Aliases for ADAM12 Gene
External Ids for ADAM12 Gene
Previous GeneCards Identifiers for ADAM12 Gene
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
GeneCards Summary for ADAM12 Gene
ADAM12 (ADAM Metallopeptidase Domain 12) is a Protein Coding gene. Diseases associated with ADAM12 include Cone-Rod Dystrophy 9 and Ectopic Pregnancy. Among its related pathways are Syndecan-4-mediated signaling events and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM19.
UniProtKB/Swiss-Prot for ADAM12 Gene
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).