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ADAM17 Gene

protein-coding GIFtS: 68

GC02M009580

ADAM metallopeptidase domain 17
(Previous names: tumor necrosis factor, alpha, converting enzyme )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TACE)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD156B ^¹, ²
CSVP ^², ³
EC 3.4.24.86 ^³
MGC71942 ^²
TACE ^², ³, ⁵
cSVP ^¹

Descriptions
ADAM 17 ^³
ADAM metallopeptidase domain 17 ^²
CD156b antigen ^³
Snake venom-like protease ^², ³
TNF-alpha convertase ^³
TNF-alpha converting enzyme ^²
TNF-alpha-converting enzyme ^³
a disintegrin and metalloprotease domain 17 ^²
tumor necrosis factor, alpha, converting enzyme ^¹, ²

External Ids
HGNC: 195¹
Entrez Gene: 6868²
UniProtKB: P78536³
Ensembl: ENSG00000151694⁷

Search outside databases for aliases for ADAM17 gene

Previous GC identifers: GC02M009412 GC02M009680 GC02M009651

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM17:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members

of this family are membrane-anchored proteins structurally related to snake venom disintegrins,

and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix

interactions, including fertilization, muscle development, and neurogenesis. The protein encoded

by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest

deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling

pathway. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536

Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible

for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor,

interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin,

growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation

of Notch pathway (By similarity)

Gene Wiki entry for ADAM17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM17 gene

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25

ADAM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M009580: (about GC identifiers)

Start:	9,546,843 bp from pter
End:	9,613,368 bp from pter
Size:	66,526 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 17 precursor

Size: 824 amino acids; 93021 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with MAD2L1 and MUC1

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1BKC (3D)

1ZXC (3D)

2A8H (3D)

2DDF (3D)

2FV5 (3D)

2FV9 (3D)

2I47 (3D)

2OI0 (3D)

3B92 (3D)

3CKI (3D)

3E8R (3D)

3EDZ (3D)

3EWJ (3D)

Secondary accessions: O60226

Alternative splicing: 2 isoforms: P78536-1 P78536-2

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces

phosphorylation of Ser-819 but decreases phosphorylation of Ser-791¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003174.3

ENSEMBL proteins:

ENSP00000309968

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADAM17 Protein
	Sigma-Aldrich CompoZr ZFN for ADAM17
	R&D Systems Recombinant & Natural Proteins for ADAM17 (TACE/ADAM17)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM17)
	Human Recombinant Proteins from Abnova (ADAM17)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005887	integral to plasma membrane	IDA	17786981
GO:0005911	colocalizes with cell-cell junction	IDA	14970227
GO:0005925	colocalizes with focal adhesion	IDA	14970227
GO:0009986	cell surface	IDA	9034190 18383040 18625725

About this table

Antibodies for ADAM17:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM17
	Sigma-Aldrich Antibody Arrays and Antibodies for ADAM17
	R&D Systems Antibodies for ADAM17 (TACE/ADAM17)
	Cell Signaling Technology (CST) Antibodies for ADAM17 (TACE)
	Antibodies from Abcam (ADAM17), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM17)
	Novus Biologicals Antibodies for ADAM17

Assays for ADAM17:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ADAM17 (TACE/ADAM17) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P78536

ProtoNet protein and cluster: P78536

2 Blocks protein families:

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

IPB001762 Disintegrin

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536

Domain: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not

required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR

(By similarity)

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM17)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM17)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003183

Applied Biosystems Silencer® siRNAs for ADAM17

Sigma-Aldrich siRNA and siRNA Panels for ADAM17

Sigma-Aldrich shRNA for ADAM17

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003183
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003183
untagged cDNA clones in CMV expression vector (see all 2): NM_003183

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003183

UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536

Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible

for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor,

interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin,

growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation

of Notch pathway (By similarity)

Catalytic activity: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-

-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha

(TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the

extracellular domains

Induction: In arthritis-affected cartilage

Enzyme Number (IUBMB): EC 3.4.24.86

Genatlas biochemistry entry for ADAM17:

a disintegrin and metalloprotease (active) domain 17,membrane anchored cell surface adhesion

protein,expressed in somatic tissues,releasing TNFA from its membrane bound precursor,also

reported to cleave APP

15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adam17) (see all 16 ):

	digestive/alimentary	embryogenesis	growth/size	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle
normal	pigmentation	respiratory system	skin/coat/nails	touch/vibrissae

