ADAM15 Gene
protein-coding GIFtS: 61
GCID: GC01P155023
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|
ADAM metallopeptidase domain 15(Previous name: a disintegrin and metalloproteinase domain 15 (metargidin)...)
| |
Aliases
for ADAM15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADAM Metallopeptidase Domain 151 2 | | Disintegrin And Metalloproteinase Domain-Containing Protein 152 | | MDC151 2 3 5 | | EC 3.4.24.-3 | | A Disintegrin And Metalloproteinase Domain 15 (Metargidin)1 2 | | Metargidin3 | | Metalloprotease RGD Disintegrin Protein2 3 | | ADAM 153 | | Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 152 3 | | EC 3.4.248 | | MDC-152 3 | | |
Export aliases for ADAM15 gene to outside databasesPrevious GC identifers: GC01M148227 GC01P150754 GC01P151799 GC01P152240 GC01P151836 GC01P153290 GC01P126385 |
Summaries
for ADAM15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM15:
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAMfamily members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomainprocessing of cytokines and adhesion molecules. This protein contains multiple functional domains including azinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through itsdisintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interactswith Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein mayfunction in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444Function: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healingprocess. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibitsbeta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on ortowards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration.Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolyticallyprocessed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding throughits disintegrin domain
Gene Wiki entry for ADAM15
|
Genomic Views
for ADAM15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM15 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q21.3ADAM15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P155023: view genomic region
(about GC identifiers)
Start:
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155,023,042 bp from pter |
End:
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155,035,252 bp from pter |
Size:
|
12,211 bases |
Orientation:
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plus strand |
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Proteins
for ADAM15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 15 precursor Size: 863 amino acids; 92959 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurspreferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathwaycompartment prior to the medial Golgi. Interacts with ITAG9-ITGB1 (By similarity). Interacts specifically with Srcfamily protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK,ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC
Subcellular location: Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cellprojection, cilium, flagellum (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golginetwork or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majorityof the protein in the cell is processed (By similarity)
Secondary accessions: B3KQU5 B4DLB5 E9PN65 Q13493 Q53XQ0 Q5SR68 Q5SR69 Q6R267 Q71S61 Q71S62 Q71S63Q71S64 Q71S65 Q71S66 Q71S67 Q71S68 Q71S69 Q96C78Alternative splicing: 12 isoforms: Q13444-1 Q13444-2 Q13444-3 Q13444-4 Q13444-5 Q13444-6 Q13444-7 Q13444-8 Q13444-9 Q13444-10 Q13444-11 Q13444-12 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ADAM15: NX_Q13444
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
Phosphorylation increases association with PTKs1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13444
4 DME Specific Peptides for ADAM15 (Q13444)
ADAM15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (9 alternative transcripts):
NP_001248393.1 NP_001248394.1 NP_001248395.1 NP_003806.3 NP_997074.1 NP_997077.1 NP_997078.1 NP_997079.1 NP_997080.1
ENSEMBL proteins: ENSP00000434227 ENSP00000432347 ENSP00000349436 ENSP00000403843 ENSP00000352226 ENSP00000353892 ENSP00000357397 ENSP00000348227 ENSP00000271836 ENSP00000357398 ENSP00000432927 ENSP00000357395
Human Recombinant Protein Products for ADAM15:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
ADAM15 for ontologies About GeneDecksing
ADAM15 Antibody Products:
Assay Products for ADAM15: |
Protein
Domains /
Families
for ADAM15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM15 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q13444ProtoNet protein and cluster: Q13444 4 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006210 Type I EGF IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444Domain: The cytoplasmic domain is required for SH3GL2- and SNX9-bindingDomain: Disintegrin domain binds to integrin alphaV-beta3Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain |
Function
