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ADAM15 Gene

protein-coding GIFtS: 65

GC01P153290

ADAM metallopeptidase domain 15
(Previous name: a disintegrin and metalloproteinase domain 15 (metargidin) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.- ^³
MDC-15 ^³
MDC15 ^¹, ², ³, ⁵
Metargidin ^³
OTTHUMP00000015780 ^²
metargidin ^²

Descriptions
ADAM 15 ^³
ADAM metallopeptidase domain 15 ^²
Metalloprotease RGD disintegrin protein ^², ³
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 ^², ³
a disintegrin and metalloproteinase domain 15 ^²
a disintegrin and metalloproteinase domain 15 (metargidin) ^¹, ²

External Ids
HGNC: 193¹
Entrez Gene: 8751²
UniProtKB: Q13444³
Ensembl: ENSG00000143537⁷

Search outside databases for aliases for ADAM15 gene

Previous GC identifers: GC01M148227 GC01P150754 GC01P151799 GC01P152240 GC01P151836

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM15:

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase)

protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in

cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This

protein contains multiple functional domains including a zinc-binding metalloprotease domain, a

disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this

protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src

family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this

protein may function in cell-cell adhesion as well as in cellular signaling. Multiple

alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided

by RefSeq]

UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444

Function: May be involved in cell-surface proteolysis, cell adhesion or intracellular protein

maturation

Gene Wiki entry for ADAM15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM15 gene

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3

ADAM15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P153290: (about GC identifiers)

Start:	153,290,386 bp from pter
End:	153,301,876 bp from pter
Size:	11,491 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 15 precursor

Size: 814 amino acids; 87717 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Interacts with ITAGV-ITGB3 (vitronectin receptor), PACSIN3 and SNX9. PACSIN3 and SNX9

preferentially bind the precursor but not the processed form of ADAM15, suggesting that the

interaction occurs in a secretory pathway compartment prior to the medial Golgi (By similarity).

Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q13493 Q53XQ0 Q5SR69 Q96C78

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

Phosphorylation increases association with PTKs¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_003806.3 NP_997074.1 NP_997077.1 NP_997078.1 NP_997079.1 NP_997080.1

ENSEMBL proteins:

ENSP00000349436 ENSP00000348227 ENSP00000352226 ENSP00000271836 ENSP00000357395 ENSP00000357398

ENSP00000357397 ENSP00000353892

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAM15
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM15)
	Human Recombinant Proteins from Abnova (ADAM15)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ADAM15:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM15
	Sigma-Aldrich Antibodies for ADAM15
	R&D Systems Antibodies for ADAM15
	Antibodies from Abcam (ADAM15), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM15)
	Novus Biologicals Antibody for ADAM15

Assays for ADAM15:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13444

ProtoNet protein and cluster: Q13444

4 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006210 Type I EGF

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444

Domain: The cytoplasmic domain interacts with endophilin I and sorting nexin 9 (By similarity)

Domain: Desintegrin domain binds to integrin alphaV-beta3

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM15)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_003815

Applied Biosystems Silencer® siRNAs for ADAM15

Sigma-Aldrich siRNA and siRNA Panels for ADAM15

Sigma-Aldrich shRNA Panels and shRNA for ADAM15

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADAM15
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_003815
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_003815
untagged cDNA clones in CMV expression vector (see all 6): NM_003815

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207197

UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444

Function: May be involved in cell-surface proteolysis, cell adhesion or intracellular protein

maturation

Enzyme Number (IUBMB): EC 3.4.24.-

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adam15):

lethality-prenatal/perinatal

tumorigenesis

vision/eye

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	10531379
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM15 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks ADAM15 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADAM15

5/28 Interacting proteins for ADAM15 (ENSP00000349436³ Q13444^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3GL2	Q99962¹	STRING (score=.962) EBI-77818, EBI-77938
GRB2	P62993²	STRING (score=.91) MINT-2792561 MINT-2792581
FYN	P06241²	STRING (score=.853) MINT-2792412
HCK	P08631²	STRING (score=.909) MINT-2792352
SNX9	Q9Y5X1²	STRING (score=.983) MINT-2792432

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007160	cell-matrix adhesion	TAS	9516430

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM15

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM15
2 Novoseek chemical compound relationships for ADAM15 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tripeptide	49.89	6	9516430 (1), 9914169 (1), 15618016 (1)
fibrinogen	29.23	1	16268472 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM15)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_003815

Sigma-Aldrich siRNA and siRNA Panels for ADAM15

Sigma-Aldrich shRNA Panels and shRNA for ADAM15

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003815 NM_207191 NM_207194 NM_207195 NM_207196 NM_207197

REFSEQ mRNAs for ADAM15 gene (6 alternative transcripts):

NM_003815.3 NM_207191.1 NM_207194.1 NM_207195.1 NM_207196.1 NM_207197.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003815 NM_207191 NM_207194 NM_207195 NM_207196 NM_207197

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_003815
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_003815
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_003815

Additional cDNA sequence:

