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Aliases for ADAM15 Gene

Aliases for ADAM15 Gene

  • ADAM Metallopeptidase Domain 15 2 3
  • MDC15 3 4 6
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 15 3 4
  • A Disintegrin And Metalloproteinase Domain 15 (Metargidin) 2 3
  • Metalloprotease RGD Disintegrin Protein 3 4
  • Metargidin 2 4
  • MDC-15 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 15 3
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • ADAM 15 4

External Ids for ADAM15 Gene

Previous GeneCards Identifiers for ADAM15 Gene

  • GC01M148227
  • GC01P150754
  • GC01P151799
  • GC01P152240
  • GC01P151836
  • GC01P153290
  • GC01P126385

Summaries for ADAM15 Gene

Entrez Gene Summary for ADAM15 Gene

  • The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM15 Gene

ADAM15 (ADAM Metallopeptidase Domain 15) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Notch Signaling Pathway (sino). GO annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM15 Gene

  • Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Gene Wiki entry for ADAM15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM15 Gene

Genomics for ADAM15 Gene

Regulatory Elements for ADAM15 Gene

Genomic Location for ADAM15 Gene

Start:
155,050,566 bp from pter
End:
155,062,776 bp from pter
Size:
12,211 bases
Orientation:
Plus strand

Genomic View for ADAM15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM15 Gene

Proteins for ADAM15 Gene

  • Protein details for ADAM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13444-ADA15_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 15
    Protein Accession:
    Q13444
    Secondary Accessions:
    • B3KQU5
    • B4DLB5
    • B4DMH8
    • E9PN65
    • Q13493
    • Q53XQ0
    • Q5SR68
    • Q5SR69
    • Q6R267
    • Q71S61
    • Q71S62
    • Q71S63
    • Q71S64
    • Q71S65
    • Q71S66
    • Q71S67
    • Q71S68
    • Q71S69
    • Q96C78
    • U3KQL5

    Protein attributes for ADAM15 Gene

    Size:
    863 amino acids
    Molecular mass:
    92959 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1 (By similarity). Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC.

    Alternative splice isoforms for ADAM15 Gene

neXtProt entry for ADAM15 Gene

Proteomics data for ADAM15 Gene at MOPED

Selected DME Specific Peptides for ADAM15 Gene

Post-translational modifications for ADAM15 Gene

Domains for ADAM15 Gene

Gene Families for ADAM15 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13444

UniProtKB/Swiss-Prot:

ADA15_HUMAN :
  • Q13444
Domain:
  • The cytoplasmic domain is required for SH3GL2- and SNX9-binding
  • Disintegrin domain binds to integrin alphaV-beta3
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM15: view

Function for ADAM15 Gene

Molecular function for ADAM15 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by hydroxamate-type metalloproteinase inhibitors such as marimastat. Inhibited by metalloproteinase inhibitor 2 (TIMP-2) and TIMP-3 at nanomolar concentrations. Not significantly inhibited by TIMP-1 at concentrations of up to 100 nM. Not activated by PMA or ionomycin.
UniProtKB/Swiss-Prot Function: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Enzyme Numbers (IUBMB) for ADAM15 Gene

Gene Ontology (GO) - Molecular Function for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding IMP 22505472
GO:0005515 protein binding IPI 10531379
GO:0008237 metallopeptidase activity IDA 12777399
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM15: view

Phenotypes for ADAM15 Gene

genes like me logo Genes that share phenotypes with ADAM15: view

Animal Models for ADAM15 Gene

MGI Knock Outs for ADAM15:

miRNA for ADAM15 Gene

miRTarBase miRNAs that target ADAM15

No data available for Transcription Factor Targeting and HOMER Transcription for ADAM15 Gene

Localization for ADAM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM15 Gene

Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM15 Gene COMPARTMENTS Subcellular localization image for ADAM15 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0009986 cell surface IDA 22505472
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM15: view

Pathways for ADAM15 Gene

genes like me logo Genes that share pathways with ADAM15: view

Pathways by source for ADAM15 Gene

1 Sino Biological pathway for ADAM15 Gene

Gene Ontology (GO) - Biological Process for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001953 negative regulation of cell-matrix adhesion IMP 22505472
GO:0006508 proteolysis IEA --
GO:0006915 NOT apoptotic process IDA 22505472
GO:0007160 cell-matrix adhesion TAS 9516430
genes like me logo Genes that share ontologies with ADAM15: view

