-6 receptor binding IPI 16034137
GO:0005178 integrin binding IPI 14970227
GO:0005515 protein binding IPI 10527948
genes like me logo Genes that share ontologies with ADAM17: view
genes like me logo Genes that share phenotypes with ADAM17: view

Animal Models for ADAM17 Gene

MGI Knock Outs for ADAM17:

Animal Model Products

CRISPR Products

miRNA for ADAM17 Gene

miRTarBase miRNAs that target ADAM17

No data available for Transcription Factor Targeting and HOMER Transcription for ADAM17 Gene

Localization for ADAM17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM17 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM17 Gene COMPARTMENTS Subcellular localization image for ADAM17 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
cytosol 2
extracellular 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 17786981
GO:0005911 colocalizes_with cell-cell junction IDA 14970227
GO:0005925 colocalizes_with focal adhesion IDA 14970227
genes like me logo Genes that share ontologies with ADAM17: view

Pathways for ADAM17 Gene

genes like me logo Genes that share pathways with ADAM17: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ADAM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 18276953
GO:0001934 positive regulation of protein phosphorylation IMP 18625725
GO:0002446 neutrophil mediated immunity IC 16034137
GO:0002467 germinal center formation ISS 10433800
GO:0002690 positive regulation of leukocyte chemotaxis IC 16034137
genes like me logo Genes that share ontologies with ADAM17: view

Compounds for ADAM17 Gene

Compound Products

(1) ApexBio Compounds for ADAM17 Gene

Compound Action Cas Number
TAPI-1 TACE/ADAM17 inhibitor [163847-77-6]

(37) Novoseek inferred chemical compound relationships for ADAM17 Gene

Compound -log(P) Hits PubMed IDs
adamalysin 84.6 2
tapi 78.5 2
hydroxamate 76.3 7
(4-aminophenyl)mercuric acetate 70.7 2
batimastat 70.4 4
genes like me logo Genes that share compounds with ADAM17: view

Transcripts for ADAM17 Gene

Unigene Clusters for ADAM17 Gene

ADAM metallopeptidase domain 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM17

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for ADAM17 Gene

GeneLoc Exon Structure for
ADAM17
ECgene alternative splicing isoforms for
ADAM17

Expression for ADAM17 Gene

mRNA expression in normal human tissues for ADAM17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ADAM17 Gene

This gene is overexpressed in Bone (19.7), Amniocyte (11.7), Skin (6.7), and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAM17 Gene

SOURCE GeneReport for Unigene cluster for ADAM17 Gene Hs.404914

mRNA Expression by UniProt/SwissProt for ADAM17 Gene

P78536-ADA17_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney
genes like me logo Genes that share expressions with ADAM17: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for ADAM17 Gene

Orthologs for ADAM17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM17 35
  • 88.28 (n)
  • 92.94 (a)
ADAM17 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM17 35
  • 89.59 (n)
  • 94.63 (a)
ADAM17 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam17 35
  • 88.07 (n)
  • 92.11 (a)
Adam17 16
Adam17 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM17 35
  • 99.6 (n)
  • 100 (a)
ADAM17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam17 35
  • 88.03 (n)
  • 92.48 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM17 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves ADAM17 35
  • 74.16 (n)
  • 77.38 (a)
ADAM17 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM17 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam17 35
  • 68.62 (n)
  • 70.57 (a)
zebrafish
(Danio rerio)
Actinopterygii adam17b 35
  • 64.17 (n)
  • 65.37 (a)
wufc20b01 35
adam17a 36
  • 57 (a)
OneToMany
adam17b 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7908 37
  • 41 (a)
Tace 35
  • 51.35 (n)
  • 45.02 (a)
Tace 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002381 35
  • 50.05 (n)
  • 46.06 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-4 37
  • 34 (a)
adm-4 35
  • 47.65 (n)
  • 36.01 (a)
adm-4 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for ADAM17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM17 Gene

ENSEMBL:
Gene Tree for ADAM17 (if available)
TreeFam:
Gene Tree for ADAM17 (if available)

Paralogs for ADAM17 Gene

Paralogs for ADAM17 Gene

Selected SIMAP similar genes for ADAM17 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ADAM17: view

Variants for ADAM17 Gene

Sequence variations from dbSNP and Humsavar for ADAM17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1524668 -- 9,557,243(+) CCATA(A/C)TGTCC upstream-variant-2KB
rs1722693 -- 9,548,154(-) ggttt(G/T)gccac intron-variant
rs1880439 -- 9,541,668(+) ATATC(A/C)TCCAT intron-variant
rs2091211 -- 9,551,618(-) GCCAG(A/G)TGTGG intron-variant
rs2177637 -- 9,535,369(+) TCTAT(C/T)GCTAC intron-variant

Relevant External Links for ADAM17 Gene

HapMap Linkage Disequilibrium report
ADAM17
Human Gene Mutation Database (HGMD)
ADAM17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAM17 Gene

Disorders for ADAM17 Gene

(1) OMIM Diseases for ADAM17 Gene (603639)

UniProtKB/Swiss-Prot

ADA17_HUMAN
  • Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) [MIM:614328]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. {ECO:0000269 PubMed:22010916}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(27) Novoseek inferred disease relationships for ADAM17 Gene

Disease -log(P) Hits PubMed IDs
necrosis 79.5 117
tumors 63.1 122
rheumatoid arthritis 43.1 7
inflammation 34.7 9
alzheimers disease 28.3 5

Relevant External Links for ADAM17

Genetic Association Database (GAD)
ADAM17
Human Genome Epidemiology (HuGE) Navigator
ADAM17
genes like me logo Genes that share disorders with ADAM17: view

No data available for University of Copenhagen DISEASES and Genatlas for ADAM17 Gene

Publications for ADAM17 Gene

  1. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PMID: 9574564) Patel I.R. … Amin A.R. (J. Immunol. 1998) 2 3 4 23
  2. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PMID: 12621058) Fan H. … Derynck R. (J. Biol. Chem. 2003) 3 4 23
  3. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. (PMID: 18600307) Morange P.E. … Tiret L. (J. Mol. Med. 2008) 3 23 48
  4. A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PMID: 9034190) Black R.A. … Cerretti D.P. (Nature 1997) 2 3 4
  5. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PMID: 9034191) Moss M.L. … Becherer J.D. (Nature 1997) 3 4

Products for ADAM17 Gene

Sources for ADAM17 Gene

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