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005138	interleukin-6 receptor binding	IPI	16034137
GO:0005178	integrin binding	IPI	14970227
GO:0005515	protein binding	IPI	10527948
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ADAM17 (Your Favorite Gene powered by Ingenuity)

Notch Signaling
Neuregulin Signaling
Axonal Guidance Signaling

GeneDecks ADAM17 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADAM17

5/61 Interacting proteins for ADAM17 (P78536^{1, 2} ENSP00000309968³) via UniProtKB, MINT, and/or STRING (see all 61 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG1	Q12959², ENSP00000345731³	MINT-1901891 MINT-1901801 MINT-1901824 MINT-1901856 MINT-1901710 MINT-1901743 MINT-1901775 STRING (score=.754)
MAD2L1	Q13257¹^,²	EBI-78188, EBI-78203 MINT-13999 MINT-13998 EBI-78188, EBI-78203 MINT-13999 MINT-13998
MAD2L1	Q13257¹^,²	EBI-78188, EBI-78203 MINT-13999 MINT-13998 EBI-78188, EBI-78203 MINT-13999 MINT-13998
PTPN3	P26045²	MINT-58311 MINT-58317
PDIA3	P30101²	MINT-4301309

About this table

5/28 Gene Ontology (GO) biological process terms (links to tree view) (see all 28 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	18276953
GO:0001934	positive regulation of protein amino acid phosphorylation	IMP	18625725
GO:0002446	neutrophil mediated immunity	IC	16034137
GO:0002467	germinal center formation	ISS	10433800
GO:0006508	proteolysis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM17

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM17
10/22 Novoseek chemical compound relationships for ADAM17 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adamalysin	86.16	3	12621058 (1), 10419777 (1)
tapi	79.30	4	11106509 (1), 11156944 (1)
hydroxamate	77.58	10	17368021 (1), 15284022 (1), 12723945 (1), 15128827 (1) (see all 7)
(4-aminophenyl)mercuric acetate	71.69	2	18239612 (1), 15182369 (1)
phorbol	48.29	2	10799547 (1), 15142990 (1)
phorbol-12-myristate	47.06	3	17942404 (1)
zinc	39.92	24	15102849 (4), 15100227 (3), 10521439 (1), 17368021 (1) (see all 12)
1,10-phenanthroline	20.57	3	14659806 (1), 16002728 (1), 12226103 (1)
nadph	13.37	2	15640347 (1), 17220369 (1)
ionomycin	12.36	2	15556048 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM17)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM17)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003183

Sigma-Aldrich siRNA and siRNA Panels for ADAM17

Sigma-Aldrich shRNA for ADAM17

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003183

REFSEQ mRNAs for ADAM17 gene:

NM_003183.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003183

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003183
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003183
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003183

Additional cDNA sequence:

AK289829.1 AY422721.1 BC062687.1 BC136783.1 BC146658.1 U69611.1 U69612.1 U86755.1

U92649.1

12 DOTS entries:

DT.97840889 DT.101978379 DT.75154588 DT.91723298 DT.100737460 DT.100671075 DT.86857558 DT.91868817

DT.95089565 DT.121006903 DT.121006944 DT.75199142

24/88 AceView cDNA sequences (see all 88 ):

BM989580 AA910834 AI141804 BM827395 AA827074 AW627690 AI797833 BF059089

CB159093 BU734977 AI741293 AI911263 AW057613 AI919444 AA933982 N27387

AI075423 AI095477 AI141532 AI676046 BU198020 CB068513 AA434196 AA884442

highest scoring ESTs for ADAM17:

U69611 AI910050 BQ429472 U69612 U86755 U92649 AU127930 BF915290 BM827395 BP872759

Unigene Cluster for ADAM17:

ADAM metallopeptidase domain 17

Hs.404914 [show with all ESTs]

Unigene Representative Sequence: NM_003183

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM17

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19
SP1:													-
SP2:																													-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ADAM17

1 Ensembl transcript including schematic representation:

ENST00000310823

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADAM17 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM17

