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ADAM15 Gene

protein-coding   GIFtS: 68
GCID: GC01P155023

ADAM Metallopeptidase Domain 15

(Previous name: a disintegrin and metalloproteinase domain 15 (metargidin))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 151 2     metargidin1
MDC152 3 5     Disintegrin And Metalloproteinase Domain-Containing Protein 152
A Disintegrin And Metalloproteinase Domain 15 (Metargidin)1 2     EC 3.4.24.-3
Metalloprotease RGD Disintegrin Protein2 3     Metargidin3
Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 152 3     ADAM 153
MDC-152 3     EC 3.4.248

External Ids:    HGNC: 1931   Entrez Gene: 87512   Ensembl: ENSG000001435377   OMIM: 6055485   UniProtKB: Q134443   

Export aliases for ADAM15 gene to outside databases

Previous GC identifers: GC01M148227 GC01P150754 GC01P151799 GC01P152240 GC01P151836 GC01P153290 GC01P126385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM15 Gene:
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family.
ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic
ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains
including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through
its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also
interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this
protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced
transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM15 Gene:
ADAM15 (ADAM metallopeptidase domain 15) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity and SH3 domain binding. An important paralog of this gene is ADAM7.

UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444
Function: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound
healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell
aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells.
Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell
surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a
role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage
remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May
play a role in sperm-egg binding through its disintegrin domain

Gene Wiki entry for ADAM15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM15 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM15 promoter sequence
   Search Chromatin IP Primers for ADAM15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21.3

ADAM15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155023:  view genomic region     (about GC identifiers)

Start:
155,023,042 bp from pter      End:
155,035,252 bp from pter
Size:
12,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 15 precursor  
Size: 863 amino acids; 92959 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction
occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory
pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1 (By similarity). Interacts specifically
with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts
with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC
Secondary accessions: B3KQU5 B4DLB5 E9PN65 Q13493 Q53XQ0 Q5SR68 Q5SR69 Q6R267 Q71S61 Q71S62
Q71S63 Q71S64 Q71S65 Q71S66 Q71S67 Q71S68 Q71S69 Q96C78
Alternative splicing: 12 isoforms:  Q13444-1   Q13444-2   Q13444-3   Q13444-4   Q13444-5   Q13444-6   Q13444-7   Q13444-8   
Q13444-9   Q13444-10   Q13444-11   Q13444-12   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAM15: NX_Q13444

Explore proteomics data for ADAM15 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Phosphorylation increases association with PTKs1
  • Glycosylation2 at Asn237, Asn389, Asn392, Asn606, Asn611
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ADAM15 (Q13444)
     KCHGHGVC  GHSLGLDH  EGWAPPDC  SGGVNMDHS 


    See ADAM15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001248393.1  NP_001248394.1  NP_001248395.1  NP_003806.3  NP_997074.1  NP_997077.1  NP_997078.1  NP_997079.1  
    NP_997080.1  

    ENSEMBL proteins: 
     ENSP00000434227   ENSP00000432347   ENSP00000349436   ENSP00000403843   ENSP00000352226  
     ENSP00000353892   ENSP00000357397   ENSP00000348227   ENSP00000271836   ENSP00000357398  
     ENSP00000432927   ENSP00000476000   ENSP00000357395  
    Reactome Protein details: Q13444

    ADAM15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADAM15

     
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    ADAM15 Antibody Products:

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    ADAM15 Assay Products:

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    Cloud-Clone Corp. ELISAs for ADAM15
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    Search eBioscience for ELISAs for ADAM15 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM15
    ADAM

    Selected InterPro protein domains (see all 7):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q13444

    ProtoNet protein and cluster: Q13444

    4 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444
    Domain: The cytoplasmic domain is required for SH3GL2- and SNX9-binding
    Domain: Disintegrin domain binds to integrin alphaV-beta3
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Find genes that share domains with ADAM15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA15_HUMAN, Q13444
    Function: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound
    healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell
    aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells.
    Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell
    surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a
    role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage
    remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May
    play a role in sperm-egg binding through its disintegrin domain
    Enzyme regulation: Inhibited by hydroxamate-type metalloproteinase inhibitors such as marimastat. Inhibited by
    metalloproteinase inhibitor 2 (TIMP-2) and TIMP-3 at nanomolar concentrations. Not significantly inhibited by
    TIMP-1 at concentrations of up to 100 nM. Not activated by PMA or ionomycin