AK000667.1 AK075498.1 AK295614.1 AK296925.1 AK297468.1 AK308172.1 AY518542.1 AY560593.1

AY560594.1 AY560595.1 AY560596.1 AY560597.1 AY560598.1 AY560599.1 AY560600.1 AY560601.1

AY576417.1 BC014566.2 BT009764.1 CR603003.1 CR614548.1 U41767.1 U46005.1

24/30 DOTS entries (see all 30 ):

DT.92048682 DT.102843113 DT.95179450 DT.102843115 DT.100766007 DT.99979216 DT.101982838 DT.75193611

DT.305855 DT.100820027 DT.102843114 DT.40236644 DT.100696384 DT.92443727 DT.95262856 DT.100697818

DT.121413863 DT.92443731 DT.92443732 DT.95217362 DT.100676267 DT.100820017 DT.100820034 DT.121413753

24/380 AceView cDNA sequences (see all 380 ):

BC014566 BM824762 BG488647 AY560593 AY560597 BG254075 BU543665 BM822157

BU625765 BQ775998 BM683404 AY518542 BC064844 AI660841 BU169027 BE877474

AA295191 BM818678 AY560598 CA748879 CK903493 AI380702 AY560601 BE784428

highest scoring ESTs for ADAM15:

U41767 AA007366 AA069039 AA155587 AA292676 AA527517 AA565906 AA577569 AA643143 AA678849

Unigene Cluster for ADAM15:

ADAM metallopeptidase domain 15

Hs.312098 [show with all ESTs]

Unigene Representative Sequence: AY560601

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM15 (see all 21 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^
SP1:															-		-												-
SP2:															-		-												-
SP3:															-		-												-
SP4:															-		-												-
SP5:															-		-												-

ExUns:	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25
SP1:																											-				-
SP2:																											-
SP3:																											-				-
SP4:																											-
SP5:																											-		-		-

About this scheme

ECgene alternative splicing isoforms for ADAM15

8 Ensembl transcripts including schematic representations:

ENST00000356955 ENST00000355956 ENST00000359280 ENST00000271836 ENST00000368410 ENST00000368413

ENST00000368412 ENST00000360674

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADAM15 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM15

¹ / ² / ³

4 probe-sets matching ADAM15 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38282_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U41767	1.00	1.00	1.00	1
217007_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK000667	0.60	1.00	0.82	1
217007_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555896_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGAAGGCG

SOURCE GeneReport for Unigene cluster: Hs.312098
Expression variation in blood from EXPOLDB for ADAM15
UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444
Tissue specificity: Ubiquitously expressed. Overexpressed in atherosclerotic lesions.
Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM15 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAM15¹	--	ADAM metallopeptidase domain 15	83.72(n) 82.02(a)	490434 XM_847050.1 XP_852143.1
chimpanzee (Pan troglodytes)	ADAM15¹	--	ADAM metallopeptidase domain 15	99.22(n) 98.77(a)	457354 XM_513846.2 XP_513846.2
cow (Bos taurus)	ADAM15¹	--	ADAM metallopeptidase domain 15	85(n) 83.06(a)	784605 XM_001252360.1 XP_001252361.1
rat (Rattus norvegicus)	Adam15¹	--	a disintegrin and metallopeptidase domain 15 (metargidin)	83.29(n) 81.82(a)	57025 NM_020308.1 NP_064704.1
mouse (Mus musculus)	Adam15^{1, 5}	3 (44.40 cM)⁵	a disintegrin and metallopeptidase domain 15 (metargidin)^{1, 5}	82.75(n)¹ 80.28(a)¹	11490¹ NM_001037722.2¹ NP_001032811.2¹ AA980416⁵ AB022089⁵ (see all 35)

About this table Species with no ortholog for ADAM15

ENSEMBL Gene Tree for ADAM15

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM15 gene

ADAM19² ADAM12² ADAM33²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in ADAM15 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6427128^1,2	C,F,H	153293566(+)	`TCAGAC/AGCCAC`	6	T/K	mis¹ ese³		8	EU EA WA	838
	rs2306122^1,2	C,H	153295316(+)	`GCTGCC/ATCGAT`	6	H/P	mis¹ ese³		4	EU EA WA	420
	rs11264303^1,2	A,C,F,H	153297181(+)	`CAGACA/CGCTAA`	6	T/T	syn¹ ese³		9	MN EU EA WA	1024
	rs11589479^1,2	C,F,H	153299932(+)	`ACTAAG/AGTGAG`	6	K/K	syn¹ int¹		8	EU EA WA	836
	rs11548311^1,2	C,F	153293495(+)	`ATTTCG/TCGAAT`	6	S/S	syn¹		3	MN NA	366
	rs11264302^1,2	A,C,F,H	153295146(+)	`CCATGA/GCAACC`	6	--	int¹		8	EU EA WA	830
	rs3765087^1,2	A,C,F,H	153295877(+)	`acccaA/Cgtttc`	6	--	int¹		7	EU EA WA NA	560
	rs12023499^1,2	A,C,F,H	153298000(+)	`cttccT/Cagttg`	6	--	int¹		8	EU EA WA	836
	rs11264305^1,2	A,C,F,H	153300196(+)	`GGTGGG/ATCTAT`	6	--	int¹		8	EU EA WA	838
	rs2306125^1,2	A,C,F,H	153291985(+)	`CTCACC/TGTAGT`	6	--	int¹		5	EA EU WA	1922