¹ / ² / ³

6 probe-sets matching ADAM17 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1227_g_at²^{, 3}	U95-A	1	1.00	1.00	0.48	0.29	U69611	1.00	0.90	0.95	1
1226_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U69611	1.00	0.90	0.95	1
205746_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U86755	0.80	0.88	0.84	1
205745_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_003183	0.60	1.00	0.82	1
205746_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205745_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.404914
Expression variation in blood from EXPOLDB for ADAM17
UniProtKB/Swiss-Prot: ADA17_HUMAN, P78536
Tissue specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta,
skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in
fetal brain, lung, liver and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM17 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADAM17¹	--	ADAM metallopeptidase domain 17	99.6(n) 100(a)	459018 XM_515293.2 XP_515293.2
cow (Bos taurus)	ADAM17¹	--	ADAM metallopeptidase domain 17	88.28(n) 92.94(a)	517541 XM_595713.3 XP_595713.2
rat (Rattus norvegicus)	Adam17¹	--	ADAM metallopeptidase domain 17	88.03(n) 92.48(a)	57027 NM_020306.1 NP_064702.1
mouse (Mus musculus)	Adam17^{1, 5}	12 (3.00 cM)⁵	a disintegrin and metallopeptidase domain 17^{1, 5}	88.07(n)¹ 92.11(a)¹	11491¹ NM_009615.5¹ NP_033745.4¹ AB021709⁵ AF056345⁵ (see all 45)
chicken (Gallus gallus)	ADAM17¹	--	ADAM metallopeptidase domain 17 (tumor necrosis factor, more	74.25(n) 77.51(a)	421931 NM_001008682.1 NP_001008682.1

About this table Species with no ortholog for ADAM17

ENSEMBL Gene Tree for ADAM17

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM17 gene

ADAM10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/344 NCBI SNPs in ADAM17 are shown (see all 344 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 112)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6705408^1,2	A,C,F,H	9547682(+)	`AAATAC/TAAGCT`	1	--	ut3¹		7	NA EU EA WA	560
	rs1130094^1,2	C,F,H	9547467(-)	`TATGAA/GTATTT`	1	--	ut3¹ ese³		13	NS MN NA EU EA WA	816
--	rs13008101^1,2	C,F	9546818(+)	`AAATAT/GTCTAG`	1	--	ng5¹		3	NA	142
	rs34431503^1,2	C,F	9585501(-)	`AAGACA/GAAAGA`	1	K/E	mis¹		5	NA EU EA WA	498
--	rs2230818^1,2	F	9585381(-)	`TAGACA/GGAGAA`	1	R/G	mis¹ ese³		13	MN NA EU EA WA	1104
	rs1048610^1,2	A,C,F,H	9552307(-)	`CTTTCT/CGGCCG`	1	S/S	syn¹ ese³		14	MN EA NA EU WA	2514
	rs2276338^1,2	A,C,F,H,O	9563240(+)	`GCCCAC/TTTAAG`	1	--	int¹		14	EA NA EU WA	2476
	rs883399^1,2	A,C,F,H,O	9551551(+)	`TCCGCA/GTAATG`	1	--	int¹		20	EA NA EU WA NS	2728
	rs12467921^1,2	A,C,F,H	9561139(+)	`TGGGCA/Ggccag`	1	--	int¹		4	EU EA WA	414
	rs6745500^1,2	A,C,F,H	9557977(+)	`tgagtT/Cgtggg`	1	--	int¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for ADAM17 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603639

10/27 Novoseek disease relationships for ADAM17 gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	79.06	194	15206946 (4), 10521439 (2), 15075334 (2), 16737974 (2) (see all 99)
tumors	62.47	176	15206946 (3), 17822026 (3), 17227756 (3), 10521439 (2) (see all 99)
rheumatoid arthritis	39.75	6	14579524 (1), 14718605 (1), 12670535 (1), 11508576 (1) (see all 5)
inflammation	33.83	11	12973924 (1), 17822026 (1), 11934805 (1), 19253070 (1) (see all 7)
alzheimers disease	29.72	8	19234765 (3), 11032903 (2)
arthritis	27.81	5	18471442 (1), 12463167 (1), 15859325 (1), 17376651 (1) (see all 5)
senile plaques	26.07	1	11536196 (1)
multiple sclerosis	19.10	5	16511637 (2), 19324423 (1), 12474981 (1), 15859325 (1)
inflammatory bowel diseases	8.49	2	10415810 (1), 14678276 (1)
cancer	4.63	10	19408347 (2), 15309730 (1), 15197174 (1), 17355265 (1) (see all 8)

