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ADAM12 Gene

protein-coding GIFtS: 66

GC10M127693

ADAM metallopeptidase domain 12
(Previous name: a disintegrin and metalloproteinase domain 12 (meltrin alpha) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.- ^³
MCMP ^²
MCMPMltna ^¹, ²
MLTN ^¹, ², ³, ⁵
MLTNA ^²
Meltrin-alpha ^³
OTTHUMP00000020727 ^²
OTTHUMP00000046766 ^²

Descriptions
ADAM 12 ^³
ADAM metallopeptidase domain 12 ^²
a disintegrin and metalloproteinase domain 12 (meltrin alpha) ^¹, ²
meltrin alpha ^²

External Ids
HGNC: 190¹
Entrez Gene: 8038²
UniProtKB: O43184³
Ensembl: ENSG00000148848⁷

Search outside databases for aliases for ADAM12 gene

Previous GC identifers: GC10M126678 GC10M126907 GC10M127744 GC10M127278

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM12:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members

of this family are membrane-anchored proteins structurally related to snake venom disintegrins,

and have been implicated in a variety of biological processes involving cell-cell and cell-matrix

interactions, including fertilization, muscle development, and neurogenesis. This gene has two

alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The

shorter form is found to stimulate myogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA12_HUMAN, O43184

Function: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also

involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear

precursors (By similarity)

Gene Wiki entry for ADAM12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM12 gene

Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26

ADAM12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M127693: (about GC identifiers)

Start:	127,693,415 bp from pter
End:	128,067,055 bp from pter
Size:	373,641 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_035040.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA12_HUMAN, O43184 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 12 precursor

Size: 909 amino acids; 99542 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Isoform 3: Secreted (Potential)

Subcellular location: Isoform 4: Secreted (Potential)

Secondary accessions: O60470 Q5JRP0 Q5JRP1 Q6P9E3 Q6UWB0

Alternative splicing: 4 isoforms: O43184-1 O43184-2 O43184-3 O43184-4

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003465.3 NP_067673.2

ENSEMBL proteins:

ENSP00000357668 ENSP00000357672 ENSP00000357665

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAM12
	Enzo Life Sciences proteins for ADAM12
	Recombinant Proteins from Abcam (ADAM12)
	Human Recombinant Proteins from Abnova (ADAM12)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	7566181
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ADAM12:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM12
	Sigma-Aldrich Antibodies for ADAM12
	R&D Systems Antibodies for ADAM12
	Antibodies from Abcam (ADAM12), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM12)
	Novus Biologicals Antibodies for ADAM12

Assays for ADAM12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O43184

ProtoNet protein and cluster: O43184

3 Blocks protein families:

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB006586 ADAM

UniProtKB/Swiss-Prot: ADA12_HUMAN, O43184

Domain: The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling

events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of

this domain to syndecans does not allow the integrin-mediated cell spreading

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021641

Applied Biosystems Silencer® siRNAs for ADAM12

Sigma-Aldrich siRNA and siRNA Panels for ADAM12

Sigma-Aldrich shRNA Panels and shRNA for ADAM12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADAM12
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003474
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003474
untagged cDNA clones in CMV expression vector (see all 2): NM_003474

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003474

UniProtKB/Swiss-Prot: ADA12_HUMAN, O43184

Function: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also

involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear

precursors (By similarity)

Enzyme Number (IUBMB): EC 3.4.24.-

Genatlas biochemistry entry for ADAM12:

a disintegrin and metalloprotease (active) domain 12,membrane anchored cell surface protein,with

two alternatively spliced isoforms L and S,expressed in term placenta,in adult

skeletal,cardiac,smooth muscle,bone,required for myotube formation and in osteoblast

differentiation,involved in tumor cell adhesion

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adam12):

	adipose tissue	lethality-postnatal	lethality-prenatal/perinatal	muscle
vision/eye

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADAM12 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks ADAM12 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADAM12

5/25 Interacting proteins for ADAM12 (ENSP00000357672³ O43184²) via UniProtKB, MINT, and/or STRING (see all 25 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3D19	Q5HYK7²	STRING (score=.836) MINT-56613 MINT-56611 MINT-56614 MINT-56612
EGF	ENSP00000265171³	STRING (score=.979)
PACSIN3	ENSP00000298838³	STRING (score=.966)
SRC	ENSP00000362659³	STRING (score=.965)
EGFR	ENSP00000275493³	STRING (score=.954)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007520	myoblast fusion	TAS	7566181

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM12

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADAM12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021641

Sigma-Aldrich siRNA and siRNA Panels for ADAM12

Sigma-Aldrich shRNA Panels and shRNA for ADAM12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003474 NM_021641

REFSEQ mRNAs for ADAM12 gene (2 alternative transcripts):

NM_003474.4 NM_021641.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003474 NM_021641

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003474
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003474
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003474

Additional cDNA sequence:

AF023476.2 AF023477.2 AK022196.1 AK127856.1 AK291629.1 AY358878.1 BC060804.1 CR596848.1

CR600916.1 CR611528.1 CR616307.1

24/56 DOTS entries (see all 56 ):