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI10531379
    GO:0008237metallopeptidase activity IDA12777399
    GO:0008270zinc ion binding IEA--
    GO:0017124SH3 domain binding IPI10531379
         
    Find genes that share ontologies with ADAM15           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAM15:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam15):
     cardiovascular system  mortality/aging  tumorigenesis  vision/eye 

    Find genes that share phenotypes with ADAM15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADAM15: Adam15tm1Dgen Adam15tm1Bbl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM15

    miRNA
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    miRTarBase miRNAs that target ADAM15:
    hsa-mir-124-3p (MIRT022149), hsa-mir-18a-5p (MIRT050739)

    Block miRNA regulation of human, mouse, rat ADAM15 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ADAM15:
    hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidADAM15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAM15

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): ADAM15 (NM_207195)
    Sino Biological Human cDNA Clone for ADAM15
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA15_HUMAN, Q13444: Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction.
    Cell projection, cilium, flagellum (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By
    similarity). Note=The majority of the protein is localized in a perinuclear compartment which may correspond to
    the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface,
    whereas the majority of the protein in the cell is processed (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0005912adherens junction IEA--
    GO:0012505endomembrane system ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ADAM15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM15 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    3Notch Signaling Pathway (sino)
    Notch Signaling Pathway


    Find genes that share SuperPaths with ADAM15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ADAM15
        Notch Signaling Pathway

    1 Reactome Pathway for ADAM15
        Degradation of the extracellular matrix


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM15
    Interactions:

        GeneGlobe Interaction Network for ADAM15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADAM15 (Q134441, 2, 3 ENSP000003494364) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062391, 2, 3, ENSP000003378254EBI-77818,EBI-1348 MINT-7218127 MINT-7218109 MINT-7218034 I2D: score=6 STRING: ENSP00000337825
    HCKP086311, 2, 3, ENSP000003650124EBI-77818,EBI-346340 MINT-2792352 MINT-7218089 MINT-7218157 I2D: score=4 STRING: ENSP00000365012
    FYNP062411, 2, 3, ENSP000003576564EBI-77818,EBI-515315 MINT-7218171 MINT-2792412 I2D: score=4 STRING: ENSP00000357656
    SH3PXD2AQ5TCZ11, 2, 3, ENSP000003482154EBI-77818,EBI-2483234 MINT-2792498 MINT-2792970 I2D: score=4 STRING: ENSP00000348215
    NPHP1O152591, 2, 3, ENSP000003131694EBI-77818,EBI-953828 MINT-2792990 MINT-2792478 I2D: score=2 STRING: ENSP00000313169
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006508proteolysis ----
    GO:0007160cell-matrix adhesion TAS9516430
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with ADAM15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM15 (ADA15)

    3 Novoseek inferred chemical compound relationships for ADAM15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 46.9 6 9516430 (1), 9914169 (1), 15618016 (1)
    fibrinogen 25.6 1 16268472 (1)
    paraffin 12.3 1 15756594 (1)



    Find genes that share compounds with ADAM15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAM15 gene (9 alternative transcripts): 
    NM_001261464.1  NM_001261465.1  NM_001261466.1  NM_003815.4  NM_207191.2  NM_207194.2  NM_207195.2  NM_207196.2  
    NM_207197.2  

    Unigene Cluster for ADAM15:

    ADAM metallopeptidase domain 15
    Hs.312098  [show with all ESTs]
    Unigene Representative Sequence: NR_048578
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000473905 ENST00000533732 ENST00000480331 ENST00000527418(uc001fgq.1 uc001fgt.1 uc001fgs.1 uc010pev.1 uc001fgr.1 uc001fgu.1 uc001fgv.1 uc001fgw.1 uc001fgx.1)
    ENST00000529473(uc001fha.1) ENST00000526491(uc001fgz.1 uc001fgy.1)
    ENST00000356955 ENST00000449910 ENST00000359280 ENST00000360674(uc009wpc.1)
    ENST00000368412 ENST00000355956 ENST00000531703 ENST00000477533 ENST00000271836
    ENST00000461564(uc010peu.1) ENST00000485346 ENST00000368413
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    7 qRT-PCR Assays for microRNAs that regulate ADAM15:
    hsa-miR-137 hsa-miR-92a hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidADAM15 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 6): ADAM15 (NM_207195)
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      QuantiFast Probe-based Assays in human, mouse, rat ADAM15

