ADAM17 Gene
protein-coding GIFtS: 67
GCID: GC02M009580
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ADAM metallopeptidase domain 17(Previous names: tumor necrosis factor, alpha, converting enzyme )
(Previous symbol: TACE)
| |
Aliases
for ADAM17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 171 2 | | ADAM182 | | TACE1 2 3 5 | | NISBD2 | | CD156B1 2 | | ADAM Metallopeptidase Domain 182 | | Tumor Necrosis Factor, Alpha, Converting Enzyme1 2 | | Disintegrin And Metalloproteinase Domain-Containing Protein 172 | | Snake Venom-Like Protease2 3 | | TNF-Alpha Converting Enzyme2 | | CSVP2 3 | | ADAM 173 | | TNF-Alpha Convertase2 3 | | CD156b Antigen3 | | EC 3.4.24.863 8 | | TNF-Alpha-Converting Enzyme3 | | CSVP2 3 | | |
Export aliases for ADAM17 gene to outside databasesPrevious GC identifers: GC02M009412 GC02M009680 GC02M009651 |
Summaries
for ADAM17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM17:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety ofbiologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, andneurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; bindsmitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release ofseveral other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor,transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Alsoinvolved in the activation of Notch pathway (By similarity)
Gene Wiki entry for ADAM17
|
Genomic Views
for ADAM17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM17 gene promoter:
Bach1 Elk-1 AML1a HOXA3 IRF-1 c-Ets-1 Nkx6-1 ATF En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25ADAM17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M009580: view genomic region
(about GC identifiers)
Start:
|
9,628,615 bp from pter |
End:
|
9,695,921 bp from pter |
Size:
|
67,307 bases |
Orientation:
|
minus strand |
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Proteins
for ADAM17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 17 precursor Size: 824 amino acids; 93021 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with MAD2L1, MAPK14 and MUC1
Subcellular location: Membrane; Single-pass type I membrane protein
6/22 PDB 3D structures from  and Proteopedia  for ADAM17 (see all 22):1BKC (3D)
1ZXC (3D)
2A8H (3D)
2DDF (3D)
2FV5 (3D)
2FV9 (3D)
Secondary accessions: O60226Alternative splicing: 2 isoforms: P78536-1 P78536-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ADAM17: NX_P78536
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 butdecreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomainshedding1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78536
3 DME Specific Peptides for ADAM17 (P78536)
ADAM17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003174.3
ENSEMBL proteins: ENSP00000309968 ENSP00000418728 Reactome Protein details: P78536
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
ADAM17 for ontologies About GeneDecksing
ADAM17 Antibody Products:
Assay Products for ADAM17: |
Protein
Domains /
Families
for ADAM17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P78536ProtoNet protein and cluster: P78536 2 Blocks protein families: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region IPB001762 Disintegrin
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536Domain: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for thethis activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity)Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 peptidase M12B domain |
Function
for ADAM17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release ofseveral other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor,transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Alsoinvolved in the activation of Notch pathway (By similarity)Catalytic activity: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala- -Val-Arg-Ser-Ser-Ser in themembrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored,cell-surface proteins to 'shed' the extracellular domainsInduction: In arthritis-affected cartilage Genatlas biochemistry entry for ADAM17:a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion protein,expressed insomatic tissues,releasing TNFA from its membrane bound precursor,also reported to cleave APP