Compounds for ADAM15 Gene

(3) Novoseek inferred chemical compound relationships for ADAM15 Gene

Compound -log(P) Hits PubMed IDs
tripeptide 46.9 3
fibrinogen 25.6 1
paraffin 12.3 1
genes like me logo Genes that share compounds with ADAM15: view

Transcripts for ADAM15 Gene

Unigene Clusters for ADAM15 Gene

ADAM metallopeptidase domain 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - -
SP15:
SP16: - - - - - - - - - - - - - - - - - -
SP17: - -
SP18: - -
SP19: - - -
SP20:
SP21:

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - - -
SP12:
SP13:
SP14:
SP15: - -
SP16: - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ADAM15 Gene

GeneLoc Exon Structure for
ADAM15
ECgene alternative splicing isoforms for
ADAM15

Expression for ADAM15 Gene

mRNA expression in normal human tissues for ADAM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAM15 Gene

SOURCE GeneReport for Unigene cluster for ADAM15 Gene Hs.312098

mRNA Expression by UniProt/SwissProt for ADAM15 Gene

Q13444-ADA15_HUMAN
Tissue specificity: Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
genes like me logo Genes that share expressions with ADAM15: view

No data available for mRNA differential expression in normal tissues for ADAM15 Gene

Orthologs for ADAM15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM15 35
  • 99.23 (n)
  • 98.84 (a)
ADAM15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM15 35
  • 84.76 (n)
  • 82.68 (a)
ADAM15 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM15 35
  • 83.45 (n)
  • 81.61 (a)
ADAM15 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam15 35
  • 82.53 (n)
  • 79.93 (a)
Adam15 16
Adam15 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM15 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam15 35
  • 82.44 (n)
  • 80.6 (a)
zebrafish
(Danio rerio)
Actinopterygii adam15 36
  • 37 (a)
OneToOne
LOC795199 35
  • 53.29 (n)
  • 44.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ADAM15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM15 Gene

ENSEMBL:
Gene Tree for ADAM15 (if available)
TreeFam:
Gene Tree for ADAM15 (if available)

Paralogs for ADAM15 Gene

Selected SIMAP similar genes for ADAM15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAM15: view

Variants for ADAM15 Gene

Sequence variations from dbSNP and Humsavar for ADAM15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_054339 -
VAR_060315 -
VAR_060316 -
VAR_068970 -

Structural Variations from Database of Genomic Variants (DGV) for ADAM15 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872454 CNV Loss 21882294
nsv872455 CNV Loss 21882294
nsv524157 CNV Loss 19592680
nsv872456 CNV Loss 21882294

Relevant External Links for ADAM15 Gene

HapMap Linkage Disequilibrium report
ADAM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM15 Gene

Disorders for ADAM15 Gene

(11) Novoseek inferred disease relationships for ADAM15 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 31 3
cancer 22.8 11
metastasis 20.7 7
rheumatoid arthritis 14.1 2
atherosclerosis 11.4 4

Relevant External Links for ADAM15

Genetic Association Database (GAD)
ADAM15
Human Genome Epidemiology (HuGE) Navigator
ADAM15
genes like me logo Genes that share disorders with ADAM15: view

No data available for UniProtKB/Swiss-Prot for ADAM15 Gene

Publications for ADAM15 Gene

  1. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. (PMID: 9516430) Zhang X.P. … Takada Y. (J. Biol. Chem. 1998) 2 3 4 23
  2. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. (PMID: 8617717) Kraetzschmar J. … Blobel C.P. (J. Biol. Chem. 1996) 3 4 23
  3. Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. (PMID: 9039960) Herren B. … Ross R. (FASEB J. 1997) 3 4 23
  4. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. (PMID: 9914169) Nath D. … Murphy G. (J. Cell Sci. 1999) 3 4 23
  5. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PMID: 11741929) Poghosyan Z. … Edwards D.R. (J. Biol. Chem. 2002) 3 4 23

Products for ADAM15 Gene

Sources for ADAM15 Gene

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