    Additional mRNA sequence: 

    AK000667.1 AK075498.1 AK295614.1 AK296925.1 AK297468.1 AK308172.1 AY518542.1 AY560593.1 
    AY560594.1 AY560595.1 AY560596.1 AY560597.1 AY560598.1 AY560599.1 AY560600.1 AY560601.1 
    AY576417.1 BC014566.2 BT009764.1 NR_048577.1 NR_048578.1 NR_048579.1 U41767.1 U46005.1 

    Selected DOTS entries (see all 29):

    DT.92048682  DT.102843113  DT.95179450  DT.102843115  DT.100766007  DT.99979216  DT.101982838  DT.75193611 
    DT.100820027  DT.305855  DT.102843114  DT.40236644  DT.100696384  DT.92443727  DT.95262856  DT.100697818 
    DT.121413863  DT.92443731  DT.92443732  DT.95217362  DT.100676267  DT.100820017  DT.100820034  DT.121413753 

    Selected AceView cDNA sequences (see all 380):

    BE784428 BQ935151 CR603003 BF037690 BI334770 BU543665 BI754485 BU539532 
    BM681562 CA425672 AW732352 CK429713 CF125928 AI380702 BQ922463 BM790519 
    BU153394 AY560600 AY560598 BG488647 AY518542 BM973999 CB270657 BU845588 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM15 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^
    SP1:                                            -     -                                   -                                                                     
    SP2:                                            -     -                                   -                                                                     
    SP3:                                            -     -                                   -                                                                     
    SP4:                                            -     -                                   -                                                                     
    SP5:                                            -     -                                   -                                                                     

    ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                                                -           -               
    SP2:                                                                                -                           
    SP3:                                                                                -           -               
    SP4:                                                                                -                           
    SP5:                                                                                -     -     -               


    ECgene alternative splicing isoforms for ADAM15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAAGGCG
    ADAM15 Expression
    About this image


    ADAM15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Lung (Respiratory System)
     
     Adipose (Muscoskeletal System)
     
     Esophagus (Gastrointestinal Tract)
    ADAM15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.312098

    UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444
    Tissue specificity: Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular
    mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions.
    Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in
    airway smooth muscle and glomerular mesangial cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADAM15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam151 , 5 a disintegrin and metallopeptidase domain 15 (metargidin)1, 5 82.53(n)1
    79.93(a)1
      3 (39.07 cM)5
    114901  NM_001037722.21  NP_001032811.21 
     893385425 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7951991 disintegrin and metalloproteinase domain-containing more 53.29(n)
    44.21(a)
      795199  XM_001335282.4  XP_001335318.4 


    ENSEMBL Gene Tree for ADAM15 (if available)
    TreeFam Gene Tree for ADAM15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM15 gene
    ADAM72  ADAM192  ADAM122  ADAM332  ADAM302  ADAM282  ADAM292  ADAM202  
    ADAM212  ADAM92  ADAM82  
    11 SIMAP similar genes for ADAM15 using alignment to 3 protein entries:     ADA15_HUMAN (see all proteins):
    ADAMDEC1    ADAM9    ADAM12    ADAM19    ADAM23    ADAM28
    ADAM33    ADAM11    ADAM2    ADAM7    ADAM22