DT.95357317 DT.100761106 DT.100797831 DT.121223074 DT.95357338 DT.92459374 DT.99980124 DT.86853140

DT.95357321 DT.91701420 DT.95320779 DT.92459370 DT.95357332 DT.100797829 DT.95090158 DT.91682841

DT.97811007 DT.121223228 DT.91694111 DT.121223209 DT.121223692 DT.91685882 DT.121223583 DT.92459375

24/518 AceView cDNA sequences (see all 518 ):

R23753 AI095755 AU140312 BG620679 AU139359 BQ014718 BF988246 AW069127

AI247515 BI056244 AU137315 BQ020227 AA368712 BU752256 AI371787 AI753141

AU134592 AA909684 CR600916 BE208298 H12677 AI139427 AU139012 AI188560

highest scoring ESTs for ADAM12:

AF023476 AF023477 AA852875 AL545388 AU135040 AU135794 AU135901 AU136109 AU136284 AU136399

Unigene Cluster for ADAM12:

ADAM metallopeptidase domain 12

Hs.594537 [show with all ESTs]

Unigene Representative Sequence: NM_003474

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM12

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24
SP1:																																							-
SP2:									-
SP3:									-
SP4:

About this scheme

ECgene alternative splicing isoforms for ADAM12

3 Ensembl transcripts including schematic representations:

ENST00000368679 ENST00000368683 ENST00000368676

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADAM12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM12

¹ / ² / ³

10 probe-sets matching ADAM12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38769_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF023477	1.00	0.90	0.95	1
38770_at²^{, 3}	U95-A	1	1.00	1.00	0.21	0.37	AF023476	1.00	0.90	0.95	1
202952_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003474	0.60	1.00	0.82	1
213790_at²^{, 3}	U133-A	1	1.00	1.00	--	--	W46291	0.60	1.00	0.82	1
204943_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021641	0.60	1.00	0.82	1
215613_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AU145357	0.40	1.00	0.76	1
202952_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213790_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204943_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215613_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAGCCCTTC

SOURCE GeneReport for Unigene cluster: Hs.594537
Expression variation in blood from EXPOLDB for ADAM12
UniProtKB/Swiss-Prot: ADA12_HUMAN, O43184
Tissue specificity: Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle.
Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed
in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM12 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADAM12¹	--	ADAM metallopeptidase domain 12	99.17(n) 98.64(a)	450818 XM_508106.2 XP_508106.2
cow (Bos taurus)	ADAM12¹	--	ADAM metallopeptidase domain 12	84.7(n) 82.96(a)	407229 NM_001001156.1 NP_001001156.1
rat (Rattus norvegicus)	Adam12¹	--	ADAM metallopeptidase domain 12	82.98(n) 82.57(a)	679837 XM_001054670.1 XP_001054670.1
mouse (Mus musculus)	Adam12^{1, 5}	7⁵	a disintegrin and metallopeptidase domain 12 (meltrin more^{1, 5}	83.3(n)¹ 81.89(a)¹	11489¹ NM_007400.2¹ NP_031426.2¹ AK051780⁵ AK165814⁵ (see all 9)
chicken (Gallus gallus)	ADAM12¹	--	ADAM metallopeptidase domain 12 (meltrin alpha)	72.45(n) 72.82(a)	425843 XM_423549.2 XP_423549.2

About this table Species with no ortholog for ADAM12

ENSEMBL Gene Tree for ADAM12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM12 gene

ADAM19² ADAM15² ADAM33²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2724 NCBI SNPs in ADAM12 are shown (see all 2724 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1130)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1044169^1,2	A,C,F,H,O	127693100(-)	`TTACAC/TTTCAC`	1	--	ut3¹		8	MN NA EU EA WA	744
	rs1290149^1,2	A,C,F,H,O	127719744(+)	`GCTTAG/ATGTCT`	2	--	ng5¹ int¹		17	MN EU EA WA NA	1658
	rs4732^1,2	A,C,F,H,O	127720134(+)	`TTTCAA/TTGCCA`	2	--	int¹ ut3¹		17	MN EA NA EU WA	3044
	rs6693^1,2	A,C,F,H	127720350(-)	`GAGCCC/TCCACA`	2	--	ut3¹ int¹ ese³		12	MN NA EU EA WA	1130
	rs10794057^1,2	A,C,F,H	127719724(+)	`ACTTAT/CGCCAT`	2	--	int¹ ng5¹		8	EU EA WA	838
	rs7916918^1,2	A,C,F,H	127695357(+)	`TTGGCC/TCTGGC`	1	--	ut3¹ ese³		4	EU EA WA	416
	rs10751538^1,2	A,C,F,H	127695270(+)	`CCCAGC/GTGTCC`	1	--	ut3¹ ese³		4	EU EA WA	410
	rs7913591^1,2	A,C,F,H	127695394(+)	`CTGAGG/ATTCTA`	1	--	ut3¹ ese³		7	NA EU EA WA	558
	rs3740199^1,2	A,C,F,H	128009015(+)	`ACTCCC/GAACAG`	2	G/R	mis¹		21	EA NA EU WA	1904
	rs10842^1,2	A,C,F	127720294(-)	`AGTGAC/TACCTC`	2	--	int¹ ut3¹ ese³		4	MN NA	326