for ADAM15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ADA15_HUMAN, Q13444Function: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healingprocess. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibitsbeta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on ortowards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration.Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolyticallyprocessed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding throughits disintegrin domainEnzyme regulation: Inhibited by hydroxamate-type metalloproteinase inhibitors such as marimastat. Inhibited bymetalloproteinase inhibitor 2 (TIMP-2) and TIMP-3 at nanomolar concentrations. Not significantly inhibited by TIMP-1at concentrations of up to 100 nM. Not activated by PMA or ionomycin Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ADAM15 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ADAM15:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adam15):
ADAM15 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for ADAM15: Adam15tm1Dgen Adam15tm1Bbl
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM15 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM15 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): ADAM15 (NM_207195) | |  | Sino Biological Human cDNA Clone for ADAM15 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM15 |
|
Pathways & Interactions
for ADAM15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_ECM remodeling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ADAM15
ADAM15 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for ADAM15 (Q134441, 2, 3 ENSP000003494364) via UniProtKB, MINT, STRING, and/or I2D (see all 38)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PACSIN3 | Q9UKS61, 2, 3, ENSP000002988384 | EBI-77818,EBI-77926 MINT-2792521 I2D:
score=4 STRING: ENSP00000298838 | | LCK | P062392, 3, ENSP000003378254 | MINT-7218127 MINT-7218109 MINT-7218034 I2D:
score=6 STRING: ENSP00000337825 | | HCK | P086312, 3, ENSP000003650124 | MINT-2792352 MINT-7218089 MINT-7218157 I2D:
score=4 STRING: ENSP00000365012 | | FYN | P062412, 3, ENSP000003576564 | MINT-7218171 MINT-2792412 I2D:
score=4 STRING: ENSP00000357656 | | SH3PXD2A | Q5TCZ12, 3, ENSP000003482154 | MINT-2792498 MINT-2792970 I2D:
score=4 STRING: ENSP00000348215 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
ADAM15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAM15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADAM15 for compounds About GeneDecksing
 Browse Tocris compounds for ADAM15
3 Novoseek chemical compound relationships for ADAM15 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tripeptide |
46.9 |
6 |
9516430 (1), 9914169 (1), 15618016 (1) |
| fibrinogen |
25.6 |
1 |
16268472 (1) |
| paraffin |
12.3 |
1 |
15756594 (1) |
Search CenterWatch for drugs/clinical trials and news about ADAM15 / ADA15
|
Transcripts
for ADAM15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAM15 gene (9 alternative transcripts): NM_001261464.1 NM_001261465.1 NM_001261466.1 NM_003815.4 NM_207191.2 NM_207194.2 NM_207195.2 NM_207196.2 NM_207197.2 Unigene Cluster for ADAM15: ADAM metallopeptidase domain 15 Hs.312098 [show with all ESTs]Unigene Representative Sequence: NR_04857818/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33): ENST00000473905 ENST00000533732 ENST00000480331 ENST00000527418(uc001fgq.1 uc001fgt.1 uc001fgs.1 uc010pev.1 uc001fgr.1 uc001fgu.1 uc001fgv.1 uc001fgw.1 uc001fgx.1)
ENST00000529473(uc001fha.1) ENST00000526491(uc001fgz.1 uc001fgy.1)
ENST00000356955 ENST00000449910 ENST00000359280 ENST00000360674(uc009wpc.1)
ENST00000368412 ENST00000355956 ENST00000531703 ENST00000477533 ENST00000271836
ENST00000461564(uc010peu.1) ENST00000485346 ENST00000368413
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM15 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAM15 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): ADAM15 (NM_207195) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM15 |
Additional cDNA sequence: AK000667.1 AK075498.1 AK295614.1 AK296925.1 AK297468.1 AK308172.1 AY518542.1 AY560593.1 AY560594.1 AY560595.1 AY560596.1 AY560597.1 AY560598.1 AY560599.1 AY560600.1 AY560601.1 AY576417.1 BC014566.2 BT009764.1 NR_048577.1 NR_048578.1 NR_048579.1 U41767.1 U46005.1 24/29 DOTS entries (see all 29): DT.92048682 DT.102843113 DT.95179450 DT.102843115 DT.100766007 DT.99979216 DT.101982838 DT.75193611 DT.100820027 DT.305855 DT.102843114 DT.40236644 DT.100696384 DT.92443727 DT.95262856 DT.100697818 DT.121413863 DT.92443731 DT.92443732 DT.95217362 DT.100676267 DT.100820017 DT.100820034 DT.121413753 24/380 AceView cDNA sequences (see all 380): BF037690 CK300163 BM681562 AL120796 AY560595 CA748879 CK903493 BE784428 AY560601 AI380702 BM824762 BU845588 CB853121 BQ935151 AY560599 CA487716 BQ922463 CD672282 CR603003 BX360706 BM683404 BM793873 BU153394 AY518542
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM15 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for ADAM15
|
Expression