About this table

HapMap Linkage Disequilibrium images for ADAM15 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605548

10/11 Novoseek disease relationships for ADAM15 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	21.36	7	18281484 (2), 19229865 (1), 15756594 (1), 18518760 (1) (see all 6)
osteoarthritis	19.64	5	11592366 (1), 15818704 (1)
cancer	17.95	9	17937806 (2), 19207106 (2), 15618016 (1), 15384173 (1) (see all 5)
atherosclerosis	15.99	6	9039960 (2), 17905725 (1), 19253070 (1)
tumors	15.31	20	15756594 (4), 19229865 (3), 16756724 (2), 18281484 (2) (see all 8)
breast cancer	9.97	9	18434311 (2), 16756724 (2), 15384173 (2), 18296648 (1)
rheumatoid arthritis	9.08	3	11592366 (1), 17905725 (1)
carcinoma	4.65	3	18296648 (2), 8617717 (1)
necrosis	0.00	1	16277668 (1)
adenocarcinoma	0.00	3	16756724 (2), 15756594 (1)

About this table

Human Genome Epidemiology Navigator: ADAM15 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/71 PubMed articles for ADAM15 gene (see all 71 ):

Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. (PubMed id 9516430)^{1, 2, 3, 4} Zhang X.P.... Takada Y. (1998)
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PubMed id 11741929)^{1, 3, 4} Poghosyan Z....Edwards D.R. (2002)
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. (PubMed id 8617717)^{1, 3, 4} Kraetzschmar J.... Blobel C.P. (1996)
Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. (PubMed id 9039960)^{1, 3, 4} Herren B.... Ross R. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)^{3, 4} Abram C.L....Courtneidge S.A. (2003)
Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. (PubMed id 9016778)^{3, 4} McKie N.... Croucher P.I. (1997)
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. (PubMed id 9914169)^{1, 3} Nath D....Murphy G. (1999)
ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. (PubMed id 18387333)^{1, 3} Chen Q....Ding J. (2008)
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. (PubMed id 19207106)^{1, 3} Maretzky T....Blobel C.P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8751	HGNC: 193	AceView: ADAM15andFLJ32785	Ensembl:ENSG00000143537	euGenes: HUgn8751
ECgene: ADAM15	H-InvDB: ADAM15

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ADAM15
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADAM15:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM15-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM15		Antibodies for ADAM15
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM15		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADAM15)
	Antibodies (ADAM15)
	Chimera RNAi (ADAM15)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ADAM15)
	Antibodies (ADAM15)

Search OriGene for ADAM15

Search Tocris compounds for ADAM15

	Drugs for ADAM15
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADAM15

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADAM15 Gene at Home site.
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ADAM15 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ADAM15

Summaries
for ADAM15

Genomic Location
for ADAM15

Proteins
for ADAM15

Protein Domains/
Families
for ADAM15

Gene Function
for ADAM15

Pathways & Interactions
for ADAM15

Drugs & Compounds
for ADAM15

Transcripts
for ADAM15

Expression
for ADAM15

Orthologs
for ADAM15

Paralogs
for ADAM15

SNPs/Variants
for ADAM15

Disorders & Mutations
for ADAM15

Medical News
for ADAM15

Publications
for ADAM15

Search for ADAM15

Genome Databases showing ADAM15

Other Databases showing ADAM15

Specialized Databases showing ADAM15

Licensable Technologies
for ADAM15

Services
for ADAM15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM15 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ADAM15

Summariesfor ADAM15

Genomic Locationfor ADAM15

Proteinsfor ADAM15

Protein Domains/Familiesfor ADAM15

Gene Functionfor ADAM15

Pathways & Interactionsfor ADAM15

Drugs & Compoundsfor ADAM15

Transcriptsfor ADAM15

Expression for ADAM15

Orthologsfor ADAM15

Paralogsfor ADAM15

SNPs/Variantsfor ADAM15

Disorders & Mutationsfor ADAM15

Medical Newsfor ADAM15

Publicationsfor ADAM15

Search for ADAM15

Genome Databases showing ADAM15

Other Databases showing ADAM15

Specialized Databases showing ADAM15

Licensable Technologiesfor ADAM15

Servicesfor ADAM15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM15

Summaries
for ADAM15

Genomic Location
for ADAM15

Proteins
for ADAM15

Protein Domains/
Families
for ADAM15

Gene Function
for ADAM15

Pathways & Interactions
for ADAM15

Drugs & Compounds
for ADAM15

Transcripts
for ADAM15

Expression
for ADAM15

Orthologs
for ADAM15

Paralogs
for ADAM15

SNPs/Variants
for ADAM15

Disorders & Mutations
for ADAM15

Medical News
for ADAM15

Publications
for ADAM15

Licensable Technologies
for ADAM15

Services
for ADAM15