Enzyme Number (IUBMB): EC 3.4.24.861 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
ADAM17 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADAM17:
Animal Models:
Mouse knock-outs for ADAM17: Adam17tm1.1Bbl Adam17tm1Imx
15/20 MGI mutant phenotypes (inferred from 11 alleles ) (MGI details for Adam17) (see all 20):
ADAM17 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADAM17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | | | 3 | Development_CNTF receptor signaling | | | 4 | Notch Signaling Pathway | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for ADAM17
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADAM17 (see all 6)
2 
Cell Signaling Technology (CST) Pathways for ADAM17
5  GeneGo (Thomson Reuters) Pathways for ADAM17
5/6  BioSystems Pathways for ADAM17 (see all 6)
5/29 
Reactome Pathways for ADAM17 (see all 29)
3 
Kegg Pathways (Kegg details for ADAM17):
ADAM17 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
32/37 Interacting proteins for ADAM17 (P785361, 2, 3 ENSP000003099684) via UniProtKB, MINT, STRING, and/or I2D (see all 37) (see top 5)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| DLG1 | Q129592, 3, ENSP000003457314 | MINT-1901891 MINT-1901801 MINT-1901824 MINT-1901856 MINT-1901710 MINT-1901743 MINT-1901775 I2D:
score=4 STRING: ENSP00000345731 | | PTPN3 | P260452, 3, ENSP000002625394 | MINT-58311 MINT-58317 I2D:
score=3 STRING: ENSP00000262539 | | PDIA3 | P301012, 3 | MINT-4301309 I2D:
score=1 | | MAD2L1 | Q132571, 2, 3, ENSP000002965094 | EBI-78188,EBI-78203 MINT-13999 MINT-13998 I2D:
score=6 STRING: ENSP00000296509 | | MAPK1 | P284823, ENSP000002158324 | I2D:
score=2 STRING: ENSP00000215832 | | APP | P050673, ENSP000002849814 | I2D:
score=1 STRING: ENSP00000284981 | | MAD2L2 | Q9UI953, ENSP000002353104 | I2D:
score=1 STRING: ENSP00000235310 | | SH3D19 | Q5HYK73, ENSP000003029134 | I2D:
score=1 STRING: ENSP00000302913 | | TGFA | P011353, ENSP000002954004 | I2D:
score=1 STRING: ENSP00000295400 | | TIMP3 | P356253, ENSP000002660854 | I2D:
score=3 STRING: ENSP00000266085 | | ERBB4 | Q153033, ENSP000003422354 | I2D:
score=1 STRING: ENSP00000342235 | | FHL2 | Q141923, ENSP000003229094 | I2D:
score=2 STRING: ENSP00000322909 | | NOTCH1 | P465313, ENSP000002775414 | I2D:
score=1 STRING: ENSP00000277541 | | TNF | P013753, ENSP000003986984 | I2D:
score=2 STRING: ENSP00000398698 | | TNFSF11 | O147883, ENSP000002398494 | I2D:
score=1 STRING: ENSP00000239849 | | INSR | P062133 | I2D:
score=1 | | MAPK3 | P273613 | I2D:
score=1 | | ADAM10 | ENSP000002604084 | STRING: ENSP00000260408 | | ADAM12 | ENSP000003576684 | STRING: ENSP00000357668 | | BDNF | ENSP000004143034 | STRING: ENSP00000414303 | | EGF | ENSP000002651714 | STRING: ENSP00000265171 | | EGFR | ENSP000002754934 | STRING: ENSP00000275493 | | ERBB2 | ENSP000002695714 | STRING: ENSP00000269571 | | GHR | ENSP000002308824 | STRING: ENSP00000230882 | | LRIG1 | ENSP000002732614 | STRING: ENSP00000273261 | | NGFR | ENSP000001722294 | STRING: ENSP00000172229 | | PSENEN | ENSP000002222664 | STRING: ENSP00000222266 | | TNFRSF1B | ENSP000003654354 | STRING: ENSP00000365435 | | APH1B | ENSP000002618794 | STRING: ENSP00000261879 | | SORT1 | ENSP000002566374 | STRING: ENSP00000256637 | | ZNF274 | ENSP000004098724 | STRING: ENSP00000409872 | | HBEGF | ENSP000002309904 | STRING: ENSP00000230990 |
About this table
Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table
ADAM17 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAM17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADAM17 for compounds About GeneDecksing
 Browse Tocris compounds for ADAM17
8 DrugBank Compounds for ADAM17 About this table
10/37 Novoseek chemical compound relationships for ADAM17 gene (see all 37) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adamalysin |
84.6 |
3 |
12621058 (1), 10419777 (1) |
| tapi |
78.5 |
4 |
11106509 (1), 11156944 (1) |
| hydroxamate |
76.3 |
10 |
17368021 (1), 15284022 (1), 12723945 (1), 15128827 (1) (see all 7) |
| (4-aminophenyl)mercuric acetate |