About this table

HapMap Linkage Disequilibrium images for ADAM12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602714

10/13 Novoseek disease relationships for ADAM12 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	39.78	13	19285649 (4), 14691998 (4), 18785180 (3), 17701664 (1)
giant cell tumors	38.02	5	11769731 (4), 16251041 (1)
preeclampsia	29.06	10	15994630 (5), 18978109 (4)
trisomy	28.17	11	17701664 (5), 19285649 (2)
rhabdomyosarcoma	22.24	2	15364951 (1), 15574885 (1)
tumors	20.50	28	15930294 (5), 17189408 (3), 11769731 (3), 16061220 (2) (see all 14)
chromosomal aberrations	11.69	6	17278174 (2), 19285649 (2), 17701664 (1)
cancer	1.17	8	18342566 (1), 16213489 (1), 17189408 (1), 16495931 (1) (see all 8)
inflammation	0.00	1	17088949 (1)
carcinoma	0.00	2	10329602 (1), 12717386 (1)

About this table

Human Genome Epidemiology Navigator: ADAM12 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/115 PubMed articles for ADAM12 gene (see all 115 ):

A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. (PubMed id 9417060)^{1, 2, 3, 4} Gilpin B.J....Wewer U.M. (1998)
Cellular roles of ADAM12 in health and disease. (PubMed id 18342566)^{1, 2, 3} Kveiborg M....Wewer U.M. (2008)
Human ADAM 12 (meltrin alpha) is an active metalloprotease. (PubMed id 9642263)^{1, 3, 4} Loechel F.... Wewer U.M. (1998)
The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)^{1, 3, 4} Abram C.L....Courtneidge S.A. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading. (PubMed id 10831617)^{3, 4} Iba K.... Wewer U.M. (2000)
ADAM12: a potential target for the treatment of chronic wounds. (PubMed id 18604515)^{1, 3} Harsha A....Tomic-Canic M. (2008)
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy. (PubMed id 17701664)^{1, 3} Spencer K. and Cowans N.J. (2007)
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation. (PubMed id 15574885)^{1, 3} Lafuste P....Authier F.J. (2005)
Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. (PubMed id 15364951)^{1, 3} Sundberg C....Wewer U.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8038	HGNC: 190	AceView: ADAM12	Ensembl:ENSG00000148848	euGenes: HUgn8038
ECgene: ADAM12	H-InvDB: ADAM12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADAM12	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ADAM12
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADAM12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM12		Antibodies for ADAM12
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADAM12)
	Antibodies (ADAM12)
	Chimera RNAi (ADAM12)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Drugs/Proteins for ADAM12
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADAM12

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADAM12 Gene at Home site.
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ADAM12 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADAM12

Summaries
for ADAM12

Genomic Location
for ADAM12

Proteins
for ADAM12

Protein Domains/
Families
for ADAM12

Gene Function
for ADAM12

Pathways & Interactions
for ADAM12

Drugs & Compounds
for ADAM12

Transcripts
for ADAM12

Expression
for ADAM12

Orthologs
for ADAM12

Paralogs
for ADAM12

SNPs/Variants
for ADAM12

Disorders & Mutations
for ADAM12

Medical News
for ADAM12

Publications
for ADAM12

Search for ADAM12

Genome Databases showing ADAM12

Other Databases showing ADAM12

Specialized Databases showing ADAM12

Licensable Technologies
for ADAM12

Services
for ADAM12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM12 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADAM12

Summariesfor ADAM12

Genomic Locationfor ADAM12

Proteinsfor ADAM12

Protein Domains/Familiesfor ADAM12

Gene Functionfor ADAM12

Pathways & Interactionsfor ADAM12

Drugs & Compoundsfor ADAM12

Transcriptsfor ADAM12

Expression for ADAM12

Orthologsfor ADAM12

Paralogsfor ADAM12

SNPs/Variantsfor ADAM12

Disorders & Mutationsfor ADAM12

Medical Newsfor ADAM12

Publicationsfor ADAM12

Search for ADAM12

Genome Databases showing ADAM12

Other Databases showing ADAM12

Specialized Databases showing ADAM12

Licensable Technologiesfor ADAM12

Servicesfor ADAM12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM12

Summaries
for ADAM12

Genomic Location
for ADAM12

Proteins
for ADAM12

Protein Domains/
Families
for ADAM12

Gene Function
for ADAM12

Pathways & Interactions
for ADAM12

Drugs & Compounds
for ADAM12

Transcripts
for ADAM12

Expression
for ADAM12

Orthologs
for ADAM12

Paralogs
for ADAM12

SNPs/Variants
for ADAM12

Disorders & Mutations
for ADAM12

Medical News
for ADAM12

Publications
for ADAM12

Licensable Technologies
for ADAM12

Services
for ADAM12