    Find genes that share paralogs with ADAM15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM15 (see all 341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928196121,2
    --161527518(+) GTTGTC/TGGTTT 12 -- int10--------
    rs1166697151,2
    F--161527695(+) CCTCCG/ACACAC 12 -- int11Minor allele frequency- A:0.03WA 118
    rs2008526181,2
    F--161527827(+) CTGGGA/GGTTGT 12 -- int11Minor allele frequency- G:0.01EU 447
    rs1449883721,2
    C--161527875(+) ACAGAC/GCAGTC 20 T S mis1 int11Minor allele frequency- G:0.00NA 4550
    rs1843853761,2
    C--161527916(+) TGGACA/GGTGAC 20 S G mis1 int10--------
    rs762684401,2
    C,F--161527926(+) CAGTCA/TTATCC 20 H L mis1 int14Minor allele frequency- T:0.01NA WA 4990
    rs66608841,2
    C,F,A,H--161528095(+) CCTCAT/CTTTAT 12 -- int124Minor allele frequency- C:0.46NS EA NA WA CSA 2234
    rs1116016091,2
    F--161528223(+) TATACT/GTTGCT 12 -- int12Minor allele frequency- G:0.21CSA WA 120
    rs755839321,2
    F--161528240(+) GGGTCA/GGGAGT 12 -- int11Minor allele frequency- G:0.01NA 120
    rs1893138931,2
    C--161528318(+) ATGCAC/TGACCT 12 -- int11Minor allele frequency- T:0.00EU 527

    HapMap Linkage Disequilibrium report for ADAM15 (155023042 - 155035252 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ADAM15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv872455CNV Loss21882294
    nsv524157CNV Loss19592680
    nsv872454CNV Loss21882294
    nsv872456CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605548    OMIM disorders: --


    Find genes that share disorders with ADAM15           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADAM15 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 31 6 11592366 (1), 15818704 (1), 18774960 (1)
    cancer 22.8 15 17937806 (2), 19718658 (2), 19207106 (2), 15618016 (1) (see all 8)
    metastasis 20.7 7 18281484 (2), 19229865 (1), 15756594 (1), 18518760 (1) (see all 6)
    rheumatoid arthritis 14.1 3 11592366 (1), 17905725 (1)
    atherosclerosis 11.4 6 9039960 (2), 17905725 (1), 19253070 (1)
    breast cancer 11.4 12 18434311 (2), 16756724 (2), 19487280 (2), 15384173 (2) (see all 5)
    tumors 10.1 20 15756594 (4), 19229865 (3), 16756724 (2), 18281484 (2) (see all 8)
    adenocarcinoma 2.24 3 16756724 (2), 15756594 (1)
    carcinoma 0.3 3 18296648 (2), 8617717 (1)
    necrosis 0 1 16277668 (1)

    Genetic Association Database (GAD): ADAM15
    Human Genome Epidemiology (HuGE) Navigator: ADAM15 (2 documents)

    Export disorders for ADAM15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM15 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with ADAM15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. (PubMed id 9516430)1, 2, 3, 9 Zhang X.P.... Takada Y. (J. Biol. Chem. 1998)
    2. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PubMed id 11741929)1, 2, 9 Poghosyan Z....Edwards D.R. (J. Biol. Chem. 2002)
    3. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. (PubMed id 9914169)1, 2, 9 Nath D.... Murphy G. (J. Cell Sci. 1999)
    4. ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. (PubMed id 18387333)1, 2, 9 Chen Q.... Ding J. (Int. J. Biochem. Cell Biol. 2008)
    5. Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. (PubMed id 19207106)1, 2, 9 Maretzky T.... Blobel C.P. (Biochem. J. 2009)
    6. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins. (PubMed id 19718658)1, 2, 9 Kleino I.... Saksela K. (J. Cell. Biochem. 2009)
    7. ADAM15 gene structure and differential alternative exon use in human tissues. (PubMed id 17937806)1, 2, 9 Kleino I.... Huovila A.P. (BMC Mol. Biol. 2007)
    8. ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. (PubMed id 15358598)1, 2, 9 Charrier L....Merlin D. (Am. J. Physiol. 2005)
    9. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. (PubMed id 8617717)1, 2, 9 Kraetzschmar J.... Blobel C.P. (J. Biol. Chem. 1996)
    10. The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. (PubMed id 18434311)1, 2, 9 Najy A.J.... Day M.L. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8751 HGNC: 193 AceView: ADAM15andFLJ32785 Ensembl:ENSG00000143537 euGenes: HUgn8751
    ECgene: ADAM15 H-InvDB: ADAM15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADAM15 gene:
    Search GeneIP for patents involving ADAM15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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