70.7 |
2 |
18239612 (1), 15182369 (1) |
| batimastat |
70.4 |
4 |
15319441 (1), 9684866 (1), 10971741 (1), 12226103 (1) |
| marimastat |
58.1 |
4 |
10579851 (3), 12384559 (1) |
| phorbol |
50.3 |
3 |
10799547 (1), 15142990 (1), 19535569 (1) |
| ag 1478 |
46.3 |
1 |
15319441 (1) |
| phorbol-12-myristate |
45.5 |
3 |
17942404 (1) |
| zinc |
40.1 |
24 |
15102849 (4), 15100227 (3), 10521439 (1), 17368021 (1) (see all 12) |
Search CenterWatch for drugs/clinical trials and news about ADAM17 / ADA17
|
Transcripts
for ADAM17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAM17 gene: NM_003183.4 Unigene Cluster for ADAM17: ADAM metallopeptidase domain 17 Hs.404914 [show with all ESTs]Unigene Representative Sequence: NM_0031833 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310823(uc002qzu.3 uc010ewy.3 uc010ewz.3) ENST00000497134(uc010exa.3 uc010exb.1)
ENST00000478059(uc002qzv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAM17 (NM_003183) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17 |
Additional cDNA sequence: AK289829.1 AY422721.1 BC062687.1 BC136783.1 BC146658.1 GQ402545.1 U69611.1 U69612.1 U86755.1 U92649.1 11 DOTS entries: DT.97840889 DT.101978379 DT.75154588 DT.91723298 DT.100737460 DT.91868817 DT.86857558 DT.100671075 DT.121006903 DT.121006944 DT.95089565 24/88 AceView cDNA sequences (see all 88): AI919444 AI741293 AA933982 AI911263 AI095477 AI075423 AI141532 N27387 CB159093 AA827074 BF059089 BM827395 AA910834 AW627690 BM989580 AI797833 AI141804 BU734977 AW057613 AA811251 BE645266 NM_021832 AI910050 AY422721
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADAM17
|
Expression
for ADAM17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ADAM17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM17
SOURCE GeneReport for Unigene cluster: Hs.404914
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle,pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including ADAM17:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17 |
Orthologs
for ADAM17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADAM17 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADAM171 |
ADAM metallopeptidase domain 17 |
74.25(n)
77.51(a) |
|
421931 NM_001008682.1 NP_001008682.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ADAM176 |
-- |
73(a) |
1 ↔ 1 |
1(148417544-148444228) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc20b012 |
wufc20b01 |
75.1(n) |
|
324142 BC057410.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG79083
Tace1 |
proteolysis and peptidolysis
metalloendopeptidase3
CG7908-PA1 |
41(a)3
51.25(n)1
44.87(a)1 |
|
99D13
435581 NM_170455.21 NP_733334.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
adm-41 , 3 |
metalloprotease3
Protein ADM-41 |
34(a)3
48.39(n)1
37.3(a)1 |
|
X(7830565-7833527)3
1810411 NM_076917.21 NP_509318.11 |
ENSEMBL Gene Tree for ADAM17 (if available)
TreeFam Gene Tree for ADAM17 (if available) |
Paralogs
for ADAM17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAM17 gene
- ADAM102
1 SIMAP similar gene for ADAM17 using alignment to 8 protein entries: ADA17_HUMAN (see all proteins):ADAM22
ADAM17 for paralogs About GeneDecksing
|
Genomic Variants
for ADAM17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAM17 (9628615 - 9695921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM17: --
Human Gene Mutation Database (HGMD): ADAM17
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM17 |
|
Disorders
/ Diseases
for ADAM17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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ADAM17 for disorders About GeneDecksing
OMIM gene information: 603639
OMIM disorders: --
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:614328]. NISBD is adisorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skinlesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, andwidespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrentgastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized
20/73  diseases for ADAM17 (see all 73): About MalaCardscleft lip/palate abdominal aortic aneurysm acute myocardial infarction cleft lip