About this table

Human Genome Epidemiology Navigator: ADAM17 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/339 PubMed articles for ADAM17 gene (see all 339 ):

TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. (PubMed id 9574564)^{1, 2, 3, 4} Patel I.R....Amin A.R. (1998)
A metalloproteinase disintegrin that releases tumour-necrosis factor- alpha from cells. (PubMed id 9034190)^{2, 3, 4} Black R.A.... Cerretti D.P. (1997)
Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. (PubMed id 12621058)^{1, 3, 4} Fan H.... Derynck R. (2003)
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. (PubMed id 9034191)^{1, 3, 4} Moss M.L.... Becherer J.D. (1997)
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. (PubMed id 9520379)^{1, 3, 4} Maskos K.... Bode W. (1998)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. (PubMed id 12441351)^{3, 4} Thathiah A....Carson D.D. (2003)
Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. (PubMed id 12058067)^{3, 4} Diaz-Rodriguez E....Pandiella A. (2002)
Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. (PubMed id 18600307)^{1, 3} Morange P.E....Tiret L. (2008)
ADAM17 mRNA expression and pathological features of hepatocellular carcinoma. (PubMed id 15309730)^{1, 3} Ding X....Lu W.Q. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6868	HGNC: 195	AceView: ADAM17	Ensembl:ENSG00000151694	euGenes: HUgn6868
ECgene: ADAM17	H-InvDB: ADAM17

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADAM17	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Tumor_Necrosis_Factor_Alpha_Converting_Enzyme

Licensable Technologies for ADAM17
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADAM17:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM17-related products

	Millipore Custom Antibody & Bulk Services
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	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies & Assays for ADAM17 (TACE)

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Search OriGene for ADAM17

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Antibodies for ADAM17

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ADAM17 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ADAM17

Summaries
for ADAM17

Genomic Location
for ADAM17

Proteins
for ADAM17

Protein Domains/
Families
for ADAM17

Gene Function
for ADAM17

Pathways & Interactions
for ADAM17

Drugs & Compounds
for ADAM17

Transcripts
for ADAM17

Expression
for ADAM17

Orthologs
for ADAM17

Paralogs
for ADAM17

SNPs/Variants
for ADAM17

Disorders & Mutations
for ADAM17

Medical News
for ADAM17

Publications
for ADAM17

Search for ADAM17

Genome Databases showing ADAM17

Other Databases showing ADAM17

Specialized Databases showing ADAM17

Licensable Technologies
for ADAM17

Services
for ADAM17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM17 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ADAM17

Summariesfor ADAM17

Genomic Locationfor ADAM17

Proteinsfor ADAM17

Protein Domains/Familiesfor ADAM17

Gene Functionfor ADAM17

Pathways & Interactionsfor ADAM17

Drugs & Compoundsfor ADAM17

Transcriptsfor ADAM17

Expression for ADAM17

Orthologsfor ADAM17

Paralogsfor ADAM17

SNPs/Variantsfor ADAM17

Disorders & Mutationsfor ADAM17

Medical Newsfor ADAM17

Publicationsfor ADAM17

Search for ADAM17

Genome Databases showing ADAM17

Other Databases showing ADAM17

Specialized Databases showing ADAM17

Licensable Technologiesfor ADAM17

Servicesfor ADAM17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM17

Summaries
for ADAM17

Genomic Location
for ADAM17

Proteins
for ADAM17

Protein Domains/
Families
for ADAM17

Gene Function
for ADAM17

Pathways & Interactions
for ADAM17

Drugs & Compounds
for ADAM17

Transcripts
for ADAM17

Expression
for ADAM17

Orthologs
for ADAM17

Paralogs
for ADAM17

SNPs/Variants
for ADAM17

Disorders & Mutations
for ADAM17

Medical News
for ADAM17

Publications
for ADAM17

Licensable Technologies
for ADAM17

Services
for ADAM17