for ADAM15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAM15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGAAGGCG
About this image
See ADAM15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAM15
SOURCE GeneReport for Unigene cluster: Hs.312098
UniProtKB/Swiss-Prot: ADA15_HUMAN, Q13444Tissue specificity: Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangialcells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressedin cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerularmesangial cells
SABiosciences Custom PCR Arrays for ADAM15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAM15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAM15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM15 |
Orthologs
for ADAM15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ADAM15 gene from 1/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7951991 |
disintegrin and metalloproteinase domain-containing more |
53.92(n)
45.85(a) |
|
795199 XM_001335282.3 XP_001335318.3 |
ENSEMBL Gene Tree for ADAM15 (if available)
TreeFam Gene Tree for ADAM15 (if available) |
Paralogs
for ADAM15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAM15 gene
- ADAM72 ADAM192 ADAM122 ADAM232 ADAM332 ADAM112 ADAM302 ADAM222
- ADAM282 ADAM292 ADAM202 ADAM92 ADAM212 ADAM82
12 SIMAP similar genes for ADAM15 using alignment to 2 protein entries: ADA15_HUMAN (see all proteins):ADAMDEC1 ADAM9 ADAM23 ADAM12 ADAM19 ADAM2
ADAM28 ADAM11 ADAM22 ADAM7 ADAM20 ADAM33
ADAM15 for paralogs About GeneDecksing
|
Genomic Variants
for ADAM15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAM15 (155023042 - 155035252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAM15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAM15 |
|
Disorders
/ Diseases
for ADAM15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAM15 for disorders About GeneDecksing
OMIM gene information: 605548
OMIM disorders: --
20/24  diseases for ADAM15 (see all 24): About MalaCardscongenital heart defect inflammatory bowel disease rheumatoid arthritis dilated cardiomyopathy
squamous cell carcinoma prostate cancer prostate cancer, progression of down syndrome
osteoarthritis epididymitis cardiomyopathy arthritis
breast cancer alzheimer's disease prostatitis ovarian cancer
gastric cancer lung carcinoma carcinoma breast carcinoma
10/11 Novoseek disease relationships for ADAM15 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| osteoarthritis |
31 |
6 |
11592366 (1), 15818704 (1), 18774960 (1) |
| cancer |
22.8 |
15 |
17937806 (2), 19718658 (2), 19207106 (2), 15618016 (1) (see all 8) |
| metastasis |
20.7 |
7 |
18281484 (2), 19229865 (1), 15756594 (1), 18518760 (1) (see all 6) |
| rheumatoid arthritis |
14.1 |
3 |
11592366 (1), 17905725 (1) |
| atherosclerosis |
11.4 |
6 |
9039960 (2), 17905725 (1), 19253070 (1) |
| breast cancer |
11.4 |
12 |
18434311 (2), 16756724 (2), 19487280 (2), 15384173 (2) (see all 5) |
| tumors |
10.1 |
20 |
15756594 (4), 19229865 (3), 16756724 (2), 18281484 (2) (see all 8) |
| adenocarcinoma |
2.24 |
3 |
16756724 (2), 15756594 (1) |
| carcinoma |
0.3 |
3 |
18296648 (2), 8617717 (1) |
| necrosis |
0 |
1 |
16277668 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADAM15 (2 documents)
Export disorders for ADAM15 gene to outside databases
|
Publications
for ADAM15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAM15 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with ADAM15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. (PubMed id 9516430)1, 2, 3, 9 Zhang X.P.... Takada Y. (1998)
- Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PubMed id 11741929)1, 2, 9 Poghosyan Z....Edwards D.R. (2002)
- Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. (PubMed id 9914169)1, 2, 9 Nath D....Murphy G. (1999)
- ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. (PubMed id 18387333)1, 2, 9 Chen Q....Ding J. (2008)
- Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. (PubMed id 19207106)1, 2, 9 Maretzky T....Blobel C.P. (2009)
- Alternative splicing of ADAM15 regulates its interact ions with cellular SH3 proteins. (PubMed id 19718658)1, 2, 9 Kleino I....Saksela K. (2009)
- ADAM15 gene structure and differential alternative exon use in human tissues. (PubMed id 17937806)1, 2, 9 Kleino I....Huovila A.P. (2007)
- ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. (PubMed id 15358598)1, 2, 9 Charrier L....Merlin D. (2005)
- Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. (PubMed id 8617717)1, 2, 9 Kraetzschmar J.... Blobel C.P. (1996)
- The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. (PubMed id 18434311)1, 2, 9 Najy A.J....Day M.L. (2008)
|
External Searches for ADAM15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAM15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAM15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAM15 gene:
Search GeneIP for patents involving ADAM15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM15 |
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