severe acute respiratory syndrome aortic aneurysm inflammatory bowel disease myocardial infarction
congestive heart failure gastrointestinal stromal tumor dilated cardiomyopathy amyotrophic lateral sclerosis
oral squamous cell carcinoma renal osteodystrophy lateral sclerosis squamous cell carcinoma
differentiating neuroblastoma pancreatic ductal adenocarcinoma interstitial lung disease rheumatoid arthritis
10/27 Novoseek disease relationships for ADAM17 gene (see all 27) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
79.5 |
222 |
15206946 (4), 10521439 (2), 15075334 (2), 16737974 (2) (see all 99) |
| tumors |
63.1 |
208 |
15206946 (3), 17822026 (3), 17227756 (3), 10521439 (2) (see all 99) |
| rheumatoid arthritis |
43.1 |
8 |
14579524 (1), 14718605 (1), 12670535 (1), 20303413 (1) (see all 7) |
| inflammation |
34.7 |
14 |
12973924 (1), 19581416 (1), 20331435 (1), 17822026 (1) (see all 9) |
| alzheimers disease |
28.3 |
8 |
19234765 (3), 11032903 (2) |
| arthritis |
24.9 |
5 |
18471442 (1), 12463167 (1), 15859325 (1), 17376651 (1) (see all 5) |
| senile plaques |
23.4 |
1 |
11536196 (1) |
| multiple sclerosis |
15.9 |
5 |
16511637 (2), 19324423 (1), 12474981 (1), 15859325 (1) |
| cancer |
11.6 |
32 |
19843672 (5), 19408347 (2), 15309730 (1), 15197174 (1) (see all 10) |
| osteoarthritis |
5.26 |
6 |
9574564 (1), 14579524 (1), 10419777 (1), 11508576 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADAM17 (16 documents)
Export disorders for ADAM17 gene to outside databases
|
Publications
for ADAM17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM17 gene, integrated from 9 sources (see all 467):
(articles sorted by number of sources associating them with ADAM17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PubMed id 9574564)1, 2, 3, 9 Patel I.R.... Amin A.R. (1998)
- A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PubMed id 9034190)1, 2, 3 Black R.A.... Cerretti D.P. (1997)
- Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PubMed id 12621058)1, 2, 9 Fan H.... Derynck R. (2003)
- Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PubMed id 9034191)1, 2, 9 Moss M.L.... Becherer J.D. (1997)
- Direct activation of TACE-mediated ectodomain sheddin g by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (2010)
- Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. (PubMed id 9520379)1, 2, 9 Maskos K.... Bode W. (1998)
- Inflammatory skin and bowel disease linked to ADAM17 deletion. (PubMed id 22010916)1, 2 Blaydon D.C....Kelsell D.P. (2011)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. (PubMed id 12441351)1, 2 Thathiah A.... Carson D.D. (2003)
- Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. (PubMed id 12058067)1, 2 Diaz-Rodriguez E....Pandiella A. (2002)
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External Searches for ADAM17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
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Genome Databases showing ADAM17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing ADAM17 gene
(According to HUGE)
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| -- |
Specialized Databases showing ADAM17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
About This Section
| Patent Information for ADAM17 gene:
Search GeneIP for patents involving ADAM17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
 |
| | |  | OriGene Antibodies for ADAM17 | | OriGene shRNA RFP for ADAM17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM17 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAM17 | | OriGene 3'-UTR Clone for ADAM17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADAM17 | | OriGene Custom Protein Services for ADAM17 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM17 |
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| | Antibodies & Assays for ADAM17 (TACE) |
| | | | Search Tocris compounds for ADAM17 |
| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM17 |
|  |  |  | | | | ThermoFisher Antibodies for ADAM17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM17 |
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